Gene Symbol: SDC4
Description: syndecan 4
Alias: SYND4, syndecan-4, amphiglycan, ryudocan amphiglycan, ryudocan core protein, syndecan 4 (amphiglycan, ryudocan), syndecan proteoglycan 4
Species: human
Products:     SDC4

Top Publications

  1. Vuoriluoto K, Högnäs G, Meller P, Lehti K, Ivaska J. Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through ?2?1 integrin and MT1-MMP. Matrix Biol. 2011;30:207-17 pubmed publisher
  2. Horowitz A, Simons M. Regulation of syndecan-4 phosphorylation in vivo. J Biol Chem. 1998;273:10914-8 pubmed
    ..We conclude that the cytoplasmic tail of syndecan-4 is subject to in vivo phosphorylation on Ser183, which is regulated by the activities of a novel PKC isozyme and a bFGF-dependent serine/threonine phosphatase. ..
  3. Horowitz A, Tkachenko E, Simons M. Fibroblast growth factor-specific modulation of cellular response by syndecan-4. J Cell Biol. 2002;157:715-25 pubmed
    ..These results suggest that PKCalpha activation and PDZ-mediated formation of a serine/threonine phosphatase-containing complex by syndecan-4 are downstream events of FGF2 signaling. ..
  4. Chung J, Bonkobara M, Tomihari M, Cruz P, Ariizumi K. The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell responses. Eur J Immunol. 2009;39:965-74 pubmed publisher
    ..Our findings indicate that the DC-HIL/SD-4 pathway can be manipulated to treat T-cell-driven disorders in humans. ..
  5. Woods A, Couchman J. Syndecan 4 heparan sulfate proteoglycan is a selectively enriched and widespread focal adhesion component. Mol Biol Cell. 1994;5:183-92 pubmed
    ..The identity of the proteoglycan has remained elusive, but we now report that syndecan 4 (ryudocan/amphiglycan) is present in focal adhesions of a number of cell types...
  6. Lee D, Oh E, Woods A, Couchman J, Lee W. Solution structure of a syndecan-4 cytoplasmic domain and its interaction with phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 1998;273:13022-9 pubmed
    ..These findings reveal that PIP2 promotes oligomerization of syndecan-4 cytoplasmic domain for transmembrane signaling and cell-matrix adhesion. ..
  7. Cohen A, Woods D, Marfatia S, Walther Z, Chishti A, Anderson J, et al. Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. J Cell Biol. 1998;142:129-38 pubmed
    ..1. Like other membrane-associated guanylate kinases, its multidomain structure enables it to act as a scaffold at the membrane, potentially recruiting multiple proteins and coordinating signal transduction. ..
  8. Gao Y, Li M, Chen W, Simons M. Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration. J Cell Physiol. 2000;184:373-9 pubmed
    ..We conclude that synectin is involved in syndecan-4-dependent interactions and may play a role in the assembly of syndecan-4 signaling complex. ..
  9. Keum E, Kim Y, Kim J, Kwon S, Lim Y, Han I, et al. Syndecan-4 regulates localization, activity and stability of protein kinase C-alpha. Biochem J. 2004;378:1007-14 pubmed
    ..Taken together, these results suggest that syndecan-4 interacts with PKC-alpha in vivo and regulates its localization, activity and stability. ..

More Information

Publications143 found, 100 shown here

  1. Rauch B, Millette E, Kenagy R, Daum G, Fischer J, Clowes A. Syndecan-4 is required for thrombin-induced migration and proliferation in human vascular smooth muscle cells. J Biol Chem. 2005;280:17507-11 pubmed
    ..We conclude that thrombin-released bFGF binds to syndecan-4 and FGFR-1, which is required for thrombin-induced mitogenesis and migration. ..
  2. de Parseval A, Bobardt M, Chatterji A, Chatterji U, Elder J, David G, et al. A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs. J Biol Chem. 2005;280:39493-504 pubmed
  3. Baba F, Swartz K, van Buren R, Eickhoff J, Zhang Y, Wolberg W, et al. Syndecan-1 and syndecan-4 are overexpressed in an estrogen receptor-negative, highly proliferative breast carcinoma subtype. Breast Cancer Res Treat. 2006;98:91-8 pubmed
    ..Furthermore, the close correlation between syndecan expression and negative ER status raises the possibility of hormonal regulation or more likely an association with an aggressive, ER-negative carcinoma phenotype. ..
  4. Charni F, Friand V, Haddad O, Hlawaty H, Martin L, Vassy R, et al. Syndecan-1 and syndecan-4 are involved in RANTES/CCL5-induced migration and invasion of human hepatoma cells. Biochim Biophys Acta. 2009;1790:1314-26 pubmed publisher
    ..The modulation of RANTES/CCL5-mediated cellular effects by targeting the chemokine-syndecan interaction could represent a new therapeutic approach for hepatocellular carcinoma. ..
  5. Carvallo L, Muñoz R, Bustos F, Escobedo N, Carrasco H, Olivares G, et al. Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4. J Biol Chem. 2010;285:29546-55 pubmed publisher
    ..Integrins and Syndecan4 (SDC4) are the main cell adhesion receptors involved in focal adhesion formation and are required for cell migration...
  6. Strand M, Herum K, Rana Z, Skrbic B, Askevold E, Dahl C, et al. Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart. FEBS J. 2013;280:2228-47 pubmed publisher
    ..Conclusively, our data suggest that syndecan-4 plays an important role in the immune response of the heart to increased pressure, influencing cardiac remodeling and failure progression. ..
  7. Lim S, Longley R, Couchman J, Woods A. Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha. J Biol Chem. 2003;278:13795-802 pubmed
    ..The data support a mechanism where syndecan-4 binds PKC alpha and localizes it to focal adhesions, whose assembly may be regulated by the kinase. ..
  8. Brule S, Friand V, Sutton A, Baleux F, Gattegno L, Charnaux N. Glycosaminoglycans and syndecan-4 are involved in SDF-1/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells. Biochim Biophys Acta. 2009;1790:1643-50 pubmed publisher
    ..These data suggest that targeting the glycosaminoglycan/chemokine interaction could be a new therapeutic approach for carcinomas in which SDF-1/CXCL12 is involved. ..
  9. O Connell M, Fiori J, Kershner E, Frank B, Indig F, Taub D, et al. Heparan sulfate proteoglycan modulation of Wnt5A signal transduction in metastatic melanoma cells. J Biol Chem. 2009;284:28704-12 pubmed publisher
    ..Specifically, syndecan 1 and syndecan 4 expression correlated to Wnt5A expression and melanoma malignancy...
  10. Lendorf M, Manon Jensen T, Kronqvist P, Multhaupt H, Couchman J. Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma. J Histochem Cytochem. 2011;59:615-29 pubmed publisher
    ..These syndecans may, therefore, have distinct roles in regulating breast carcinoma cell behavior. ..
  11. Finsen A, Lunde I, Sjaastad I, Østli E, Lyngra M, Jarstadmarken H, et al. Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway. PLoS ONE. 2011;6:e28302 pubmed publisher
    ..Thus, our data suggest that manipulation of syndecan-4 may provide an option for therapeutic modulation of calcineurin-NFAT signaling. ..
  12. Ohkawara B, Glinka A, Niehrs C. Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis. Dev Cell. 2011;20:303-14 pubmed publisher
    ..Here, we show that Rspo3 binds syndecan 4 (Sdc4) and that together they activate Wnt/PCP signaling...
  13. Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro I, et al. Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. J Biol Chem. 2015;290:7195-207 pubmed publisher
    ..of TNF-α; silencing of PHD2 significantly decreased TNF-α-induced expression of catabolic markers including SDC4, MMP-3, MMP-13, and ADAMTS5, as well as several inflammatory cytokines and chemokines, while partially restoring ..
  14. Nititham J, Gupta R, Zeng X, Hartogensis W, Nixon D, Deeks S, et al. Psoriasis risk SNPs and their association with HIV-1 control. Hum Immunol. 2017;78:179-184 pubmed publisher
    ..A number of genetic variants outside the MHC (SOX5, TLR9, SDC4, PROX1, IL12B, TLR4, MBL-2, TYK2, IFIH1) demonstrated nominal significance...
  15. Lipphardt M, Song J, Ratliff B, Dihazi H, Müller G, Goligorsky M. ENDOTHELIAL DYSFUNCTION IS A SUPER-INDUCER OF SYNDECAN 4: fibrogenic role of its ectodomain. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00548.2017 pubmed publisher
    b>Syndecan 4 (Synd4) is a member of membrane-spanning, glycocalyx-forming proteoglycan family. It has been suggested that Synd4 participates in renal fibrosis...
  16. Johns S, Yin X, Jeltsch M, Bishop J, Schuksz M, El Ghazal R, et al. Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis. Circ Res. 2016;119:210-21 pubmed publisher
    ..heparan sulfate proteoglycan in mouse lymphatic endothelia, and pathological lymphangiogenesis was impaired in Sdc4((-/-)) mice...
  17. Pan H, Strickland A, Madhu V, Johnson Z, Chand S, Brody J, et al. RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells. Matrix Biol. 2019;77:23-40 pubmed publisher
    ..revealed that important extracellular matrix-related genes including several collagens, MMPs, aggrecan, Tgf-β3 and Sdc4 were regulated by HuR...
  18. Rusnati M, Tulipano G, Spillmann D, Tanghetti E, Oreste P, Zoppetti G, et al. Multiple interactions of HIV-I Tat protein with size-defined heparin oligosaccharides. J Biol Chem. 1999;274:28198-205 pubmed
    ..The possibility of establishing multiple interactions increases the affinity of large heparin fragments for Tat protein and the capacity of the glycosaminoglycan to modulate the biological activity of extracellular Tat. ..
  19. Greene D, Tumova S, Couchman J, Woods A. Syndecan-4 associates with alpha-actinin. J Biol Chem. 2003;278:7617-23 pubmed
    ..We now demonstrate by Triton X-100 extraction immunoprecipitation and in vitro binding assays that the focal adhesion component alpha-actinin interacts with syndecan-4 in a beta-integrin-independent manner. ..
  20. Xie Z, Khair M, Shaukat I, Netter P, Mainard D, Barre L, et al. Non-canonical Wnt induces chondrocyte de-differentiation through Frizzled 6 and DVL-2/B-raf/CaMKII?/syndecan 4 axis. Cell Death Differ. 2018;25:1442-1456 pubmed publisher
    ..We show that in response to Wnt-3a, Frizzled 6 (Fz-6) triggers the docking of CaMKII? to syndecan 4 (SYND4) and that of B-raf to DVL-2, leading to the phosphorylation of B-raf by CaMKII? and activation of ..
  21. Hakansson S, Jacobs A, Caffrey M. Heparin binding by the HIV-1 tat protein transduction domain. Protein Sci. 2001;10:2138-9 pubmed
    ..We suggest that the heparin-binding properties of PTD-tat can be exploited for purification of PTD-tat fusions in the absence of affinity tags. ..
  22. Marzioni D, Lorenzi T, Mazzucchelli R, Capparuccia L, Morroni M, Fiorini R, et al. Expression of basic fibroblast growth factor, its receptors and syndecans in bladder cancer. Int J Immunopathol Pharmacol. 2009;22:627-38 pubmed
    ..In conclusion, our data report that the bFGF, FGFR and syndecan expressions are altered in bladder tumours. ..
  23. Kim E, Roshanravan H, Dryer S. Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling. Biochim Biophys Acta. 2015;1853:2610-20 pubmed publisher
    PodocyteTRPC6 channels have been implicated in glomerular diseases. Syndecan-4 (Sdc4) is a membrane proteoglycan that can be cleaved to release a soluble ectodomain capable of paracrine and autocrine signaling...
  24. Nagy N, Németh I, Szabad G, Szolnoky G, Belso N, Bata Csorgo Z, et al. The altered expression of syndecan 4 in the uninvolved skin of venous leg ulcer patients may predispose to venous leg ulcer. Wound Repair Regen. 2008;16:495-502 pubmed publisher
    b>Syndecan 4 (SDC4), a heparan sulfate proteoglycan, and neuropilin 1 (NRP1), a transmembrane receptor, are both involved in normal wound healing, but little is known about their possible role in venous leg ulcer pathogenesis...
  25. Brusilovsky M, Radinsky O, Cohen L, Yossef R, Shemesh A, Braiman A, et al. Regulation of natural cytotoxicity receptors by heparan sulfate proteoglycans in -cis: A lesson from NKp44. Eur J Immunol. 2015;45:1180-91 pubmed publisher
    ..The intimate interaction of NKp44 and the NK cell-associated HSPG syndecan-4 (SDC4) in -cis can directly regulate membrane distribution of NKp44 and constitutively dampens the triggering of the ..
  26. Bielecka Dabrowa A, Sakowicz A, Misztal M, von Haehling S, Ahmed A, Pietrucha T, et al. Differences in biochemical and genetic biomarkers in patients with heart failure of various etiologies. Int J Cardiol. 2016;221:1073-80 pubmed publisher
    ..In multivariate analysis TGF beta 1 (p=0.001) and syndecan 4 (p=0.001) were the only factors distinguishing HFrEF pts with DCM vs HFpEF and also TGF beta 1 (p=0...
  27. Umehara T, Murase T, Abe Y, Yamashita H, Shibaike Y, Kagawa S, et al. Identification of potential markers of fatal hypothermia by a body temperature-dependent gene expression assay. Int J Legal Med. 2019;133:335-345 pubmed publisher
    ..AP-1 transcription factor subunit (Junb), nuclear receptor subfamily 4, group A, member 1 (Nr4a1), and Syndecan 4 (Sdc4)] and the level of one protein (CTGF) were induced only by severe hypothermia...
  28. Furini G, Verderio E. Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction. Med Sci (Basel). 2019;7: pubmed publisher
    Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease...
  29. Wang J, Markova D, Anderson D, Zheng Z, Shapiro I, Risbud M. TNF-? and IL-1? promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. J Biol Chem. 2011;286:39738-49 pubmed publisher
    ..The goal of the investigation was to study if TNF-? and IL-1? regulate syndecan-4 (SDC4) expression, and if SDC4 was responsible for promoting aggrecan degradation through controlling ADAMTS activity in ..
  30. Polte T, Petzold S, Bertrand J, Schütze N, Hinz D, Simon J, et al. Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation. Nat Commun. 2015;6:7554 pubmed publisher
    Syndecan-4 (SDC4), expressed on dendritic cells (DCs) and activated T cells, plays a crucial role in DC motility and has been shown as a potential target for activated T-cell-driven diseases...
  31. Chelariu Raicu A, Wilke C, Brand M, Starzinski Powitz A, Kiesel L, Schuring A, et al. Syndecan-4 expression is upregulated in endometriosis and contributes to an invasive phenotype. Fertil Steril. 2016;106:378-85 pubmed publisher
    ..To study the expression and function of syndecan-4 in endometriosis...
  32. Zhao Y, Ding C, Xue W, Ding X, Zheng J, Gao Y, et al. Genome-wide DNA methylation analysis in renal ischemia reperfusion injury. Gene. 2017;610:32-43 pubmed publisher
    ..methylation status and expression of five out of the 18 genes, including 2700049A03Rik, Ccr9, Fgd2, Pfkfb3, and Sdc4 in an independent renal tissue cohort...
  33. Hamon M, Mbemba E, Charnaux N, Slimani H, Brule S, Saffar L, et al. A syndecan-4/CXCR4 complex expressed on human primary lymphocytes and macrophages and HeLa cell line binds the CXC chemokine stromal cell-derived factor-1 (SDF-1). Glycobiology. 2004;14:311-23 pubmed
    ..This syndecan-4/CXCR4 complex is likely a functional unit involved in SDF-1 binding. The role of these interactions in the pathophysiology of SDF-1 deserves further study. ..
  34. Ramnath R, Foster R, Qiu Y, Cope G, Butler M, Salmon A, et al. Matrix metalloproteinase 9-mediated shedding of syndecan 4 in response to tumor necrosis factor α: a contributor to endothelial cell glycocalyx dysfunction. FASEB J. 2014;28:4686-99 pubmed publisher
    ..TNF-α induced syndecan 4 (SDC4) mRNA up-regulation by 2...
  35. Roskoski R. ROS1 protein-tyrosine kinase inhibitors in the treatment of ROS1 fusion protein-driven non-small cell lung cancers. Pharmacol Res. 2017;121:202-212 pubmed publisher
    ..The ROS1 fusion partners include CD74, CCDC6, EZR, FIG, KDELR2, LRIG3, MSN, SDC4, SLC34A2, TMEM106B, TMP3, and TPD52L1...
  36. Thilo F, Lee M, Xia S, Zakrzewicz A, Tepel M. High glucose modifies transient receptor potential canonical type 6 channels via increased oxidative stress and syndecan-4 in human podocytes. Biochem Biophys Res Commun. 2014;450:312-7 pubmed publisher
    ..6 mmol/L D-glucose increased ROS to 2.49±0.09 (p<0.001) only. The increase in ROS was inhibited by tempol and by SDC-4 knockdown. High glucose modifies TRPC6 channels and ROS production via SDC-4 in human podocytes. ..
  37. Lussier J, Diouf M, Lévesque V, Sirois J, Ndiaye K. Gene expression profiling of upregulated mRNAs in granulosa cells of bovine ovulatory follicles following stimulation with hCG. Reprod Biol Endocrinol. 2017;15:88 pubmed publisher
  38. Oikari L, Okolicsanyi R, Qin A, Yu C, Griffiths L, Haupt L. Cell surface heparan sulfate proteoglycans as novel markers of human neural stem cell fate determination. Stem Cell Res. 2016;16:92-104 pubmed publisher
    ..Furthermore, neuronal differentiation of the cells upregulated SDC4, GPC1, GPC2, GPC3 and GPC6 expression with increased GPC4 expression observed under astrocyte culture conditions...
  39. Kaneider N, Förster E, Mosheimer B, Sturn D, Wiedermann C. Syndecan-4-dependent signaling in the inhibition of endotoxin-induced endothelial adherence of neutrophils by antithrombin. Thromb Haemost. 2003;90:1150-7 pubmed
  40. Schmidt A, Echtermeyer F, Alozie A, Brands K, Buddecke E. Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds. J Biol Chem. 2005;280:34441-6 pubmed
  41. Erdem M, Erdem S, Sanli O, Sak H, Kilicaslan I, Sahin F, et al. Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma. Urol Oncol. 2014;32:25.e13-20 pubmed publisher
    ..Given that TGM2 interaction with syndecan-4 (SDC4) on the cell surface is important in the activation of ITGB1 and integrin-mediated survival signaling, we ..
  42. Ma P, Beck S, Raab R, McKown R, Coffman G, Utani A, et al. Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin. J Cell Biol. 2006;174:1097-106 pubmed
    ..This novel example of cell specification through extracellular modification of an HS proteoglycan has broad implications in development, homeostasis, and disease. ..
  43. Whiteford J, Behrends V, Kirby H, Kusche Gullberg M, Muramatsu T, Couchman J. Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways. Exp Cell Res. 2007;313:3902-13 pubmed
    ..Evidence for an indirect interaction of beta1 integrin with both syndecan ectodomains was obtained, all of which suggests a distinct mechanism of integrin-mediated adhesion. ..
  44. Li R, Wu H, Xie J, Li G, Gu R, Kang L, et al. Syndecan-4 regulates the bFGF-induced chemotactic migration of endothelial cells. J Mol Histol. 2016;47:503-9 pubmed publisher
    ..b>Synd4 is a ubiquitous heparin sulfate proteoglycan receptor on the cell surface that has been identified to promote ..
  45. Park S, Ahn B, Lim S, Sun J, Kim H, Hong M, et al. Characteristics and Outcome of ROS1-Positive Non-Small Cell Lung Cancer Patients in Routine Clinical Practice. J Thorac Oncol. 2018;13:1373-1382 pubmed publisher
    ..0 months (range 2.1-84.1). The most common fusion partner was CD74 molecule gene (CD74), followed by syndecan 4 gene (SDC4), ezrin gene (EZR), tropomyosin 3 gene (TPM3), TRK-fused gene (TFG), zinc finger CCHC-type containing ..
  46. Kojima T, Katsumi A, Yamazaki T, Muramatsu T, Nagasaka T, Ohsumi K, et al. Human ryudocan from endothelium-like cells binds basic fibroblast growth factor, midkine, and tissue factor pathway inhibitor. J Biol Chem. 1996;271:5914-20 pubmed
    ..These findings suggest that ryudocan may possess multiple biological functions, such as bFGF modulation, neurite growth promotion, and anticoagulation, via HS-binding effectors in the cellular microenvironment. ..
  47. Wang Z, Telci D, Griffin M. Importance of syndecan-4 and syndecan -2 in osteoblast cell adhesion and survival mediated by a tissue transglutaminase-fibronectin complex. Exp Cell Res. 2011;317:367-81 pubmed publisher
  48. Takagi A, Kojima T, Tsuzuki S, Katsumi A, Yamazaki T, Sugiura I, et al. Structural organization and promoter activity of the human ryudocan gene. J Biochem. 1996;119:979-84 pubmed
    ..The determination of the human ryudocan gene structure will allow elucidation of constitutive, cell-specific, tissue-specific, and developmentally regulated expression. ..
  49. Kaneider N, Egger P, Dunzendorfer S, Wiedermann C. Syndecan-4 as antithrombin receptor of human neutrophils. Biochem Biophys Res Commun. 2001;287:42-6 pubmed
    ..In the presence of pentasaccharide, antithrombin lost its activity on the cells. Data suggest that antithrombin regulates neutrophil migration via effects of its heparin-binding site on cell surface syndecan-4. ..
  50. Lin T, Lu K, Chen W, Cheng C, Lin Y. Roles of syndecan-4 and relative kinases in dorsal root ganglion neuron adhesion and mechanotransduction. Neurosci Lett. 2015;592:88-93 pubmed publisher
    ..These results indicate that SDC4-pPKCα-FAKpTyr397-pERK1/2 may play a crucial role in DRG adhesion and mechanotransduction.
  51. Wang H, Jin H, Rapraeger A. Syndecan-1 and Syndecan-4 Capture Epidermal Growth Factor Receptor Family Members and the α3β1 Integrin Via Binding Sites in Their Ectodomains: NOVEL SYNSTATINS PREVENT KINASE CAPTURE AND INHIBIT α6β4-INTEGRIN-DEPENDENT EPITHELIAL CELL MOTILITY. J Biol Chem. 2015;290:26103-13 pubmed publisher
    ..In contrast, EGFR associates with Sdc4 and the α6β4 integrin, and EGFR-dependent motility depends on cytoplasmic engagement of β4 integrin with ..
  52. Hakansson S, Caffrey M. Structural and dynamic properties of the HIV-1 tat transduction domain in the free and heparin-bound states. Biochemistry. 2003;42:8999-9006 pubmed
    ..69 in the presence of heparin). A model for the first step of TTD-mediated entry into cells is presented. ..
  53. Peterson J, Sheibani N, David G, Garcia Pardo A, Peters D. Heparin II domain of fibronectin uses alpha4beta1 integrin to control focal adhesion and stress fiber formation, independent of syndecan-4. J Biol Chem. 2005;280:6915-22 pubmed
  54. Julien M, Wang P, Haller C, Wen J, Chaikof E. Mechanical strain regulates syndecan-4 expression and shedding in smooth muscle cells through differential activation of MAP kinase signaling pathways. Am J Physiol Cell Physiol. 2007;292:C517-25 pubmed
  55. Cheng H, Ye L, Xue L. [Detection of ROS1 gene rearrangement by FISH and analysis of its clinical features in non-small cell lung cancer patients]. Zhonghua Zhong Liu Za Zhi. 2014;36:751-4 pubmed
    ..2%) from the 1 652 NSCLC tissues. Among these positive cases, 15 were CD74-ROS1, 13 were SLC34A2-ROS1, 13 were SDC4-ROS1 and 12 were TPM3-ROS1...
  56. . Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. Cell Physiol Biochem. 2015;36:1291-304 pubmed
    ..Syndecans are members of the HSPGs family and are highly expressed in various tumor cells. Syndecan-4 (SDC4) is a unique member of syndecans that activates protein kinase C alpha (PKC?)...
  57. Gharbaran R. Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs-syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin's lymphoma. Tumour Biol. 2016;37:11573-11588 pubmed
    ..In classical Hodgkin's lymphoma (cHL), a lymphoid neoplasm of predominantly B cell origin, SDC1 and SDC4 are the active SDCs, and a number of GF (vascular endothelial growth factor, fibroblast growth factor, etc...
  58. Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, et al. Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages. Biochim Biophys Acta. 2003;1617:80-8 pubmed
    ..The role of these interactions in the pathophysiology of RANTES deserves further study. ..
  59. Vivès R, Imberty A, Sattentau Q, Lortat Jacob H. Heparan sulfate targets the HIV-1 envelope glycoprotein gp120 coreceptor binding site. J Biol Chem. 2005;280:21353-7 pubmed
  60. Binley J, Ngo Abdalla S, Moore P, Bobardt M, Chatterji U, Gallay P, et al. Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120. Retrovirology. 2006;3:39 pubmed
  61. Okina E, Manon Jensen T, Whiteford J, Couchman J. Syndecan proteoglycan contributions to cytoskeletal organization and contractility. Scand J Med Sci Sports. 2009;19:479-89 pubmed publisher
    ..These processes are described here, their significance being potential roles in wound contraction, tumor-stroma interactions, fibrosis and the regulation of motility. ..
  62. Okolicsanyi R, Buffiere A, Jacinto J, Chacon Cortes D, Chambers S, Youl P, et al. Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population. Tumour Biol. 2015;36:1731-8 pubmed publisher
    ..levels of syndecan-1 (SDC1) have been demonstrated in more invasive breast tumours while elevated syndecan-4 (SDC4) levels have been identified to correspond with improved prognosis...
  63. Xie J, Li R, Wu H, Chen J, Li G, Chen Q, et al. Advanced Glycation Endproducts Impair Endothelial Progenitor Cell Migration and Homing via Syndecan 4 Shedding. Stem Cells. 2017;35:522-531 pubmed publisher
    ..Syndecan-4 (synd4) is a ubiquitous heparan sulfate proteoglycan receptor on the cell surface, involved in SDF-1-dependent cell ..
  64. Smith M, Novotny J, Carl V, Comeau L. Helicobacter pylori and toll-like receptor agonists induce syndecan-4 expression in an NF-kappaB-dependent manner. Glycobiology. 2006;16:221-9 pubmed
    ..pylori and TLR agonists. These results thus demonstrate that the response of the syndecan-4 gene to infectious agents, or their products, is a direct result of NF-kappaB binding to the promoter and induction of de novo transcription. ..
  65. Wang Z, Collighan R, Gross S, Danen E, Orend G, Telci D, et al. RGD-independent cell adhesion via a tissue transglutaminase-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 ?5?1 integrin co-signaling. J Biol Chem. 2010;285:40212-29 pubmed publisher
  66. Tan X, Khalil N, Tesarik C, Vanapalli K, Yaputra V, Alkhouri H, et al. Th1 cytokine-induced syndecan-4 shedding by airway smooth muscle cells is dependent on mitogen-activated protein kinases. Am J Physiol Lung Cell Mol Physiol. 2012;302:L700-10 pubmed publisher
    ..ASMC syndecan-4 production during Th1 inflammatory conditions may regulate chemokine activity and mast cell recruitment to the ASM in asthma. ..
  67. Fujita N, Hirose Y, Tran C, Chiba K, Miyamoto T, Toyama Y, et al. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells. FASEB J. 2014;28:2455-65 pubmed publisher
    Intervertebral disc degeneration is the leading cause of chronic back pain. Recent studies show that raised level of SDC4, a cell-surface heparan sulfate (HS) proteoglycan, plays a role in pathogenesis of disc degeneration...
  68. Binch A, Shapiro I, Risbud M. Syndecan-4 in intervertebral disc and cartilage: Saint or synner?. Matrix Biol. 2016;52-54:355-362 pubmed publisher
    ..Within these skeletal tissues a small, cell surface heparan sulphate proteoglycan; syndecan-4 (SDC4) has been implicated in maintaining physiological functions...
  69. Dews I, MacKenzie K. Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions. Proc Natl Acad Sci U S A. 2007;104:20782-7 pubmed
  70. Corti F, Finetti F, Ziche M, Simons M. The syndecan-4/protein kinase C? pathway mediates prostaglandin E2-induced extracellular regulated kinase (ERK) activation in endothelial cells and angiogenesis in vivo. J Biol Chem. 2013;288:12712-21 pubmed publisher
    ..We show that in the absence of proteoglycan syndecan-4 (Sdc4), PGE2-induced ERK activation is decreased significantly, as is endothelial cell migration and cord formation in a ..
  71. Wang H, Jin H, Beauvais D, Rapraeger A. Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival. J Biol Chem. 2014;289:30318-32 pubmed publisher
    ..on a complex consisting of human epidermal growth factor receptor-1 (HER1, commonly known as EGFR), α6β4, and Sdc4. The two syndecans recognize distinct sites at the extreme C terminus of the β4 integrin cytoplasmic domain...
  72. Lin W, Zhang J, Lin H, Li Z, Sun X, Xin D, et al. Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD. Nat Commun. 2016;7:11848 pubmed publisher
    ..Here we show that syndecan-4 (SDC4) is a RIG-I-interacting partner identified in a yeast two-hybrid screen...
  73. Nakao M, Sugaya M, Takahashi N, Otobe S, Nakajima R, Oka T, et al. Increased syndecan-4 expression in sera and skin of patients with atopic dermatitis. Arch Dermatol Res. 2016;308:655-660 pubmed
    ..Taken together, our study has demonstrated that SDC-4 expression was increased in sera and skin of AD patients, suggesting that SDC-4 may contribute to the development of AD. ..
  74. Keller Pinter A, Ughy B, Domoki M, Pettkó Szandtner A, Letoha T, Tovari J, et al. The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction-dependent manner. PLoS ONE. 2017;12:e0187094 pubmed publisher
    ..regulatory mechanism of Rac1 activity, which is controlled by a phosphomimetic (Ser179Glu) mutant of syndecan-4 (SDC4). SDC4 is a ubiquitously expressed transmembrane, heparan sulfate proteoglycan...
  75. David G, Van Der Schueren B, Marynen P, Cassiman J, Van den Berghe H. Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells. J Cell Biol. 1992;118:961-9 pubmed
    ..We propose to name this proteoglycan "amphiglycan" (from the Greek words amphi, "around, on both sides of" and amphoo, "both") referring ..
  76. Tkachenko E, Simons M. Clustering induces redistribution of syndecan-4 core protein into raft membrane domains. J Biol Chem. 2002;277:19946-51 pubmed
    ..We conclude that syndecan-4 clustering induces its redistribution to the non-caveolae raft compartment. This process may play an important role in syndecan-4-mediation of FGF2 signaling. ..
  77. Baeyens N, Mulligan Kehoe M, Corti F, Simon D, Ross T, Rhodes J, et al. Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling. Proc Natl Acad Sci U S A. 2014;111:17308-13 pubmed publisher
    ..We now report that in hypercholesterolemic mice, deletion of syndecan 4 (S4(-/-)) drastically increased atherosclerotic plaque burden with the appearance of plaque in normally ..
  78. Zhang Z, Rankin S, Zorn A. Syndecan4 coordinates Wnt/JNK and BMP signaling to regulate foregut progenitor development. Dev Biol. 2016;416:187-199 pubmed publisher
    ..Here we identify the transmembrane heparan sulphate proteoglycan Syndecan-4 (Sdc4), as a key regulator of both non-canonical Wnt and BMP signaling in the Xenopus foregut...
  79. Kaneider N, Reinisch C, Dunzendorfer S, Römisch J, Wiedermann C, Wiederman C. Syndecan-4 mediates antithrombin-induced chemotaxis of human peripheral blood lymphocytes and monocytes. J Cell Sci. 2002;115:227-36 pubmed
    ..Data indicate that antithrombin directly inhibits chemokine-stimulated migration of monocytes and lymphocytes via the effects of its heparin-binding site on cell surface syndecan-4 by activation of protein kinase C and Rho signaling. ..
  80. Magalhaes A, Marcos N, Carvalho A, David L, Figueiredo C, Bastos J, et al. Helicobacter pylori cag pathogenicity island-positive strains induce syndecan-4 expression in gastric epithelial cells. FEMS Immunol Med Microbiol. 2009;56:223-32 pubmed publisher
    ..The present study shows that highly pathogenic H. pylori strains induce syndecan-4 expression, both in human gastric mucosa and in gastric cell lines, in a cagPAI-dependent manner. ..
  81. Ma X, Ouyang P, Zhang Z, Lai W, Xu D. [Changes and clinical significance of serum level of syndecan-4 protein in patients with chronic congestive heart failure]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013;29:866-9 pubmed
  82. Hambruch N, Kumstel S, Haeger J, Pfarrer C. Bovine placentomal heparanase and syndecan expression is related to placental maturation. Placenta. 2017;57:42-51 pubmed publisher
    ..Heparanase expression was additionally quantified by Western blot. Heparanase, SDC1 and SDC4 displayed significant changes in expression and localization depending on gestational progress and mode of ..
  83. Pal Ghosh S, Tadvalkar G, Stepp M. Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. Invest Ophthalmol Vis Sci. 2017;58:4959-4975 pubmed publisher
    ..Quantitative PCR was performed to quantify expression of SDC1, SDC2, SDC3, and SDC4 in corneal epithelial mRNA...
  84. Furini G, Schroeder N, Huang L, Boocock D, Scarpellini A, Coveney C, et al. Proteomic Profiling Reveals the Transglutaminase-2 Externalization Pathway in Kidneys after Unilateral Ureteric Obstruction. J Am Soc Nephrol. 2018;29:880-905 pubmed publisher
    ..Knockout of syndecan-4 (SDC4) greatly impaired TG2 exosomal secretion. TG2 coprecipitated with SDC4 from exosome lysate but not ectosome lysate...
  85. Bhatt A, Erdjument Bromage H, Tempst P, Craik C, Moasser M. Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene. 2005;24:5333-43 pubmed
    ..This suggests a potential pathway by which hyperactive src kinases in tumors can deregulate adhesion signaling and mediate the metastatic phenotype. ..
  86. Elfenbein A, Lanahan A, Zhou T, Yamasaki A, Tkachenko E, Matsuda M, et al. Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis. Sci Signal. 2012;5:ra36 pubmed publisher
    ..receptors: receptor tyrosine kinases, such as FGF receptor 1 (FGFR1), and heparan sulfate proteoglycans, such as syndecan 4 (S4). We examined the distinct contributions of FGFR1 and S4 in shaping the endothelial response to FGF2...
  87. Rose G, Crocco P, De Rango F, Corsonello A, Lattanzio F, De Luca M, et al. Metabolism and successful aging: Polymorphic variation of syndecan-4 (SDC4) gene associate with longevity and lipid profile in healthy elderly Italian subjects. Mech Ageing Dev. 2015;150:27-33 pubmed publisher
    ..In this frame, a genetic variant (rs1981429) in the SDC4 gene encoding for syndecan-4, a central mediator of cell adhesion, has been associated with body composition in ..
  88. Zimmermann N, Saiga H, Houthuys E, Moura Alves P, Koehler A, Bandermann S, et al. Syndecans promote mycobacterial internalization by lung epithelial cells. Cell Microbiol. 2016;18:1846-1856 pubmed publisher
    ..We identified syndecan 4 (Sdc4) as mycobacterial attachment receptor on alveolar epithelial cells...
  89. Wang L, Collings C, Zhao Z, Cozzolino K, Ma Q, Liang K, et al. A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism. Genes Dev. 2017;31:2056-2066 pubmed publisher
    ..genes modulating fatty acid metabolism, including ADIPOR1 (adiponectin receptor 1), COX7C, SDC4, and COQ7 Our detailed molecular studies identify ADIPOR1 signaling, which is inactivated in both ..
  90. Ghez D, Lepelletier Y, Jones K, Pique C, Hermine O. Current concepts regarding the HTLV-1 receptor complex. Retrovirology. 2010;7:99 pubmed publisher
    ..In light of the most recent data, we propose a model of the HTLV-1 receptor complex and discuss its potential impact on HTLV-1 infection. ..
  91. Carulli S, Beck K, Dayan G, Boulesteix S, Lortat Jacob H, Rousselle P. Cell surface proteoglycans syndecan-1 and -4 bind overlapping but distinct sites in laminin ?3 LG45 protein domain. J Biol Chem. 2012;287:12204-16 pubmed publisher
    ..These results suggest that LG45 may trigger different signals toward keratinocytes depending on its interaction with syndecan-1 or -4. ..