Gene Symbol: SCN10A
Description: sodium voltage-gated channel alpha subunit 10
Alias: FEPS2, Nav1.8, PN3, SNS, hPN3, sodium channel protein type 10 subunit alpha, peripheral nerve sodium channel 3, sodium channel protein type X subunit alpha, sodium channel, voltage-gated, type X, alpha polypeptide, sodium channel, voltage-gated, type X, alpha subunit, voltage-gated sodium channel subunit alpha Nav1.8
Species: human
Products:     SCN10A

Top Publications

  1. Rabert D, Koch B, Ilnicka M, Obernolte R, Naylor S, Herman R, et al. A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. Pain. 1998;78:107-14 pubmed
    ..In this study, a human sodium channel (hPN3, SCN10A) has been cloned from the lumbar 4/5 dorsal root ganglia (DRG)...
  2. Catterall W, Goldin A, Waxman S. International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev. 2005;57:397-409 pubmed
    ..This article presents the molecular relationships and physiological roles of these sodium channel proteins and provides comprehensive information on their molecular, genetic, physiological, and pharmacological properties. ..
  3. Pfeufer A, van Noord C, Marciante K, Arking D, Larson M, Smith A, et al. Genome-wide association study of PR interval. Nat Genet. 2010;42:153-9 pubmed publisher
    ..At the 3p22.2 locus, we observed two independent associations in voltage-gated sodium channel genes, SCN10A and SCN5A...
  4. Chambers J, Zhao J, Terracciano C, Bezzina C, Zhang W, Kaba R, et al. Genetic variation in SCN10A influences cardiac conduction. Nat Genet. 2010;42:149-52 pubmed publisher
    ..We identified association of a nonsynonymous SNP, rs6795970, in SCN10A (P = 2.8 x 10(-15)) with PR interval, a marker of cardiac atrioventricular conduction...
  5. Plummer N, Meisler M. Evolution and diversity of mammalian sodium channel genes. Genomics. 1999;57:323-31 pubmed
  6. Holm H, Gudbjartsson D, Arnar D, Thorleifsson G, Thorgeirsson G, Stefansdottir H, et al. Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet. 2010;42:117-22 pubmed publisher
    ..6 x 10(-7)). We identified one locus for heart rate (MYH6), four for PR interval (TBX5, SCN10A, CAV1 and ARHGAP24) and four for QRS duration (TBX5, SCN10A, 6p21 and 10q21)...
  7. Bellinger D, Lorton D. Sympathetic Nerve Hyperactivity in the Spleen: Causal for Nonpathogenic-Driven Chronic Immune-Mediated Inflammatory Diseases (IMIDs)?. Int J Mol Sci. 2018;19: pubmed publisher
    ..of common inflammatory process that are used by the immune system across all IMIDs, novel strategies to restore SNS homeostasis are expected to provide safe, cost-effective approaches to treat IMIDs, lower comorbidities, and ..
  8. Ransome Y, Slopen N, Karlsson O, Williams D. The association between alcohol abuse and neuroendocrine system dysregulation: Race differences in a National sample. Brain Behav Immun. 2017;66:313-321 pubmed publisher
    ..of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively...
  9. Rojas D, Tegeder I, Kuner R, Agarwal N. Hypoxia-inducible factor 1α protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species. J Mol Med (Berl). 2018;96:1395-1405 pubmed publisher
    ..Genetically modified mutant mice, which conditionally lack HIF1α in peripheral sensory neurons (SNS-HIF1α-/-), were analyzed longitudinally up to 6 months in the streptozotocin (STZ) model of type1 ..

More Information

Publications143 found, 100 shown here

  1. Chatterjee S, Yadav S. The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code. Life (Basel). 2019;9: pubmed publisher
    ..refinement of the translation machines: the GNC code that was developed by the pre-tRNA/pre-aaRS /pre-mRNA machine, SNS code by the tRNA/aaRS/mRNA machine, and finally the universal genetic code by the tRNA/aaRS/mRNA/ribosome machine...
  2. Cossa A, Lima D, do Vale T, de Alencar Rocha A, da Graça Naffah Mazzacoratti M, da Silva Fernandes M, et al. Maternal seizures can affect the brain developing of offspring. Metab Brain Dis. 2016;31:891-900 pubmed publisher
    ..was used to analyze protein levels of Bax, Bcl-2 and Poly(ADP-ribose) polymerase-1 (PARP-1) in the hippocampus (PN3-PN21)...
  3. Cheng F, Ma C, Wang X, Zhai C, Wang G, Xu X, et al. Effect of traditional Chinese medicine formula Sinisan on chronic restraint stress-induced nonalcoholic fatty liver disease: a rat study. BMC Complement Altern Med. 2017;17:203 pubmed publisher
    ..A Chinese medicine Sinisan (SNS) may be a potential formula for treating this kind of disease...
  4. Seoane Collazo P, Fernø J, Gonzalez F, Diéguez C, Leis R, Nogueiras R, et al. Hypothalamic-autonomic control of energy homeostasis. Endocrine. 2015;50:276-91 pubmed publisher
    ..The ANS consists of two parts, the sympathetic and parasympathetic nervous systems (SNS and PSNS)...
  5. Majzúnová M, Pakanova Z, Kvasnička P, Balis P, Cacanyiova S, Dovinova I. Age-dependent redox status in the brain stem of NO-deficient hypertensive rats. J Biomed Sci. 2017;24:72 pubmed publisher
    The brain stem contains important nuclei that control cardiovascular function via the sympathetic nervous system (SNS), which is strongly influenced by nitric oxide...
  6. Muller M, Enderle J, Pourhassan M, Braun W, Eggeling B, Lagerpusch M, et al. Metabolic adaptation to caloric restriction and subsequent refeeding: the Minnesota Starvation Experiment revisited. Am J Clin Nutr. 2015;102:807-19 pubmed publisher
    ..7%), creatinine clearance (-12%), energy cost of walking (-22%), activity of the sympathetic nervous system (SNS) (-38%), and plasma leptin (-44%), insulin (-54%), adiponectin (-49%), 3,5,3'-tri-iodo-thyronine (T3) (-39%), and ..
  7. Le P, Bishop K, Maridas D, Motyl K, Brooks D, Nagano K, et al. Spontaneous mutation of Dock7 results in lower trabecular bone mass and impaired periosteal expansion in aged female Misty mice. Bone. 2017;105:103-114 pubmed publisher
    ..While the low bone mineral density phenotype is in part due to higher sympathetic nervous system (SNS) drive in young mice, it is unclear what effect aging would have in mice homozygous for the mutation in the Dock7 ..
  8. Straznicky N, Grima M, Sari C, Lambert E, Phillips S, Eikelis N, et al. Reduction in peripheral vascular resistance predicts improvement in insulin clearance following weight loss. Cardiovasc Diabetol. 2015;14:113 pubmed publisher
    ..This study was conducted to examine the inter-relationships between changes in sympathetic nervous system (SNS) activity, vascular function and insulin clearance during a weight loss program...
  9. Xiao F, Guo Y, Deng J, Yuan F, Xiao Y, Hui L, et al. Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals. Mol Metab. 2019;20:138-148 pubmed publisher
    ..Moreover, the activity of sympathetic nervous system (SNS) was increased in c-jun△li mice and the higher body temperature was inhibited by beta-adrenergic ..
  10. Lingeshwar P, Kaur G, Singh N, Singh S, Mishra A, Shukla S, et al. A study on the involvement of GABA-transaminase in MCT induced pulmonary hypertension. Pulm Pharmacol Ther. 2016;36:10-21 pubmed publisher
    Increased sympathetic nervous system (SNS) activity is associated with cardiovascular diseases but its role has not been completely explored in pulmonary hypertension (PH)...
  11. Gavini C, Jones W, Novak C. Ventromedial hypothalamic melanocortin receptor activation: regulation of activity energy expenditure and skeletal muscle thermogenesis. J Physiol. 2016;594:5285-301 pubmed publisher expenditure (EE) and physical activity, decreasing appetite and modulating sympathetic nervous system (SNS) outflow...
  12. Maestroni G. Adrenergic Modulation of Hematopoiesis. J Neuroimmune Pharmacol. 2019;: pubmed publisher
    ..In addition one has to consider that, physiologically, the sympathetic nervous system (SNS) activity follows a circadian rhythmicity as driven by the suprachiasmatic nucleus (SCN) of the hypothalamus but ..
  13. Holmes A, Wong S, Pulix M, Johnson K, Horton N, Thomas P, et al. Reductions in hypothalamic Gfap expression, glial cells and ?-tanycytes in lean and hypermetabolic Gnasxl-deficient mice. Mol Brain. 2016;9:39 pubmed publisher
    ..undernutrition, while surviving adults remain lean and hypermetabolic with increased sympathetic nervous system (SNS) activity. Effects of this knock-out on the hypothalamic neural network have not yet been investigated...
  14. Nestel P, Khan A, Straznicky N, Mellett N, Jayawardana K, Mundra P, et al. Markers of sympathetic nervous system activity associate with complex plasma lipids in metabolic syndrome subjects. Atherosclerosis. 2017;256:21-28 pubmed publisher
    ..of subjects with metabolic syndrome (MetS) showed close relationships between IR and sympathetic nervous system (SNS) activity including arterial norepinephrine (NE)...
  15. Roggero E, Perez A, Pollachini N, Villar S, Wildmann J, Besedovsky H, et al. The sympathetic nervous system affects the susceptibility and course of Trypanosoma cruzi infection. Brain Behav Immun. 2016;58:228-236 pubmed publisher
    ..hypothalamus-pituitary-adrenal (HPA) axis usually operates in a concerted way with the sympathetic nervous system (SNS), we have now studied whether noradrenergic nerves can affect the course of T...
  16. Feng Q, Lu C, Wang L, Song L, Li C, Uppada R. Effects of renal denervation on cardiac oxidative stress and local activity of the sympathetic nervous system and renin-angiotensin system in acute myocardial infracted dogs. BMC Cardiovasc Disord. 2017;17:65 pubmed publisher
    ..To measure the local activity of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS), the levels of tyrosine hydroxylase (TH), angiotensin II (AngII), angiotensin-..
  17. Di Battista A, Rhind S, Hutchison M, Hassan S, Shiu M, Inaba K, et al. Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury. J Neuroinflammation. 2016;13:40 pubmed publisher
    Traumatic brain injury (TBI) elicits intense sympathetic nervous system (SNS) activation with profuse catecholamine secretion. The resultant hyperadrenergic state is linked to immunomodulation both within the brain and systemically...
  18. Lorenz J, Schäfer N, Bauer R, Jenei Lanzl Z, Springorum R, Grässel S. Norepinephrine modulates osteoarthritic chondrocyte metabolism and inflammatory responses. Osteoarthritis Cartilage. 2016;24:325-34 pubmed publisher
    ..The sympathetic nervous system (SNS) may have a dual function in OA pathology with preserving a stable chondrocyte phenotype via β-AR signaling and ..
  19. Conceição E, Moura E, Soares P, Ai X, Figueiredo M, Oliveira E, et al. High calcium diet improves the liver oxidative stress and microsteatosis in adult obese rats that were overfed during lactation. Food Chem Toxicol. 2016;92:245-55 pubmed publisher
    ..Thus, we evaluated if dietary calcium can improve these changes. In PN3, litter size was adjusted to 3 pups (SL group) to induce overfeeding, while controls had 10 pups until weaning...
  20. Straznicky N, Grima M, Sari C, Eikelis N, Lambert G, Nestel P, et al. Pioglitazone treatment enhances the sympathetic nervous system response to oral carbohydrate load in obese individuals with metabolic syndrome. Metabolism. 2015;64:797-803 pubmed publisher
    Insulin resistance is associated with blunted sympathetic nervous system (SNS) response to carbohydrate ingestion which may contribute to postprandial hypotension and impaired body weight homeostasis...
  21. Garretson J, Szymanski L, Schwartz G, Xue B, Ryu V, Bartness T. Lipolysis sensation by white fat afferent nerves triggers brown fat thermogenesis. Mol Metab. 2016;5:626-634 pubmed publisher
    ..agonist CL316,243 dose-dependently increased: 1) phosphorylation of IWAT hormone sensitive lipase, an indicator of SNS-stimulated lipolysis, 2) expression of the neuronal activation marker c-Fos in dorsal root ganglion neurons ..
  22. Siddiqui A, Madhu S, Sharma S, Desai N. Endocrine stress responses and risk of type 2 diabetes mellitus. Stress. 2015;18:498-506 pubmed publisher
    ..of hypothalamic-pituitary-adrenal (HPA) axis and salivary α-amylase, a marker of sympathetic nervous system (SNS) were compared in 125 subjects of newly detected diabetes mellitus (NDDM) and normal glucose tolerance (NGT) ..
  23. Gil D, Wang J, Gu C, Donello J, Cabrera S, Al Chaer E. Role of sympathetic nervous system in rat model of chronic visceral pain. Neurogastroenterol Motil. 2016;28:423-31 pubmed publisher
    ..We investigated whether sympathetic nervous system (SNS) exacerbation of pain sensation when central pain inhibition is reduced is relevant to chronic pain disorders using ..
  24. Lee C, Park K, Baik S, Jeong S. Decreased excitability and voltage-gated sodium currents in aortic baroreceptor neurons contribute to the impairment of arterial baroreflex in cirrhotic rats. Am J Physiol Regul Integr Comp Physiol. 2016;310:R1088-101 pubmed publisher
    ..Taken together, these findings implicate a key cellular mechanism in the cirrhosis-impaired arterial baroreflex. ..
  25. Li Z, Jiang H, Chen D, Liu Q, Geng J, Guo J, et al. Renal sympathetic denervation improves cardiac dysfunction in rats with chronic pressure overload. Physiol Res. 2015;64:653-62 pubmed
    ..enlargement, and the left ventricular wall hypertrophy; inhibits the overdrive of the sympathetic nervous system (SNS), renin-angiotensin-aldosterone system (RAAS), and AVP system in TAC rats with chronic pressure overload...
  26. Hazell T, Islam H, Townsend L, Schmale M, Copeland J. Effects of exercise intensity on plasma concentrations of appetite-regulating hormones: Potential mechanisms. Appetite. 2016;98:80-8 pubmed publisher
    ..ghrelin, while other mechanisms involving cytokine release, changes in plasma glucose and insulin concentrations, SNS activity, and muscle metabolism likely mediate changes in the anorexigenic signals PYY and GLP-1...
  27. Huan H, Wen X, Chen X, Wu L, Wu L, Zhang L, et al. Sympathetic nervous system promotes hepatocarcinogenesis by modulating inflammation through activation of alpha1-adrenergic receptors of Kupffer cells. Brain Behav Immun. 2017;59:118-134 pubmed publisher
    The sympathetic nervous system (SNS) is known to play a significant role in tumor initiation and metastasis...
  28. Khademi S, Frye M, Jeckel K, Schroeder T, Monnet E, Irwin D, et al. Hypoxia mediated pulmonary edema: potential influence of oxidative stress, sympathetic activation and cerebral blood flow. BMC Physiol. 2015;15:4 pubmed publisher
    ..Plasma catecholamines were measured as markers of sympathetic nervous system (SNS) activity...
  29. Singh R, El Nashar S, Trabuco E, Klingele C, Gebhart J, Occhino J. Comparison of Short Term Outcomes of Sacral Nerve Stimulation and Intradetrusor Injection of OnabotulinumtoxinA (Botox) in Women With Refractory Overactive Bladder. Female Pelvic Med Reconstr Surg. 2015;21:369-73 pubmed publisher
    The aim of the study was to compare the short-term outcomes of sacral nerve stimulation (SNS) and intradetrusor injection of OnabotulinumtoxinA (Botox) for overactive bladder (OAB) symptoms refractory to behavioral modifications and ..
  30. Stoetzer C, Papenberg B, Doll T, Völker M, Heineke J, Stoetzer M, et al. Differential inhibition of cardiac and neuronal Na(+) channels by the selective serotonin-norepinephrine reuptake inhibitors duloxetine and venlafaxine. Eur J Pharmacol. 2016;783:1-10 pubmed publisher
    ..8 29±2). Duloxetine, but not venlafaxine inhibits cardiac Na(+)-channels with a potency similar to amitriptyline. These data indicate that an inhibition of Na(+)-channels does not predict a clinically relevant cardiotoxicity. ..
  31. Sarkanen T, Alakuijala A, Partinen M. Clinical course of H1N1-vaccine-related narcolepsy. Sleep Med. 2016;19:17-22 pubmed publisher
    ..pNT1 subjects completed Epworth Sleepiness Scale (ESS), Ullanlinna Narcolepsy Scale (UNS), Swiss Narcolepsy Scale (SNS), Rimon's Brief Depression scale (RDS), and WHO-5 Well-being index questionnaires near the disease onset and in a ..
  32. Eberhardt M, Leffler A. [Pain and analgesia : Mutations of voltage-gated sodium channels]. Schmerz. 2017;31:14-22 pubmed publisher
    ..This review offers an overview of published work on painful Nav mutations with clinical relevance, and proposes possible consequences for the therapy of different pain symptoms resulting from these findings. ..
  33. Liu J, Hao L, Zhang X, Shan Z, Li S, Fan S, et al. Painful Schmorl's nodes treated by discography and discoblock. Eur Spine J. 2018;27:13-18 pubmed publisher
    ..of discography and discoblock in the treatment of low back pain (LBP) associated with painful Schmorl's nodes (SNs). Between January 2010 and February 2015, 46 patients were studied who had LBP suspected to be secondary to SNs...
  34. Spiller L, Grierson P, Davies P, Hemmi J, Collin S, Kelley J. Functional diversity of the lateral line system among populations of a native Australian freshwater fish. J Exp Biol. 2017;220:2265-2276 pubmed publisher
    ..australis, and to examine whether the abundance and arrangement of superficial neuromasts (SNs) varied within and among populations. We found that the SNs of M...
  35. Flak J, Arble D, Pan W, Patterson C, Lanigan T, Goforth P, et al. A leptin-regulated circuit controls glucose mobilization during noxious stimuli. J Clin Invest. 2017;127:3103-3113 pubmed publisher circulating leptin concentrations reflect a negative energy balance, which augments sympathetic nervous system (SNS) activation in response to metabolically demanding emergencies...
  36. Faber C, Lauria G, Merkies I, Cheng X, Han C, Ahn H, et al. Gain-of-function Nav1.8 mutations in painful neuropathy. Proc Natl Acad Sci U S A. 2012;109:19444-9 pubmed publisher
    ..8 mutations enhance the channel's response to depolarization and produce hyperexcitability in DRG neurons. These observations suggest that mutations of Na(v)1.8 contribute to painful peripheral neuropathy. ..
  37. van den Berg N, Simon H, KleinJan G, Engelen T, Bunschoten A, Welling M, et al. First-in-human evaluation of a hybrid modality that allows combined radio- and (near-infrared) fluorescence tracing during surgery. Eur J Nucl Med Mol Imaging. 2015;42:1639-1647 pubmed publisher
    ..detect the fluorescence signal of the hybrid tracer ICG-(99m)Tc-nanocolloid was firstly determined ex vivo in (non)SNs samples obtained from 41 patients who underwent hybrid tracer-based SN biopsy in the head and neck or urogenital ..
  38. Ivy J, Drechsler M, Catterson J, Bodmer R, Ocorr K, Paululat A, et al. Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. PLoS ONE. 2015;10:e0134620 pubmed publisher
    ..The data place dKlf15 upstream of sns and Amnionless in a nephrocyte-restricted differentiation pathway and suggest dKlf15 expression is both necessary ..
  39. Vugts G, Maaskant Braat A, Voogd A, van Riet Y, Luiten E, Rutgers E, et al. Repeat sentinel node biopsy should be considered in patients with locally recurrent breast cancer. Breast Cancer Res Treat. 2015;153:549-56 pubmed publisher
    ..9 %) than SNB (28.4 %; P < 0.001). In 230 patients (80.1 %), the retrieved SN was tumor negative; 17 SNs (5.9 %) contained a micrometastasis and 29 (10.1 %) a macrometastasis...
  40. Segal D, Dhanyasi N, Schejter E, Shilo B. Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia. Dev Cell. 2016;38:291-304 pubmed publisher
    ..We therefore propose that the filopodia are necessary to prime the heterotypic adhesion process between the two cell types, possibly by recruiting the cell-adhesion molecule Sns to discrete patches on the myoblast cell surface.
  41. Pawar H, Balivada S, Kenney M. Does aging alter the molecular substrate of ionotropic neurotransmitter receptors in the rostral ventral lateral medulla? - A short communication. Exp Gerontol. 2017;91:99-103 pubmed publisher
    Aging alters sympathetic nervous system (SNS) regulation, although central mechanisms are not well understood...
  42. Motyl K, Beauchemin M, Barlow D, Le P, Nagano K, Treyball A, et al. A novel role for dopamine signaling in the pathogenesis of bone loss from the atypical antipsychotic drug risperidone in female mice. Bone. 2017;103:168-176 pubmed publisher inhibition of ?-adrenergic receptor activation with propranolol, suggesting the sympathetic nervous system (SNS) plays a pathological role...
  43. Chester A, Walthert S, Gallagher S, Anderson L, Stitely M. Patient-targeted Googling and social media: a cross-sectional study of senior medical students. BMC Med Ethics. 2017;18:70 pubmed publisher
    ..issue is patient-targeted Googling (PTG), which involves a healthcare professional using a social networking site (SNS) or publicly available search engine to find patient information online...
  44. Poulet C, Wettwer E, Grunnet M, Jespersen T, Fabritz L, Matschke K, et al. Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation. PLoS ONE. 2015;10:e0131432 pubmed publisher
    ..Expression of SCN8A and SCN10A was low in general, and lower in AF than in SR...
  45. Estacion M, Vohra B, Liu S, Hoeijmakers J, Faber C, Merkies I, et al. Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation. J Neurophysiol. 2015;114:1554-64 pubmed publisher
    ..7, which triggers reverse mode of NCX and contributes to Ca(2+) toxicity, and suggest subtype-specific blockade of Nav1.7 or inhibition of reverse NCX as strategies that might slow or prevent axon degeneration in small-fiber neuropathy. ..
  46. Atkinson C, Carter H, Naylor L, Dawson E, Marusic P, Hering D, et al. Opposing effects of shear-mediated dilation and myogenic constriction on artery diameter in response to handgrip exercise in humans. J Appl Physiol (1985). 2015;119:858-64 pubmed publisher
    ..of 30 min of elevated blood pressure, in the absence of changes in shear stress or sympathetic nervous system (SNS) activation, on conduit artery diameter...
  47. Nascimento A, Machado M, Gomes F, Vieira A, Goncalves de Albuquerque C, Lessa M, et al. Central Sympathetic Modulation Reverses Microvascular Alterations in a Rat Model of High-Fat Diet-Induced Metabolic Syndrome. Microcirculation. 2016;23:320-9 pubmed publisher
    The objective of this study was to investigate the role of the SNS on hemodynamic, metabolic, and microvascular alterations in a rat model of HFD-induced MS with salt supplementation...
  48. Smits M, Tonneijck L, Muskiet M, Hoekstra T, Kramer M, Diamant M, et al. Heart rate acceleration with GLP-1 receptor agonists in type 2 diabetes patients: an acute and 12-week randomised, double-blind, placebo-controlled trial. Eur J Endocrinol. 2017;176:77-86 pubmed oscillometric technique, systemic haemodynamics by finger photoplethysmography, sympathetic nervous system (SNS) activity by heart rate variability and arterial stiffness by applanation tonometry...
  49. Duszka K, Picard A, Ellero Simatos S, Chen J, Defernez M, Paramalingam E, et al. Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction. Sci Rep. 2016;6:36937 pubmed publisher
    ..Interestingly, under conditions of CR, iePPARγKO mice failed to activate their sympathetic nervous system (SNS) and increase CR-specific locomotor activity...
  50. Hu T, Dong J. Two new phases of monolayer group-IV monochalcogenides and their piezoelectric properties. Phys Chem Chem Phys. 2016;18:32514-32520 pubmed
    Two stable structural phases of the monolayer group-IV monochalcogenides GeS, GeSe, SnS and SnSe have been found using first-principles calculations, and will be called as A-MX and H-MX...
  51. Schiano Di Visconte M, Santoro G, Cracco N, Sarzo G, Bellio G, Brunner M, et al. Effectiveness of sacral nerve stimulation in fecal incontinence after multimodal oncologic treatment for pelvic malignancies: a multicenter study with 2-year follow-up. Tech Coloproctol. 2018;22:97-105 pubmed publisher
    To assess whether sacral nerve stimulation (SNS) is an effective treatment for severe fecal incontinence (FI) after radiotherapy (RT)/chemoRT (CRT) in combination with pelvic surgery...
  52. Yang Z, Yu Y, Chi J, Guan M, Zhao Y, Cao X. The combined pN stage and breast cancer subtypes in breast cancer: a better discriminator of outcome can be used to refine the 8th AJCC staging manual. Breast Cancer. 2018;25:315-324 pubmed publisher
    ..stage and then divided it into four groups: pN0new, pN1new, pN2new, and pN3new...
  53. Okubo K, Uenosono Y, Arigami T, Matsushita D, Yanagita S, Kijima T, et al. Quantitative assessment of fluorescence intensity of ICG in sentinel nodes in early gastric cancer. Gastric Cancer. 2018;21:776-781 pubmed publisher
    ..1% dissection of HNs. It is possible that the evaluation of fluorescence intensity is useful for selected SNs instead of RI tracer...
  54. Rath T, Gury L, Sanchez Molina I, Martinez L, Haque S. Formation of porous SnS nanoplate networks from solution and their application in hybrid solar cells. Chem Commun (Camb). 2015;51:10198-201 pubmed publisher
    ..we present a facile solution-based route towards nanostructured, hybrid absorber layers based on tin mono-sulfide (SnS), an emerging, non-toxic absorber material for low-cost and large-scale PV applications...
  55. Nguyen A, Lee N, Wee N, Zhang L, Enriquez R, Khor E, et al. Uncoupling protein-1 is protective of bone mass under mild cold stress conditions. Bone. 2018;106:167-178 pubmed publisher
    Brown adipose tissue (BAT), largely controlled by the sympathetic nervous system (SNS), has the ability to dissipate energy in the form of heat through the actions of uncoupling protein-1 (UCP-1), thereby critically influencing energy ..
  56. Zhang R, Cho S, Lim D, Hu X, Stach E, Handwerker C, et al. Metal-metal chalcogenide molecular precursors to binary, ternary, and quaternary metal chalcogenide thin films for electronic devices. Chem Commun (Camb). 2016;52:5007-10 pubmed publisher
    ..Thin-films of CuS, SnS, ZnS, Cu2Sn(S(x),Se(1-x))3, and Cu2ZnSn(S(x)Se(1-x))4 (0 ≤ x ≤ 1) were deposited using the as-dissolved ..
  57. Straub R, Ehrenstein B, Günther F, Rauch L, Trendafilova N, Boschiero D, et al. Increased extracellular water measured by bioimpedance and by increased serum levels of atrial natriuretic peptide in RA patients-signs of volume overload. Clin Rheumatol. 2017;36:1041-1051 pubmed publisher
    ..episodes such as infection stimulate water retention, chiefly implemented by the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis...
  58. Thompson C, Romo L. College Students' Drinking and Posting About Alcohol: Forwarding a Model of Motivations, Behaviors, and Consequences. J Health Commun. 2016;21:688-95 pubmed publisher
    ..In particular, espousing an alcohol identity predicted alcohol consumption and alcohol-related SNS posting, needing entertainment predicted alcohol consumption but not alcohol-related SNS posting, and adhering to ..
  59. Holterman L, Murray Close D, Breslend N. Relational victimization and depressive symptoms: The role of autonomic nervous system reactivity in emerging adults. Int J Psychophysiol. 2016;110:119-127 pubmed publisher
    ..influence the outcomes associated with victimization by peers, the moderating roles of sympathetic nervous system (SNS; as measured by skin conductance reactivity) and parasympathetic nervous system (PNS; as measured by respiratory ..
  60. Martelli G, Miceli R, Folli S, Guzzetti E, Chifu C, Maugeri I, et al. Sentinel node biopsy after primary chemotherapy in cT2 N0/1 breast cancer patients: Long-term results of a retrospective study. Eur J Surg Oncol. 2017;: pubmed publisher
    ..9%) given upfront AD; 139 (43.8%) given SNB + AD; and 77 (24.3%) given SNB only because the SNs were negative. After median follow-ups of 92 (AD), 99 (SNB + AD) and 72 months (SNB-only), OS (p = 0...
  61. Zhu T, Ding S, Li T, Zhu L, Huang X, Zhang X. Estrogen is an important mediator of mast cell activation in ovarian endometriomas. Reproduction. 2018;155:73-83 pubmed publisher
    ..Thus, elevated E2 concentrations may be a key factor for degranulation and recruitment of MCs in ovarian endometriomas, which play a key role in endometriosis-associated dysmenorrhea. ..
  62. Park S, Kim D, Jung H, Yun M, Lee J, Park C. Relationship Between the Size of Metastatic Lymph Nodes and Positron Emission Tomographic/Computer Tomographic Findings in Patients with Esophageal Squamous Cell Carcinoma. World J Surg. 2015;39:2948-54 pubmed publisher
    ..6 %) patients exhibited nodal metastasis and 59 (69.4 %) did not. Pathology grades of pN0, pN1, pN2, and pN3 were assigned to 45 (52.9 %), 24 (28.2 %), 13 (15.3 %), and 3 (3.5 %) patients, respectively...
  63. Frascaroli F, Bhagwat S, Guarino R, Chiarucci A, Schmid B. Shrines in Central Italy conserve plant diversity and large trees. Ambio. 2016;45:468-79 pubmed publisher
    Sacred natural sites (SNS) are instances of biocultural landscapes protected for spiritual motives...
  64. Jones J, Salazar L. A Review of HIV Prevention Studies that Use Social Networking Sites: Implications for Recruitment, Health Promotion Campaigns, and Efficacy Trials. AIDS Behav. 2016;20:2772-2781 pubmed
    This review describes the use of social networking sites (SNS) in the context of primary prevention of HIV. A review was conducted to assess the published literature for HIV interventions using SNS...
  65. Starzak D, Konkol K, McKune A. Effects of Cardiorespiratory Fitness and Obesity on Salivary Secretory IgA and Alpha-Amylase in South African Children. Children (Basel). 2016;3: pubmed publisher
    ..a mucosal immunity marker, and salivary alpha-amylase (sAA), a marker of stress-related sympathetic nervous system (SNS) activity, in South African children. Morning (7:30-8:00 a.m.) saliva samples were collected from 132 children (10...
  66. Greaney J, Kenney W. Measuring and quantifying skin sympathetic nervous system activity in humans. J Neurophysiol. 2017;118:2181-2193 pubmed publisher
    ..microneurography has substantially increased our understanding of the function of the sympathetic nervous system (SNS) in health and in disease...
  67. Zhu A, Qiao L, Jia Z, Tan P, Liu Y, Ma Y, et al. C-S bond induced ultrafine SnS2 dot/porous g-C3N4 sheet 0D/2D heterojunction: synthesis and photocatalytic mechanism investigation. Dalton Trans. 2017;46:17032-17040 pubmed publisher
    ..Herein, in situ of growing ultrafine SnS2 nanoparticles on a porous g-C3N4 sheet (SnS2/g-C3N4
  68. Wood J. Pathobiology of visceral pain: molecular mechanisms and therapeutic implications. II. Genetic approaches to pain therapy. Am J Physiol Gastrointest Liver Physiol. 2000;278:G507-12 pubmed
    ..and ion channels present in sensory neurons such as voltage-gated sodium channels [sensory neuron specific (SNS) and Na channel novel] and ATP-gated (P2X3), capsaicin-gated [vanilloid receptor 1(VR1)], and proton-gated [acid-..
  69. Alawi K, Aubdool A, Liang L, Wilde E, Vepa A, Psefteli M, et al. The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature. FASEB J. 2015;29:4285-98 pubmed publisher
    ..In the present study, we investigated whether TRPV1 modulates basal sympathetic nervous system (SNS) activity...
  70. Jia Z, Ren H, Li Q, Ji N, Luo F. Pulsed Radiofrequency Reduced Neuropathic Pain Behavior in Rats Associated with Upregulation of GDNF Expression. Pain Physician. 2016;19:49-58 pubmed
    ..The right SNs of the rats in the CS and CP groups were ligated to create a CCI model...
  71. Le C, Nowell C, Kim Fuchs C, Botteri E, Hiller J, Ismail H, et al. Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination. Nat Commun. 2016;7:10634 pubmed publisher
    Chronic stress induces signalling from the sympathetic nervous system (SNS) and drives cancer progression, although the pathways of tumour cell dissemination are unclear...
  72. Dias S, Gama A, Pingarilho M, Simões D, Mendão L. Health Services Use and HIV Prevalence Among Migrant and National Female Sex Workers in Portugal: Are We Providing the Services Needed?. AIDS Behav. 2017;21:2316-2321 pubmed publisher
    ..Un cuarto de las TS indocumentadas nunca utilizaron el Servicio Nacional de Salud (SNS) y el 15 % nunca fueron testadas respecto al VIH, porcentajes significativamente superiores a las observadas para ..
  73. Park J, Marvar P, Liao P, Kankam M, Norrholm S, Downey R, et al. Baroreflex dysfunction and augmented sympathetic nerve responses during mental stress in veterans with post-traumatic stress disorder. J Physiol. 2017;595:4893-4908 pubmed publisher
    ..Studies have suggested that PTSD patients have an overactive sympathetic nervous system (SNS) that could contribute to cardiovascular risk; however, sympathetic function has not previously been rigorously ..
  74. Meng D, Wang L, Du J, Chen J, Chen C, Xu W, et al. The analgesic activities of Stauntonia brachyanthera and YM11 through regulating inflammatory mediators and directly controlling the sodium channel prompt. Sci Rep. 2017;7:7574 pubmed publisher
    ..8 currents by 46.01% in small-diameter DRG neurons. Therefore, the analgesic activity of S. brachyanthera might be based on the regulation of inflammatory mediators and the directly control of the sodium channel prompt. ..
  75. Hernández K, Myers L, Bowser M, Kidd T. Genetic Tools for the Analysis of Drosophila Stomatogastric Nervous System Development. PLoS ONE. 2015;10:e0128290 pubmed publisher
    The Drosophila stomatogastric nervous system (SNS) is a compact collection of neurons that arises from the migration of neural precursors...
  76. Pucca M, Cerni F, Peigneur S, Bordon K, Tytgat J, Arantes E. Revealing the Function and the Structural Model of Ts4: Insights into the "Non-Toxic" Toxin from Tityus serrulatus Venom. Toxins (Basel). 2015;7:2534-50 pubmed publisher
    ..The absence of a Lys in the first amino acid residue of the N-terminal of Ts4 is probably the main responsible for its low toxicity. Other key amino acid residues important to the toxicity of α- and β-toxins are discussed here. ..
  77. Ye P, Hua L, Jiao Y, Li Z, Qin S, Fu J, et al. Functional up-regulation of Nav1.8 sodium channel on dorsal root ganglia neurons contributes to the induction of scorpion sting pain. Acta Biochim Biophys Sin (Shanghai). 2016;48:132-44 pubmed publisher
    ..8 in DRG. Our results suggest that functional up-regulation of Nav1.8 channel on DRG neurons contributes to the development of BmK I-induced pain in rats. ..
  78. Cruz Grecco Teixeira M, Martins G, Miranda Rodrigues M, De Araújo I, Oliveira R, Brum P, et al. Lack of α2C-Adrenoceptor Results in Contrasting Phenotypes of Long Bones and Vertebra and Prevents the Thyrotoxicosis-Induced Osteopenia. PLoS ONE. 2016;11:e0146795 pubmed publisher
    A series of studies have demonstrated that activation of the sympathetic nervous system (SNS) causes osteopenia via β2-adrenoceptor (β2-AR) signaling...
  79. van den Berg N, Engelen T, Brouwer O, Mathéron H, Valdes Olmos R, Nieweg O, et al. A pilot study of SPECT/CT-based mixed-reality navigation towards the sentinel node in patients with melanoma or Merkel cell carcinoma of a lower extremity. Nucl Med Commun. 2016;37:812-7 pubmed publisher
    ..cell carcinoma surgery is feasible and can provide the surgeon with an interactive 3D roadmap towards the SN or SNs in the groin...
  80. Jiang W, Li Y, Sun J, Li L, Li J, Zhang C, et al. Spleen contributes to restraint stress induced changes in blood leukocytes distribution. Sci Rep. 2017;7:6501 pubmed publisher
    ..We demonstrated that activation of hypothalamic-pituitary-adrenal axis (HPA) and sympathetic nervous system (SNS) contributes to restraint stress induced alteration of blood leukocyte distribution...
  81. Patel M, Kumar M, Kim J, Kim Y. Photocurrent Enhancement by a Rapid Thermal Treatment of Nanodisk-Shaped SnS Photocathodes. J Phys Chem Lett. 2017;: pubmed publisher
    Photocathodes made from the earth-abundant, eco-friendly mineral tin monosulfide (SnS) can be promising candidates for p/n-type photoelectrochemical cells, since they meet the strict requirements of energy band edges for each individual ..
  82. Zvan B, Zaletel M, Pretnar J, Pogacnik T, Kiauta T. Influence of the cold pressor test on the middle cerebral artery circulation. J Auton Nerv Syst. 1998;74:175-8 pubmed
    Cold pressor test (CPT) evokes generalized activation of the sympathetic nervous system (SNS)...
  83. Renganathan M, Cummins T, Waxman S. Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons. J Neurophysiol. 2001;86:629-40 pubmed
    ..8 (alpha-SNS) in action potential electrogenesis...
  84. Chiu C, Young S. The Relationship Between Online Social Network Use, Sexual Risk Behaviors, and HIV Sero-Status Among a Sample of Predominately African American and Latino Men Who have Sex with Men (MSM) Social Media Users. AIDS Behav. 2015;19 Suppl 2:98-105 pubmed publisher
    ..risk behaviors between HIV(+) and HIV(-) individuals among a sample of predominately African American and Latino SNS-using MSM. A total of 112 MSM Facebook users were recruited online and offline and completed an online survey...
  85. Shelke H, Lokhande A, Kim J, Lokhande C. Photoelectrochemical (PEC) studies on Cu2SnS3 (CTS) thin films deposited by chemical bath deposition method. J Colloid Interface Sci. 2017;506:144-153 pubmed publisher
    Cu2SnS3 (CTS) thin films have been successfully deposited on a cost-effective stainless steel substrate by simple and inexpensive chemical bath deposition (CBD) method...
  86. Chen K, Zhou J, Chen W, Zhong Q, Yang T, Yang X, et al. Growth kinetics and mechanisms of multinary copper-based metal sulfide nanocrystals. Nanoscale. 2017;9:12470-12478 pubmed publisher
    ..Herein, Cu-M-S NCs, including Cu2ZnSnS4 (CZTS), Cu2SnS3 (CTS), CuInS2 (CIS), and CuSbS2 (CAS), have been synthesized through solution-..
  87. Gonzalez O, Zafon C, Caubet E, García Burillo A, Serres X, Fort J, et al. Selective sentinel lymph node biopsy in papillary thyroid carcinoma in patients with no preoperative evidence of lymph node metastasis. Endocrinol Diabetes Nutr. 2017;64:451-455 pubmed publisher
    ..Forty-three patients, 34 females, with a mean age of 52.3 (±17) years, were enrolled. Forty-six (27%) of the 170 SNs resected from 24 (55.8%) patients were positive for metastasis. In addition, 94 (15...
  88. Howard L, Heron K, MacIntyre R, Myers T, Everhart R. Is use of social networking sites associated with young women's body dissatisfaction and disordered eating? A look at Black-White racial differences. Body Image. 2017;23:109-113 pubmed publisher
    Maladaptive patterns of social networking site (SNS) use, such as excessive reassurance seeking, are associated with body dissatisfaction and disordered eating...
  89. Rao G, Pell W, Gabidullin B, Korobkov I, Richeson D. Electro- and Photocatalytic Generation of H2 Using a Distinctive CoII "PN3 P" Pincer Supported Complex with Water or Saturated Saline as a Hydrogen Source. Chemistry. 2017;: pubmed publisher
  90. Cang C, Zhang H, Zhang Y, Zhao Z. PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons. Mol Pain. 2009;5:33 pubmed publisher
    ..These data suggest that activation of NK-1 receptor potentiates Na(v)1.8 sodium current via PKCepsilon-dependent signaling pathway, probably participating in the generation of inflammatory hyperalgesia. ..
  91. Bird E, Christmas C, Loescher A, Smith K, Robinson P, Black J, et al. Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas. Mol Pain. 2013;9:52 pubmed publisher
    ..These data provide further evidence that changes in expression of Nav1.8 are important in the development and/or maintenance of nerve injury-induced pain, and suggest that Nav1.8 may be a potential therapeutic target. ..
  92. Hong K, Lim J, Kim J, Tabara Y, Ueshima H, Miki T, et al. Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. Hum Mol Genet. 2014;23:6659-67 pubmed publisher
    ..In addition, C allele of rs17026156 increases PR interval (beta ± SE, 2.39 ± 0.40 ms) and exists far more frequently in East Asians (0.46) than in Europeans and Africans (0.05 and 0.08, respectively). ..