SATB2

Summary

Gene Symbol: SATB2
Description: SATB homeobox 2
Alias: GLSS, DNA-binding protein SATB2, SATB family member 2, special AT-rich sequence-binding protein 2
Species: human
Products:     SATB2

Top Publications

  1. Gyorgy A, Szemes M, de Juan Romero C, Tarabykin V, Agoston D. SATB2 interacts with chromatin-remodeling molecules in differentiating cortical neurons. Eur J Neurosci. 2008;27:865-73 pubmed publisher
    ..Here we investigated whether the regulatory function of SATB2 involves chromatin remodeling at the AT-rich DNA site...
  2. Dobreva G, Dambacher J, Grosschedl R. SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression. Genes Dev. 2003;17:3048-61 pubmed
    ..Here we characterize a novel cell type-specific MAR-binding protein, SATB2, which binds to the MARs of the endogenous immunoglobulin micro locus in pre-B cells and enhances gene expression...
  3. Leoyklang P, Suphapeetiporn K, Siriwan P, Desudchit T, Chaowanapanja P, Gahl W, et al. Heterozygous nonsense mutation SATB2 associated with cleft palate, osteoporosis, and cognitive defects. Hum Mutat. 2007;28:732-8 pubmed
    Studies of human chromosomal aberrations and knockout (KO) mice have suggested SATB2 as a candidate gene for a human malformation syndrome of craniofacial patterning and brain development...
  4. Rosenfeld J, Ballif B, Lucas A, Spence E, Powell C, Aylsworth A, et al. Small deletions of SATB2 cause some of the clinical features of the 2q33.1 microdeletion syndrome. PLoS ONE. 2009;4:e6568 pubmed publisher
    ..The commonly deleted region contains at least seven genes. Haploinsufficiency of one of these genes, SATB2, a DNA-binding protein that regulates gene expression, has been implicated as causative in the cleft or high ..
  5. Chung J, Lau J, Cheng L, Grant R, Robinson F, Ketela T, et al. SATB2 augments ?Np63? in head and neck squamous cell carcinoma. EMBO Rep. 2010;11:777-83 pubmed publisher
    ..In this study, we identify special AT-rich-binding protein 2 (SATB2) as a new ?Np63?-binding protein that is preferentially expressed in advanced-stage primary HNSCC and show that ..
  6. Magnusson K, de Wit M, Brennan D, Johnson L, McGee S, Lundberg E, et al. SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas. Am J Surg Pathol. 2011;35:937-48 pubmed publisher
    The special AT-rich sequence-binding protein 2 (SATB2), a nuclear matrix-associated transcription factor and epigenetic regulator, was identified as a tissue type-specific protein when screening protein expression patterns in human ..
  7. Zhou L, Wu J, Wang W, Yu W, Zhao G, Zhang P, et al. The AT-rich DNA-binding protein SATB2 promotes expression and physical association of human (G)?- and (A)?-globin genes. J Biol Chem. 2012;287:30641-52 pubmed publisher
    ..MARBP SATB2 is recently known as a versatile regulator functioning in the differentiation of multiple cell types including ..
  8. Fitzpatrick D, Carr I, McLaren L, Leek J, Wightman P, Williamson K, et al. Identification of SATB2 as the cleft palate gene on 2q32-q33. Hum Mol Genet. 2003;12:2491-501 pubmed
    ..2q32-q33 that one breakpoint interrupts the transcription unit of the gene encoding the DNA-binding protein SATB2 (formerly KIAA1034)...
  9. Balasubramanian M, Smith K, Basel Vanagaite L, Feingold M, Brock P, Gowans G, et al. Case series: 2q33.1 microdeletion syndrome--further delineation of the phenotype. J Med Genet. 2011;48:290-8 pubmed publisher
    ..Haploinsufficiency of one gene within the deleted region, SATB2, has been suggested to be responsible for most of the features of the syndrome...

More Information

Publications113 found, 100 shown here

  1. Yang M, Yu J, Chen N, Wang X, Liu X, Wang S, et al. Elevated microRNA-31 expression regulates colorectal cancer progression by repressing its target gene SATB2. PLoS ONE. 2013;8:e85353 pubmed publisher
    ..Further studies showed that miR-31 can directly bind to the 3'untranslated region (3'UTR) of SATB2 mRNA and subsequently repress both the mRNA and protein expressions of SATB2...
  2. Agaimy A, Strobel D, Strecker T. SMARCA4-Deficient Carcinoma of Unknown Primary Presenting with Fatal Paraneoplastic Hypercalcemia in a Heart Transplant Recipient: First Report in a Male Patient. Case Rep Pathol. 2017;2017:9403467 pubmed publisher
    ..showed poorly differentiated partially rhabdoid neoplasm expressing pancytokeratin, CK20, and focally GATA3, SATB2, p63, and SALL4. The tumor cells showed dual loss of SMARCA4 and SMARCA2...
  3. Boisvert E, Means R, Michaud M, Madri J, Katz S. Minocycline mitigates the effect of neonatal hypoxic insult on human brain organoids. Cell Death Dis. 2019;10:325 pubmed publisher
    ..expressed over time, while there was a transition in the expression of the deep-layer (TBR1) and upper-layer (SATB2) cortical markers. In addition, ventral genes (Eng1 and Nkx2...
  4. Belus M, Rogers M, Elzubeir A, Josey M, Rose S, Andreeva V, et al. Kir2.1 is important for efficient BMP signaling in mammalian face development. Dev Biol. 2018;444 Suppl 1:S297-S307 pubmed publisher
    ..1 reduces the efficacy of BMP signaling as shown by the reduction of phosphorylated Smad 1/5/8 and reduced expression of BMP targets Smad6 and Satb2.
  5. Moll R. [Transcription factors in tumor diagnosis]. Pathologe. 2018;39:285-290 pubmed publisher
    ..A higher degree of specificity for colorectal origin is provided by SATB2. TTF-1 is a valuable marker particularly for pulmonary adenocarcinomas, but may also be focally expressed "..
  6. Fletcher E, Wade J, Georgala P, Gillespie T, Price D, Pilley E, et al. Oxygen flux reduces Cux1 positive neurons and cortical growth in a gestational rodent model of growth restriction. Ann Anat. 2017;210:84-93 pubmed publisher
    ..Neuronal subtypes were quantified using immunofluorescence for subtype-specific transcription factors (Satb2, Cux1, Ctip2, Tbr1)...
  7. Guo Y, Dong S, Chen X, Jing Y, Yang M, Yan H, et al. Integrating Epigenomic Elements and GWASs Identifies BDNF Gene Affecting Bone Mineral Density and Osteoporotic Fracture Risk. Sci Rep. 2016;6:30558 pubmed publisher
    ..Three genes were significantly associated with spine bone mineral density, including BDNF, PDE4D, and SATB2, which all closely related to bone metabolism...
  8. Miskinyte G, Grønning Hansen M, Monni E, Lam M, Bengzon J, Lindvall O, et al. Transcription factor programming of human ES cells generates functional neurons expressing both upper and deep layer cortical markers. PLoS ONE. 2018;13:e0204688 pubmed publisher
    ..Forebrain Embryonic Zinc Finger-Like Protein 2 (FEZF2), and NGN2 plus Special AT-Rich Sequence-Binding Protein 2 (SATB2), were delivered to human ES cells by lentiviral vectors...
  9. Pfurr S, Chu Y, Bohrer C, Greulich F, Beattie R, Mammadzada K, et al. The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development. Development. 2017;144:3917-3931 pubmed publisher
    ..bHLH) transcription factor E2A splice variant E47 increased the number of Tbr1-positive deep layer and Satb2-positive upper layer neurons at E14...
  10. Phan M, Conte F, Khandelwal K, Ockeloen C, Bartzela T, Kleefstra T, et al. Tooth agenesis and orofacial clefting: genetic brothers in arms?. Hum Genet. 2016;135:1299-1327 pubmed
    ..gene candidates underlying the co-occurrence of the two congenital defects: MSX1, PAX9, IRF6, TP63, KMT2D, KDM6A, SATB2, TBX22, TGFα, TGFβ3, TGFβR1, TGFβR2, FGF8, FGFR1, KISS1R, WNT3, WNT5A, CDH1, CHD7, AXIN2, TWIST1, BCOR,..
  11. Kindberg A, Bendriem R, Spivak C, Chen J, Handreck A, Lupica C, et al. An in vitro model of human neocortical development using pluripotent stem cells: cocaine-induced cytoarchitectural alterations. Dis Model Mech. 2014;7:1397-405 pubmed publisher
    ..along radial glia scaffolding, with deep-layer CTIP2(+) cortical neurons appearing after 1 week and upper-layer SATB2(+) cortical neurons forming during the second and third weeks...
  12. Tantirigama M, Oswald M, Clare A, Wicky H, Day R, Hughes S, et al. Fezf2 expression in layer 5 projection neurons of mature mouse motor cortex. J Comp Neurol. 2016;524:829-45 pubmed publisher
    ..The two Fezf2(+) subtypes expressed either CTIP2 or SATB2 to distinguish their physiological identity and confirmed that specific expression combinations of key ..
  13. Park J, Wada S, Ushida T, Akimoto T. The microRNA-23a has limited roles in bone formation and homeostasis in vivo. Physiol Res. 2015;64:711-9 pubmed
    ..by suppressing the translation of Runx2, a transcription factor essential for osteoblastogenesis, and of Satb2, a member of the special AT-rich binding protein family...
  14. Smith S, Old M, Iwenofu O. Primary Lingual Colonic-Type Adenocarcinoma: A Rare and Emerging Distinct Entity!. Head Neck Pathol. 2017;11:234-239 pubmed publisher
    ..By immunohistochemistry, the tumor cells were positive for AE1/3, CDX2, CK20, SATB2 and beta-catenin...
  15. Múnera J, Sundaram N, Rankin S, Hill D, Watson C, Mahe M, et al. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling. Cell Stem Cell. 2017;21:51-64.e6 pubmed publisher
    ..We found that BMP signaling is required to establish a posterior SATB2+ domain in developing and postnatal intestinal epithelium...
  16. Ji L, Kim N, Huh S, Rhee H. Depletion of Inositol Polyphosphate 4-Phosphatase II Suppresses Callosal Axon Formation in the Developing Mice. Mol Cells. 2016;39:501-7 pubmed publisher
    ..Moreover, depletion of INPP4B significantly attenuated formation of Satb2-positive pyramidal neurons and axon polarization in cortical neurons during cortical development...
  17. Olivares A, Han Y, Soto D, Flattery K, Marini J, Mollema N, et al. The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning. Dev Biol. 2017;429:343-355 pubmed publisher
    ..early cell transcription factors that regulate retinal progenitor cells during development, including amacrine (Satb2) and cone photoreceptor regulators thyroid and retinoic acid receptors...
  18. Li X, Li J, Zhao X, Wang Q, Yang X, Cheng Y, et al. Comparative analysis of molecular activity in dermal mesenchymal stem cells from different passages. Cell Tissue Bank. 2018;19:277-285 pubmed publisher
    ..30- and 6.42-fold, respectively (P < 0.05), whereas SATB2 was downregulated by 39.25-fold (P < 0.05)...
  19. Goolam M, Zernicka Goetz M. The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo. Development. 2017;144:1450-1461 pubmed publisher
    ..This phenotype can be rescued by simultaneous depletion of both Satb1 and Satb2, owing to their antagonistic effect on the pluripotency regulator Nanog...
  20. Feng J, Jing J, Li J, Zhao H, Punj V, Zhang T, et al. BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development. 2017;144:2560-2569 pubmed publisher
    ..Specifically, we identified the transcription factors Pax9, Klf4, Satb2 and Lhx8 as being downstream of BMP signaling and expressed in a spatially restricted pattern that is potentially ..
  21. Addison W, Hall K, Kokabu S, Matsubara T, Fu M, Gori F, et al. Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation. Mol Cell Biol. 2019;39: pubmed publisher
    ..Affinity purification of Zfp423 in myoblasts identified Satb2 as a nuclear partner of Zfp423 that cooperatively enhances Zfp423 transcriptional activity, which in turn affects ..
  22. Cánovas J, Berndt F, Sepúlveda H, Aguilar R, Veloso F, Montecino M, et al. The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a. J Neurosci. 2015;35:7552-64 pubmed publisher
    ..factor CTIP1; CTIP1 is coexpressed with CTIP2 in neurons that project to subcerebral targets and with SATB2 in those that project to the contralateral cortex...
  23. Righi A, Gambarotti M, Manfrini M, Benini S, Gamberi G, Cocchi S, et al. Sclerosing epithelioid fibrosarcoma of the thigh: report of two cases with synchronous bone metastases. Virchows Arch. 2015;467:339-44 pubmed publisher
    ..the distinct pattern of immunohistochemical staining for MUC4, associated with the absence of staining for both SATB2, a marker of osteoblastic differentiation, and pan-cytokeratin, allows differentiating between sclerosing ..
  24. Kikuchi K, Fukunaga S, Ide F, Hoshino M, Inoue H, Miyazaki Y, et al. Primary intestinal-type adenocarcinoma of the buccal mucosa: A case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;127:e61-e70 pubmed publisher
    ..Immunohistochemically, the tumor cells were diffusely positive for AE1/AE3, CAM5.2, CK7, SATB2, β-catenin, p53, Ki-67, MUC2, and MUC5 AC. CK14 and CK20 were positive in some of the tumor cells...
  25. Begum A, Aguilar J, Hong Y. Aqueous cigarette tar extracts disrupt corticogenesis from human embryonic stem cells in vitro. Environ Res. 2017;158:194-202 pubmed publisher
    ..neuronal progenitor markers pax6, tbr2, and neuroD and decreased the number of cortical layer neurons (tbr1, satb2, foxp2, and brn2) after exposure to as low as 1.87% of the extract from one smoked cigarette butt...
  26. Mohamad Shah N, Salahshourifar I, Sulong S, Wan Sulaiman W, Halim A. Discovery of candidate genes for nonsyndromic cleft lip palate through genome-wide linkage analysis of large extended families in the Malay population. BMC Genet. 2016;17:39 pubmed publisher
    ..Several candidate genes in linkage intervals were determined; LPHN2 at 1p31, SATB2 at 2q33.1-q35, PVRL3 at 3q13.3, COL21A1 at 6p12.1, FOXP2 at 7q22...
  27. Conte F, Oti M, Dixon J, Carels C, Rubini M, Zhou H. Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts. Hum Genet. 2016;135:41-59 pubmed publisher
    ..Our analyses of these overlapping CNVs identified two genes known to be causative for human OFCs, SATB2 and MEIS2, and 12 genes (DGCR6, FGF2, FRZB, LETM1, MAPK3, SPRY1, THBS1, TSHZ1, TTC28, TULP4, WHSC1, WHSC2) that ..
  28. Bifari F, Decimo I, Pino A, Llorens Bobadilla E, Zhao S, Lange C, et al. Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex. Cell Stem Cell. 2017;20:360-373.e7 pubmed publisher
    ..progenitors formed during embryonic development that migrate to the caudal cortex and differentiate into Satb2+ neurons in cortical layers II-IV...
  29. Yan M, Wang Y, Yang M, Liu Y, Qu B, Ye Z, et al. The effects and mechanisms of clinorotation on proliferation and differentiation in bone marrow mesenchymal stem cells. Biochem Biophys Res Commun. 2015;460:327-32 pubmed publisher
    ..While alterations of the osteoblast differentiation due to the decreased SATB2 expression induced by simulated microgravity in BMSCs.
  30. Nomura T, Yamashita W, Gotoh H, Ono K. Species-Specific Mechanisms of Neuron Subtype Specification Reveal Evolutionary Plasticity of Amniote Brain Development. Cell Rep. 2018;22:3142-3151 pubmed publisher
    ..In the mammalian neocortex, the transcription factors (TFs) Ctip2 and Satb2 are differentially expressed in layer-specific neurons...
  31. Weaver C, Miller S, da Fontoura C, Wehby G, Amendt B, Holton N, et al. Candidate gene analyses of 3-dimensional dentoalveolar phenotypes in subjects with malocclusion. Am J Orthod Dentofacial Orthop. 2017;151:539-558 pubmed publisher
    ..1. Fluctuating asymmetry was associated with BMP3 and LATS1. Associations for SATB2 and BMP3 with asymmetric variations remained significant after the Bonferroni correction (P <0.00022)...
  32. Fish J. Developmental mechanisms underlying variation in craniofacial disease and evolution. Dev Biol. 2016;415:188-197 pubmed publisher
    ..outlining developmental mechanisms underlying mutational increases in phenotypic variance are discussed using Satb2-mediated variation in jaw size as an example...
  33. Cao S, Hu Y, Chen C, Yuan F, Xu M, Li Q, et al. Enhanced derivation of human pluripotent stem cell-derived cortical glutamatergic neurons by a small molecule. Sci Rep. 2017;7:3282 pubmed publisher
    ..manner and enhanced the generation of cortical glutamatergic neurons, expressing PAX6, TBR1, TBR2, CTIP2, SATB2, and vesicular glutamate transporters (vGLUT)...
  34. Gil Sanz C, Espinosa A, Fregoso S, Bluske K, Cunningham C, Martinez Garay I, et al. Lineage Tracing Using Cux2-Cre and Cux2-CreERT2 Mice. Neuron. 2015;86:1091-1099 pubmed publisher
    ..mice that recapitulate the endogenous Cux2 expression pattern, the vast majority of fate-mapped neurons express Satb2 but not Ctip2, confirming that a restricted subset of all neocortical projection neurons belongs to the Cux2 ..
  35. Li Z, Roth R, Rock J, Lehman A, Marsh W, Suarez A, et al. Dual Immunostain With SATB2 and CK20 Differentiates Appendiceal Mucinous Neoplasms From Ovarian Mucinous Neoplasms. Am J Clin Pathol. 2017;147:484-491 pubmed publisher
    ..Special AT-rich sequence binding protein 2 (SATB2) has been shown to be highly selectively expressed in the lower gastrointestinal tract, including the appendix.
  36. Bian T, Zhao J, Feng J, Zhang Q, Qian L, Liu J, et al. Combination of cadherin-17 and SATB homeobox 2 serves as potential optimal makers for the differential diagnosis of pulmonary enteric adenocarcinoma and metastatic colorectal adenocarcinoma. Oncotarget. 2017;8:63442-63452 pubmed publisher
    ..Cadherin-17 (CDH17) and SATB homeobox 2 (SATB2) immunoexpression have recently been demonstrated in colorectal adenocarcinoma...
  37. Li G, Martínez Bonet M, Wu D, Yang Y, Cui J, Nguyen H, et al. High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction. Nat Genet. 2018;50:1180-1188 pubmed publisher
    ..arthritis, we identified 148 candidate fSNPs, including two that regulate STAT4 via the regulatory proteins SATB2 and H1.2...
  38. Wang P, Zhao D, Lachman H, Zheng D. Enriched expression of genes associated with autism spectrum disorders in human inhibitory neurons. Transl Psychiatry. 2018;8:13 pubmed publisher
    ..Furthermore, the downstream targets of several ASD candidates, such as CHD8, EHMT1 and SATB2, also displayed enriched expression in inhibitory neurons...
  39. Ainsworth R, Ai R, Ding B, Li N, Zhang K, Wang W. Bayesian Networks Predict Neuronal Transdifferentiation. G3 (Bethesda). 2018;8:2501-2511 pubmed publisher
    ..of gene knockout and overexpression, we discover novel neuronal trans-differrentiation recipes (including perturbations of SATB2, GAD1, POU6F2 and ADARB2) for excitatory projection neuron and inhibitory interneuron subtypes.
  40. Byrne E, Gehrman P, Medland S, Nyholt D, Heath A, Madden P, et al. A genome-wide association study of sleep habits and insomnia. Am J Med Genet B Neuropsychiatr Genet. 2013;162B:439-51 pubmed publisher
    ..We did not replicate the results from previous genome-wide analyses of self-reported sleep phenotypes after correction for multiple testing. ..
  41. Gong Y, Lu J, Yu X, Yu Y. Expression of Sp7 in Satb2-induced osteogenic differentiation of mouse bone marrow stromal cells is regulated by microRNA-27a. Mol Cell Biochem. 2016;417:7-16 pubmed publisher
    b>Satb2 is a special AT-rich binding transcription factor essential for osteoblast differentiation and bone formation. Specific microRNAs (miRNAs) have been identified to regulate the complex process of osteogenic differentiation...
  42. Li Y, Liu Y, Hu Y, Chen L, Li J. Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells. World J Gastroenterol. 2016;22:8528-8539 pubmed
    To find the mechanisms by which special AT-rich sequence-binding protein 2 (SATB2) influences colorectal cancer (CRC) metastasis...
  43. Sweeney N, James K, Nistorica A, Lorig Roach R, Feldheim D. Expression of transcription factors divides retinal ganglion cells into distinct classes. J Comp Neurol. 2019;527:225-235 pubmed publisher
    ..that end, we show here that nearly all RGCs express either Islet-2 (Isl2), Tbr2, or a combination of Satb1 and Satb2. We present gene expression data supporting the hypothesis that Satb1 and Satb2 are expressed in ON-OFF direction-..
  44. Perez Montiel D, Arispe Angulo K, Cantú De León D, Bornstein Quevedo L, Chanona Vilchis J, Herrera Montalvo L. The value of SATB2 in the differential diagnosis of intestinal-type mucinous tumors of the ovary: primary vs metastatic. Ann Diagn Pathol. 2015;19:249-52 pubmed publisher
    ..b>SATB2 is a recently identified protein with restricted expression in the glandular cells lining the lower ..
  45. Beaty T, Hetmanski J, Fallin M, Park J, Sull J, McIntosh I, et al. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. Hum Genet. 2006;120:501-18 pubmed
    ..were genotyped for 962 SNPs in 104 genes on chromosome 2, including two well-recognized candidate genes: TGFA and SATB2. Individual SNPs and haplotypes (in sliding windows of 2-5 SNPs) were used to test for linkage and disequilibrium ..
  46. Liu T, Xu L, Yang A, Zhong Q, Song M, Li M, et al. Decreased expression of SATB2: a novel independent prognostic marker of worse outcome in laryngeal carcinoma patients. PLoS ONE. 2012;7:e40704 pubmed publisher
    To investigate the expression and role of special AT-rich sequence-binding protein-2 (SATB2) in laryngeal squamous cell carcinoma (LSCC) tissue and cell line (HEp2), and to evaluate the clinical and prognostic significance of SATB2 ..
  47. Strickland S, Parra Herran C. Immunohistochemical characterization of appendiceal mucinous neoplasms and the value of special AT-rich sequence-binding protein 2 in their distinction from primary ovarian mucinous tumours. Histopathology. 2016;68:977-87 pubmed publisher
    ..Special AT-rich sequence-binding protein 2 (SATB2) has recently been described as a sensitive and specific marker of colorectal epithelium...
  48. Shinmyo Y, Kawasaki H. CRISPR/Cas9-Mediated Gene Knockout in the Mouse Brain Using In Utero Electroporation. Curr Protoc Neurosci. 2017;79:3.32.1-3.32.11 pubmed publisher
    ..The pX330 plasmids are delivered into the rodent brain using in utero electroporation. Focusing on the Satb2 gene, which encodes an AT-rich DNA-binding transcription factor, we found that the introduction of pX330-Satb2 ..
  49. Berg K, Schaeffer D. SATB2 as an Immunohistochemical Marker for Colorectal Adenocarcinoma: A Concise Review of Benefits and Pitfalls. Arch Pathol Lab Med. 2017;141:1428-1433 pubmed publisher
    b>SATB2 is part of the family of matrix attachment region-binding transcription factors, and has developmental roles in craniofacial, neural, and osteoblastic differentiation...
  50. Lin F, Shi J, Zhu S, Chen Z, Li A, Chen T, et al. Cadherin-17 and SATB2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine. Arch Pathol Lab Med. 2014;138:1015-26 pubmed publisher
    ..of cadherin-17 and SATB-2 and other markers in medullary carcinomas of the large intestine and cadherin-17 and SATB2 in a large number of carcinomas and normal tissues from various organs to further test their diagnostic ..
  51. Gharahkhani P, Fitzgerald R, Vaughan T, Palles C, Gockel I, Tomlinson I, et al. Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis. Lancet Oncol. 2016;17:1363-1373 pubmed publisher
    ..p=3·2 × 10-9), TMOD1 (rs7852462; p=1·5 × 10-8), SATB2 (rs139606545; p=2·0 × 10-8), and HTR3C and ABCC5 (rs9823696; p=1·6 ×â..
  52. Hantman A, Kaltschmidt J. Satb2 Stations Neurons along Reflex Arcs. Neuron. 2016;91:711-713 pubmed publisher
    ..They assess how a DNA-binding factor Satb2 controls cell position, molecular identity, pre-and postsynaptic targeting, and function of a population of ..
  53. Sangoi A, Kshirsagar M, Roma A, Horvai A, Chivukula M, Ellenson L, et al. Interobserver Reproducibility Among Gynecologic Pathologists in Diagnosing Heterologous Osteosarcomatous Component in Gynecologic Tract Carcinosarcomas. Int J Gynecol Pathol. 2017;36:386-392 pubmed publisher
    ..in the diagnosis of osteosarcomatous components, and its correlation with expression of the novel antibody SATB2 (marker of osteoblastic differentiation) in these osteosarcomatous foci...
  54. Lee J, Yoo Y, Lim B, Kim K, Choi M, Chae J. SATB2-associated syndrome presenting with Rett-like phenotypes. Clin Genet. 2016;89:728-32 pubmed publisher
    The SATB2-associated syndrome (SAS) was proposed recently, after the SATB2 gene was initially discovered to be associated with isolated cleft palate...
  55. Schwartz E, Wilkens A, Noon S, Krantz I, Wu Y. A de novo SATB2 mutation in monozygotic twins with cleft palate, dental anomalies, and developmental delay. Am J Med Genet A. 2017;173:809-812 pubmed publisher
  56. Ma Y, Zhang H, Fei L, Zhang M, Wang C, Luo Y, et al. SATB2 suppresses non-small cell lung cancer invasiveness by G9a. Clin Exp Med. 2018;18:37-44 pubmed publisher
    Special AT-rich sequence-binding protein 2 (SATB2) is a transcription factor, which plays an important role in transcriptional regulation and chromatin recombinant by combining with matrix attachment regions...
  57. Maussion G, Diallo A, Gigek C, Chen E, Crapper L, Théroux J, et al. Investigation of genes important in neurodevelopment disorders in adult human brain. Hum Genet. 2015;134:1037-53 pubmed publisher
    ..cell(NSC) lines at different developmental stages and adult human brain, targeting two genes associated with NDDs, SATB2 and EHMT1, and the WNT signaling gene TCF7L2, which has not been associated with NDDs...
  58. Liu S, Zhu J, Xu H, Zhang G, Wang Y, Liu Y, et al. A novel antisense long non-coding RNA SATB2-AS1 overexpresses in osteosarcoma and increases cell proliferation and growth. Mol Cell Biochem. 2017;430:47-56 pubmed publisher
    ..The antisense transcript of SATB2 protein (SATB2-AS1) was identified as one of the upregulated lncRNAs...
  59. Yang M, Yu J, Jiang D, Li W, Wang S, Ding Y. microRNA-182 targets special AT-rich sequence-binding protein 2 to promote colorectal cancer proliferation and metastasis. J Transl Med. 2014;12:109 pubmed publisher
    ..Further research showed that miR-182 could directly target the 3'untranslated region (3'UTR) of SATB2 mRNA and subsequently repress both the mRNA and protein expressions of SATB2, which we identified in previous ..
  60. Ge J, Guo S, Fu Y, Zhou P, Zhang P, Du Y, et al. Dental Follicle Cells Participate in Tooth Eruption via the RUNX2-MiR-31-SATB2 Loop. J Dent Res. 2015;94:936-44 pubmed publisher
    ..evidence has revealed a key regulatory circuit, including RUNX2, miR-31, and special AT-rich binding protein 2 (SATB2) acting in concert in mesenchymal stem cell homeostasis and functions...
  61. Yu W, Ma Y, Shankar S, Srivastava R. SATB2/β-catenin/TCF-LEF pathway induces cellular transformation by generating cancer stem cells in colorectal cancer. Sci Rep. 2017;7:10939 pubmed publisher
    ..The main goal of this paper was to examine the molecular mechanisms by which SATB2 induced malignant transformation of colorectal epithelial cells...
  62. McGovern D, Gardet A, Törkvist L, Goyette P, Essers J, Taylor K, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet. 2010;42:332-7 pubmed publisher
    ..These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis. ..
  63. Conner J, Hornick J. SATB2 is a novel marker of osteoblastic differentiation in bone and soft tissue tumours. Histopathology. 2013;63:36-49 pubmed publisher
    ..b>SATB2 is a nuclear protein that plays a critical role in osteoblast lineage commitment...
  64. Liu C, Monda K, Taylor K, Lange L, Demerath E, Palmas W, et al. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013;9:e1003681 pubmed publisher
    ..These findings reinforce the concept that there are fat distribution loci that are independent of generalized adiposity. ..
  65. Zhang Y, Li S, Yi Yang K, Liu M, Lee N, Tang X, et al. Whole genome methylation array reveals the down-regulation of IGFBP6 and SATB2 by HIV-1. Sci Rep. 2015;5:10806 pubmed publisher
    ..We found that IGFBP6 and SATB2 were significantly down-regulated in HIV-infected CEM*174 cells and 3 different cohorts of HIV/AIDS patients while ..
  66. Li Z, Yuan J, Wei L, Zhou L, Mei K, Yue J, et al. SATB2 is a sensitive marker for lower gastrointestinal well-differentiated neuroendocrine tumors. Int J Clin Exp Pathol. 2015;8:7072-82 pubmed
    Special AT-rich sequence binding protein-2 (SATB2) is selectively expressed in the lower gastrointestinal tract mucosa and has been identified as a sensitive marker for colorectal adenocarcinomas...
  67. Fukuhara M, Agnarsdottir M, Edqvist P, Coter A, Ponten F. SATB2 is expressed in Merkel cell carcinoma. Arch Dermatol Res. 2016;308:449-54 pubmed publisher
    ..The expression of the special AT-rich sequence-binding protein (SATB2) was analyzed in MCC (n = 20) together with other forms of skin cancer and neuroendocrine tumors (n = 51) ..
  68. Sangoi A, Kshirsagar M, Horvai A, Roma A. SATB2 Expression Is Sensitive but Not Specific for Osteosarcomatous Components of Gynecologic Tract Carcinosarcomas: A Clinicopathologic Study of 60 Cases. Int J Gynecol Pathol. 2017;36:140-145 pubmed publisher
    The novel marker special AT-rich sequence binding protein (SATB2) is highly sensitive for mesenchymal tumors with osteoblastic differentiation...
  69. Yu W, Ma Y, Ochoa A, Shankar S, Srivastava R. Cellular transformation of human mammary epithelial cells by SATB2. Stem Cell Res. 2017;19:139-147 pubmed publisher
    ..b>SATB2 (special AT-rich binding protein-2) is a newly identified transcription factor and epigenetic regulator...
  70. Seong B, Lau J, Adderley T, Kee L, Chaukos D, Pienkowska M, et al. SATB2 enhances migration and invasion in osteosarcoma by regulating genes involved in cytoskeletal organization. Oncogene. 2015;34:3582-92 pubmed publisher
    ..In this study, we report that special AT-rich-binding protein 2 (SATB2) is highly expressed in OS cells and tumors...
  71. Guo C, Xiong D, Yao X, Gu W, Zhang H, Yang B, et al. Decreased SATB2 expression is associated with metastasis and poor prognosis in human clear cell renal cell carcinoma. Int J Clin Exp Pathol. 2015;8:3710-8 pubmed
    In this study, we investigate the expression and role of special AT-rich sequence-binding protein-2 (SATB2) in clear cell renal cell carcinoma (ccRCC) tissue, and to evaluate the clinical and prognostic significance of SATB2 protein in ..
  72. Ambrozkiewicz M, Bessa P, Salazar Lázaro A, Salina V, Tarabykin V. Satb2Cre/+ mouse as a tool to investigate cell fate determination in the developing neocortex. J Neurosci Methods. 2017;291:113-121 pubmed publisher
    ..The transcription factor Satb2 is expressed in neocortical projection neurons that send their axons intracortically as opposed to Satb2-negative ..
  73. Argani P, Kao Y, Zhang L, Bacchi C, Matoso A, Alaggio R, et al. Primary Renal Sarcomas With BCOR-CCNB3 Gene Fusion: A Report of 2 Cases Showing Histologic Overlap With Clear Cell Sarcoma of Kidney, Suggesting Further Link Between BCOR-related Sarcomas of the Kidney and Soft Tissues. Am J Surg Pathol. 2017;41:1702-1712 pubmed publisher
    ..Both neoplasms demonstrated immunoreactivity for BCOR, cyclin D1, TLE1, and SATB2 in the spindle neoplastic cells and negativity in the prominent capillary vasculature...
  74. Wu G, Xu R, Zhang P, Xiao T, Fu Y, Zhang Y, et al. Estrogen regulates stemness and senescence of bone marrow stromal cells to prevent osteoporosis via ERβ-SATB2 pathway. J Cell Physiol. 2018;233:4194-4204 pubmed publisher
    ..Special AT-rich sequence binding protein 2 (SATB2) is crucial for maintaining stemness and osteogenic differentiation of BMSCs...
  75. Wei J, Lin Y, Tsai C, Shieh H, Lin P, Ho W, et al. SATB2 participates in regulation of menadione-induced apoptotic insults to osteoblasts. J Orthop Res. 2012;30:1058-66 pubmed publisher
    Special AT-rich sequence binding protein 2 (SATB2), a nuclear matrix attachment region-binding protein, can regulate embryonic development, cell differentiation, and cell survival...
  76. Kaiser A, Maas B, Wolff A, Sutter C, Janssen J, Hinderhofer K, et al. Characterization of the first intragenic SATB2 duplication in a girl with intellectual disability, nearly absent speech and suspected hypodontia. Eur J Hum Genet. 2015;23:704-7 pubmed publisher
    b>SATB2, a gene encoding a highly conserved DNA-binding protein, is known to have an important role in craniofacial and neuronal development. Only a few patients with SATB2 variants have been described so far...
  77. Boone P, Chan Y, Hunter J, Pottkotter L, Davino N, Yang Y, et al. Increased bone turnover, osteoporosis, progressive tibial bowing, fractures, and scoliosis in a patient with a final-exon SATB2 frameshift mutation. Am J Med Genet A. 2016;170:3028-3032 pubmed publisher
    Haploinsufficiency of SATB2 causes cleft palate, intellectual disability with deficient speech, facial and dental abnormalities, and other variable features known collectively as SATB2-associated syndrome...
  78. Zhou P, Wu G, Zhang P, Xu R, Ge J, Fu Y, et al. SATB2-Nanog axis links age-related intrinsic changes of mesenchymal stem cells from craniofacial bone. Aging (Albany NY). 2016;8:2006-2011 pubmed publisher
    ..Here, we found that the expression of special AT-rich binding protein 2 (SATB2) in human AB-BMSCs significantly decreased with aging...
  79. Luo L, Yang F, Ding J, Yan D, Wang D, Yang S, et al. MiR-31 inhibits migration and invasion by targeting SATB2 in triple negative breast cancer. Gene. 2016;594:47-58 pubmed publisher
    ..The special AT-rich sequence-binding protein-2 (SATB2) has been reported to involve in tumor proliferation and invasion, but its function and relationship with miR-31 ..
  80. Xu R, Fu Z, Liu X, Xiao T, Zhang P, Du Y, et al. Transplantation of osteoporotic bone marrow stromal cells rejuvenated by the overexpression of SATB2 prevents alveolar bone loss in ovariectomized rats. Exp Gerontol. 2016;84:71-79 pubmed publisher
    ..In this study, we aimed to investigate the role of the special AT-rich sequence-binding protein 2 (SATB2), a stemness and senescence regulator of craniofacial BMSCs, in rat ovariectomy-induced alveolar osteoporosis...
  81. Kriegsmann M, Harms A, Longuespée R, Muley T, Winter H, Kriegsmann K, et al. Role of Conventional Immunomarkers, HNF4-a, and SATB2 in the Differential Diagnosis of Pulmonary and Colorectal Adenocarcinomas. Histopathology. 2017;: pubmed publisher
    ..Hepatocyte nuclear factor 4 alpha (HNF4-a) and special AT-rich sequence-binding protein 2 (SATB2) were recently described as promising additional markers, but comprehensive large scale data are lacking so far...
  82. Wu L, Chen J, Qin Y, Mo X, Huang M, Ru H, et al. SATB2 suppresses gastric cancer cell proliferation and migration. Tumour Biol. 2016;37:4597-602 pubmed publisher
    ..Special AT-rich sequence-binding protein 2 (SATB2) is a new tumor suppressive gene and plays important roles in many cancers...
  83. Mi W, Shi Q, Chen X, Wu T, Huang H. miR-33a-5p modulates TNF-α-inhibited osteogenic differentiation by targeting SATB2 expression in hBMSCs. FEBS Lett. 2016;590:396-407 pubmed publisher
    ..Luciferase reporter assays and western blotting demonstrated that special AT-rich sequence-binding protein 2 (SATB2) is a target of miR-33a-5p...
  84. Matsushima J, Yazawa T, Suzuki M, Takahashi Y, Ota S, Nakajima T, et al. Clinicopathological, immunohistochemical, and mutational analyses of pulmonary enteric adenocarcinoma: usefulness of SATB2 and β-catenin immunostaining for differentiation from metastatic colorectal carcinoma. Hum Pathol. 2017;64:179-185 pubmed publisher
    ..follows: CK7, 88% (7/8); CK20, 88% (7/8); TTF-1, 13% (1/8); β-catenin, 0% (0/8, strong nuclear expression); and SATB2, 13% (1/8). The positive rates of MCRC for these antibodies were 10%, 95%, 5%, 55%, and 100%, respectively...
  85. Chung J, Grant R, Kaplan D, Irwin M. Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins. J Biol Chem. 2011;286:40671-80 pubmed publisher
    ..that AEC p63 mutations affect the ability of the p63 protein to interact with special AT-rich binding protein-2 (SATB2), which has recently also been implicated in the development of cleft palate...
  86. Mansour M, Hyodo T, Ito S, Kurita K, Kokuryo T, Uehara K, et al. SATB2 suppresses the progression of colorectal cancer cells via inactivation of MEK5/ERK5 signaling. FEBS J. 2015;282:1394-405 pubmed publisher
    Special AT-rich sequence binding protein 2 (SATB2) is an evolutionarily conserved transcription factor that has multiple roles in neuronal development, osteoblast differentiation, and craniofacial patterning...
  87. Giannico G, Gown A, Epstein J, Revetta F, Bishop J. Role of SATB2 in distinguishing the site of origin in glandular lesions of the bladder/urinary tract. Hum Pathol. 2017;67:152-159 pubmed publisher
    ..Special AT-rich sequence-binding protein 2 (SATB2), encoded on chromosome 2q32-33, is a recently described DNA-binding protein involved in osteoblast lineage ..
  88. Elebro J, Heby M, Gaber A, Nodin B, Jonsson L, Fristedt R, et al. Prognostic and treatment predictive significance of SATB1 and SATB2 expression in pancreatic and periampullary adenocarcinoma. J Transl Med. 2014;12:289 pubmed publisher
    ..1 (SATB1) has been demonstrated to confer a worse prognosis in several tumour types, whereas its close homologue SATB2 is a proposed diagnostic and favourable prognostic marker for colorectal cancer...
  89. Brocato J, Costa M. SATB1 and 2 in colorectal cancer. Carcinogenesis. 2015;36:186-91 pubmed publisher
    ..Expression of the SATB2 gene is tissue-specific, and the only epithelial cells expressing SATB2 are the glandular cells of the lower ..
  90. Jiang G, Cui Y, Yu X, Wu Z, Ding G, Cao L. miR-211 suppresses hepatocellular carcinoma by downregulating SATB2. Oncotarget. 2015;6:9457-66 pubmed
    ..Luciferase reporter assays and western blot indicated that special AT-rich sequence-binding protein-2 (SATB2), is a direct target of miR-211...
  91. Moh M, Krings G, Ates D, Aysal A, Kim G, Rabban J. SATB2 Expression Distinguishes Ovarian Metastases of Colorectal and Appendiceal Origin From Primary Ovarian Tumors of Mucinous or Endometrioid Type. Am J Surg Pathol. 2016;40:419-32 pubmed publisher
    ..Recently, immunohistochemical expression of SATB2, a transcriptional regulator involved in osteoblastic and neuronal differentiation, has been shown to be a highly ..