SDHB

Summary

Gene Symbol: SDHB
Description: succinate dehydrogenase complex iron sulfur subunit B
Alias: CWS2, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, iron-sulfur subunit of complex II, succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Species: human
Products:     SDHB

Top Publications

  1. Meyer Rochow G, Smith J, Richardson A, Marsh D, Sidhu S, Robinson B, et al. Denaturing high performance liquid chromatography detection of SDHB, SDHD, and VHL germline mutations in pheochromocytoma. J Surg Res. 2009;157:55-62 pubmed publisher
    ..Type 1, and the pheochromocytoma/paraganglioma syndromes caused by mutations in the RET, VHL, NF1, SDHB, and SDHD genes, respectively...
  2. Baysal B, Willett Brozick J, Lawrence E, Drovdlic C, Savul S, McLeod D, et al. Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas. J Med Genet. 2002;39:178-83 pubmed
    ..Germline mutations in the mitochondrial complex II genes, SDHB, SDHC, and SDHD, cause hereditary paraganglioma (PGL)...
  3. Schimke R, Collins D, Stolle C. Paraganglioma, neuroblastoma, and a SDHB mutation: Resolution of a 30-year-old mystery. Am J Med Genet A. 2010;152A:1531-5 pubmed publisher
    ..family members with late onset disease have come to our attention, and molecular study revealed a mutation in the SDHB gene...
  4. Miettinen M, Wang Z, Sarlomo Rikala M, Osuch C, Rutkowski P, Lasota J. Succinate dehydrogenase-deficient GISTs: a clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age. Am J Surg Pathol. 2011;35:1712-21 pubmed publisher
    ..GISTs were identified in this study on the basis of immunohistochemical loss of succinate dehydrogenase subunit B (SDHB), which signals functional loss of the SDH complex...
  5. Vanharanta S, Buchta M, McWhinney S, Virta S, Peczkowska M, Morrison C, et al. Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. Am J Hum Genet. 2004;74:153-9 pubmed
    Hereditary paraganglioma syndrome has recently been shown to be caused by germline heterozygous mutations in three (SDHB, SDHC, and SDHD) of the four genes that encode mitochondrial succinate dehydrogenase...
  6. Doyle L, Nelson D, Heinrich M, Corless C, Hornick J. Loss of succinate dehydrogenase subunit B (SDHB) expression is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours: a comprehensive genotype-phenotype correlation study. Histopathology. 2012;61:801-9 pubmed publisher
    ..Recent studies have suggested that these tumours can be identified by loss of succinate dehydrogenase subunit B (SDHB) expression...
  7. Brière J, Favier J, El Ghouzzi V, Djouadi F, Benit P, Gimenez A, et al. Succinate dehydrogenase deficiency in human. Cell Mol Life Sci. 2005;62:2317-24 pubmed
    Mitochondrial succinate dehydrogenase (SDH) consists merely of four nuclearly encoded subunits. It participates in the electron transfer in the respiratory chain and in succinate catabolism in the Krebs cycle...
  8. Cascon A, Montero Conde C, Ruiz Llorente S, Mercadillo F, Leton R, Rodriguez Antona C, et al. Gross SDHB deletions in patients with paraganglioma detected by multiplex PCR: a possible hot spot?. Genes Chromosomes Cancer. 2006;45:213-9 pubmed
    ..purpose, we used a technique that is easy to implement in the lab to specifically detect gross deletions affecting SDHB, SDHC, and SDHD...
  9. Janeway K, Kim S, Lodish M, Nose V, Rustin P, Gaal J, et al. Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations. Proc Natl Acad Sci U S A. 2011;108:314-8 pubmed publisher
    ..WT GISTs lacking demonstrable SDH genetic inactivation were evaluated for SDHB expression by immunohistochemistry and Western blotting and for complex II activity...
  10. Cascon A, Pita G, Burnichon N, Landa I, López Jiménez E, Montero Conde C, et al. Genetics of pheochromocytoma and paraganglioma in Spanish patients. J Clin Endocrinol Metab. 2009;94:1701-5 pubmed publisher
    ..Two hundred thirty-seven nonrelated probands were analyzed for the major susceptibility genes: VHL, RET, SDHB, SDHC, and SDHD...

Detail Information

Publications78

  1. Meyer Rochow G, Smith J, Richardson A, Marsh D, Sidhu S, Robinson B, et al. Denaturing high performance liquid chromatography detection of SDHB, SDHD, and VHL germline mutations in pheochromocytoma. J Surg Res. 2009;157:55-62 pubmed publisher
    ..Type 1, and the pheochromocytoma/paraganglioma syndromes caused by mutations in the RET, VHL, NF1, SDHB, and SDHD genes, respectively...
  2. Baysal B, Willett Brozick J, Lawrence E, Drovdlic C, Savul S, McLeod D, et al. Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas. J Med Genet. 2002;39:178-83 pubmed
    ..Germline mutations in the mitochondrial complex II genes, SDHB, SDHC, and SDHD, cause hereditary paraganglioma (PGL)...
  3. Schimke R, Collins D, Stolle C. Paraganglioma, neuroblastoma, and a SDHB mutation: Resolution of a 30-year-old mystery. Am J Med Genet A. 2010;152A:1531-5 pubmed publisher
    ..family members with late onset disease have come to our attention, and molecular study revealed a mutation in the SDHB gene...
  4. Miettinen M, Wang Z, Sarlomo Rikala M, Osuch C, Rutkowski P, Lasota J. Succinate dehydrogenase-deficient GISTs: a clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age. Am J Surg Pathol. 2011;35:1712-21 pubmed publisher
    ..GISTs were identified in this study on the basis of immunohistochemical loss of succinate dehydrogenase subunit B (SDHB), which signals functional loss of the SDH complex...
  5. Vanharanta S, Buchta M, McWhinney S, Virta S, Peczkowska M, Morrison C, et al. Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. Am J Hum Genet. 2004;74:153-9 pubmed
    Hereditary paraganglioma syndrome has recently been shown to be caused by germline heterozygous mutations in three (SDHB, SDHC, and SDHD) of the four genes that encode mitochondrial succinate dehydrogenase...
  6. Doyle L, Nelson D, Heinrich M, Corless C, Hornick J. Loss of succinate dehydrogenase subunit B (SDHB) expression is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours: a comprehensive genotype-phenotype correlation study. Histopathology. 2012;61:801-9 pubmed publisher
    ..Recent studies have suggested that these tumours can be identified by loss of succinate dehydrogenase subunit B (SDHB) expression...
  7. Brière J, Favier J, El Ghouzzi V, Djouadi F, Benit P, Gimenez A, et al. Succinate dehydrogenase deficiency in human. Cell Mol Life Sci. 2005;62:2317-24 pubmed
    Mitochondrial succinate dehydrogenase (SDH) consists merely of four nuclearly encoded subunits. It participates in the electron transfer in the respiratory chain and in succinate catabolism in the Krebs cycle...
  8. Cascon A, Montero Conde C, Ruiz Llorente S, Mercadillo F, Leton R, Rodriguez Antona C, et al. Gross SDHB deletions in patients with paraganglioma detected by multiplex PCR: a possible hot spot?. Genes Chromosomes Cancer. 2006;45:213-9 pubmed
    ..purpose, we used a technique that is easy to implement in the lab to specifically detect gross deletions affecting SDHB, SDHC, and SDHD...
  9. Janeway K, Kim S, Lodish M, Nose V, Rustin P, Gaal J, et al. Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations. Proc Natl Acad Sci U S A. 2011;108:314-8 pubmed publisher
    ..WT GISTs lacking demonstrable SDH genetic inactivation were evaluated for SDHB expression by immunohistochemistry and Western blotting and for complex II activity...
  10. Cascon A, Pita G, Burnichon N, Landa I, López Jiménez E, Montero Conde C, et al. Genetics of pheochromocytoma and paraganglioma in Spanish patients. J Clin Endocrinol Metab. 2009;94:1701-5 pubmed publisher
    ..Two hundred thirty-seven nonrelated probands were analyzed for the major susceptibility genes: VHL, RET, SDHB, SDHC, and SDHD...
  11. Solis D, Burnichon N, Timmers H, Raygada M, Kozupa A, Merino M, et al. Penetrance and clinical consequences of a gross SDHB deletion in a large family. Clin Genet. 2009;75:354-63 pubmed publisher
    Mutations in the gene encoding subunit B of the mitochondrial enzyme succinate dehydrogenase (SDHB) are inherited in an autosomal dominant manner and are associated with hereditary paraganglioma (PGL) and pheochromocytoma...
  12. Pasini B, McWhinney S, Bei T, Matyakhina L, Stergiopoulos S, Muchow M, et al. Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD. Eur J Hum Genet. 2008;16:79-88 pubmed
    ..unrelated families), the GISTs were caused by germline mutations of the genes encoding subunits B, C, or D (the SDHB, SDHC and SDHD genes, respectively)...
  13. Benn D, Croxson M, Tucker K, Bambach C, Richardson A, Delbridge L, et al. Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas. Oncogene. 2003;22:1358-64 pubmed
    ..In addition to mutations in RET and VHL in familial disease, germline mutations in SDHD and SDHB genes that encode subunits of mitochondrial complex II have also been associated with the development of familial ..
  14. Neumann H, Bausch B, McWhinney S, Bender B, Gimm O, Franke G, et al. Germ-line mutations in nonsyndromic pheochromocytoma. N Engl J Med. 2002;346:1459-66 pubmed
    ..the newly identified genes for succinate dehydrogenase subunit D (SDHD) and succinate dehydrogenase subunit B (SDHB), which predispose carriers to pheochromocytomas and glomus tumors...
  15. Muth A, Abel F, Jansson S, Nilsson O, Ahlman H, Wängberg B. Prevalence of germline mutations in patients with pheochromocytoma or abdominal paraganglioma and sporadic presentation: a population-based study in Western Sweden. World J Surg. 2012;36:1389-94 pubmed publisher
    Germline mutations in the susceptibility genes RET, SDHB, SDHD, and VHL have been reported in 7.5-24% of patients with pheochromocytoma (Pheo) or paraganglioma (PGL) and sporadic presentation...
  16. Amar L, Baudin E, Burnichon N, Peyrard S, Silvera S, Bertherat J, et al. Succinate dehydrogenase B gene mutations predict survival in patients with malignant pheochromocytomas or paragangliomas. J Clin Endocrinol Metab. 2007;92:3822-8 pubmed
    ..to analyze survival according to clinical characteristics at diagnosis of malignancy and the presence or absence of SDHB mutations. This was a retrospective cohort study. A total of 54 patients with malignant tumors were included...
  17. Mannelli M, Castellano M, Schiavi F, Filetti S, Giacchè M, Mori L, et al. Clinically guided genetic screening in a large cohort of italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomas. J Clin Endocrinol Metab. 2009;94:1541-7 pubmed publisher
    ..Germ-line mutations in known susceptibility genes were investigated by gene sequencing (VHL, RET, SDHB, SDHC, SDHD) or diagnosed according to phenotype (NF1)...
  18. Astuti D, Latif F, Dallol A, Dahia P, Douglas F, George E, et al. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet. 2001;69:49-54 pubmed
    ..components of succinate dehydrogenase, SDHC and SDHD, anchor the gene products of two other components, SDHA and SDHB, which form the catalytic core, to the inner-mitochondrial membrane...
  19. Bayley J, Grimbergen A, van Bunderen P, van der Wielen M, Kunst H, Lenders J, et al. The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patients. BMC Med Genet. 2009;10:34 pubmed publisher
    Germline mutations of the tumor suppressor genes SDHB, SDHC and SDHD play a major role in hereditary paraganglioma and pheochromocytoma...
  20. Zhang D, Wang W, Xiang B, Li N, Huang S, Zhou W, et al. Reduced succinate dehydrogenase B expression is associated with growth and de-differentiation of colorectal cancer cells. Tumour Biol. 2013;34:2337-47 pubmed publisher
    Succinate dehydrogenases (SDH), including SDHA, SDHB, SDHC, and SDHD, form the respiratory complex II in the mitochondria and play an important role in cell growth and homeostasis...
  21. Cervera A, Bayley J, Devilee P, McCreath K. Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells. Mol Cancer. 2009;8:89 pubmed publisher
    ..ChIP analysis revealed that the core promoter of IGFBP7, which encodes a secreted protein upregulated after loss of SDHB, showed decreased occupancy by H3K27me3 in the absence of SDH...
  22. Cascon A, Cebrian A, Ruiz Llorente S, Telleria D, Benitez J, Robledo M. SDHB mutation analysis in familial and sporadic phaeochromocytoma identifies a novel mutation. J Med Genet. 2002;39:E64 pubmed
  23. Brouwers F, Eisenhofer G, Tao J, Kant J, Adams K, Linehan W, et al. High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic testing. J Clin Endocrinol Metab. 2006;91:4505-9 pubmed
    ..Mutations of the gene for succinate dehydrogenase subunit B (SDHB) are associated with a high risk of malignancy, but establishing the precise contribution requires relatively large ..
  24. Korpershoek E, Van Nederveen F, Dannenberg H, Petri B, Komminoth P, Perren A, et al. Genetic analyses of apparently sporadic pheochromocytomas: the Rotterdam experience. Ann N Y Acad Sci. 2006;1073:138-48 pubmed
    ..Mutation analysis was performed for RET (56 cases), VHL (136 cases), and SDHD (126 cases) and SDHB (47 cases). No germline RET mutations, six (4.4%) germline VHL mutations, two (1...
  25. Ricketts C, Woodward E, Killick P, Morris M, Astuti D, Latif F, et al. Germline SDHB mutations and familial renal cell carcinoma. J Natl Cancer Inst. 2008;100:1260-2 pubmed publisher
    ..We investigated whether germline mutations in fumarate hydratase (FH) or succinate dehydrogenase subunit genes (SDHB, SDHC, SDHD) were associated with RCC susceptibility in 68 patients with no clinical evidence of an RCC ..
  26. Au H, Ream Robinson D, Bellew L, Broomfield P, Saghbini M, Scheffler I. Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase. Gene. 1995;159:249-53 pubmed
    The iron-sulfur protein (Ip) subunit of succinate dehydrogenase (SDH and complex II) of the respiratory chain is highly conserved in evolution [Gould et al., Proc. Natl. Acad. Sci. USA 86 (1989) 1934-1938]...
  27. Ricketts C, Forman J, Rattenberry E, Bradshaw N, Lalloo F, Izatt L, et al. Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD. Hum Mutat. 2010;31:41-51 pubmed publisher
    Succinate dehydrogenase B (SDHB) and D (SDHD) subunit gene mutations predispose to adrenal and extraadrenal pheochromocytomas, head and neck paragangliomas (HNPGL), and other tumor types...
  28. Gaal J, Stratakis C, Carney J, Ball E, Korpershoek E, Lodish M, et al. SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors. Mod Pathol. 2011;24:147-51 pubmed publisher
    Mutations in the tumor suppressor genes SDHB, SDHC, and SDHD (or collectively SDHx) cause the inherited paraganglioma syndromes, characterized by pheochromocytomas and paragangliomas...
  29. Pigny P, Cardot Bauters C, Do Cao C, Vantyghem M, Carnaille B, Pattou F, et al. Should genetic testing be performed in each patient with sporadic pheochromocytoma at presentation?. Eur J Endocrinol. 2009;160:227-31 pubmed publisher
    ..A germline mutation in one of the five susceptibility genes (VHL, RET, SDHD, SDHC, SDHB) was identified in eight patients (8%) with an age of onset between 13 and 57 years...
  30. Guzy R, Sharma B, Bell E, Chandel N, Schumacker P. Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol. 2008;28:718-31 pubmed
    Mitochondrial complex II is a tumor suppressor comprised of four subunits (SdhA, SdhB, SdhC, and SdhD)...
  31. Neumann H, Pawlu C, Peczkowska M, Bausch B, McWhinney S, Muresan M, et al. Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. JAMA. 2004;292:943-51 pubmed
    Germline mutations of the genes encoding succinate dehydrogenase subunits B (SDHB) and D (SDHD) predispose to paraganglioma syndromes type 4 (PGL-4) and type 1 (PGL-1), respectively...
  32. Martin T, Irving R, Maher E. The genetics of paragangliomas: a review. Clin Otolaryngol. 2007;32:7-11 pubmed
    ..susceptibility to head and neck paragangliomas: succinate dehydrogenase complex subunit 'D', 'B' and 'C' (SDHD, SDHB and SDHC). The genes most frequently implicated: SDHD and SDHB, also predispose to phaeochromocytoma...
  33. Cervera A, Apostolova N, Crespo F, Mata M, McCreath K. Cells silenced for SDHB expression display characteristic features of the tumor phenotype. Cancer Res. 2008;68:4058-67 pubmed publisher
    ..In particular, mutations in the nuclear-encoded subunits of succinate dehydrogenase (SDHB, SDHC, and SDHD) cause paragangliomas and pheochromocytomas...
  34. Cascon A, Landa I, López Jiménez E, Díez Hernández A, Buchta M, Montero Conde C, et al. Molecular characterisation of a common SDHB deletion in paraganglioma patients. J Med Genet. 2008;45:233-8 pubmed
    ..Recently, we found two unrelated Spanish families carrying the previously reported SDHB exon 1 deletion, and suggested that this chromosomal region could be a hotspot deletion area...
  35. Gill A, Benn D, Chou A, Clarkson A, Muljono A, Meyer Rochow G, et al. Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes. Hum Pathol. 2010;41:805-14 pubmed publisher
    ..with germline RET, Von Hippel-Lindau (VHL), neurofibromatosis type I (NF1), and succinate dehydrogenase subunits (SDHB, SDHC, and SDHD) mutations...
  36. Bayley J, van Minderhout I, Weiss M, Jansen J, Oomen P, Menko F, et al. Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma. BMC Med Genet. 2006;7:1 pubmed
    Germline mutations of the SDHD, SDHB and SDHC genes, encoding three of the four subunits of succinate dehydrogenase, are a major cause of hereditary paraganglioma and pheochromocytoma, and demonstrate that these genes are classic tumor ..
  37. Ngeow J, Mester J, Rybicki L, Ni Y, Milas M, Eng C. Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations. J Clin Endocrinol Metab. 2011;96:E2063-71 pubmed publisher
    ..Children presenting with thyroid cancer should be tested for PTEN mutations. ..
  38. Amar L, Bertherat J, Baudin E, Ajzenberg C, Bressac de Paillerets B, Chabre O, et al. Genetic testing in pheochromocytoma or functional paraganglioma. J Clin Oncol. 2005;23:8812-8 pubmed
    ..Clinical data and blood samples were collected, and all five major pheo-pgl susceptibility genes (RET, VHL, SDHB, SDHD, and SDHC) were screened. Neurofibromatosis type 1 was diagnosed from phenotypic criteria...
  39. Young A, Baysal B, Deb A, Young W. Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene. J Clin Endocrinol Metab. 2002;87:4101-5 pubmed
    ..However, a missense point mutation was detected in the SDHB gene: c.725G-->A in exon 7, which alters a conserved arginine at amino acid position 242 to a histidine (R242H)...
  40. Ni Y, Zbuk K, Sadler T, Patocs A, Lobo G, Edelman E, et al. Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes. Am J Hum Genet. 2008;83:261-8 pubmed publisher
    ..Germline mutations in succinate dehydrogenase subunits SDHB-D cause pheochromocytoma-paraganglioma syndrome...
  41. Gill A, Chou A, Vilain R, Clarkson A, Lui M, JIN R, et al. Immunohistochemistry for SDHB divides gastrointestinal stromal tumors (GISTs) into 2 distinct types. Am J Surg Pathol. 2010;34:636-44 pubmed publisher
    ..We postulated that these GISTs would show negative staining for succinate dehydrogenase B (SDHB)...
  42. Timmers H, Kozupa A, Eisenhofer G, Raygada M, Adams K, Solis D, et al. Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas. J Clin Endocrinol Metab. 2007;92:779-86 pubmed
    Mutations of the gene encoding succinate dehydrogenase subunit B (SDHB) predispose to malignant paraganglioma (PGL). Recognition of the SDHB phenotype in apparently sporadic PGL directs appropriate treatment and family screening...
  43. Castro Vega L, Kiando S, Burnichon N, Buffet A, Amar L, Simian C, et al. The MITF, p.E318K Variant, as a Risk Factor for Pheochromocytoma and Paraganglioma. J Clin Endocrinol Metab. 2016;101:4764-4768 pubmed
    ..005). Noteworthy, two patients were homozygous for the p.E318K risk allele, a patient with metastatic PCC and an SDHB-mutated patient with PGL. Our results indicate that the germline variant MITF, p...
  44. Urbina Fuentes M, Jasso Gutiérrez L, Schiavon Ermani R, Lozano R, FINKELMAN J. [Transition from Millennium Development Goals to Sustainable Development Goals from the perspective of the social determinants of health and health equity]. Gac Med Mex. 2017;153:697-730 pubmed publisher
    ..world with great social and economic inequalities, from the perspective of the social determinants of health (SDH), the relevance of the new 17 sustainable development goals (SDGs) is greater...
  45. Tanweer O, Frisoli F, Bravate C, Harrison G, Pacione D, Kondziolka D, et al. Tranexamic Acid for Treatment of Residual Subdural Hematoma After Bedside Twist-Drill Evacuation. World Neurosurg. 2016;91:29-33 pubmed publisher
    ..Most SDHs were mixed density. Mean SDH volume on presentation was 145.96 ± 40.22 cm(3) with a mean midline shift of 9.44 ± 4.84 mm...
  46. Chen S, Jia N, Ding M, Yuan Y. Comparative analysis of L-sorbose dehydrogenase by docking strategy for 2-keto-L-gulonic acid production in Ketogulonicigenium vulgare and Bacillus endophyticus consortium. J Ind Microbiol Biotechnol. 2016;43:1507-1516 pubmed
    ..we try to increase the 2-KGA productivity by computer-aided selection of genes encoding L-sorbose dehydrogenases (SDH) of Ketogulonicigenium vulgare...
  47. Wang X, Zhou P, Sun X, Wei G, Zhang L, Wang H, et al. Modification of the hTERT promoter by heat shock elements enhances the efficiency and specificity of cancer targeted gene therapy. Int J Hyperthermia. 2016;32:244-53 pubmed publisher
    ..Luciferase reporters were constructed by inserting eight HSEs and the hTERT promoter (8HSEs-hTERTp) upstream of the pGL4.20 vector luciferase gene...
  48. Peters E, Offringa C, Kos D, van der Laarse W, Jaspers R. Regulation of myoglobin in hypertrophied rat cardiomyocytes in experimental pulmonary hypertension. Pflugers Arch. 2016;468:1697-707 pubmed publisher
    ..Succinate dehydrogenase (SDH) activity was unaltered, indicating that oxidative capacity per cell increased...
  49. Cui Z, Gao C, Li J, Hou J, Lin C, Qi Q. Engineering of unconventional yeast Yarrowia lipolytica for efficient succinic acid production from glycerol at low pH. Metab Eng. 2017;42:126-133 pubmed publisher
    ..CoA-transfer reaction from acetyl-CoA to succinate in mitochondria rather than pyruvate decarboxylation reaction in SDH negative Y. lipolytica...
  50. Tamayo M, Besoaín Á, Rebolledo J. [Social determinants of health and disability: updating the model for determination]. Gac Sanit. 2018;32:96-100 pubmed publisher
    Social determinants of health (SDH) are conditions in which people live. These conditions impact their lives, health status and social inclusion level...
  51. Tian X, He W, Yang R, Liu Y. Dl-3-n-butylphthalide protects the heart against ischemic injury and H9c2 cardiomyoblasts against oxidative stress: involvement of mitochondrial function and biogenesis. J Biomed Sci. 2017;24:38 pubmed publisher
    ..enzymes in MI, and restored heart mitochondrial enzymes (isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH), and a-ketoglutarate dehydrogenase (a-KGDH) activities after MI...
  52. Cheshire E, Malcomson R, Sun P, Mirkes E, Amoroso J, Rutty G. A systematic autopsy survey of human infant bridging veins. Int J Legal Med. 2018;132:449-461 pubmed publisher
    In the first years of life, subdural haemorrhage (SDH) within the cranial cavity can occur through accidental and non-accidental mechanisms as well as from birth-related injury...
  53. Parente M, Forte E, Falabella M, Boneca I, Teixeira M, Giuffrè A, et al. Nitrosative stress defences of the enterohepatic pathogenic bacterium Helicobacter pullorum. Sci Rep. 2017;7:9909 pubmed publisher
    ..Here several protein candidates of H. pullorum, namely a truncated (TrHb) and a single domain haemoglobin (SdHb), and three peroxiredoxin-like proteins (Prx1, Prx2 and Prx3) were investigated...
  54. Nagler R, Bigman C, Ramanadhan S, Ramamurthi D, Viswanath K. Prevalence and Framing of Health Disparities in Local Print News: Implications for Multilevel Interventions to Address Cancer Inequalities. Cancer Epidemiol Biomarkers Prev. 2016;25:603-12 pubmed publisher
    Americans remain under-informed about cancer and other health disparities and the social determinants of health (SDH)...
  55. Asan Z. Growth Potential of Subdural Hematomas Under Clinical Observation: Which Subdural Hematomas Tend to Grow and Why They Do. World Neurosurg. 2018;: pubmed publisher
    To study the prognoses of patients with subdural hematoma (SDH) who were not operated on at the time of the first diagnosis and the causes of enlarged hematomas in some patients during the follow-up period...
  56. Valle A. The Mexican experience in monitoring and evaluation of public policies addressing social determinants of health. Glob Health Action. 2016;9:29030 pubmed publisher
    ..of Health (CSDH) called for interventions and policies aimed at tackling the social determinants of health (SDH)...
  57. Brenca M, Rossi S, Polano M, Gasparotto D, Zanatta L, Racanelli D, et al. Transcriptome sequencing identifies ETV6-NTRK3 as a gene fusion involved in GIST. J Pathol. 2016;238:543-9 pubmed publisher
    ..To this end we performed transcriptome sequencing on five KIT/PDGFRA/BRAF-mutation negative, SDH-proficient tumours. Intriguingly, the analysis unveiled the presence of an ETV6-NTRK3 gene fusion...
  58. Bosutti A, Salanova M, Blottner D, Buehlmeier J, Mulder E, Rittweger J, et al. Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days of bed rest. J Appl Physiol (1985). 2016;121:838-848 pubmed publisher
    ..Fiber oxidative capacity was determined as the optical density (OD) at 660 nm of succinate dehydrogenase (SDH)-stained sections...
  59. Gill A. Succinate dehydrogenase (SDH)-deficient neoplasia. Histopathology. 2018;72:106-116 pubmed publisher
    The succinate dehydrogenase (SDH) complex is a key respiratory enzyme composed of four subunits: SDHA, SDHB, SDHC and SDHD...
  60. Cavalcanti de Albuquerque J, de Souza Ferreira E, de Carvalho D, Galina A. Mitochondria-Bound Hexokinase (mt-HK) Activity Differ in Cortical and Hypothalamic Synaptosomes: Differential Role of mt-HK in H2O2 Depuration. Mol Neurobiol. 2017;: pubmed publisher
    ..consumption and ROS production were related to higher mitochondrial complex II activity (succinate dehydrogenase-SDH) in CSy rather than to mitochondrial number...
  61. Panov A, Orynbayeva Z. Determination of mitochondrial metabolic phenotype through investigation of the intrinsic inhibition of succinate dehydrogenase. Anal Biochem. 2017;: pubmed publisher
    ..We provide evidence that for brain and heart mitochondria the intrinsic inhibition of succinate dehydrogenase (SDH) is a key mechanism for attenuation of mitochondrial respiration and energy production in response to the organ's ..
  62. Wu M, Chen N, Huang C, He Y, Zhao Y, Chen X, et al. Effect of Low Temperature on Globin Expression, Respiratory Metabolic Enzyme Activities, and Gill Structure of Litopenaeus vannamei. Biochemistry (Mosc). 2017;82:844-851 pubmed publisher
    ..the activities of respiratory metabolic enzymes including lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH) were measured, and it was found that LDH activity gradually increased while SDH activity decreased after low-..
  63. Chidambaram S, Vijayan R, Sekar S, Mani S, Rajamani B, Ganapathy R. Simultaneous blockade of NMDA receptors and PARP-1 activity synergistically alleviate immunoexcitotoxicity and bioenergetics in 3-nitropropionic acid intoxicated mice: Evidences from memantine and 3-aminobenzamide interventions. Eur J Pharmacol. 2017;803:148-158 pubmed publisher
    ..Striatal succinate dehydrogenase (SDH), ATP and NAD levels (as bioenergetic markers); glutamate, microglial marker (IBA-1), astroglial marker (GFAP), ..
  64. King K, Prodanov T, Kantorovich V, Fojo T, Hewitt J, Zacharin M, et al. Metastatic pheochromocytoma/paraganglioma related to primary tumor development in childhood or adolescence: significant link to SDHB mutations. J Clin Oncol. 2011;29:4137-42 pubmed publisher
    To present data on the high rate of SDHB mutations in patients with metastatic pheochromocytoma/paraganglioma whose initial tumor presentation began in childhood or adolescence...
  65. Aldera A, Govender D. Gene of the month: SDH. J Clin Pathol. 2017;: pubmed publisher
    ..Germline mutations in SDHA are associated with Leigh syndrome. Mutations in SDHB, SDHC and SDHD are found in an increasing number of neoplasms, most notably paragangliomas and ..
  66. Korpershoek E, Petri B, van Nederveen F, Dinjens W, Verhofstad A, de Herder W, et al. Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma. Endocr Relat Cancer. 2007;14:453-62 pubmed
    ..sPGL are caused by germline mutations in RET, von Hippel-Lindau disease (VHL), succinate dehydrogenase subunit B (SDHB), or subunit D SDHD...
  67. Fang Y, Zhong R, Sun X, Zhou D. High salt diet decreases reproductive performance in rams and down-regulates gene expression of some components of the renin-angiotensin system in the testis. Theriogenology. 2017;107:127-133 pubmed publisher
    ..hormone receptors (AR, FSHR, LHR, CYP11A1 and CYP17A1), but there were no significant effects on key enzymes (LDH, SDH, AKP and ATPase) in the testis...
  68. Kalfusová A, Kodet R. [Molecular mechanisms of primary and secondary resistance, molecular-genetic features and characteristics of KIT/PDGFRA non-mutated GISTs]. Cesk Patol. 2017;53:167-173 pubmed
    ..molecular features, for example in mutations in the BRAF, KRAS, NF1 genes or defects of succinate dehydrogenase (SDH) subunits...
  69. Sue M, Martucci V, Frey F, Lenders J, Timmers H, Peczkowska M, et al. Lack of utility of SDHB mutation testing in adrenergic metastatic phaeochromocytoma. Eur J Endocrinol. 2015;172:89-95 pubmed
    Testing for succinate dehydrogenase subunit B (SDHB) mutations is recommended in all patients with metastatic phaeochromocytomas and paragangliomas (PPGLs), but may not be required when metastatic disease is accompanied by adrenaline ..
  70. Pai R, Manipadam M, Singh P, Ebenazer A, Samuel P, Rajaratnam S. Usefulness of Succinate dehydrogenase B (SDHB) immunohistochemistry in guiding mutational screening among patients with pheochromocytoma-paraganglioma syndromes. APMIS. 2014;122:1130-5 pubmed publisher
    ..Recently, Succinate dehydrogenase B (SDHB) immunochemistry has been shown to be an excellent indicator of germline mutations in the SDH genes and could help ..
  71. Dhir M, Li W, Hogg M, Bartlett D, Carty S, McCoy K, et al. Clinical Predictors of Malignancy in Patients with Pheochromocytoma and Paraganglioma. Ann Surg Oncol. 2017;24:3624-3630 pubmed publisher
    ..1), all 11 patients with germline SDHB mutations had malignant disease...
  72. Vest J, Grannis S, Haut D, Halverson P, Menachemi N. Using structured and unstructured data to identify patients' need for services that address the social determinants of health. Int J Med Inform. 2017;107:101-106 pubmed publisher
    ..care providers are adopting population health management approaches that address the social determinants of health (SDH)...
  73. Hadoux J, Favier J, Scoazec J, Leboulleux S, Al Ghuzlan A, Caramella C, et al. SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma. Int J Cancer. 2014;135:2711-20 pubmed publisher
    ..We examined the correlation between Succinate dehydrogenase B (SDHB) mutation and O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression in the ..
  74. Dubova M, Sedivcová M, Michal M, Kokoskova B, Ryska A, Smid D, et al. Utility of immunohistochemical investigation of SDHB and molecular genetic analysis of SDH genes in the differential diagnosis of mesenchymal tumors of GIT. Histol Histopathol. 2015;30:223-32 pubmed publisher
    Loss of expression of beta subunit of succinate dehydrogenase (SDHB) was proved to be present in a subgroup of KIT/PDGFRA wt gastrointestinal stromal tumors (GISTs)...
  75. Han Y, Wang Y, Li L, Xu G, Liu J, Yang K. Bacterial population and chemicals in bioaerosols from indoor environment: Sludge dewatering houses in nine municipal wastewater treatment plants. Sci Total Environ. 2018;618:469-478 pubmed publisher
    ..Sludge dewatering house (SDH) is one of the most serious indoor bioaerosol pollution treatment sectors in MWTPs...
  76. Sieck G, Zhan W, Prakash Y, Daood M, Watchko J. SDH and actomyosin ATPase activities of different fiber types in rat diaphragm muscle. J Appl Physiol (1985). 1995;79:1629-39 pubmed
    ..Succinate dehydrogenase (SDH) and calcium-activated myosin adenosinetriphosphatase (actomyosin ATPase) activities were measured with ..
  77. Montani M, Schmitt A, Schmid S, Locher T, Saremaslani P, Heitz P, et al. No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma. Endocr Relat Cancer. 2005;12:1011-6 pubmed
    Germline mutations of the three succinate dehydrogenase subunits SDHB, SDHC and SDHD have recently been associated with familial pheochromocytoma and paraganglioma...