Gene Symbol: SEMA6A
Description: semaphorin 6A
Alias: HT018, SEMA, SEMA6A1, SEMAQ, VIA, semaphorin-6A, SEMA6A-1, sema VIa, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A, semaphorin 6A-1, semaphorin VIA
Species: human
Products:     SEMA6A

Top Publications

  1. Ramasamy A, Curjuric I, Coin L, Kumar A, McArdle W, Imboden M, et al. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol. 2011;128:996-1005 pubmed publisher
    ..This relatively large meta-analysis of GWASs identified few loci associated with AR and grass sensitization. No birth order interaction was identified in the current analyses. ..
  2. Schatz F, Guzeloglu Kayisli O, Arlier S, Kayisli U, Lockwood C. The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding. Hum Reprod Update. 2016;22:497-515 pubmed publisher
    ..Moreover, aberrant TF-derived thrombin signaling also contributes to the pathogenesis of endometriosis via induction of angiogenesis, inflammation and cell survival...
  3. Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev. 2001;81:629-83 pubmed
    ..The OT receptor is a typical class I G protein-coupled receptor that is primarily coupled via G(q) proteins to phospholipase C-beta...
  4. Al Obaidi M, Desa M. Mechanisms of Blood Brain Barrier Disruption by Different Types of Bacteria, and Bacterial-Host Interactions Facilitate the Bacterial Pathogen Invading the Brain. Cell Mol Neurobiol. 2018;: pubmed publisher
    ..Brain microvascular endothelial cells (BMECs) permeability and BBB disruption are induced via interendothelial junction proteins reduction as well as up-regulation of IL-1?, IL-1?, IL-6, TNF-?, MCP-1, ..
  5. Geerdes Fenge H. [Travel-associated pneumonias]. Pneumologie. 2014;68:685-95 pubmed publisher
    ..Transmission of zoonotic diseases occurs mainly via contact with infected animals or their excretions, human-to-human transmission is generally rare: MERS-CoA (..
  6. Tutar Y. miRNA and cancer; computational and experimental approaches. Curr Pharm Biotechnol. 2014;15:429 pubmed
    ..Exosomal shuttle small RNAs mediate cell to cell communication and regulate cancer metastasis. The regulation via heterotypic signals in the microenvironment was explained by Dr. Liang and Dr. Yu groups...
  7. Roy S, Esmaeilniakooshkghazi A, Patnaik S, Wang Y, George S, Ahrorov A, et al. Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation. Gastroenterology. 2018;154:1405-1420.e2 pubmed publisher
    ..along with enteroids and human IEC lines, we found that induction of cell stress alters the cytoskeleton in IECs via changes in the actin-binding proteins VIL1 and GSN...
  8. Kim M, Ku S, Kim S, Lee H, Jin H, Kang S, et al. Safety Evaluations of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI. Int J Mol Sci. 2018;19: pubmed publisher
    ..WHO) has suggested that lactic acid bacteria be characterized and proven safe for consumers’ health via multiple experiments (e.g...
  9. Cianciotto N, White R. Expanding Role of Type II Secretion in Bacterial Pathogenesis and Beyond. Infect Immun. 2017;85: pubmed publisher
    ..This minireview provides an update on the types of bacteria that have T2S, the kinds of proteins that are secreted via T2S, and how T2S substrates promote infection.

More Information

Publications156 found, 100 shown here

  1. Tebay L, Robertson H, Durant S, Vitale S, Penning T, Dinkova Kostova A, et al. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic Biol Med. 2015;88:108-146 pubmed publisher
    ..Thus Nrf2 activity is tightly controlled via CRLKeap1 and SCFβ-TrCP by oxidative stress and energy-based signals, allowing it to mediate adaptive responses ..
  2. Dong L, Han X, Tao X, Xu L, Xu Y, Fang L, et al. Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. Foods. 2018;7: pubmed publisher
  3. Valero T. Mitochondrial biogenesis: pharmacological approaches. Curr Pharm Des. 2014;20:5507-9 pubmed
    ..2]. Mitochondrial biogenesis is therefore defined as the process via which cells increase their individual mitochondrial mass [3]...
  4. He X, Wang X, Fang J, Chang Y, Ning N, Guo H, et al. The genus Achyranthes: A review on traditional uses, phytochemistry, and pharmacological activities. J Ethnopharmacol. 2017;203:260-278 pubmed publisher
    ..The relevant information on Achyranthes species was gathered from worldwide accepted scientific databases via electronic search (Google Scholar, Web of Science, ScienceDirect, ACS Publications, PubMed, Wiley Online Library, ..
  5. Gao P, Yang B, Yu H, Meng R, Si J. Carvedilol alleviates the biliary cirrhosis through inhibiting the endoplasmic reticulum stress. Eur Rev Med Pharmacol Sci. 2017;21:5813-5820 pubmed publisher
    ..iNOS) and cyclooxygenase-2 (COX-2), transforming growth factor ?-1 (TGF-?1), ?-SMA and collagen-1 were detected via reverse transcription-polymerase chain reaction (RT-PCR)...
  6. Pall M, Levine S. Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors. Sheng Li Xue Bao. 2015;67:1-18 pubmed
    ..leading to increased detoxification and excretion of both organic xenobiotics and toxic metals; its action via over two dozen genes increases highly coordinated antioxidant activities; it produces major anti-inflammatory ..
  7. Yeşilbaş O, Sevketoglu E, Kihtir H, Talip Petmezci M, Bato E, Balkaya S, et al. [A case of bronchiolitis obliterans secondary to human metapneumovirus bronchiolitis]. Mikrobiyol Bul. 2016;50:606-612 pubmed
    ..On the 76th day of admission, she was discharged with respiratory support with home ventilation via a tracheostomy cannula and medical treatments of oral metilprednisolone, nebulized salbutamol and budesonide...
  8. Valko M, Jomova K, Rhodes C, Kuča K, Musílek K. Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Arch Toxicol. 2016;90:1-37 pubmed publisher
    ..The breakdown of metal ion homeostasis can lead to an uncontrolled formation of reactive oxygen species, ROS (via the Fenton reaction, which produces hydroxyl radicals), and reactive nitrogen species, RNS, which may cause ..
  9. Li S, Feng L, Jiang W, Liu Y, Jiang J, Wu P, et al. Deficiency of dietary niacin impaired gill immunity and antioxidant capacity, and changes its tight junction proteins via regulating NF-?B, TOR, Nrf2 and MLCK signaling pathways in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;55:212-22 pubmed publisher
    ..05). In conclusion, niacin deficiency decreased gill immunity, impaired gill antioxidant system, as well as regulated mRNA expression of gill tight junction proteins and related signaling molecules of fish. ..
  10. Groom K, David A. The role of aspirin, heparin, and other interventions in the prevention and treatment of fetal growth restriction. Am J Obstet Gynecol. 2018;218:S829-S840 pubmed publisher
    ..advanced being maternal vascular endothelial growth factor gene therapy, which is being translated into the clinic via the doEs Vascular endothelial growth factor gene therapy safEly impRove outcome in seveRe Early-onset fetal growth ..
  11. Simon Y, Kessler S, Gemperlein K, Bohle R, Müller R, Haybaeck J, et al. Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis. World J Gastroenterol. 2014;20:17839-50 pubmed publisher
    ..reductase or HMGCR) were not significantly upregulated, potentially due to increased cholesterol biosynthesis via elevated sterol regulatory element binding transcription factor 2 (SREBF2) gene expression and increased iron ..
  12. Zhong W, Qian K, Xiong J, Ma K, Wang A, Zou Y. Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-?B related signaling. Biomed Pharmacother. 2016;83:302-313 pubmed publisher
    ..Strategies to inhibit inflammation and apoptosis signaling may provide alternatives to the current clinical approaches to improve oxidative responses of endotoxemia. ..
  13. Bai R, Yin X, Feng X, Cao Y, Wu Y, Zhu Z, et al. Corydalis hendersonii Hemsl. protects against myocardial injury by attenuating inflammation and fibrosis via NF-?B and JAK2-STAT3 signaling pathways. J Ethnopharmacol. 2017;207:174-183 pubmed publisher
    ..CH extract exerted a protective effect against myocardial ischemic injury via inhibition of inflammation, myocardial fibrosis, and platelet aggregation...
  14. Elmallah M, Elkhadragy M, Al Olayan E, Abdel Moneim A. Protective Effect of Fragaria ananassa Crude Extract on Cadmium-Induced Lipid Peroxidation, Antioxidant Enzymes Suppression, and Apoptosis in Rat Testes. Int J Mol Sci. 2017;18: pubmed publisher
    ..Administration of SME debilitated the deleterious effect of cadmium via reduction of both LPO and NO levels followed by a significant enhancement in the gene expression level of CAT..
  15. Sobinoff A, Sutherland J, Beckett E, Stanger S, Johnson R, Jarnicki A, et al. Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility. Hum Reprod. 2014;29:2719-35 pubmed publisher
    ..In this study, 27 C57BL/6 5-week-old female mice were exposed via the nose-only to cigarette smoke (treatment) or 27 were exposed to room air (control) for 6 weeks before being ..
  16. Mao Z, Shen S, Wan Y, Sun W, Chen H, Huang M, et al. Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid. J Ethnopharmacol. 2015;173:256-65 pubmed publisher
    ..We have demonstrated that HKC, similar to LA, is renoprotective via attenuating OS and renal fibrosis in the DN rat model...
  17. Jacometo C, Zhou Z, Luchini D, Trevisi E, Corrêa M, Loor J. Maternal rumen-protected methionine supplementation and its effect on blood and liver biomarkers of energy metabolism, inflammation, and oxidative stress in neonatal Holstein calves. J Dairy Sci. 2016;99:6753-6763 pubmed publisher
    ..Liver was sampled (n=8 calves per diet) via biopsy on d 4, 14, 28, and 50 of age. Growth and health were not affected by maternal diet...
  18. Winter W, Flax S, Harris N. Coagulation Testing in the Core Laboratory. Lab Med. 2017;48:295-313 pubmed publisher
    ..Platelet-derived ADP and thromboxane activate non-adhered platelets via their GPIIb/IIIa receptors, allowing these platelets to participate in platelet aggregation...
  19. Yun S, Han Y, Lee J, Kim S, Lee S. Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78. Anticancer Res. 2017;37:2975-2984 pubmed
    ..GRP78 silencing and incubation with 5-FU have synergistic effects on the inhibition of LoVo colon cancer cell growth via the induction of ER stress-dependent apoptosis.
  20. Cai H, Su S, Li Y, Zeng H, Zhu Z, Guo J, et al. Protective effects of Salvia miltiorrhiza on adenine-induced chronic renal failure by regulating the metabolic profiling and modulating the NADPH oxidase/ROS/ERK and TGF-?/Smad signaling pathways. J Ethnopharmacol. 2018;212:153-165 pubmed publisher
    ..SMEE and SMWE can significantly alleviate adenine-induced CRF via regulation of the metabolic profiling and modulation of NADPH oxidase/ROS/ERK and TGF-?/Smad signaling pathways, ..
  21. Chang C, Ortiz K, Ansari A, Gershwin M. The Zika outbreak of the 21st century. J Autoimmun. 2016;68:1-13 pubmed publisher
    ..The virus was until recently believed to only be transmitted via mosquitoes...
  22. Traish A. Negative Impact of Testosterone Deficiency and 5?-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men. Adv Exp Med Biol. 2017;1043:473-526 pubmed publisher
    ..Testosterone (T) either directly or via its transformation into the more potent metabolite 5?-dihydrotestosterone (5?-DHT) or via aromatization into ..
  23. Khanra R, Dewanjee S, K Dua T, Sahu R, Gangopadhyay M, De Feo V, et al. Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response. J Transl Med. 2015;13:6 pubmed publisher
    ..Histological studies also supported the protective characteristics of AA. Results suggest that AA could offer prophylactic role against T2DM and its associated reno- and cardio- toxicity. ..
  24. Calderone V, Gallego J, Fernández Miranda G, Garcia Pras E, Maillo C, Berzigotti A, et al. Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease. Gastroenterology. 2016;150:982-97.e30 pubmed publisher
    ..of VEGF overexpression in liver and mesentery that promotes pathologic, but not physiologic, angiogenesis, via sequential and nonredundant functions of CPEB1 and CPEB4...
  25. Jing Y, Cai D, Chen Q, Xiong Q, Hu T, Yao Y, et al. Liuwei Dihuang soft capsules attenuates endothelial cell apoptosis to prevent atherosclerosis through GPR30-mediated regulation in ovariectomized ApoE-deficient mice. J Ethnopharmacol. 2017;208:185-198 pubmed publisher
    ..The three administered groups were given simvastatin (4mg/kg via i.g.) and LWDH (4.5, 9.0g/kg via i.g.) every day for 14 weeks...
  26. Xie J, Liu J, Chen T, Lan Q, Zhang Q, Liu B, et al. Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice. World J Gastroenterol. 2015;21:5473-81 pubmed publisher
    ..3% vs 20.0%, P < 0.0001), and SP600125 could inhibit the effect of DHM. These findings demonstrate that DHM alleviates CCl4-induced liver injury, suggesting that DHM is a promising candidate for reversing liver injury and ALF. ..
  27. Alessandra Perini J, Perini J, Rodrigues Baptista K, de Moura R, Junior A, Dos Santos T, et al. Euterpe oleracea extract inhibits tumorigenesis effect of the chemical carcinogen DMBA in breast experimental cancer. BMC Complement Altern Med. 2018;18:116 pubmed publisher
    ..Forty rats were randomized into two groups: treated with 200 mg/kg of either açaí extract or vehicle, via gastric tube for 16 consecutive weeks...
  28. Li F, Kakoki M, Smid M, Boggess K, Wilder J, Hiller S, et al. Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice. Hypertension. 2018;71:894-903 pubmed publisher
    ..cells, pharmacological doses of ET-1 increased the cellular sFlt1 transcripts and protein secretion via both type A and B ET-1 receptors...
  29. Li Z, Lin M, Liu C, Wang D, Shi X, Chen Z, et al. Fetuin-B links nonalcoholic fatty liver disease to type 2 diabetes via inducing insulin resistance: Association and path analyses. Cytokine. 2018;108:145-150 pubmed publisher
    ..Fetuin-B links NAFLD to T2D via inducing insulin resistance, and NAFLD contributes to the pathogenesis of T2D via multiple mechanisms.
  30. Lee A, Sung M, Kim W, Jung Y. COMP-angiopoietin-1 ameliorates inflammation-induced lymphangiogenesis in dextran sulfate sodium (DSS)-induced colitis model. J Mol Med (Berl). 2018;96:459-467 pubmed publisher
    ..Experimental colitis was induced in mice by administering 3% dextran sulfate sodium (DSS) via drinking water...
  31. Itoh T, Ono A, Kawaguchi K, Teraoka S, Harada M, Sumi K, et al. Phytol isolated from watermelon (Citrullus lanatus) sprouts induces cell death in human T-lymphoid cell line Jurkat cells via S-phase cell cycle arrest. Food Chem Toxicol. 2018;115:425-435 pubmed publisher
    ..Based on the data of in vitro and in vivo studies and previous studies, we suggest phytol as a potential therapeutic compound for cancer. ..
  32. Lomova M, Brichkina A, Kiryukhin M, Vasina E, Pavlov A, Gorin D, et al. Multilayer Capsules of Bovine Serum Albumin and Tannic Acid for Controlled Release by Enzymatic Degradation. ACS Appl Mater Interfaces. 2015;7:11732-40 pubmed publisher replace expensive and significantly cytotoxic positively charged polypeptides in biodegradable capsules formed via Layer-by-Layer (LbL) assembly, multilayers of bovine serum albumin (BSA) and tannic acid (TA) are obtained and ..
  33. Wang L, Liu A, Zhao Y, Mu X, Huang T, Gao H, et al. The levels of polycyclic aromatic hydrocarbons (PAHs) in human milk and exposure risk to breastfed infants in petrochemical industrialized Lanzhou Valley, Northwest China. Environ Sci Pollut Res Int. 2018;25:16754-16766 pubmed publisher
    ..In addition, the exposure risks of breastfed infants due to PAH ingestion via breast milk were assessed and the relative breast-feeding risk to the total intake dose of infants was addressed...
  34. Moy F, Loh D. Cardiometabolic risks profile of normal weight obese and multi-ethnic women in a developing country. Maturitas. 2015;81:389-93 pubmed publisher
    ..This was a cross-sectional study involving women recruited via multi-stage sampling from six states in Malaysia. Anthropometric and body composition analysis were performed...
  35. Mehaffey J, Charles E, Narahari A, Schubert S, Laubach V, Teman N, et al. Increasing circulating sphingosine-1-phosphate attenuates lung injury during ex vivo lung perfusion. J Thorac Cardiovasc Surg. 2018;156:910-917 pubmed publisher
    ..Elevation of circulating sphingosine-1-phosphate via specific pharmacologic modalities during ex vivo lung perfusion may provide endothelial protection in marginal ..
  36. Zhang X, Li X, Li X, Zheng L, Lei L. ANXA1 silencing increases the sensitivity of cancer cells to low-concentration arsenic trioxide treatment by inhibiting ERK MAPK activation. Tumori. 2015;101:360-7 pubmed publisher indicate that overexpression of ANXA1 induced by low-concentration ATO makes cancer cells more resistant to the agent via activated ERK MAPKs. Specific silencing of ANXA1 increased the sensitivity of cancer cells to ATO treatment.
  37. Hung M, Wu Y, Bamodu O, Chen X, Lin Y, HU P, et al. Activation of the monocytic α7 nicotinic acetylcholine receptor modulates oxidative stress and inflammation-associated development of coronary artery spasm via a p38 MAP-kinase signaling-dependent pathway. Free Radic Biol Med. 2018;120:266-276 pubmed publisher
    ..Our study suggests the potential role of α7-nAChR mRNA and/or protein expression as a diagnostic biomarker for CAS. ..
  38. Yuan Z, Li Q, Luo S, Liu Z, Luo D, Zhang B, et al. PPARγ and Wnt Signaling in Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells. Curr Stem Cell Res Ther. 2016;11:216-25 pubmed
    ..whereas the noncanonical Wnt pathway activates histone methyltransferases that inhibit PPARγ transactivation via histone H3 lysine 9 (H3K9) methylation of its target genes...
  39. Chan K, Pillon N, Sivaloganathan D, Costford S, Liu Z, Théret M, et al. Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK). J Biol Chem. 2015;290:16979-88 pubmed publisher
    ..These findings could have applicability to reverse obesity-linked inflammation in metabolically relevant tissues. ..
  40. Toshimitsu M, Kamei Y, Ichinose M, Seyama T, Imada S, Iriyama T, et al. Atomoxetine, a selective norepinephrine reuptake inhibitor, improves short-term histological outcomes after hypoxic-ischemic brain injury in the neonatal male rat. Int J Dev Neurosci. 2018;: pubmed publisher
    ..such as norepinephrine (NE) and glutamate, are involved in the pathogenesis of hypoxic-ischemic encephalopathy via the interaction between neurons and microglia...
  41. Shank J, Kelley B, Jackson J, Tweedie J, Franklin D, Damo S, et al. The Host Antimicrobial Protein Calgranulin C Participates in the Control of Campylobacter jejuni Growth via Zinc Sequestration. Infect Immun. 2018;86: pubmed publisher
    ..These results suggest that upon infection with C. jejuni, leukocytes trafficked to the intestine release calgranulin C as a mechanism for inhibiting C. jejuni growth. ..
  42. Bury A, Hellingwerf K. Design, characterization and in vivo functioning of a light-dependent histidine protein kinase in the yeast Saccharomyces cerevisiae. AMB Express. 2018;8:53 pubmed publisher
    ..This was first demonstrated via the light-induced alteration of the expression level of the mannosyl-transferase OCH1, via a translational-fusion ..
  43. Feng Z, He Z, Zhang B, Li Y, Guo J, Xu Y, et al. Adenovirus-mediated osteoprotegerin ameliorates cartilage destruction by inhibiting proteoglycan loss and chondrocyte apoptosis in rats with collagen-induced arthritis. Cell Tissue Res. 2015;362:187-99 pubmed publisher
    ..To establish the CIA model, Sprague Dawley rats were injected with bovine type II collagen solution subcutaneously via the tails...
  44. Hopster K, Hopster Iversen C, Geburek F, Rohn K, Kästner S. Temporal and concentration effects of isoflurane anaesthesia on intestinal tissue oxygenation and perfusion in horses. Vet J. 2015;205:62-8 pubmed publisher
    ..Surface probes were placed via median laparotomy on the serosal and mucosal site of the jejunum and the pelvic flexion of the colon...
  45. Laiguillon M, Courties A, Houard X, Auclair M, Sautet A, Capeau J, et al. Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis. Osteoarthritis Cartilage. 2015;23:1513-22 pubmed publisher
    ..Accordingly, high glucose enhanced IL-1β-induced inflammation in cultured chondrocytes via oxidative stress and the polyol pathway...
  46. Stevens S, Velten M, Youtz D, Clark Y, Jing R, Reiser P, et al. Losartan treatment attenuates tumor-induced myocardial dysfunction. J Mol Cell Cardiol. 2015;85:37-47 pubmed publisher
    ..Simultaneously, mice were administered Losartan (10mg/kg) daily via their drinking water...
  47. Schott S, Vallet S, Tower R, Noor S, Tiwari S, Schem C, et al. In vitro and in vivo toxicity of 5-FdU-alendronate, a novel cytotoxic bone-seeking duplex drug against bone metastasis. Invest New Drugs. 2015;33:816-26 pubmed publisher
    ..The coupling of an amino-bisphosphonate with an antimetabolite via an N-alkyl-bonding offers a new strategy for the preparation of amino-bisphosphonates conjugates with a cancer cell-..
  48. Hinwood A, Stasinska A, Callan A, Heyworth J, Ramalingam M, Boyce M, et al. Maternal exposure to alkali, alkali earth, transition and other metals: Concentrations and predictors of exposure. Environ Pollut. 2015;204:256-63 pubmed publisher
    ..alkali and alkaline earth metals in particular) in common use in electronics, defense industries, emitted via combustion and which are naturally present in the environment, that have received limited attention in terms of ..
  49. Sahoo R, Ansari M, Tuteja R, Tuteja N. Salt tolerant SUV3 overexpressing transgenic rice plants conserve physicochemical properties and microbial communities of rhizosphere. Chemosphere. 2015;119:1040-7 pubmed publisher
    ..the effects of transgenic plants on the physiology of non-targeted rhizospheric microbes and the food chain via causing adverse effects...
  50. Linnemann A, Neuman J, Battiola T, Wisinski J, Kimple M, Davis D. Glucagon-Like Peptide-1 Regulates Cholecystokinin Production in β-Cells to Protect From Apoptosis. Mol Endocrinol. 2015;29:978-87 pubmed publisher
    ..GLP-1 also protects β-cells from apoptosis via cAMP-mediated mechanisms...
  51. Bekki K, Vogel H, Li W, Ito T, Sweeney C, Haarmann Stemmann T, et al. The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells. Pestic Biochem Physiol. 2015;120:5-13 pubmed publisher
    ..Accordingly, our present study suggests that AhR plays a pivotal role in the development of breast cancer via the suppression of apoptosis, and provides an idea that the use of AhR antagonists with chemotherapeutic agents may ..
  52. Pivin E, Ponte B, Pruijm M, Ackermann D, Guessous I, Ehret G, et al. Inactive Matrix Gla-Protein Is Associated With Arterial Stiffness in an Adult Population-Based Study. Hypertension. 2015;66:85-92 pubmed publisher
    ..We recruited participants via a multicenter family-based cross-sectional study in Switzerland...
  53. Gurav A, Sivaprakasam S, Bhutia Y, Boettger T, Singh N, Ganapathy V. Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions. Biochem J. 2015;469:267-78 pubmed publisher
    ..We conclude that Slc5a8 is an obligatory link between dietary fibre and mucosal immune system via the bacterial metabolite butyrate and that this transporter is a conditional tumour suppressor in colon linked to ..
  54. Thongrangsalit S, Phaechamud T, Lipipun V, Ritthidej G. Bromocriptine tablet of self-microemulsifying system adsorbed onto porous carrier to stimulate lipoproteins secretion for brain cellular uptake. Colloids Surf B Biointerfaces. 2015;131:162-9 pubmed publisher
    ..Therefore, tablet of SME adsorbed onto porous carrier potentially delivered BM to brain via lymphatic transport by increasing the lipoprotein synthesis.
  55. Mironets E, Osei Owusu P, Bracchi Ricard V, Fischer R, Owens E, Ricard J, et al. Soluble TNF? Signaling within the Spinal Cord Contributes to the Development of Autonomic Dysreflexia and Ensuing Vascular and Immune Dysfunction after Spinal Cord Injury. J Neurosci. 2018;38:4146-4162 pubmed publisher
    ..This improvement is mediated via decreased sprouting of nociceptive primary afferents and activation of the spinal sympathetic reflex circuit...
  56. Stefanich E, Rae J, Sukumaran S, Lutman J, Lekkerkerker A, Ouyang W, et al. Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases. Biochem Pharmacol. 2018;152:224-235 pubmed publisher
    ..roles in infections and in inflammatory diseases that have been linked to its meditation of innate immunity via multiple mechanisms...
  57. Wu C, Gupta N, Huang Y, Zhang H, Alshareef A, Chow A, et al. Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma. BMC Cancer. 2018;18:361 pubmed publisher
    ..We have demonstrated that cancer cell plasticity exists in ALK+ALCL, a type of hematopoietic cancer. In this cancer type, the Wnt/β-catenin/MYC/Sox2 axis is an important regulator of cancer cell plasticity. ..
  58. Yu J, Li B, Chen X, Lü J, Wang D, Gu T, et al. Comparison of Immunogenicity and Protection of Two Pneumococcal Protein Vaccines Based on PsaA and PspA. Infect Immun. 2018;86: pubmed publisher
    ..In this study, we vaccinated mice via the subcutaneous (s.c...
  59. Kim J, Yang J, Han B, Kwon H, Kim J, Choi S. Protective Role of Apelin Against Cyclosporine-Induced Renal Tubular Injury in Rats. Transplant Proc. 2017;49:1499-1509 pubmed publisher
    ..Rats were given CsA (15 mg/kg/day) and/or apelin-13 (15 μg/kg/day) for 7 days via subcutaneous injection...
  60. Bertrand L, Toborek M. Dysregulation of Endoplasmic Reticulum Stress and Autophagic Responses by the Antiretroviral Drug Efavirenz. Mol Pharmacol. 2015;88:304-15 pubmed publisher
    ..studied drugs (efavirenz, tenofovir, emtricitabine, lamivudine, and indinavir), only efavirenz increased ER stress via upregulation and activation of protein kinase-like ER kinase PERK and inositol requiring kinase 1α (IRE1α)...
  61. Soares K, Urdapilleta A, Santos G, Carneiro A, Gomes C, Roselino A, et al. Field validation of a Leishmania (Leishmania) mexicana exo-antigens ELISA for diagnosing tegumentary leishmaniasis in regions of Leishmania (Viannia) predominance. Braz J Infect Dis. 2015;19:302-7 pubmed publisher
    ..It is believed that antigens released via secretion, excretion and metabolism are more specific than are antigens released by the lysis of Leishmania ..
  62. Bassi G, Brognara F, Castania J, Talbot J, Cunha T, Cunha F, et al. Baroreflex activation in conscious rats modulates the joint inflammatory response via sympathetic function. Brain Behav Immun. 2015;49:140-7 pubmed publisher
    ..These results reveal a novel physiological neuronal network controlling peripheral local inflammation. ..
  63. Liu G, Chen Y, Qi F, Jia L, Lu X, He T, et al. Specific chemotherapeutic agents induce metastatic behaviour through stromal- and tumour-derived cytokine and angiogenic factor signalling. J Pathol. 2015;237:190-202 pubmed publisher delineates the mechanism of chemotherapy-induced metastasis and provides novel therapeutic strategies to counterbalance pro-metastatic effects of chemo-drugs via combination treatment with anti-cytokine/anti-angiogenic therapy.
  64. Jia Z, Wang M, Wang X, Xu J, Wang L, Zhang H, et al. A Prokineticin (PK)-like cytokine from Chinese mitten crab Eriocheir sinensis promotes the production of hemocytes via reactive oxygen species. Fish Shellfish Immunol. 2018;77:419-428 pubmed publisher
    ..These results collectively suggested that EsAst should be a novel Astakine to promote the production of hemocytes in a ROS-dependent way in E. sinensis. ..
  65. Joshi M, Pant H, Liao N, Kim J, Kim H, Park C, et al. In-situ deposition of silver-iron oxide nanoparticles on the surface of fly ash for water purification. J Colloid Interface Sci. 2015;453:159-168 pubmed publisher
    In this study, a fly ash based composite, Ag-iron oxide/fly ash, was synthesized via a facile one-pot hydrothermal process using fly ash, ferrous chloride, and silver nitrate as precursors...
  66. Chang S, Hwang C, Yin J, Chen S, Yang D. Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons. Biochim Biophys Acta. 2015;1853:2306-25 pubmed publisher
    ..In conclusion, our findings indicated that OSM induces Mcl-1 expression via activation of ERK1/2, JAK1/2, STAT1/3, and CREB; furthermore, OSM-mediated Mcl-1 induction contributes to ..
  67. Van Tilburg M, Levy R, Walker L, Von Korff M, Feld L, Garner M, et al. Psychosocial mechanisms for the transmission of somatic symptoms from parents to children. World J Gastroenterol. 2015;21:5532-41 pubmed publisher
    To examine familial aggregation of irritable bowel syndrome (IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to stress...
  68. Zhang C, Zhu M, Chen D, Chen S, Zheng H. Organ preservation surgery for patients with T4a laryngeal cancer. Eur Arch Otorhinolaryngol. 2018;275:1601-1606 pubmed publisher
    ..supracricoid subtotal laryngectomy with unilateral or bilateral neck dissection, restoring laryngeal function via direct anastomosis of the cricoid cartilage and tongue base...
  69. Park J, Seo S, Park J, Jeon H, Kim J, Ryu S, et al. A murine colitis model developed using a combination of dextran sulfate sodium and Citrobacter rodentium. J Microbiol. 2018;56:272-279 pubmed publisher
    ..The CT group was supplied with normal drinking water for 7 days and subsequently infected with C. rodentium via oral gavage...
  70. Lee S, Lee H, Kwon J, Jung K, Kim S, Cho K, et al. A20 ameliorates inflammatory bowel disease in mice via inhibiting NF-?B and STAT3 activation. Immunol Lett. 2018;198:44-51 pubmed publisher
    ..These results suggest that A20 may inhibit the progression of colitis by decreasing inflammation via inhibition of NF-?B, phosphorylated STAT3, and IL-17.
  71. Tagetti A, Ericson U, Montagnana M, Danese E, Almgren P, Nilsson P, et al. Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: Possible interaction with genes involved in 20-HETE and EETs metabolism. Prostaglandins Other Lipid Mediat. 2015;120:126-33 pubmed publisher
    ..with complete phenotypic data), also considering the interaction with SNPs in genes involved in their metabolism via CYP450...
  72. Park M, Lee S, Kim E, Lee J, Jeong C, Park S. Effective Oocyte Vitrification and Survival Techniques for Bovine Somatic Cell Nuclear Transfer. Cell Reprogram. 2015;17:199-210 pubmed
    ..05). Spindle assessment via the Oosight Microscopy Imaging System and microtubule staining revealed that vitrified metaphase II oocytes (VT ..
  73. Laurenza A, Yang H, Williams B, Zhou S, Ferry J. Absence of Liver Toxicity in Perampanel-Treated Subjects: Pooled results from partial seizure phase III perampanel clinical studies. Epilepsy Res. 2015;113:76-85 pubmed publisher
    ..Some of the metabolites identified for perampanel are likely formed via reactive intermediates, which have the potential to covalently bind to protein and cause idiosyncratic toxicities, ..
  74. Park A, Lee G, Kim D, Jang E, Kwon H, Chi Y. Crystal structure of oleate hydratase from Stenotrophomonas sp. KCTC 12332 reveals conformational plasticity surrounding the FAD binding site. Biochem Biophys Res Commun. 2018;499:772-776 pubmed publisher
    ..To prevent this toxicity, unsaturated fatty acids should be converted into saturated fatty acids via hydrogenation reaction, which is the complete reduction of double bonds on the carbon chain...
  75. Ravishankar D, Watson K, Boateng S, Green R, Greco F, Osborn H. Exploring quercetin and luteolin derivatives as antiangiogenic agents. Eur J Med Chem. 2015;97:259-74 pubmed publisher
    ..As reports from others have suggested that structurally similar compounds can elicit biological responses via a non-specific, promiscuous membrane perturbation, potential interactions of the active compounds with a model ..
  76. Liu N, Li M, Gong Y, Liu F, Li T. Cytochrome P450s--Their expression, regulation, and role in insecticide resistance. Pestic Biochem Physiol. 2015;120:77-81 pubmed publisher
    ..Multiple P450 genes have been found to be co-overexpressed in individual insect species via several constitutive overexpression and induction mechanisms, which in turn are co-responsible for high levels of ..
  77. Pan Y, Zhou H, Zhou H, Hu M, Tang L. Apolipoprotein M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells. Drug Des Devel Ther. 2015;9:2375-82 pubmed publisher
    ..assays, we showed that ApoM positively regulated liver receptor homolog-1 (LRH-1) gene expression via direct binding to an LRH-1 promoter region (nucleotides -406/ -197)...
  78. Zhang X, Liu Q, Zhou W, Li P, Alolga R, Qi L, et al. A comparative proteomic characterization and nutritional assessment of naturally- and artificially-cultivated Cordyceps sinensis. J Proteomics. 2018;181:24-35 pubmed publisher the identification of 4 significantly changed metabolites, thus, lysine, threonine, serine, and arginine via untargeted metabolomics...
  79. Erickson N, Dietert K, Enders J, Glauben R, Nouailles G, Gruber A, et al. Soluble mucus component CLCA1 modulates expression of leukotactic cytokines and BPIFA1 in murine alveolar macrophages but not in bone marrow-derived macrophages. Histochem Cell Biol. 2018;149:619-633 pubmed publisher
    ..protein chloride channel regulator, calcium-activated 1, CLCA1, plays a role in inflammatory respiratory diseases via as yet unidentified pathways...
  80. Caimano M, Dunham Ems S, Allard A, Cassera M, Kenedy M, Radolf J. Cyclic di-GMP modulates gene expression in Lyme disease spirochetes at the tick-mammal interface to promote spirochete survival during the blood meal and tick-to-mammal transmission. Infect Immun. 2015;83:3043-60 pubmed publisher
    Borrelia burgdorferi, the Lyme disease spirochete, couples environmental sensing and gene regulation primarily via the Hk1/Rrp1 two-component system (TCS) and Rrp2/RpoN/RpoS pathways...
  81. Ayyagari R, Tang D, Patterson Lomba O, Zhou Z, Xie J, Chandiwana D, et al. Progression-free Survival With First-line Endocrine-based Therapies Among Postmenopausal Women With HR+/HER2- Metastatic Breast Cancer:: A Network Meta-analysis. Clin Ther. 2018;40:628-639.e3 pubmed publisher
    ..Pairwise hazard ratios and 95% credible intervals (CrIs) were obtained via a Bayesian NMA model...
  82. Ahmad I, Nisar H. Dosimetry perspectives in radiation synovectomy. Phys Med. 2018;47:64-72 pubmed publisher
    ..radionuclide is injected into the joint space, enabling controlled destruction of diseased synovial membrane via radiation exposure...
  83. Hahn N, Musters R, Fritz J, Pagano P, Vonk A, Paulus W, et al. Early NADPH oxidase-2 activation is crucial in phenylephrine-induced hypertrophy of H9c2 cells. Cell Signal. 2014;26:1818-24 pubmed publisher
    ..cardiomyoblasts (H9c2 cells) were incubated with 100 μM PE to induce hypertrophy after 24 and 48h as determined via cell and nuclear size measurements using digital imaging microscopy, electron microscopy and an automated cell ..
  84. Song R, Kidd L, Janssen A, Yosypiv I. Conditional ablation of the prorenin receptor in nephron progenitor cells results in developmental programming of hypertension. Physiol Rep. 2018;6:e13644 pubmed publisher
    ..Together, these data demonstrate that NPC PRR performs essential functions during nephrogenesis via control of hierarchy of genes that regulate critical cellular processes...
  85. Martínez Pinilla E, Rodríguez Pérez A, Navarro G, Aguinaga D, Moreno E, Lanciego J, et al. Dopamine D2 and angiotensin II type 1 receptors form functional heteromers in rat striatum. Biochem Pharmacol. 2015;96:131-42 pubmed publisher
    ..Heteromerization did not affect cAMP signaling via D2 receptors but attenuated the coupling of AT1 receptors to Gq...
  86. Wang L, Wang M, Li S, Wu H, Shen Q, Zhang S, et al. Nebulized lidocaine ameliorates allergic airway inflammation via downregulation of TLR2. Mol Immunol. 2018;97:94-100 pubmed publisher
    ..Taken together, the present study demonstrated that lidocaine prevented allergic airway inflammation via TLR2 in an OVA-induced murine allergic airway inflammation model...
  87. Lee D, Won K, Lee K, Jung S, Baek S, Chung H, et al. Angiotensin II facilitates neointimal formation by increasing vascular smooth muscle cell migration: Involvement of APE/Ref-1-mediated overexpression of sphingosine-1-phosphate receptor 1. Toxicol Appl Pharmacol. 2018;347:45-53 pubmed publisher
    ..These findings demonstrate that Ang II stimulates the epigenetic regulation of S1PR1 expression via H2O2-mediated APE/Ref-1 translocation, which may consequently be involved in Ang II-induced ..
  88. Li M, Qiu R, Tian G, Zhang X, Li C, Chen S, et al. Wenxin Keli for Ventricular premature complexes with Heart failure: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Complement Ther Med. 2017;33:85-93 pubmed publisher
    ..the methodological quality of the included studies by using criteria from the Cochrane Handbook, and analyzed via using Review Manager 5.3 software. Eight studies of WXKL were included...
  89. Abramowicz S, Kaban L, Wurtzel A, Roser S. Are oral and maxillofacial surgery residents being adequately trained to care for pediatric patients?. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124:220-224 pubmed publisher perform dentoalveolar procedures, outpatient anesthesia, orthognathic surgery, and alveolar bone grafts in pediatric procedures, but have limited experience with reconstruction of pediatric ramus-condyle unit via costochondral graft.
  90. Esposito P, Furini F, Gregorini M, Pattonieri E, Corradetti V, La Porta E, et al. Global Performance Status Score: A New Tool to Assess Physical Performance in Kidney Transplant Patients. Transplant Proc. 2017;49:1270-1275 pubmed publisher
    ..The results of these analyses were weighted to describe the different contribution of any single test, via the generation of a structural equation model, resulting in the definition of the GloPerSta...
  91. Zhang Y, Liu X, Bai X, Lin Y, Li Z, Fu J, et al. Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis. J Pineal Res. 2018;64: pubmed publisher
    ..Together, our results suggest that melatonin prevents endothelial cell pyroptosis via MEG3/miR-223/NLRP3 axis in atherosclerosis, and therefore, melatonin replacement might be considered a new strategy ..
  92. Chatelan A, Beer Borst S, Randriamiharisoa A, Pasquier J, Blanco J, Siegenthaler S, et al. Major Differences in Diet across Three Linguistic Regions of Switzerland: Results from the First National Nutrition Survey menuCH. Nutrients. 2017;9: pubmed publisher
    ..Trained dietitians assessed food consumption via two non-consecutive 24-h dietary recalls using the international validated software GloboDiet®...