SAP30L

Summary

Gene Symbol: SAP30L
Description: SAP30 like
Alias: NS4ATP2, histone deacetylase complex subunit SAP30L, HCV non-structural protein 4A-transactivated protein 2, Sin3A associated protein p30-like, sin3 corepressor complex subunit SAP30L, sin3-associated protein p30-like
Species: human
Products:     SAP30L

Top Publications

  1. Lindfors K, Viiri K, Niittynen M, Heinonen T, Maki M, Kainulainen H. TGF-beta induces the expression of SAP30L, a novel nuclear protein. BMC Genomics. 2003;4:53 pubmed
    ..resulted in the identification of a novel TGF-beta upregulated mRNA species, the Sin3-associated protein 30-like, SAP30L. The mRNA is expressed in several human tissues and codes for a nuclear protein of 183 amino acids 70% identical ..
  2. Qin X, Zhu W, Lu A, Wang G, Ye X, Weng G. Long non-coding RNA SAP30L-AS1 promotes prostate cancer growth through repressing SAP30L. Gene. 2019;690:120-128 pubmed publisher
    ..LncRNA SAP30L-AS1 is previously identified in the plasma of prostate cancer patients...
  3. Wang Y, Ji J, Wang B, Chen H, Yang Z, Wang K, et al. Tumor-Derived Exosomal Long Noncoding RNAs as Promising Diagnostic Biomarkers for Prostate Cancer. Cell Physiol Biochem. 2018;46:532-545 pubmed publisher
    ..The levels of SAP30L-AS1 were upregulated in benign prostatic hyperplasia (BPH), and SChLAP1 levels were significantly higher in PCa ..
  4. Banks C, Thornton J, Eubanks C, Adams M, Miah S, Boanca G, et al. A Structured Workflow for Mapping Human Sin3 Histone Deacetylase Complex Interactions Using Halo-MudPIT Affinity-Purification Mass Spectrometry. Mol Cell Proteomics. 2018;17:1432-1447 pubmed publisher
    ..we apply the workflow to map interactions between stably expressed versions of the Sin3 subunits SUDS3, SAP30, or SAP30L and other cellular proteins...
  5. Assmann E, Alborghetti M, Camargo M, Kobarg J. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. J Biol Chem. 2006;281:9869-81 pubmed
    ..The confirmed interacting proteins include FEZ1 itself and three transcription controlling proteins (SAP30L, DRAP1, and BAF60a)...
  6. Viiri K, Korkeamäki H, Kukkonen M, Nieminen L, Lindfors K, Peterson P, et al. SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. Nucleic Acids Res. 2006;34:3288-98 pubmed
    ..Here, we report that SAP30L, a close homolog of Sin3-associated protein 30 (SAP30), interacts with several components of the Sin3A corepressor ..
  7. Korkeamäki H, Viiri K, Kukkonen M, Maki M, Lohi O. Alternative mRNA splicing of SAP30L regulates its transcriptional repression activity. FEBS Lett. 2008;582:379-84 pubmed
    ..In this study we characterized three novel transcripts of SAP30L, a recently identified Sin3A-associated protein...
  8. Hong K, Lim J, Kim J, Tabara Y, Ueshima H, Miki T, et al. Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. Hum Mol Genet. 2014;23:6659-67 pubmed publisher
    ..In addition, C allele of rs17026156 increases PR interval (beta ± SE, 2.39 ± 0.40 ms) and exists far more frequently in East Asians (0.46) than in Europeans and Africans (0.05 and 0.08, respectively). ..
  9. Boultwood J, Fidler C, Strickson A, Watkins F, Kostrzewa M, Jaju R, et al. Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. Genomics. 2000;66:26-34 pubmed
    ..Genomic localization and expression patterns would suggest that the 8 novel cDNAs described in this report represent potential candidate genes for the 5q- syndrome. ..

More Information

Publications11

  1. Viiri K, Jänis J, Siggers T, Heinonen T, Valjakka J, Bulyk M, et al. DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. Mol Cell Biol. 2009;29:342-56 pubmed publisher
    ..Two proteins in this complex, the Sin3A-associated proteins SAP30L and SAP30, have previously been suggested to function as linker molecules between various corepressors...
  2. Laitaoja M, Tossavainen H, Pihlajamaa T, Valjakka J, Viiri K, Lohi O, et al. Redox-dependent disulfide bond formation in SAP30L corepressor protein: Implications for structure and function. Protein Sci. 2016;25:572-86 pubmed publisher
    Sin3A-associated protein 30-like (SAP30L) is one of the key proteins in a multi-subunit protein complex involved in transcriptional regulation via histone deacetylation...