Gene Symbol: SDR16C5
Description: short chain dehydrogenase/reductase family 16C member 5
Alias: EPHD-2, RDH#2, RDH-E2, RDHE2, retSDR2, epidermal retinol dehydrogenase 2, epidermal retinal dehydrogenase 2, retinal short chain dehydrogenase reductase, retinal short-chain dehydrogenase reductase 2
Species: human
Products:     SDR16C5

Top Publications

  1. Belyaeva O, Chang C, Berlett M, Kedishvili N. Evolutionary origins of retinoid active short-chain dehydrogenases/reductases of SDR16C family. Chem Biol Interact. 2015;234:135-43 pubmed publisher containing retinoid active enzymes, which are retinol dehydrogenase 10 (RDH10), retinol dehydrogenases E2 (RDHE2) and RDHE2-similar, and dehydrogenase reductase (SDR family) member 3 (DHRS3)...
  2. Lundová T, Zemanová L, Malčeková B, Skarka A, Štambergová H, Havránková J, et al. Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3). Chem Biol Interact. 2015;234:178-87 pubmed publisher
    ..Expression of DHRS3 was shown at the level of both mRNA and protein in the human liver, testis and small intestine. This new information could open other areas of DHRS3 protein research. ..
  3. Xiong X, Yang H, Yang B, Chen C, Huang L. Identification of quantitative trait transcripts for growth traits in the large scales of liver and muscle samples. Physiol Genomics. 2015;47:274-80 pubmed publisher
    ..Through an integrative genomic approach, we identified SDR16C5 as the important candidate gene in pig growth trait...
  4. Martí Solans J, Belyaeva O, Torres Aguila N, Kedishvili N, Albalat R, Canestro C. Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate. Mol Biol Evol. 2016;33:2401-16 pubmed publisher
    ..Thus, the survival and extensive duplication of Cco and RdhE2 in O...
  5. Wu B, Chen Y, Chen Y, Fan J, Rohrer B, Crouch R, et al. Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. Invest Ophthalmol Vis Sci. 2002;43:3365-72 pubmed
    ..RDH10 is a novel retinol oxidase expressed in the RPE. This enzyme can generate all-trans retinal from all-trans retinol and may play an important role in the photic visual cycle. ..
  6. Matsuzaka Y, Okamoto K, Yoshikawa Y, Takaki A, Oka A, Mabuchi T, et al. hRDH-E2 gene polymorphisms, variable transcriptional start sites, and psoriasis. Mamm Genome. 2004;15:668-75 pubmed
    ..On this basis, we conclude that the polymorphisms that we detected for the hRDH-E2 gene do not contribute to the etiology of psoriasis but may be important in diseases of other tissues. ..
  7. Markova N, Pinkas Sarafova A, Simon M. A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity. J Invest Dermatol. 2006;126:2019-31 pubmed
    ..These findings add hRoDH-E2 to the small group of metabolic enzymes, which, by being recruited over promoter regions, could directly link the cytoplasmic and nuclear functions within the cell. ..
  8. Lettre G, Jackson A, Gieger C, Schumacher F, Berndt S, Sanna S, et al. Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet. 2008;40:584-91 pubmed publisher
    ..These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait. ..
  9. Lee S, Belyaeva O, Kedishvili N. Biochemical characterization of human epidermal retinol dehydrogenase 2. Chem Biol Interact. 2009;178:182-7 pubmed publisher
    The mRNA encoding a putative human enzyme named Epidermal Retinol Dehydrogenase 2 (RDH-E2) was found to be significantly elevated in psoriatic skin [Y. Matsuzaka, K. Okamoto, H. Tsuji, T. Mabuchi, A. Ozawa, G. Tamiya, H...

More Information


  1. Takahashi Y, Moiseyev G, Farjo K, Ma J. Characterization of key residues and membrane association domains in retinol dehydrogenase 10. Biochem J. 2009;419:113-22, 1 p following 122 pubmed publisher
    ..These studies identified the key residues for the activity of RDH10 and will contribute to the further elucidation of mechanism of this important enzyme. ..
  2. Matsuzaka Y, Okamoto K, Tsuji H, Mabuchi T, Ozawa A, Tamiya G, et al. Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion. Biochem Biophys Res Commun. 2002;297:1171-80 pubmed
    ..So, this gene was designated as hRDH-E2 (human epidermal retinal dehydrogenase 2). The hRDH-E2 gene has a single functional copy on chromosome 8q12...
  3. Adams M, Lee S, Belyaeva O, Wu L, Kedishvili N. Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10. Chem Biol Interact. 2017;276:88-94 pubmed publisher
    ..The predicted protein products of these genes, retinol dehydrogenase epidermal 2 (RDHE2, SDR16C5) and retinol dehydrogenase epidermal 2-similar (RDHE2S, SDR16C6), share 59% and 56% sequence similarity with ..