Gene Symbol: SCOT
Description: 3-oxoacid CoA-transferase 1
Alias: OXCT, SCOT, succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial, 3-oxoacid CoA transferase, SCOT-s, somatic-type succinyl-CoA:3-oxoacid CoA-transferase, succinyl CoA:3-oxoacid CoA transferase, succinyl-CoA:3-ketoacid-CoA transferase
Species: human
Products:     SCOT

Top Publications

  1. Tanaka H, Kohroki J, Iguchi N, Onishi M, Nishimune Y. Cloning and characterization of a human orthologue of testis-specific succinyl CoA: 3-oxo acid CoA transferase (Scot-t) cDNA. Mol Hum Reprod. 2002;8:16-23 pubmed
    Succinyl CoA: 3-oxo acid CoA transferase (scot; EC is a key enzyme for metabolism of ketone bodies...
  2. Fukao T, Kursula P, Owen E, Kondo N. Identification and characterization of a temperature-sensitive R268H mutation in the human succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene. Mol Genet Metab. 2007;92:216-21 pubmed
    Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency causes episodic ketoacidosis. We encountered a case of siblings in South Africa in whom a novel homozygous mutation (R268H) was found in genomic DNA...
  3. Fukao T, Sass J, Kursula P, Thimm E, Wendel U, Ficicioglu C, et al. Clinical and molecular characterization of five patients with succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency. Biochim Biophys Acta. 2011;1812:619-24 pubmed publisher
    Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency is an inborn error of ketone body metabolism and causes episodic ketoacidosis. We report clinical and molecular analyses of 5 patients with SCOT deficiency...
  4. Kassovska Bratinova S, Fukao T, Song X, Duncan A, Chen H, Robert M, et al. Succinyl CoA: 3-oxoacid CoA transferase (SCOT): human cDNA cloning, human chromosomal mapping to 5p13, and mutation detection in a SCOT-deficient patient. Am J Hum Genet. 1996;59:519-28 pubmed
    ..We mapped the human SCOT locus (OXCT) to the cytogenetic band 5p13 by in situ hybridization...
  5. Fukao T, Mitchell G, Song X, Nakamura H, Kassovska Bratinova S, Orii K, et al. Succinyl-CoA:3-ketoacid CoA transferase (SCOT): cloning of the human SCOT gene, tertiary structural modeling of the human SCOT monomer, and characterization of three pathogenic mutations. Genomics. 2000;68:144-51 pubmed
    The activity of succinyl-CoA:3-ketoacid CoA transferase (SCOT; locus symbol OXCT; EC is the main determinant of the ketolytic capacity of tissues. Hereditary SCOT deficiency causes episodic ketoacidosis...
  6. Fukao T, Song X, Mitchell G, Yamaguchi S, Sukegawa K, Orii T, et al. Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases. Pediatr Res. 1997;42:498-502 pubmed
    ..distribution in human tissues of three enzymes of ketone body utilization: succinyl-CoA:3-ketoacid CoA transferase (SCOT), mitochondrial acetoacetyl-CoA thiolase (T2), and cytosolic acetoacetyl-CoA thiolase (CT)...
  7. Song X, Fukao T, Watanabe H, Shintaku H, Hirayama K, Kassovska Bratinova S, et al. Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency: two pathogenic mutations, V133E and C456F, in Japanese siblings. Hum Mutat. 1998;12:83-8 pubmed
    Succinyl-CoA:3-ketoacid CoA transferase (SCOT; EC; locus symbol OXCT) is the key enzyme of ketone body utilization. Hereditary SCOT deficiency (MIM 245050) causes episodes of severe ketoacidosis...
  8. Fukao T, Shintaku H, Kusubae R, Zhang G, Nakamura K, Kondo M, et al. Patients homozygous for the T435N mutation of succinyl-CoA:3-ketoacid CoA Transferase (SCOT) do not show permanent ketosis. Pediatr Res. 2004;56:858-63 pubmed
    Succinyl-CoA:3-ketoacid CoA transferase (SCOT; locus symbol OXCT; E.C. is the main determinant of the ketolytic capacity of tissues. Hereditary SCOT deficiency causes episodic ketoacidosis...
  9. Zeng J, Zhou S, Zhao J, Jin M, Kang D, Yang Y, et al. Role of OXCT1 in ovine adipose and preadipocyte differentiation. Biochem Biophys Res Commun. 2019;512:779-785 pubmed publisher
    ..OXCT1 knockdown in ovine adipocytes promoted lipid accumulation, whereas overexpression did the converse. This study demonstrates that OXCT1 may play a role in adipogenesis and provides new insight on adipose deposition in sheep. ..

More Information


  1. Dreisbach J, Nicol E, Roobottom C, Padley S, Roditi G. Challenges in delivering computed tomography coronary angiography as the first-line test for stable chest pain. Heart. 2018;104:921-927 pubmed publisher
    ..percutaneous coronary interventions performed for stable angina in the NHS in 2015 was applied to a model based on SCOT-HEART (CTCA in patients with suspected angina due to coronary heart disease: an open-label, parallel-group, ..
  2. Xu Y, Shen S, Chen W, Chen L. Analysis of Genetic Diversity and Development of a SCAR Marker for Green Tea (Camellia sinensis) Cultivars in Zhejiang Province: The Most Famous Green Tea-Producing Area in China. Biochem Genet. 2019;: pubmed publisher
    ..tea cultivars in Zhejiang Province-the most famous green tea-producing area of China-using start codon-targeted (SCoT) markers and to develop a specific sequence-characterized amplified region (SCAR) marker for application in ..
  3. Zhang M, Xu H, Wang Y, Shi Z, Zhang N. Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013;69:1089-93 pubmed publisher
    Succinyl-CoA:3-ketoacid CoA transferase (SCOT) plays a crucial role in ketone-body metabolism. SCOT from Drosophila melanogaster (DmSCOT) was purified and crystallized. The crystal structure of DmSCOT was determined at 2...
  4. Hasan N, Longacre M, Seed Ahmed M, Kendrick M, Gu H, Ostenson C, et al. Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells. Arch Biochem Biophys. 2010;499:62-8 pubmed publisher
    Succinyl-CoA:3-ketoacid-CoA transferase (SCOT) is a mitochondrial enzyme that catalyzes the reversible transfer of coenzyme-A from acetoacetyl-CoA to succinate to form acetoacetate and succinyl-CoA...
  5. Robles Zurita J, Boyd K, Briggs A, Iveson T, Kerr R, Saunders M, et al. SCOT: a comparison of cost-effectiveness from a large randomised phase III trial of two durations of adjuvant Oxaliplatin combination chemotherapy for colorectal cancer. Br J Cancer. 2018;119:1332-1338 pubmed publisher
    The Short Course Oncology Therapy (SCOT) study is an international, multicentre, non-inferiority randomised controlled trial assessing the efficacy, toxicity, and cost-effectiveness of 3 months (3 M) versus the usually given 6 months (6..
  6. Williams M, Moss A, Dweck M, Adamson P, Alam S, Hunter A, et al. Coronary Artery Plaque Characteristics Associated With Adverse Outcomes in the SCOT-HEART Study. J Am Coll Cardiol. 2019;73:291-301 pubmed publisher
    ..In this SCOT-HEART (Scottish COmputed Tomography of the HEART Trial) post hoc analysis, the presence of adverse plaque (positive ..
  7. Cotter D, d Avignon D, Wentz A, Weber M, Crawford P. Obligate role for ketone body oxidation in neonatal metabolic homeostasis. J Biol Chem. 2011;286:6902-10 pubmed publisher
    ..Here, we use novel Oxct1(-/-) mice, which lack the ketolytic enzyme succinyl-CoA:3-oxo-acid CoA-transferase (SCOT), to demonstrate that ketone body oxidation is required for postnatal survival in mice...
  8. Puchalska P, Martin S, Huang X, Lengfeld J, Dániel B, Graham M, et al. Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis. Cell Metab. 2019;29:383-398.e7 pubmed publisher
    ..only ∼15% of them, the vast majority required the mitochondrial enzyme succinyl-coenzyme A-oxoacid transferase (SCOT)...
  9. Shekhawat J, Rai M, Shekhawat N, Kataria V. Exploring genetic variability in Prosopis cineraria using two gene targeted CAAT box-derived polymorphism (CBDP) and start codon targeted (SCoT) polymorphism markers. Mol Biol Rep. 2018;45:2359-2367 pubmed publisher
    Two gene targeted molecular marker systems, CAAT box-derived polymorphism (CBDP) and start codon targeted (SCoT) polymorphism, were used to assess the genetic diversity and relatedness in Prosopis cineraria, a tree of abiotic stress ..
  10. Jennings C, MacDonald T, Wei L, Brown M, McConnachie L, Mackenzie I. Does offering an incentive payment improve recruitment to clinical trials and increase the proportion of socially deprived and elderly participants?. Trials. 2015;16:80 pubmed publisher
    ..A total of 1,015 potential patients for five clinical trials (SCOT, FAST and PATHWAY 1, 2 and 3) were randomised to receive either a standard trial invitation letter or a trial ..
  11. Kapilashrami A, Marsden S. Examining intersectional inequalities in access to health (enabling) resources in disadvantaged communities in Scotland: advancing the participatory paradigm. Int J Equity Health. 2018;17:83 pubmed publisher
    ..See )...
  12. Zeng B, Yan H, Huang L, Wang Y, Wu J, Huang X, et al. Orthogonal design in the optimization of a start codon targeted (SCoT) PCR system in Roegneria kamoji Ohwi. Genet Mol Res. 2016;15: pubmed publisher
    ..However, the start codon targeted (SCoT) polymorphism has not been conducted on R. kamoji...
  13. Alikhani L, Rahmani M, Shabanian N, Badakhshan H, Khadivi Khub A. Genetic variability and structure of Quercus brantii assessed by ISSR, IRAP and SCoT markers. Gene. 2014;552:176-83 pubmed publisher
    ..Three molecular marker techniques: start codon targeted (SCoT), inter-simple sequence repeat (ISSR) and inter-retrotransposon amplified polymorphism (IRAP) markers were compared ..
  14. Ahmed H, Qureshi O, Khan A. Reviving a ghost in the history of technology: the social construction of the recumbent bicycle. Soc Stud Sci. 2015;45:130-6 pubmed
    ..and social perspectives that led to the rejection of the recumbent bicycle by utilizing the theory of Social Construction of Technology (SCOT) and Bijker's two power theory, providing a contrast with the adoption of the safety bicycle.
  15. McGowan R, Tydeman G, Shapiro D, Craig T, Morrison N, Logan S, et al. DNA copy number variations are important in the complex genetic architecture of müllerian disorders. Fertil Steril. 2015;103:1021-1030.e1 pubmed publisher
  16. Rafizadeh A, Koohi Dehkordi M, Sorkheh K. Molecular insights of genetic variation in milk thistle (Silybum marianum [L.] Gaertn.) populations collected from southwest Iran. Mol Biol Rep. 2018;45:601-609 pubmed publisher
    Milk thistle (Silybum marianum) is among the world's popular medicinal plants. Start Codon Targeted (SCoT) marker system was utilized to investigate the genetic variability of 80 S. marianum genotypes from eight populations in Iran...
  17. Jiao J, Jia X, Liu P, Zhang Q, Liu F, Ma C, et al. Species identification of polygonati rhizoma in China by both morphological and molecular marker methods. C R Biol. 2018;341:102-110 pubmed publisher
    ..markers as well as two types of molecular markers, inter-sample sequence repeat (ISSR) and start codon targeted (SCoT) are suitable for species identification of the polygonati rhizoma germplasms...
  18. Schugar R, Moll A, André d Avignon D, Weinheimer C, Kovacs A, Crawford P. Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling. Mol Metab. 2014;3:754-69 pubmed publisher
    ..mice that lack the enzyme required for terminal oxidation of ketone bodies, succinyl-CoA:3-oxoacid CoA transferase (SCOT) to determine the role of ketone body oxidation in the myocardial injury response...
  19. Gołowicz D, Urbańczyk M, Shchukina A, Kazimierczuk K. SCoT: Swept coherence transfer for quantitative heteronuclear 2D NMR. J Magn Reson. 2018;294:1-6 pubmed publisher
    ..We demonstrate the concept for the coherence transfer and multiplicity-edit delays in a heteronuclear single-quantum correlation experiment (HSQC). ..
  20. Iveson T, Kerr R, Saunders M, Cassidy J, Holländer N, Tabernero J, et al. 3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial. Lancet Oncol. 2018;19:562-578 pubmed publisher
    ..The SCOT study was an international, randomised, phase 3, non-inferiority trial done at 244 centres...
  21. Adamson P, Newby D, Hill C, Coles A, Douglas P, Fordyce C. Comparison of International Guidelines for Assessment of Suspected Stable Angina: Insights From the PROMISE and SCOT-HEART. JACC Cardiovasc Imaging. 2018;11:1301-1310 pubmed publisher were obtained from the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) and SCOT-HEART (Scottish Computed Tomography of the Heart) trials...
  22. Tian H, Han L, Zhang J, Li X, Kawahara T, Yukawa T, et al. Genetic diversity in the endangered terrestrial orchid Cypripedium japonicum in East Asia: Insights into population history and implications for conservation. Sci Rep. 2018;8:6467 pubmed publisher
    ..japonicum in China maintains the highest genetic variation among the three countries. Using ISSR and SCoT markers, we investigated genetic diversity in 17 populations to test the three hypotheses...
  23. Luis S, Lima M, Roseta Palma C, Rodrigues N, P Sousa L, Freitas F, et al. Psychosocial drivers for change: Understanding and promoting stakeholder engagement in local adaptation to climate change in three European Mediterranean case studies. J Environ Manage. 2018;223:165-174 pubmed publisher
    ..Study 1, stakeholders from three European Mediterranean case studies were surveyed: Baixo Vouga Lagunar (Portugal), SCOT Provence Méditerranée (France), and the island of Crete (Greece) (N = 115)...
  24. Sullivan K, Majhail N, Bredeson C, Carpenter P, Chatterjee S, Crofford L, et al. Systemic Sclerosis as an Indication for Autologous Hematopoietic Cell Transplantation: Position Statement from the American Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2018;24:1961-1964 pubmed publisher
    ..Transplant centers in the United States are strongly encouraged to report patient and outcomes data to the Center for International Blood and Marrow Transplant Research on their patients receiving AHCT for this indication. ..
  25. Tiezzi F, Parker Gaddis K, Cole J, Clay J, Maltecca C. A genome-wide association study for clinical mastitis in first parity US Holstein cows using single-step approach and genomic matrix re-weighting procedure. PLoS ONE. 2015;10:e0114919 pubmed publisher
    ..Despite the lack of information in this study, candidate QTL for CM were identified in the US Holstein population. ..
  26. Feng S, He R, Yang S, Chen Z, Jiang M, Lu J, et al. Start codon targeted (SCoT) and target region amplification polymorphism (TRAP) for evaluating the genetic relationship of Dendrobium species. Gene. 2015;567:182-8 pubmed publisher
    Two molecular marker systems, start codon targeted (SCoT) and target region amplification polymorphism (TRAP), were used for genetic relationship analysis of 36 Dendrobium species collected from China...
  27. Guo Z, Fu K, Zhang X, Bai S, Fan Y, Peng Y, et al. Molecular insights into the genetic diversity of Hemarthria compressa germplasm collections native to southwest China. Molecules. 2014;19:21541-59 pubmed publisher
    Start codon targeted polymorphism (SCoT) analysis was employed to distinguish 37 whipgrass (Hemarthria compressa L.) clones and assess the genetic diversity and population structure among these genotypes...
  28. Baskaran L, Danad I, Gransar H, ó Hartaigh B, Schulman Marcus J, Lin F, et al. A Comparison of the Updated Diamond-Forrester, CAD Consortium, and CONFIRM History-Based Risk Scores for Predicting Obstructive Coronary Artery Disease in Patients With Stable Chest Pain: The SCOT-HEART Coronary CTA Cohort. JACC Cardiovasc Imaging. 2018;: pubmed publisher
    ..risk scores in predicting obstructive coronary artery disease (CAD) among patients with stable chest pain from the SCOT-HEART study...
  29. Zhang J, Xie W, Wang Y, Zhao X. Potential of Start Codon Targeted (SCoT) markers to estimate genetic diversity and relationships among Chinese Elymus sibiricus accessions. Molecules. 2015;20:5987-6001 pubmed publisher
    ..Start Codon Targeted (SCoT) markers were used for studying the genetic diversity and relationships among 53 E...
  30. Zeng B, Huang X, Huang L, Zhang J, Yan H, Luo D, et al. Optimization of SCoT-PCR reaction system in Dactylis glomerata by orthogonal design. Genet Mol Res. 2015;14:3052-61 pubmed publisher
    ..on the polymerase chain reaction (PCR) were investigated to optimize the start codon targeted polymor-phism (SCoT)-PCR system of Dactylis glomerata L., using an orthogo-nal design L16 (4(5)). A suitable SCoT-PCR system for D...
  31. Tajbakht P, Talebi M, Rahimmalek M. Genetic diversity among and within Ferula asafoetida H. Karst. populations using molecular and phytochemical markers. Phytochemistry. 2018;155:19-29 pubmed publisher
    ..In this study, the genetic diversity of F. asafetida populations was assessed using SCoT and SRAP molecular markers. Nine SCoT and nine SRAP primer combinations amplified 211 and 194 bands, showing 96...
  32. Shen J, Huang G, An C, Xin X, Huang C, Rosendahl S. Removal of Tetrabromobisphenol A by adsorption on pinecone-derived activated charcoals: Synchrotron FTIR, kinetics and surface functionality analyses. Bioresour Technol. 2018;247:812-820 pubmed publisher
    ..In comparison, adsorption on activated charcoal from Scot pinecone was favored by the surface with high aromaticity and high surface area...
  33. Feußner H, Ostler D, Kohn N, Vogel T, Wilhelm D, Koller S, et al. [Comprehensive system integration and networking in operating rooms]. Chirurg. 2016;87:1002-1007 pubmed integration and networking in the operating room: the Japanese smart cyber operating theater (SCOT), the American medical device plug-and-play interoperability program (MDPnP) and the German secure and dynamic ..
  34. Mao R, Xia P, He Z, Liu Y, Liu F, Zhao H, et al. Identification of seeds based on molecular markers and secondary metabolites in Senna obtusifolia and Senna occidentalis. Bot Stud. 2017;58:43 pubmed publisher
    ..The results showed that selected 3 ISSR and 7 SCoT primers could distinguish S. obtusifolia seeds from S...
  35. Fordyce C, Newby D, Douglas P. Diagnostic Strategies for the Evaluation of Chest Pain: Clinical Implications From SCOT-HEART and PROMISE. J Am Coll Cardiol. 2016;67:843-52 pubmed publisher
    b>SCOT-HEART (Scottish COmputed Tomography of the HEART) and PROMISE (PROspective Multicenter Imaging Study for Evaluation of chest pain) represent the 2 largest and most comprehensive cardiovascular imaging outcome trials in patients with ..
  36. Billinger M, Brunner C, Müller Putz G. Online visualization of brain connectivity. J Neurosci Methods. 2015;256:106-16 pubmed publisher
    ..source extraction and regularized connectivity estimation, are available in our open source Python-based toolbox SCoT. We demonstrate for the first time that online connectivity visualization is feasible...
  37. Brisson H, Arbelot C, Monsel A, Parisot C, Girard M, Savier E, et al. Impact of graft preservation solutions for liver transplantation on early cytokine release and postoperative organ dysfunctions. A pilot study. Clin Res Hepatol Gastroenterol. 2017;41:564-574 pubmed publisher
    ..observational and prospective study was to compare the impact of Solution de conservation des organes et tissus (SCOT) 15 and University of Wisconsin (UW) preservation solutions on early cytokine release, postreperfusion syndrome and ..
  38. Charng J, Jacobson S, Heon E, Roman A, McGuigan D, Sheplock R, et al. Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells. Invest Ophthalmol Vis Sci. 2017;58:3215-3224 pubmed publisher
    ..Standard stimuli (2.5 log scot-cd.m-2; ?13 log; achromatic full-field) with 0.1- or 5-second duration were used in all patients...
  39. Rahmani M, Shabanian N, Khadivi Khub A, Woeste K, Badakhshan H, Alikhani L. Population structure and genotypic variation of Crataegus pontica inferred by molecular markers. Gene. 2015;572:123-129 pubmed publisher
    ..inter-retrotransposon amplified polymorphism (IRAP); inter-simple sequence repeats (ISSR) and start codon targeted (SCoT) polymorphism...
  40. Sulaiman R, Al Nemer M, Khan R, Almasned M, Handoum B, Al Hassnan Z. Successful Management of Pregnancies in Patients with Inherited Disorders of Ketone Body Metabolism. JIMD Rep. 2018;38:41-44 pubmed publisher
    Patients with succinyl-CoA:3-oxoacid CoA transferase (SCOT) deficiency and 3-hydroxy-3-methylglutaryl (HMG)-CoA lyase deficiency are at increased risk of developing metabolic acidosis and hypoglycemia during pregnancy, delivery, and ..
  41. Doris M, Newby D. Coronary CT Angiography as a Diagnostic and Prognostic Tool: Perspectives from the SCOT-HEART Trial. Curr Cardiol Rep. 2016;18:18 pubmed publisher
    ..The Scottish COmputed Tomography of the HEART (SCOT-HEART) trial sought to address these questions and determined whether CCTA, when used in addition to standard care, ..
  42. Quick T. A capital Scot: microscopes and museums in Robert E. Grant's zoology (1815-1840). Br J Hist Sci. 2016;49:173-204 pubmed publisher
    ..In so doing, it identifies the reliance of London-based natural philosophers on museology as constituting a limiting effect on the kinds of claim that Grant sought to make regarding the nature of life. ..
  43. Zhang J, Jia P, Liu Q, Cong M, Gao Y, Shi H, et al. Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo. J Lipid Res. 2018;59:625-634 pubmed publisher
    ..Downregulation of both BDH1 and OXCT1 rendered HeLa cells sensitive to the KD in vitro and in vivo. Tumors with low ketolytic enzyme expression may be unable to metabolize ketone bodies, thus predicting a better response to KD therapy. ..
  44. Zhang S, Xie C. The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism. Life Sci. 2017;183:110-115 pubmed publisher
    ..We also review recent efforts in exploring the mechanism responsible for the tumor promoting effect of OXCT1 and suggest a novel therapeutic target for cancer therapy. ..
  45. Williams M, Hunter A, Shah A, Assi V, Lewis S, Smith J, et al. Use of Coronary Computed Tomographic Angiography to Guide Management of Patients With Coronary Disease. J Am Coll Cardiol. 2016;67:1759-1768 pubmed publisher
    ..Scottish COmputed Tomography of the HEART Trial [SCOT-HEART]; NCT01149590).
  46. Adamson P, Hunter A, Madsen D, Shah A, McAllister D, Pawade T, et al. High-Sensitivity Cardiac Troponin I and the Diagnosis of Coronary Artery Disease in Patients With Suspected Angina Pectoris. Circ Cardiovasc Qual Outcomes. 2018;11:e004227 pubmed publisher
    ..In a prespecified substudy of the SCOT-HEART trial (Scottish Computed Tomography of the Heart), plasma cardiac troponin was measured using a high-..
  47. Zhang Y, Yan H, Jiang X, Wang X, Huang L, Xu B, et al. Genetic variation, population structure and linkage disequilibrium in Switchgrass with ISSR, SCoT and EST-SSR markers. Hereditas. 2016;153:4 pubmed publisher
    ..28 %) were polymorphic. Using a parameter marker index (MI), the efficiency of the three types of markers (ISSR, SCoT, and EST-SSR) in the study were compared and we found that SCoT had a higher marker efficiency than the other two ..
  48. Williams M, Hunter A, Shah A, Dreisbach J, Weir McCall J, Macmillan M, et al. Impact of noncardiac findings in patients undergoing CT coronary angiography: a substudy of the Scottish computed tomography of the heart (SCOT-HEART) trial. Eur Radiol. 2018;28:2639-2646 pubmed publisher
    ..This substudy of the SCOT-HEART randomized controlled trial assessed noncardiac findings identified on CCTA...
  49. Dragojević T, Varma H, Hollmann J, Valdés C, Culver J, Justicia C, et al. High-density speckle contrast optical tomography (SCOT) for three dimensional tomographic imaging of the small animal brain. Neuroimage. 2017;153:283-292 pubmed publisher
    High-density speckle contrast optical tomography (SCOT) utilizing tens of thousands of source-detector pairs, was developed for in vivo imaging of blood flow in small animals...
  50. Ngo T, Bartie K, Thompson K, Verner Jeffreys D, Hoare R, Adams A. Genetic and serological diversity of Flavobacterium psychrophilum isolates from salmonids in United Kingdom. Vet Microbiol. 2017;201:216-224 pubmed publisher
    ..The occurrence over time (up to 11 years) of F. psychrophilum pulsotypes in three representative sites (Scot I, Scot III and Scot V) within Scotland was examined, potentially providing important epidemiological data for farm ..
  51. Huang D, Li T, Wang L, Zhang L, Yan R, Li K, et al. Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress. Cell Res. 2016;26:1112-1130 pubmed publisher
    ..Taken together, we uncover here a novel metabolic adaptation by which nutrition-deprived HCC cells employ ketone bodies for energy supply and cancer progression. ..
  52. Perkins M, Wolf A, Chavira B, Shonebarger D, Meckel J, Leung L, et al. Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ?4 Carriers. J Alzheimers Dis. 2016;53:95-106 pubmed publisher
    ..glucose (GLUT1 & GLUT3) and monocarboxylate (MCT2) transporters, the glucose metabolism enzyme hexokinase, the SCOT & AACS enzymes involved in ketone metabolism, and complexes I, II, and IV of the mitochondrial electron ..
  53. Bittencourt M, Hulten E, Murthy V, Cheezum M, Rochitte C, Di Carli M, et al. Clinical Outcomes After Evaluation of Stable Chest Pain by Coronary Computed Tomographic Angiography Versus Usual Care: A Meta-Analysis. Circ Cardiovasc Imaging. 2016;9:e004419 pubmed publisher
    ..and revascularization was noted, which was attributable to the Scottish Computed Tomography of the HEART (SCOT-HEART) study. We found no difference in the rate of admission for cardiac chest pain (rate ratio, 1...
  54. Chen D, Li L, Zhang X, Wang Y. Genetic structure and genetic diversity of single-variety Lonicera macranthoides populations in China, as indicated by SCoT markers. Genet Mol Res. 2015;14:8058-67 pubmed publisher
    ..Results suggest that cultivar breeders should strengthen the exchange of germplasm and increase the mutual penetration of useful genes, which would broaden the hereditary basis of L. macranthoides. ..
  55. Chai X, Dong R, Liu W, Wang Y, Liu Z. Optimizing Sample Size to Assess the Genetic Diversity in Common Vetch (Vicia sativa L.) Populations Using Start Codon Targeted (SCoT) Markers. Molecules. 2017;22: pubmed publisher
    ..number of individuals that may represent the genetic diversity of a single population, using Start Codon Targeted (SCoT) markers...
  56. Rajesh M, Sabana A, Rachana K, Rahman S, Jerard B, Karun A. Genetic relationship and diversity among coconut (Cocos nucifera L.) accessions revealed through SCoT analysis. 3 Biotech. 2015;5:999-1006 pubmed publisher
    ..In the present study, we have used a simple and novel marker system, start codon targeted polymorphism (SCoT), for its evaluation as a potential marker system in coconut...
  57. Liang Q, Wang B, Pang L, Wang Y, Zheng M, Wang Q, et al. Application of citrate as a tricarboxylic acid (TCA) cycle intermediate, prevents diabetic-induced heart damages in mice. Iran J Basic Med Sci. 2016;19:43-8 pubmed
    ..marker proteins, tyrosine nitration, activity of ATP synthase and succinyl-CoA3-ketoacid coenzyme A transferase-1 (SCOT), and EC were measured...
  58. Keever Taylor C, Heimfeld S, Steinmiller K, Nash R, Sullivan K, Czarniecki C, et al. Manufacture of Autologous CD34+ Selected Grafts in the NIAID-Sponsored HALT-MS and SCOT Multicenter Clinical Trials for Autoimmune Diseases. Biol Blood Marrow Transplant. 2017;23:1463-1472 pubmed publisher
    ..Diseases-sponsored Investigational New Drug protocols for multiple sclerosis (HALT-MS) and systemic sclerosis (SCOT), a Drug Master File approach to control manufacture was implemented, including a common Master Production Batch ..
  59. McAnany J, Park J, Collison F, Fishman G, Stone E. Abnormal 8-Hz flicker electroretinograms in carriers of X-linked retinoschisis. Doc Ophthalmol. 2016;133:61-70 pubmed publisher
    ..of dark adaptation, 8- and 15-Hz ERGR, ERGC, and ERGR+C responses were obtained at a mean luminance level of 24 scot. cd/m(2). Standard ISCEV ERGs were also obtained from each subject...
  60. Bedi K, Snyder N, Brandimarto J, Aziz M, Mesaros C, WORTH A, et al. Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure. Circulation. 2016;133:706-16 pubmed publisher
  61. Balasubramaniam S, Lewis B, Greed L, Meili D, Flier A, Yamamoto R, et al. Heterozygous Monocarboxylate Transporter 1 (MCT1, SLC16A1) Deficiency as a Cause of Recurrent Ketoacidosis. JIMD Rep. 2016;29:33-38 pubmed
    ..A thiolase ("beta-ketothiolase") and succinyl-coenzyme A: 3-oxoacyl coenzyme A transferase (SCOT) deficiencies. A single heterozygous c.982C>T transition in the SLC16A1 gene resulting in a stop mutation (p...
  62. Hao J, Jiao K, Yu C, Guo H, Zhu Y, Yang X, et al. Development of SCoT-Based SCAR Marker for Rapid Authentication of Taxus Media. Biochem Genet. 2018;56:255-266 pubmed publisher Through a screening of 36 start codon targeted (SCoT) polymorphism primers, among 15 individuals of 4 Taxus species (T. media, T. chinensis, T. cuspidate and T...
  63. Grosser T, Ricciotti E, Fitzgerald G. The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs. Trends Pharmacol Sci. 2017;38:733-748 pubmed publisher
    ..Celecoxib Outcome Trial (SCOT) and Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen (PRECISION), ..
  64. Lu J, Lu D, Chen Y, Dong Y, Zhang J, Li T, et al. Proteomic analysis of hepatocellular carcinoma HepG2 cells treated with platycodin D. Chin J Nat Med. 2015;13:673-9 pubmed publisher
    ..The changes in HSP27 and PHB were further confirmed by Western blotting. In conclusion, our results shed new lights on the mechanisms of action for the anti-cancer activity of PD. ..
  65. Yan H, Zhang Y, Zeng B, Yin G, Zhang X, Ji Y, et al. Genetic Diversity and Association of EST-SSR and SCoT Markers with Rust Traits in Orchardgrass (Dactylis glomerata L.). Molecules. 2016;21:66 pubmed publisher
    ..genetic diversity was assessed and the marker-trait associations for rust were examined using 18 EST-SSR and 21 SCoT markers in 75 orchardgrass accessions...
  66. Fukao T, Ishii T, Amano N, Kursula P, Takayanagi M, Murase K, et al. A neonatal-onset succinyl-CoA:3-ketoacid CoA transferase (SCOT)-deficient patient with T435N and c.658-666dupAACGTGATT p.N220_I222dup mutations in the OXCT1 gene. J Inherit Metab Dis. 2010;33 Suppl 3:S307-13 pubmed publisher
    Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency causes episodic ketoacidotic crises and no apparent symptoms between them. Here, we report a Japanese case of neonatal-onset SCOT deficiency...
  67. Wagner T, McLaughlin S, Garg K, Cheung C, Larsen B, Styrchak S, et al. HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science. 2014;345:570-3 pubmed publisher
    ..Over time on ART, a greater proportion of persisting proviruses were in proliferating cells. HIV integration into specific genes may promote proliferation of HIV-infected cells, slowing viral decay during ART...
  68. Gajera H, Hirpara D, Katakpara Z, Patel S, Golakiya B. Molecular evolution and phylogenetic analysis of biocontrol genes acquired from SCoT polymorphism of mycoparasitic Trichoderma koningii inhibiting phytopathogen Rhizoctonia solani Kuhn. Infect Genet Evol. 2016;45:383-392 pubmed publisher
    ..The antagonists Trichoderma strains were performed for start codon targeted (SCoT) polymorphism to acquire biocontrol genes from potent antagonist...
  69. Zołnierowicz S, Scisłowski P, Swierczynski J, Zelewski L. Acetoacetate utilization by human placental mitochondria. Placenta. 1984;5:271-6 pubmed
    ..It is proposed that acetoacetate utilization by placental mitochondria proceeds via the conversion to acetoacetyl-CoA catalysed by 3-oxoacid-CoA transferase, and then to acetyl-CoA, catalysed by acetoacetyl-CoA thiolase. ..
  70. Roner S, Vlachopoulos L, Nagy L, Schweizer A, Fürnstahl P. Accuracy and Early Clinical Outcome of 3-Dimensional Planned and Guided Single-Cut Osteotomies of Malunited Forearm Bones. J Hand Surg Am. 2017;42:1031.e1-1031.e8 pubmed publisher
    ..A SCOT combined with patient-specific guides is an accurate and reliable technique to restore normal anatomy in ..
  71. Maurer G, Brucker D, Bähr O, Harter P, Hattingen E, Walenta S, et al. Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. BMC Cancer. 2011;11:315 pubmed publisher
    ..Further investigations are necessary to identify co-treatment modalities, e.g. glycolysis inhibitors or antiangiogenic agents that efficiently target non-oxidative pathways. ..
  72. Sorkheh K, Amirbakhtiar N, Ercisli S. Retraction Note to: Potential Start Codon Targeted (SCoT) and Interretrotransposon Amplified Polymorphism (IRAP) Markers for Evaluation of Genetic Diversity and Conservation of Wild Pistacia Species Population. Biochem Genet. 2017;55:421-422 pubmed publisher
    ..Upon investigation carried out according to the Committee on Publication Ethics guidelines, it has been found that the authors have duplicated or rephrased parts from other articles of which the main sources...
  73. Miao C, Li Y, Yang J, Mao R. Landscape genomics reveal that ecological character determines adaptation: a case study in smoke tree (Cotinus coggygria Scop.). BMC Evol Biol. 2017;17:202 pubmed publisher
    ..Using fifteen natural populations and nine start codon targeted (SCoT) markers, a total of 1131 unambiguous loci were yielded...
  74. Perez Cerda C, Merinero B, Sanz P, Jimenez A, Hernandez C, Garcia M, et al. A new case of succinyl-CoA: acetoacetate transferase deficiency. J Inherit Metab Dis. 1992;15:371-3 pubmed
  75. Atia M, Sakr M, Adawy S. Assessing Date Palm Genetic Diversity Using Different Molecular Markers. Methods Mol Biol. 2017;1638:125-142 pubmed publisher
    ..multidisciplinary molecular marker approaches: amplified fragment length polymorphism (AFLP), start codon targeted (SCoT) polymorphism, conserved DNA-derived polymorphism (CDDP), intron-targeted amplified polymorphism (ITAP), simple ..
  76. Okamoto J, Masamune K, Iseki H, Muragaki Y. Development concepts of a Smart Cyber Operating Theater (SCOT) using ORiN technology. Biomed Tech (Berl). 2017;: pubmed publisher
    ..In this project, we aim to develop a networked operating room called "Smart Cyber Operating Theater (SCOT)". Medical devices are connected using Open Resource interface for the Network (ORiN) technology...
  77. Fukao T, Sakurai S, Rolland M, Zabot M, Schulze A, Yamada K, et al. A 6-bp deletion at the splice donor site of the first intron resulted in aberrant splicing using a cryptic splice site within exon 1 in a patient with succinyl-CoA: 3-Ketoacid CoA transferase (SCOT) deficiency. Mol Genet Metab. 2006;89:280-2 pubmed
    Succinyl-CoA: 3-ketoacid-CoA transferase (SCOT; locus symbol OXCT, EC deficiency is a rare genetic disorder affecting ketone body utilization in extra-hepatic tissues...
  78. Orii K, Fukao T, Song X, Mitchell G, Kondo N. Liver-specific silencing of the human gene encoding succinyl-CoA: 3-ketoacid CoA transferase. Tohoku J Exp Med. 2008;215:227-36 pubmed
    The human succinyl-CoA: 3-ketoacid CoA transferase (SCOT) gene encodes the ketolytic enzyme that functions in the mitochondrial matrix...
  79. Cullis P, Davis C. George Macaulay: A short biography and his place in the history of congenital diaphragmatic hernia. J Pediatr Surg. 2018;53:217-219 pubmed publisher
    George Macaulay (1716-1766) was a Scot admired for his work as an obstetric physician, philanthropist, author, and feminist, but whom history has largely forgotten...
  80. Atia M, Sakr M, Mokhtar M, Adawy S. Development of Sex-Specific PCR-Based Markers in Date Palm. Methods Mol Biol. 2017;1638:227-244 pubmed publisher palm genotypes; these are amplified fragment length polymorphism (AFLP), start codon targeted polymorphism (SCoT), conserved DNA-derived polymorphism (CDDP), intron-targeted amplified polymorphism (ITAP), and random amplified ..
  81. Shafqat N, Kavanagh K, Sass J, Christensen E, Fukao T, Lee W, et al. A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency. J Inherit Metab Dis. 2013;36:983-7 pubmed publisher
    Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency is a rare inherited metabolic disorder of ketone metabolism, characterized by ketoacidotic episodes and often permanent ketosis...
  82. Nagao M, Toh R, Irino Y, Mori T, Nakajima H, Hara T, et al. ?-Hydroxybutyrate elevation as a compensatory response against oxidative stress in cardiomyocytes. Biochem Biophys Res Commun. 2016;475:322-8 pubmed publisher
    ..The gene and protein expression levels of CoA transferase (SCOT), a key enzyme involved in ketone body oxidation, was decreased in failing hearts...
  83. Adamson P, Fordyce C, McAllister D, Udelson J, Douglas P, Newby D. Identification of patients with stable chest pain deriving minimal value from coronary computed tomography angiography: An external validation of the PROMISE minimal-risk tool. Int J Cardiol. 2018;252:31-34 pubmed publisher
    ..We assessed the external validity of this tool within the context of the Scottish Computed Tomography of the HEART (SCOT-HEART) multicenter randomised controlled trial of patients with suspected stable angina due to coronary disease...
  84. Ozsvári B, Sotgia F, Simmons K, Trowbridge R, Foster R, Lisanti M. Mitoketoscins: Novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs). Oncotarget. 2017;8:78340-78350 pubmed publisher
    ..We propose that this new class of drugs should be termed "mitoketoscins", to reflect that they were designed to target ketone re-utilization and mitochondrial function...
  85. Igwe D, Afiukwa C, Ubi B, Ogbu K, Ojuederie O, Ude G. Assessment of genetic diversity in Vigna unguiculata L. (Walp) accessions using inter-simple sequence repeat (ISSR) and start codon targeted (SCoT) polymorphic markers. BMC Genet. 2017;18:98 pubmed publisher
    ..programs, hence, the comparative assessment of Inter-simple sequence repeat (ISSR) and Start codon targeted (SCoT) markers in genetic diversity of V. unguiculata accessions from different regions in Nigeria...
  86. Sasai H, Aoyama Y, Otsuka H, Abdelkreem E, Naiki Y, Kubota M, et al. Heterozygous carriers of succinyl-CoA:3-oxoacid CoA transferase deficiency can develop severe ketoacidosis. J Inherit Metab Dis. 2017;40:845-852 pubmed publisher
    Succinyl-CoA:3-oxoacid CoA transferase (SCOT, gene symbol OXCT1) deficiency is an autosomal recessive disorder in ketone body utilization that results in severe recurrent ketoacidotic episodes in infancy, including neonatal periods...
  87. MacDonald M, Longacre M, Langberg E, Tibell A, Kendrick M, Fukao T, et al. Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes. Diabetologia. 2009;52:1087-91 pubmed publisher
    ..enzymes, glycerol phosphate dehydrogenase, pyruvate carboxylase (PC) and succinyl-CoA:3-ketoacid-CoA transferase (SCOT) were decreased by 73%, 65% and 92%, respectively, in the diabetic compared with the non-diabetic islets...