SAR1A

Summary

Gene Symbol: SAR1A
Description: secretion associated Ras related GTPase 1A
Alias: SAR1, SARA1, Sara, masra2, GTP-binding protein SAR1a, COPII-associated small GTPase, SAR1 gene homolog A, SAR1 homolog A, SAR1a gene homolog 1
Species: human
Products:     SAR1A

Top Publications

  1. Jones B, Jones E, Bonney S, Patel H, Mensenkamp A, Eichenbaum Voline S, et al. Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat Genet. 2003;34:29-31 pubmed
    ..The Sar1 family of proteins initiates the intracellular transport of proteins in COPII (coat protein)-coated vesicles...
  2. Bi X, Mancias J, Goldberg J. Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31. Dev Cell. 2007;13:635-45 pubmed
    The COPII vesicular coat forms on the endoplasmic reticulum from Sar1-GTP, Sec23/24 and Sec13/31 protein subunits. Here, we define the interaction between Sec23/24.Sar1 and Sec13/31, involving a 40 residue Sec31 fragment...
  3. Long K, Yamamoto Y, Baker A, Watkins S, Coyne C, Conway J, et al. Sar1 assembly regulates membrane constriction and ER export. J Cell Biol. 2010;190:115-28 pubmed publisher
    The guanosine triphosphatase Sar1 controls the assembly and fission of COPII vesicles...
  4. Loftus A, Hsieh V, Parthasarathy R. Modulation of membrane rigidity by the human vesicle trafficking proteins Sar1A and Sar1B. Biochem Biophys Res Commun. 2012;426:585-9 pubmed publisher
    ..measures in vitro membrane response to imposed deformations, we examined the behavior of the two human paralogs of Sar1, a key component of the COPII family of vesicle coat proteins...
  5. De Backer S, Sabirova J, De Pauw I, De Greve H, Hernalsteens J, Goossens H, et al. Enzymes Catalyzing the TCA- and Urea Cycle Influence the Matrix Composition of Biofilms Formed by Methicillin-Resistant Staphylococcus aureus USA300. Microorganisms. 2018;6: pubmed publisher
    ..analysis of fibronectin-binding proteins (fnbA/B) and the staphylococcal accessory regulator (sarA) on pre-formed UAS391-Erys and Tn-mutant biofilms showed: (i) < 1% PIA/PNAG in the proteinaceous/..
  6. da Silva Carvalho G, Saute J, Haas C, Torrez V, Brochier A, Souza G, et al. Cytokines in Machado Joseph Disease/Spinocerebellar Ataxia 3. Cerebellum. 2016;15:518-25 pubmed publisher
    ..Age at onset, disease duration, and clinical scales Scale for the Assessment and Rating of Ataxia (SARA), Neurological Examination Score for Spinocerebellar Ataxias (NESSCA), SCA Functional Index (SCAFI), and Composite ..
  7. Chen H, Yang T, Wang M, Chen D, Yang Y, Zhao Y. Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-?-mediated Smad3 phosphorylation. Phytomedicine. 2018;42:207-218 pubmed publisher
    ..analysis indicated that MAF selectively blocked the combination of Smad3 with TGF?RI and Smad3 with SARA without interfering with the Smad2, TGF?RI and SARA interaction...
  8. Humer E, Petri R, Aschenbach J, Bradford B, Penner G, Tafaj M, et al. Invited review: Practical feeding management recommendations to mitigate the risk of subacute ruminal acidosis in dairy cattle. J Dairy Sci. 2018;101:872-888 pubmed publisher
    ..These diets, however, can impair rumen health. The term "subacute ruminal acidosis" (SARA) is often used as a synonym for poor rumen health...
  9. Szafranska A, Oxley A, Chaves Moreno D, Horst S, Roßlenbroich S, Peters G, et al. High-resolution transcriptomic analysis of the adaptive response of Staphylococcus aureus during acute and chronic phases of osteomyelitis. MBio. 2014;5: pubmed publisher
    ..At the regulatory level, sarA and -R and saeR and -S as well as the small RNA RsaC were predominantly expressed by S...

More Information

Publications127 found, 100 shown here

  1. Brocklehurst P, Field D, Greene K, Juszczak E, Kenyon S, Linsell L, et al. Computerised interpretation of the fetal heart rate during labour: a randomised controlled trial (INFANT). Health Technol Assess. 2018;22:1-186 pubmed publisher
    ..22, No. 9. See the NIHR Journals Library website for further project information. Sara Kenyon was part funded by the NIHR Collaboration for Leadership in Applied Health Research and Care West Midlands.
  2. Lazareva E, Lezzhov A, Golyshev S, Morozov S, Heinlein M, Solovyev A. Similarities in intracellular transport of plant viral movement proteins BMB2 and TGB3. J Gen Virol. 2017;98:2379-2391 pubmed publisher
    ..Inhibition of COPII budding complex formation by the expression of a dominant-negative mutant of the small GTPase Sar1 had no detectable effect on BMB2 subcellular targeting, which therefore could occur without exit from the ER in ..
  3. Tranchemontagne Z, Camire R, O Donnell V, Baugh J, Burkholder K. Staphylococcus aureus Strain USA300 Perturbs Acquisition of Lysosomal Enzymes and Requires Phagosomal Acidification for Survival inside Macrophages. Infect Immun. 2016;84:241-53 pubmed publisher
    ..reduction in USA300 expression of the staphylococcal virulence regulator agr but had little effect on expression of sarA, saeR, or sigB. Bacterial exposure to acidic pH in vitro increased agr expression...
  4. Colver A, Rapp M, Eisemann N, Ehlinger V, Thyen U, Dickinson H, et al. Self-reported quality of life of adolescents with cerebral palsy: a cross-sectional and longitudinal analysis. Lancet. 2015;385:705-16 pubmed publisher
    ..University of Lübeck E40-2009 and E26-2010 (Germany); CNSA, INSERM, MiRe-DREES, and IRESP (France); Ludvig and Sara Elsass Foundation, The Spastics Society and Vanforefonden (Denmark); Cooperativa Sociale "Gli Anni in Tasca" and ..
  5. Kato S, Chen J, Cornog K, Zhang H, Roberts J. The Golgi apparatus regulates cGMP-dependent protein kinase I compartmentation and proteolysis. Am J Physiol Cell Physiol. 2015;308:C944-58 pubmed publisher
    ..ER protein transport influences PKGI localization because overexpression of a constitutively inactive Sar1 transgene caused PKGI retention in the ER...
  6. Xu T, Tao H, Chang G, Zhang K, Xu L, Shen X. Lipopolysaccharide derived from the rumen down-regulates stearoyl-CoA desaturase 1 expression and alters fatty acid composition in the liver of dairy cows fed a high-concentrate diet. BMC Vet Res. 2015;11:52 pubmed publisher
    ..diet to meet lactating demands, yet long-term concentrate feeding induces subacute ruminal acidosis (SARA) and leads to a decrease in milk fat...
  7. Ersoy S, Abdelhady W, Li L, Chambers H, Xiong Y, Bayer A. Bicarbonate Resensitization of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics. Antimicrob Agents Chemother. 2019;: pubmed publisher
    ..NaHCO3 reduced expression of two key genes involved in the MRSA phenotype, mecA and sarA, leading to decreased production of penicillin-binding protein (PBP) 2a (that mediates methicillin resistance), ..
  8. Ray K. Calcium-Sensing Receptor: Trafficking, Endocytosis, Recycling, and Importance of Interacting Proteins. Prog Mol Biol Transl Sci. 2015;132:127-50 pubmed publisher
    ..e., G-proteins, protein kinases, inositol phosphates, etc.) and include small molecular weight G-proteins (Sar1, Rabs, ARF, P24A, RAMPs, filamin A, 14-3-3 proteins, calmodulin, and caveolin-1)...
  9. Yang B, Lei Z, Zhao Y, Ahmed S, Wang C, Zhang S, et al. Combination Susceptibility Testing of Common Antimicrobials in Vitro and the Effects of Sub-MIC of Antimicrobials on Staphylococcus aureus Biofilm Formation. Front Microbiol. 2017;8:2125 pubmed publisher
    ..aureus biofilm-related genes such as sarA, fnbA, rbf, lrgA, cidA, and eno after the treatment at sub-MIC with all of the six antimicrobials...
  10. Sanni S, Lyngsø C, Gammeltoft S, Hansen J. SII Ang II Potentiates Insulin Receptor Signalling and Glycogen Synthesis in Hepatocytes. Basic Clin Pharmacol Toxicol. 2017;: pubmed publisher
    ..Functionally selective Ang II analogues, such as the [Sar1, Ile4, Ile8]-angiotensin II (SII Ang II) analogue that only activates a subset of signalling networks have been ..
  11. Djami Tchatchou A, Ncube E, Steenkamp P, Dubery I. Similar, but different: structurally related azelaic acid and hexanoic acid trigger differential metabolomic and transcriptomic responses in tobacco cells. BMC Plant Biol. 2017;17:227 pubmed publisher
    ..phenylpropanoid pathway and chlorogenic acids metabolism, while ethylene response element-binding protein, small sar1 GTPase, heat shock protein 90, RAR1, SGT1, non-expressor of PR genes 1 and thioredoxin were analyzed to report on ..
  12. Alarcon P, Manosalva C, Carretta M, Hidalgo A, Figueroa C, Taubert A, et al. Fatty and hydroxycarboxylic acid receptors: The missing link of immune response and metabolism in cattle. Vet Immunol Immunopathol. 2018;201:77-87 pubmed publisher
    ..For instance, increased SCFA and lactate levels are associated with subacute ruminal acidosis (SARA) and the activation of pro-inflammatory processes mediated by diverse leukocyte and vascular endothelial cells...
  13. Kovalchuk V, Samluk Ł, Juraszek B, Jurkiewicz Trząska D, Sucic S, Freissmuth M, et al. Trafficking of the amino acid transporter B0,+ (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum. Biochim Biophys Acta Mol Cell Res. 2019;1866:252-263 pubmed publisher
    ..The expression of ATB0,+ at the plasma membrane was decreased by dominant negative mutants of SAR1, a GTPase, whose activity triggers the formation of the COPII complex...
  14. Carretta M, Hidalgo A, Burgos J, Opazo L, Castro L, Hidalgo M, et al. Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. Vet Immunol Immunopathol. 2016;176:18-27 pubmed publisher
    Increased short-chain fatty acid (SCFA) production is associated with subacute ruminal acidosis (SARA) and activation of inflammatory processes...
  15. Choe D, Szubin R, Dahesh S, Cho S, Nizet V, Palsson B, et al. Genome-scale analysis of Methicillin-resistant Staphylococcus aureus USA300 reveals a tradeoff between pathogenesis and drug resistance. Sci Rep. 2018;8:2215 pubmed publisher
    ..measurement of differential gene expression revealed the regulatory framework of the virulence regulator Agr, the SarA-family transcriptional regulators, and β-lactam resistance regulators...
  16. Ushijima Y, Ohniwa R, Morikawa K. Identification of nucleoid associated proteins (NAPs) under oxidative stress in Staphylococcus aureus. BMC Microbiol. 2017;17:207 pubmed publisher
    ..csNAPs under oxidative stress were the constitutive nucleoid components; importantly, several factors including HU, SarA, FabZ, and ribosomes were sustained under oxidative stress. Some factors (e.g...
  17. Christo Foroux E, Vallaeys T, Loux V, Dassa E, Deutscher J, Wandersman C, et al. Manual and expert annotation of the nearly complete genome sequence of Staphylococcus sciuri strain ATCC 29059: A reference for the oxidase-positive staphylococci that supports the atypical phenotypic features of the species group. Syst Appl Microbiol. 2017;40:401-410 pubmed publisher
    ..of two-component regulatory systems and a complete panel of master regulators, such as agr, rex, mgrA, rot, sarA and sarR genes, depict the background in which S. aureus virulence genes were later acquired...
  18. Rowe S, Campbell C, Lowry C, O Donnell S, Olson M, Lindgren J, et al. AraC-Type Regulator Rbf Controls the Staphylococcus epidermidis Biofilm Phenotype by Negatively Regulating the icaADBC Repressor SarR. J Bacteriol. 2016;198:2914-2924 pubmed
    ..Recombinant Rbf bound to the sarR promoter and not the sarX, sarA, sarZ, spx, and srrA promoters...
  19. van Schooten B, Jiggins C, Briscoe A, Papa R. Genome-wide analysis of ionotropic receptors provides insight into their evolution in Heliconius butterflies. BMC Genomics. 2016;17:254 pubmed publisher
    ..dN/dS analysis suggests more frequent positive selection in some intronless IR genes and in particular in the sara/sapho and melpomene/cydno/timareta clades...
  20. Thai V, Lim T, Le K, Lin Q, Nguyen T. iTRAQ-based proteome analysis of fluoroquinolone-resistant Staphylococcus aureus. J Glob Antimicrob Resist. 2017;8:82-89 pubmed publisher
    ..proteins 1 and 2, immunoglobulin-binding protein Sbi, triosephosphate isomerase, enolase, EsxA, SaeR, SarA, MgrA) and the stress response (alkyl hydroperoxide reductase subunit C, ClpB, ClpC, ClpL, ClpX, HslU, l-lactate ..
  21. Odjidja E, Gatasi G, Durić P. Delivery of integrated infectious disease control services under the new antenatal care guidelines: a service availability and readiness assessment of health facilities in Tanzania. BMC Health Serv Res. 2019;19:153 pubmed publisher
    ..Using the WHO's service availability and readiness assessment(SARA) framework, this study assesses the capacity of the Tanzanian Health System to provide integrated Malaria, ..
  22. Dickens J, Ordonez A, Chambers J, Beckett A, Patel V, Malzer E, et al. The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-?1-antitrypsin. FASEB J. 2016;30:4083-4097 pubmed
    ..be transported between them in a cytosol-dependent fashion that is sensitive to N-ethylmaleimide and dependent on Sar1 and sec22B. We conclude that protein recycling occurs between ER inclusions despite their physical separation...
  23. Lee D, Shin Y, Park J, Park S, Hwang E, Yang J, et al. Alveolar Bone Protective Effect of Hiziki Extracts on the Progression of Periodontitis. Mar Biotechnol (NY). 2018;20:313-323 pubmed publisher
    ..of osteoblast markers, including transforming growth factor beta (TGF-?), SMAD anchor for receptor activation (SARA) and runt-related transcription factor 2 (RUNX2) in hDPL cells...
  24. Bakhoum N, Galiana A, Le Roux C, Kane A, Duponnois R, Ndoye F, et al. Phylogeny of nodulation genes and symbiotic diversity of Acacia senegal (L.) Willd. and A. seyal (Del.) Mesorhizobium strains from different regions of Senegal. Microb Ecol. 2015;69:641-51 pubmed publisher
    ..nodulation, total dry weight, acetylene reduction activity (ARA), and specific acetylene reduction activity (SARA) of plants...
  25. Kim S, Corvaglia A, Léo S, Cheung A, Francois P. Characterization of RNA Helicase CshA and Its Role in Protecting mRNAs and Small RNAs of Staphylococcus aureus Strain Newman. Infect Immun. 2016;84:833-44 pubmed publisher
    ..g., secY mRNA) and, surprisingly, an mRNA encoding a regulatory protein (i.e., sarA mRNA). We hypothesize that some mRNAs may be protected by RNA-binding protein(s) from degradation by MazFsa...
  26. Nakagawa H, Hazama K, Ishida K, Komori M, Nishimura K, Matsuo S. Inhibition of PLD1 activity causes ER stress via regulation of COPII vesicle formation. Biochem Biophys Res Commun. 2017;490:895-900 pubmed publisher
    ..COPII vesicle coat proteins are composed of Sar1 as well as Sec23/24 and Sec13/31 complexes...
  27. Altan Bonnet N, Sougrat R, Liu W, Snapp E, Ward T, Lippincott Schwartz J. Golgi inheritance in mammalian cells is mediated through endoplasmic reticulum export activities. Mol Biol Cell. 2006;17:990-1005 pubmed
    ..Finally, reporters for Arf1 and Sar1 activity revealed that Arf1 and Sar1 undergo sequential inactivation during mitotic Golgi breakdown and sequential ..
  28. Llanos A, François J, Parrou J. Tracking the best reference genes for RT-qPCR data normalization in filamentous fungi. BMC Genomics. 2015;16:71 pubmed publisher
    ..This group included ubcB, sac7, fis1 and sarA genes, as well as TFC1 and UBC6 that were previously validated for their use in S. cerevisiae...
  29. Dong O, Meteignier L, Plourde M, Ahmed B, Wang M, Jensen C, et al. Arabidopsis TAF15b Localizes to RNA Processing Bodies and Contributes to snc1-Mediated Autoimmunity. Mol Plant Microbe Interact. 2016;29:247-57 pubmed publisher
    ..The Arabidopsis nuclear protein MOS11, along with the nucleoporins MOS3/Nup96/SAR3 and Nup160/SAR1 are components of the mRNA export machinery and contribute to immunity mediated by nucleotide binding leucine-rich ..
  30. Schären M, Seyfang G, Steingass H, Dieho K, Dijkstra J, Hüther L, et al. The effects of a ration change from a total mixed ration to pasture on rumen fermentation, volatile fatty acid absorption characteristics, and morphology of dairy cows. J Dairy Sci. 2016;99:3549-3565 pubmed publisher
    ..rumen pH assessments and LPS concentrations did not reveal an increased risk for subacute rumen acidosis (SARA) during the adaption period, histopathology of rumen papillae and potential for VFA absorption indicated a possible ..
  31. Tian P, Luo Y, Li X, Tian J, Tao S, Hua C, et al. Negative effects of long-term feeding of high-grain diets to lactating goats on milk fat production and composition by regulating gene expression and DNA methylation in the mammary gland. J Anim Sci Biotechnol. 2017;8:74 pubmed publisher
    ..known that feeding a high concentrate (HC) diet to lactating ruminants likely induces subacute ruminal acidosis (SARA) and leads to a decrease in milk fat production...
  32. Spina Tensini F, Sato M, Shiokawa N, Ashizawa T, Teive H. A Comparative Optical Coherence Tomography Study of Spinocerebellar Ataxia Types 3 and 10. Cerebellum. 2017;16:797-801 pubmed publisher
    ..They were submitted to OCT and clinical evaluation using SARA score. Expansion size, demographic data, time from disease onset, and age of onset were collected...
  33. Milne S, Murphy A, Georgiou Karistianis N, Yiu E, Delatycki M, Corben L. Psychometric properties of outcome measures evaluating decline in gait in cerebellar ataxia: A systematic review. Gait Posture. 2018;61:149-162 pubmed publisher
    ..and swing percentage of the gait cycle, velocity, step length and the Scale for Assessment and Rating of Ataxia (SARA) gait item as the most valid and responsive measures of gait in cerebellar ataxia...
  34. van der Walt A, Buzzard K, Sung S, Spelman T, Kolbe S, Marriott M, et al. The occurrence of dystonia in upper-limb multiple sclerosis tremor. Mult Scler. 2015;21:1847-55 pubmed publisher
    ..We rated tremor severity, writing and Archimedes spiral drawing; cerebellar dysfunction (SARA score); the Global Dystonia Scale (GDS) for proximal and distal upper limbs, dystonic posturing, mirror movements, ..
  35. Chang W, Ding D, Zhang S, Dai Y, Pan Q, Lu H, et al. Methicillin-Resistant Staphylococcus aureus Grown on Vancomycin-Supplemented Screening Agar Displays Enhanced Biofilm Formation. Antimicrob Agents Chemother. 2015;59:7906-10 pubmed publisher
    ..formation by hVISA may be mediated by FnbA- and polysaccharide intercellular adhesin-dependent pathways, and upregulation of atlA and sarA may also contribute to enhanced biofilm formation by hVISA upon prolonged exposure to vancomycin.
  36. Kirbaeva N, Sharanova N, Zhminchenko V, Toropygin I, Koplik E, Pertsov S, et al. Effect of Coenzyme Q10 on Proteomic Profile of Rat Brain Amygdala during Acute Metabolic Stress. Bull Exp Biol Med. 2016;161:460-4 pubmed publisher
    ..Differential expression of tropomodulin-2, GTP-binding protein SAR1, peroxiredoxin-2, calcineurin B homologous protein 1, Ras-related protein Rab-14, glutathione S-transferase omega-1,..
  37. Yeo W, Arya R, Kim K, Jeong H, Cho K, Bae T. The FDA-approved anti-cancer drugs, streptozotocin and floxuridine, reduce the virulence of Staphylococcus aureus. Sci Rep. 2018;8:2521 pubmed publisher
    ..RNA-seq analysis suggests that both compounds inhibit other virulence-regulatory systems such as Agr, ArlRS, and SarA more efficiently than they inhibit the Sae system. Both compounds induced prophages from S...
  38. Nie C, Wang H, Wang R, Ginsburg D, Chen X. Dimeric sorting code for concentrative cargo selection by the COPII coat. Proc Natl Acad Sci U S A. 2018;115:E3155-E3162 pubmed publisher
    ..The COPII complex, assembled by the activated SAR1 GTPases on the surface of the endoplasmic reticulum, orchestrates protein interactions to package cargos and ..
  39. Fu S, Octavia S, Tanaka M, Sintchenko V, Lan R. Defining the Core Genome of Salmonella enterica Serovar Typhimurium for Genomic Surveillance and Epidemiological Typing. J Clin Microbiol. 2015;53:2530-8 pubmed publisher
    ..Twenty-one S. Typhimurium strains from Salmonella reference collection A (SARA) were analyzed using Illumina high-throughput genome sequencing...
  40. Hamilton M, Hopkins L, AlZahal O, Macdonald T, Cervone D, Wright D, et al. Feeding butter with elevated content of trans-10, cis-12 conjugated linoleic acid to obese-prone rats impairs glucose and insulin tolerance. Lipids Health Dis. 2015;14:119 pubmed publisher
    ..prepared from milk collected from cows fed a high fermentable carbohydrate diet to create subacute rumen acidosis (SARA); control (non-SARA) butter was collected from cows fed a low grain diet...
  41. Lei L, Yang G, Wang J, Chuang D, Song W, Tang B, et al. Safety and efficacy of valproic acid treatment in SCA3/MJD patients. Parkinsonism Relat Disord. 2016;26:55-61 pubmed publisher
    ..Symptoms were evaluated using the Scale for Assessment and Rating of Ataxia (SARA). Multi-dose VPA treatment improved SARA measures of locomotor function...
  42. Grosser M, Weiss A, Shaw L, Richardson A. Regulatory Requirements for Staphylococcus aureus Nitric Oxide Resistance. J Bacteriol. 2016;198:2043-55 pubmed publisher
    ..aureus: three virulence regulons not formerly associated with NOË™ resistance, SarA, CodY, and Rot, as well as two regulons with established roles, Fur and SrrAB...
  43. Schubert J, Podkowik M, Bystroń J, Bania J. Production of staphylococcal enterotoxins in microbial broth and milk by Staphylococcus aureus strains harboring seh gene. Int J Food Microbiol. 2016;235:36-45 pubmed publisher
    ..In these strains hld, rot and sarA transcripts were up-regulated in milk as compared to weak SEH producers...
  44. Xu T, Seyfert H, Shen X. Epigenetic mechanisms contribute to decrease stearoyl-CoA desaturase 1 expression in the liver of dairy cows after prolonged feeding of high-concentrate diet. J Dairy Sci. 2018;101:2506-2518 pubmed publisher
    Subacute ruminal acidosis (SARA) of dairy cattle is a widely occurring but not very overt metabolic disorder thought to impair milk composition...
  45. Mickdam E, Khiaosa ard R, Metzler Zebeli B, Klevenhusen F, Chizzola R, Zebeli Q. Rumen microbial abundance and fermentation profile during severe subacute ruminal acidosis and its modulation by plant derived alkaloids in vitro. Anaerobe. 2016;39:4-13 pubmed publisher
    ..changes in rumen microbial abundances and fermentation profiles using a severe subacute ruminal acidosis (SARA) in vitro model, and to evaluate a potential modulatory role of plant derived alkaloids (PDA), containing ..
  46. Abdeen Z. Adsorption efficiency of poly(ethylene glycol)/chitosan/CNT blends for maltene fraction separation. Environ Sci Pollut Res Int. 2016;23:11240-6 pubmed publisher
    ..to adsorb and separate maltene fractions was compared using saturates, aromatics, resins, and asphaltenes (SARA) method...
  47. Callaghan M, McAuliffe P, Rodgers R, Hernandez Medrano J, Perry V. Subacute ruminal acidosis reduces sperm quality in beef bulls. J Anim Sci. 2016;94:3215-3228 pubmed
    Breeding bulls are commonly fed high-energy diets, which may induce subacute ruminal acidosis (SARA)...
  48. Saute J, Rieder C, Castilhos R, Monte T, Schumacher Schuh A, Donis K, et al. Planning future clinical trials in Machado Joseph disease: Lessons from a phase 2 trial. J Neurol Sci. 2015;358:72-6 pubmed publisher
    ..Score for the Assessment of Spinocerebellar Ataxia (NESSCA) and the Scale for the Assessment and Rating of Ataxia (SARA) subscores and with the subgroup of patients with independent gait according to the 8-meter walking-time (8MW)...
  49. Zeng Y, Chung K, Li B, Lai C, Lam S, Wang X, et al. Unique COPII component AtSar1a/AtSec23a pair is required for the distinct function of protein ER export in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2015;112:14360-5 pubmed publisher
    ..ER) to Golgi via the coat protein complex II (COPII) vesicle, which consists of five cytosolic components (Sar1, Sec23-24, and Sec13-31)...
  50. Petrera A, Gassenhuber J, Ruf S, Gunasekaran D, Esser J, Shahinian J, et al. Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels. J Transl Med. 2016;14:153 pubmed publisher
    ..24 h post-surgery, LAD-ligated animals were treated with daily doses of the cathepsin A inhibitor SAR1 or placebo. After 4 weeks, the three groups (sham, MI-placebo, MI-SAR1) were evaluated...
  51. Ahmed S, Chowdhury M, Khan M, Huq N, Naheed A. Access to primary health care for acute vascular events in rural low income settings: a mixed methods study. BMC Health Serv Res. 2017;17:47 pubmed publisher
    ..for AVE will be assessed through a health facility survey using 'service availability and readiness assessment' (SARA) tools of the World Health Organization (WHO)...
  52. Taneja T, Mankouri J, Karnik R, Kannan S, Smith A, Munsey T, et al. Sar1-GTPase-dependent ER exit of KATP channels revealed by a mutation causing congenital hyperinsulinism. Hum Mol Genet. 2009;18:2400-13 pubmed publisher
    ..concentration of the channel into COPII-enriched ER exit sites prior to ER export via a process that requires Sar1-GTPase...
  53. Matsushima M, Yabe I, Oba K, Sakushima K, Mito Y, Takei A, et al. Comparison of Different Symptom Assessment Scales for Multiple System Atrophy. Cerebellum. 2016;15:190-200 pubmed publisher
    ..Potential candidates are the Unified MSA Rating Scale (UMSARS), Scale for the Assessment and Rating of Ataxia (SARA), Berg Balance Scale (BBS), MSA Health-Related Quality of Life scale (MSA-QoL), and Scales for Outcomes in ..
  54. Verissimo F, Halavatyi A, Pepperkok R, Weiss M. A microtubule-independent role of p150glued in secretory cargo concentration at endoplasmic reticulum exit sites. J Cell Sci. 2015;128:4160-70 pubmed publisher
    ..COPII coat complex, which occurs at ER exit sites (ERES), is initiated by membrane association and GTP loading of SAR1, followed by the recruitment of the SEC23-SEC24 and SEC13-SEC31 subcomplexes...
  55. Yao K, Roberts R, Allard M, Hoffmann M. Complete Genome and Methylome Sequences of Salmonella enterica subsp. enterica Serovars Typhimurium, Saintpaul, and Stanleyville from the SARA/SARB Collection. Genome Announc. 2017;5: pubmed publisher
    ..we report the complete genome and methylome sequences of three Salmonella enterica strains from the SARA and SARB collection: S. enterica subsp. enterica serovar Typhimurium (SARA13), S...
  56. Sun J, Yu S, Zhang X, Capac C, Aligbe O, Daudelin T, et al. A Wntless-SEC12 complex on the ER membrane regulates early Wnt secretory vesicle assembly and mature ligand export. J Cell Sci. 2017;130:2159-2171 pubmed publisher
    ..also known as PREB), an ER membrane-localized guanine nucleotide-exchange factor (GEF) activator of the SAR1 (the SAR1A isoform) small GTPase...
  57. Baroja M, Herfst C, Kasper K, Xu S, Gillett D, Li J, et al. The SaeRS Two-Component System Is a Direct and Dominant Transcriptional Activator of Toxic Shock Syndrome Toxin 1 in Staphylococcus aureus. J Bacteriol. 2016;198:2732-42 pubmed publisher
    ..Although the stand-alone SarA transcriptional regulator has been shown to be both a positive and a negative regulator of TSST-1, deletion of sarA ..
  58. Perdomo Rebollo F, Kleinert Altamirano A. [Application of BARS scale in children with ataxia in a child rehabilitation center in Chiapas, Mexico]. Rev Med Inst Mex Seguro Soc. 2017;55:715-719 pubmed
    ..Scales are used to understand better its natural history and evaluate properly drug efficacy in clinical trials. SARA and ICARS scales have been the most studied and validated so far...
  59. Gao X, Oba M. Short communication: Noninvasive indicators to identify lactating dairy cows with a greater risk of subacute rumen acidosis. J Dairy Sci. 2015;98:5735-9 pubmed publisher
    ..be used as the noninvasive indicator to identify cows with greater or lower risk of subacute ruminal acidosis (SARA)...
  60. Abecia J, Chemineau P, Gomez A, Keller M, Forcada F, Delgadillo J. Presence of photoperiod-melatonin-induced, sexually-activated rams in spring advances puberty in autumn-born ewe lambs. Anim Reprod Sci. 2016;170:114-20 pubmed publisher
    ..days (16h light/d) and given three melatonin implants at the end of the long days (sexually-activated-rams; SAR): SAR1 (n=5; 1 December-31 January), SAR2 (n=5; 1 Jan-28 February), and SAR3 (n=5; 1 February-31 March)...
  61. Macmillan K, Gao X, Oba M. Increased feeding frequency increased milk fat yield and may reduce the severity of subacute ruminal acidosis in higher-risk cows. J Dairy Sci. 2017;100:1045-1054 pubmed publisher
    ..determine whether feeding behavior is different between cows at higher or lower risk for subacute ruminal acidosis (SARA) and whether increasing feeding frequency could be used to reduce the severity of SARA in higher-risk cows...
  62. Almaguer Mederos L, Almaguer Gotay D, Aguilera Rodríguez R, González Zaldivar Y, Cuello Almarales D, Laffita Mesa J, et al. Association of glutathione S-transferase omega polymorphism and spinocerebellar ataxia type 2. J Neurol Sci. 2017;372:324-328 pubmed publisher
    ..Age at onset, 60° Maximal Saccade Velocity and SARA score were used as clinical markers. GSTO1 rs4925 and GSTO2 rs2297235 SNPs were determined by PCR/RFLP...
  63. Oh hashi K, Soga A, Naruse Y, Takahashi K, Kiuchi K, Hirata Y. Elucidating post-translational regulation of mouse CREB3 in Neuro2a cells. Mol Cell Biochem. 2018;448:287-297 pubmed publisher
    ..cells by treatment with stimuli and co-transfection with genes associated with ER-Golgi homeostasis, such as mutant Sar1 [H79G], GRP78, and KDEL receptor 1 (KDELR1)...
  64. Arias C, Siri S, Conde C. Involvement of SARA in Axon and Dendrite Growth. PLoS ONE. 2015;10:e0138792 pubmed publisher
    b>SARA (Smad Anchor for Receptor Activation) plays a crucial role in Rab5-mediated endocytosis in cell lines localizing to early endosomes where it regulates morphology and function...
  65. Yu W, Du Y, Zou Y, Wang X, Stephani U, Lü Y. Smad anchor for receptor activation contributes to seizures in temporal lobe epilepsy. Synapse. 2017;71: pubmed publisher
    Smad anchor for receptor activation (SARA) is an important regulator of transforming growth factor β (TGF-β) signaling by recruiting Smad2/3 to TGF-β receptors...
  66. Mendonça P, Matos A, Sousa A, Serra A, Simões S, Coelho J. Increasing the Bile Acid Sequestration Performance of Cationic Hydrogels by Using an Advanced/Controlled Polymerization Technique. Pharm Res. 2017;34:1934-1943 pubmed publisher
    ..In addition, it was demonstrated for the first time that the hydrogels produced by SARA ATRP presented a higher binding capacity than similar ones produced by FRP...
  67. Neubauer V, Humer E, Kröger I, Meißl A, Reisinger N, Zebeli Q. Technical note: Changes in rumen mucosa thickness measured by transabdominal ultrasound as a noninvasive method to diagnose subacute rumen acidosis in dairy cows. J Dairy Sci. 2018;101:2650-2654 pubmed publisher
    ..The subsequent prolonged decline in ruminal pH can lead to subacute ruminal acidosis (SARA)...
  68. Zhu J, Chin K, Aerbajinai W, Kumkhaek C, Li H, Rodgers G. Hydroxyurea-inducible SAR1 gene acts through the Gi?/JNK/Jun pathway to regulate ?-globin expression. Blood. 2014;124:1146-56 pubmed publisher
    ..We previously reported that overexpression of the HU-induced SAR1 gene closely mimics the known effects of HU on K562 and CD34(+) cells, including ?-globin induction and cell-cycle ..
  69. Pule G, Bitoungui V, Chemegni B, Kengne A, Wonkam A. SAR1a promoter polymorphisms are not associated with fetal hemoglobin in patients with sickle cell disease from Cameroon. BMC Res Notes. 2017;10:183 pubmed publisher
    ..variants in the HU-inducible small guanosine triphosphate-binding protein, secretion-associated and RAS-related (SAR1a) protein, previously shown to be associated with HbF after HU treatment in African American SCD patients...
  70. Iwasaki H, Yorimitsu T, Sato K. Microscopy analysis of reconstituted COPII coat polymerization and Sec16 dynamics. J Cell Sci. 2017;130:2893-2902 pubmed publisher
    The COPII coat and the small GTPase Sar1 mediate protein export from the endoplasmic reticulum (ER) via specialized domains known as the ER exit sites. The peripheral ER protein Sec16 has been proposed to organize ER exit sites...
  71. Elles Pérez C, Muñoz Acevedo A, Guzmán A, Camargo H, Henao J. Evaluation of heavy crude oil from a water-oil model system as starting material for the preparation of adsorbents type NaY zeolite-templated carbon. J Environ Manage. 2017;196:466-475 pubmed publisher
    ..composite and porous carbons were characterized using structural/surface analysis techniques (API Gravity, SARA, IR, XRD, XRF, TGA, Langmuir isotherms, BET and SEM)...
  72. Yan X, Gu S, Shi Y, Cui X, Wen S, Ge J. The effect of emodin on Staphylococcus aureus strains in planktonic form and biofilm formation in vitro. Arch Microbiol. 2017;199:1267-1275 pubmed publisher
    ..of extracellular DNA and inhibited expression of the biofilm-related genes (cidA, icaA, dltB, agrA, sortaseA and sarA) by real-time RT-PCR...
  73. Fryer L, Jones B, Duncan E, Hutchison C, Ozkan T, Williams P, et al. The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis. J Biol Chem. 2014;289:4244-61 pubmed publisher
    ..We also show that although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes ..
  74. Kim S, Reyes D, Beaume M, Francois P, Cheung A. Contribution of teg49 small RNA in the 5' upstream transcriptional region of sarA to virulence in Staphylococcus aureus. Infect Immun. 2014;82:4369-79 pubmed publisher
    High-throughput RNA sequencing technology has found the 5' untranslated region of sarA to contain two putative small RNAs (sRNAs), designated teg49 and teg48...
  75. Salcı Y, Fil A, Keklicek H, Çetin B, Armutlu K, Dolgun A, et al. Validity and reliability of the International Cooperative Ataxia Rating Scale (ICARS) and the Scale for the Assessment and Rating of Ataxia (SARA) in multiple sclerosis patients with ataxia. Mult Scler Relat Disord. 2017;18:135-140 pubmed publisher
    ..of the International Cooperative Ataxia Rating Scale (ICARS) and Scale for the Assessment and Rating of Ataxia (SARA), which are widely used in ataxia evaluation in the context of other cerebellar diseases...
  76. Watson P, Forster R, Palmer K, Pepperkok R, Stephens D. Coupling of ER exit to microtubules through direct interaction of COPII with dynactin. Nat Cell Biol. 2005;7:48-55 pubmed
    ..Together, our data suggest a mechanism by which membranes of the early secretory pathway can be linked to motors and microtubules for subsequent organization and movement to the Golgi apparatus...
  77. Schindler A, Schekman R. In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles. Proc Natl Acad Sci U S A. 2009;106:17775-80 pubmed publisher
    ..These results suggest that unfolded proteins or an ER luminal -SH reactive bond controls BiP-ATF6 stability and access of ATF6 to the COPII budding machinery. ..
  78. Barozzi F, Di Sansebastiano G, Sabella E, Aprile A, Piro G, De Bellis L, et al. Glutathione S-transferase related detoxification processes are correlated with receptor-mediated vacuolar sorting mechanisms. Plant Cell Rep. 2017;36:1361-1373 pubmed publisher
    ..experiments in Nicotiana tabacum protoplasts using two vacuolar markers, AleuGFPgl133 and GFPgl133Chi, labeling the Sar1 dependent or independent sorting, respectively...
  79. Lawerman T, Brandsma R, Burger H, Burgerhof J, Sival D. Age-related reference values for the pediatric Scale for Assessment and Rating of Ataxia: a multicentre study. Dev Med Child Neurol. 2017;59:1077-1082 pubmed publisher
    For reliable assessment of ataxia severity in children, the Childhood Ataxia and Cerebellar Group of the European Pediatric Neurology Society aimed to validate the Scale for Assessment and Rating of Ataxia (SARA) according to age.
  80. Johren O, Saavedra J. Expression of AT1A and AT1B angiotensin II receptor messenger RNA in forebrain of 2-wk-old rats. Am J Physiol. 1996;271:E104-12 pubmed
    ..was localized in the forebrain of 2-wk-old rats by in situ hybridization histochemistry and compared with [125I]Sar1-angiotensin II binding patterns...
  81. Mancias J, Goldberg J. Structural basis of cargo membrane protein discrimination by the human COPII coat machinery. EMBO J. 2008;27:2918-28 pubmed publisher
  82. Zhuang X, Chowdhury S, Northup J, Ray K. Sar1-dependent trafficking of the human calcium receptor to the cell surface. Biochem Biophys Res Commun. 2010;396:874-80 pubmed publisher
    ..We investigated the role of the Sar1 small GTP-binding protein in cell surface transport of the hCaR...
  83. Riggs B, Bergman Z, Heald R. Altering membrane topology with Sar1 does not impair spindle assembly in Xenopus egg extracts. Cytoskeleton (Hoboken). 2012;69:591-9 pubmed publisher
    ..The GTPase Sar1 is a component of the secretory pathway and a key activator of anterograde transport of cargo from the ER to the ..
  84. Yonemura Y, Li X, Müller K, Kramer A, Atigbire P, Mentrup T, et al. Inhibition of cargo export at ER exit sites and the trans-Golgi network by the secretion inhibitor FLI-06. J Cell Sci. 2016;129:3868-3877 pubmed
    Export out of the endoplasmic reticulum (ER) involves the Sar1 and COPII machinery acting at ER exit sites (ERES). Whether and how cargo proteins are recruited upstream of Sar1 and COPII is unclear...
  85. Huang S, Wu Y, Jao C, Soong B, Lirng J, Wu H, et al. CAG repeat length does not associate with the rate of cerebellar degeneration in spinocerebellar ataxia type 3. Neuroimage Clin. 2017;13:97-105 pubmed
    ..We measured each patient's Scale for the Assessment and Rating of Ataxia (SARA) score, N-acetylaspartate (NAA)/creatine (Cr) ratios based on magnetic resonance spectroscopy (MRS), and 3-..
  86. Cook M, Cazin C, Amoyel M, Yamamoto S, Bach E, Nystul T. Neutral Competition for Drosophila Follicle and Cyst Stem Cell Niches Requires Vesicle Trafficking Genes. Genetics. 2017;206:1417-1428 pubmed publisher
    ..We also show that Sec16 and another COPII vesicle trafficking component, Sar1, are required for follicle cell differentiation...
  87. Ito Y, Uemura T, Nakano A. The Golgi entry core compartment functions as a COPII-independent scaffold for ER-to-Golgi transport in plant cells. J Cell Sci. 2018;131: pubmed publisher
    ..Expression of a dominant mutant form of SAR1 does not affect the formation of the punctate structures...
  88. South S, Sacksteder K, Li X, Liu Y, Gould S. Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis. J Cell Biol. 2000;149:1345-60 pubmed
    ..We also find that inhibition of COPII-dependent membrane traffic by a dominant negative SAR1 mutant fails to block PEX3 transport to peroxisomes and PEX3-mediated peroxisome synthesis...
  89. Kurokawa K, Suda Y, Nakano A. Sar1 localizes at the rims of COPII-coated membranes in vivo. J Cell Sci. 2016;129:3231-7 pubmed publisher
    The Sar1 GTPase controls coat assembly on coat protein complex II (COPII)-coated vesicles, which mediate protein transport from the endoplasmic reticulum (ER) to the Golgi...
  90. Gorur A, Yuan L, Kenny S, Baba S, Xu K, Schekman R. COPII-coated membranes function as transport carriers of intracellular procollagen I. J Cell Biol. 2017;216:1745-1759 pubmed publisher
    ..This process requires COPII proteins and the GTPase activity of the COPII subunit SAR1. We conclude that large COPII vesicles are bona fide carriers of PC1.
  91. Manna A, Kim S, Cengher L, Corvaglia A, Léo S, Francois P, et al. Small RNA teg49 Is Derived from a sarA Transcript and Regulates Virulence Genes Independent of SarA in Staphylococcus aureus. Infect Immun. 2018;86: pubmed publisher
    ..The sarA locus consists of three overlapping transcripts generated from three distinct promoters, all containing the ..
  92. Stefanska B, Pruszyńska Oszmałek E, Szczepankiewicz D, Stajek K, Stefanski P, Gehrke M, et al. Relationship between pH of ruminal fluid during subacute ruminal acidosis and physiological response of the Polish Holstein-Friesian dairy cows. Pol J Vet Sci. 2017;20:551-558 pubmed publisher
    ..and milk, and to determine which of them may be helpful as a marker for the diagnosis of subacute ruminal acidosis (SARA). Ruminal fluid samples were obtained by rumenocentesis from 305 cows representing 13 commercial dairy herds...