Genomes and Genes
Gene Symbol: SELPLG
Description: selectin P ligand
Alias: CD162, CLA, PSGL-1, PSGL1, P-selectin glycoprotein ligand 1, cutaneous lymphocyte-associated associated antigen
Publications194 found, 100 shown here
- Expression cloning of a functional glycoprotein ligand for P-selectinD Sako
Genetics Institute, Small Molecule Drug Discovery Group, Cambridge, Massachusetts 02140
Cell 75:1179-86. 1993..A soluble ligand construct, when coexpressed with fucosyltransferase in COS cells, also mediates P-selectin binding and is immunocrossreactive with the major HL-60 glycoprotein that specifically binds P-selectin...
- Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flowG Woltmann
Division of Respiratory Medicine, University of Leicester School of Medicine, Glenfield Hospital, Leicester, UK
Blood 95:3146-52. 2000..This mechanism is likely to be a key event leading to the selective accumulation of eosinophils in allergic inflammation...
- A novel P-selectin glycoprotein ligand-1 monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectinK R Snapp
Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
Blood 91:154-64. 1998..Variation in tyrosine sulfation during B-cell differentiation may affect the ability of B cells to interact with P- and L-selectin...
- A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin bindingD Sako
Genetics Institute, Small Molecule Drug Discovery Group, Cambridge, Massachusetts 02140, USA
Cell 83:323-31. 1995..We propose that this sulfotyrosine-containing segment of PSGL-1, in conjunction with sLex presented on O-linked glycans, constitutes the high affinity P-selectin-binding site...
- Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropodJérémie Rossy
Department of Pathology, University of Bern, Bern, Switzerland
PLoS ONE 4:e5403. 2009..It was the goal of this study to investigate dynamic membrane microdomain reorganization during neutrophil activation...
- Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminusTakako Hirata
Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
J Biol Chem 279:51775-82. 2004..2 cells resulted in reduced chemotaxis to CCL27. These findings suggest a role for PSGL-1 in regulating chemokine-mediated responses, in addition to its role as a selectin ligand...
- Redistribution of P-selectin glycoprotein ligand-1 (PSGL-1) in chemokine-treated neutrophils: a role of lipid microdomainsSaotomo Itoh
Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
J Leukoc Biol 81:1414-21. 2007....
- The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivativesR S Peterson
Department of Biochemistry and Molecular Biology, University of Illinois at Chicago, College of Medicine, 60612 7334, USA
Mech Dev 69:53-69. 1997....
- Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectinAnne Leppanen
Department of Biochemistry and Molecular Biology, Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
J Biol Chem 278:26391-400. 2003..These results demonstrate that L-selectin binds with high affinity to the N-terminal region of PSGL-1 through cooperative interactions with three sulfated tyrosine residues and an appropriately positioned C2-O-sLex O-glycan...
- A juxta-membrane amino acid sequence of P-selectin glycoprotein ligand-1 is involved in moesin binding and ezrin/radixin/moesin-directed targeting at the trailing edge of migrating lymphocytesJuan M Serrador
Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
Eur J Immunol 32:1560-6. 2002..These results underline the role of moesin in the subcellular redistribution of PSGL-1 in lymphoid cells and make evident the importance of specific serine residues within the cytoplasmic tail of PSGL-1 for this process...
- P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophilsYan Qing Ma
University of Minnesota Medical School, MMC 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
Blood 104:2549-56. 2004P-selectin glycoprotein ligand 1 (PSGL-1, CD162) and integrin alphaMbeta2 (Mac-1, CD11bCD18) are leukocyte adhesion molecules essential for innate immunity and inflammation...
- Functional analysis of the combined role of the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase and dimerization of P-selectin glycoprotein ligand-1 in rolling on P-selectinMcRae J Smith
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA
J Biol Chem 279:21984-91. 2004..Both C2GlcNAcT-I glycosylation and PSGL-1 dimerization increased the rate of tethering to P-selectin under flow, whereas C2GlcNAcT-I levels primarily influenced tether bond strength...
- Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectinP P Wilkins
Departments of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
J Biol Chem 270:22677-80. 1995..These studies demonstrate that tyrosine sulfate on PSGL-1 functions in conjunction with sialylated and fucosylated glycans to mediate high affinity binding to P-selectin...
- Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectinF Li
W K Warren Medical Research Institute, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73140, USA
J Biol Chem 271:3255-64. 1996..These results demonstrate that PSGL-1 requires core 2 O-linked glycans that are sialylated and fucosylated to bind P- and E-selectin. PSGL-1 also requires tyrosine sulfate to bind P-selectin but not E-selectin...
- PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminusT Pouyani
Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
Cell 83:333-43. 1995..Rolling of HL-60 cells on P-selectin-coated coverslips is strongly attenuated by treatment of cells with an inhibitor of sulfation...
- The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamineK L Moore
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City
J Biol Chem 269:23318-27. 1994..These data suggest that PSGL-1 from human neutrophils displays complex, sialylated, and fucosylated O-linked poly-N-acetyllactosamine that promote high affinity binding to P-selectin, but not to E-selectin...
- Evolutionary conservation of P-selectin glycoprotein ligand-1 primary structure and functionBénédicte Baïsse
Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois, Bugnon 46, 1011 Lausanne, Switzerland
BMC Evol Biol 7:166. 2007....
- Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical studyO Simonetti
Clinica Dermatologica, Universita Politecnica delle Marche, Ospedale Regionale, Via Conca 20, 60020 Torrette, Ancona, Italy
Br J Dermatol 150:940-8. 2004..The cutaneous lymphocyte-associated antigen (CLA) and the skin-associated chemokine CCL27 highlight an important role for epithelial cells in controlling ..
- The role of the carrier protein and disulfide formation in the folding of beta-lactamase fusion proteins in the endoplasmic reticulum of yeastM Simonen
Institute of Biotechnology, University of Helsinki, Finland
J Biol Chem 269:13887-92. 1994..Fusion of beta-lactamase to the C terminus of hsp150 produced Cla-bla protein, which was secretion-competent but inactive...
- Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptorJ Yang
Center for Hemostasis and Thrombosis Research, Division of Hematology Oncology, New England Medical Center, Boston, MA, USA
Blood 87:4176-86. 1996..PSGL-1 on mouse myeloid cells is critical for high-affinity binding to P-selectin but not E-selectin...
- P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migrationT Hirata
Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Exp Med 192:1669-76. 2000..These data provide evidence that PSGL-1 on Th1 cells functions as one of the E-selectin ligands in vivo...
- Expression of HDL receptor, CLA-1 in human smooth-muscle cells and effect of interferon-gamma on its regulationH Imachi
First Department of Internal Medicine, Kagawa Medical University, Japan
Horm Metab Res 33:389-93. 2001..We previously identified human scavenger receptor BI (hSR-BI/CLA-1) as a receptor for human HDL, but did not examine the expression of hSR-BI/CLA-1 in smooth-muscle cells...
- Tonsillar B cells do not express PSGL-1, but a significant fraction displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activityD Armerding
Division of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, Mass, USA
Int Arch Allergy Immunol 126:78-90. 2001Skin-homing T cells are defined by the expression of the cutaneous lymphocyte-associated antigen (CLA) which enables the cells to selectively bind to vascular endothelial E-selectin close to sites of cutaneous inflammation, an initial ..
- Total lipids of Sarda sheep meat that include the fatty acid and alkenyl composition and the CLA and trans-18:1 isomersViviana Santercole
Faculty of Veterinary Medicine, University of Sassari, 07100, Sassari, Italy
Lipids 42:361-82. 2007..meat included the fatty acids from O-acyl and N-acyl lipids, including the trans- and conjugated linoleic acid (CLA) isomers and the alk-1-enyl ethers from the plasmalogenic lipids...
- Conjugated linoleic acid effects on circulating hormones, metabolites and lipoproteins, and its proportion in fasting serum and erythrocyte membranes of swineG I Stangl
Institut fur Ernahrungswissenschaften, Technische Universitat Munchen, Germany
Eur J Nutr 38:271-7. 1999Conjugated linoleic acids (CLA)# refer to a group of linoleic acid (18:2)-derived isomers with conjugated double bonds mostly at carbon atoms 9 and 11 or 10 and 12, and with all possible cis and trans combinations...
- Conjugated linoleic acid isomers reduce blood cholesterol levels but not aortic cholesterol accumulation in hypercholesterolemic hamstersThomas A Wilson
Department of Clinical Laboratory and Nutritional Sciences, Center for Health and Disease Research, University of Massachusetts Lowell, Lowell, Massachusetts 01854 5125, USA
Lipids 41:41-8. 2006..plasma lipids and lipoprotein cholesterol and glucose concentrations in hamsters fed either cis-9,trans-11 CLA (9c,11 tCLA); trans-10,cis-12 CLA (10t,12c CLA); or linoleic acid (LA) on the accumulation of aortic cholesterol in ..
- Effects of trans-10, cis-12 conjugated linoleic acid on ovine milk fat synthesis and cheese propertiesL A Sinclair
Animal Science Research Centre, Harper Adams University College, Edgmond, Newport, Shropshire, TF10 8NB, United Kingdom
J Dairy Sci 90:3326-35. 2007Trans-10, cis-12 conjugated linoleic acid (CLA) reduces milk fat synthesis in sheep in a manner similar to that seen in dairy cows, but its effects on cheese yield and flavor are unknown...
- Conjugated linoleic acid modulation of cell membrane in leukemia cellsGerhard Agatha
Friedrich Schiller University of Jena, Children s Hospital, Department of Pediatrics, Endocrinology and Metabolism, Kochstrasse 2, D 07745 Jena, Germany
Cancer Lett 209:87-103. 2004This study compared the cellular uptake of pure conjugated linoleic acid isomers (CLA(9c,11t) and CLA(9c,11c)) to linoleic acid (LA) and their effects on polyunsaturated fatty acid (PUFA) synthesis, its metabolism into conjugated long ..
- One-week therapy with pantoprazole versus ranitidine bismuth citrate plus two antibiotics for Helicobacter pylori eradicationJ P Gisbert
Department of Gastroenterology, Hospital de la Princessa, Universidad Autonoma de Madrid, Spain
Eur J Gastroenterol Hepatol 12:489-95. 2000..Our aim was to evaluate and to compare these two novel short-term triple therapies (Pan+Amo+Cla and RBC+Amo+Cla) for treatment of Helicobacter pylori.
- Evaluating the conjugated linoleic acid and trans 18:1 isomers in milk fat of dairy cows fed increasing amounts of sunflower oil and a constant level of fish oilC Cruz-Hernandez
Department of Agricultural, Food and Nutritional Science, University of Alberta, Alberta, 4 10 Agriculture Forestry Centre, Edmonton, Alberta, Canada, T6G 2P5
J Dairy Sci 90:3786-801. 2007..fat, and assess the content and composition of other trans-octadecenoic (trans-18:1) and conjugated linoleic acids (CLA) isomers...
- [Recurrent respiratory tract infection caused by Moraxella catarrhalis in patients with pneumoconiosis]A Omori
Department of Internal Medicine, Nagasaki University
Kansenshogaku Zasshi 73:311-7. 1999..Restriction enzyme analysis of chromosomal DNA by Hind III. Hae III, Cla I was performed on 50 strains of M. catarrhalis...
- Dietary conjugated linoleic acid protects against end stage disease of systemic lupus erythematosus in the NZB/W F1 mouseM Yang
Department of Animal Science, University of Wisconsin-Madison, 53706-1284, USA
Immunopharmacol Immunotoxicol 22:433-49. 2000Conjugated linoleic acid (CLA) is a naturally occurring fatty acid with anti-carcinogenic, anti-atherosclerotic and immune-enhancing activities...
- Conjugated linoleic acid and fish oil in laying hen diets: effects on egg fatty acids, thiobarbituric acid reactive substances, and tocopherols during storageG Cherian
Department of Animal Sciences, Oregon State University, Corvallis 97331, USA
Poult Sci 86:953-8. 2007The effects of incorporating conjugated linoleic acid (CLA) and fish oil in laying hen diets on egg CLA, n-3 fatty acid, tocopherol, and TBA reactive substances (TBARS) during 60 d of storage were investigated...
- Effect of conjugated linoleic acids from beef or industrial hydrogenation on growth and adipose tissue characteristics of ratsMao L He
Agriculture and Agri Food Canada, Lethbridge, Alberta, T1J 4B1, Canada
Nutr Metab (Lond) 6:19. 2009..abstract:..
- Lipase-catalyzed fractionation of conjugated linoleic acid isomersM J Haas
USDA, ARS, ERRC, Wyndmoor, Pennsylvania 19038, USA
Lipids 34:979-87. 1999..lipases produced by the fungus Geotrichum candidum to selectively fractionate mixtures of conjugated linoleic acid (CLA) isomers during esterification of mixed CLA free fatty acids and during hydrolysis of mixed CLA methyl esters were ..
- Effect of dietary conjugated linoleic acid on the quality characteristics of chicken eggs during refrigerated storageD U Ahn
Department of Animal Science, Iowa State University, Ames 50011 3150, USA
Poult Sci 78:922-8. 1999..5, or 5.0% conjugated linoleic acid (CLA). The diets were fed for 4 wk to determine the effect of dietary CLA on quality characteristics of eggs...
- The effect of dietary conjugated linoleic acid on egg yolk fatty acids and hatchability in Japanese quailR Aydin
Department of Animal Science, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey
Poult Sci 83:2016-22. 2004Conjugated linoleic acid (CLA) increased the ratio of saturated fatty acids to monounsaturated fatty acids in yolk and caused embryo mortality...
- Impairment of 8-iso-PGF(2ALPHA) isoprostane metabolism by dietary conjugated linoleic acid (CLA)Anna Iannone
Universita degli Studi di Modena e Reggio Emilia, Dipartimento di Scienze Biomediche, Via Campi 287, 41100 Modena, Italy
Prostaglandins Leukot Essent Fatty Acids 80:279-87. 2009..After its formation, it is promptly metabolized to 2,3 dinor (DIN) in peroxisomes. Conjugated linoleic acid (CLA) is preferentially beta-oxidized in peroxisomes which may compete with IP, and thereby may affect its metabolism...
- Comparative study of high-linoleic acid vegetable oils for the production of conjugated linoleic acidWhitney Gammill
Department of Food Science, University of Arkansas, 2650 Young Avenue, Fayetteville, Arkansas 72704, USA
J Agric Food Chem 58:2952-7. 2010Conjugated linoleic acid (CLA) is found in small quantities in dairy and beef products. Obtaining optimum dietary CLA levels from these sources requires an increased intake of saturated fat...
- Cutaneous lymphocyte antigen expression in benign and neoplastic cutaneous B- and T-cell lymphoid infiltratesCynthia M Magro
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
J Cutan Pathol 35:1040-9. 2008Cutaneous lymphocyte-associated antigen (CLA) is expressed in resident cutaneous T lymphocytes, high endothelial venules, peripheral monocytes, granulocytes and a small percentage of memory B cells...
- Effects of dietary supplementation of rumen-protected conjugated linoleic acid to grazing cows in early lactationS R Medeiros
Embrapa Beef Cattle, Campo Grande, Mato Grosso do Sul, Brazil
J Dairy Sci 93:1126-37. 2010Conjugated linoleic acids (CLA) are potent anticarcinogens in animal and in vitro models as well as inhibitors of fatty acid synthesis in mammary gland, liver, and adipose tissue...
- A down-regulatable E-selectin ligand is functionally important for PSGL-1-independent leukocyte-endothelial cell interactionsRenata C O Zanardo
Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1
Blood 104:3766-73. 2004..In conclusion, E-selectin mediates PSGL-1-dependent and independent rolling and the latter can be down-regulated by systemic activation and can replace PSGL-1 to support the development of inflammation...
- Effects of varying doses of supplemental conjugated linoleic acid on production and energetic variables during the transition periodL J Odens
The Department of Animal Sciences, University of Arizona, Tucson 85721, USA
J Dairy Sci 90:293-305. 2007Supplementing a high dose of dietary conjugated linoleic acid (CLA) inhibits milk fat synthesis in dairy cows immediately postpartum...
- Evidence that maternal conjugated linoleic acid negatively affects lipid uptake in late-stage chick embryos resulting in increased embryonic mortalityV A Leone
University of Wisconsin Madison, Animal Science Department, Madison, WI 53706, USA
Poult Sci 89:621-32. 2010An experiment was performed to determine the effect of maternal dietary conjugated linoleic acid (CLA) on growth and composition of surviving chick embryos and residual yolk sacs during the last week of development when lipid utilization ..
- The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjectsM M J W Kamphuis
Department of Human Biology, Faculty of Health Sciences, Maastricht University, The Netherlands
Int J Obes Relat Metab Disord 27:840-7. 2003To study the effects of 13 weeks conjugated linoleic acid (CLA) supplementation in overweight subjects after weight loss on weight regain, body composition, resting metabolic rate, substrate oxidation, and blood plasma parameters.
- Studies on the production of conjugated linoleic acid from linoleic and vaccenic acids by mixed rumen protozoaMamun M Or-Rashid
Department of Animal and Poultry Science, University of Guelph, Guelph, ON, N1G 2W1, Canada
Appl Microbiol Biotechnol 81:533-41. 2008..study was designed to investigate the capability of mixed rumen protozoa to synthesize conjugated linoleic acid (CLA) from linoleic (LA) and vaccenic acids (VA). Rumen contents were collected from fistulated cows...
- Trans-10,cis-12 conjugated linoleic acid suppresses the desaturation of linoleic and alpha-linolenic acids in HepG2 cellsKlaus Eder
Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
J Nutr 132:1115-21. 2002The objective of this study was to determine the effects of cis-9,trans-11 and trans-10,cis-12 CLA on the fatty acid desaturation in a human hepatoma cell line, HepG2...
- The effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obeseC Syvertsen
Scandinavian Clinical Research AS, Kjeller, Norway
Int J Obes (Lond) 31:1148-54. 2007Contradicting results have been published regarding the effect of conjugated linoleic acid (CLA) on insulin resistance...
- A conjugated linoleic acid supplement containing trans-10, cis-12 conjugated linoleic acid reduces milk fat synthesis in lactating goatsA L Lock
Department of Animal Science, University of Vermont, Burlington 05405, USA
J Dairy Sci 91:3291-9. 2008The effect of conjugated linoleic acid (CLA) supplements containing trans-10, cis-12 for reducing milk fat synthesis has been well described in dairy cows and sheep. Studies on lactating goats, however, remain inconclusive...
- Conjugated linoleic acid alters global gene expression in human intestinal-like Caco-2 cells in an isomer-specific mannerEileen F Murphy
Department of Food and Nutritional Sciences, University College, Cork, Ireland
J Nutr 137:2359-65. 2007Conjugated linoleic acid (CLA) exhibits isomer-specific effects on transepithelial calcium (Ca) transport as well as on cell growth in human intestinal-like Caco-2 cells. However, the molecular mechanisms of action are still unclear...
- Conjugated linoleic acid reduces adipose depots without reduction of stearoyl coenzyme A desaturase 1 gene expressionYun Hee Hwang
Department of Food and Nutrition, College of Natural Sciences, Duksung Women s University, Seoul, Korea
Ann Nutr Metab 51:126-33. 2007This study investigated the effects of conjugated linoleic acid (CLA) on the body weight, fat deposition and the expression of stearoyl coenzyme A desaturase 1 (SCD1) in the livers of male ICR mice that were fed with either beef tallow (..
- PSGL-1 function in immunity and steady state homeostasisDouglas A Carlow
The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
Immunol Rev 230:75-96. 2009..It is our purpose herein to review what is known, and not known, of PSGL-1 glycosylation and to update understanding of PSGL-1 functional scope...
- LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2Robert Ringseis
Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Str 26, D 06108 Halle Saale, Germany
Biochim Biophys Acta 1761:1235-43. 2006Conjugated linoleic acids (CLA) have attracted scientific interest due to their potential beneficial effects on atherosclerosis...
- Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggsG Cherian
Department of Animal Sciences, Oregon State University, Corvallis 97331 6702, USA
Poult Sci 81:1571-7. 2002We investigated the effect of dietary conjugated linoleic acid (CLA) along with n-3 polyunsaturated fatty acid (n-3 PUFA) on yolk fatty acid composition and volatile compounds in eggs that were raw (RA), hard-boiled (HB), or hard-boiled, ..
- Utilization of oil by-product from the purification process of conjugated linoleic Acid as feeding supplements for the accumulation of conjugated linoleic acid in the egg yolkJ H Kim
Department of Food and Biotechnology, Korea University, Chungnam, Korea
Poult Sci 87:64-70. 2008..efficient way to use oil by-product which is obtained during the purification process of conjugated linoleic acid (CLA) from safflower oil. The CLA by-product (CBP) was fed to the laying hens to accumulate CLA in the egg yolk...
- Purification and gene sequencing of conjugated linoleic acid reductase from a gastrointestinal bacterium, Butyrivibrio fibrisolvensS Fukuda
Department of Life Science, Meiji University, Kawasaki, Japan
J Appl Microbiol 103:365-71. 2007To characterize the cause for the lack of conjugated linoleic acid (CLA) reductase (CLA-R) activity in the Butyrivibrio fibrisolvens MDT-5 strain that rapidly isomerizes linoleic acid (LA) to CLA without hydrogenation, the CLA-R was ..
- Pharmacokinetics of rifampin and clarithromycin in patients treated for Mycobacterium ulcerans infectionJ W C Alffenaar
University Medical Center Groningen, University of Groningen, Department of Hospital and Clinical Pharmacy, P O Box 30 001, 9700 RB Groningen, The Netherlands
Antimicrob Agents Chemother 54:3878-83. 2010..for 8 weeks was compared with treatment with SM-RIF for 4 weeks followed by treatment with RIF-clarithromycin (CLA) for 4 weeks...
- Effects of conjugated linoleic acid (CLA) isomers on oxygen diffusion-concentration products in liposomes and phospholipid solutionsJun Jie Yin
Instrumentation and Biophysics Branch, CFSAN, US Food and Drug Administration, College Park, Maryland 20740, USA
J Agric Food Chem 54:7287-93. 2006..Liposomes and ethanol solutions were prepared by mixing synthetic phosphatidylcholines (PCs) with c9,t11-CLA, t10,c12-CLA, and linoleic acid (LA) in the sn-2 position into natural PCs from soybean, egg yolk, rat brain, and ..
- CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBDJosep Bassaganya-Riera
Laboratory of Nutritional Immunology and Molecular Nutrition, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
Clin Nutr 25:454-65. 2006Conjugated linoleic acid (CLA) and n-3 polyunsaturated fatty acids (PUFA) have been proposed as important pharmaco-nutrients for modulating mucosal immunity and therapeutic responses in patients with inflammatory bowel disease (IBD)...
- Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1Tatyana G Vishnyakova
NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:22771-80. 2003..b>Cla-1, the human SR-BI orthologue, was determined to be a LPS-binding protein and endocytic receptor mediating the ..
- Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophagesRobert Ringseis
Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle, Saale, Germany
J Nutr Biochem 19:594-603. 2008..linoleic acids (CLAs) are PPARgamma ligands and known to inhibit NF-kappaB via PPARgamma, we studied whether CLA isomers are capable of reducing gene expression and gelatinolytic activity of MMP-2 and -9 in PMA-differentiated ..
- Conjugated linoleic acid decreases prostaglandin synthesis in bovine luteal cells in vitroKatherine C P May
Department of Animal Sciences, Oregon State University, 112 Withycombe, Corvallis, OR 97331, USA
Mol Reprod Dev 78:328-36. 2011Feeding conjugated linoleic acids (CLA) improves reproductive performance in dairy cows; however, the molecular mechanisms by which CLA improves reproduction are not understood...
- Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acidTsuyoshi Tsuzuki
Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
J Nutr 136:2153-9. 2006..previously that alpha-eleostearic acid (alpha-ESA; 9Z11E13E-18:3) is converted to 9Z11E-conjugated linoleic acid (CLA) in rats through a Delta13-saturation reaction...
- Production of conjugated linoleic acid (CLA) by Bifidobacterium breve LMC520 and its compatibility with CLA-producing rumen bacteriaHui Gyu Park
Department of Food and Biotechnology, Korea University, Chungnam 339 700, Korea
J Agric Food Chem 59:984-8. 2011..was performed to characterize the ability of an active Bifidobacterium strain to produce conjugated linoleic acid (CLA) and to test its possible utilization as a probiotic compatible to the ruminal condition...
- Tyrosine sulfation of the amino terminus of PSGL-1 is critical for enterovirus 71 infectionYorihiro Nishimura
Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
PLoS Pathog 6:e1001174. 2010..Thus, the results presented in this study reveal that tyrosine sulfation, but not O-glycosylation, in the N-terminal region of PSGL-1 may facilitate virus entry and replication of EV71 in leukocytes...
- Decreased production of inflammatory mediators in human osteoarthritic chondrocytes by conjugated linoleic acidsChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
Lipids 39:161-6. 2004..This study examined the effect of CLA alone and in combination with other PUFA on the FA composition and the production of PGE2 and NO in OC cultures ..
- Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific mannerSeong Ho Lee
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
Carcinogenesis 27:972-81. 2006..The present study was performed to elucidate the molecular mechanism by which CLA stimulates anti-tumorigenic activity in human colorectal cancer (CRC) cells...
- Conjugated linoleic acid isomers and mammary cancer preventionClement Ip
Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Nutr Cancer 43:52-8. 2002There is increasing evidence that individual isomers of conjugated linoleic acid (CLA) may have unique biological or biochemical effects...
- Molecular and cellular effects of cis-9, trans-11-conjugated linoleic acid in enterocytes: effects on proliferation, differentiation, and gene expressionA Lampen
Institut für Lebensmitteltoxikologie, Stiftung Tierarztliche Hochschule Hannover, Germany
Biochim Biophys Acta 1735:30-40. 2005It has been hypothesized that dietary conjugated linoleic acids (CLA) may inhibit colon tumorigenesis...
- Surprising up-regulation of P-selectin glycoprotein ligand-1 (PSGL-1) in endotoxin-induced uveitisLama Almulki
Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
FASEB J 23:929-39. 2009..The temporal overlap between PSGL-1 and P-selectin up-regulation reveals an as yet unrecognized collaboration between this receptor-ligand pair, increasing efficiency of the first steps of the leukocyte recruitment cascade...
- Trans-9, cis-11 conjugated linoleic acid reduces milk fat synthesis in lactating dairy cowsJ W Perfield
Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
J Dairy Sci 90:2211-8. 2007..The first of these to be identified was trans-10, cis-12 conjugated linoleic acid (CLA), but others are postulated to contribute to diet-induced milk fat depression (MFD)...
- Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel diseaseJosep Bassaganya-Riera
Laboratory of Nutritional Immunology and Molecular Nutrition, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
Gastroenterology 127:777-91. 2004The molecular targets for the protective actions of conjugated linoleic acid (CLA) on experimental inflammatory bowel disease (IBD) are unknown...
- Effect of trans-10, cis-12 conjugated linoleic acid on performance, adipose depot weights, and liver weight in early-lactation dairy cowsD von Soosten
Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Bundesallee 50, 38116 Brunswick, Germany
J Dairy Sci 94:2859-70. 2011In feeding practice, conjugated linoleic acid (CLA) supplements are used to decrease milk fat excretion in early-lactation dairy cows to save energy to counteract the physiological negative energy balance...
- Involvement of PPAR gamma and E-cadherin/beta-catenin pathway in the antiproliferative effect of conjugated linoleic acid in MCF-7 cellsClaudia Bocca
Department of Experimental Medicine and Oncology, University of Torino, Torino, Italy
Int J Cancer 121:248-56. 2007Conjugated linoleic acid (CLA) is a naturally occurring fatty acid, which has been shown to exert beneficial effects against breast carcinogenesis...
- Effect of supplemental conjugated linoleic acids on heat-stressed brown swiss and holstein cowsC E Moore
Department of Animal Sciences, The University of Arizona, Tucson 85721, USA
J Dairy Sci 88:1732-40. 2005..Study objectives were to evaluate whether conjugated linoleic acids- (CLA-) induced milk fat depression (MFD) during heat stress would allow for increased milk and milk component synthesis...
- Detection of conjugated dienoic fatty acids in human vascular smooth muscle cells treated with conjugated linoleic acidAndre Muller
Institut fur Biochemie und Lebensmittelchemie, Universitat Hamburg, Grindelallee 117, D 20146 Hamburg, Germany
Biochim Biophys Acta 1737:145-51. 2005Conjugated linoleic acids (CLA) have attracted scientific interest due to their potential beneficial effects on atherosclerosis...
- Short communication: Postruminal infusion of conjugated linoleic acids negatively impacts milk synthesis in Holstein cowsJ A Bell
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
J Dairy Sci 86:1321-4. 2003In view of the potential of rumen-protected conjugated linoleic acid (CLA) as a means to increase the CLA content of bovine milk, a study was undertaken to evaluate the effect of synthetic CLA on milk production and composition...
- Influence of dietary oil content and conjugated linoleic acid (CLA) on lipid metabolism enzyme activities and gene expression in tissues of Atlantic salmon (Salmo salar L.)Sean R Kennedy
Institute of Aquaculture, University of Stirling, Stirling FK9 4LA, Scotland, United Kingdom
Lipids 41:423-36. 2006The overall objective is to test the hypothesis that conjugated linoleic acid (CLA) has beneficial effects in Atlantic salmon as a result of affecting lipid and FA metabolism...
- Effects of conjugated linoleic acid on growth, non-specific immunity, antioxidant capacity, lipid deposition and related gene expression in juvenile large yellow croaker (Larmichthys crocea) fed soyabean oil-based dietsRantao Zuo
The Key Laboratory of Mariculture Ministry of Education of China, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, People s Republic of China
Br J Nutr 110:1220-32. 2013The effects of conjugated linoleic acid (CLA) on growth performance, non-specific immunity, antioxidant capacity, lipid deposition and related gene expression were investigated in the large yellow croaker (Larmichthys crocea)...
- Functional comparison of SCARB2 and PSGL1 as receptors for enterovirus 71Seiya Yamayoshi
Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
J Virol 87:3335-47. 2013Human scavenger receptor class B, member 2 (SCARB2), and P-selectin glycoprotein ligand-1 (PSGL1) have been identified to be the cellular receptors for enterovirus 71 (EV71)...
- Modulation of nitric oxide and 6-keto-prostaglandin F(1alpha) production in bovine aortic endothelial cells by conjugated linoleic acidPaul Coen
Vascular Health Research Centre, School of Biotechnology, Faculty of Science and Health, Dublin City University, Glasnevin, ublin, Ireland
Endothelium 11:211-20. 2004Conjugated linoleic acid (CLA) refers to a group of polyunsaturated fatty acids that exist as positional (18:2) and stereo (cis/trans) isomers of conjugated dienoic octadecadienoate...
- Methods for analysis of conjugated linoleic acids and trans-18:1 isomers in dairy fats by using a combination of gas chromatography, silver-ion thin-layer chromatography/gas chromatography, and silver-ion liquid chromatographyCristina Cruz-Hernandez
Agriculture and Agri Food Canada, Food Research Program, 93 Stone Rd West, Guelph, Ontario, Canada
J AOAC Int 87:545-62. 2004Conjugated linoleic acids (CLA) are octadecadienoic acids (18:2) that have a conjugated double-bond system...
- cis-9, trans-11 CLA derived endogenously from trans-11 18:1 reduces cancer risk in ratsBenjamin A Corl
Department of Animal Science and Department of Food Science, Cornell University, Ithaca, NY 14853, USA
J Nutr 133:2893-900. 2003..the effects of increasing dietary levels of vaccenic acid (VA) and cis-9, trans-11 conjugated linoleic acid (CLA) on chemically induced mammary carcinogenesis in rats...
- Identification of rat cytochrome P450 forms involved in the metabolism of clausenamide enantiomersChuan Jiang Zhu
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, China
Chirality 15:448-55. 2003To identify which cytochrome P450 (CYP) isoform(s) are responsible for the metabolism of clausenamide (CLA) enantiomers in rats, effects of various CYP isoform inducers and inhibitors on the formation of CLA metabolites were investigated ..
- Improved identification of conjugated linoleic acid isomers using silver-ion HPLC separationsPierluigi Delmonte
U S Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740, USA
J AOAC Int 87:563-8. 2004..of most of the isomers of conjugated octadecadienoic acids (18:2), also known as conjugated linoleic acid (CLA)...
- trans-10,cis-12 conjugated linoleic acid enhances endurance capacity by increasing fatty acid oxidation and reducing glycogen utilization in miceJun Ho Kim
Department of Food Science, University of Massachusetts, 102 Holdsworth Way, Amherst, MA 01003, USA
Lipids 47:855-63. 2012The supplementation of conjugated linoleic acid (CLA) has been shown to improve endurance by enhancing fat oxidation during exercise in rodents and humans...
- Acute exposure of L6 myotubes to cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid isomers stimulates glucose uptake by modulating Ca2+/calmodulin-dependent protein kinase IISuresh K Mohankumar
Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
Int J Biochem Cell Biol 44:1321-30. 2012Conjugated linoleic acid (CLA), a dietary fat, has been considered beneficial in metabolic syndrome...
- Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71Yorihiro Nishimura
Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
Nat Med 15:794-7. 2009..Here we identify human P-selectin glycoprotein ligand-1 (PSGL-1; CD162), a sialomucin membrane protein expressed on leukocytes that has a major role in early stages of inflammation, as ..
- Effect of conjugated linoleic acid supplementation on body composition, body fat mobilization, protein accretion, and energy utilization in early lactation dairy cowsD von Soosten
Institute of Animal Nutrition, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Bundesallee 50, 38116 Brunswick, Germany
J Dairy Sci 95:1222-39. 2012..of the study was to investigate the effects of trans-10,cis-12 and cis-9,trans-11 conjugated linoleic acid (CLA) supplementation on body composition, mobilization or accretion of body fat and protein mass, as well as the energy ..
- The change in conjugated linoleic acid concentration in blood of Japanese fed a conjugated linoleic acid dietKenta Sato
Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, Sendai, Japan
J Nutr Sci Vitaminol (Tokyo) 57:364-71. 2011Conjugated linoleic acid (CLA) is a collective term used for fatty acids with a conjugated double bond that are geometrical and positional isomers of linoleic acid...
- Inter-organ proteomic analysis reveals insights into the molecular mechanisms underlying the anti-diabetic effects of cis-9, trans-11-conjugated linoleic acid in ob/ob miceVanessa Rungapamestry
Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK
Proteomics 12:461-76. 2012cis-9, trans-11-Conjugated linoleic acid (c9 t11 CLA) exerts anti-diabetic effects by improving systemic insulin sensitivity and inflammation. Levels of CLA in beef can be increased by feeding cattle on pasture...
- Complete downmodulation of P-selectin glycoprotein ligand in monocytes undergoing apoptosisJan Julius Stampfuss
Institut fur Pharmakologie, Universitat Duisburg Essen, Universitatsklinikum Essen, Hufelandstr 55, D 45122 Essen, Germany
Arterioscler Thromb Vasc Biol 28:1375-8. 2008..We have studied systematically the regulation of PSGL-1 expression and function in apoptotic monocytic cells...
- Dietary conjugated linoleic acid renal benefits and possible toxicity vary with isomer, dose and gender in rat polycystic kidney diseaseMalcolm R Ogborn
Department of Pediatrics and Child Health, University of Manitoba, JBRC513 715 McDermot Avenue, Winnipeg, MB, R3C 3P4, Canada
Lipids 43:783-91. 2008Conjugated linoleic acid (CLA) is anti-proliferative and anti-inflammatory in the Han:SPRD-cy rat model of kidney disease...
- Dietary conjugated linoleic acid improves antioxidant capacity in broiler chicksH J Zhang
Feed Research Institute of Chinese Academy of Agricultural Sciences, Beijing 100081, People s Republic of China
Br Poult Sci 49:213-21. 20081. The influence of dietary conjugated linoleic acid (CLA) on the antioxidant status in the absence or presence of endotoxin exposure was studied with male broiler chicks. 2...
- The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitusMartha A Belury
Department of Human Nutrition, The Ohio State University, Columbus, USA
J Nutr 133:257S-260S. 2003Isomers of conjugated linoleic acid (CLA) are found in beef, lamb and dairy products. Diets containing CLA reduce adipose mass in various depots of experimental animals...
- Beneficial effects of conjugated linoleic acid and exercise on bone of middle-aged female miceJameela Banu
Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
J Bone Miner Metab 26:436-45. 2008Conjugated linoleic acids (CLA) are a group of polyunsaturated fatty acids that has recently been shown to have several beneficial effects on different diseases, including prevention of bone loss...
- Impairment of glucose metabolism in mice induced by dietary oxidized frying oil is different from that induced by conjugated linoleic acidChun Huei Liao
Institute of Nutrition, China Medical University, Taichung, Taiwan
Nutrition 24:744-52. 2008..but induces glucose intolerance in rodents, a situation somewhat is similar to that in conjugated linoleic acid (CLA)-fed mice...
- Biopsied and vitrified bovine embryos viability is improved by trans10, cis12 conjugated linoleic acid supplementation during in vitro embryo cultureR M Pereira
Estação Zootécnica Nacional INIAP, 2005 048 Vale de Santarém, Portugal
Anim Reprod Sci 106:322-32. 2008..cryopreservation by supplementing serum-containing media with trans-10, cis-12 conjugated linoleic acid (t10, c12 CLA). The effect of t10, c12 CLA on lipid deposition and embryonic development was also tested...
- Frequent association between MEN 2A and cutaneous lichen amyloidosisUberta Verga
University of Milan, Ospedale Maggiore IRCCS, Italy
Clin Endocrinol (Oxf) 59:156-61. 2003..The presence of cutaneous lichen amyloidosis (CLA) has been anecdotally described in few families harbouring RET proto-oncogene mutation in codon 634...
- Modulation of body composition and immune cell functions by conjugated linoleic acid in humans and animal models: benefits vs. risksD S Kelley
Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California Davis, Davis, California 95616, USA
Lipids 38:377-86. 2003We have reviewed the published literature regarding the effects of CLA on body composition and immune cell functions in humans and in animal models...
- Evaluation of the mechanism of action of conjugated linoleic acid isomers on reproduction in dairy cowsE Castañeda-Gutiérrez
Department of Animal Science, Cornell University, Ithaca, NY 14853 6401, USA
J Dairy Sci 90:4253-64. 2007The objective of this study was to evaluate the mechanism of action through which conjugated linoleic acid (CLA) beneficially affects reproduction...
Research Grants111 found, 100 shown here
- Antiobesity Mechanism of CLA Isomer in Human AdipocytesMichael McIntosh; Fiscal Year: 2007..The objective of this application is to identify isomer-specific mechanisms by which conjugated linoleic acid (CLA), fatty acid (FA)s found in beef, dairy foods, and dietary supplements that decrease adiposity in certain animals ..
- Antiobesity Mechanism of CLA Isomer in Human AdipocytesMichael K McIntosh; Fiscal Year: 2010..The objective of this application is to identify isomer-specific mechanisms by which conjugated linoleic acid (CLA), fatty acid (FA)s found in beef, dairy foods, and dietary supplements that decrease adiposity in certain animals ..
- Antiobesity Mechanism of CLA Isomer in Human AdipocytesMichael McIntosh; Fiscal Year: 2009..The objective of this application is to identify isomer-specific mechanisms by which conjugated linoleic acid (CLA), fatty acid (FA)s found in beef, dairy foods, and dietary supplements that decrease adiposity in certain animals ..
- Antiobesity Mechanism of CLA Isomer in Human AdipocytesMichael McIntosh; Fiscal Year: 2009
- Antiobesity Mechanism of CLA Isomer in Human AdipocytesMichael K McIntosh; Fiscal Year: 2010
- Skin Cancer Prevention by Dietary Fatty AcidsPhilippe Thuillier; Fiscal Year: 2007..In particular, dietary studies with conjugated linoleic acid (CLA) in a mouse two-stage initiation-promotion skin carcinogenesis protocol resulted in a decreased number of tumors...
- Antiobesity Mechanism of CLA Isomer in Human AdipocytesMichael McIntosh; Fiscal Year: 2002..The objective of this application is to identify isomerspecific mechanisms by which conjugated linoleic acid (CLA), unsaturated fatty acids found in beef and dairy foods that reduce adiposity in certain animals and humans, alters ..
- ADJUVANT NUTRITION IN CHEMOTHERAPEUTIC RESPONSEStephanie Muga; Fiscal Year: 2002..that a diet enriched in chemopreventive factors (folate, calcium, vitamin D, and conjugated linoleic acid (CLA)) will potentiate the therapeutic ratio of FUra in the Apc Min/+ mouse...
- Skin Cancer Prevention by Dietary Fatty AcidsPhilippe Thuillier; Fiscal Year: 2007..In particular, dietary studies with conjugated linoleic acid (CLA) in a mouse two-stage initiation-promotion skin carcinogenesis protocol resulted in a decreased number of tumors...
- MINORITY PREDOCTORAL FELLOWSHIP PROGRAMArion Kennedy; Fiscal Year: 2007..objective of this application is to identify upstream signals produced by an isomer of conjugated linoleic acid (CLA), fatty acids found in beef and dairy products and in dietary supplements for weight loss, that activate cell ..
- CONJUGATED LINOLEIC AND OXIDATIVE LIPID METABOLISMARTHUR BULL; Fiscal Year: 2001..potential mechanisms of action by which a naturally occurring isomer of linoleic acid, conjugated linoleic acid (CLA), inhibits carcinogenesis...
- Benefits of conjugated linoleic acid on agingGabriel Fernandes; Fiscal Year: 2007..In recent years, there has been a growing interest in conjugated linoleic acid (CLA) as a possible dietary supplement to reduce obesity...
- Mechanisms for Blood Cell Adhesion Under FlowRODGER PAUL MCEVER; Fiscal Year: 2010..This information obtained may offer new methods to treat excessive blood cell adhesion in heart attacks, strokes, deep venous thrombosis, and other disorders. ..
- Procoagulant Microparticles: Novel Determinants of Venous ThrombosisThomas Wakefield; Fiscal Year: 2007..Lay Summary: This proposal will determine the role of procoagulant elements termed microparticles in the etiology of venous thrombosis and their use as a diagnostic tool. ..
- Procoagulant Microparticles: Novel Determinants of Venous ThrombosisTHOMAS WILLIAM WAKEFIELD; Fiscal Year: 2011..Lay Summary: This proposal will determine the role of procoagulant elements termed microparticles in the etiology of venous thrombosis and their use as a diagnostic tool. ..
- Distinction of skin homing T cells that bind P-selectinBruce Walcheck; Fiscal Year: 2004..The cutaneous lymphocyte-associated antigen (CLA) distinguishes human T cells that selectively home to the skin...
- Role of Vascular Heterogeneity in ThrombosisBarbara Furie; Fiscal Year: 2006..abstract_text> ..
- E-SELECTIN LIGANDS ON LYMPHOCYTESMark Jutila; Fiscal Year: 2001..The results of these studies may reveal new approaches to development of specific inhibitors that can selectively target neutrophil versus lymphocyte recruitment to sites of inflammation involving either P-selectin or E-selectin. ..
- Selectins and their ligands in leukocyte traffickingErik Vandendries; Fiscal Year: 2005....
- Selectin Control of Leukocyte Adhesion in ShearMichael Lawrence; Fiscal Year: 2006..Such insight may lead to identification of more effective molecular targets for anti-inflammatory therapeutics. ..
- PEGylation of a Glycosulfopeptide Anti-InflammatoryZIAD KAWAR; Fiscal Year: 2004..This work will lead to a SBIR Phase II application to use PEG-Glysopep in animal models of disease in preparation for filing an Investigational New Drug application with the Food and Drug Administration. ..
- SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLAThomas Kupper; Fiscal Year: 2006..g., lung, gut). These markers include Cutaneous Lymphocyte antigen (CLA, a ligand for E and P selectin which we characterized extensively in the first cycle of funding), the chemokine ..
- Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 SignalingJian Guo Geng; Fiscal Year: 2009..P-selectin (CD62P), P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and beta2-integrins are endothelial and leukocyte cell adhesion molecules essential for innate immunity and ..
- Cellular Regulation of Selectin-Ligand InteractionsRODGER PAUL MCEVER; Fiscal Year: 2010..Because excessive recruitment of leukocytes contributes to many diseases, including heart attacks and strokes, understanding how cells regulate adhesion receptors may suggest new therapeutic strategies. ..
- Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 SignalingJian Guo Geng; Fiscal Year: 2010..P-selectin (CD62P), P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and beta2-integrins are endothelial and leukocyte cell adhesion molecules essential for innate immunity and ..
- Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 SignalingJian Guo Geng; Fiscal Year: 2007..P-selectin (CD62P), P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and beta2-integrins are endothelial and leukocyte cell adhesion molecules essential for innate immunity and ..
- Novel Therapeutic Targets for Venous ThromboembolismTHOMAS WILLIAM contact WAKEFIELD; Fiscal Year: 2010..We will also develop new agents to target these molecules for the prevention and treatment of venous thrombosis. ..
- Novel Therapeutic Targets for Venous ThromboembolismThomas Wakefield; Fiscal Year: 2009..We will also develop new agents to target these molecules for the prevention and treatment of venous thrombosis. ..
- Molecular Basis For Functional Diversity Of PSGL-1KAREN SNAPP; Fiscal Year: 2005....
- DRUG RESISTANCE AND GENE TRANSFER IN H PYLORIDouglas Berg; Fiscal Year: 2003..The two most widely used types of therapies against HP depend on metronidazole (Mtz) or clarithromycin (Cla), in combination with other agents, but resistance (R) to Mtz is common, and CIaR is also known...