SAV1

Summary

Gene Symbol: SAV1
Description: salvador family WW domain containing protein 1
Alias: SAV, WW45, WWP4, protein salvador homolog 1, 1700040G09Rik, 45 kDa WW domain protein, WW domain-containing adaptor 45, hWW45, salvador homolog 1
Species: human
Products:     SAV1

Top Publications

  1. Tapon N, Harvey K, Bell D, Wahrer D, Schiripo T, Haber D, et al. salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell. 2002;110:467-78 pubmed
    ..Salvador contains two WW domains and binds to the Warts (or LATS) protein kinase. The human ortholog of salvador (hWW45) is mutated in three cancer cell lines...
  2. Zhang S, Zhou Y, Xu W, Tian L, Chen J, Chen S, et al. Impact of co-infections with enteric pathogens on children suffering from acute diarrhea in southwest China. Infect Dis Poverty. 2016;5:64 pubmed publisher
    ..Stool specimens were collected to detect five virus (rotavirus group A, RVA; norovirus, NoV; Sapovirus, SaV; astrovirus, As; and adenovirus, Ad), seven bacterial (diarrheagenic Escherichia coli, DEC; non-typhoidal ..
  3. Yang X, Cao X, He P, Li J, Feng M, Zhang Y, et al. Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis. Gastroenterology. 2018;155:1233-1249.e22 pubmed publisher
    ..RACGAP1 promotes proliferation of HCC cells by reducing activation of the Hippo and YAP pathways and promoting cytokinesis in coordination with TPR. ..
  4. Li Y, Yang F, Zhu C, Tang L. Effect and mechanism of RNAi targeting WWTR1 on biological activity of gastric cancer cells SGC7901. Mol Med Rep. 2017;: pubmed publisher
    ..In conclusion, WWTR1 promotes cell proliferation and inhibits apoptosis of GC cells by regulating cell cycle/apoptosis?associated factors, and effectors in the TGF?? pathway...
  5. Hussain T, Kil H, Hattiangady B, Lee J, Kodali M, Shuai B, et al. Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus. Neurobiol Dis. 2019;121:163-176 pubmed publisher
    ..This study provides the first genotype-phenotype observations as well as potential mechanistic clues associated with Wwox loss of function in the brain. ..
  6. Alfajaro M, Cho E, Kim D, Kim J, Park J, Soliman M, et al. Early Porcine Sapovirus Infection Disrupts Tight Junctions and Uses Occludin as a Coreceptor. J Virol. 2019;93: pubmed publisher
    ..This work contributes to our understanding of the entry of SaV and other caliciviruses into cells and may aid in the development of efficient and affordable drugs to treat SaV ..
  7. Johansen L, Thim H, Jørgensen S, Afanasyev S, Strandskog G, Taksdal T, et al. Comparison of transcriptomic responses to pancreas disease (PD) and heart and skeletal muscle inflammation (HSMI) in heart of Atlantic salmon (Salmo salar L). Fish Shellfish Immunol. 2015;46:612-23 pubmed publisher
    Pancreas disease (PD) and heart and skeletal muscle inflammation (HSMI) are viral diseases associated with SAV (salmonid alphavirus) and PRV (piscine reovirus), which induce systemic infections and pathologies in cardiac and skeletal ..
  8. Huang C, Tian Y, Peng R, Zhang C, Wang D, Han S, et al. Association of downregulation of WWOX with poor prognosis in patients with intrahepatic cholangiocarcinoma after curative resection. J Gastroenterol Hepatol. 2015;30:421-33 pubmed publisher
    ..Downregulation of WWOX may occur as a result of hypermethylation and implies a poor prognosis in ICC; WWOX re-expression may be a potential molecular therapeutic target for ICC. ..
  9. Liu J, Dong S, Li L, Wang H, Zhao J, Zhao Y. The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system. Cell Signal. 2019;58:91-98 pubmed publisher
    ..This study will provide a new direction to clarify the molecular regulation of TTF1 in lung and its role in lung epithelial remodeling after injury. ..

More Information

Publications143 found, 100 shown here

  1. Yang C, Lu W, Lin T, You P, Ye M, Huang Y, et al. Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol. 2013;13:67 pubmed publisher
    ..in response to chemical (DEN treatment) and genetic-induced hepatocarcinogenesis (disruptions in LKB1, p53, MST1/2, SAV1 and PTEN). It is also induced in response to loss of liver mass due to partial hepatectomy followed by regeneration...
  2. Yang H, Liang Y, Chen J, Chiang K, Chung C, Ho H, et al. Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study. PLoS ONE. 2012;7:e32907 pubmed publisher
    ..Identification of these genes enriches the collection of hypertension susceptibility genes, thereby shedding light on the etiology of hypertension in Han Chinese populations. ..
  3. Nie Z, Zheng Y, Du H, Xie S, Wang M. Dynamics and diversity of microbial community succession in traditional fermentation of Shanxi aged vinegar. Food Microbiol. 2015;47:62-8 pubmed publisher
    The traditional fermentation of Shanxi aged vinegar (SAV), a well-known traditional Chinese vinegar, generally involves the preparation of starter daqu, starch saccharification, alcoholic fermentation (AF) and acetic acid fermentation (..
  4. Purcell M, Powers R, Evered J, Kerwin J, Meyers T, Stewart B, et al. Molecular testing of adult Pacific salmon and trout (Oncorhynchus spp.) for several RNA viruses demonstrates widespread distribution of piscine orthoreovirus in Alaska and Washington. J Fish Dis. 2017;: pubmed publisher
    ..samples for ISAV RNA with three additional published molecular assays, as well as for RNA from salmonid alphavirus (SAV), piscine myocarditis virus (PMCV) and piscine orthoreovirus (PRV)...
  5. Bamdad F, Shin S, Suh J, Nimalaratne C, Sunwoo H. Anti-Inflammatory and Antioxidant Properties of Casein Hydrolysate Produced Using High Hydrostatic Pressure Combined with Proteolytic Enzymes. Molecules. 2017;22: pubmed publisher
    ..Casein was hydrolysed by different proteases, including flavourzyme (Fla), savinase (Sav), thermolysin (Ther), trypsin (Try), and elastase (Ela) at 0...
  6. Romalde J, Rivadulla E, Varela M, Barja J. An overview of 20 years of studies on the prevalence of human enteric viruses in shellfish from Galicia, Spain. J Appl Microbiol. 2017;: pubmed publisher
    ..agents norovirus (NoV) and hepatitis A virus (HAV), but also data on emerging viral hazards, including sapovirus (SaV), hepatitis E virus (HEV) and aichivirus (AiV)...
  7. Cajado Carvalho D, Kuniyoshi A, Kodama R, Oliveira A, Serrano S, Tambourgi D, et al. Neuropeptide Y family-degrading metallopeptidases in the Tityus serrulatus venom partially blocked by commercial antivenoms. Toxicol Sci. 2014;142:418-26 pubmed publisher
    ..Also, peptidase activities were only partially inhibited by therapeutic Brazilian scorpion antivenom (SAV) and arachnid antivenom (AAV)...
  8. Nyati K, Masuda K, Zaman M, Dubey P, Millrine D, Chalise J, et al. TLR4-induced NF-?B and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a. Nucleic Acids Res. 2017;45:2687-2703 pubmed publisher
    ..This study therefore substantially increases our understanding of the mechanisms by which IL-6 is regulated. ..
  9. Yang W, Wang X, Yuan H, Liu Z, Gao S, Peng L. Exploring the mechanism of WWOX growth inhibitory effects on oral squamous cell carcinoma. Oncol Lett. 2017;13:3198-3204 pubmed publisher
    ..These results suggest that the tumor-suppressor function of the WWOX gene may be associated with the modulation of the ERK/MAPK signaling pathway, thus providing a novel target for OSCC therapy. ..
  10. Nakamura N, Kobayashi S, Minagawa H, Matsushita T, Sugiura W, Iwatani Y. Molecular epidemiology of enteric viruses in patients with acute gastroenteritis in Aichi prefecture, Japan, 2008/09-2013/14. J Med Virol. 2016;88:1180-6 pubmed publisher
    ..2%), adenovirus (AdV) type 41 (8.2%), sapovirus (SaV) (3.6%), human astrovirus (HAstV) (2.8%), and NoV genogroup I (1.3%)...
  11. Lin J, Li H, Chang N, Lin C, Chen Y, Lu P. WWOX suppresses prostate cancer cell progression through cyclin D1-mediated cell cycle arrest in the G1 phase. Cell Cycle. 2015;14:408-16 pubmed publisher
    ..These results suggest that WWOX inhibits prostate cancer progression through negatively regulating cyclin D1 in cell cycle lead to G1 arrest. In summary, our data reveal a novel mechanism of WWOX in tumor suppression. ..
  12. Liu J, Li X, Zhang H, Gu R, Wang Z, Gao Z, et al. Ubiquitin E3 ligase Itch negatively regulates osteoblast function by promoting proteasome degradation of osteogenic proteins. Bone Joint Res. 2017;6:154-161 pubmed publisher
    ..Wang, Z. Gao, L. Xing. Ubiquitin E3 ligase Itch negatively regulates osteoblast function by promoting proteasome degradation of osteogenic proteins. Bone Joint Res 2017;6:154-161. DOI: 10.1302/2046-3758.63.BJR-2016-0237.R1. ..
  13. Kodama T, Yi J, Newberg J, Tien J, Wu H, Finegold M, et al. Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis. Proc Natl Acad Sci U S A. 2018;115:E10417-E10426 pubmed publisher
    ..Forty-one CCGs appeared specific for NAFLD-HCC, including Sav1, a component of the Hippo signaling pathway and the most frequently mutated gene identified in both NAFLD-HCC ..
  14. Valencia Sama I, Zhao Y, Lai D, Janse van Rensburg H, Hao Y, Yang X. Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor. J Biol Chem. 2015;290:16906-17 pubmed publisher
    ..Altogether, this study provides novel evidence that the Hippo component TAZ can function as a co-repressor and regulate biological functions by negatively regulating downstream cellular genes. ..
  15. Guo T, Johansson D, Liljeström P, Evensen Ã, Haugland Ã. Modification of a salmonid alphavirus replicon vector for enhanced expression of heterologous antigens. J Gen Virol. 2015;96:565-70 pubmed publisher
    A salmonid alphavirus (SAV) replicon has been developed to express heterologous antigens but protein production was low to modest compared with terrestrial alphavirus replicons...
  16. Lo J, Chou Y, Lai F, Hsu L. Regulation of cell signaling and apoptosis by tumor suppressor WWOX. Exp Biol Med (Maywood). 2015;240:383-91 pubmed publisher
  17. Lekana Douki S, Kombila Koumavor C, Nkoghe D, Drosten C, Drexler J, Leroy E. Molecular epidemiology of enteric viruses and genotyping of rotavirus A, adenovirus and astrovirus among children under 5 years old in Gabon. Int J Infect Dis. 2015;34:90-5 pubmed publisher
    ..6%), Norovirus II (NoVs-II) (13.9%), Norovirus I (NoVs-I) (9.1%), Sapovirus (SaV) (9.5%) and human Astrovirus (HAstV) (6.3%). One-third of the 193 positive samples contained more than one virus...
  18. Hikke M, Geertsema C, Wu V, Metz S, van Lent J, Vlak J, et al. Alphavirus capsid proteins self-assemble into core-like particles in insect cells: A promising platform for nanoparticle vaccine development. Biotechnol J. 2016;11:266-73 pubmed publisher
    ..chikungunya virus (CHIKV) causes arthritic diseases in humans, whereas the aquatic salmonid alphavirus (SAV) is associated with high mortality in aquaculture of salmon and trout...
  19. Oka T, Doan Y, Shimoike T, Haga K, Takizawa T. First complete genome sequences of genogroup V, genotype 3 porcine sapoviruses: common 5'-terminal genomic feature of sapoviruses. Virus Genes. 2017;53:848-855 pubmed publisher
    ..In this study, we determined the first complete genome sequences of two genogroup V, genotype 3 (GV.3) SaV strains detected from swine fecal samples, in combination with Illumina MiSeq sequencing of the libraries prepared ..
  20. Huang C, Huang M, Chung H, Chiu S, Yadav P, Lin Y, et al. Impaired mammary tumor formation and metastasis by the point mutation of a Smad3 linker phosphorylation site. Biochim Biophys Acta Mol Basis Dis. 2018;1864:3664-3671 pubmed publisher
    ..Our results using gene editing indicate the cancer-promoting role of Smad3 T179 phosphorylation in the human TNBC cells. Our findings highly suggest that controlling this phosphorylation may have therapeutic potential for TNBC. ..
  21. Chang N. Bubbling cell death: A hot air balloon released from the nucleus in the cold. Exp Biol Med (Maywood). 2016;241:1306-15 pubmed publisher
    ..In this mini-review, updated knowledge in cell death and the proposed molecular mechanism for BCD are provided. ..
  22. Moore L, Jarungsriapisit J, Nilsen T, Stefansson S, Taranger G, Secombes C, et al. Immune gene profiles in Atlantic salmon (salmo salar L.) post-smolts infected with SAV3 by bath-challenge show a delayed response and lower levels of gene transcription compared to injected fish. Fish Shellfish Immunol. 2017;62:320-331 pubmed publisher
    Salmonid alphavirus (SAV) causes pancreatic disease (PD) in salmonids in Northern Europe which results in large economic losses within the aquaculture industry...
  23. Snow M. The contribution of molecular epidemiology to the understanding and control of viral diseases of salmonid aquaculture. Vet Res. 2011;42:56 pubmed publisher
    ..fish of commercial significance including viral haemorrhagic septicaemia virus (VHSV), salmonid alphavirus (SAV) and infectious salmon anaemia virus (ISAV)...
  24. Lemes L, Corrêa T, Fiaccadori F, Cardoso D, Arantes A, Souza K, et al. Prospective study on Norovirus infection among allogeneic stem cell transplant recipients: prolonged viral excretion and viral RNA in the blood. J Clin Virol. 2014;61:329-33 pubmed publisher
    ..Ten ASCT patients were monitored for NoV and sapoviruses (SaV) infection, for a period of five months to a maximum of one year...
  25. Trop J, Gendenjamts B, Bat Erdene U, Doripurev D, Ganbold S, Bayalag M, et al. Postpartum depression in Mongolia: A qualitative exploration of health care providers' perspectives. Midwifery. 2018;65:18-25 pubmed publisher
    ..A traditional concept of PPD ("sav khuurukh") was prominently mentioned...
  26. Yan H, Xu J, Fang L, Qiu Y, Lin X, Huang H, et al. Ectopic expression of the WWOX gene suppresses stemness of human ovarian cancer stem cells. Oncol Lett. 2015;9:1614-1620 pubmed
  27. Nourashrafeddin S, Aarabi M, Modarressi M, Rahmati M, Nouri M. The Evaluation of WBP2NL-Related Genes Expression in Breast Cancer. Pathol Oncol Res. 2015;21:293-300 pubmed publisher
    ..These findings lead us to suggest that WBP2NL might play roles as an anti-apoptotic factor or co-activator to promote breast cancer cell survival and proliferation. ..
  28. Nie Z, Zheng Y, Xie S, Zhang X, Song J, Xia M, et al. Unraveling the correlation between microbiota succession and metabolite changes in traditional Shanxi aged vinegar. Sci Rep. 2017;7:9240 pubmed publisher
    Shanxi aged vinegar (SAV) is a well-known vinegar produced by traditional solid-state fermentation and has been used in China for thousands of years...
  29. Zeruth G, Williams J, Cole Y, Jetten A. HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. PLoS ONE. 2015;10:e0131303 pubmed publisher
  30. Yinda C, Conceição Neto N, Zeller M, Heylen E, Maes P, Ghogomu S, et al. Novel highly divergent sapoviruses detected by metagenomics analysis in straw-colored fruit bats in Cameroon. Emerg Microbes Infect. 2017;6:e38 pubmed publisher
    ..Nearly complete genome sequences of six highly divergent SaVs and one partial SaV (only VP1 region) were identified in Eidolon helvum and based on sequence identities and phylogenetic analysis, ..
  31. Jarungsriapisit J, Moore L, Mæhle S, Skår C, Einen A, Fiksdal I, et al. Relationship between viral dose and outcome of infection in Atlantic salmon, Salmo salar L., post-smolts bath-challenged with salmonid alphavirus subtype 3. Vet Res. 2016;47:102 pubmed
    ..These data also confirm the highly infectious nature of SAV through horizontal transmission...
  32. Valente C, Alfieri A, Barry A, Leme R, Lorenzetti E, Alfieri A. Age distribution of porcine sapovirus asymptomatic infection and molecular evidence of genogroups GIII and GIX? circulation in distinct Brazilian pig production systems. Trop Anim Health Prod. 2016;48:21-7 pubmed publisher
    This study aimed to evaluate the natural infection by SaV in pigs of different categories of production cycle in an important Brazilian pig-producing region...
  33. Chung S, Brown E, Williams A, Ramos P, Berthier C, Bhangale T, et al. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. J Am Soc Nephrol. 2014;25:2859-70 pubmed publisher
    ..Results from this large-scale genome-wide investigation of lupus nephritis provide evidence of multiple biologically relevant lupus nephritis susceptibility loci. ..
  34. Xu S, Qin Y, Pan D, Ye G, Wu C, Wang S, et al. Inhibition of WWP2 suppresses proliferation, and induces G1 cell cycle arrest and apoptosis in liver cancer cells. Mol Med Rep. 2016;13:2261-6 pubmed publisher
    ..Furthermore, WWP2 may represent a novel diagnostic marker and molecular therapeutic target for liver cancer. ..
  35. Tsai T, Li C, Livneh H, Lin I, Lu M, Yeh C. Decreased risk of stroke in patients receiving traditional Chinese medicine for vertigo: A population-based cohort study. J Ethnopharmacol. 2016;184:138-43 pubmed publisher
    ..Benth. & Hook.f. ex Franch. & Sav., root), Ge Gen (Pueraria lobata (Willd...
  36. Yuan L, Li Z. [Research advances in the role of the Hippo signaling pathway in pathogenesis of liver cancer]. Zhonghua Gan Zang Bing Za Zhi. 2017;25:797-800 pubmed publisher
    The Hippo signaling pathway consists of four core components in mammals, i.e., Mst1/2, WW45, Mob1, and LATS1/2, which can inhibit the transcriptional coactivator YAP from entering the nucleus, maintain the balance between cell ..
  37. Staley C, Reckhow K, Lukasik J, Harwood V. Assessment of sources of human pathogens and fecal contamination in a Florida freshwater lake. Water Res. 2012;46:5799-5812 pubmed publisher
    ..We hypothesized that submerged aquatic vegetation (SAV), sediments, and stormwater act as reservoirs and/or provide inputs of FIB and human pathogens to this inland water...
  38. Zhang X, Chao J, Pan Q, Pan K, Weng D, Wang Q, et al. Overexpression of WWP1 promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma. Oncotarget. 2015;6:40920-33 pubmed publisher
    ..Our findings suggest that WWP1 might have an oncogenic role in human primary HCC, and that it could be used as a prognostic marker as well as a potential molecular target for the treatment of HCC. ..
  39. Choi H, Park J, Park J, Lee K, Oh S. Pc2-mediated SUMOylation of WWOX is essential for its suppression of DU145 prostate tumorigenesis. FEBS Lett. 2015;589:3977-88 pubmed publisher
    ..Collectively, our findings demonstrate that SUMO modification of WWOX is essential for its suppressive activity for DU145 prostate cancer tumorigenesis. ..
  40. Jarungsriapisit J, Moore L, Taranger G, Nilsen T, Morton H, Fiksdal I, et al. Atlantic salmon (Salmo salar L.) post-smolts challenged two or nine weeks after seawater-transfer show differences in their susceptibility to salmonid alphavirus subtype 3 (SAV3). Virol J. 2016;13:66 pubmed publisher
    Pancreas disease (PD), caused by salmonid alphavirus (SAV), is an important disease affecting salmonid aquaculture...
  41. Kim H, Kim M, Park Y, Park I, Kim T, Yang S, et al. Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice. Gastroenterology. 2017;152:616-630 pubmed publisher
    ..mice were crossed with mice with intestine-specific disruption of the salvador family WW domain containing 1 gene (Sav1), which encodes an activator of Hippo signaling...
  42. Esseili M, Chin A, Saif L, Miller S, Qu F, Lewis Ivey M, et al. Postharvest Survival of Porcine Sapovirus, a Human Norovirus Surrogate, on Phytopathogen-Infected Leafy Greens. J Food Prot. 2015;78:1472-80 pubmed publisher
    ..The survival rate of porcine sapovirus (SaV), a HuNoV surrogate, on infected and noninfected postharvest leaves was then assessed...
  43. Martin C, Sun W. Comparison of transcatheter aortic valve and surgical bioprosthetic valve durability: A fatigue simulation study. J Biomech. 2015;48:3026-34 pubmed publisher
    ..is associated with lower operative risk and shorter recovery times than traditional surgical aortic valve (SAV) replacement, TAV intervention is still not considered for lower-risk patients due in part to concerns about device ..
  44. Huang S, Su W, Lin H, Kuo H, Wei H, Chang N. Role of WW Domain-containing Oxidoreductase WWOX in Driving T Cell Acute Lymphoblastic Leukemia Maturation. J Biol Chem. 2016;291:17319-31 pubmed publisher
    ..Meanwhile, a portion of ERK and WWOX relocates to the nucleus, suggesting their role in the induction of CD3 and CD8 expression in MOLT-4. ..
  45. Schuster I, Krahé B, Toplu Demirtaş E. Prevalence of Sexual Aggression Victimization and Perpetration in a Sample of Female and Male College Students in Turkey. J Sex Res. 2016;53:1139-1152 pubmed
    ..and sexual acts were measured with a Turkish version of the Sexual Aggression and Victimization Scale (SAV-S). Overall, 77.6% of women and 65...
  46. Yi J, Lu L, Yanger K, Wang W, Sohn B, Stanger B, et al. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology. 2016;64:1757-1772 pubmed publisher
    ..These findings suggest that dynamic regulation of the Hippo signaling pathway plays an important role in differentiation and functional maturation of the liver. (Hepatology 2016;64:1757-1772). ..
  47. Varela M, Monteiro S, Rivadulla E, Santos R, Romalde J. Development of a novel digital RT-PCR method for detection of human sapovirus in different matrices. J Virol Methods. 2018;254:21-24 pubmed publisher
    A new nanofluidic digital RT-PCR method was developed for sapovirus (SaV) using control material obtained according to standards for enteric viruses...
  48. Esseili M, Saif L, Farkas T, Wang Q. Feline Calicivirus, Murine Norovirus, Porcine Sapovirus, and Tulane Virus Survival on Postharvest Lettuce. Appl Environ Microbiol. 2015;81:5085-92 pubmed publisher
    ..HuNoV cannot be routinely cultured, culturable feline calicivirus (FCV), murine norovirus (MNV), porcine sapovirus (SaV), and Tulane virus (TV) have been used as surrogates...
  49. Abu Remaileh M, Joy Dodson E, Schueler Furman O, Aqeilan R. Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells. J Biol Chem. 2015;290:30728-35 pubmed publisher
    ..Here we present a short overview of the various approaches taken to study this dynamic gene, emphasizing the most recent findings regarding WWOX's metabolic- and CNS-associated functions and their underlying molecular basis. ..
  50. Sisay Z, Djikeng A, Berhe N, Belay G, Gebreyes W, Abegaz W, et al. Prevalence and molecular characterization of human noroviruses and sapoviruses in Ethiopia. Arch Virol. 2016;161:2169-82 pubmed publisher
    ..Of the clinical samples, 25.3 % and 4.2 % were positive for NoV and SaV RNA, respectively...
  51. Wang L, Wang Y, Li P, Wang R, Zhu Y, Zheng F, et al. Expression profile and prognostic value of SAV1 in patients with pancreatic ductal adenocarcinoma. Tumour Biol. 2016;: pubmed
    b>SAV1 is a human homolog of salvador that contains two protein-protein interaction modules known as WW domains and acts as a scaffolding protein for Hpo and Warts...
  52. Tong W, Yang L, Yu Q, Yao J, He A. A new tumor suppressor lncRNA RP11-190D6.2 inhibits the proliferation, migration, and invasion of epithelial ovarian cancer cells. Onco Targets Ther. 2017;10:1227-1235 pubmed publisher
    ..The analyses in EOC implicate that RP11-190D6.2 may play a pivotal role in the regulation of tumor metastasis, suggesting that RP11-190D6.2 may serve as a potential biomarker and therapeutic target for EOC. ..
  53. Hu C, Wu H, Su Y, Lin C, Chang C, Wu C. Evodiamine Exerts an Anti-Hepatocellular Carcinoma Activity through a WWOX-Dependent Pathway. Molecules. 2017;22: pubmed publisher
    ..As such, evodiamine activated WWOX to exert an anti-HCC activity, and might be a potential therapeutic or preventive candidate for HCC treatment. ..
  54. Xu M, Xiao J, Chen M, Yuan L, Li J, Shen H, et al. miR?149?5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway. Int J Oncol. 2018;52:815-827 pubmed publisher
    ..core kinase components of the Hippo signaling pathway, STE20-like kinase (MST)1 and protein salvador homolog 1 (SAV1), resulting in the inactivation of TEA domain (TEAD) transcription...
  55. Liu X, Yamamoto D, Saito M, Imagawa T, Ablola A, Tandoc A, et al. Molecular detection and characterization of sapovirus in hospitalized children with acute gastroenteritis in the Philippines. J Clin Virol. 2015;68:83-8 pubmed publisher
    Human sapovirus (SaV) is a causative agent of acute gastroenteritis. Recently, SaV detection has been increasing worldwide due to the emerging SaV genotype I.2. However, SaV infection has not been reported in the Philippines...
  56. Yoneda M, Nakano M, Sugimoto D, Inada M, Fujitani M, Kitahori Y. Epidemiological Characteristics of Sapovirus and Human Astrovirus Detected among Children in Nara Prefecture, Japan, during the 2009/2010-2014/2015 Seasons. Jpn J Infect Dis. 2017;70:87-91 pubmed publisher
    The current study elucidated the epidemiological characteristics of sapovirus (SaV) and human astrovirus (HAstV) associated with gastroenteritis among children in regional populations of Nara Prefecture, Japan, during the 2009/2010-2014/..
  57. Li G, Sun L, Mu Z, Huang Y, Fu C, Hu B. Ectopic WWOX Expression Inhibits Growth of 5637 Bladder Cancer Cell In Vitro and In Vivo. Cell Biochem Biophys. 2015;73:417-425 pubmed publisher
  58. Shi W, Song A, Gao S, Wang Y, Tang L, Xu Y, et al. Rapid and sensitive detection of salmonid alphavirus using TaqMan real-time PCR. Mol Cell Probes. 2017;34:13-20 pubmed publisher
    Salmonid alphavirus (SAV) infection has led to the spread of salmon pancreas disease (PD) and sleeping disease (SD) to salmonids in several countries in Europe, resulting in tremendous economic losses to the fish farming industry...
  59. Wiik Nielsen J, Alarcon M, Jensen B, Haugland Ø, Mikalsen A. Viral co-infections in farmed Atlantic salmon, Salmo salar L., displaying myocarditis. J Fish Dis. 2016;39:1495-1507 pubmed publisher
    ..In this study, we investigated the presence of PMCV, SAV, PRV and the recently identified Atlantic salmon calicivirus (ASCV), alone and as co-infections in farmed Atlantic ..
  60. Khamrin P, Kumthip K, Supadej K, Thongprachum A, Okitsu S, Hayakawa S, et al. Noroviruses and sapoviruses associated with acute gastroenteritis in pediatric patients in Thailand: increased detection of recombinant norovirus GII.P16/GII.13 strains. Arch Virol. 2017;162:3371-3380 pubmed publisher
    ..Out of 889 fecal specimens, 154 (17.3%) and 6 (0.7%) were positive for NoV GII isolates and SaV, respectively. Among the NoV GII, 10 different genotypes were identified with genotype GII...
  61. Fernandez M, Gardinali P. Risk assessment of triazine herbicides in surface waters and bioaccumulation of Irgarol and M1 by submerged aquatic vegetation in Southeast Florida. Sci Total Environ. 2016;541:1556-1571 pubmed publisher
    ..All SAV species collected revealed Irgarol bioaccumulation capabilities and a 90th centile bioconcentration factor (BCF) of ..
  62. Zhou X, Lei Q. Regulation of TAZ in cancer. Protein Cell. 2016;7:548-61 pubmed publisher
    ..We discuss here the regulators and regulation of TAZ. We also highlight the tumorigenic roles of TAZ and its potential therapeutic impact in human cancers. ..
  63. Bonnaire F, Goepel M, Bula P. [The new treatment procedure of the German statutory accident insurance: From the perspective of a community hospital]. Unfallchirurg. 2016;119:908-914 pubmed
    ..The implementation of the certification of hospitals for the very severe injury procedure (SAV) by the DGUV should have been completed by 2014...
  64. Chesarino N, McMichael T, Yount J. E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3. PLoS Pathog. 2015;11:e1005095 pubmed publisher
    ..Overall, this work identifies the enzyme NEDD4 as a new therapeutic target for the prevention of influenza virus infections, and introduces a new paradigm for up-regulating cellular levels of IFITM3 independently of IFN or infection. ..
  65. Yamaji K, Nagata S, Haruma T, Ohnuki T, Kozaki T, Watanabe N, et al. Root endophytic bacteria of a (137)Cs and Mn accumulator plant, Eleutherococcus sciadophylloides, increase (137)Cs and Mn desorption in the soil. J Environ Radioact. 2016;153:112-119 pubmed publisher
    ..We selected an endemic Japanese deciduous tree, Eleutherococcus sciadophylloides (Franch. et Sav), that accumulates high concentrations of (137)Cs and Mn. Root endophytic bacteria were isolated from E...
  66. Vahidkhah K, Javani S, Abbasi M, Azadani P, Tandar A, Dvir D, et al. Blood Stasis on Transcatheter Valve Leaflets and Implications for Valve-in-Valve Leaflet Thrombosis. Ann Thorac Surg. 2017;104:751-759 pubmed publisher
    ..thrombosis by quantifying the blood stasis on the noncoronary and coronary leaflets of a surgical aortic valve (SAV) and a transcatheter aortic valve (TAV) in a ViV setting...
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    ..e., norovirus and sapovirus). We detected Sapovirus (SaV), group I Norovirus (NoV GI) and group II Norovirus (NoV GII) from the stool samples of AGE cases...
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    ..A total of 192 fecal specimens previously screened for RV, ADV, NoV, HPeV and SaV, were tested for MWPyV with Taqman real time PCR. The most commonly detected virus was NoV GII (33...
  69. Cai J, Maitra A, Anders R, Taketo M, Pan D. β-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Genes Dev. 2015;29:1493-506 pubmed publisher
    ..We show that APC functions as a scaffold protein that facilitates the Hippo kinase cascade by interacting with Sav1 and Lats1...
  70. Zhu G, Wang Y, Mijiti M, Wang Z, Wu P, Jiafu D. Upregulation of miR-130b enhances stem cell-like phenotype in glioblastoma by inactivating the Hippo signaling pathway. Biochem Biophys Res Commun. 2015;465:194-9 pubmed publisher
    ..protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), to a low level of activity by the MST1-SAV1 complex-induced kinase cascade...
  71. Kang C, Koo H, An G, Choe Y, Choi J, Lee K, et al. Hybrid PET/optical imaging of integrin αVβ3 receptor expression using a (64)Cu-labeled streptavidin/biotin-based dimeric RGD peptide. EJNMMI Res. 2015;5:60 pubmed publisher
    ..Herein, we developed a (64)Cu-labeled AlexaFluor 680-streptavidin ((AF)SAv)/biotin-based dimeric cyclic RGD peptide (RGD2) for hybrid PET/optical imaging of integrin αVβ3 expression...
  72. Wang Y, Zhang J, Shen Z. The impact of calicivirus mixed infection in an oyster-associated outbreak during a food festival. J Clin Virol. 2015;73:55-63 pubmed publisher
    ..4 Sydney_2012, GII.13, GI.2, GI.5 and sapovirus (SaV) GI...
  73. Sisay Z, Djikeng A, Berhe N, Belay G, Abegaz W, Wang Q, et al. First detection and molecular characterization of sapoviruses and noroviruses with zoonotic potential in swine in Ethiopia. Arch Virol. 2016;161:2739-47 pubmed publisher
    ..1 and the other two as porcine SaV GIII...
  74. Aldabbagh S, Eckerle I, Müller A, Delwart E, Eis Hübinger A. Salivirus type 1 and type 2 in patients with acute gastroenteritis, Germany. J Clin Virol. 2015;72:16-9 pubmed publisher
    Salivirus (SaV-A) is a novel member of the family Picornaviridae and has been associated with acute gastroenteritis. Recently, a second type of SaV-A, SaV-A2, was identified in a sewage sample from Bangkok, Thailand...
  75. Lund M, Røsæg M, Krasnov A, Timmerhaus G, Nyman I, Aspehaug V, et al. Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar). Vet Res. 2016;47:107 pubmed
    ..inflammation (HSMI) caused by Piscine orthoreovirus (PRV), and pancreas disease (PD) caused by Salmonid alphavirus (SAV). Both PRV and SAV target heart and skeletal muscles, but SAV additionally targets exocrine pancreas...
  76. Janse van Rensburg H, Azad T, Ling M, Hao Y, Snetsinger B, Khanal P, et al. The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1. Cancer Res. 2018;78:1457-1470 pubmed publisher
    ..b>Significance: Human-specific activation of PD-L1 by a novel Hippo signaling pathway in cancer immune evasion may have a significant impact on research in immunotherapy. Cancer Res; 78(6); 1457-70. ©2018 AACR. ..
  77. Bunai K, Okubo H, Hano K, Inoue K, Kito Y, Saigo C, et al. TMEM207 hinders the tumour suppressor function of WWOX in oral squamous cell carcinoma. J Cell Mol Med. 2018;22:1026-1033 pubmed publisher
    ..As a whole, our findings indicate that the aberrant expression of TMEM207 contributes to tumour progression in OSCC, possibly via promoting aerobic glycolysis. ..
  78. Elbediwy A, Vincent Mistiaen Z, Spencer Dene B, Stone R, Boeing S, Wculek S, et al. Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development. 2016;143:1674-87 pubmed publisher
    ..differentiate an apical domain that recruits CRB3, Merlin (also known as NF2), KIBRA (also known as WWC1) and SAV1 to induce Hippo signalling and retain YAP/TAZ in the cytoplasm despite contact with the basal layer extracellular ..
  79. Mehra R, Vats P, Cieslik M, Cao X, Su F, Shukla S, et al. Biallelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney. Cancer Discov. 2016;6:1258-1266 pubmed
    ..PTPN14 (31%) and NF2 (22%) were the most commonly implicated Hippo pathway genes, whereas other genes such as SAV1 and HIPK2 were also involved in a mutually exclusive fashion...
  80. Strobel E, Watters K, Nedialkov Y, Artsimovitch I, Lucks J. Distributed biotin-streptavidin transcription roadblocks for mapping cotranscriptional RNA folding. Nucleic Acids Res. 2017;45:e109 pubmed publisher
    ..the broad applicability of cotranscriptional SHAPE-Seq by developing a sequence-independent biotin-streptavidin (SAv) roadblocking strategy that simplifies the preparation of roadblocking DNA templates...
  81. Urry D, Urry K, Szaflarski W, Nowicki M, Zabel M. Function and frustration of multi-drug ABC exporter protein and design of model proteins for drug delivery using protein hydration thermodynamics. Curr Pharm Des. 2009;15:2833-67 pubmed
    ..whereby simultaneous hydrolysis of two molecules of ATP in the ATP-binding cassette (ABC) exporter protein, Sav 1866, opens a transmembrane channel to pump drug out of the cell and confers drug resistance, e.g...
  82. Luo X, Li Z, Yan Q, Li X, Tao D, Wang J, et al. The human WW45 protein enhances MST1-mediated apoptosis in vivo. Int J Mol Med. 2009;23:357-62 pubmed
    ..Using a yeast two-hybrid system, we identified human WW45 (hWW45, also called hSav1) as an MST1-binding protein...
  83. Chen L, Yang H, Yu C, Yuan M, Li H. High hepatic exposure of furanocoumarins in Radix Angelica dahuricae is associated with transporter mediated active uptake. J Ethnopharmacol. 2018;212:74-85 pubmed publisher
    Radix Angelica dahuricae (RAD), the roots of Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav, is a well-known traditional Chinese medicine (TCM) and has been used for centuries to treat headaches, toothaches, nose ..
  84. Matsuura K, Nakada C, Mashio M, Narimatsu T, Yoshimoto T, Tanigawa M, et al. Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma. BMC Cancer. 2011;11:523 pubmed publisher
    ..In the present study, we found that SAV1 was significantly downregulated with copy number loss in high-grade ccRCCs...
  85. Li X, Luo X, Li Z, Wang G, Xiao H, Tao D, et al. Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system. Mol Biol Rep. 2012;39:8225-30 pubmed publisher
    ..We also confirmed the interaction of HAX-1 and hSav1 in mammalian cells. This investigation provides functional clues for further exploration of potential apoptosis-related proteins in disease biotherapy. ..
  86. Johansen A, Molenaar B, Versteeg D, Leitoguinho A, Demkes C, Spanjaard B, et al. Postnatal Cardiac Gene Editing Using CRISPR/Cas9 With AAV9-Mediated Delivery of Short Guide RNAs Results in Mosaic Gene Disruption. Circ Res. 2017;121:1168-1181 pubmed publisher
    ..proof-of-concept, we delivered short guide RNAs targeting 3 genes critical for cardiac physiology, Myh6, Sav1, and Tbx20, using a cardiotropic adeno-associated viral vector 9...
  87. Bae S, Ni L, Osinski A, Tomchick D, Brautigam C, Luo X. SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK. elife. 2017;6: pubmed publisher
    ..The scaffold protein SAV1 promotes the activation of this kinase cascade, but the molecular mechanisms remain unknown...
  88. Donninger H, Allen N, Henson A, Pogue J, Williams A, Gordon L, et al. Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions. J Biol Chem. 2011;286:18483-91 pubmed publisher
    ..Thus, we confirm a role for Salvador as a human tumor suppressor and RASSF1A effector and show that Salvador allows RASSF1A to modulate p73 independently of the hippo pathway. ..
  89. Luo X, Li Z, Li X, Wang G, Liu W, Dong S, et al. hSav1 interacts with HAX1 and attenuates its anti-apoptotic effects in MCF-7 breast cancer cells. Int J Mol Med. 2011;28:349-55 pubmed publisher
    ..However, the function of its human ortholog hSav1 (also called hWW45) in mammalian cells is poorly understood...
  90. Shaffer J, Polk D, Wang X, Feingold E, Weeks D, Lee M, et al. Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years. G3 (Bethesda). 2014;4:307-14 pubmed publisher
    ..Though small, efforts such this are needed in order to nominate novel genes and generate new hypotheses for exploration and testing in future studies. ..
  91. O Leary V, Smida J, Buske F, Carrascosa L, Azimzadeh O, Maugg D, et al. PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome. Sci Rep. 2017;7:7163 pubmed publisher
    ..These findings provide a mechanistic explanation for the ability of lncRNAs to regulate the expression of numerous genes distributed across the genome. ..
  92. Kuroda M, Masuda T, Ito M, Naoi Y, Doan Y, Haga K, et al. Genetic diversity and intergenogroup recombination events of sapoviruses detected from feces of pigs in Japan. Infect Genet Evol. 2017;55:209-217 pubmed publisher
    Sapoviruses (SaV) are enteric viruses infecting humans and animals. SaVs are highly diverse and are divided into multiple genogroups based on structural protein (VP1) sequences...