SAMHD1

Summary

Gene Symbol: SAMHD1
Description: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Alias: CHBL2, DCIP, HDDC1, MOP-5, SBBI88, deoxynucleoside triphosphate triphosphohydrolase SAMHD1, SAM domain and HD domain 1, SAM domain and HD domain-containing protein 1, dNTPase, dendritic cell-derived IFNG-induced protein, monocyte protein 5
Species: human
Products:     SAMHD1

Top Publications

  1. Rice G, Bond J, Asipu A, Brunette R, Manfield I, Carr I, et al. Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response. Nat Genet. 2009;41:829-32 pubmed publisher
    ..Here we describe mutations in SAMHD1 as the cause of AGS at the AGS5 locus and present data to show that SAMHD1 may act as a negative regulator of the ..
  2. Riveira Munoz E, Ruiz A, Pauls E, Permanyer M, Badia R, Mothe B, et al. Increased expression of SAMHD1 in a subset of HIV-1 elite controllers. J Antimicrob Chemother. 2014;69:3057-60 pubmed publisher
    b>SAMHD1 and the CDKN1A (p21) cyclin-dependent kinase inhibitor have been postulated to mediate HIV-1 restriction in CD4+ cells. We have shown that p21 affects HIV replication through its effect on SAMHD1...
  3. Thiele H, du Moulin M, Barczyk K, George C, Schwindt W, Nurnberg G, et al. Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression. Hum Mutat. 2010;31:E1836-50 pubmed publisher
    ..Next generation sequencing of the entire region identified the c.490C>T (p.Arg164X) mutationin SAMHD1, a gene most recently described in AGS, on both alleles in all affected siblings...
  4. Coon S, Wang D, Wu L. Polymorphisms of the SAMHD1 gene are not associated with the infection and natural control of HIV type 1 in Europeans and African-Americans. AIDS Res Hum Retroviruses. 2012;28:1565-73 pubmed publisher
    The HIV-1 restriction factor SAM domain and HD domain-containing protein 1 (SAMHD1) blocks HIV-1 infection in human myeloid cells. Mutations in the SAMHD1 gene are associated with rare genetic diseases including Aicardi-Goutieres syndrome...
  5. Brandariz Nuñez A, Valle Casuso J, White T, Laguette N, Benkirane M, BROJATSCH J, et al. Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac. Retrovirology. 2012;9:49 pubmed publisher
    b>SAMHD1 is a nuclear protein that blocks lentiviral infection before reverse transcription in macrophages and dendritic cells...
  6. Beloglazova N, Flick R, Tchigvintsev A, Brown G, Popović A, Nocek B, et al. Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction. J Biol Chem. 2013;288:8101-10 pubmed publisher
    The human HD domain protein SAMHD1 is implicated in the Aicardi-Goutières autoimmune syndrome and in the restriction of HIV-1 replication in myeloid cells...
  7. Goncalves A, Karayel E, Rice G, Bennett K, Crow Y, Superti Furga G, et al. SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations. Hum Mutat. 2012;33:1116-22 pubmed publisher
    ..three prime repair exonuclease 1 (TREX1); and sterile alpha motif (SAM) domain and HD domain-containing protein 1 (SAMHD1)...
  8. Zhu C, Gao W, Zhao K, Qin X, Zhang Y, Peng X, et al. Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase. Nat Commun. 2013;4:2722 pubmed publisher
    SAMHD1 is a dGTP-activated deoxynucleoside triphosphate triphosphohydrolase (dNTPase) whose dNTPase activity has been linked to HIV/SIV restriction. The mechanism of its dGTP-activated dNTPase function remains unclear...
  9. Welbourn S, Dutta S, Semmes O, Strebel K. Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1. J Virol. 2013;87:11516-24 pubmed publisher
    ..It has been proposed that SAMHD1 is a dGTP-dependent deoxynucleoside triphosphohydrolase (dNTPase) that restricts HIV-1 by reducing cellular dNTP levels to below that required for reverse transcription...

More Information

Publications72

  1. Franzolin E, Pontarin G, Rampazzo C, Miazzi C, Ferraro P, Palumbo E, et al. The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells. Proc Natl Acad Sci U S A. 2013;110:14272-7 pubmed publisher
    Sterile alpha motif and HD-domain containing protein 1 (SAMHD1) is a triphosphohydrolase converting deoxynucleoside triphosphates (dNTPs) to deoxynucleosides...
  2. Tabler C, Lucera M, Haqqani A, MCDONALD D, Migueles S, Connors M, et al. CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression. J Virol. 2014;88:4976-86 pubmed publisher
    ..Knockdown of the HIV restriction factor SAMHD1 using Vpx-containing simian immunodeficiency virus (SIV) virion-like particles enhanced the productive infection ..
  3. Ahn J, Hao C, Yan J, Delucia M, Mehrens J, Wang C, et al. HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1. J Biol Chem. 2012;287:12550-8 pubmed publisher
    The sterile alpha motif and HD domain-containing protein-1 (SAMHD1) inhibits infection of myeloid cells by human and related primate immunodeficiency viruses (HIV and SIV)...
  4. Lahouassa H, Daddacha W, Hofmann H, Ayinde D, Logue E, Dragin L, et al. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat Immunol. 2012;13:223-228 pubmed publisher
    b>SAMHD1 restricts the infection of dendritic and other myeloid cells by human immunodeficiency virus type 1 (HIV-1), but in lentiviruses of the simian immunodeficiency virus of sooty mangabey (SIVsm)-HIV-2 lineage, SAMHD1 is counteracted ..
  5. Puigdomènech I, Casartelli N, Porrot F, Schwartz O. SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells. J Virol. 2013;87:2846-56 pubmed publisher
    b>SAMHD1 is a viral restriction factor expressed in dendritic cells and other cells, inhibiting infection by cell-free human immunodeficiency virus type 1 (HIV-1) particles...
  6. Berger A, Sommer A, Zwarg J, Hamdorf M, Welzel K, Esly N, et al. SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection. PLoS Pathog. 2011;7:e1002425 pubmed publisher
    ..that Vpx from HIV-2/SIVsm facilitates infection of these cells by counteracting the host restriction factor SAMHD1. Here, we independently confirmed that Vpx interacts with SAMHD1 and targets it for ubiquitin-mediated degradation...
  7. Berger G, Turpin J, Cordeil S, Tartour K, Nguyen X, Mahieux R, et al. Functional analysis of the relationship between Vpx and the restriction factor SAMHD1. J Biol Chem. 2012;287:41210-7 pubmed publisher
    b>SAMHD1 is a newly identified restriction factor that targets lentiviruses in myeloid cells and is countered by the SIV(SM)/HIV-2 Vpx protein...
  8. Dale R, Gornall H, Singh Grewal D, Alcausin M, Rice G, Crow Y. Familial Aicardi-Goutières syndrome due to SAMHD1 mutations is associated with chronic arthropathy and contractures. Am J Med Genet A. 2010;152A:938-42 pubmed publisher
    We report on two siblings doubly heterozygous for null mutations in the recently identified AGS5 gene SAMHD1. The older female child showed mild intellectual disability with microcephaly...
  9. Baldauf H, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, et al. SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells. Nat Med. 2012;18:1682-7 pubmed publisher
    ..Here we show that the deoxynucleoside triphosphate triphosphohydrolase SAMHD1 prevents reverse transcription of HIV-1 RNA in resting CD4(+) T cells...
  10. White T, Brandariz Nuñez A, Valle Casuso J, Amie S, Nguyen L, Kim B, et al. Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1. Virology. 2013;436:81-90 pubmed publisher
    The human SAMHD1 protein is a novel retroviral restriction factor expressed in myeloid cells. Previous work has correlated the deoxynucleotide triphosphohydrolase activity of SAMHD1 with its ability to block HIV-1 and SIV(mac) infection...
  11. Cribier A, Descours B, Valadão A, Laguette N, Benkirane M. Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1. Cell Rep. 2013;3:1036-43 pubmed publisher
    b>SAMHD1 restricts HIV-1 replication in myeloid and quiescent CD4(+) T cells. Here, we show that SAMHD1 restriction activity is regulated by phosphorylation. SAMHD1 interacts with cyclin A2/cdk1 only in cycling cells...
  12. Schwefel D, Groom H, Boucherit V, Christodoulou E, Walker P, Stoye J, et al. Structural basis of lentiviral subversion of a cellular protein degradation pathway. Nature. 2014;505:234-8 pubmed publisher
    ..One such restriction factor, SAMHD1, inhibits human immunodeficiency virus (HIV)-1 infection of myeloid-lineage cells as well as resting CD4(+) T ..
  13. Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable Bessia C, Segeral E, et al. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature. 2011;474:654-7 pubmed publisher
    ..Here we identify SAMHD1 as this restriction factor...
  14. Li N, Zhang W, Cao X. Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells. Immunol Lett. 2000;74:221-4 pubmed
  15. Delucia M, Mehrens J, Wu Y, Ahn J. HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation. J Biol Chem. 2013;288:19116-26 pubmed publisher
    b>SAMHD1, a dGTP-regulated deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase, down-regulates dNTP pools in terminally differentiated and quiescent cells, thereby inhibiting HIV-1 infection at the reverse transcription step...
  16. Yan J, Kaur S, Delucia M, Hao C, Mehrens J, Wang C, et al. Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem. 2013;288:10406-17 pubmed publisher
    SAMHD1 is a dGTP-activated dNTPase that has been implicated as a modulator of the innate immune response...
  17. Xin B, Jones S, Puffenberger E, Hinze C, Bright A, Tan H, et al. Homozygous mutation in SAMHD1 gene causes cerebral vasculopathy and early onset stroke. Proc Natl Acad Sci U S A. 2011;108:5372-7 pubmed publisher
    ..22-q12. Candidate gene sequencing identified a homozygous mutation, c.1411-2A > G, in the SAMHD1 gene, being associated with this condition...
  18. Gramberg T, Kahle T, Bloch N, Wittmann S, Müllers E, Daddacha W, et al. Restriction of diverse retroviruses by SAMHD1. Retrovirology. 2013;10:26 pubmed publisher
    b>SAMHD1 is a triphosphohydrolase that restricts the replication of HIV-1 and SIV in myeloid cells...
  19. Liao W, Bao Z, Cheng C, Mok Y, Wong W. Dendritic cell-derived interferon-gamma-induced protein mediates tumor necrosis factor-alpha stimulation of human lung fibroblasts. Proteomics. 2008;8:2640-50 pubmed publisher
    ..In particular, dendritic cell-derived interferon-gamma-induced protein (DCIP) was upregulated by TNF-alpha in lung fibroblasts and its biological function is at present unknown...
  20. Goldstone D, Ennis Adeniran V, Hedden J, Groom H, Rice G, Christodoulou E, et al. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature. 2011;480:379-82 pubmed publisher
    b>SAMHD1, an analogue of the murine interferon (IFN)-?-induced gene Mg11 (ref...
  21. Harris R, Hultquist J, Evans D. The restriction factors of human immunodeficiency virus. J Biol Chem. 2012;287:40875-83 pubmed publisher
    ..and how the viral Vpx protein prevents the premature termination of reverse transcription by degrading the dNTPase SAMHD1...
  22. Hrecka K, Hao C, Gierszewska M, Swanson S, Kesik Brodacka M, Srivastava S, et al. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature. 2011;474:658-61 pubmed publisher
    ..the inhibition of HIV-1 infection in macrophages involves the cellular SAM domain HD domain-containing protein 1 (SAMHD1)...
  23. Kim E, White T, Brandariz Nuñez A, Diaz Griffero F, Weitzman M. SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication. J Virol. 2013;87:12949-56 pubmed publisher
    ..b>SAMHD1 was recently identified as a retrovirus restriction factor highly expressed in macrophages...
  24. Hollenbaugh J, Gee P, Baker J, Daly M, Amie S, Tate J, et al. Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells. PLoS Pathog. 2013;9:e1003481 pubmed publisher
    b>SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells...
  25. Ryoo J, Choi J, Oh C, Kim S, Seo M, Kim S, et al. The ribonuclease activity of SAMHD1 is required for HIV-1 restriction. Nat Med. 2014;20:936-41 pubmed publisher
    ..ability to restrict HIV-1 without decreasing cellular dNTP levels, which is not consistent with a role for SAMHD1 dNTPase activity in HIV-1 restriction...
  26. Descours B, Cribier A, Chable Bessia C, Ayinde D, Rice G, Crow Y, et al. SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells. Retrovirology. 2012;9:87 pubmed publisher
    ..Examination of SAMHD1 expression in peripheral blood lymphocytes shows that SAMHD1 is expressed in both CD4+ and CD8+ T cells at levels ..
  27. Hofmann H, Logue E, Bloch N, Daddacha W, Polsky S, Schultz M, et al. The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus. J Virol. 2012;86:12552-60 pubmed publisher
    Sterile alpha motif domain- and HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase that restricts the replication of lentiviruses in myeloid cells by hydrolyzing the cellular deoxynucleotide triphosphates to ..
  28. White T, Brandariz Nuñez A, Valle Casuso J, Amie S, Nguyen L, Kim B, et al. The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation. Cell Host Microbe. 2013;13:441-51 pubmed publisher
    b>SAMHD1 is a cellular enzyme that depletes intracellular deoxynucleoside triphosphates (dNTPs) and inhibits the ability of retroviruses, notably HIV-1, to infect myeloid cells...
  29. Kim B, Nguyen L, Daddacha W, Hollenbaugh J. Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages. J Biol Chem. 2012;287:21570-4 pubmed publisher
    Recently, SAMHD1 has come under intense focus as a host anti-HIV factor. SAMHD1 is a dNTP triphosphohydrolase, which leads to the regulation of DNA metabolism in host cells...
  30. Rehwinkel J, Maelfait J, Bridgeman A, Rigby R, Hayward B, Liberatore R, et al. SAMHD1-dependent retroviral control and escape in mice. EMBO J. 2013;32:2454-62 pubmed publisher
    b>SAMHD1 is a host restriction factor for human immunodeficiency virus 1 (HIV-1) in cultured human cells. SAMHD1 mutations cause autoimmune Aicardi-Goutières syndrome and are found in cancers including chronic lymphocytic leukaemia...
  31. Pauls E, Jiménez E, Ruiz A, Permanyer M, Ballana E, Costa H, et al. Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1. J Immunol. 2013;190:4736-41 pubmed publisher
    ..The HIV-1 restriction factor sterile ? motif and HD domain-containing protein-1 (SAMHD1) was significantly overexpressed in IL-12/IL-18 MDM compared with M-CSF MDM, and degradation of SAMHD1 by RNA ..
  32. Wei W, Guo H, Han X, Liu X, Zhou X, Zhang W, et al. A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest. Cell Microbiol. 2012;14:1745-56 pubmed publisher
    ..motif in SIVmac Vpx is required for both the Vpx-DCAF1 interaction and/or Vpx-mediated degradation of SAMHD1. DCAF1-binding defective Vpx mutants also have impaired ability to promote SIV?Vpx virus infection of myeloid ..
  33. Ji X, Wu Y, Yan J, Mehrens J, Yang H, Delucia M, et al. Mechanism of allosteric activation of SAMHD1 by dGTP. Nat Struct Mol Biol. 2013;20:1304-9 pubmed publisher
    SAMHD1, a dNTP triphosphohydrolase (dNTPase), has a key role in human innate immunity...
  34. St Gelais C, de Silva S, Amie S, Coleman C, Hoy H, Hollenbaugh J, et al. SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons. Retrovirology. 2012;9:105 pubmed publisher
    b>SAMHD1 is an HIV-1 restriction factor in non-dividing monocytes, dendritic cells (DCs), macrophages, and resting CD4+ T-cells...
  35. Ayinde D, Casartelli N, Schwartz O. Restricting HIV the SAMHD1 way: through nucleotide starvation. Nat Rev Microbiol. 2012;10:675-80 pubmed publisher
    ..b>SAMHD1 was recently identified as a novel HIV restriction factor in myeloid cells, and was shown to be blocked by the ..
  36. Amie S, Bambara R, Kim B. GTP is the primary activator of the anti-HIV restriction factor SAMHD1. J Biol Chem. 2013;288:25001-6 pubmed publisher
    b>SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates...
  37. Powell R, Holland P, Hollis T, Perrino F. Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase. J Biol Chem. 2011;286:43596-600 pubmed publisher
    The SAMHD1 protein is an HIV-1 restriction factor that is targeted by the HIV-2 accessory protein Vpx in myeloid lineage cells...
  38. Welbourn S, Miyagi E, White T, Diaz Griffero F, Strebel K. Identification and characterization of naturally occurring splice variants of SAMHD1. Retrovirology. 2012;9:86 pubmed publisher
    ..SAMHD1 is a dNTPase that presumably reduces the cellular dNTP levels to levels too low for retroviral reverse transcription to occur...
  39. St Gelais C, Wu L. SAMHD1: a new insight into HIV-1 restriction in myeloid cells. Retrovirology. 2011;8:55 pubmed publisher
    ..Two recent studies discovered the cellular protein SAMHD1 to be this restriction factor, demonstrating that Vpx induces proteasomal degradation of SAMHD1 and enhances HIV-1 ..
  40. Guo H, Wei W, Wei Z, Liu X, Evans S, Yang W, et al. Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation. PLoS ONE. 2013;8:e66201 pubmed publisher
    The sterile alpha motif (SAM) and HD domain-containing protein-1 (SAMHD1) inhibits the infection of resting CD4+ T cells and myeloid cells by human and related simian immunodeficiency viruses (HIV and SIV)...
  41. Fregoso O, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M. Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1. PLoS Pathog. 2013;9:e1003496 pubmed publisher
    b>SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells...
  42. Zhao K, Du J, Han X, Goodier J, Li P, Zhou X, et al. Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1. Cell Rep. 2013;4:1108-15 pubmed publisher
    ..Here, we demonstrate that the Aicardi-Goutières syndrome gene product SAMHD1, recently revealed to be an inhibitor of HIV/simian immunodeficiency virus (SIV) infectivity and neutralized by ..
  43. Tüngler V, Staroske W, Kind B, Dobrick M, Kretschmer S, Schmidt F, et al. Single-stranded nucleic acids promote SAMHD1 complex formation. J Mol Med (Berl). 2013;91:759-70 pubmed publisher
    SAM domain and HD domain-containing protein 1 (SAMHD1) is a dGTP-dependent triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs) thereby limiting the intracellular dNTP pool...
  44. Oh C, Ryoo J, Park K, Kim B, Daly M, Cho D, et al. A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature. Sci Rep. 2018;8:84 pubmed publisher
    ..SAMHD1 possesses both dNTPase and RNase activities and mutations in SAMHD1 cause AGS; however, how SAMHD1-deficiency causes the type I ..
  45. Bermejo M, López Huertas M, García Pérez J, Climent N, Descours B, Ambrosioni J, et al. Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells. Biochem Pharmacol. 2016;106:30-45 pubmed publisher
    ..During T-cell activation, the antiviral effect of the innate factor SAMHD1 is neutralized through phosphorylation at T592, allowing HIV-1 infection...
  46. Johansson P, Klein Hitpass L, Choidas A, Habenberger P, Mahboubi B, Kim B, et al. SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia. Blood Cancer J. 2018;8:11 pubmed publisher
    ..We identified recurrently mutated genes previously unknown to be mutated in T-PLL, which are SAMHD1, HERC1, HERC2, PRDM2, PARP10, PTPRC, and FOXP1...
  47. Li W, Gorantla S, Gendelman H, Poluektova L. Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains. Dis Model Mech. 2017;10:1489-1502 pubmed publisher
    ..i>IFI6) and a range of host antiviral responses (MX1, OAS1, RSAD2, BST2, SAMHD1) were observed...
  48. Cabello Lobato M, Wang S, Schmidt C. SAMHD1 Sheds Moonlight on DNA Double-Strand Break Repair. Trends Genet. 2017;33:895-897 pubmed publisher
    b>SAMHD1 (sterile ? motif and histidine (H) aspartate (D) domain-containing protein 1) is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al...
  49. Wills Q, Mellado Gomez E, Nolan R, Warner D, Sharma E, Broxholme J, et al. The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq. BMC Genomics. 2017;18:53 pubmed publisher
    ..Using gene-edited macrophages we demonstrate how previously unappreciated knockout effects of SAMHD1, such as an altered oxidative stress response, have a large paracrine signaling component...
  50. Buchanan E, Espinoza D, McAlexander M, Myers S, Moyer A, Witwer K. SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load. Sci Rep. 2016;6:22629 pubmed publisher
    ..cells is attributed in part to the nucleotidase activity of the SAM-domain and HD-domain containing protein (SAMHD1), which depletes free nucleotides, blocking reverse transcription...
  51. Ayinde D, Bruel T, Cardinaud S, Porrot F, Prado J, Moris A, et al. SAMHD1 Limits HIV-1 Antigen Presentation by Monocyte-Derived Dendritic Cells. J Virol. 2015;89:6994-7006 pubmed
    ..MDDC are poorly susceptible to HIV-1, in part due to the presence of SAMHD1, a cellular enzyme that depletes intracellular deoxynucleoside triphosphates (dNTPs) and degrades viral RNA...
  52. Reinhard C, Bottinelli D, Kim B, Luban J. Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration. Retrovirology. 2014;11:12 pubmed publisher
    SIVMAC/HIV-2 Vpx recruits the CUL4A-DCAF1 E3 ubiquitin ligase complex to degrade the deoxynucleotide hydrolase SAMHD1. This increases the concentration of deoxynucleotides available for reverse transcription in myeloid cells and resting T ..
  53. Hertoghs N, Geijtenbeek T, Ribeiro C. Interplay between HIV-1 innate sensing and restriction in mucosal dendritic cells: balancing defense and viral transmission. Curr Opin Virol. 2017;22:112-119 pubmed publisher
    ..of HIV-1 at the mucosal surfaces with DC-expressed innate immune factors including cGAS, TRIM5α and SAMHD1 are predictive of viraemia, inflammation and disease pathogenesis...
  54. Mlcochova P, Caswell S, Taylor I, Towers G, Gupta R. DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages. EMBO J. 2018;37:50-62 pubmed publisher
    ..b>SAMHD1 suppresses viral reverse transcription (RT) through depletion of cellular dNTPs but is naturally switched off by ..
  55. Franzolin E, Salata C, Bianchi V, Rampazzo C. The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase. J Biol Chem. 2015;290:25986-96 pubmed publisher
    The dNTP triphosphohydrolase SAMHD1 is a nuclear antiviral host restriction factor limiting HIV-1 infection in macrophages and a major regulator of dNTP concentrations in human cells...
  56. Baldauf H, Stegmann L, Schwarz S, Ambiel I, Trotard M, Martin M, et al. Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells. Proc Natl Acad Sci U S A. 2017;114:2729-2734 pubmed publisher
    ..In this context, dNTP triphosphohydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) has been identified as a restriction factor, lowering the concentration of dNTP substrates to limit RT...
  57. White T, Brandariz Nuñez A, Martínez López A, Knowlton C, Lenzi G, Kim B, et al. A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans. Hum Mutat. 2017;38:658-668 pubmed publisher
    Mutations in the human SAMHD1 gene are known to correlate with the development of the Aicardi-Goutières syndrome (AGS), which is an inflammatory encephalopathy that exhibits neurological dysfunction characterized by increased production ..
  58. Badia R, Pujantell M, Torres Torronteras J, Menéndez Arias L, Martí R, Ruzo A, et al. SAMHD1 is active in cycling cells permissive to HIV-1 infection. Antiviral Res. 2017;142:123-135 pubmed publisher
    b>SAMHD1 is a triphosphohydrolase that restricts HIV-1 by limiting the intracellular dNTP pool required for reverse transcription...
  59. Lee E, Seo J, Park J, Vo T, An S, Bae S, et al. SAMHD1 acetylation enhances its deoxynucleotide triphosphohydrolase activity and promotes cancer cell proliferation. Oncotarget. 2017;8:68517-68529 pubmed publisher
    b>SAM domain and HD domain containing protein 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that inhibits retroviruses by depleting intracellular deoxynucleotide triphosphates (dNTPs) in non-cycling myeloid cells...
  60. Misra A, Thippeshappa R, Kimata J. Macaques as model hosts for studies of HIV-1 infection. Front Microbiol. 2013;4:176 pubmed publisher
    ..Further studies of these macaque models of infection with HIV-1 derivatives could provide valuable insights into the interaction of lentiviruses and the innate immune response and how lentiviruses adapt and cause disease. ..
  61. Malim M. HIV: Ringside views. Nature. 2014;505:167-8 pubmed publisher
  62. Fiehn C. Familial Chilblain Lupus - What Can We Learn from Type I Interferonopathies?. Curr Rheumatol Rep. 2017;19:61 pubmed publisher
    ..Most frequent is a mutation of the gene for TREX-1. However, as well cases of families with mutations in the SAMHD1 gene and, recently, with one for the gene that codes for the protein stimulator of interferon genes have been ..