SCN2A

Summary

Gene Symbol: SCN2A
Description: sodium voltage-gated channel alpha subunit 2
Alias: BFIC3, BFIS3, BFNIS, EIEE11, HBA, HBSCI, HBSCII, NAC2, Na(v)1.2, Nav1.2, SCN2A1, SCN2A2, sodium channel protein type 2 subunit alpha, HBSC II, sodium channel protein brain II subunit alpha, sodium channel protein type II subunit alpha, sodium channel protein, brain type 2 alpha subunit, sodium channel, voltage-gated, type II, alpha 1 polypeptide, sodium channel, voltage-gated, type II, alpha 2 polypeptide, sodium channel, voltage-gated, type II, alpha subunit, voltage-gated sodium channel subtype II, voltage-gated sodium channel subunit alpha Nav1.2, voltage-gated sodium channel type II alpha subunit
Species: human
Products:     SCN2A

Top Publications

  1. Lakhan R, Kumari R, Misra U, Kalita J, Pradhan S, Mittal B. Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population. Br J Clin Pharmacol. 2009;68:214-20 pubmed publisher
    ..Thr 1067 Ala or c.3184 A-->G (rs2298771) and SCN2A p.Arg19Lys or c.56 G-->A (rs17183814) in north Indian epilepsy patients...
  2. Pandya K, Clark G, Lau Cam C. Investigation of the Role of a Supplementation with Taurine on the Effects of Hypoglycemic-Hypotensive Therapy Against Diabetes-Induced Nephrotoxicity in Rats. Adv Exp Med Biol. 2017;975 Pt 1:371-400 pubmed publisher
    ..ones exhibited frank hyperglycemia (+313%), hypoinsulinemia (-76%) and elevation of the glycated hemoglobin value (HbA1c, +207%)...
  3. Yang Z, Tao G, Guo M, Sun B, Gong L, Ding Y, et al. [Efficacy and safety of simulated artificial pancreas in modulating stress hyperglycemia in critically ill patients: a prospective randomized controlled study]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018;30:165-169 pubmed publisher
    ..1 mmol/L or higher, glycated hemoglobin (HbA1C) below 0...
  4. Ranasinghe P, Galappaththy P, Constantine G, Jayawardena R, Weeratunga H, Premakumara S, et al. Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial. Trials. 2017;18:446 pubmed publisher
    ..The following primary outcome measures will be evaluated: glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG) and serum insulin...
  5. Derosa G, Gaudio G, Pasini G, D Angelo A, Maffioli P. A randomized, double-blind clinical trial of canrenone vs hydrochlorothiazide in addition to angiotensin II receptor blockers in hypertensive type 2 diabetic patients. Drug Des Devel Ther. 2018;12:2611-2616 pubmed publisher
    ..HCTZ also worsened glycated hemoglobin (HbA1c), while canrenone did not change it...
  6. Baba S, Takashima T, Hirota M, Kawashima M, Horikawa E. Relationship between pulmonary function and elevated glycated hemoglobin levels in health checkups: A cross-sectional observational study in Japanese participants. J Epidemiol. 2017;27:511-515 pubmed publisher
    ..between pulmonary function tests using spirometry (PFT) and fasting plasma glucose (FPG) or glycated hemoglobin (HbA1c) levels in Japanese participants...
  7. Mazidi M, Katsiki N, Kengne A, Mikhailidis D, Banach M. Adiposity mediates the association between whole grain consumption, glucose homeostasis and insulin resistance: findings from the US NHANES. Lipids Health Dis. 2018;17:219 pubmed publisher
    ..insulin, homeostatic model assessment of IR (HOMA-IR) and β cell function (HOMA-β), hemoglobin A1c (HbA1c), and 2 h glucose after an oral glucose tolerance test decreased with increasing quarters of WG (all ..
  8. Du S, Wu X, Han T, Duan W, Liu L, Qi J, et al. Dietary manganese and type 2 diabetes mellitus: two prospective cohort studies in China. Diabetologia. 2018;61:1985-1995 pubmed publisher
    ..were performed to investigate the association between dietary Mn and type 2 diabetes (diagnosed by OGTT) or HbAlc and to analyse the joint association between dietary Mn and TAC...
  9. Zhou M, Zhu L, Cui X, Feng L, Zhao X, He S, et al. Reduced peripheral blood mtDNA content is associated with impaired glucose-stimulated islet ? cell function in a Chinese population with different degrees of glucose tolerance. Diabetes Metab Res Rev. 2016;32:768-774 pubmed publisher
    ..Levels of HbA1c , plasma glucose, insulin and C-peptide were also determined...

More Information

Publications159 found, 100 shown here

  1. Græsli A, Evans A, Fahlman Ã, Bertelsen M, Blanc S, Arnemo J. Seasonal variation in haematological and biochemical variables in free-ranging subadult brown bears (Ursus arctos) in Sweden. BMC Vet Res. 2015;11:301 pubmed publisher
    ..transpeptidase (GGT), glutamate dehydrogenase (GD) and amylase, and increased values of β-hydroxybutyrate (β-HBA) and blood lipids; triglycerides, cholesterol and free fatty acids, were present during hibernation compared to ..
  2. Jepson C, Hsu J, Fischer M, Kusek J, Lash J, Ricardo A, et al. Incident Type 2 Diabetes Among Individuals With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2019;73:72-81 pubmed publisher
    ..Measures of kidney function and damage, fasting blood glucose, hemoglobin A1c (HbA1c), HOMA-IR (homeostatic model assessment of insulin resistance), demographics, family history of ..
  3. Mazidi M, Cicero A, Kengne A, Banach M. Association Between Plasma Trans-Fatty Acid Concentrations and Measures of Glucose Homeostasis and Cardiovascular Risk Factors in Adults in NHANES 1999-2000. Angiology. 2017;:3319717745987 pubmed publisher
    ..analyses, mean waist circumference, fat-free mass, fat mass, C-peptide, insulin, hemoglobin A1c (HbA1c), homeostatic model assessment of insulin resistance (HOMA-IR), serum triglycerides (TGs), and total ..
  4. Koren D, Levitt Katz L, Brar P, Gallagher P, Berkowitz R, Brooks L. Sleep architecture and glucose and insulin homeostasis in obese adolescents. Diabetes Care. 2011;34:2442-7 pubmed publisher
    ..Hemoglobin A(1c) (HbA(1c)) and serial insulin and glucose levels were obtained, indices of insulin sensitivity and secretion were ..
  5. Andersen B, Straarup E, Heppner K, Takahashi D, Raffaele V, Dissen G, et al. FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys. Int J Obes (Lond). 2018;42:1151-1160 pubmed publisher
    ..Overall glucose tolerance was improved with a small but significant decrease in HbA1C...
  6. Li X, Meng X, Gao X, Pang X, Wang Y, Wu X, et al. Elevated Serum Xanthine Oxidase Activity Is Associated With the Development of Type 2 Diabetes: A Prospective Cohort Study. Diabetes Care. 2018;41:884-890 pubmed publisher
    ..indexes including fasting blood glucose (FBG), 2-h blood glucose (PBG), glycosylated hemoglobin A1c (HbA1c), and fasting insulin were tested for analysis. During an average follow-up period of 4...
  7. Hassanin K, Mahmoud M, Hassan H, Abdel Razik A, Aziz L, Rateb M. Balanites aegyptiaca ameliorates insulin secretion and decreases pancreatic apoptosis in diabetic rats: Role of SAPK/JNK pathway. Biomed Pharmacother. 2018;102:1084-1091 pubmed publisher
    ..Moreover, BA treatment produced a reduction in plasma glucose, HbA1c, lactic acid, lipid profile, malondialdehyde levels and produced an increase in insulin, reduced ..
  8. Dargad R, Prajapati M, Dargad R, Parekh J. Sacubitril/valsartan: A novel angiotensin receptor-neprilysin inhibitor. Indian Heart J. 2018;70 Suppl 1:S102-S110 pubmed publisher
    ..Besides, pleiotropic benefits like HbA1c reduction, better eGFR progression and a greater decrease in blood pressure and serum creatinine ..
  9. Zhao Z, Liu C, Zhang Q, Zhang B, Guo J, Yuan A, et al. [Acupuncture Treatment Reduces Body Weight Possibly by Down-regulating Insulin and Leptin Resistance, and Up-regulating Soluble Leptin Receptor Level in Prediabetic Patients]. Zhen Ci Yan Jiu. 2018;43:506-11 pubmed publisher
    ..ratio (WHR), 2 h-postprandial blood glucose (2 h-PBG), fasting blood glucose (FBG), glycosyla-ted hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), fasting insulin (FINS), serum LP and sOB-R levels were ..
  10. Gajos G, Siniarski A, Natorska J, Zabczyk M, Siudut J, Malinowski K, et al. Polyhedrocytes in blood clots of type 2 diabetic patients with high cardiovascular risk: association with glycemia, oxidative stress and platelet activation. Cardiovasc Diabetol. 2018;17:146 pubmed publisher
    ..In 97 patients with long-standing T2D [median HbA1c, 6.4% (interquartile range 5.9-7...
  11. Li X, Liu H, Feng H, Xian Z, Chen Y, Chen J, et al. Acupuncture paired with herbal medicine for prediabetes: study protocol for a randomized controlled trial. Trials. 2017;18:297 pubmed publisher
    ..2-h plasma glucose (2-hPG) level after a 75-g oral glucose tolerance test (OGTT), and glycosylated hemoglobin (HbA1c) level...
  12. Brown H, Anastasi M, Frank L, Kind K, Richani D, Robker R, et al. Hemoglobin: a gas transport molecule that is hormonally regulated in the ovarian follicle in mice and humans. Biol Reprod. 2015;92:26 pubmed publisher
    ..We previously found Hba-a1 and Hbb mRNA and protein at high levels within mouse periovulatory cumulus cells, but not in cumulus following ..
  13. Neumiller J, Campbell R. Saxagliptin: a dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus. Am J Health Syst Pharm. 2010;67:1515-25 pubmed publisher
    ..rosiglitazone have demonstrated clinical benefits in various glycemic endpoints, including glycosylated hemoglobin (HbA(1c)), fasting plasma glucose (FPG), and postprandial glucose (PPG) levels over 24 to 102 weeks of therapy...
  14. Wang S, Andrews C, Herman W, Gardner T, Stein J. Incidence and Risk Factors for Developing Diabetic Retinopathy among Youths with Type 1 or Type 2 Diabetes throughout the United States. Ophthalmology. 2017;124:424-430 pubmed publisher
    ..diabetes mellitus diagnosis, sex, race/ethnicity, net worth, and glycated hemoglobin A1c fraction (HbA1c). Hazard ratios (HRs) with 95% confidence intervals (CIs) for developing DR...
  15. Saraf S, Sysol J, Susma A, Setty S, Zhang X, Gudehithlu K, et al. Progressive glomerular and tubular damage in sickle cell trait and sickle cell anemia mouse models. Transl Res. 2018;197:1-11 pubmed publisher
    ..differential expression of several genes involved in prostaglandin metabolism (AKR1C18), heme and iron metabolism (HbA-A2, HMOX1, SCL25A37), electrolyte balance (SLC4A1, AQP6), immunity (RSAD2, C3, UBE2O), fatty acid metabolism (FASN),..
  16. Ndila C, Uyoga S, Macharia A, Nyutu G, Peshu N, Ojal J, et al. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study. Lancet Haematol. 2018;5:e333-e345 pubmed publisher
    ..genes or locations, of which most were related to red blood cells: ABO, ATP2B4, ARL14, CD40LG, FREM3, INPP4B, G6PD, HBA (both HBA1 and HBA2), HBB, IL10, LPHN2 (also known as ADGRL2), LOC727982, RPS6KL1, CAND1, and GNAS...
  17. Sachdeva A, Dharavath R, Chopra K. Time-response studies on development of cognitive deficits in an experimental model of insulin resistance. Clin Nutr. 2018;: pubmed publisher
    ..Body weight, food and water intake were weekly monitored. Fasting blood glucose, glycosylated hemoglobin (HbA1C), lipid profiling, plasma insulin, HOMA-IR index, and systolic blood pressure were estimated to ..
  18. Li D, Wei H, Xue H, Zhang J, Chen M, Gong Y, et al. Higher serum 25(OH)D level is associated with decreased risk of impairment of glucose homeostasis: data from Southwest China. BMC Endocr Disord. 2018;18:25 pubmed publisher
    ..Indices describing glucose homeostasis included fasting plasma glucose (FPG), fasting insulin, glycated hemoglobin (HbA1c), the homeostatic model assessment 2-insulin resistance (HOMA2-IR) and odds of pre-diabetes...
  19. Fujiwara T, Okamoto K, Niikuni R, Takahashi K, Okitsu Y, Fukuhara N, et al. Effect of 5-aminolevulinic acid on erythropoiesis: a preclinical in vitro characterization for the treatment of congenital sideroblastic anemia. Biochem Biophys Res Commun. 2014;454:102-8 pubmed publisher
    ..analysis confirmed significant upregulation of heme-regulated genes, such as the globin genes [hemoglobin alpha (HBA) and hemoglobin gamma (HBG)] and the heme oxygenase 1 (HMOX1) gene, in K562 cells...
  20. Chen W, Lai Y, Lin S, Lu K, Lin Y, Panyod S, et al. Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling. J Ethnopharmacol. 2016;182:190-9 pubmed publisher
    ..Gastrodin (GAS) and 4-hydroxybenzyl alcohol (HBA) in WGE, were analyzed with high-performance liquid chromatography (HPLC)-ultraviolet detection...
  21. Feig D, Donovan L, Corcoy R, Murphy K, Amiel S, Hunt K, et al. Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial. Lancet. 2017;390:2347-2359 pubmed publisher
    ..Randomisation was stratified by insulin delivery (pump or injections) and baseline glycated haemoglobin (HbA1c)...
  22. Howse P, Chibrikova L, Twells L, Barrett B, Gamble J. Safety and Efficacy of Incretin-Based Therapies in Patients With Type 2 Diabetes Mellitus and CKD: A Systematic Review and Meta-analysis. Am J Kidney Dis. 2016;68:733-742 pubmed publisher
    ..Changes in glycated hemoglobin (HbA1c), hypoglycemia, mortality, change in fasting plasma glucose, cardiovascular events, and end-stage ..
  23. Ruggenenti P, Abbate M, Ruggiero B, Rota S, Trillini M, Aparicio C, et al. Renal and Systemic Effects of Calorie Restriction in Patients With Type 2 Diabetes With Abdominal Obesity: A Randomized Controlled Trial. Diabetes. 2017;66:75-86 pubmed publisher
    ..than nonhyperfiltering patients and was associated with BMI, waist circumference, blood pressure, heart rate, HbA1c, blood glucose, LDL-to-HDL cholesterol ratio, C-reactive protein, angiotensin II, and albuminuria ..
  24. Gossage Worrall R, Holt R, Barnard K, E Carey M, J Davies M, Dickens C, et al. STEPWISE - STructured lifestyle Education for People WIth SchizophrEnia: a study protocol for a randomised controlled trial. Trials. 2016;17:475 pubmed
    ..activity (wrist accelerometer); self-reported diet; blood pressure; fasting plasma glucose, lipid profile and HbA1c (baseline and 1 year only); health-related quality of life (EQ-5D-5L and RAND SF-36); (adapted) brief ..
  25. Dhananjayan I, Kathiroli S, Subramani S, Veerasamy V. Ameliorating effect of betanin, a natural chromoalkaloid by modulating hepatic carbohydrate metabolic enzyme activities and glycogen content in streptozotocin - nicotinamide induced experimental rats. Biomed Pharmacother. 2017;88:1069-1079 pubmed publisher
    ..w. of betanin was able to positively regulate plasma glucose, insulin, glycosylated hemoglobin (HbA1c) and hemoglobin (Hb) levels by significantly increasing the activity of glycolytic enzyme (glucokinase ..
  26. König M, Gollasch M, Rosada A, Demuth I, Spira D, Steinhagen Thiessen E. Antihypertensive Treatment Patterns and Blood Pressure Control in Older Adults: Results from the Berlin Aging Study II. Drugs Aging. 2018;35:993-1003 pubmed publisher
    ..Number and choice of BP medications were not predictive of BP control; neither were age, glycated hemoglobin (HbA1c), kidney function, or number of healthcare visits...
  27. Pastuszak A, Kohn T, Estis J, Lipshultz L. Low Plasma Testosterone Is Associated With Elevated Cardiovascular Disease Biomarkers. J Sex Med. 2017;14:1095-1103 pubmed publisher
    ..lipoprotein (HDL) cholesterol, high-sensitivity C-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), and leptin. Association of CV risk markers with levels of T in men...
  28. Barr E, Barzi F, Hughes J, Jerums G, Hoy W, O Dea K, et al. High Baseline Levels of Tumor Necrosis Factor Receptor 1 Are Associated With Progression of Kidney Disease in Indigenous Australians With Diabetes: The eGFR Follow-up Study. Diabetes Care. 2018;41:739-747 pubmed publisher
    ..Baseline measures included sTNFR1, serum creatinine, urine albumin-to-creatinine ratio (uACR), HbA1c, C-reactive protein (CRP), waist-to-hip ratio, systolic blood pressure, and medical history...
  29. Tonucci L, Olbrich Dos Santos K, Licursi de Oliveira L, Rocha Ribeiro S, Duarte Martino H. Clinical application of probiotics in type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled study. Clin Nutr. 2017;36:85-92 pubmed publisher
    ..01). There was a significant difference between groups concerning mean changes of HbA1c (+0.31 for control group vs -0.65 for probiotic group; p=0.02), total cholesterol (+0...
  30. Ludvik B, Frias J, Tinahones F, Wainstein J, Jiang H, Robertson K, et al. Dulaglutide as add-on therapy to SGLT2 inhibitors in patients with inadequately controlled type 2 diabetes (AWARD-10): a 24-week, randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2018;6:370-381 pubmed publisher
    ..Eligible adult patients (≥18 years) with inadequately controlled type 2 diabetes (HbA1c concentration ≥7·0% [53 mmol/mol] and ≤9·5% [80 mmol/mol]), a BMI of 45 kg/m2 or less,..
  31. Hallberg S, McKenzie A, Williams P, Bhanpuri N, Peters A, Campbell W, et al. Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study. Diabetes Ther. 2018;9:583-612 pubmed publisher
    ..Primary outcomes were glycosylated hemoglobin (HbA1c), weight, and medication use...
  32. Horvath G, Demos M, Shyr C, Matthews A, Zhang L, Race S, et al. Secondary neurotransmitter deficiencies in epilepsy caused by voltage-gated sodium channelopathies: A potential treatment target?. Mol Genet Metab. 2016;117:42-8 pubmed publisher
    ..Whole exome sequencing identified a de novo SCN2A splice-site mutation (c.2379+1G>A, p.Glu717Gly...
  33. de Lima L, Brandão P, Donegatti T, Ramos R, Goncalves L, Cardoso A, et al. 4-hydrazinobenzoic acid as a derivatizing agent for aldehyde analysis by HPLC-UV and CE-DAD. Talanta. 2018;187:113-119 pubmed publisher
    ..Herein, 4-hydrazinobenzoic acid (HBA) was, for the first time, used as the derivatizing agent in analytical methodologies using liquid chromatography ..
  34. Turner T, Hormozdiari F, Duyzend M, McClymont S, Hook P, Iossifov I, et al. Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative Noncoding Regulatory DNA. Am J Hum Genet. 2016;98:58-74 pubmed publisher
    ..dosage sensitivity has already been established by recurrent disruptive de novo protein-coding mutations (ARID1B, SCN2A, NR3C2, PRKCA, and DSCAM)...
  35. Mitsunaga F, Umezawa M, Takeda K, Nakamura S. Maternal administration of nanomaterials elicits hemoglobin upregulation in the neonatal brain of non-human primates. J Toxicol Sci. 2016;41:265-71 pubmed publisher
    ..RT-PCR, western blot, and immunohistochemical analyses were used to measure the expression of the hemoglobin genes, HBA, HBB, and HBG...
  36. Yanni A, Stamataki N, Konstantopoulos P, Stoupaki M, Abeliatis A, Nikolakea I, et al. Controlling type-2 diabetes by inclusion of Cr-enriched yeast bread in the daily dietary pattern: a randomized clinical trial. Eur J Nutr. 2018;57:259-267 pubmed publisher
    ..Plasma glucose, insulin, glycosylated hemoglobin (HbA1c) and insulin resistance were determined, and oral glucose tolerance test (OGTT) was performed at the ..
  37. Vasandani C, Clark G, Adams Huet B, Quittner C, Garg A. Efficacy and Safety of Metreleptin Therapy in Patients With Type 1 Diabetes: A Pilot Study. Diabetes Care. 2017;40:694-697 pubmed publisher
    ..Metreleptin therapy did not lower HbA1c significantly compared with the baseline value (mean difference -0.19% [-2.0 mmol/mol] and -0.04% [-0...
  38. Han Y, Kim K, Park Y, Song S, Yang Y, Lee K, et al. Boronate-functionalized hydrogel as a novel biosensing interface for the glycated hemoglobin A1c (HbA1c) based on the competitive binding with signaling glycoprotein. Mater Sci Eng C Mater Biol Appl. 2017;77:1160-1169 pubmed publisher
    ..mellitus, the development of new glycemic monitoring techniques based on the biosensing of glycated hemoglobin A1c (HbA1c), a promising long-term glycemic biomarker, has become a major challenge...
  39. Schneider A, Selvin E, Sharrett A, Griswold M, Coresh J, Jack C, et al. Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS). Diabetes Care. 2017;40:1514-1521 pubmed publisher
    To examine the associations of prediabetes, diabetes, and diabetes severity (as assessed by HbA1c and diabetes duration) with brain volumes and vascular pathology on brain MRI and to assess whether the associations of diabetes ..
  40. Roy A, Ranjan A. HosA, a MarR Family Transcriptional Regulator, Represses Nonoxidative Hydroxyarylic Acid Decarboxylase Operon and Is Modulated by 4-Hydroxybenzoic Acid. Biochemistry. 2016;55:1120-34 pubmed publisher
    ..A systematic chemical search for the physiological ligand revealed that 4-hydroxybenzoic acid (4-HBA) interacts with HosA and derepresses HosA mediated repression of the nonoxidative HAD operon...
  41. Khunti K, Mohan V, Jain S, Boesgaard T, Begtrup K, Sethi B. Efficacy and Safety of IDegLira in Participants with Type 2 Diabetes in India Uncontrolled on Oral Antidiabetic Drugs and Basal Insulin: Data from the DUAL Clinical Trial Program. Diabetes Ther. 2017;8:673-682 pubmed publisher
    ..In the Indian subpopulations, the reductions in glycated hemoglobin (HbA1c) with IDegLira were substantial [DUAL I: 1.96% (-21 mmol/mol); DUAL IV: -1...
  42. Su Z, Han S, Fu Z, Qian G, Liu F. Heat-Stable Antifungal Factor (HSAF) Biosynthesis in Lysobacter enzymogenes Is Controlled by the Interplay of Two Transcription Factors and a Diffusible Molecule. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..4-Hydroxybenzoic acid (4-HBA) is a newly identified diffusible factor that regulates HSAF synthesis via L...
  43. Pereira S, Vieira J, Barroca F, Roll P, Carvalhas R, Cau P, et al. Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A. Neurology. 2004;63:191-2 pubmed
  44. Sabath D, BENDER M, Sankaran V, Vamos E, Kentsis A, Yi H, et al. Characterization of Deletions of the HBA and HBB Loci by Array Comparative Genomic Hybridization. J Mol Diagn. 2016;18:92-9 pubmed publisher
    ..Thalassemia is usually caused by deletion of one or more of the duplicated HBA genes on chromosome 16...
  45. Skrtic S, Cabrera C, Olsson M, Schnecke V, Lind M. Contemporary risk estimates of three HbA1c variables in relation to heart failure following diagnosis of type 2 diabetes. Heart. 2017;103:353-358 pubmed publisher
    ..The association between each of three different haemoglobin A1C (HbA1c) metrics and HF was estimated using adjusted proportional hazard models...
  46. Gilsanz P, Karter A, Beeri M, Quesenberry C, Whitmer R. The Bidirectional Association Between Depression and Severe Hypoglycemic and Hyperglycemic Events in Type 1 Diabetes. Diabetes Care. 2018;41:446-452 pubmed publisher
    ..and severe dysglycemia in both directions, adjusting for demographics, micro- and macrovascular complications, and HbA1c...
  47. Saeed H, Saleem Z, Naeem R, Shahzadi I, Islam M. Impact of health literacy on diabetes outcomes: a cross-sectional study from Lahore, Pakistan. Public Health. 2018;156:8-14 pubmed publisher
    ..003), education levels (P = 0.0005), socio-economic status levels (P = 0.0005) and glycated haemoglobin (HbA1C) levels (P = 0.0005) differed significantly with health literacy level...
  48. Xu L, Borges M, Hemani G, Lawlor D. The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study. Diabetologia. 2017;60:2210-2220 pubmed publisher
    ..2 diabetes (34,840 case vs 114,981 control participants), fasting glucose (n = 46,186), insulin (n = 38,238), HbA1c (n = 46,368) and LDL-cholesterol, HDL-cholesterol and triacylglycerols (n = 188,577); (2) the ..
  49. Li L, Tan K, Aris I, Chong Y, Saw S, Gluckman P, et al. Gestational retinal microvasculature and the risk of 5 year postpartum abnormal glucose metabolism. Diabetologia. 2017;60:2368-2376 pubmed publisher
    ..follow-up period (n = 103) or (2) had prediabetes (impaired fasting glucose, impaired glucose tolerance or HbA1c 5.7-6...
  50. Taggart L, Truesdale M, Carey M, Martin Stacey L, Scott J, Bunting B, et al. Pilot feasibility study examining a structured self-management diabetes education programme, DESMOND-ID, targeting HbA1c in adults with intellectual disabilities. Diabet Med. 2018;35:137-146 pubmed publisher
    ..on the outcomes of a pilot feasibility study of a structured self-management diabetes education programme targeting HbA1c ...
  51. Cradock K, Olaighin G, Finucane F, Gainforth H, Quinlan L, Ginis K. Behaviour change techniques targeting both diet and physical activity in type 2 diabetes: A systematic review and meta-analysis. Int J Behav Nutr Phys Act. 2017;14:18 pubmed publisher
    ..dietary and physical activity interventions for patients with type 2 diabetes that are associated with changes in HbA1c and body weight...
  52. Qu H, Qiu Y, Wang Y, Liao Y, Zheng Y, Zheng H. Plasma fetuin-B concentrations are associated with insulin resistance and first-phase glucose-stimulated insulin secretion in individuals with different degrees of glucose tolerance. Diabetes Metab. 2018;44:488-492 pubmed publisher
    ..001) and positively correlated with FPG, 2hPG, HOMA-IR, HbA1c, hsCRP, FINS and TG (P<0...
  53. Celik A, Pouwels S, Karaca F, Çağıltay E, Ugale S, Etikan Ä, et al. Time to Glycemic Control - an Observational Study of 3 Different Operations. Obes Surg. 2017;27:694-702 pubmed publisher
    ..Included patients had a body mass index (BMI) ≥30 kg/m2; T2DM for ≥3 years, HbA1C > 7 % for ≥3 months, and no significant weight change (>3 %) within the ..
  54. Pilemann Lyberg S, Lindhardt M, Persson F, Andersen S, Rossing P. Serum uric acid and progression of diabetic nephropathy in type 1 diabetes. J Diabetes Complications. 2018;32:470-473 pubmed publisher
    ..UA was tested in a linear regression model adjusted for known progression factors (gender, HbA1c, systolic blood pressure, cholesterol, baseline GFR and baseline urinary albumin excretion rate (UAER))..
  55. Guan G, Zhao M, Xu X, Boczek T, Mao X, Li Z, et al. Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma. Neurosci Lett. 2018;674:148-155 pubmed publisher
    ..This study represents the first evidence of the abnormal changes in VGSCs subtypes and CaM/CaMKII pathway in human brain low-grade astrocytoma, providing new potential targets for molecular therapies of this disease. ..
  56. Ogawa S, Takafuji K, Tsubuku S, Horie Y, Ikegawa S, Higashi T. Isotope-coded derivatization based LC/ESI-MS/MS methods using a pair of novel reagents for quantification of hydroxycinnamic acids and hydroxybenzoic acids in fermented brown rice product. J Pharm Biomed Anal. 2017;142:162-170 pubmed publisher
    ..to LC/ESI-MS/MS; by this method, we found that the fermentation process significantly increased the free HCA and HBA contents...
  57. Hirsch A, Durden T, Nordberg C, Berger A, Schwartz B. Associations of Four Community Factors With Longitudinal Change in Hemoglobin A1c Levels in Patients With Type 2 Diabetes. Diabetes Care. 2018;41:461-468 pubmed publisher
    To evaluate associations of community factors with glycated hemoglobin (HbA1c). We identified patients with type 2 diabetes who had an HbA1c ≥7...
  58. Dawoud D, O Mahony R, Wonderling D, Cobb J, Higgins B, Amiel S. Basal Insulin Regimens for Adults with Type 1 Diabetes Mellitus: A Systematic Review and Network Meta-Analysis. Value Health. 2018;21:176-184 pubmed publisher
    ..Two outcomes (change in hemoglobin A1c [HbA1c] and rate of severe/major hypoglycemia [SH]) were analyzed...
  59. Birch S, Lenox M, Kornegay J, Shen L, Ai H, Ren X, et al. Computed tomography assessment of peripubertal craniofacial morphology in a sheep model of binge alcohol drinking in the first trimester. Alcohol. 2015;49:675-89 pubmed publisher
    ..Pregnant sheep were randomly assigned to four groups: heavy binge alcohol, 2.5 g/kg/day (HBA); binge alcohol, 1.75 g/kg/day (BA); saline control (SC); and normal control (NC)...
  60. Bergenstal R, Strock E, Mazze R, Powers M, Monk A, Richter S, et al. Diurnal glucose exposure profiles of patients treated with lixisenatide before breakfast or the main meal of the day: An analysis using continuous glucose monitoring. Diabetes Metab Res Rev. 2017;33: pubmed publisher
    ..8) to 3880.9 (1165.0) mg/dL*24 h in the main meal group (P = .0224). For patients included in the substudy, HbA1c decreased by approximately 0.6% in both groups...
  61. Cherney D, Zinman B, Inzucchi S, Koitka Weber A, Mattheus M, von Eynatten M, et al. Effects of empagliflozin on the urinary albumin-to-creatinine ratio in patients with type 2 diabetes and established cardiovascular disease: an exploratory analysis from the EMPA-REG OUTCOME randomised, placebo-controlled trial. Lancet Diabetes Endocrinol. 2017;5:610-621 pubmed publisher
    ..with a computer-generated random-sequence and interactive voice-response and web-response system, stratified by HbA1c, BMI, region, and estimated glomerular filtration rate...
  62. Simonson D, Halperin F, Foster K, Vernon A, Goldfine A. Clinical and Patient-Centered Outcomes in Obese Patients With Type 2 Diabetes 3 Years After Randomization to Roux-en-Y Gastric Bypass Surgery Versus Intensive Lifestyle Management: The SLIMM-T2D Study. Diabetes Care. 2018;41:670-679 pubmed publisher
    ..3 ± 3.4 kg/m2, age 52 ± 6 years, and HbA1c 8.5 ± 1.3% [69 ± 14 mmol/mol]) to laparoscopic RYGB (n = 19) or IMWM (n = 19)...
  63. Kumar S, Jang H, Demirag N, Skjøth T, Endahl L, Bode B. Efficacy and safety of once-daily insulin degludec/insulin aspart compared with once-daily insulin glargine in participants with Type 2 diabetes: a randomized, treat-to-target study. Diabet Med. 2017;34:180-188 pubmed publisher
    ..9-4.9 mmol/l (70-89 mg/dl)]. IDegAsp once daily was non-inferior to IGlar once daily in reducing HbA1c after 26 weeks [mean estimated treatment difference IDegAsp once daily - IGlar once daily: -0...
  64. Hiscock J, Bustone G, Wilson B, Belsey K, Blackholly L. In situ modification of nanostructure configuration through the manipulation of hydrogen bonded amphiphile self-association. Soft Matter. 2016;12:4221-8 pubmed publisher
    ..report the synthesis of a novel amphiphilic salt containing a number of hydrogen bond donating (HBD) and accepting (HBA) functionalities...
  65. Laber K, Newcomer C, Decelle T, Everitt J, Guillen J, Brønstad A. Recommendations for Addressing Harm-Benefit Analysis and Implementation in Ethical Evaluation - Report from the AALAS-FELASA Working Group on Harm-Benefit Analysis - Part 2. Lab Anim. 2016;50:21-42 pubmed publisher
    ..the authority responsible for the review of animal studies has concluded a well-thought-out harm-benefit analysis (HBA) and deemed the project to be appropriate...
  66. Lee K, Hwang B, Kim T, Kim C, Kim J, Choo E, et al. Computed Tomography Angiography Images of Coronary Artery Stenosis Provide a Better Prediction of Risk Than Traditional Risk Factors in Asymptomatic Individuals With Type 2 Diabetes: A Long-term Study of Clinical Outcomes. Diabetes Care. 2017;40:1241-1248 pubmed publisher
    ..risk factors, including age, male, hypertension, hyperlipidemia, smoking, estimated glomerular filtration rate, and HbA1c...
  67. Osborn C, van Ginkel J, Marrero D, Rodbard D, Huddleston B, Dachis J. One Drop | Mobile on iPhone and Apple Watch: An Evaluation of HbA1c Improvement Associated With Tracking Self-Care. JMIR Mhealth Uhealth. 2017;5:e179 pubmed publisher
    The One Drop | Mobile app supports manual and passive (via HealthKit and One Drop's glucose meter) tracking of self-care and glycated hemoglobin A1c (HbA1c).
  68. Wolff M, Johannesen K, Hedrich U, Masnada S, Rubboli G, Gardella E, et al. Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders. Brain. 2017;140:1316-1336 pubmed publisher
    Mutations in SCN2A, a gene encoding the voltage-gated sodium channel Nav1.2, have been associated with a spectrum of epilepsies and neurodevelopmental disorders...
  69. Kelly C, Hookham M, Yu J, Jenkins A, Nankervis A, Hanssen K, et al. Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes. Diabetes Care. 2018;41:120-127 pubmed publisher
    ..02). Accounting for BMI, HbA1c, and total daily insulin dose, a doubling of uNGALcc at V1 conferred a sevenfold increase in risk for ..
  70. Schwandt A, Hermann J, Rosenbauer J, Boettcher C, Dunstheimer D, Grulich Henn J, et al. Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling Approach. Diabetes Care. 2017;40:309-316 pubmed publisher
    Worsening of glycemic control in type 1 diabetes during puberty is a common observation. However, HbA1c remains stable or even improves for some youths...
  71. Khanuja P, Narula S, Rajput R, Sharma R, Tewari S. Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population. Front Med. 2017;11:110-119 pubmed publisher
    ..Blood analyses were carried out for glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), 2 h post parandial glucose (PPG)...
  72. Parrow N, Tu H, Nichols J, Violet P, Pittman C, Fitzhugh C, et al. Measurements of red cell deformability and hydration reflect HbF and HbA2 in blood from patients with sickle cell anemia. Blood Cells Mol Dis. 2017;65:41-50 pubmed publisher
    ..be influenced by the concentration of alternative hemoglobins such as fetal hemoglobin (HbF) and the adult variant, HbA2...
  73. Hoyer A, Rathmann W, Kuss O. Utility of HbA1c and fasting plasma glucose for screening of Type 2 diabetes: a meta-analysis of full ROC curves. Diabet Med. 2017;: pubmed publisher
    ..for population-based screening of diabetes (diagnosed by the oral glucose tolerance test) using tests like HbA1c or fasting plasma glucose. Meta-analyses provide meaningful input in such situations...
  74. Chan J, Ho B, Alvi H, Saltzman M, Marra G. The relationship between the incidence of adhesive capsulitis and hemoglobin A1c. J Shoulder Elbow Surg. 2017;26:1834-1837 pubmed publisher
    Previous studies have shown no correlation between adhesive capsulitis and hemoglobin A1c (HbA1c). However, HbA1c is only a measure of short-term blood sugar control...
  75. Erickson M, Little J, Gay J, McCully K, Jenkins N. Postmeal exercise blunts postprandial glucose excursions in people on metformin monotherapy. J Appl Physiol (1985). 2017;123:444-450 pubmed publisher
    ..on postprandial glucose excursions in 10 people treated with metformin monotherapy (57 ± 10 yr, HbA1C = 6.3 ± 0.6%)...
  76. Pratley R, Aroda V, Lingvay I, Lüdemann J, Andreassen C, Navarria A, et al. Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial. Lancet Diabetes Endocrinol. 2018;6:275-286 pubmed publisher
    ..Eligible patients were aged 18 years or older and had type 2 diabetes with HbA1c 7·0-10·5% (53·0-91·0 mmol/mol) on metformin monotherapy...
  77. Hawkins N, Martin M, Frankel W, Kearney J, Escayg A. Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus. Neurobiol Dis. 2011;41:655-60 pubmed publisher
    Mutations in the neuronal voltage-gated sodium channel genes SCN1A and SCN2A are associated with inherited epilepsies, including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (severe myoclonic epilepsy of ..
  78. Banerjee S, Chakraborti A. Methylglyoxal modification enhances the stability of hemoglobin and lowers its iron-mediated oxidation reactions: An in vitro study. Int J Biol Macromol. 2017;95:1159-1168 pubmed publisher
    ..study, we have investigated the in vitro effect of methylglyoxal (200, 300?m) on the heme protein hemoglobin (HbA0) (100?m) after incubation for one week at 25°C...
  79. Olson H, Kelly M, LaCoursiere C, Pinsky R, Tambunan D, Shain C, et al. Genetics and genotype-phenotype correlations in early onset epileptic encephalopathy with burst suppression. Ann Neurol. 2017;81:419-429 pubmed publisher
    ..burst suppression, we identified variants predicted to be pathogenic in KCNQ2 (n = 10), STXBP1 (n = 2), SCN2A (n = 2), PNPO (n = 1), PIGA (n = 1), and SEPSECS (n = 1)...
  80. Karamat M, Dar S, Bellary S, Tahrani A. Clinical and Cost Implications of Insulin Degludec in Patients with Type 1 Diabetes and Problematic Hypoglycemia: A Quality Improvement Project. Diabetes Ther. 2018;9:839-849 pubmed publisher
    ..At 6 months, there was a significant reduction in median (interquartile range) HbA1c, from 8.6 (8.0-9.3)% [70 (64-78) mmol/mol] to 8.4 (7.9-8.9)% [68 (63-74) mmol/mol]; p < 0.05...
  81. Shi X, Yasumoto S, Kurahashi H, Nakagawa E, Fukasawa T, Uchiya S, et al. Clinical spectrum of SCN2A mutations. Brain Dev. 2012;34:541-5 pubmed publisher
    Mutations in SCN2A, the gene encoding ?2 subunit of the neuronal sodium channel, are associated with a variety of epilepsies: benign familial neonatal-infantile seizures (BFNIS); genetic epilepsy with febrile seizures plus (GEFS+); ..
  82. Byrkjeland R, Njerve I, Anderssen S, Arnesen H, Seljeflot I, Solheim S. Effects of exercise training on HbA1c and VO2peak in patients with type 2 diabetes and coronary artery disease: A randomised clinical trial. Diab Vasc Dis Res. 2015;12:325-33 pubmed publisher
    ..b>HbA(1c) was measured at the beginning and end of the study...
  83. Schmitt A, Reimer A, Kulzer B, Icks A, Paust R, Roelver K, et al. Measurement of psychological adjustment to diabetes with the diabetes acceptance scale. J Diabetes Complications. 2018;32:384-392 pubmed publisher
    ..distress (PAID-5), depressive symptoms (PHQ-9), quality of life (EQ-5D), self-management (DSMQ), glycaemic control (HbA1c) and complications. Internal reliability was high (Cronbach's α = 0.96)...
  84. Cavero Redondo I, Peleteiro B, Álvarez Bueno C, Artero E, Garrido Miguel M, Martínez Vizcaíno V. The Effect of Physical Activity Interventions on Glycosylated Haemoglobin (HbA1c) in Non-diabetic Populations: A Systematic Review and Meta-analysis. Sports Med. 2018;48:1151-1164 pubmed publisher
    ..review was to estimate the effect of physical activity on glycaemic control measured by glycosylated haemoglobin (HbA1c) levels in non-diabetic populations, and to determine which type of physical activity has a greater ..
  85. Schade S, Brown G. Identifying the promoter region of the human brain sodium channel subtype II gene (SCN2A). Brain Res Mol Brain Res. 2000;81:187-90 pubmed
    Sodium channel genes are highly regulated. To begin analyzing the human brain sodium channel subtype II gene, SCN2A, at the transcriptional level, we mapped multiple transcriptional start sites within a 397 bp stretch of the 5'-UTR and -..
  86. Zaccagnini L, Brogi S, Brindisi M, Gemma S, Chemi G, Legname G, et al. Identification of novel fluorescent probes preventing PrPSc replication in prion diseases. Eur J Med Chem. 2017;127:859-873 pubmed publisher
    ..toxicity and able to inhibit PrPSc accumulation in vitro in prion-infected neuroblastoma cell lines (ScN2a). In this assay, the pyrroloquinoxaline hydrazone 96 showed the higest potency with an IC50 value of 1...
  87. Plant L, Marks J, GOLDSTEIN S. SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. elife. 2016;5: pubmed publisher
    ..Given the recognized role of INa in hypoxic brain damage, the SUMO pathway and NaV1.2 are identified as potential targets for neuroprotective interventions. ..
  88. Munasinghe L, Mastroeni M, Mastroeni S, Loehr S, Ekwaru J, Veugelers P. The Association of Serum 25-Hydroxyvitamin D Concentrations and Elevated Glycated Hemoglobin Values: A Longitudinal Study of Non-Diabetic Participants of a Preventive Health Program. Nutrients. 2017;9: pubmed publisher
    ..D [25(OH)D] concentrations, are paralleled by a reduction in the risk for reaching adverse glycated hemoglobin (HbA1c) levels in a community sample of non-diabetic volunteers participating in a preventive health program ..
  89. She J, Deng Y, Wu Y, Xia Y, Li H, Liang X, et al. Hemoglobin A1c is associated with severity of coronary artery stenosis but not with long term clinical outcomes in diabetic and nondiabetic patients with acute myocardial infarction undergoing primary angioplasty. Cardiovasc Diabetol. 2017;16:97 pubmed publisher
    ..In this study, we investigate the relationship between admission HbA1c and severity of coronary artery stenosis and subsequent prognosis in AMI patients with or without ..
  90. Olsson M, Schnecke V, Cabrera C, Skrtic S, Lind M. Contemporary Risk Estimates of Three HbA1c Variables for Myocardial Infarction in 101,799 Patients Following Diagnosis of Type 2 Diabetes. Diabetes Care. 2015;38:1481-6 pubmed publisher
    ..In the overall cohort (n = 101,799), the risk increase for MI per 1% (10 mmol/mol) increase in HbA(1c) was higher for updated latest and updated mean HbA(1c) of 1.11 (95% CI 1.09-1.13) and 1.15 (1.13-1...
  91. Schwarz N, Hahn A, Bast T, Müller S, Löffler H, Maljevic S, et al. Mutations in the sodium channel gene SCN2A cause neonatal epilepsy with late-onset episodic ataxia. J Neurol. 2016;263:334-43 pubmed publisher
    Mutations in SCN2A cause epilepsy syndromes of variable severity including neonatal-infantile seizures. In one case, we previously described additional childhood-onset episodic ataxia...
  92. Gray B, Stephens J, Turner D, Thomas M, Williams S, Morgan K, et al. A non-exercise method to determine cardiorespiratory fitness identifies females predicted to be at 'high risk' of type 2 diabetes. Diab Vasc Dis Res. 2017;14:47-54 pubmed
    ..5 metabolic equivalents (Quintile 5). Body mass index, waist circumference, and HbA1c all decreased between increasing non-exercise testing method for estimating fitness quintiles (p?<?..