SDF2L1

Summary

Gene Symbol: SDF2L1
Description: stromal cell-derived factor 2-like 1
Alias: OTTHUMT00000075032, PWP1-interacting protein 8, SDF2-like 1, SDF2-like protein 1, dihydropyrimidinase-like 2, stromal cell-derived factor 2-like protein 1
Species: human

Top Publications

  1. doi SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells
    Akansha Tiwari
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, ON M5G 1L7, Canada
    J Cell Sci 126:1962-8. 2013
  2. doi CNP and DPYSL2 mRNA expression and promoter methylation levels in brain of Alzheimer's disease patients
    Patrícia Natalia Silva
    Disciplina de Genetica, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo, Sao Paulo SP, Brazil
    J Alzheimers Dis 33:349-55. 2013
  3. doi Cynandione A mitigates ischemic injuries in rats with cerebral ischemia
    Rongcai Yue
    School of Pharmacy, Second Military Medical University, Shanghai, China
    J Neurochem 121:451-64. 2012
  4. ncbi Quantitative proteomics analysis of differential protein expression and oxidative modification of specific proteins in the brains of old mice
    H Fai Poon
    Department of Chemistry, Center of Mambrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, USA
    Neurobiol Aging 27:1010-9. 2006
  5. doi Effect by acupuncture on hypothalamic expression of maternally separated rats: proteomic approach
    Hak Jae Kim
    Kohwang Medical Research Institute, Kyung Hee University, Seoul 130 701, Korea
    Neurol Res 32:69-73. 2010
  6. doi Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia
    Daniel Martins-de-Souza
    Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Kraepelinstr 2, 80804 Munich, Germany
    J Psychiatr Res 44:989-91. 2010
  7. doi A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects
    Takayoshi Koide
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Hum Genet 55:469-72. 2010
  8. ncbi [Changes of proteomics in the lung of rats subjected to acrolein inhalation after enalapril administration]
    Yun Hui Zhang
    People s Hospital of Yunnan Province, Kunming 65000, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 41:273-5, 279. 2010
  9. doi Protein biomarkers for in vitro testing of embryotoxicity
    Karlfried Groebe
    ProteoSys AG, Carl Zeiss Str 51, D 55129 Mainz, Germany
    J Proteome Res 9:5727-38. 2010
  10. ncbi Propofol anaesthesia alters the cerebral proteome differently from sevoflurane anaesthesia
    Yoshiaki Tsuboko
    Department of Anaesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    Biomed Res 32:55-65. 2011

Scientific Experts

  • O Carrette
  • Prasad Tongaonkar
  • Shinji Oikawa
  • Daniel Martins-de-Souza
  • Takayoshi Koide
  • Yoshiaki Tsuboko
  • Karin Berg
  • Radhika A Vaishnav
  • H Fai Poon
  • Akansha Tiwari
  • Patrícia Natalia Silva
  • Rongcai Yue
  • Yun Hui Zhang
  • Hak Jae Kim
  • Karlfried Groebe
  • James D Bortner
  • Hua Kang
  • Fransisca Indraswari
  • A Tsolakidou
  • Yi Qiong Zhang
  • Thomas V Getchell
  • D Allan Butterfield
  • Marilyn L Getchell
  • Xinzhi Zhao
  • Christiane Bies
  • Kenji Nakata
  • Spencer Luiz Payão
  • Irmgard Schuiki
  • Michael B Wheeler
  • Jonathan Mill
  • Tatiane Katsue Furuya
  • Lucas Trevizani Rasmussen
  • Paulo Henrique Bertolucci
  • Naguib Mechawar
  • Emma M Allister
  • Liling Zhang
  • Marília Cardoso Smith
  • Ianna Sampaio Braga
  • Elizabeth Suchi Chen
  • Roger Willian de Labio
  • Gustavo Turecki
  • Allen Volchuk
  • Xiaojun Liu
  • Lei Shan
  • S Fukuda
  • Peng Jiang
  • Jigang Zhang
  • Cheng He
  • Xing Yuan
  • Yizhi Yu
  • Weidong Zhang
  • Li Zhang
  • Joo Ho Chung
  • Zhao jun Wang
  • Hae Jeong Park
  • Andrea Seiler
  • Bin Yuan
  • Jeong Yoon Song
  • Shan Zhao
  • Margino Steemans
  • Hyun Kyung Park
  • Martina Klemm-Manns
  • Woijciech Wozny
  • Yun Chao Huang
  • Sung Wook Park
  • Slobodan Poznanovic
  • Jong Soo Yang
  • Mee Sook Hong
  • Dae Jean Jo
  • Annelieke K Peters
  • Gerhard Schwall
  • Hun Kuk Park
  • Chaturvedala Sastri
  • Helmut Zengerling
  • Dong HwanYun
  • Werner Stegmann
  • Sheng Lan Wang
  • Andre Schrattenholz
  • Katrin Hayess
  • Rainer Schopf
  • Horst Spielmann
  • Ju Yeon Ban
  • Petra Jaeckel
  • Tina C Stummann
  • Todd M Umstead
  • Astrid Escudero-Esparza
  • Robert E Mansel
  • Karam El-Bayoumy
  • Elgin Yap
  • Wen G Jiang

Detail Information

Publications24

  1. doi SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells
    Akansha Tiwari
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, ON M5G 1L7, Canada
    J Cell Sci 126:1962-8. 2013
    Stromal cell-derived factor 2-like 1 (SDF2L1) is an endoplasmic reticulum (ER)-localized protein whose function is undefined...
  2. doi CNP and DPYSL2 mRNA expression and promoter methylation levels in brain of Alzheimer's disease patients
    Patrícia Natalia Silva
    Disciplina de Genetica, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo, Sao Paulo SP, Brazil
    J Alzheimers Dis 33:349-55. 2013
    ..No AD-associated differences in CNP and DPYSL2 promoter DNA methylation were observed, suggesting that other mechanisms may be involved in mediating the observed CNP gene expression...
  3. doi Cynandione A mitigates ischemic injuries in rats with cerebral ischemia
    Rongcai Yue
    School of Pharmacy, Second Military Medical University, Shanghai, China
    J Neurochem 121:451-64. 2012
    ..2% reduction in cerebral infarction size at 72 h (p < 0.05 vs. control). Our findings demonstrated that cynandione A mitigated ischemic injuries and should be further explored as a neuroprotective agent for ischemic stroke...
  4. ncbi Quantitative proteomics analysis of differential protein expression and oxidative modification of specific proteins in the brains of old mice
    H Fai Poon
    Department of Chemistry, Center of Mambrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, USA
    Neurobiol Aging 27:1010-9. 2006
    ..Our results establish an initial basis for understanding protein alterations that may lead to age-related cellular dysfunction in the brain...
  5. doi Effect by acupuncture on hypothalamic expression of maternally separated rats: proteomic approach
    Hak Jae Kim
    Kohwang Medical Research Institute, Kyung Hee University, Seoul 130 701, Korea
    Neurol Res 32:69-73. 2010
    ..To identify new proteins on acupuncture effects in maternally separated rats, an animal model for study of early environmental insults, proteomic approach on the expression of the hypothalamic proteins was performed...
  6. doi Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia
    Daniel Martins-de-Souza
    Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Kraepelinstr 2, 80804 Munich, Germany
    J Psychiatr Res 44:989-91. 2010
    ..Our findings not only support previous findings but also indicate areas that warrant further study in schizophrenia...
  7. doi A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects
    Takayoshi Koide
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Hum Genet 55:469-72. 2010
    ..39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects...
  8. ncbi [Changes of proteomics in the lung of rats subjected to acrolein inhalation after enalapril administration]
    Yun Hui Zhang
    People s Hospital of Yunnan Province, Kunming 65000, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 41:273-5, 279. 2010
    ..To study the molecular mechanism of enalapril on rat chronic bronchopneumonia model with proteomics method...
  9. doi Protein biomarkers for in vitro testing of embryotoxicity
    Karlfried Groebe
    ProteoSys AG, Carl Zeiss Str 51, D 55129 Mainz, Germany
    J Proteome Res 9:5727-38. 2010
    ..On the other hand, Heat shock protein 8 and Fscn1 protein were down-regulated by all compounds from both clusters...
  10. ncbi Propofol anaesthesia alters the cerebral proteome differently from sevoflurane anaesthesia
    Yoshiaki Tsuboko
    Department of Anaesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    Biomed Res 32:55-65. 2011
    ..This study highlights the power of proteomic studies in assessing the effects of certain anaesthetics on the integrity of neuronal structure and function...
  11. doi Brain proteome alterations of Atlantic cod (Gadus morhua) exposed to PCB 153
    Karin Berg
    Department of Molecular Biology, University of Bergen, PB 7803, N 5020 Bergen, Norway
    Aquat Toxicol 105:206-17. 2011
    ..Our findings constitute novel clues for further research on PCB 153 mode of action in brain, and a proper selection of proteins may, following validation, be applicable in a panel of biomarkers for aquatic environmental monitoring...
  12. pmc Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis
    James D Bortner
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Proteome Res 8:4050-61. 2009
    ..Identification of these proteins in surrogate tissue in future studies would be highly useful in early detection of lung adenocarcinoma and clinical chemoprevention trials...
  13. doi Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke
    Fransisca Indraswari
    Department of Anatomy, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore
    Neurochem Int 55:235-42. 2009
    ....
  14. ncbi Transcript analyses of stromal cell derived factors (SDFs): SDF-2, SDF-4 and SDF-5 reveal a different pattern of expression and prognostic association in human breast cancer
    Hua Kang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Oncol 35:205-11. 2009
    ..These SDFs thus have prognostic value and warrant further investigation in their biological functions and clinical value...
  15. ncbi The human dihydropyrimidinase-related protein 2 gene on chromosome 8p21 is associated with paranoid-type schizophrenia
    Kenji Nakata
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Biol Psychiatry 53:571-6. 2003
    ..In addition, the DRP-2 gene (Dihydropyrimidinase-like 2; DPYSL2) is located on chromosome 8p21, a region that has been implicated in schizophrenia in genetic linkage studies...
  16. ncbi Characterization of pancreatic ERj3p, a homolog of yeast DnaJ-like protein Scj1p
    Christiane Bies
    Medizinische Biochemie and Molekularbiologie, Universitat des Saarlandes, D 66421 Homburg, Germany
    Biol Chem 385:389-95. 2004
    ..Furthermore, we found that ERj3p interacts with SDF2L1 protein that may be involved in protein O-glycosylation...
  17. ncbi An investigation of the dihydropyrimidinase-like 2 (DPYSL2) gene in schizophrenia: genetic association study and expression analysis
    Xinzhi Zhao
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Int J Neuropsychopharmacol 9:705-12. 2006
    ....
  18. ncbi Changes of the cortex proteome and Apolipoprotein E in transgenic mouse models of Alzheimer's Disease
    O Carrette
    Neuroproteomics Group, Department of Structural Biology and Bioinformatics, Geneva University, Faculty of Medicine, Geneva, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 840:1-9. 2006
    ..These proteins and their modification probably play a role in the amyloid aggregate formation in these mice...
  19. ncbi Oxidative stress in the aging murine olfactory bulb: redox proteomics and cellular localization
    Radhika A Vaishnav
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci Res 85:373-85. 2007
    ..These results indicate that specific carbonylated proteins, including those in astrocytes and mitral/tufted neurons, and nitrated proteins in the vasculature are molecular substrates of age-related olfactory dysfunction...
  20. ncbi [Effect of low dose radiation on human [corrected] bone marrow mesenchymal stem cells by using proteomic analysis]
    Yi Qiong Zhang
    Department of Hematology and Onocology, The First Clinical Hospital, Jilin University, Changchun 130021, Jilin Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:151-5. 2008
    ..The study provides some new explanation for the mechanism of low dose radiation injury...
  21. doi Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area--possible novel signalling pathways
    A Tsolakidou
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804, Munich, Germany
    Mol Cell Neurosci 38:444-52. 2008
    ..Furthermore, we focused in particular on dihydropyrimidinase like 2, to which we provide evidence for its regulation by NeuroD, an important factor for neuronal activity-..
  22. pmc SDF2L1, a component of the endoplasmic reticulum chaperone complex, differentially interacts with {alpha}-, {beta}-, and {theta}-defensin propeptides
    Prasad Tongaonkar
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 284:5602-9. 2009
    ..for a yeast two-hybrid screen that identified rhesus macaque stromal cell-derived factor 2-like protein 1 (SDF2L1), as an interactor...
  23. doi Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion
    Shinji Oikawa
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Free Radic Biol Med 46:1472-7. 2009
    ..Therefore, ischemia-reperfusion-induced oxidative damage to these proteins in the CA1 may lead to loss of the neuroprotective function, which contributes to neuronal death...
  24. ncbi Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family
    S Fukuda
    Second Department of Surgery, Department of Urology, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 0037, Japan
    Biochem Biophys Res Commun 280:407-14. 2001
    We isolated murine and human cDNAs for SDF2L1 (stromal cell-derived factor 2-like1) and characterized the genomic structures...