Gene Symbol: SEC23A
Description: Sec23 homolog A, coat complex II component
Alias: CLSD, hSec23A, protein transport protein Sec23A, SEC23-related protein A, Sec23 homolog A, COPII coat complex component
Species: human
Products:     SEC23A

Top Publications

  1. Szczyrba J, Nolte E, Wach S, Kremmer E, Stöhr R, Hartmann A, et al. Downregulation of Sec23A protein by miRNA-375 in prostate carcinoma. Mol Cancer Res. 2011;9:791-800 pubmed publisher
    ..1- and 4.5-fold, respectively. A computational analysis predicted the 3'-UTR of the SEC23A gene as a potential target for both miR-375 and miR-200c...
  2. Stagg S, LaPointe P, Razvi A, Gurkan C, Potter C, Carragher B, et al. Structural basis for cargo regulation of COPII coat assembly. Cell. 2008;134:474-84 pubmed publisher
    ..The COPII coat structure leads us to propose a mechanism by which cargo drives cage assembly and membrane curvature for budding from the ER. ..
  3. Bi X, Mancias J, Goldberg J. Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31. Dev Cell. 2007;13:635-45 pubmed
    ..Substitution of the corresponding residue F382L in human Sec23A causes cranio-lenticulo-sutural dysplasia, and we suggest that this mutation disrupts the nucleation of COPII coat ..
  4. Boyadjiev S, Fromme J, Ben J, Chong S, Nauta C, Hur D, et al. Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking. Nat Genet. 2006;38:1192-7 pubmed
    ..1). Here we show, using a positional cloning approach, that an F382L amino acid substitution in SEC23A segregates with this syndrome...
  5. Jiang X, Kiel D, Kraft P. The genetics of vitamin D. Bone. 2018;: pubmed publisher
    ..genome-wide association studies (GWAS) have discovered associations of GC, NADSYN1/DHCR7, CYP2R1, CYP24A1, SEC23A, AMDHD1 with serum levels of vitamin D...
  6. Sun Z, Zhou S, Tang J, Ye T, Li J, Liu D, et al. Sec23a mediates miR-200c augmented oligometastatic to polymetastatic progression. EBioMedicine. 2018;37:47-55 pubmed publisher
    ..The effects of miR-200c and Sec23a on tumor metastasis were verified both in vitro and in vivo...
  7. Covington J, Galgani J, Moro C, Lagrange J, Zhang Z, Rustan A, et al. Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation. PLoS ONE. 2014;9:e91675 pubmed publisher
    Lipid droplet-associated proteins such as perilipin 3 (PLIN3) and coatomer GTPase proteins (GBF1, ARF1, Sec23a, and ARFRP1) are expressed in skeletal muscle but little is known so far as to their regulation of lipolysis...
  8. Urai Y, Yamawaki M, Watanabe N, Seki Y, Morimoto T, Tago K, et al. Pull down assay for GTP-bound form of Sar1a reveals its activation during morphological differentiation. Biochem Biophys Res Commun. 2018;503:2047-2053 pubmed publisher
    ..Here we show that the C-terminal, but not the N-terminal, regions of Sec23A and Sec23B, the effector proteins of Sar1a, specifically bind to the active, GTP-bound form of Sar1a...
  9. Korpal M, Ell B, Buffa F, Ibrahim T, Blanco M, Celià Terrassa T, et al. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med. 2011;17:1101-8 pubmed publisher
    ..miR-200s promote metastatic colonization partly through direct targeting of Sec23a, which mediates secretion of metastasis-suppressive proteins, including Igfbp4 and Tinagl1, as validated by ..

More Information


  1. Garbes L, Kim K, Rieß A, Hoyer Kuhn H, Beleggia F, Bevot A, et al. Mutations in SEC24D, encoding a component of the COPII machinery, cause a syndromic form of osteogenesis imperfecta. Am J Hum Genet. 2015;96:432-9 pubmed publisher
    ..CLSD is caused by SEC23A mutations and displays a largely overlapping craniofacial phenotype, but it is not characterized by generalized ..
  2. Covington J, Bajpeyi S, Moro C, Tchoukalova Y, Ebenezer P, Burk D, et al. Potential effects of aerobic exercise on the expression of perilipin 3 in the adipose tissue of women with polycystic ovary syndrome: a pilot study. Eur J Endocrinol. 2015;172:47-58 pubmed publisher
    ..05), along with coatomers ARF1, ARFRP1, ?COP, and SEC23A (all P<0.05)...
  3. Khoriaty R, Hesketh G, Bernard A, Weyand A, Mellacheruvu D, Zhu G, et al. Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo. Proc Natl Acad Sci U S A. 2018;115:E7748-E7757 pubmed publisher
    ..SEC23, a core component of coat protein-complex II (COPII), is encoded by two paralogous genes in vertebrates (Sec23a and Sec23b)...
  4. Bruno J, Brumfield A, Chaudhary N, Iaea D, McGraw T. SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. J Cell Biol. 2016;214:61-76 pubmed publisher
    ..However, our data support a role for SEC23A, but not the other COPII components SEC13, SEC23B, and SEC31, in the insulin stimulation of GLUT4 trafficking, ..
  5. Zhu M, Tao J, Vasievich M, Wei W, Zhu G, Khoriaty R, et al. Neural tube opening and abnormal extraembryonic membrane development in SEC23A deficient mice. Sci Rep. 2015;5:15471 pubmed publisher
    ..Higher eukaryotes have two or more paralogs of most COPII components. Here we characterize mice deficient for SEC23A and studied interactions of Sec23a null allele with the previously reported Sec23b null allele...
  6. Jiang X, O Reilly P, Aschard H, Hsu Y, Richards J, Dupuis J, et al. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nat Commun. 2018;9:260 pubmed publisher
    ..7×10-9 at rs8018720 in SEC23A, and P = 1.9×10-14 at rs10745742 in AMDHD1)...
  7. Han J, Li E, Chen L, Zhang Y, Wei F, Liu J, et al. The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature. 2015;524:243-6 pubmed publisher
    ..CRTC2 competes with Sec23A, a subunit of the COPII complex, to interact with Sec31A, another COPII subunit, thus disrupting SREBP1 transport...
  8. Gan W, Zhang C, Siu K, Satoh A, Tanner J, Yu S. ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic. BMC Cell Biol. 2017;18:22 pubmed publisher
    ..In this study, we identified Sec23A, a component of the COPII vesicle coat, as a target of ULK1 phosphorylation...
  9. Mackenzie K, Lim Y, Duffield M, Chataway T, Zhou X, Keating D. Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins. Cell Signal. 2017;35:176-187 pubmed publisher
    ..were identified by mass spectrometry have trafficking-related functions and include the clathrin light chain B and Sec23A, an ER to Golgi trafficking vesicle coat component...
  10. Khoriaty R, Everett L, Chase J, Zhu G, Hoenerhoff M, McKnight B, et al. Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice. Sci Rep. 2016;6:27802 pubmed publisher
    ..Mammalian genomes contain two Sec23 paralogs, Sec23A and Sec23B. The encoded proteins share ~85% amino acid sequence identity...
  11. Furfari A, Wan B, Ding K, Wong A, Zhu L, Bezjak A, et al. Genetic biomarkers associated with pain flare and dexamethasone response following palliative radiotherapy in patients with painful bone metastases. Ann Palliat Med. 2017;6:S240-S247 pubmed publisher
    ..biosynthesis (DHODH, PECR), lipid excretion and metabolism (UGT2A1/2, VLDLR), and intracellular signalling (DNM2, SEC23A)...
  12. Palmer K, Konkel J, Stephens D. PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport. J Cell Sci. 2005;118:3839-47 pubmed
    ..These data show a role for PCTAIRE protein kinase function in membrane traffic through the early secretory pathway...
  13. Tang B, Kausalya J, Low D, Lock M, Hong W. A family of mammalian proteins homologous to yeast Sec24p. Biochem Biophys Res Commun. 1999;258:679-84 pubmed
    ..The Sec24 sequences also share weak but significant homology to the mammalian Sec23A and Sec23B. Northern blot analysis revealed that Sec24C is ubiquitously expressed...
  14. Ma W, Goldberg J. TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats. Proc Natl Acad Sci U S A. 2016;113:10061-6 pubmed publisher
  15. Townley A, Feng Y, Schmidt K, Carter D, Porter R, Verkade P, et al. Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development. J Cell Sci. 2008;121:3025-34 pubmed publisher
  16. Watson P, Forster R, Palmer K, Pepperkok R, Stephens D. Coupling of ER exit to microtubules through direct interaction of COPII with dynactin. Nat Cell Biol. 2005;7:48-55 pubmed
    ..Together, our data suggest a mechanism by which membranes of the early secretory pathway can be linked to motors and microtubules for subsequent organization and movement to the Golgi apparatus...
  17. Amodio G, Venditti R, De Matteis M, Moltedo O, Pignataro P, Remondelli P. Endoplasmic reticulum stress reduces COPII vesicle formation and modifies Sec23a cycling at ERESs. FEBS Lett. 2013;587:3261-6 pubmed publisher
    ..Here, we show that membrane association of COPII components, and in particular of Sec23a, is impaired by ER stress-inducing agents suggesting the existence of a dynamic interplay between protein folding ..
  18. Li C, Zhao L, Chen Y, He T, Chen X, Mao J, et al. MicroRNA-21 promotes proliferation, migration, and invasion of colorectal cancer, and tumor growth associated with down-regulation of sec23a expression. BMC Cancer. 2016;16:605 pubmed publisher
    ..After analyzing the expression of miR-21 and Sec23A in CRC cell lines, we transfected the highest miR-21 expressing cell line, SW-480, with a plasmid containing an ..
  19. Cho S, Ryoo J, Jun Y, Ahn K. Receptor-mediated ER export of human MHC class I molecules is regulated by the C-terminal single amino acid. Traffic. 2011;12:42-55 pubmed publisher
    ..Together, our results strongly suggest that ER export of human classical MHC-I molecules can occur via a receptor-mediated process dictated by a highly conserved ER export signal. ..
  20. Paccaud J, Reith W, Carpentier J, Ravazzola M, Amherdt M, Schekman R, et al. Cloning and functional characterization of mammalian homologues of the COPII component Sec23. Mol Biol Cell. 1996;7:1535-46 pubmed
    ..cDNA library with a probe derived from a partial SEC23 mouse homologue and isolated two different cDNA clones (hSec23A and hSec23B) encoding proteins of a predicted molecular mass of 85 kDa...
  21. Wang Y, Lieberman R, Pan J, Zhang Q, Du M, Zhang P, et al. miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1. Mol Cancer. 2016;15:70 pubmed
    ..Lastly, we utilized qRT-PCR and Western blot assay to examine two miR-375 target genes, SEC23A and YAP1, for their expression changes after miR-375 transfection...
  22. Dudognon P, Maeder Garavaglia C, Carpentier J, Paccaud J. Regulation of a COPII component by cytosolic O-glycosylation during mitosis. FEBS Lett. 2004;561:44-50 pubmed
    ..These data suggest that when entering into mitosis, the COPII component Sec24p is simultaneously deglycosylated and phosphorylated, a process which may contribute to the observed mitotic ER-to-Golgi traffic block. ..
  23. Russo R, Langella C, Esposito M, Gambale A, Vitiello F, Vallefuoco F, et al. Hypomorphic mutations of SEC23B gene account for mild phenotypes of congenital dyserythropoietic anemia type II. Blood Cells Mol Dis. 2013;51:17-21 pubmed publisher
    ..We propose a mechanism of compensation SEC23A-mediated which justifies these observations.
  24. Law R, Law H, Scurll J, Scholz R, Santos A, Shames S, et al. Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors. J Proteome Res. 2016;15:1613-22 pubmed publisher
  25. la Cour J, Schindler A, Berchtold M, Schekman R. ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex. PLoS ONE. 2013;8:e75309 pubmed publisher
    ..These results introduce a regulatory role for ALG-2/Ca(2+) in COPII tethering and vesicle budding. ..
  26. Bertrand J, Goichon A, Chan P, Azhar S, Lecleire S, Donnadieu N, et al. Enteral glutamine infusion modulates ubiquitination of heat shock proteins, Grp-75 and Apg-2, in the human duodenal mucosa. Amino Acids. 2014;46:1059-67 pubmed publisher
    ..Grp75 has protective and anti-inflammatory properties, while Apg-2 indirectly regulates stress-induced cell survival and proliferation through interaction with ZO-1. Further studies should confirm these results in stress conditions. ..
  27. Lassalle S, Zangari J, Popa A, Ilie M, Hofman V, Long E, et al. MicroRNA-375/SEC23A as biomarkers of the in vitro efficacy of vandetanib. Oncotarget. 2016;7:30461-78 pubmed publisher
    ..This approach identified SEC23A as a bona fide miR-375 target, which we validated by immunoblotting and immunohistochemistry of non-tumor and ..
  28. Bhattacharyya D, Glick B. Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization. Mol Biol Cell. 2007;18:839-49 pubmed
    ..Immunoprecipitation data indicate that Sec16L and Sec16S are each present at multiple copies in a heteromeric complex. We infer that mammalian cells have preserved and extended the function of Sec16. ..
  29. Boyadjiev S, Justice C, Eyaid W, McKusick V, Lachman R, Chowdry A, et al. A novel dysmorphic syndrome with open calvarial sutures and sutural cataracts maps to chromosome 14q13-q21. Hum Genet. 2003;113:1-9 pubmed
    ..The unique clinical phenotype and the mapping data suggest that this family represents a novel autosomal recessive syndrome. ..
  30. Ishikura Kinoshita S, Saeki H, Tsuji Naito K. BBF2H7-mediated Sec23A pathway is required for endoplasmic reticulum-to-Golgi trafficking in dermal fibroblasts to promote collagen synthesis. J Invest Dermatol. 2012;132:2010-8 pubmed publisher
    ..We demonstrate herein that the BBF2 human homolog on chromosome 7 (BBF2H7)-mediated Sec23A pathway is involved in regulation of intracellular procollagen trafficking...
  31. Jackson T, Kotermanski S, Kochanek P. Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons. Neuroscience. 2017;361:93-107 pubmed publisher
    ..neurons transduced with lentivirus to deliver control (non-targeting) shRNA. The mRNA levels of Sec23A (involved in ER-Golgi transport) and the small GTPase Rab4a (involved in endocytosis/protein trafficking) were ..
  32. Bai D, Chen P, Jin S, Qian J, Jiang G. Vagus nerve-preserving versus conventional laparoscopic splenectomy and azygoportal disconnection. Surg Endosc. 2018;32:2696-2703 pubmed publisher
    Conventional open and conventional laparoscopic splenectomy and azygoportal disconnection (CLSD) result in poor quality of life because of damage to the vagal nerve...
  33. Boyadjiev S, Kim S, Hata A, Haldeman Englert C, Zackai E, Naydenov C, et al. Cranio-lenticulo-sutural dysplasia associated with defects in collagen secretion. Clin Genet. 2011;80:169-76 pubmed publisher
    ..The CLSD locus was mapped to chromosome 14q13-q21 and a homozygous SEC23A F382L missense mutation was identified in the original family...
  34. Cox N, Unlu G, Bisnett B, Meister T, Condon B, Luo P, et al. Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway. Biochemistry. 2018;57:91-107 pubmed publisher
    ..In particular, we show that individual O-GlcNAcylation sites of SEC23A, an essential COPII component, are required for its function in human cells and vertebrate development, because ..
  35. Tomoishi S, Fukushima S, Shinohara K, Katada T, Saito K. CREB3L2-mediated expression of Sec23A/Sec24D is involved in hepatic stellate cell activation through ER-Golgi transport. Sci Rep. 2017;7:7992 pubmed publisher
    ..We observed significant isoform-specific upregulation of the inner coat protein complex II (COPII) components, Sec23A and Sec24D, via the transmembrane bZIP transcription factor, CREB3L2/BBF2H7, during HSC activation...
  36. Otsu W, Kurooka T, Otsuka Y, Sato K, Inaba M. A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C. J Biol Chem. 2013;288:18521-32 pubmed publisher
    ..A synthetic polypeptide containing the N terminus of bovine AE1 bound the Sec23A-Sec24C complex through a selective interaction with Sec24C...
  37. Mancias J, Goldberg J. Structural basis of cargo membrane protein discrimination by the human COPII coat machinery. EMBO J. 2008;27:2918-28 pubmed publisher
  38. Pagano A, Letourneur F, Garcia Estefania D, Carpentier J, Orci L, Paccaud J. Sec24 proteins and sorting at the endoplasmic reticulum. J Biol Chem. 1999;274:7833-40 pubmed
    ..Together, our data suggest that in addition to its role in the shaping up of the vesicle, the Sec23-24p complex may be implicated in cargo selection and concentration. ..