SATB1

Summary

Gene Symbol: SATB1
Description: SATB homeobox 1
Alias: DNA-binding protein SATB1, special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)
Species: human
Products:     SATB1

Top Publications

  1. Seo J, Lozano M, Dudley J. Nuclear matrix binding regulates SATB1-mediated transcriptional repression. J Biol Chem. 2005;280:24600-9 pubmed
    Special AT-rich binding protein 1 (SATB1) originally was identified as a protein that bound to the nuclear matrix attachment regions (MARs) of the immunoglobulin heavy chain intronic enhancer...
  2. Tan J, Sun Y, Song J, Chen Y, Krontiris T, Durrin L. SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage. J Biol Chem. 2008;283:18124-34 pubmed publisher
    b>SATB1 (special AT-rich sequence-binding protein-1) provides a key link between DNA loop organization, chromatin modification/remodeling, and association of transcription factors at matrix attachment regions (MARs)...
  3. Kumar P, Mehta S, Purbey P, Notani D, Jayani R, Purohit H, et al. SATB1-binding sequences and Alu-like motifs define a unique chromatin context in the vicinity of human immunodeficiency virus type 1 integration sites. J Virol. 2007;81:5617-27 pubmed
    ..Additionally, these sequences were preferentially bound by SATB1, the T lineage-restricted chromatin organizer, in vitro and in vivo...
  4. ORDINARIO E, Han H, Furuta S, Heiser L, Jakkula L, Rodier F, et al. ATM suppresses SATB1-induced malignant progression in breast epithelial cells. PLoS ONE. 2012;7:e51786 pubmed publisher
    b>SATB1 drives metastasis when expressed in breast tumor cells by radically reprogramming gene expression. Here, we show that SATB1 also has an oncogenic activity to transform certain non-malignant breast epithelial cell lines...
  5. Meng W, Yan H, Zhou B, Zhang W, Kong X, Wang R, et al. Correlation of SATB1 overexpression with the progression of human rectal cancer. Int J Colorectal Dis. 2012;27:143-50 pubmed publisher
    To date, the association between special AT-rich sequence-binding protein 1 (SATB1) and colorectal cancer (CRC) has not been reported...
  6. Hanker L, Karn T, Mavrova Risteska L, Ruckhäberle E, Gaetje R, Holtrich U, et al. SATB1 gene expression and breast cancer prognosis. Breast. 2011;20:309-13 pubmed publisher
    Recently it has been shown that the genome organizer SATB1 plays an important role in breast cancer progression and predicts a poor prognosis. However its prognostic value compared to markers as the estrogen receptor is currently unclear...
  7. Liu C, Wen Y, Xu K, Zheng S, Xu Y, Chen B. [Expression of special AT-rich sequence-binding protein in bladder urothelial carcinoma and its clinical significance]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:1389-91, 1394 pubmed
    To detect the expression of special AT-rich sequence-binding protein (SATB1) in bladder urothelial carcinoma and investigate its correlation to the biological behavior of the carcinoma...
  8. Zhou L, Liu F, Tong J, Chen Q, Zhang F. [Expression of special AT-rich sequence-binding protein mRNA and its clinicopathological significance in non-small cell lung cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:534-7 pubmed
    To detect the expression of AT-rich sequence-binding protein (SATB1) mRNA in non-small cell lung cancer (NSCLC) and explore the role of SATB1 in the development of NSCLC...
  9. Zhang J, Zhang B, Zhang X, Sun Y, Wei X, McNutt M, et al. SATB1 expression is associated with biologic behavior in colorectal carcinoma in vitro and in vivo. PLoS ONE. 2013;8:e47902 pubmed publisher
    There is increasing evidence that Special AT-rich sequence-binding protein 1 (SATB1) is aberrantly expressed in several cancers and is correlated with clinicopathologic parameters in these tumors...

More Information

Publications71

  1. Notani D, Gottimukkala K, Jayani R, Limaye A, Damle M, Mehta S, et al. Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner. PLoS Biol. 2010;8:e1000296 pubmed publisher
    ..Here we show that special AT-rich binding protein 1 (SATB1), the T lineage-enriched chromatin organizer and global regulator, interacts with beta-catenin and recruits it to ..
  2. Yamaguchi H, Tateno M, Yamasaki K. Solution structure and DNA-binding mode of the matrix attachment region-binding domain of the transcription factor SATB1 that regulates the T-cell maturation. J Biol Chem. 2006;281:5319-27 pubmed
    b>SATB1 is a transcriptional regulator controlling the gene expression that is essential in the maturation of the immune T-cell...
  3. Wen J, Huang S, Rogers H, Dickinson L, Kohwi Shigematsu T, Noguchi C. SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression. Blood. 2005;105:3330-9 pubmed
    Special AT-rich binding protein 1 (SATB1) nuclear protein, expressed predominantly in T cells, regulates genes through targeting chromatin remodeling during T-cell maturation...
  4. Beyer M, Thabet Y, Muller R, Sadlon T, Classen S, Lahl K, et al. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol. 2011;12:898-907 pubmed publisher
    ..Here we report that repression of SATB1, a genome organizer that regulates chromatin structure and gene expression, was crucial for the phenotype and ..
  5. Galande S, Dickinson L, Mian I, Sikorska M, Kohwi Shigematsu T. SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis. Mol Cell Biol. 2001;21:5591-604 pubmed
    b>SATB1 is expressed primarily in thymocytes and orchestrates temporal and spatial expression of a large number of genes in the T-cell lineage...
  6. Xia J, Qin X, Han S, Wu A. Phosphorylated SATB1 is associated with the progression and prognosis of glioma. Cell Death Dis. 2013;4:e901 pubmed publisher
    Special AT-rich sequence-binding protein 1 (SATB1) is a global chromatin organizer and gene regulator, and high expression of SATB1 is associated with progression and poor prognosis in several malignancies...
  7. Dickinson L, Joh T, Kohwi Y, Kohwi Shigematsu T. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. Cell. 1992;70:631-45 pubmed
    A human cDNA was cloned that encodes a DNA-binding protein (SATB1) that is expressed predominantly in thymus and binds selectively to the nuclear matrix/scaffold-associating DNAs (MARs/SARs)...
  8. Kohwi Shigematsu T, Poterlowicz K, ORDINARIO E, Han H, Botchkarev V, KOHWI Y. Genome organizing function of SATB1 in tumor progression. Semin Cancer Biol. 2013;23:72-9 pubmed publisher
    ..Transcription factors must also be accurately assembled at these loci. SATB1 is a genome organizer protein that facilitates these processes, providing a nuclear architectural platform that ..
  9. Nodin B, Johannesson H, Wangefjord S, O Connor D, Lindquist K, Uhlen M, et al. Molecular correlates and prognostic significance of SATB1 expression in colorectal cancer. Diagn Pathol. 2012;7:115 pubmed publisher
    Special AT-rich sequence-binding protein 1 (SATB1) is a global gene regulator that has been reported to confer malignant behavior and associate with poor prognosis in several cancer forms...
  10. Gong H, Wang Z, Zhao G, Lv X, Wei G, Wang L, et al. SATB1 regulates beta-like globin genes through matrix related nuclear relocation of the cluster. Biochem Biophys Res Commun. 2009;383:11-5 pubmed publisher
    The nuclear location and relocation of genes play crucial regulatory roles in gene expression. SATB1, a MAR-binding protein, has been found to regulate beta-like globin genes through chromatin remodeling...
  11. Liu J, Barnett A, Neufeld E, Dudley J. Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation. Mol Cell Biol. 1999;19:4918-26 pubmed
    ..The homeoproteins CCAAT displacement protein (CDP) and special AT-rich sequence binding protein 1 (SATB1) have been shown to bind to nuclear matrix-associated regions and to act as repressors of many cellular genes...
  12. Purbey P, Singh S, Notani D, Kumar P, Limaye A, Galande S. Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1. Mol Cell Biol. 2009;29:1321-37 pubmed publisher
    Special AT-rich binding protein 1 (SATB1) acts as a global regulator of gene expression by recruiting various corepressor or coactivator complexes, thereby establishing a unique chromatin structure at its genomic targets in a context-..
  13. Han H, Russo J, KOHWI Y, Kohwi Shigematsu T. SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature. 2008;452:187-93 pubmed publisher
    Mechanisms underlying global changes in gene expression during tumour progression are poorly understood. SATB1 is a genome organizer that tethers multiple genomic loci and recruits chromatin-remodelling enzymes to regulate chromatin ..
  14. Notani D, Ramanujam P, Kumar P, Gottimukkala K, Kumar Sinha C, Galande S. N-terminal PDZ-like domain of chromatin organizer SATB1 contributes towards its function as transcription regulator. J Biosci. 2011;36:461-9 pubmed
    The special AT-rich DNA-binding protein 1 (SATB1) is a matrix attachment region (MAR)-binding protein that acts as a global repressor via recruitment of CtBP1:HDAC1-containing co-repressors to its binding targets...
  15. Pavan Kumar P, Purbey P, Sinha C, Notani D, Limaye A, Jayani R, et al. Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. Mol Cell. 2006;22:231-43 pubmed
    b>SATB1 regulates gene expression by acting as a "docking site" for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters...
  16. Cai S, Han H, Kohwi Shigematsu T. Tissue-specific nuclear architecture and gene expression regulated by SATB1. Nat Genet. 2003;34:42-51 pubmed
    ..Little is known about how higher-order chromatin packaging might affect gene expression. SATB1 is a cell-type specific nuclear protein that recruits chromatin-remodeling factors and regulates numerous genes ..
  17. Fang X, Hou Z, Dai X, Chen C, Ge J, Shen H, et al. Special AT-rich sequence-binding protein 1 promotes cell growth and metastasis in colorectal cancer. World J Gastroenterol. 2013;19:2331-9 pubmed publisher
    To evaluate the expression of special AT-rich sequence-binding protein 1 (SATB1) gene in colorectal cancer and its role in colorectal cancer cell proliferation and invasion...
  18. Cai S, Lee C, Kohwi Shigematsu T. SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat Genet. 2006;38:1278-88 pubmed
    b>SATB1 (special AT-rich sequence binding protein 1) organizes cell type-specific nuclear architecture by anchoring specialized DNA sequences and recruiting chromatin remodeling factors to control gene transcription...
  19. Nakayama Y, Mian I, Kohwi Shigematsu T, Ogawa T. A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage. Cell Cycle. 2005;4:1099-106 pubmed
    b>SATB1 is a nuclear protein, which acts as a cell-type specific genome organizer and gene regulator essential for T cell differentiation and activation. Several functional domains of SATB1 have been identified...
  20. Chu S, Ma Y, Feng D, Zhang H, Zhu Z, Li Z, et al. Upregulation of SATB1 is associated with the development and progression of glioma. J Transl Med. 2012;10:149 pubmed publisher
    Special AT-rich sequence-binding protein-1 (SATB1) has been reported to be expressed in several human cancers and may have malignant potential...
  21. Kumar P, Purbey P, Ravi D, Mitra D, Galande S. Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells. Mol Cell Biol. 2005;25:1620-33 pubmed
    ..Thymocytes from SATB1 (special AT-rich sequence binding protein 1) knockout mice have been shown to ectopically express IL-2Ralpha, ..
  22. Mao L, Yang C, Wang J, Li W, Wen R, Chen J, et al. SATB1 is overexpressed in metastatic prostate cancer and promotes prostate cancer cell growth and invasion. J Transl Med. 2013;11:111 pubmed publisher
    Special AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as the global chromatin organizer to regulate chromatin structure and gene expression gene expression...
  23. Han B, Luan L, Xu Z, Wu B. Expression and biological roles of SATB1 in human bladder cancer. Tumour Biol. 2013;34:2943-9 pubmed publisher
    Special AT-rich sequence-binding protein-1 (SATB1) has been recently reported to be overexpressed in various cancers and associate with the malignant behavior of cancer cells...
  24. McInnes N, Sadlon T, Brown C, Pederson S, Beyer M, Schultze J, et al. FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells. Oncogene. 2012;31:1045-54 pubmed publisher
    ..We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. In particular, we demonstrate that SATB1 is not only a direct target of FOXP3 repression, but that FOXP3 also ..
  25. Peng Z, Yang D, Li X, Huang Y, Zhang G, Zhong K, et al. [Expression of special AT-rich sequence-binding protein 1 mRNA in hepatocellular carcinoma and its clinical significance]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:1207-11 pubmed
    To investigate the expression of special AT-rich sequence binding protein 1 (SATB1) mRNA in hepatocellular carcinoma (HCC) and explore its correlation to the clinicopathological features, surgical outcomes and metastasis of HCC...
  26. Chen H, Takahara M, Oba J, Xie L, Chiba T, Takeuchi S, et al. Clinicopathologic and prognostic significance of SATB1 in cutaneous malignant melanoma. J Dermatol Sci. 2011;64:39-44 pubmed publisher
    Special AT-rich sequence-binding protein-1 (SATB1), a new type of gene regulator, has been reported to be expressed in several human cancers and may have malignant potential...
  27. Nakagomi K, Kohwi Y, Dickinson L, Kohwi Shigematsu T. A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1. Mol Cell Biol. 1994;14:1852-60 pubmed
    The nuclear matrix attachment DNA (MAR) binding protein SATB1 is a sequence context-specific binding protein that binds in the minor groove, making virtually no contact with the DNA bases...
  28. Huang Y, Fan X, Qiu F, Wang Z. Genomics of hepatitis B virus-related hepatocellular carcinoma and adjacent noncancerous tissues with cDNA microarray. Chin Med J (Engl). 2011;124:2057-64 pubmed
    ..This study provided the gene expression profile of HBV-related HCC and presented differential expression patterns of SATB-1, TM4SF-1 and ST-14 between cancerous and noncancerous tissues in patients with HBV-related HCC. ..
  29. Yasui D, Miyano M, Cai S, Varga Weisz P, Kohwi Shigematsu T. SATB1 targets chromatin remodelling to regulate genes over long distances. Nature. 2002;419:641-5 pubmed
    ..b>SATB1 ('special AT-rich sequence binding 1'), a protein found predominantly in thymocytes, regulates genes by folding ..
  30. Kumar P, Bischof O, Purbey P, Notani D, Urlaub H, Dejean A, et al. Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. Nat Cell Biol. 2007;9:45-56 pubmed
    ..interacts with the matrix attachment region (MAR)-binding protein, special AT-rich sequence binding protein 1 (SATB1) to organize the major histocompatibility complex (MHC) class I locus into distinct higher-order chromatin-loop ..
  31. Lu X, Cheng C, Zhu S, Yang Y, Zheng L, Wang G, et al. SATB1 is an independent prognostic marker for gastric cancer in a Chinese population. Oncol Rep. 2010;24:981-7 pubmed
    Special AT-rich sequence binding protein 1 (SATB1), a new type of gene regulator, has been reported to express in various human cancers and may associate with the malignant potential...
  32. Tan J, Song J, Chen Y, Durrin L. Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1. Mol Cell Biol. 2010;30:2823-36 pubmed publisher
    Special AT-rich sequence-binding protein 1 (SATB1) is a tissue-restricted genome organizer that provides a key link between DNA loop organization, chromatin modification/remodeling, and transcription factor association at matrix ..
  33. Zhao X, Wang P. [Expression of SATB1 and BRMS1 in ovarian serous adenocarcinoma and its relationship with clinieopathological features]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2011;42:82-5, 105 pubmed
    To study the expression and clinical significance of SATB1, BRMS1 in Ovarian serous adenocarcinoma...
  34. Xu L, Deng H, Xia J, Yang Y, Fan C, Hung W, et al. Assignment of SATB1 to human chromosome band 3p23 by in situ hybridization. Cytogenet Cell Genet. 1997;77:205-6 pubmed
  35. Shukla S, Sharma H, Abbas A, MacLennan G, Fu P, Danielpour D, et al. Upregulation of SATB1 is associated with prostate cancer aggressiveness and disease progression. PLoS ONE. 2013;8:e53527 pubmed publisher
    ..Recently, Special AT-rich binding protein (SATB1) has been linked to tumor progression...
  36. Li Q, Chen Z, Xu J, Cao X, Chen Q, Liu X, et al. Overexpression and involvement of special AT-rich sequence binding protein 1 in multidrug resistance in human breast carcinoma cells. Cancer Sci. 2010;101:80-6 pubmed publisher
    ..Here we found that SATB1 expression is upregulated in multidrug-resistant breast cancer cells that exhibit higher invasive potential than ..
  37. Iorns E, Hnatyszyn H, Seo P, Clarke J, Ward T, Lippman M. The role of SATB1 in breast cancer pathogenesis. J Natl Cancer Inst. 2010;102:1284-96 pubmed publisher
    b>SATB1 has been previously proposed as a key protein that controls the development and progression of breast cancer. We explored the potential of the SATB1 protein as a therapeutic target and prognostic marker for human breast cancer...
  38. Burute M, Gottimukkala K, Galande S. Chromatin organizer SATB1 is an important determinant of T-cell differentiation. Immunol Cell Biol. 2012;90:852-9 pubmed publisher
    ..In this review, we focus on the role of the T lineage-enriched chromatin organizer and regulator SATB1 in T-cell differentiation...
  39. Tu W, Luo M, Wang Z, Yan W, Xia Y, Deng H, et al. Upregulation of SATB1 promotes tumor growth and metastasis in liver cancer. Liver Int. 2012;32:1064-78 pubmed publisher
    Special AT-rich binding protein-1 (SATB1) reprograms chromatin organization and transcription profiles to promote tumour growth and metastasis...
  40. Lei L, Lu L, Xiang L, Xue Song W, De Pei L, Chih Chuan L. Epigenetic repression of SATB1 by polycomb group protein EZH2 in epithelial cells. Chin Med Sci J. 2010;25:199-205 pubmed
    To study the regulatory mechanism of SATB1 repression in cells other than T cells or erythroid cells, which have high expression level of SATB1...
  41. Selinger C, Cooper W, Al Sohaily S, Mladenova D, Pangon L, Kennedy C, et al. Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. J Thorac Oncol. 2011;6:1179-89 pubmed publisher
    ..Special AT-rich binding protein 1 (SATB1) is a global genome organizer that recruits chromatin remodeling proteins to epigenetically regulate hundreds of ..
  42. Li K, Cai R, Dai B, Zhang X, Wang H, Ge S, et al. SATB1 regulates SPARC expression in K562 cell line through binding to a specific sequence in the third intron. Biochem Biophys Res Commun. 2007;356:6-12 pubmed
    Special AT-rich binding protein 1 (SATB1), a cell type-specific nuclear matrix attachment region (MAR) DNA-binding protein, tethers to a specific DNA sequence and regulates gene expression through chromatin remodeling and HDAC (histone ..
  43. Lv J, Wang F, Shen M, Wang X, Zhou X. SATB1 expression is correlated with β-catenin associated epithelial-mesenchymal transition in colorectal cancer. Cancer Biol Ther. 2016;17:254-61 pubmed publisher
    b>SATB1, a global gene regulator, has been implicated in the growth and metastasis of multiple cancers, including colorectal cancer. While the understanding about the role of SATB1 in CRC remains limited...
  44. Haug A, Braun K, Ehnert S, Mayer L, Stöckle U, Nussler A, et al. Gene expression changes in cancellous bone of type 2 diabetics: a biomolecular basis for diabetic bone disease. Langenbecks Arch Surg. 2014;399:639-47 pubmed publisher
    ..Furthermore, the analysis of key differentiation factors of osteoblasts revealed significant alterations in gene expression of these factors, which may contribute to the dysregulation of energy metabolism in 2DM. ..
  45. Gong J, Tu W, Han J, He J, Liu J, Han P, et al. Hepatic SATB1 induces paracrine activation of hepatic stellate cells and is upregulated by HBx. Sci Rep. 2016;6:37717 pubmed publisher
    ..Special AT-rich binding protein 1 (SATB1) has been implicated in reprogramming chromatin organization and transcription profiles in many cancers and non-..
  46. Goolam M, Zernicka Goetz M. The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo. Development. 2017;144:1450-1461 pubmed publisher
    ..Here, we identify a chromatin modifier, Satb1, with a distinct role in this decision...
  47. Kim C, Lee G, Shin J, Jung S, Park B, Park N. Mutational analysis of SATB1 gene in hepatocellular carcinomas. APMIS. 2013;121:1012-4 pubmed publisher
  48. Mir R, Pradhan S, Galande S. Chromatin organizer SATB1 as a novel molecular target for cancer therapy. Curr Drug Targets. 2012;13:1603-15 pubmed
    ..Special AT-rich binding protein (SATB1) is a unique type of global regulator that integrates higher-order chromatin organization with regulation of gene ..
  49. Gocke C, Yu H, Kang J. Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. J Biol Chem. 2005;280:5004-12 pubmed
    ..Therefore, sumoylation appears to regulate the functions of its substrates through multiple, context-dependent mechanisms. ..
  50. Wang Y, Li X, Kong H, Zhu Q, Dong Y, Liu X, et al. Overexpression of SATB1 Gene Inhibits the Immunosuppressive Function of Regulatory T Cells in Chronic Hepatitis B. Ann Clin Lab Sci. 2017;47:403-408 pubmed
    Special AT-rich sequence-binding protein 1 (SATB1) is a class of nuclear matrix binding protein expressed by T cells and plays an important role in regulatory T cells (Tregs) mediated immune regulation...
  51. Peng Y, Tran N, Krishnaswamy A, Kostadinov D, Martersteck E, Sanes J. Satb1 Regulates Contactin 5 to Pattern Dendrites of a Mammalian Retinal Ganglion Cell. Neuron. 2017;95:869-883.e6 pubmed publisher
    ..We found that the transcriptional regulator Satb1 is selectively expressed by ooDSGCs...
  52. Yu W, Ma Y, Shankar S, Srivastava R. Role of SATB2 in human pancreatic cancer: Implications in transformation and a promising biomarker. Oncotarget. 2016;7:57783-57797 pubmed publisher
    ..Our findings suggest that SATB2 can induce dedifferentiation by inducing stemness and may have a role in pancreatic carcinogenesis, and can be used as a diagnostic biomarker. ..
  53. Tesone A, Rutkowski M, Brencicova E, Svoronos N, Perales Puchalt A, Stephen T, et al. Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells. Cell Rep. 2016;14:1774-1786 pubmed publisher
    Special AT-rich sequence-binding protein 1 (Satb1) governs genome-wide transcriptional programs. Using a conditional knockout mouse, we find that Satb1 is required for normal differentiation of conventional dendritic cells (DCs)...
  54. Al Sohaily S, Henderson C, Selinger C, Pangon L, Segelov E, Kohonen Corish M, et al. Loss of special AT-rich sequence-binding protein 1 (SATB1) predicts poor survival in patients with colorectal cancer. Histopathology. 2014;65:155-63 pubmed publisher
    Special AT-rich sequence-binding protein 1 (SATB1) is a cell type-specific matrix attachment region binding protein, functioning as a global genome organizer...
  55. Zhang S, Gao X, Ma Y, Jiang J, Dai Z, Yin X, et al. Expression and significance of SATB1 in the development of breast cancer. Genet Mol Res. 2015;14:3309-17 pubmed publisher
    Special AT-rich sequence binding protein 1 (SATB1) is a recently discovered gene regulator that can promote the growth and metastasis of breast cancer...
  56. Liu X, Zheng Y, Qiao C, Qv F, Wang J, Ding B, et al. Expression of SATB1 and HER2 in breast cancer and the correlations with clinicopathologic characteristics. Diagn Pathol. 2015;10:50 pubmed publisher
    Special AT-rich sequence binding protein 1 (SATB1) is found acting as a "genome organizer" that functions as a landing platform to regulate tissue-specific gene ex-pression...
  57. Wang Y, Su M, Zhou L, Tu P, Zhang X, Jiang X, et al. Deficiency of SATB1 expression in Sezary cells causes apoptosis resistance by regulating FasL/CD95L transcription. Blood. 2011;117:3826-35 pubmed publisher
    ..it was found that Sézary cells are deficient in the expression of special AT-rich region binding protein 1 (SATB1), a key regulator of T-cell development and maturation...
  58. Chu S, Ma Y, Feng D, Zhang H, Qiu J, Zhu Z, et al. Relationship between SATB1 expression and prognosis in astrocytoma. J Clin Neurosci. 2013;20:543-7 pubmed publisher
    Special AT-rich-sequence-binding protein 1 (SATB1), a new type of gene regulator, has been reported to be expressed in various human cancers and may be associated with malignancy...
  59. Grzanka A, Grzanka D, Gagat M, Tadrowski T, Sokołowska Wojdyło M, Marszałek A, et al. Correlation of SATB1 expression with clinical course of cutaneous T-cell lymphomas. Pol J Pathol. 2012;63:101-5 pubmed
    ..There are no specific prognostic factors in development of cutaneous lymphomas. SATB1 protein controls expression of many genes, including the cellular cycle and apoptosis...
  60. Guo L, Zheng J, Yu T, Liu Y, Duo L. Elevated expression of SATB1 is involved in pancreatic tumorigenesis and is associated with poor patient survival. Mol Med Rep. 2017;16:8842-8848 pubmed publisher
    Special AT?rich sequence?binding protein 1 (SATB1) is a master chromatin organizer which has been reported to be implicated in tumor progression in breast and lung cancer...
  61. Xiao T, Fu L, Jie Z. SATB1 overexpression correlates with gastrointestinal neoplasms invasion and metastasis: a meta-analysis for Chinese population. Oncotarget. 2017;8:48282-48290 pubmed publisher
    Gastrointestinal neoplasm (GIN) is the most common neoplasm in China. The global chromatin organizer SATB1 (special AT-rich sequence binding protein 1) is aberrantly expressed in multiple human neoplasms...
  62. Oda M, Kanoh Y, Watanabe Y, Masai H. Regulation of DNA replication timing on human chromosome by a cell-type specific DNA binding protein SATB1. PLoS ONE. 2012;7:e42375 pubmed publisher
    ..We show that Special AT-rich sequence Binding protein 1 (SATB1), specifically expressed in T-cells, binds to the early domain immediately adjacent to TTR and delays the ..