Gene Symbol: SDCBP
Description: syndecan binding protein
Alias: MDA-9, MDA9, ST1, SYCL, TACIP18, syntenin-1, melanoma differentiation associated protein-9, pro-TGF-alpha cytoplasmic domain-interacting protein 18, scaffold protein Pbp1, syndecan binding protein (syntenin), syndecan-binding protein 1
Species: human
Products:     SDCBP

Top Publications

  1. Tomoda T, Kim J, Zhan C, Hatten M. Role of Unc51.1 and its binding partners in CNS axon outgrowth. Genes Dev. 2004;18:541-58 pubmed
    ..Thus, our results demonstrate that the Unc51.1-containing protein complex governs axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. ..
  2. Hwangbo C, Kim J, Lee J, Lee J. Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin. Cancer Res. 2010;70:1645-55 pubmed publisher
    ..In summary, our findings offer evidence that mda-9/syntenin acts as a molecular adaptor linking PKCalpha and FAK activation in a pathway of FN adhesion by human breast cancer and melanoma cells. ..
  3. Boukerche H, Su Z, Prévot C, Sarkar D, Fisher P. mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src. Proc Natl Acad Sci U S A. 2008;105:15914-9 pubmed publisher
    ..These provocative findings highlight mda-9/syntenin and its interacting partners as promising therapeutic targets for intervention of metastasis. ..
  4. Torres R, Firestein B, Dong H, Staudinger J, Olson E, Huganir R, et al. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron. 1998;21:1453-63 pubmed
    ..Thus, PDZ proteins may play critical roles in localizing vertebrate receptor tyrosine kinases and/or their ligands and may be particularly important for Eph function in guidance or patterning or at the synapse. ..
  5. Luyten A, Mortier E, Van Campenhout C, Taelman V, Degeest G, Wuytens G, et al. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. Mol Biol Cell. 2008;19:1594-604 pubmed publisher
    ..We propose that syntenin is a novel component of the Wnt signal transduction cascade and that it might function as a direct intracellular link between Frizzled and syndecans. ..
  6. Boukerche H, Aissaoui H, Prevost C, Hirbec H, Das S, Su Z, et al. Src kinase activation is mandatory for MDA-9/syntenin-mediated activation of nuclear factor-kappaB. Oncogene. 2010;29:3054-66 pubmed publisher
    ..These findings underscore PDZ domains of MDA-9/syntenin as promising potential therapeutic targets for intervening in a decisive component of cancer progression, namely, metastatic tumor spread. ..
  7. Estrach S, Legg J, Watt F. Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture. J Cell Sci. 2007;120:2944-52 pubmed
    ..We propose that syntenin binding to Delta1 plays a dual role in promoting intercellular adhesion and regulating Notch signalling. ..
  8. Gimferrer I, Ibáñez A, Farnós M, Sarrias M, Fenutría R, Roselló S, et al. The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains. J Immunol. 2005;175:1406-14 pubmed
    ..Therefore, we propose that syntenin-1 may function as a scaffolding protein coupling CD6 and most likely other lymphocyte receptors to cytoskeleton and/or signaling effectors during IS maturation. ..
  9. Sarkar D, Boukerche H, Su Z, Fisher P. mda-9/syntenin: recent insights into a novel cell signaling and metastasis-associated gene. Pharmacol Ther. 2004;104:101-15 pubmed
    ..In this review, we discuss the identification, structure and function of mda-9/syntenin and delineate future studies to address its role in regulating key physiological and pathological processes. ..

More Information


  1. Koo T, Lee J, Kim E, Kim K, Kim H, Lee J. Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines. Oncogene. 2002;21:4080-8 pubmed
    ..This is the first demonstration that syntenin, a PDZ motif-containing protein, can be overexpressed during the metastatic progression of human breast and gastric cancer cells and that it can function as a metastasis-inducing gene. ..
  2. Zimmermann P, Meerschaert K, Reekmans G, Leenaerts I, Small J, Vandekerckhove J, et al. PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membrane. Mol Cell. 2002;9:1215-25 pubmed
    ..These observations suggest that local changes in phosphoinositide concentration control the association of PDZ proteins with their target receptors at the plasma membrane. ..
  3. Hwangbo C, Park J, Lee J. mda-9/Syntenin protein positively regulates the activation of Akt protein by facilitating integrin-linked kinase adaptor function during adhesion to type I collagen. J Biol Chem. 2011;286:33601-12 pubmed publisher
    ..Thus, our study defines the role of mda-9/syntenin in ILK adaptor function and describes a new mechanism of mda-9/syntenin for regulation of cell migration. ..
  4. Sala Valdés M, Gordón Alonso M, Tejera E, Ibáñez A, Cabrero J, Ursa A, et al. Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions. J Cell Sci. 2012;125:1235-46 pubmed publisher
  5. Meerschaert K, Bruyneel E, De Wever O, Vanloo B, Boucherie C, Bracke M, et al. The tandem PDZ domains of syntenin promote cell invasion. Exp Cell Res. 2007;313:1790-804 pubmed
  6. Boukerche H, Su Z, Emdad L, Baril P, Balme B, Thomas L, et al. mda-9/Syntenin: a positive regulator of melanoma metastasis. Cancer Res. 2005;65:10901-11 pubmed
    ..Based on its ability to directly alter metastasis, mda-9/syntenin provides a promising new focus for melanoma cancer research with potential therapeutic applications for metastatic diseases. ..
  7. Helmke B, Polychronidis M, Benner A, Thome M, Arribas J, Deichmann M. Melanoma metastasis is associated with enhanced expression of the syntenin gene. Oncol Rep. 2004;12:221-8 pubmed
  8. Das S, Bhutia S, Kegelman T, Peachy L, Oyesanya R, Dasgupta S, et al. MDA-9/syntenin: a positive gatekeeper of melanoma metastasis. Front Biosci (Landmark Ed). 2012;17:1-15 pubmed
    ..The present review provides a current perspective of our understanding of the important features of MDA-9/syntenin and its significant role in tumor cell metastasis with special focus on molecular mechanism of action. ..
  9. Kang B, Cooper D, Jelen F, Devedjiev Y, Derewenda U, Dauter Z, et al. PDZ tandem of human syntenin: crystal structure and functional properties. Structure. 2003;11:459-68 pubmed
    ..The independent binding of merlin by PDZ1 and syndecan-4 by PDZ2 provides direct evidence for the coupling of syndecan-mediated signaling to actin regulation by merlin. ..
  10. Bass M, Humphries M. Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. Biochem J. 2002;368:1-15 pubmed
    ..These conclusions also offer an insight into the role of syndecan-4 in vivo, and are consistent with phenotypes generated as a consequence of abnormal syndecan-4 expression in pathologies and gene disruption studies. ..
  11. Baietti M, Zhang Z, Mortier E, Melchior A, Degeest G, Geeraerts A, et al. Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Nat Cell Biol. 2012;14:677-85 pubmed publisher
    ..This study identifies a key role for syndecan-syntenin-ALIX in membrane transport and signalling processes. ..
  12. Geijsen N, Uings I, Pals C, Armstrong J, McKinnon M, Raaijmakers J, et al. Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. Science. 2001;293:1136-8 pubmed
    ..Association of syntenin with IL-5Ralpha was required for IL-5-mediated activation of Sox4. These studies identify a mechanism of transcriptional activation by cytokine-specific receptor subunits. ..
  13. Jannatipour M, Dion P, Khan S, Jindal H, Fan X, Laganiere J, et al. Schwannomin isoform-1 interacts with syntenin via PDZ domains. J Biol Chem. 2001;276:33093-100 pubmed
    ..Together, these results provide the first functional clue to the existence of schwannomin isoforms and could unravel novel pathways for the transport and subcellular localization of schwannomin in vivo. ..
  14. Grootjans J, Reekmans G, Ceulemans H, David G. Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin. J Biol Chem. 2000;275:19933-41 pubmed
    ..In general, an intramolecular combination of PDZ domains that are weak, taken individually, would appear to be designed to detect rather than drive the formation of specific molecular assemblies. ..
  15. Lin J, Jiang H, Fisher P. Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene. Gene. 1998;207:105-10 pubmed
  16. Grootjans J, Zimmermann P, Reekmans G, Smets A, Degeest G, Durr J, et al. Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. Proc Natl Acad Sci U S A. 1997;94:13683-8 pubmed
    ..We propose that syntenin may function as an adaptor that couples syndecans to cytoskeletal proteins or cytosolic downstream signal-effectors. ..
  17. Li A, Li H, Jin B, Ye Q, Zhou T, Yu X, et al. A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis. J Biol Chem. 2004;279:49251-8 pubmed
    ..Therefore, eIF5A seems to be a previously unrecognized regulator of p53 that may define a new pathway for p53-dependent apoptosis, and syntenin might regulate p53 by balancing the regulation of eIF5A signaling to p53 for apoptosis. ..
  18. Zimmermann P, Tomatis D, Rosas M, Grootjans J, Leenaerts I, Degeest G, et al. Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments. Mol Biol Cell. 2001;12:339-50 pubmed
    ..These results suggest a role for syntenin in the composition of adherens junctions and the regulation of plasma membrane dynamics, and imply a potential role for syntenin in nuclear processes. ..
  19. Koroll M, Rathjen F, Volkmer H. The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. J Biol Chem. 2001;276:10646-54 pubmed
    ..Here, we demonstrate that rat syntenin-1, previously published as syntenin, mda-9, or TACIP18 in human, is a neurofascin-binding protein that exhibits a wide-spread tissue expression pattern with a relative ..
  20. Seguí R, Muñoz Antoli C, Klisiowicz D, Oishi C, Köster P, de Lucio A, et al. Prevalence of intestinal parasites, with emphasis on the molecular epidemiology of Giardia duodenalis and Blastocystis sp., in the Paranaguá Bay, Brazil: a community survey. Parasit Vectors. 2018;11:490 pubmed publisher
    ..of 102 Blastocystis-positive samples were successfully subtyped at the SSU rRNA gene revealing the presence of ST1 (36.3%), ST2 (15.7%), ST3 (41.2%), ST4 (2.9%), ST6 (1.0%) and ST8 (2.9%)...
  21. Bojarska A, Molska E, Janas K, Skoczyńska A, Stefaniuk E, Hryniewicz W, et al. Streptococcus suis in invasive human infections in Poland: clonality and determinants of virulence and antimicrobial resistance. Eur J Clin Microbiol Infect Dis. 2016;35:917-25 pubmed publisher
    ..All isolates represented sequence type 1 (ST1) and were suggested to be serotype 2...
  22. Manara S, Pasolli E, Dolce D, Ravenni N, Campana S, Armanini F, et al. Whole-genome epidemiology, characterisation, and phylogenetic reconstruction of Staphylococcus aureus strains in a paediatric hospital. Genome Med. 2018;10:82 pubmed publisher
    ..aureus. We also found a recently diverged ST1-SCCmecIV-t127 PVL- clone suspected to be hospital-specific, but time-resolved integrative phylogenetic analysis ..
  23. Dacal E, Saugar J, de Lucio A, Hernández de Mingo M, Robinson E, Köster P, et al. Prevalence and molecular characterization of Strongyloides stercoralis, Giardia duodenalis, Cryptosporidium spp., and Blastocystis spp. isolates in school children in Cubal, Western Angola. Parasit Vectors. 2018;11:67 pubmed publisher
    ..A total of 75 Blastocystis isolates were assigned to the subtypes ST1 (30.7%), ST2 (30.7%), ST3 (36.0%), ST5 (1.3%) and ST7 (1.3%), respectively...
  24. Abraham S, Jordan D, Wong H, Johnson J, Toleman M, Wakeham D, et al. First detection of extended-spectrum cephalosporin- and fluoroquinolone-resistant Escherichia coli in Australian food-producing animals. J Glob Antimicrob Resist. 2015;3:273-277 pubmed publisher
    ..Most ESC- and FQ-resistant isolates represented globally disseminated E. coli lineages (ST117, ST744, ST10 and ST1). Only a single porcine E. coli isolate (ST100) was identified as a classic porcine enterotoxigenic E...
  25. Omaleki L, Browning G, Allen J, Markham P, Barber S. Molecular epidemiology of an outbreak of clinical mastitis in sheep caused by Mannheimia haemolytica. Vet Microbiol. 2016;191:82-7 pubmed publisher
    ..Multilocus sequence typing of the M. haemolytica isolates revealed most of the isolates belonged to ST1 with no association between the PFGE and MLST fingerprints of the isolates...
  26. Coombs G, Daley D, Thin Lee Y, Pearson J, Robinson J, Nimmo G, et al. Australian Group on Antimicrobial Resistance Australian Staphylococcus aureus Sepsis Outcome Programme annual report, 2014. Commun Dis Intell Q Rep. 2016;40:E244-54 pubmed
    ..polyclonal, almost 44% of community-associated clones were characterised as ST93-IV [2B] (Queensland CA-MRSA) and ST1-IV [2B] (WA1)...
  27. Zhang J, Cao Y, Wang J, Guo X, Zheng Y, Zhao W, et al. Physicochemical characteristics and bioactivities of the exopolysaccharide and its sulphated polymer from Streptococcus thermophilus GST-6. Carbohydr Polym. 2016;146:368-75 pubmed publisher
    ..80:1.03 with identical primary structure to the EPS from S. thermophilus ST1 reported previously. The purified EPS was sulphated at a sulphonation degree of 0.26±0...
  28. Hirashima Y, Manchanayake T, Yano T, Kitahara S, Koreeda T, Kamimura S, et al. Development of molecular diagnostic protocols for detecting three types of Entamoeba from diarrheal and asymptomatic pigs and environmental moist soils. Parasitol Res. 2017;116:2001-2007 pubmed publisher
    ..We identified single and mixed infections of E. suis and E. polecki ST1 and ST3 in paraffin sections or fecal samples from affected pigs...
  29. Kegelman T, Wu B, Das S, Talukdar S, Beckta J, Hu B, et al. Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin. Proc Natl Acad Sci U S A. 2017;114:370-375 pubmed publisher
    ..hybridization identified melanoma differentiation-associated gene 9 [MDA-9/Syntenin; syndecan-binding protein (SDCBP)] as a differentially regulated gene associated with aggressive cancer phenotypes in melanoma...
  30. Walter R, Werner R, Vollbrecht C, Hager T, Flom E, Christoph D, et al. ACTB, CDKN1B, GAPDH, GRB2, RHOA and SDCBP Were Identified as Reference Genes in Neuroendocrine Lung Cancer via the nCounter Technology. PLoS ONE. 2016;11:e0165181 pubmed publisher
    ..ACTB, CDKN1B, GAPDH, GRB2, RHOA and SDCBP were identified as constantly expressed genes with high stability (M-)values according to geNorm, NormFinder and ..
  31. Piran A, Shahcheraghi F, Solgi H, Rohani M, Badmasti F. A reliable combination method to identification and typing of epidemic and endemic clones among clinical isolates of Acinetobacter baumannii. Infect Genet Evol. 2017;54:501-507 pubmed publisher
    ..baumannii with ORF pattern B and blaOXA-66 gene. Only 7% (4/57) of MDR isolates belonged to ST1 with ORF pattern A and blaOXA-69 gene...
  32. Tan R, Patni H, Tandon P, Luan L, Sharma B, Salhan D, et al. Nef interaction with actin compromises human podocyte actin cytoskeletal integrity. Exp Mol Pathol. 2013;94:51-7 pubmed publisher
    ..Functionally, Nef/CIHPs displayed diminished attachment and enhanced detachment to their substrate. These findings indicate that Nef interaction with actin compromises the podocyte cytoskeleton integrity. ..
  33. Takeuchi F, Ogasawara Y, Kato K, Sekizuka T, Nozaki T, Sugita Konishi Y, et al. Genetic variants of Kudoa septempunctata (Myxozoa: Multivalvulida), a flounder parasite causing foodborne disease. J Fish Dis. 2016;39:667-72 pubmed publisher
    ..The 104 samples were classified into three genotypes, ST1, ST2 and ST3...
  34. Mirjalali H, Abbasi M, Naderi N, Hasani Z, Mirsamadi E, Stensvold C, et al. Distribution and phylogenetic analysis of Blastocystis sp. subtypes isolated from IBD patients and healthy individuals in Iran. Eur J Clin Microbiol Infect Dis. 2017;36:2335-2342 pubmed publisher
    ..05), but not among healthy controls. No significant correlation between gender and colonization was observed. ST1 and ST3 were obtained from 1 (12.5%) and 7 (87...
  35. . Letter: The condition of psychiatry. N Engl J Med. 1975;292:982 pubmed
  36. Forsell J, Granlund M, Samuelsson L, Koskiniemi S, Edebro H, Evengard B. High occurrence of Blastocystis sp. subtypes 1-3 and Giardia intestinalis assemblage B among patients in Zanzibar, Tanzania. Parasit Vectors. 2016;9:370 pubmed publisher
    ..The Blastocystis subtype distribution was ST1 34.0 %, ST2 26.4 %, ST3 25.5 %, ST7 0.9 %, and 13.2 % were positive only by qPCR (non-typable)...
  37. Hirai Y, Suzuki T, Inaba N, Minoguchi N, Takamatsu D. Existence of Paenibacillus larvae genotypes ERIC I-ST2, ERIC I-ST15 and ERIC II-ST10 in the western region of Aichi prefecture, Japan. J Vet Med Sci. 2016;78:1195-9 pubmed publisher
    ..into four genotypes by a repetitive-element PCR (ERIC I-IV) and 21 sequence types by multilocus sequence typing (ST1-21). In this study, we genotyped Japanese P...
  38. Cheung G, Yeh A, Kretschmer D, Duong A, Tuffuor K, Fu C, et al. Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S. Sci Rep. 2015;5:18023 pubmed publisher
    ..This variant is a characteristic of the subspecies S. argenteus and S. aureus sequence types ST1 and ST59, the latter representing the most frequent cause of community-associated infections in Asia...
  39. Cetinkaya S, Mestan E, Acir N, Cetinkaya Y, Dadaci Z, Yener H. The course of dry eye after phacoemulsification surgery. BMC Ophthalmol. 2015;15:68 pubmed publisher
    ..441, P = 0.078, P = 0.145, P = 0.125). The mean postoperative 1st day, 1st week and 1st month Schirmer Test 1 (ST1) values were significantly lower than preoperative ST1 value (P < 0.001, P < 0.001, P < 0...
  40. Karasartova D, Güreser A, Ruh E, Türegün Atasoy B, Calgin M, Tasci L, et al. An alternative DNA extraction method for detection of Blastocystis spp. in human fecal samples. Exp Parasitol. 2018;186:36-41 pubmed publisher PCR-sand method were successfully sequenced, and Blastocystis subtypes (STs) were identified as ST3, ST2 and ST1. In conclusion, the present study indicates that the sand method provides a simple, rapid and inexpensive procedure ..
  41. Dasgupta S, Menezes M, Das S, Emdad L, Janjić A, Bhatia S, et al. Novel role of MDA-9/syntenin in regulating urothelial cell proliferation by modulating EGFR signaling. Clin Cancer Res. 2013;19:4621-33 pubmed publisher
    ..03) and invasion (P=0.04) was also evident. Our findings indicate that MDA-9/Syntenin might provide an attractive target for developing detection, monitoring, and therapeutic strategies for managing UCC. ..
  42. Marx B, Miller Lazic D, Doorbar J, Majewski S, Hofmann K, Hufbauer M, et al. HPV8-E6 Interferes with Syntenin-2 Expression through Deregulation of Differentiation, Methylation and Phosphatidylinositide-Kinase Dependent Mechanisms. Front Microbiol. 2017;8:1724 pubmed publisher
    ..Collectively, our data demonstrates that Syntenin-2 is regulated through multiple mechanisms and that downregulation of Syntenin-2 expression may contribute to E6 mediated dedifferentiation of infected skin cells. ..
  43. Zhang B, Yang X, Tiberi M. Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants. Cell Signal. 2015;27:2014-25 pubmed publisher
    ..contribute to the structural basis for GPCR functionality, we have designed human D1-class receptor mutants (hD1-ST1 and hD5-ST1) whereby all Ser and Thr of IL1 and IL1/TM2 juncture have been replaced by Ala and Val, respectively...
  44. Rabouille C. KRS: A cut away from release in exosomes. J Cell Biol. 2017;216:1891-1893 pubmed publisher
    ..Kim et al. (2017. J. Cell Biol. now demonstrate that cleavage of the KRS by caspase-8 inside cells triggers its interaction with syntenin and its release in inflammatory exosomes. ..
  45. Cheng J, Yang Q, Xiao M, Yu S, Zhou M, Kudinha T, et al. High in vitro activity of fidaxomicin against Clostridium difficile isolates from a university teaching hospital in China. J Microbiol Immunol Infect. 2018;51:411-416 pubmed publisher
    ..001). The MIC values of fidaxomicin, metronidazole, vancomycin and moxifloxacin against the 3 ST1 isolates were higher than for other STs...
  46. Das S, Bhutia S, Sokhi U, Azab B, Su Z, Boukerche H, et al. Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma. Cancer Res. 2012;72:6217-26 pubmed publisher
    ..Taken together, these findings establish RKIP as an inhibitor of MDA-9-dependent melanoma metastasis, with potential implications for targeting this process therapeutically. ..
  47. Yamaguchi K, Takanashi T, Nasu K, Tamai K, Mochizuki M, Satoh I, et al. Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activation. Cancer Sci. 2016;107:638-43 pubmed publisher
    ..serial transplantation in NOG mice, we established two highly tumorigenic adult T-cell leukemia-derived cell lines, ST1-N6 and TL-Om1-N8. When transplanted s.c...
  48. Chiasserini D, Mazzoni M, Bordi F, Sennato S, Susta F, Orvietani P, et al. Identification and Partial Characterization of Two Populations of Prostasomes by a Combination of Dynamic Light Scattering and Proteomic Analysis. J Membr Biol. 2015;248:991-1004 pubmed publisher
    ..The different size and protein profile in the two subpopulations of prostasomes might support differential roles of the semen vesicles toward the target cells, and/or different secretion pathways from the organ of origin. ..
  49. Garrido Urbani S, Garg P, Ghossoub R, Arnold R, Lembo F, Sundell G, et al. Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin. FEBS Lett. 2016;590:3-12 pubmed publisher
    ..We validate the interaction with nectin-1 through orthogonal assays. The study demonstrates the power of ProP-PD as a complementary approach to uncover interactions of potential biological relevance. ..
  50. Imjeti N, Menck K, Egea Jimenez A, Lecointre C, Lembo F, Bouguenina H, et al. Syntenin mediates SRC function in exosomal cell-to-cell communication. Proc Natl Acad Sci U S A. 2017;114:12495-12500 pubmed publisher
    ..Our study uncovers a function of SRC in cell-cell communication, supported by syntenin exosomes, which is likely to contribute to tumor-host interactions. ..
  51. Fu L, Huang M, Zhang X, Yang X, Liu Y, Zhang L, et al. Frequency of virulence factors in high biofilm formation blaKPC-2 producing Klebsiella pneumoniae strains from hospitals. Microb Pathog. 2018;116:168-172 pubmed publisher
    ..showed that 23/43 strains were ST11, followed by ST433(4/43), ST107(4/43), ST690(4/43), ST304(2/43), ST2058(1/43), ST1(1/43), ST146(1/43), ST914(1/43), ST2636(1/43), ST2637(1/43)...
  52. Xue W, Zhu M, Zhu B, Huang J, Sun Q, Miao Y, et al. Long-term impact of dry eye symptoms on vision-related quality of life after phacoemulsification surgery. Int Ophthalmol. 2019;39:419-429 pubmed publisher
    ..Visual acuity, tear film breakup time (BUT), and Schirmer test 1 (ST1) were measured before and 1, 3, and 6 months after surgery...
  53. Xi Y, Seyoum H, Liu M. Role of SULT-mediated sulfation in the biotransformation of 2-butoxyethanol and sorbitan monolaurate: A study using zebrafish SULTs. Aquat Toxicol. 2016;177:19-21 pubmed publisher
    ..A systematic analysis of 18 zebrafish SULTs revealed that SULT3 ST1 showed the strongest sulfating activity toward 2-butoxyethanol, while SULT1 ST3 displayed the strongest sulfating ..
  54. Sarmento Dias M, Santos Araújo C, Poínhos R, Oliveira B, Sousa M, Simões Silva L, et al. Phase Angle Predicts Arterial Stiffness and Vascular Calcification in Peritoneal Dialysis Patients. Perit Dial Int. 2017;37:451-457 pubmed publisher
    ..Sixty-one stable adult PD patients were evaluated in a cross-sectional study (ST1). Phase angle was measured by multifrequency bioimpedance analysis (InbodyS10, Biospace, Korea) at 50 kHz...
  55. D Alfonso R, Santoro M, Essi D, Monsia A, Kaboré Y, Glé C, et al. Blastocystis in Côte d'Ivoire: molecular identification and epidemiological data. Eur J Clin Microbiol Infect Dis. 2017;36:2243-2250 pubmed publisher
    ..Overall, a prevalence of 58.2% was observed in humans and subtypes ST1(50.0%), ST2 (22.0%) and ST3 (28.1%) were identified...
  56. Wang L, Pan S, Chang Y, Hung P, Kao S, Wang W, et al. MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma. Oncotarget. 2016;7:386-401 pubmed publisher
    ..Our findings provide evidence that MDA-9/Syntenin acts as a pivotal adaptor of Slug and it transcriptionally enhances Slug-mediated EMT to promote cancer invasion and metastasis. ..
  57. Zhang W, Ren G, Zhao W, Yang Z, Shen Y, Sun Y, et al. Genotyping of Enterocytozoon bieneusi and Subtyping of Blastocystis in Cancer Patients: Relationship to Diarrhea and Assessment of Zoonotic Transmission. Front Microbiol. 2017;8:1835 pubmed publisher
    ..Two E. bieneusi genotypes (D and a novel one named as HLJ-CP1) and two Blastocystis subtypes (ST1 and ST3) were identified with three novel ST1 sequences...
  58. Chen F, Du Y, Zhang Z, Chen G, Zhang M, Shu H, et al. Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling. Cell Signal. 2008;20:666-74 pubmed publisher
    ..These findings suggest that syntenin is a physiological suppressor of TRAF6 and plays an inhibitory role in IL-1R- and TLR4- mediated NF-kappaB activation pathways. ..
  59. Wang R, Li L, Huang T, Lei A, Huang Y, Luo F, et al. Genomic comparison of virulent and non-virulent serotype V ST1 Streptococcus agalactiae in fish. Vet Microbiol. 2017;207:164-169 pubmed publisher
    ..Although the invasive disease caused by ST1 GBS in non-pregnant adults and cows is increasing worldwide, infection of fish by ST1 GBS has not been reported...
  60. Hirbec H, Francis J, Lauri S, Braithwaite S, Coussen F, Mulle C, et al. Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Neuron. 2003;37:625-38 pubmed
  61. Okumura F, Yoshida K, Liang F, Hatakeyama S. MDA-9/syntenin interacts with ubiquitin via a novel ubiquitin-binding motif. Mol Cell Biochem. 2011;352:163-72 pubmed publisher
  62. Menezes M, Shen X, Das S, Emdad L, Sarkar D, Fisher P. MDA-9/Syntenin (SDCBP) modulates small GTPases RhoA and Cdc42 via transforming growth factor β1 to enhance epithelial-mesenchymal transition in breast cancer. Oncotarget. 2016;7:80175-80189 pubmed publisher
    ..However, the molecular mechanisms underlying this transition require further clarification. MDA-9/syntenin (SDCBP) expression is elevated in breast cancer patient samples as well as cultured breast cancer cells...
  63. Friand V, David G, Zimmermann P. Syntenin and syndecan in the biogenesis of exosomes. Biol Cell. 2015;107:331-41 pubmed publisher
    ..All these molecules appear to support the budding of SDC-syntenin and associated cargo into the lumen of endosomes. This highlights a major mechanism for the formation of intraluminal vesicles that will be released as exosomes. ..
  64. Albornos L, Martín I, Labrador E, Dopico B. Three members of Medicago truncatula ST family are ubiquitous during development and modulated by nutritional status (MtST1) and dehydration (MtST2 and MtST3). BMC Plant Biol. 2017;17:117 pubmed publisher
    ..The aim of this work was to go deeper into the role of three M. truncatula ST proteins, namely ST1, ST2 and ST3...
  65. Sira M, Yoshida T, Takeuchi M, Kashiwayama Y, Futatani T, Kanegane H, et al. A novel immunoregulatory protein in human colostrum, syntenin-1, for promoting the development of IgA-producing cells from cord blood B cells. Int Immunol. 2009;21:1013-23 pubmed publisher
    ..Moreover, we demonstrated that recombinant syntenin-1 could induce preferentially IgA production from naive B cells. These results suggest that syntenin-1 serves as one of IgA-inducing factors for B cells. ..
  66. Noradilah S, Moktar N, Anuar T, Lee I, Salleh F, Manap S, et al. Molecular epidemiology of blastocystosis in Malaysia: does seasonal variation play an important role in determining the distribution and risk factors of Blastocystis subtype infections in the Aboriginal community?. Parasit Vectors. 2017;10:360 pubmed publisher
    ..Of the 473 samples, 42.6% and 37.8% were positive for Blastocystis ST1, ST2, ST3 and ST4 during wet and dry seasons, respectively...
  67. Sulka B, Lortat Jacob H, Terreux R, Letourneur F, Rousselle P. Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitment. J Biol Chem. 2009;284:10659-71 pubmed publisher
    ..We propose that tyrosine dephosphorylation of syndecan-1 may regulate its association with cytoskeleton components. ..
  68. Kegelman T, Das S, Hu B, Bacolod M, Fuller C, Menezes M, et al. MDA-9/syntenin is a key regulator of glioma pathogenesis. Neuro Oncol. 2014;16:50-61 pubmed publisher
    ..Our findings indicate that MDA-9/syntenin is a novel and important mediator of invasion in GBM and a key regulator of pathogenesis, and we identify it as a potential target for anti-invasive treatment in human astrocytoma. ..
  69. Hwangbo C, Tae N, Lee S, Kim O, Park O, Kim J, et al. Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene. 2016;35:389-401 pubmed publisher
  70. Dutta P, O Connell K, Ozkan S, Sailer A, Dev K. The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death. J Neurochem. 2014;130:360-73 pubmed publisher
    ..These results suggest a role for PICK1 in preventing PAELR-induced cell toxicity. ..
  71. Belleza M, Reyes J, Tongol Rivera P, Rivera W. Subtype analysis of Blastocystis sp. isolates from human and canine hosts in an urban community in the Philippines. Parasitol Int. 2016;65:291-4 pubmed publisher
    ..In humans, the ST present in this study were ST1 with 22.6% (95% CI = 17.2-29.0), ST2 with 3.1% (95% CI = 1.3-6.7), ST3 with 41.4% (95% CI= 34.9-48.6), ST4 with 14...
  72. Fialka I, Steinlein P, Ahorn H, Bock G, Burbelo P, Haberfellner M, et al. Identification of syntenin as a protein of the apical early endocytic compartment in Madin-Darby canine kidney cells. J Biol Chem. 1999;274:26233-9 pubmed
    ..In addition, syntenin colocalized in the apical supranuclear region with Rab5 and Rab11; the latter is a marker for the apical recycling endosomes in MDCK cells. ..
  73. Lee H, Kim Y, Choi Y, Choi S, Hong E, Oh E. Syndecan-2 cytoplasmic domain regulates colon cancer cell migration via interaction with syntenin-1. Biochem Biophys Res Commun. 2011;409:148-53 pubmed publisher
    ..Together, the data suggest that the cytoplasmic domain of syndecan-2 regulates colon cancer cell migration via interaction with syntenin-1. ..
  74. Vandewalle Capo M, Massip C, Descours G, Charavit J, Chastang J, Billy P, et al. Minimum inhibitory concentration (MIC) distribution among wild-type strains of Legionella pneumophila identifies a subpopulation with reduced susceptibility to macrolides owing to efflux pump genes. Int J Antimicrob Agents. 2017;50:684-689 pubmed publisher
    ..with the presence of the lpeAB genes encoding a macrolide efflux pump found specifically in sequence type (ST) ST1, ST701 and closely related STs...
  75. Fernandez Larrea J, Merlos Suarez A, Urena J, Baselga J, Arribas J. A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface. Mol Cell. 1999;3:423-33 pubmed
    ..The binding specificity of one of them, TACIP18 (previously identified and named Syntenin or mda-9), coincides with that of the component that possibly mediates ..
  76. Bacolod M, Das S, Sokhi U, Bradley S, Fenstermacher D, Pellecchia M, et al. Examination of Epigenetic and other Molecular Factors Associated with mda-9/Syntenin Dysregulation in Cancer Through Integrated Analyses of Public Genomic Datasets. Adv Cancer Res. 2015;127:49-121 pubmed publisher
    ..g., interleukins), CTLA-4, and components of complement cascade pathways. Indeed, previous publications have shown that many of the aforementioned genes and pathways are associated with mda-9's functionality. ..
  77. Figueiredo B, Assis N, Morais S, Ricci N, Pinheiro C, Martins V, et al. Schistosome syntenin partially protects vaccinated mice against Schistosoma mansoni infection. PLoS Negl Trop Dis. 2014;8:e3107 pubmed publisher
    ..Our report is the first characterization of syntenin in Schistosoma mansoni and our data suggest that this protein is a potential candidate for the development of a multi-antigen vaccine to control schistosomiasis. ..
  78. Tudor C, Te Riet J, Eich C, Harkes R, Smisdom N, Bouhuijzen Wenger J, et al. Syntenin-1 and ezrin proteins link activated leukocyte cell adhesion molecule to the actin cytoskeleton. J Biol Chem. 2014;289:13445-60 pubmed publisher
  79. Dittmann K, Chaul L, Lee S, Corassin C, Fernandes de Oliveira C, Pereira De Martinis E, et al. Staphylococcus aureus in Some Brazilian Dairy Industries: Changes of Contamination and Diversity. Front Microbiol. 2017;8:2049 pubmed publisher
    ..Seven known sequence types (STs), ST1, ST5, ST30, ST97, ST126, ST188 and ST398, and four new ST were identified, ST3531, ST3540, ST3562 and ST3534...
  80. Gangemi R, Mirisola V, Barisione G, Fabbi M, Brizzolara A, Lanza F, et al. Mda-9/syntenin is expressed in uveal melanoma and correlates with metastatic progression. PLoS ONE. 2012;7:e29989 pubmed publisher
    ..The analysis of the gene expression profiles of primary human uveal melanomas showed high expression of SDCBP gene (encoding for syndecan-binding protein-1 or mda-9/syntenin), which appeared higher in patients with ..
  81. Gonzalez A, Marques L, Gomes M, Beltrão J, Pinheiro M, Esper L, et al. Methicillin resistant Staphylococcus aureus in minas frescal cheese: evaluation of classic enterotoxin genes, antimicrobial resistance and clonal diversity. FEMS Microbiol Lett. 2017;: pubmed publisher
    ..MRSA isolates showed, by multilocus sequence typing (MLST), sequence types ST1, ST5, ST72 and ST4304 (new ST) and S. aureus protein A (spa type) t127, t568 and t2703...
  82. Andersen J, Shoup M, Robinson C, Britton R, Olsen K, Barrangou R. CRISPR Diversity and Microevolution in Clostridium difficile. Genome Biol Evol. 2016;8:2841-55 pubmed publisher
    ..Spacer polymorphisms of conserved arrays were instrumental for differentiating closely related strains, e.g., ST1/RT027/B1 strains and pathogenicity locus encoding ST3/RT001 strains...
  83. Villegas Gómez I, Martínez Hernández F, Urrea Quezada A, González Díaz M, Durazo M, Hernández J, et al. Comparison of the genetic variability of Blastocystis subtypes between human carriers from two contrasting climatic regions of México. Infect Genet Evol. 2016;44:334-340 pubmed publisher
    ..Blastocystis exhibits high genetic polymorphism and at least 17 subtypes (ST) have been identified; ST1-ST3 are frequently found in the Americas...
  84. Reyes J, Chaffer M, Rodriguez Lecompte J, Sanchez J, Zadoks R, Robinson N, et al. Short communication: Molecular epidemiology of Streptococcus agalactiae differs between countries. J Dairy Sci. 2017;100:9294-9297 pubmed publisher
    ..Isolates belonged to sequence type 248 [clonal complex (CC) 103; n = 30), ST1 (CC1; n = 6) or ST22 (CC22; n = 4)], whereas members of CC67/61, the dominant type in North America, were not ..
  85. Zhuan B, Yu Y, Yang Z, Zhao X, Li P. Mechanisms of oxidative stress effects of the NADPH oxidase-ROS-NF-?B transduction pathway and VPO1 on patients with chronic obstructive pulmonary disease combined with pulmonary hypertension. Eur Rev Med Pharmacol Sci. 2017;21:3459-3464 pubmed
    ..427, p<0.05). The NADPH oxidase-ROS-NF-?B transduction pathway, VPO1, oxidative stress and their complicated interactions are implicated in the occurrence and development of COPD combined with PH. ..
  86. Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley J, et al. The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. J Biol Chem. 2002;277:15221-4 pubmed
    ..These data also suggest that the structural determinants involved in PDZ interactions are more complex than originally envisaged. ..
  87. Egea Jimenez A, Gallardo R, Garcia Pino A, Ivarsson Y, Wawrzyniak A, Kashyap R, et al. Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. Nat Commun. 2016;7:12101 pubmed publisher
    ..This study contributes to our understanding of the biology of PDZ proteins as key players in membrane compartmentalization and dynamics. ..
  88. El Badry A, Abd El Wahab W, Hamdy D, Aboud A. Blastocystis subtypes isolated from irritable bowel syndrome patients and co-infection with Helicobacter pylori. Parasitol Res. 2018;117:127-137 pubmed publisher
    ..2). There was a predominance of Blastocystis sp. ST3 (81%) followed by ST1 (19%). Blastocystis culture results (19.1%) were superior than microscopy (16.5%)...
  89. Kang B, Devedjiev Y, Derewenda U, Derewenda Z. The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography. J Mol Biol. 2004;338:483-93 pubmed
    ..Most hydrogen atoms are easily identifiable in the electron density and weak hydrogen bonds of the C-H...O type are clearly visible between the beta-strands. The study sets a new standard for high-resolution protein crystallography. ..