SEB

Summary

Gene Symbol: SEB
Description: SET binding protein 1
Alias: MRD29, SEB, SET-binding protein
Species: human
Products:     SEB

Top Publications

  1. Minakuchi M, Kakazu N, Gorrin Rivas M, Abe T, Copeland T, Ueda K, et al. Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET. Eur J Biochem. 2001;268:1340-51 pubmed
    ..This new protein, which we name SEB (SET-binding protein), is identified as a 170-kDa protein by immunoprecipitation with a specific antibody and is ..
  2. Ott M, Schmidt M, Schwarzwaelder K, Stein S, Siler U, Koehl U, et al. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med. 2006;12:401-9 pubmed
  3. Pardanani A, Lasho T, Laborde R, Elliott M, Hanson C, Knudson R, et al. CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia. Leukemia. 2013;27:1870-3 pubmed publisher
    ..Four CSF3RT618I-mutated cases co-expressed SETBP1 mutations. We conclude that CSF3RT618I is a highly sensitive and specific molecular marker for CNL and should be incorporated into current diagnostic criteria. ..
  4. Hoischen A, van Bon B, Gilissen C, Arts P, van Lier B, Steehouwer M, et al. De novo mutations of SETBP1 cause Schinzel-Giedion syndrome. Nat Genet. 2010;42:483-5 pubmed publisher
    ..We also identified SETBP1 mutations in eight additional cases using Sanger sequencing. All mutations clustered to a highly conserved 11-bp exonic region, suggesting a dominant-negative or gain-of-function effect. ..
  5. Piazza R, Valletta S, Winkelmann N, Redaelli S, Spinelli R, Pirola A, et al. Recurrent SETBP1 mutations in atypical chronic myeloid leukemia. Nat Genet. 2013;45:18-24 pubmed publisher
    ..In summary, mutated SETBP1 represents a newly discovered oncogene present in aCML and closely related diseases. ..
  6. Kawamoto Y, Ueno Y, Nakahashi E, Obayashi M, Sugihara K, Qiao S, et al. Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation. J Nutr Biochem. 2016;27:112-22 pubmed publisher
    ..In addition, 6-gingerol suppressed both superantigen staphylococcal enterotoxin B (SEB)- and anti-CD3-induced T cell proliferation...
  7. Blomqvist S, Leonhardt Ã, Arirachakaran P, Carlén A, Dahlén G. Phenotype, genotype, and antibiotic susceptibility of Swedish and Thai oral isolates of Staphylococcus aureus. J Oral Microbiol. 2015;7:26250 pubmed publisher
    ..and for the presence of the virulence genes: hlg, clfA, can, sdrC, sdrD, sdrE, map/eap (adhesins) and sea, seb, sec, tst, eta, etb, pvl (toxins)...
  8. Akindolire M, Babalola O, Ateba C. Detection of Antibiotic Resistant Staphylococcus aureus from Milk: A Public Health Implication. Int J Environ Res Public Health. 2015;12:10254-75 pubmed publisher
    ..aureus. In addition, 32.7% of isolates possessed the sec gene whereas the sea, seb sed, see, cna, eta, etb genes were not detected...
  9. Wlodarski M, Collin M, Horwitz M. GATA2 deficiency and related myeloid neoplasms. Semin Hematol. 2017;54:81-86 pubmed publisher
    ..The high risk for progression to advanced myeloid neoplasia and life-threatening infectious complications guide decision-making towards timely stem cell transplantation. ..

More Information

Publications131 found, 100 shown here

  1. Kraushaar B, Ballhausen B, Leeser D, Tenhagen B, Käsbohrer A, Fetsch A. Antimicrobial resistances and virulence markers in Methicillin-resistant Staphylococcus aureus from broiler and turkey: A molecular view from farm to fork. Vet Microbiol. 2017;200:25-32 pubmed publisher
    ..One Non-CC398 strain isolated from turkey meat was found positive for the seb gene and also enterotoxin production...
  2. Hao D, Xing X, Li G, Wang X, Zhang M, Zhang W, et al. Prevalence, toxin gene profiles, and antimicrobial resistance of Staphylococcus aureus isolated from quick-frozen dumplings. J Food Prot. 2015;78:218-23 pubmed publisher
    ..The predominant toxin gene was sec (38.5%), followed by seg (19.7%), sej (16.2%), see (12.8%), sea (11.1%), and seb (10.3%), whereas eta, etb, and tsst-1 genes were not detected. These findings indicate that S...
  3. Liang Y, Tu C, Tan C, El Sayed Ahmed M, Dai M, Xia Y, et al. Antimicrobial resistance, virulence genes profiling and molecular relatedness of methicillin-resistant Staphylococcus aureus strains isolated from hospitalized patients in Guangdong Province, China. Infect Drug Resist. 2019;12:447-459 pubmed publisher
    ..4%) and lnuA (18.44%). Profiling of virulence genes revealed the following: sea (11.7%), seb (21.4%), sec (0.97%), sed (0.97%), hla (86.41%), hlb (17.48%), hlg (10...
  4. Casaes Nunes R, Pires de Souza C, Pereira K, Del Aguila E, Flosi Paschoalin V. Identification and molecular phylogeny of coagulase-negative staphylococci isolates from Minas Frescal cheese in southeastern Brazil: Superantigenic toxin production and antibiotic resistance. J Dairy Sci. 2016;99:2641-2653 pubmed publisher
    ..All CNS strains carried multiple enterotoxin genes, with high incidence of sea and seb (90 and 70%, respectively), followed by sec/see, seh/sei, and sed with intermediate incidence (60, 50, and 40%, ..
  5. Hon K, Tsang K, Kung J, Leung T, Lam C, Wong C. Clinical Signs, Staphylococcus and Atopic Eczema-Related Seromarkers. Molecules. 2017;22: pubmed publisher
    ..Concentrations of anti-staphylococcus enterotoxin A and B immunoglobulin E (anti-SEA and anti-SEB), selected Treg/Th/APC chemokines, skin hydration and transepidermal water loss (TEWL) were measured in these ..
  6. Peter J, Frey O, Stallmach A, Bruns T. Attenuated antigen-specific T cell responses in cirrhosis are accompanied by elevated serum interleukin-10 levels and down-regulation of HLA-DR on monocytes. BMC Gastroenterol. 2013;13:37 pubmed publisher
    ..were quantified after T cell-stimulation with the viral peptides EBNA1 and BZLF1 or the bacterial superantigen SEB by flow cytometry. Serum levels of lipopolysaccharide-binding protein (LBP) and IL-10 were quantified by ELISA...
  7. Minai Fleminger Y, Gangwar R, Migalovich Sheikhet H, Seaf M, Leibovici V, Hollander N, et al. The CD48 receptor mediates Staphylococcus aureus human and murine eosinophil activation. Clin Exp Allergy. 2014;44:1335-46 pubmed publisher
    ..eosinophils (BMEos) in their interaction with heat-killed SA and its three exotoxins, Staphylococcal enterotoxin B (SEB), protein A (PtA) and peptidoglycan (PGN)...
  8. Lee H, Kim J, Kim H, Jekarl D, Kim Y, Yu J, et al. Clonal spread of catalase-negative ST5/SCCmec II Staphylococcus aureus carrying the staphylococcal enterotoxin A (sea), staphylococcal enterotoxin b (seb), and toxic shock toxin (tst) virulence genes. Ann Clin Lab Sci. 2014;44:394-8 pubmed
    ..17 isolates harbored toxic shock toxin (tst), staphylococcal enterotoxin A (sea), and staphylococcal enterotoxin B (seb) virulence genes. The mortality rate of the present study was 11...
  9. Lambert C, Cubedo J, Padro T, Vilahur G, López Bernal S, Rocha M, et al. Effects of a Carob-Pod-Derived Sweetener on Glucose Metabolism. Nutrients. 2018;10: pubmed publisher
    ..beverage, obtained from natural carbohydrates containing pinitol (PEB) compared to a sucrose-enriched beverage (SEB) in the context of impaired glucose tolerance (IGT) and diabetes...
  10. Zhou Z, Zhang M, Li H, Yang H, Li X, Song X, et al. Prevalence and molecular characterization of Staphylococcus aureus isolated from goats in Chongqing, China. BMC Vet Res. 2017;13:352 pubmed publisher
    ..Enterotoxin genes were found in 53.13% of the strains. Of which, sej was the most prevalent (21.88%), followed by seb, sec, and see with the same level (18.75%). The most prevalent combination were seb?+?see and seb?+?tst...
  11. Aguilar J, Varshney A, Pechuan X, Dutta K, Nosanchuk J, Fries B. Monoclonal antibodies protect from Staphylococcal Enterotoxin K (SEK) induced toxic shock and sepsis by USA300 Staphylococcus aureus. Virulence. 2017;8:741-750 pubmed publisher
    ..Neutralization of superantigens, including SEB and TSST-1, has proven to be protective in several animal models of toxic shock and sepsis...
  12. Costa F, Belo N, Costa E, Andrade G, Pereira L, Carvalho I, et al. Frequency of enterotoxins, toxic shock syndrome toxin-1, and biofilm formation genes in Staphylococcus aureus isolates from cows with mastitis in the Northeast of Brazil. Trop Anim Health Prod. 2018;50:1089-1097 pubmed publisher
    ..aureus isolates, from which 25 (65.78%) carried toxin genes, including seb, sec, sed, tst, and icaD adhesion gene. These S. aureus isolates belong to 21 ribotypes and three S...
  13. Bonsaglia E, Silva N, Rossi B, Camargo C, Dantas S, Langoni H, et al. Molecular epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) isolated from milk of cows with subclinical mastitis. Microb Pathog. 2018;124:130-135 pubmed publisher
    ..gel electrophoresis (PFGE), agr cluster (I, II, III and IV) typing, PCR for genes including enterotoxins (sea, seb, sec, sed, see, seg, seh, sei), toxic shock syndrome toxin (tsst-1), and Panton-Valentine leucocidin (pvl), as well ..
  14. Schlievert P, Cahill M, Hostager B, Brosnahan A, Klingelhutz A, Gourronc F, et al. Staphylococcal Superantigens Stimulate Epithelial Cells through CD40 To Produce Chemokines. MBio. 2019;10: pubmed publisher
    ..TSST-1 was better able to stimulate chemokine (IL-8 and MIP-3α) production by HVECs than SEB and SEC, suggesting this is the reason for TSST-1's exclusive association with menstrual TSS...
  15. Sharma V, Sharma S, Dahiya D, Khan A, Mathur M, Sharma A. Coagulase gene polymorphism, enterotoxigenecity, biofilm production, and antibiotic resistance in Staphylococcus aureus isolated from bovine raw milk in North West India. Ann Clin Microbiol Antimicrob. 2017;16:65 pubmed publisher
    ..Of the isolates, 30% were positive for sec, 10% for sea, and 3.3% for seb; these genes are responsible for enterotoxin production, whereas all isolates were found positive for icaAD and eno...
  16. de Souza C, Fortaleza C, Witzel C, Silveira M, Bonesso M, Marques S, et al. Toxigenic profile of methicillin-sensitive and resistant Staphylococcus aureus isolated from special groups. Ann Clin Microbiol Antimicrob. 2016;15:9 pubmed publisher
    ..PCR was used for the detection of the mecA gene, enterotoxin genes (sea, seb, and sec), exfoliative toxins A and B (eta and etb), toxic shock syndrome toxin 1 (tst), panton-valentine ..
  17. de Wit J, Totté J, van Buchem F, Pasmans S. The prevalence of antibody responses against Staphylococcus aureus antigens in patients with atopic dermatitis: a systematic review and meta-analysis. Br J Dermatol. 2017;: pubmed publisher
    ..37, 95% CI 2.93-23.92) and SEB (OR 9.34, 95% CI 3.54-24.93) compared to controls...
  18. Krakauer T. Sulfasalazine attenuates staphylococcal enterotoxin B-induced immune responses. Toxins (Basel). 2015;7:553-9 pubmed publisher
    Staphylococcal enterotoxin B (SEB) and related exotoxins are important virulence factors produced by Staphylococcus aureus as they cause human diseases such as food poisoning and toxic shock...
  19. Li G, Wu C, Wang X, Meng J. Prevalence and characterization of methicillin susceptible Staphylococcus aureus ST398 isolates from retail foods. Int J Food Microbiol. 2015;196:94-7 pubmed publisher
    ..For virulence genes, hld (73.3%), seb and sed (each 66.7%), hla (60.0%), lukPV (33.3%), sej (26.7%), lukED and seg (each 3.3%) were detected...
  20. Martins K, Faccioli P, Bonesso M, Fernandes S, Oliveira A, Dantas A, et al. Characteristics of resistance and virulence factors in different species of coagulase-negative staphylococci isolated from milk of healthy sheep and animals with subclinical mastitis. J Dairy Sci. 2017;100:2184-2195 pubmed publisher
    ..DNA was extracted to detect the presence of the mecA gene, biofilm (icaADBC, bap, and bhp) and toxin genes (sea, seb, sec, sed, tst, and luk-PV) by PCR...
  21. Wu X, Wu W, Zhou Y, Wang X, Li J, Yu Y. Coexisting of bone marrow fibrosis, dysplasia and an X chromosomal abnormality in chronic neutrophilic leukemia with CSF3R mutation: a case report and literature review. BMC Cancer. 2018;18:343 pubmed publisher
    ..In clinical course, the CNL concurrently with severe bone marrow fibrosis and dysplastic features as well as X chromosomal abnormality may predict a worsening prognosis regardless of SETBP1 mutation status. ..
  22. Sadeghi J, Alizadeh N, Ahangar Oskouei M, Laghusi D, Savadi Oskouei D, Nikanfar M, et al. Frequency of superantigen encoding genes of Staphylococcus aureus isolates collected from multiple sclerosis (MS) patients and nasal carriers. Microb Pathog. 2019;127:316-319 pubmed publisher
    ..95%. The most commonly detected superantigens were SEA (31.5%), SEB (17.7%) and ETA (16.9%)...
  23. Chen Z, Pan W, Xian W, Cheng H, Zheng J, Hu Q, et al. Identification of Infantile Diarrhea Caused by Breast Milk-Transmitted Staphylococcus aureus Infection. Curr Microbiol. 2016;73:498-502 pubmed publisher
    ..Among the strains, seb, sec, and tst genes were found, and all were negative for pvl gene. The homology of the S...
  24. Obaidat M, Salman A, Lafi S. Prevalence of Staphylococcus aureus in Imported Fish and Correlations between Antibiotic Resistance and Enterotoxigenicity. J Food Prot. 2015;78:1999-2005 pubmed publisher
    ..The isolates were tested for mecA gene, antibiotic resistance, and enterotoxin genes (sea, seb, sec, sed, see, seg, seh, and sei)...
  25. Badr G, Mahmoud M, Farhat K, Waly H, Al Abdin O, Rabah D. Maternal supplementation of diabetic mice with thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and free radical production and restoring lymphocyte proliferation via PI3K/AKT signaling. Lipids Health Dis. 2013;12:37 pubmed publisher
    ..4 and -7), an obvious reduction in the number of circulating lymphocytes, decreased proliferation of superantigen (SEB)-stimulated lymphocytes and aberrant AKT phosphorylation...
  26. Monistero V, Graber H, Pollera C, Cremonesi P, Castiglioni B, Bottini E, et al. Staphylococcus aureus Isolates from Bovine Mastitis in Eight Countries: Genotypes, Detection of Genes Encoding Different Toxins and Other Virulence Genes. Toxins (Basel). 2018;10: pubmed publisher
    ..The etb, seb and see genes were not detected in any of the isolates, while only two isolates were MRSA (Germany and ..
  27. de Oliveira Titz T, Orfali R, de Lollo C, Dos Santos V, da Silva Duarte A, Sato M, et al. Impaired CD23 and CD62L expression and tissue inhibitors of metalloproteinases secretion by eosinophils in adults with atopic dermatitis. J Eur Acad Dermatol Venereol. 2016;30:2072-2076 pubmed publisher
    ..We aimed to evaluate the phenotype and functional response of eosinophils under staphylococcal enterotoxin B (SEB) and Toll-like receptor (TLR)-2/6 (FSL-1) stimulation in the secretion of CCL5, MMPs and TIMPs in adults with AD...
  28. Sallam K, Abd Elghany S, Elhadidy M, Tamura T. Molecular Characterization and Antimicrobial Resistance Profile of Methicillin-Resistant Staphylococcus aureus in Retail Chicken. J Food Prot. 2015;78:1879-84 pubmed publisher
    ..Furthermore, genes encoding α-hemolysin (hla) and staphylococcal enterotoxins (sea, seb, and sec) were detected in all of the 288 MRSA isolates...
  29. Mun S, Kong R, Seo Y, Zhou T, Kang O, Shin D, et al. Subinhibitory concentrations of punicalagin reduces expression of virulence-related exoproteins by Staphylococcus aureus. FEMS Microbiol Lett. 2016;363: pubmed
    ..9, graded subinhibitory concentrations of punicalagin reduced the production of ?-toxin, SEA and SEB in methicillin-resistant Staphylococcus aureus in a dose-dependent manner...
  30. Bleier B, Singleton A, Nocera A, Kocharyan A, Petkova V, Han X. P-glycoprotein regulates Staphylococcus aureus enterotoxin B-stimulated interleukin-5 and thymic stromal lymphopoietin secretion in organotypic mucosal explants. Int Forum Allergy Rhinol. 2016;6:169-77 pubmed publisher
    ..from patients with CRS (n = 10) and CRSwNP (n = 10) and stimulated with Staphylococcus aureus enterotoxin B (SEB). P-gp was inhibited using zosuquidar trihydrochloride (herein Zosuquidar)...
  31. Chen B, Dai X, He B, Pan K, Li H, Liu X, et al. Differences in Staphylococcus aureus nasal carriage and molecular characteristics among community residents and healthcare workers at Sun Yat-Sen University, Guangzhou, Southern China. BMC Infect Dis. 2015;15:303 pubmed publisher
    ..5% of isolates carried both the Staphylococcus aureus enterotoxin A (sea) and enterotoxin B (seb) genes. These data indicate a low prevalence of nasal MRSA carriage but evidence of molecular heterogeneity among S...
  32. Wang D, Zhang L, Yong C, Shen M, Ali T, Shahid M, et al. Relationships among superantigen toxin gene profiles, genotypes, and pathogenic characteristics of Staphylococcus aureus isolates from bovine mastitis. J Dairy Sci. 2017;100:4276-4286 pubmed publisher
    ..0% each), followed by seo, tst, and etB (28.0% each), etA (24.0%), sem and sep (16.0% each), seb, sec, sed, and sek (12.0% each), and sea and seh genes (8.0% each); the seg, sej, and ser genes were present in 4...
  33. Rola J, Korpysa Dzirba W, Czubkowska A, Osek J. Prevalence of enterotoxin genes and antimicrobial resistance of coagulase-positive staphylococci recovered from raw cow milk. J Dairy Sci. 2015;98:4273-8 pubmed publisher
    ..staphylococcal enterotoxin markers were sed, sej, and ser, whereas none of the analyzed isolates possessed the seb and see genes. Almost one-half of the tested strains (43%) were resistant to one or more antimicrobial agents...
  34. Xie X, Bao Y, Ouyang N, Dai X, Pan K, Chen B, et al. Molecular epidemiology and characteristic of virulence gene of community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus isolates in Sun Yat-sen Memorial hospital, Guangzhou, Southern China. BMC Infect Dis. 2016;16:339 pubmed publisher
    ..Notably, seb gene was only detected in CA-MRSA isolates (52.2 %), likely a significant marker for CA-MRSA isolates...
  35. Khemiri M, Akrout Alhusain A, Abbassi M, El Ghaieb H, Santos Costa S, Belas A, et al. Clonal spread of methicillin-resistant Staphylococcus aureus-t6065-CC5-SCCmecV-agrII in a Libyan hospital. J Glob Antimicrob Resist. 2017;10:101-105 pubmed publisher
    ..All isolates were PVL negative; however, exfoliative-encoding genes (eta: 25) and enterotxin genes (seb: 32, seo: 32, sei: 32, ser: 32, seu: 32, seg: 32, sej: 32, sed: 31, sen: 29, seh: 26, sec: 26, sea: 6, sek: 5), ..
  36. Xu S, Kasper K, Zeppa J, McCormick J. Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization. Toxins (Basel). 2015;7:1821-36 pubmed publisher
    ..S. aureus COL produces relatively high levels of staphylococcal enterotoxin B (SEB), and colonization with wild-type S. aureus COL resulted in clear Vβ8-specific T cell skewing responses. S...
  37. Rasooly R, Bruck H, Balsam J, Prickril B, Ossandon M, Rasooly A. Improving the Sensitivity and Functionality of Mobile Webcam-Based Fluorescence Detectors for Point-of-Care Diagnostics in Global Health. Diagnostics (Basel). 2016;6: pubmed publisher
    ..Botulinum A neurotoxin, Shiga toxin, and S. aureus enterotoxin B (SEB), and flow cytometry has been used to detect very low cell concentrations...
  38. Devang Divakar D, Muzaheed -, Aldeyab S, Alfawaz S, Alkheraif A, Ahmed Khan A. High proportions of Staphylococcus epidermidis in dental caries harbor multiple classes of antibiotics resistance, significantly increase inflammatory interleukins in dental pulps. Microb Pathog. 2017;109:29-34 pubmed publisher
    ..These isolates also showed the presence of mecA gene and another virulence gene i. e sea and seb comparatively more than healthy individual isolates...
  39. Farzin M, Molls M, Astner S, Rondak I, Oechsner M. Simultaneous integrated vs. sequential boost in VMAT radiotherapy of high-grade gliomas. Strahlenther Onkol. 2015;191:945-52 pubmed publisher
    ..sequential boost (SEB)...
  40. Dao K, Tyner J. What's different about atypical CML and chronic neutrophilic leukemia?. Hematology Am Soc Hematol Educ Program. 2015;2015:264-71 pubmed publisher
  41. Patnaik M, Lasho T, Vijayvargiya P, Finke C, Hanson C, Ketterling R, et al. Prognostic interaction between ASXL1 and TET2 mutations in chronic myelomonocytic leukemia. Blood Cancer J. 2016;6:e385 pubmed publisher
    ..3). We confirm the negative prognostic impact imparted by ASXL1 mutations and suggest a favorable impact from TET2 mutations in the absence of ASXL1 mutations. ..
  42. Wang X, Gao S, Yan X, Li Q, Zhang J, Long Y, et al. Giant spontaneous exchange bias obtained by tuning magnetic compensation in samarium ferrite single crystals. Phys Chem Chem Phys. 2018;20:3687-3693 pubmed publisher
    Spontaneous exchange bias (SEB) under zero field cooling (ZFC) has recently attracted lots of attention due to its underlying physics and potential applications...
  43. Elliott M, Pardanani A, Hanson C, Lasho T, Finke C, Belachew A, et al. ASXL1 mutations are frequent and prognostically detrimental in CSF3R-mutated chronic neutrophilic leukemia. Am J Hematol. 2015;90:653-6 pubmed publisher
    ..The study also suggests pathogenetic roles for SETBP1 and ASXL1 mutations in disease evolution into blast phase disease and CMML, respectively. ..
  44. Imani Fooladi A, Halabian R, Mahdavi M, Amin M, Mahmoodzadeh Hosseini H. Staphylococcal enterotoxin B/texosomes as a candidate for breast cancer immunotherapy. Tumour Biol. 2016;37:739-48 pubmed publisher
    A new recombinant construct made up of two components, texosomes (TEX) and staphylococcal enterotoxin B (SEB), showed cytostatic properties against several types of tumor cells in vitro...
  45. Maxson J, Tyner J. Genomics of chronic neutrophilic leukemia. Blood. 2017;129:715-722 pubmed publisher
    ..Understanding the complete landscape and chronology of genomic events in CNL will help in the development of improved therapeutic strategies for this patient population. ..
  46. Sihto H, Stephan R, Engl C, Chen J, Johler S. Effect of food-related stress conditions and loss of agr and sigB on seb promoter activity in S. aureus. Food Microbiol. 2017;65:205-212 pubmed publisher
    Staphylococcal enterotoxin B (SEB) causes staphylococcal food poisoning and is produced in up to ten times higher quantities than other major enterotoxins...
  47. Riva A, Borghi E, Cirasola D, Colmegna S, Borgo F, Amato E, et al. Methicillin-Resistant Staphylococcus aureus in Raw Milk: Prevalence, SCCmec Typing, Enterotoxin Characterization, and Antimicrobial Resistance Patterns. J Food Prot. 2015;78:1142-6 pubmed publisher
    ..on their antimicrobial susceptibility patterns and the presence of genes encoding staphylococcal enterotoxins (sea, seb, sec, sed, and see). About half (45.7%) of the strains were enterotoxigenic, and 37...
  48. Demir D, Karabay O, Guven M, Kayabasoglu G, Yılmaz M. Do Staphylococcus aureus superantigens play a role in the pathogenesis of otitis media with effusion in children?. Int J Pediatr Otorhinolaryngol. 2016;84:71-4 pubmed publisher
    ..All samples were processed for bacterial culture and detection of five staphylococcal SEs (SEA, SEB, SEC and SED) and toxic shock syndrome toxin-1 using the Rapid Latex Agglutination Test...
  49. Guo J, Xiang Y, Huang H, Peng Y, Wei Y, Lan Y. [Distribution characteristics of rs1891385A/C and rs10975519C/T polymorphisms of interleukin-33 gene in Guangxi population]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:964-8 pubmed
    ..of IL-33 gene in 283 subjects from Guangxi Zhuang Autonomous Region were analyzed with single base extension (PCR-SEB) and DNA sequencing to analyze the differences in their distribution frequencies between genders and between Zhuang ..
  50. Turhan A, Onrust S, ten Klooster P, Pieterse M. A school-based programme for tobacco and alcohol prevention in special education: effectiveness of the modified 'healthy school and drugs' intervention and moderation by school subtype. Addiction. 2017;112:533-543 pubmed publisher
    ..SE for adolescents with intellectual/physical disabilities (SEI; n = 13), behavioural/emotional difficulties (SEB; n = 136) and learning disabilities/developmental disorders (SEL; n = 214)...
  51. Azimirad M, Dezfulian A, Alebouyeh M, Bahreiny Esfehani R, Shahrokh S, Zali M. Infection with enterotoxigenic Staphylococcus aureus as a concern in patients with gastroenteritis. J Glob Antimicrob Resist. 2017;9:111-114 pubmed publisher
    ..PCR amplification of enterotoxin genes (sea, seb, sec, sed and see) was carried out on all S...
  52. Okano M, Fujiwara T, Kariya S, Higaki T, Makihara S, Haruna T, et al. Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps. Allergol Int. 2016;65:96-102 pubmed publisher
    ..with or without Poly(IC), and were then cultured in the presence or absence of staphylococcal enterotoxin B (SEB), following which the levels of IL-5, IL-10, IL-13, IL-17A and interferon (IFN)-γ in the supernatant were ..
  53. Yao X, Zhou J, Yang J, Zhang W, Ma J, Wen X, et al. SETBP1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome. Pathol Res Pract. 2018;214:706-712 pubmed publisher
    ..We established a rapid, inexpensive, high-throughput and sensitive method to screen SETBP1 mutations. SETBP1 mutations were a rare molecular event in AML and MDS patients. ..
  54. Shi C, Zhao X, Li W, Meng R, Liu Z, Liu M, et al. Inhibitory effect of totarol on exotoxin proteins hemolysin and enterotoxins secreted by Staphylococcus aureus. World J Microbiol Biotechnol. 2015;31:1565-73 pubmed publisher
    ..pathogenicity, the exotoxins α-hemolysin, staphylococcal enterotoxin A (SEA) and staphylococcal enterotoxin B (SEB) are thought to be of major significance...
  55. Khalmuratova R, Lee M, Kim D, Park J, Shin H. Induction of nasal polyps using house dust mite and Staphylococcal enterotoxin B in C57BL/6 mice. Allergol Immunopathol (Madr). 2016;44:66-75 pubmed publisher
    The murine polyp model was developed previously using ovalbumin and Staphylococcus aureus enterotoxin B (SEB)...
  56. Bice Urbach B, Kratochwill T. Teleconsultation: The use of technology to improve evidence-based practices in rural communities. J Sch Psychol. 2016;56:27-43 pubmed publisher
    ..method of service delivery to support teachers who are struggling to address student social-emotional behavioral (SEB) concerns. Despite its benefits, a number of barriers (e.g...
  57. Anvari S, Grimbergen A, Davis C, Makedonas G. Protein transport inhibitors downregulate the expression of LAG-3 on regulatory T cells. J Immunol Methods. 2017;447:47-51 pubmed publisher
    ..We stimulated human PBMCs with either PMA/ionomycin or Staphylococcal Enterotoxin B (SEB) and analyzed CD4+CD25+FoxP3+ Tregs for LAG-3 expression in concert with other Treg phenotypic markers...
  58. He J, Guo X, Liu Z, Yang P, Yang S. Vitamin D inhibits the Staphylococcal enterotoxin B-induced expression of tumor necrosis factor in microglial cells. Immunol Res. 2017;65:913-919 pubmed publisher
    ..Vitamin D (VitD3) deficiency is associated with the pathogenesis of inflammation. Staphylococcal enterotoxin B (SEB) is a superantigen and can initiate inflammation...
  59. Stevens M, Stephan R, Johler S. Complete and Assembled Genome Sequence of Staphylococcus aureus RKI4, a Food-Poisoning Strain Exhibiting a Novel S. aureus Pathogenicity Island Carrying seb. Genome Announc. 2015;3: pubmed publisher
    ..Hierarchical assembly of the genome resulted in a 2,725,654-bp chromosome and a 17,905-bp mobile genetic element. ..
  60. Vishwakarma B, Nguyen N, Makishima H, Hosono N, Gudmundsson K, Negi V, et al. Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development. Leukemia. 2016;30:200-8 pubmed publisher
  61. Whitfield S, Taylor C, Risdall J, Griffiths G, Jones J, Williamson E, et al. Interference of the T Cell and Antigen-Presenting Cell Costimulatory Pathway Using CTLA4-Ig (Abatacept) Prevents Staphylococcal Enterotoxin B Pathology. J Immunol. 2017;198:3989-3998 pubmed publisher
    Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds the receptors in the APC/T cell synapse and causes increased proliferation of T cells and a cytokine storm syndrome in vivo...
  62. Makishima H, Yoshida K, Nguyen N, Przychodzen B, Sanada M, Okuno Y, et al. Somatic SETBP1 mutations in myeloid malignancies. Nat Genet. 2013;45:942-6 pubmed publisher
    ..Somatic mutations of SETBP1 seem to cause gain of function, are associated with myeloid leukemic transformation and convey poor prognosis in myelodysplastic syndromes (MDS) and CMML. ..
  63. Chao G, Bao G, Cao Y, Yan W, Wang Y, Zhang X, et al. Prevalence and diversity of enterotoxin genes with genetic background of Staphylococcus aureus isolates from different origins in China. Int J Food Microbiol. 2015;211:142-7 pubmed publisher
    ..Seven genes, sea, seb, seg, seo, sem, seq, and sel were more frequently detected...
  64. Alakortes J, Kovaniemi S, Carter A, Bloigu R, Moilanen I, Ebeling H. Do child healthcare professionals and parents recognize social-emotional and behavioral problems in 1-year-old infants?. Eur Child Adolesc Psychiatry. 2017;26:481-495 pubmed publisher
    Growing evidence supports the existence of clinically significant social-emotional/behavioral (SEB) problems among as young as 1-year-old infants...
  65. Ouyang Y, Qiao C, Chen Y, Zhang S. Clinical significance of CSF3R, SRSF2 and SETBP1 mutations in chronic neutrophilic leukemia and chronic myelomonocytic leukemia. Oncotarget. 2017;8:20834-20841 pubmed publisher
    ..In conclusion, our study highlights effective diagnostic and prognostic markers of CNL and CMML patients in the Chinese population. ..
  66. Xu C, He X, Liu W, Chen Y, Zhou C, Duan Z, et al. An inhibitor peptide of toll-like receptor 2 shows therapeutic potential for allergic conjunctivitis. Int Immunopharmacol. 2017;46:9-15 pubmed publisher
    ..Here, a designed small peptide ZY12 was found to contain therapeutic potential in staphylococcal enterotoxin B (SEB)-induced AC model...
  67. Toyosawa Y, Ikeo M, Taneda D, Okino S. Quantitative analysis of adsorption and desorption behavior of individual cellulase components during the hydrolysis of lignocellulosic biomass with the addition of lysozyme. Bioresour Technol. 2017;234:150-157 pubmed publisher
    ..on/from substrates during the hydrolysis of microcrystalline cellulose and steam exploded sugarcane bagasse (SEB) were investigated...
  68. Cavicchioli V, Scatamburlo T, Yamazi A, Pieri F, Nero L. Occurrence of Salmonella, Listeria monocytogenes, and enterotoxigenic Staphylococcus in goat milk from small and medium-sized farms located in Minas Gerais State, Brazil. J Dairy Sci. 2015;98:8386-90 pubmed publisher
    ..were selected (CPS=26; CNS=25) and tested by PCR for the presence of classic enterotoxin-encoding genes (sea, seb, sec, sed, and see)...
  69. Rauch A, Wieczorek D, Graf E, Wieland T, Endele S, Schwarzmayr T, et al. Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study. Lancet. 2012;380:1674-82 pubmed publisher
    ..German Ministry of Education and Research, European Commission 7th Framework Program, and Swiss National Science Foundation. ..
  70. Makishima H. Somatic SETBP1 mutations in myeloid neoplasms. Int J Hematol. 2017;105:732-742 pubmed publisher
    ..SETBP1 is a major oncogene in myeloid neoplasms, which cooperates with various genetic events and causes distinct phenotypes of MDS/MPN and sAML. ..
  71. Zheng Y, Weng Q. High spatial- and temporal-resolution anthropogenic heat discharge estimation in Los Angeles County, California. J Environ Manage. 2018;206:1274-1286 pubmed publisher
    ..vehicle exhausts, and human metabolism releases, is an important component in the urban Surface Energy Balance (SEB) system, and is key to understanding of many urban environmental issues...
  72. Hüsecken Y, Muche S, Kustermann M, Klingspor M, Palmer A, Braumüller S, et al. MDSCs are induced after experimental blunt chest trauma and subsequently alter antigen-specific T cell responses. Sci Rep. 2017;7:12808 pubmed publisher
    ..MDSCs also prevented antigen-induced T cell expansion in vivo, since staphylococcus enterotoxin B (SEB)-induced proliferation of v?8+ T cells was impaired in TxT mice in the presence of CD11b+Gr-1<..
  73. Marseglia G, Scordo M, Pescucci C, Nannetti G, Biagini E, Scandurra V, et al. 372 kb microdeletion in 18q12.3 causing SETBP1 haploinsufficiency associated with mild mental retardation and expressive speech impairment. Eur J Med Genet. 2012;55:216-21 pubmed publisher
    ..The critical deleted region contains SETBP1 gene (SET binding protein 1)...
  74. Mciver Z, Kryman M, Choi Y, Coe B, Schamerhorn G, Linder M, et al. Selective photodepletion of malignant T cells in extracorporeal photopheresis with selenorhodamine photosensitizers. Bioorg Med Chem. 2016;24:3918-3931 pubmed publisher
    ..To determine the selectivity of the photosensitizers in the ECP milieu, staphylococcal enterotoxin B (SEB)-stimulated and non-stimulated human lymphocytes were combined with HUT-78 cells (a CTCL) to simulate ECP...
  75. Acuna Hidalgo R, Deriziotis P, Steehouwer M, Gilissen C, Graham S, van Dam S, et al. Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies. PLoS Genet. 2017;13:e1006683 pubmed publisher
    ..Drawing on previous studies of somatic SETBP1 mutations in leukemia, our results reveal a genotype-phenotype correlation in germline SETBP1 mutations spanning a molecular, cellular and clinical phenotype. ..
  76. Kettler R, Feeney Kettler K, Dembitzer L. Social, emotional, and behavioral screening: A comparison of two measures and two methods across informants. J Sch Psychol. 2017;64:93-108 pubmed publisher
    The current study is a correlational design comparing a multiple-gate social, emotional, and behavioral (SEB) screening system with a single-gate SEB screening system using a common criterion variable...
  77. Laborde R, Patnaik M, Lasho T, Finke C, Hanson C, Knudson R, et al. SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML. Leukemia. 2013;27:2100-2 pubmed publisher
  78. Hou H, Kuo Y, Tang J, Chou W, Yao M, Lai Y, et al. Clinical implications of the SETBP1 mutation in patients with primary myelodysplastic syndrome and its stability during disease progression. Am J Hematol. 2014;89:181-6 pubmed publisher
    Mutations of the SET binding protein 1 (SETBP1) gene have been identified in patients with myeloid neoplasms, but the clinical relevance of this mutation and its association with other gene mutations in myelodysplastic syndrome (MDS) and ..
  79. Inoue D, Kitaura J, Matsui H, Hou H, Chou W, Nagamachi A, et al. SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS. Leukemia. 2015;29:847-57 pubmed publisher
    ..These data reveal that SETBP1-MT are critical drivers of ASXL1-mutated MDS and identify several deregulated pathways as potential therapeutic targets in high-risk MDS. ..
  80. Stieglitz E, Troup C, Gelston L, Haliburton J, Chow E, Yu K, et al. Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia. Blood. 2015;125:516-24 pubmed publisher
    ..Five-year event-free survival in patients with SETBP1 mutations was 18% ± 9% compared with 51% ± 8% for those without mutations (P = .006). ..
  81. Shou L, Cao D, Dong X, Fang Q, Wu Y, Zhang Y, et al. Prognostic significance of SETBP1 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia, and chronic neutrophilic leukemia: A meta-analysis. PLoS ONE. 2017;12:e0171608 pubmed publisher
    This meta-analysis investigates the prognostic effect of SET binding protein 1 (SETBP1) mutations in patients with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML), or chronic neutrophilic leukemia (CNL)...
  82. Zhang H, Xie L, Liu X, Xiong M, Cao L, Li Y. The reversal of the spontaneous exchange bias effect and zero-field-cooling magnetization in La1.5Sr0.5Co1-xFexMnO6: the effect of Fe doping. Phys Chem Chem Phys. 2017;19:25186-25196 pubmed publisher
    ..the reversal of both zero-field-cooling magnetization and the sign switching of the spontaneous exchange bias (SEB) with the doping concentration from magnetic measurements...
  83. Ding R, Gao W, He Z, Wu F, Chu Y, Wu J, et al. Circulating CD4+CXCR5+ T cells contribute to proinflammatory responses in multiple ways in coronary artery disease. Int Immunopharmacol. 2017;52:318-323 pubmed publisher
    ..CD4+CXCR5+PD-1- T cells significantly upregulated PD-1 following anti-CD3/CD28 or SEB stimulation...
  84. Wang W, Baloch Z, Jiang T, Zhang C, Peng Z, Li F, et al. Enterotoxigenicity and Antimicrobial Resistance of Staphylococcus aureus Isolated from Retail Food in China. Front Microbiol. 2017;8:2256 pubmed publisher
    ..4%). A total of 29.7% S. aureus isolates harbored the classical SEs genes (sea, seb, sec, and sed). The sea and seb genes were the most frequent SEs genes detected...
  85. McKay D, Botelho F, Ceponis P, Richards C. Superantigen immune stimulation activates epithelial STAT-1 and PI 3-K: PI 3-K regulation of permeability. Am J Physiol Gastrointest Liver Physiol. 2000;279:G1094-103 pubmed
    ..necrosis factor-alpha (10 ng/ml)] and conditioned medium from superantigen [Staphylococcus aureus enterotoxin B (SEB)]-activated peripheral blood mononuclear cells (PBMC) using electrophoretic mobility shift assays (EMSA)...
  86. Gonzalez A, Marques L, Gomes M, Beltrão J, Pinheiro M, Esper L, et al. Methicillin resistant Staphylococcus aureus in minas frescal cheese: evaluation of classic enterotoxin genes, antimicrobial resistance and clonal diversity. FEMS Microbiol Lett. 2017;: pubmed publisher
    ..Seven (22.6%) S. aureus carried mecA gene and two of them carried enterotoxin genes seb/sec and sea/seb. Five (16.1%) S...
  87. Wakabayashi Y, Umeda K, Yonogi S, Nakamura H, Yamamoto K, Kumeda Y, et al. Staphylococcal food poisoning caused by Staphylococcus argenteus harboring staphylococcal enterotoxin genes. Int J Food Microbiol. 2018;265:23-29 pubmed publisher
    ..Several enterotoxin genes (seb, seg, sei, sem, sen, seo, and selu2) were found in their genome and the production of SEB was confirmed by reverse ..
  88. Linder K, Iragavarapu C, Liu D. SETBP1 mutations as a biomarker for myelodysplasia /myeloproliferative neoplasm overlap syndrome. Biomark Res. 2017;5:33 pubmed publisher
    ..In this review, we summarized the latest data on the role of SETBP1 mutations in the overlap syndrome. SETBP1 mutations may serve as a biomarker for the diagnosis and poor prognosis of the overlap syndrome...
  89. Goehler L, Gaykema R, Hansen M, Kleiner J, Maier S, Watkins L. Staphylococcal enterotoxin B induces fever, brain c-Fos expression, and serum corticosterone in rats. Am J Physiol Regul Integr Comp Physiol. 2001;280:R1434-9 pubmed
    ..In mice, T cell-dependent immune stimuli, including the bacterial superantigen staphylococcal enterotoxin B (SEB), can activate the PVH...
  90. Filges I, Shimojima K, Okamoto N, Röthlisberger B, Weber P, Huber A, et al. Reduced expression by SETBP1 haploinsufficiency causes developmental and expressive language delay indicating a phenotype distinct from Schinzel-Giedion syndrome. J Med Genet. 2011;48:117-22 pubmed publisher
    Mutations of the SET binding protein 1 gene (SETBP1) on 18q12.3 have recently been reported to cause Schinzel-Giedion syndrome (SGS)...
  91. Meggendorfer M, Bacher U, Alpermann T, Haferlach C, Kern W, Gambacorti Passerini C, et al. SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations. Leukemia. 2013;27:1852-60 pubmed publisher
    ..001 for both) and were mutually exclusive of JAK2 and TET2 mutations. In conclusion, SETBP1mut add an important new diagnostic marker for MDS/MPN and in particular for aCML. ..
  92. Visconte V, Tabarroki A, Zhang L, Hasrouni E, Gerace C, Frum R, et al. Clinicopathologic and molecular characterization of myeloid neoplasms harboring isochromosome 17(q10). Am J Hematol. 2014;89:862 pubmed publisher