SAT2

Summary

Gene Symbol: SAT2
Description: spermidine/spermine N1-acetyltransferase family member 2
Alias: SSAT2, diamine acetyltransferase 2, diamine N-acetyltransferase 2, polyamine N-acetyltransferase 2, spermidine/spermine N(1)-acetyltransferase 2, thialysine N-epsilon-acetyltransferase
Species: human
Products:     SAT2

Top Publications

  1. Poulin M, Zhou J, Yan L, Shioda T. Pyrosequencing Methylation Analysis. Methods Mol Biol. 2018;1856:283-296 pubmed publisher
    ..methylation screening results, and global methylation analysis using repetitive elements including LINE-1, Alu, and Sat2. Pyrosequencing reproducibility and accuracy result in low measurement variance, thereby increasing the likelihood ..
  2. Maree F, Nsamba P, Mutowembwa P, Rotherham L, Esterhuysen J, Scott K. Intra-serotype SAT2 chimeric foot-and-mouth disease vaccine protects cattle against FMDV challenge. Vaccine. 2015;33:2909-16 pubmed publisher
    ..Here, we investigated an intra-serotype chimeric virus, vSAT2(ZIM14)-SAT2, which was engineered by replacing the surface-exposed capsid-coding region (1B-1D/2A) of a SAT2 genome-length ..
  3. Kotecha A, Perez Martín E, Harvey Y, Zhang F, Ilca S, Fry E, et al. Chimeric O1K foot-and-mouth disease virus with SAT2 outer capsid as an FMD vaccine candidate. Sci Rep. 2018;8:13654 pubmed publisher
    ..Here we report the construction of a chimeric clone between the SAT2 and O serotypes, designed to have SAT2 antigenicity...
  4. Marei W, Alvarez M, Van Hoeck V, Gutierrez Adan A, Bols P, Leroy J. Effect of nutritionally induced hyperlipidaemia on in vitro bovine embryo quality depends on the type of major fatty acid in the diet. Reprod Fertil Dev. 2017;29:1856-1867 pubmed publisher
    ..for carry-over effects: Group A was fed CONT, SAT1 and then UNSAT2, whereas Group B was fed CONT, UNSAT1 and then SAT2. Serum was collected after each dietary period, analysed and tested in bovine in vitro embryo culture...
  5. Velázquez Villegas L, López Barradas A, Torres N, Hernández Pando R, León Contreras J, Granados O, et al. Prolactin and the dietary protein/carbohydrate ratio regulate the expression of SNAT2 amino acid transporter in the mammary gland during lactation. Biochim Biophys Acta. 2015;1848:1157-64 pubmed publisher
    The sodium coupled neutral amino acid transporter 2 (SNAT2/SAT2/ATA2) is expressed in the mammary gland (MG) and plays an important role in the uptake of alanine and glutamine which are the most abundant amino acids transported into this ..
  6. Opperman P, Rotherham L, Esterhuysen J, Charleston B, Juleff N, Capozzo A, et al. Determining the epitope dominance on the capsid of a serotype SAT2 foot-and-mouth disease virus by mutational analyses. J Virol. 2014;88:8307-18 pubmed publisher
    ..For FMDV SAT2 viruses, studies have shown that at least two antigenic sites exist...
  7. Bertram M, Delgado A, Pauszek S, Smoliga G, Brito B, Stenfeldt C, et al. Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon. Prev Vet Med. 2018;155:1-10 pubmed publisher
    ..Four serotypes of FMD virus (FMDV; O, A, SAT1, SAT2) circulate in Cameroon, and a trivalent inactivated vaccine against the three most common serotypes (O, A, SAT2) ..
  8. Elhaig M, Elsheery M. Molecular investigation of foot-and-mouth disease virus in domestic bovids from Gharbia, Egypt. Trop Anim Health Prod. 2014;46:1455-62 pubmed publisher
    ..The diagnostic sensitivity of two RT-PCR assays for the detection of FMDV was evaluated. The results revealed that SAT2 was the causative agent. The percentage of infected of animals varied with the detection method, ranging from 62...
  9. Obinata H, Sugimoto A, Niwa S. Streptothricin acetyl transferase 2 (Sat2): A dominant selection marker for Caenorhabditis elegans genome editing. PLoS ONE. 2018;13:e0197128 pubmed publisher
    ..transformation based on nourseothricin (NTC) and its resistance-encoding gene, streptothricin-acetyl transferase 2 (Sat2)...

More Information

Publications56

  1. Lyons N, Stärk K, van Maanen C, Thomas S, Chepkwony E, Sangula A, et al. Epidemiological analysis of an outbreak of foot-and-mouth disease (serotype SAT2) on a large dairy farm in Kenya using regular vaccination. Acta Trop. 2015;143:103-11 pubmed publisher
    ..August-September 2012, an outbreak of Foot-and-mouth Disease (FMD) due to serotype Southern African Territories-2 (SAT2) occurred on a large, extensively grazed dairy farm in Nakuru County, Kenya. Over 29 days, 400/644 (62...
  2. Yang Y, Jin Z, Dong R, Zheng C, Huang Y, Zheng Y, et al. MicroRNA-29b/142-5p contribute to the pathogenesis of biliary atresia by regulating the IFN-? gene. Cell Death Dis. 2018;9:545 pubmed publisher
    ..Meanwhile, the methylation of the LINE-1, ALU and SAT2 repetitive sequences and the IFN-? promoter was lower, but the expression of IFN-? was upregulated...
  3. Neale R, Clark P, Fawcett J, Fritschi L, Nagler B, Risch H, et al. Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer. Cancer Epidemiol. 2014;38:576-82 pubmed publisher
    ..cancer cases (n=559) and healthy unrelated controls (n=603) were tested for methylation of the LINE-1, Alu and Sat2 DNA repetitive elements using MethyLight quantitative PCR assays...
  4. Hamdy M, Del Carlo M, Hussein H, Salah T, El Deeb A, Emara M, et al. Development of gold nanoparticles biosensor for ultrasensitive diagnosis of foot and mouth disease virus. J Nanobiotechnology. 2018;16:48 pubmed publisher
    ..and sensitive recognition of 31 Egyptian FMDV clinical isolates that represents the three FMDV serotypes (O, A, and SAT2)...
  5. Lyons N, Alexander N, Stärk K, Dulu T, Sumption K, James A, et al. Impact of foot-and-mouth disease on milk production on a large-scale dairy farm in Kenya. Prev Vet Med. 2015;120:177-86 pubmed publisher
    ..animal data from a large-scale dairy farm in Kenya to estimate the impact of an FMD outbreak due to serotype SAT2 virus on milk yield...
  6. Rocha Gracia R, Cortés Cortés G, Lozano Zarain P, Bello F, Martínez Laguna Y, Torres C. Faecal Escherichia coli isolates from healthy dogs harbour CTX-M-15 and CMY-2 β-lactamases. Vet J. 2015;203:315-9 pubmed publisher
    ..aadA and aadA/aadB arrays were detected in three isolates) and one isolate carried a class 2 integron (dfrA12-sat2-aadA1). The aac(6')Ib-cr, aac(3)-II, qnrB19, tet(A), tet(B), cmlA, and sul3 genes were also detected...
  7. Nsamba P, de Beer T, Chitray M, Scott K, Vosloo W, Maree F. Determination of common genetic variants within the non-structural proteins of foot-and-mouth disease viruses isolated in sub-Saharan Africa. Vet Microbiol. 2015;177:106-22 pubmed publisher
    ..Investigation of the amino acid heterogeneity of the non-structural proteins of seventy-nine FMDV isolates of SAT1, SAT2, SAT3, A and O serotypes revealed between 29 and 62% amino acid variability...
  8. Lyons N, Alexander N, StÓ“rk K, Dulu T, Rushton J, Fine P. Impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in Kenya. Vet Res. 2015;46:41 pubmed publisher
    ..A FMD (virus serotype SAT2) outbreak on a large-scale dairy farm in Nakuru County, Kenya provided an opportunity to evaluate the impact of FMD ..
  9. Leke R, Escobar T, Rao K, Silveira T, Norenberg M, Schousboe A. Expression of glutamine transporter isoforms in cerebral cortex of rats with chronic hepatic encephalopathy. Neurochem Int. 2015;88:32-7 pubmed publisher
    ..outcome, the aim of the present study was to investigate whether the expression of the glutamine transporters SAT1, SAT2, SN1 and SN2 would be affected in chronic HE...
  10. Nguyen A, Schneider J, Wendisch V. Elimination of polyamine N-acetylation and regulatory engineering improved putrescine production by Corynebacterium glutamicum. J Biotechnol. 2015;201:75-85 pubmed publisher
    ..However, cgmA overexpression in PUT21ΔsnaA did not further improve putrescine production, hence, the beneficial effects of both targets were not synergistic at the highest described yield of 0.21 g g(-1). ..
  11. Martini C, Michaux C, Bugli F, Arcovito A, Iavarone F, Cacaci M, et al. The polyamine N-acetyltransferase-like enzyme PmvE plays a role in the virulence of Enterococcus faecalis. Infect Immun. 2015;83:364-71 pubmed publisher
    ..Our results suggest that PmvE contributes to the virulence of E. faecalis, likely through its involvement in the polyamine metabolism. ..
  12. Arguello H, Guerra B, Rodríguez I, Rubio P, Carvajal A. Characterization of Antimicrobial Resistance Determinants and Class 1 and Class 2 Integrons in Salmonella enterica spp., Multidrug-Resistant Isolates from Pigs. Genes (Basel). 2018;9: pubmed publisher
    ..2), Salmonella Bredeney (1), and Salmonella Kapemba (1) harboured a class 2 integron 2300 bp estX-sat2-aadA1...
  13. Scott K, Rathogwa N, Capozzo A, Maree F. Evaluation of immune responses of stabilised SAT2 antigens of foot-and-mouth disease in cattle. Vaccine. 2017;35:5426-5433 pubmed publisher
    ..This is especially so for serotypes O and SAT2 which are unstable in mildly acidic pH conditions or at elevated temperatures leading to dissociation of the capsid ..
  14. Mostafa M, Siadat S, Shahcheraghi F, Vaziri F, Japoni Nejad A, Vand Yousefi J, et al. Variability in gene cassette patterns of class 1 and 2 integrons associated with multi drug resistance patterns in Staphylococcus aureus clinical isolates in Tehran-Iran. BMC Microbiol. 2015;15:152 pubmed publisher
    ..Gene cassette arrays aadB, aadA2 and dhfrA1-sat2-aadA1 were common in S.aureus isolates...
  15. Moen M, Fjær R, Hamdani E, Laerdahl J, Menchini R, Vigeland M, et al. Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport. Brain. 2016;139:3109-3120 pubmed
    ..cells in a K+ dependent manner and regulates activity of the neuronal glutamine transporter SAT2 (Slc38a2), while the F232fs variant impairs K+ fluxes and obliterates SAT2-dependent glutamine transport...
  16. Chitray M, Grazioli S, Willems T, Tshabalala T, De Vleeschauwer A, Esterhuysen J, et al. Development and validation of a foot-and-mouth disease virus SAT serotype-specific 3ABC assay to differentiate infected from vaccinated animals. J Virol Methods. 2018;255:44-51 pubmed publisher
    ..and IZSLER-NSP), using panels of field and experimental sera, vaccinated and/or infected with FMDV SAT1, SAT2 or SAT3...
  17. Zou W, Li C, Yang X, Wang Y, Cheng G, Zeng J, et al. Frequency of antimicrobial resistance and integron gene cassettes in Escherichia coli isolated from giant pandas (Ailuropoda melanoleuca) in China. Microb Pathog. 2018;116:173-179 pubmed publisher
    ..However, only one gene cassette (dfrA1-sat2-aadA1) was detected in class 2 integron. These finding emphasize that a high level of E...
  18. Awad A, Arafat N, Elhadidy M. Genetic elements associated with antimicrobial resistance among avian pathogenic Escherichia coli. Ann Clin Microbiol Antimicrob. 2016;15:59 pubmed
    ..dfrA1, dfrA5, dfrA7, dfrA12), streptomycin/spectinomycin (aadA1, aadA2, aadA5, aadA23), and streptothricin (sat2). To our knowledge, this the first description of the presence of aadA23 in APEC isolates...
  19. Xian Y, Wu M, Liu Y, Hao J, Wu Y, Liao X, et al. Increased Sat2 expression is associated with busulfan-induced testicular Sertoli cell injury. Toxicol In Vitro. 2017;43:47-57 pubmed publisher
    ..Here, we showed that spermidine/spermine N1-acetyltransferase 2 (Sat2) was present in testicular Sertoli cells, and its expression was significantly increased by busulfan treatment...
  20. He W, Liu Y, Geng H, Li Y. The regulation effect of ulinastatin on the expression of SSAT2 and AQP4 in myocardial tissue of rats after cardiopulmonary resuscitation. Int J Clin Exp Pathol. 2015;8:10792-9 pubmed
    ..the regulation effects of ulinastatin (UT1) on the expression of spermidine/spermine -N1-acetyltransferase 2 (SSAT2) and aquaporin 4 (AQP4) in myocardial tissue of rats after cardiopulmonary resuscitation (CPR) and their ..
  21. Chen D, Zhang X, Zhang Y, Zhang L, Ma J, You W, et al. Hypomethylation of repetitive elements in blood leukocyte DNA and risk of gastric lesions in a Chinese population. Cancer Epidemiol. 2016;41:122-8 pubmed publisher
    To explore the association between hypomethylation of repetitive elements (LINE-1, Sat2, and ALU) in blood leukocyte DNA and risks of gastric lesions, and development of gastric cancer (GC), a population-based study was conducted in a ..
  22. Bachanek Bankowska K, Mero H, Wadsworth J, Mioulet V, Sallu R, Belsham G, et al. Development and evaluation of tailored specific real-time RT-PCR assays for detection of foot-and-mouth disease virus serotypes circulating in East Africa. J Virol Methods. 2016;237:114-120 pubmed publisher
    ..AFRICA, lineage G-I), serotype O (topotypes EA-2 and EA-4), serotype SAT 1 (topotype I (NWZ)) and serotype SAT2 (topotype IV) were correctly identified with these rRT-PCR assays...
  23. Wu H, Xia S, Bu F, Qi J, Liu Y, Xu H. Identification of integrons and phylogenetic groups of drug-resistant Escherichia coli from broiler carcasses in China. Int J Food Microbiol. 2015;211:51-6 pubmed publisher
    ..and dfrA12-orfF-aadA2 in the variable region of class 1 integrons, while only one gene cassette array (dfrA1-sat2-aadA1) was detected in the variable region of class 2 integrons...
  24. Abdela N. Sero-prevalence, risk factors and distribution of foot and mouth disease in Ethiopia. Acta Trop. 2017;169:125-132 pubmed publisher
    ..In Ethiopia endemic distributions of five of seven serotypes, namely serotypes O, A, C, SAT1 and SAT2 have been documented...
  25. Soliman A, Ahmed A, Shimamoto T, el Domany R, Nariya H, Shimamoto T. First report in Africa of two clinical isolates of Proteus mirabilis carrying Salmonella genomic island (SGI1) variants, SGI1-PmABB and SGI1-W. Infect Genet Evol. 2017;51:132-137 pubmed publisher
    ..Furthermore, PmTAN59 carried class 2 integron of ~2.2kb containing dfrA1-sat2-aadA1. An ERIC-PCR analysis detected no clonal relationship between the two strains...
  26. Keller M, Gatti D, Schueler K, Rabaglia M, Stapleton D, Simecek P, et al. Genetic Drivers of Pancreatic Islet Function. Genetics. 2018;209:335-356 pubmed publisher
    ..as three genes with nominal association with diabetes-related traits in humans (FAM83E, IL6ST, and SAT2)...
  27. Siqueira A, Michael G, Domingos D, Ferraz M, Ribeiro M, Schwarz S, et al. Diversity of class 1 and 2 integrons detected in Escherichia coli isolates from diseased and apparently healthy dogs. Vet Microbiol. 2016;194:79-83 pubmed publisher
    ..Class 2 integrons carried the array dfrA1-sat2-aadA30...
  28. Scott K, Kotecha A, Seago J, Ren J, Fry E, Stuart D, et al. SAT2 Foot-and-Mouth Disease Virus Structurally Modified for Increased Thermostability. J Virol. 2017;91: pubmed publisher
    ..temperature, ionic, and pH stability by using Thermofluor and inactivation assays in order to evaluate potential SAT2 vaccine candidates with improved stability...
  29. Van Borm S, Rosseel T, Haegeman A, Fana M, Seoke L, Hyera J, et al. Complete Genome Sequences of Three African Foot-and-Mouth Disease Viruses from Clinical Samples Isolated in 2009 and 2010. Genome Announc. 2016;4: pubmed publisher
    The complete genome sequences of three foot-and-mouth disease viruses (one virus of each serotype SAT1, SAT2 and O) were directly sequenced from RNA extracted from clinical bovine samples, demonstrating the feasibility of full-genome ..
  30. Taitt C, Leski T, Heang V, Ford G, Prouty M, Newell S, et al. Antimicrobial resistance genotypes and phenotypes from multidrug-resistant bacterial wound infection isolates in Cambodia. J Glob Antimicrob Resist. 2015;3:198-204 pubmed publisher
    ..quinolones [qnrS (14%) and qnrB (5%)], sulfonamides [sul1 (29%), sul2 (38%) and sul3 (10%)], streptothricin (sat2) and trimethoprim (6 genes)...
  31. Wu H, Wang M, Liu Y, Wang X, Wang Y, Lu J, et al. Characterization of antimicrobial resistance in Klebsiella species isolated from chicken broilers. Int J Food Microbiol. 2016;232:95-102 pubmed publisher
    ..Only one gene cassette array (dfrA1-sat2-aadA1) was detected in the class 2 integrons...
  32. Cortés Cortés G, Lozano Zarain P, Torres C, Alonso C, Ríos Torres A, Castañeda M, et al. Extended-spectrum ?-lactamase-producing Escherichia coli isolated from healthy humans in Mexico, including subclone ST131-B2-O25:H4-H30-Rx. J Glob Antimicrob Resist. 2017;9:130-134 pubmed publisher
    ..coli by PCR and sequencing, as well as gene cassette arrays in class 1 (dfrA17-aadA5) and class 2 (dfrA1-sat2-aadA1) integrons...
  33. Mouton L, Dekker A, Bleijenberg M, Blanchet M, Coco Martin J, Hudelet P, et al. A foot-and-mouth disease SAT2 vaccine protects swine against experimental challenge with a homologous virus strain, irrespective of mild pathogenicity in this species. Vaccine. 2018;36:2020-2024 pubmed publisher
    FMDV serotype SAT2 is most frequently associated with outbreaks in ruminants. However, the risk of it spreading from cattle to pigs cannot be excluded...
  34. Pacheco J, Smoliga G, O Donnell V, Brito B, Stenfeldt C, Rodriguez L, et al. Persistent Foot-and-Mouth Disease Virus Infection in the Nasopharynx of Cattle; Tissue-Specific Distribution and Local Cytokine Expression. PLoS ONE. 2015;10:e0125698 pubmed publisher
    ..Analysis of 28 distinct anatomic sites from 21 steers infected with FMDV serotype A, O or SAT2, had the highest prevalence of overall viral detection in the dorsal nasopharynx (80...
  35. Lee S, Lee Y, Kim R, Park J, Park M, Ko M, et al. Rapid Engineering of Foot-and-Mouth Disease Vaccine and Challenge Viruses. J Virol. 2017;91: pubmed publisher
    ..strain O1/Manisa/Turkey/69 was replaced with the amplified or synthetic genes from the O, A, Asia1, C, SAT1, SAT2, and SAT3 serotypes. Viruses of the seven serotype were rescued successfully...
  36. Jeelani G, Sato D, Soga T, Nozaki T. Genetic, metabolomic and transcriptomic analyses of the de novo L-cysteine biosynthetic pathway in the enteric protozoan parasite Entamoeba histolytica. Sci Rep. 2017;7:15649 pubmed publisher
    ..strain showed impaired growth when cultured in a cysteine lacking BI-S-33 medium, whereas silencing of SAT1 and SAT2 had no effects on growth...
  37. Baek J, Liu Y, McDonald K, Wesley J, Zhang H, Semenza G. Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. J Biol Chem. 2007;282:33358-66 pubmed
    ..b>SSAT2 (spermidine/spermine N-acetyltransferase-2) binds to HIF-1alpha and promotes its ubiquitination/degradation by ..
  38. Chen Y, Vujcic S, Liang P, Diegelman P, Kramer D, Porter C. Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase. Biochem J. 2003;373:661-7 pubmed publisher
    ..The existence of an active, but possibly sequestered, SSAT-2 enzyme suggests that, under certain conditions, it may be recruited into basal or perturbed polyamine metabolism...
  39. Du N, Liu S, Niu M, Duan Y, Zhang S, Yao J, et al. Transmission and characterization of bla NDM-1 in Enterobacter cloacae at a teaching hospital in Yunnan, China. Ann Clin Microbiol Antimicrob. 2017;16:58 pubmed publisher
    ..aadA2, aadA5, aadB, aac(6')-Ib-cr), sulfamethoxazole/trimethoprim (dfrA17, dfrA12, dfrA15) and Streptozotocin (sat2). Six E. cloacae isolates belonged to ST74 and exhibited highly similar PFGE patterns...
  40. Baek J, Liu Y, McDonald K, Wesley J, Hubbi M, Byun H, et al. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. J Biol Chem. 2007;282:23572-80 pubmed
    ..b>SSAT2 binds to HIF-1alpha, VHL, and Elongin C and promotes ubiquitination of hydroxylated HIF-1alpha by stabilizing the ..
  41. Gornati R, Chini V, Rimoldi S, Meregalli M, Schiaffino E, Bernardini G. Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR. Mol Cell Biochem. 2007;298:59-68 pubmed
    ..Although this study is still preliminary, it opens a new possibility for neoplastic prognosis finding potential molecular markers among the mRNAs that codify for glycosyltransferases. ..
  42. Han B, Bingman C, Wesenberg G, Phillips G. Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A. Proteins. 2006;64:288-93 pubmed
  43. Coleman C, Stanley B, Jones A, Pegg A. Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. Biochem J. 2004;384:139-48 pubmed
    ..We have purified a recombinant human acetyltransferase (SSAT2) that shares 45% identity and 61% homology with human SSAT1, but is only distally related to other known members ..
  44. Araújo S, A T Silva I, Tacão M, Patinha C, Alves A, Henriques I. Characterization of antibiotic resistant and pathogenic Escherichia coli in irrigation water and vegetables in household farms. Int J Food Microbiol. 2017;257:192-200 pubmed publisher
    ..intI2 was detected in water (dfrA1-sat2-aadA1). Plasmids were detected in 14 isolates (IncFIC, IncFIB, IncFrep, IncI1 in both samples; IncY in vegetables)...
  45. Prescott J, Thompson D, Kraft P, Chanock S, Audley T, Brown J, et al. Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women. PLoS ONE. 2012;7:e37815 pubmed publisher
    ..Our results suggest that the small magnitude of difference in hormone levels associated with common genetic variants is likely insufficient to detectably contribute to breast cancer risk. ..
  46. Sun H, Liu B, Wang W, Jiang G, Li W, Yang Y, et al. Adenovirus-mediated expression of spermidine/spermine N1-acetyltransferase gene induces S-phase arrest in human colorectal cancer cells. Oncol Rep. 2008;20:1229-35 pubmed
  47. Yang X, Zou W, Zeng J, Xie S, An T, Luo X, et al. Prevalence of antimicrobial resistance and integron gene cassettes in Escherichia coli isolated from yaks (Poephagus grunniens) in Aba Tibetan Autonomous Prefecture, China. Microb Pathog. 2017;111:274-279 pubmed publisher
    ..The most prevalent gene cassette was aadA1 (20%). For the class 2 integron, dfrA1-sat2-aadA1 (6%) and dfrA1-sat1-aadA1 (0.4%) were also detected as part of this research...