Sam68

Summary

Gene Symbol: Sam68
Description: KH RNA binding domain containing, signal transduction associated 1
Alias: Sam68, p62, p68, KH domain-containing, RNA-binding, signal transduction-associated protein 1, GAP-associated tyrosine phosphoprotein p62 (Sam68), KH domain containing, RNA binding, signal transduction associated 1, p21 Ras GTPase-activating protein-associated p62, src-associated in mitosis 68 kDa protein
Species: human
Products:     Sam68

Top Publications

  1. Paronetto M, Venables J, Elliott D, Geremia R, Rossi P, Sette C. Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68. Oncogene. 2003;22:8707-15 pubmed
    ..Western blot analysis indicates that one of these proteins is Sam68, an RNA-binding protein that is known to interact with and be phosphorylated by Src-like kinases in mitosis...
  2. Reddy T, Xu W, Wong Staal F. General effect of Sam68 on Rev/Rex regulated expression of complex retroviruses. Oncogene. 2000;19:4071-4 pubmed
    We have previously demonstrated that overexpression of Sam68 functionally substitutes for, as well as synergizes with, HIV-1 Rev in RRE-mediated gene expression and virus replication...
  3. Henao Mejia J, He J. Sam68 relocalization into stress granules in response to oxidative stress through complexing with TIA-1. Exp Cell Res. 2009;315:3381-95 pubmed publisher
    b>Sam68 has been implicated in a variety of important cellular processes such as RNA metabolism and intracellular signaling...
  4. Sanchez Margalet V, Najib S. p68 Sam is a substrate of the insulin receptor and associates with the SH2 domains of p85 PI3K. FEBS Lett. 1999;455:307-10 pubmed
    ..This association may be important for the link of the signaling with RNA metabolism. ..
  5. Li J, Liu Y, Park I, He J. Expression of exogenous Sam68, the 68-kilodalton SRC-associated protein in mitosis, is able to alleviate impaired Rev function in astrocytes. J Virol. 2002;76:4526-35 pubmed
    ..MG as a model, we report here that HIV-1 gene expression down-regulated expression of Sam68, the 68-kDa Src-associated protein in mitosis, which was constitutively expressed at a lower level in astrocytes...
  6. Resnick R, Taylor S, Lin Q, Shalloway D. Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis. Oncogene. 1997;15:1247-53 pubmed
    b>Sam68 (Src-associated in mitosis) is an SH3 (Src-homology 3), SH2 (Src-homology 2), and RNA binding protein which associates with and is tyrosine phosphorylated by wild-type and activated forms of c-Src in a mitosis-specific manner...
  7. Yang J, Reddy T, Truong K, Suhasini M, Wong Staal F. Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K. Oncogene. 2002;21:7187-94 pubmed
    b>Sam68 is a target of the c-Src tyrosine kinase...
  8. Paronetto M, Cappellari M, Busà R, Pedrotti S, Vitali R, Comstock C, et al. Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. Cancer Res. 2010;70:229-39 pubmed publisher
    ..In this study, we report that Sam68, an RNA-binding protein frequently overexpressed in prostate cancer cells, enhances splicing of cyclin D1b and ..
  9. Pedrotti S, Bielli P, Paronetto M, Ciccosanti F, Fimia G, Stamm S, et al. The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO J. 2010;29:1235-47 pubmed publisher
    ..We observed that the C-to-T transition in SMN2 creates a putative binding site for the RNA-binding protein Sam68. RNA pull-down assays and UV-crosslink experiments showed that Sam68 binds to this sequence...

More Information

Publications69

  1. Wong G, Muller O, Clark R, Conroy L, Moran M, Polakis P, et al. Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62. Cell. 1992;69:551-8 pubmed
    b>p62 is a tyrosine phosphoprotein that associates with p21ras GTPase-activating protein (GAP). Purification and cDNA cloning of p62 reveal extensive sequence similarity to a putative hnRNP protein, GRP33...
  2. Najib S, Martin Romero C, Gonzalez Yanes C, Sanchez Margalet V. Role of Sam68 as an adaptor protein in signal transduction. Cell Mol Life Sci. 2005;62:36-43 pubmed
    b>Sam68, the substrate of Src in mitosis, belongs to the family of RNA binding proteins. Sam68 contains consensus sequences to interact with other proteins via specific domains...
  3. He J, Henao Mejia J, Liu Y. Sam68 functions in nuclear export and translation of HIV-1 RNA. RNA Biol. 2009;6:384-6 pubmed
    ..Src-associated protein of 68 kDa in mitosis (Sam68) is a multi-functional RNA-binding protein and has been implicated in several important cellular processes...
  4. Tremblay G, Richard S. mRNAs associated with the Sam68 RNA binding protein. RNA Biol. 2006;3:90-3 pubmed
    The Src associated substrate in mitosis of 68kDa, Sam68, is an RNA-binding protein that belongs to the KH domain family of proteins...
  5. Hartmann A, Nayler O, Schwaiger F, Obermeier A, Stamm S. The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn). Mol Biol Cell. 1999;10:3909-26 pubmed
    ..transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. Northern blot analysis demonstrated ubiquitous expression, but detailed RNA in situ analysis revealed cell type ..
  6. Sellier C, Rau F, Liu Y, Tassone F, Hukema R, Gattoni R, et al. Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients. EMBO J. 2010;29:1248-61 pubmed publisher
    ..It has been proposed that FXTAS is caused by titration of RNA-binding proteins by the expanded CGG repeats. Sam68 is an RNA-binding protein involved in alternative splicing regulation and its ablation in mouse leads to motor ..
  7. Reddy T, Tang H, Xu W, Wong Staal F. Sam68, RNA helicase A and Tap cooperate in the post-transcriptional regulation of human immunodeficiency virus and type D retroviral mRNA. Oncogene. 2000;19:3570-5 pubmed
    ..Recently, we reported that expression of RRE-containing RNA could also be mediated by a cellular protein, Sam68, independently of Rev...
  8. Richard S, Yu D, Blumer K, Hausladen D, Olszowy M, Connelly P, et al. Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1. Mol Cell Biol. 1995;15:186-97 pubmed
    ..By using the yeast two-hybrid system, we identified p62, a tyrosine-phosphorylated protein that associates with p21ras GTPase-activating protein, as a src family kinase ..
  9. Hong W, Resnick R, Rakowski C, Shalloway D, Taylor S, Blobel G. Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68. Mol Cancer Res. 2002;1:48-55 pubmed
    ..We identified the Src substrate and RNA-binding protein Sam68 as novel CH3-binding protein...
  10. Marsh K, Soros V, Cochrane A. Selective translational repression of HIV-1 RNA by Sam68DeltaC occurs by altering PABP1 binding to unspliced viral RNA. Retrovirology. 2008;5:97 pubmed publisher
    ..Previous analyses have demonstrated that Sam68 and a mutant thereof, Sam68DeltaC, have dramatic effects on HIV gene expression, strongly enhancing and inhibiting ..
  11. Henao Mejia J, Liu Y, Park I, Zhang J, Sanford J, He J. Suppression of HIV-1 Nef translation by Sam68 mutant-induced stress granules and nef mRNA sequestration. Mol Cell. 2009;33:87-96 pubmed publisher
    ..Here we show that Sam68 cytoplasmic mutants potently suppress Nef expression...
  12. Taylor S, Shalloway D. An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis. Nature. 1994;368:867-71 pubmed
    ..p68 is closely related to the p62 protein that is associated with the Ras GTPase-activating protein (GAP) and selectively binds, directly or ..
  13. Suhasini M, Reddy T. Cellular proteins and HIV-1 Rev function. Curr HIV Res. 2009;7:91-100 pubmed
    ..Therefore, we will here focus on other Rev cofactors (eIF5a, hRIP, Sam68, RNA helicases, etc) and the role they play in Rev/RRE function and HIV-1 replication.
  14. Derry J, Richard S, Valderrama Carvajal H, Ye X, Vasioukhin V, Cochrane A, et al. Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability. Mol Cell Biol. 2000;20:6114-26 pubmed
    ..Here we demonstrate that Sik and BRK associate with the RNA binding protein Sam68 (Src associated during mitosis, 68 kDa)...
  15. Jabado N, Pallier A, Le Deist F, Bernard F, Fischer A, Hivroz C. CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation. J Immunol. 1997;158:94-103 pubmed
    ..This PLCgamma1-associated p62 was found to be immunoreactive to p62-Sam68 Abs...
  16. Modem S, Badri K, Holland T, Reddy T. Sam68 is absolutely required for Rev function and HIV-1 production. Nucleic Acids Res. 2005;33:873-9 pubmed
    b>Sam68 functionally complements for, as well as synergizes with, HIV-1 Rev in Rev response element (RRE)-mediated gene expression and virus production...
  17. Locatelli A, Lange C. Met receptors induce Sam68-dependent cell migration by activation of alternate extracellular signal-regulated kinase family members. J Biol Chem. 2011;286:21062-72 pubmed publisher
    ..CD44v5 protein expression and HaCaT cell migration; these events required activation of the ERK1/2 MAPK module and Sam68, a protein involved in RNA processing, splicing, and v5 inclusion...
  18. Liao W, Liu J, Wang Z, Cui Y, Shi L, Li T, et al. High expression level and nuclear localization of Sam68 are associated with progression and poor prognosis in colorectal cancer. BMC Gastroenterol. 2013;13:126 pubmed publisher
    Src-associated in mitosis (Sam68; 68 kDa) has been implicated in the oncogenesis and progression of several human cancers...
  19. Li Z, Yu C, Zhong Y, Liu T, Huang Q, Zhao X, et al. Sam68 expression and cytoplasmic localization is correlated with lymph node metastasis as well as prognosis in patients with early-stage cervical cancer. Ann Oncol. 2012;23:638-46 pubmed publisher
    This study was aimed at investigating the role and molecular mechanism of Sam68 in cervical cancer lymph node metastasis...
  20. Babic I, Jakymiw A, Fujita D. The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity. Oncogene. 2004;23:3781-9 pubmed
    b>Sam68 (Src-associated in mitosis; 68 kDa) is a member of the STAR (signal transduction and activation of RNA) family of KH domain-containing RNA binding proteins...
  21. Li J, Liu Y, Kim B, He J. Direct participation of Sam68, the 68-kilodalton Src-associated protein in mitosis, in the CRM1-mediated Rev nuclear export pathway. J Virol. 2002;76:8374-82 pubmed
    ..We have recently shown that expression of Sam68, the 68-kDa Src-associated protein in mitosis, is able to alleviate Rev function block in astrocytes by promoting ..
  22. Trub T, Frantz J, Miyazaki M, Band H, Shoelson S. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. J Biol Chem. 1997;272:894-902 pubmed
    ..Ras guanine nucleotide exchange factor; with dynamin, a GTPase involved in membrane protein trafficking; and with Sam68, a nuclear RNA-binding protein that serves as a substrate of Src kinases during mitosis...
  23. Taylor S, Anafi M, Pawson T, Shalloway D. Functional interaction between c-Src and its mitotic target, Sam 68. J Biol Chem. 1995;270:10120-4 pubmed
    ..The results suggest that the selection of Sam 68 as a mitotic target by c-Src is the result of highly specific interaction with SH2 and SH3 domains and that this interaction may modulate the RNA binding activity of Sam 68...
  24. Barlat I, Maurier F, Duchesne M, Guitard E, Tocque B, Schweighoffer F. A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain. J Biol Chem. 1997;272:3129-32 pubmed
    b>Sam68 is the main tyrosine-phosphorylated and Src-associated protein in mitotic cells. Sam68 exhibits a conserved functional KH (hnRNPK homology) RNA binding domain and binds single strand nucleic acids...
  25. Rajan P, Dalgliesh C, Bourgeois C, Heiner M, Emami K, Clark E, et al. Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies. BMC Cell Biol. 2009;10:82 pubmed publisher
    ..b>Sam68 (Src-associated in mitosis 68 kDa) is the prototypic member of the STAR (Signal Transduction and Activation of RNA)..
  26. Babic I, Cherry E, Fujita D. SUMO modification of Sam68 enhances its ability to repress cyclin D1 expression and inhibits its ability to induce apoptosis. Oncogene. 2006;25:4955-64 pubmed
    b>Sam68 (Src associated in mitosis; 68 kDa) is an RNA-binding protein and substrate of Src family kinases. It is thought to play a role in cell cycle progression...
  27. Meyer N, Tripsianes K, Vincendeau M, Madl T, Kateb F, Brack Werner R, et al. Structural basis for homodimerization of the Src-associated during mitosis, 68-kDa protein (Sam68) Qua1 domain. J Biol Chem. 2010;285:28893-901 pubmed publisher
    b>Sam68 (Src-associated during mitosis, 68 kDa) is a prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins...
  28. Chen T, Damaj B, Herrera C, Lasko P, Richard S. Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and Qk1: role of the KH domain. Mol Cell Biol. 1997;17:5707-18 pubmed
    b>Sam68 is a member of a growing family of proteins that contain a single KH domain embedded in a larger conserved domain of approximately 170 amino acids...
  29. Soros V, Carvajal H, Richard S, Cochrane A. Inhibition of human immunodeficiency virus type 1 Rev function by a dominant-negative mutant of Sam68 through sequestration of unspliced RNA at perinuclear bundles. J Virol. 2001;75:8203-15 pubmed
    ..It has previously been reported that Sam68 synergistically stimulates Rev activity (T. Reddy et al., Nat. Med. 5:635-642, 1999)...
  30. Fusaki N, Iwamatsu A, Iwashima M, Fujisawa J. Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling. J Biol Chem. 1997;272:6214-9 pubmed
    ..Purification and microsequencing of this protein revealed that it was the RNA-binding protein, Sam68 (Src associated in mitosis, 68 kDa)...
  31. Ramakrishnan P, Baltimore D. Sam68 is required for both NF-?B activation and apoptosis signaling by the TNF receptor. Mol Cell. 2011;43:167-79 pubmed publisher
    The RNA-binding protein Sam68 is implicated in various cellular processes including RNA metabolism, apoptosis, and signal transduction. Here we identify a role of Sam68 in TNF-induced NF-?B activation and apoptosis...
  32. Najib S, Sanchez Margalet V. Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling. J Cell Biochem. 2002;86:99-106 pubmed
    The 68 kDa Src substrate associated during mitosis (Sam68) is an RNA binding protein with Src homology (SH) 2 and 3 domain binding sites...
  33. Valacca C, Bonomi S, Buratti E, Pedrotti S, Baralle F, Sette C, et al. Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene. J Cell Biol. 2010;191:87-99 pubmed publisher
    ..Overexpression and small interfering RNA experiments implicate the splicing regulator Sam68 in AS-NMD of SF2/ASF transcripts and in the choice between EMT/MET programs...
  34. Stoss O, Olbrich M, Hartmann A, Konig H, Memmott J, Andreadis A, et al. The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites. J Biol Chem. 2001;276:8665-73 pubmed
    We identified the rat Sam68-like mammalian protein (rSLM-2), a member of the STAR (signal transduction and activation of RNA) protein family as a novel splicing regulatory protein...
  35. Locatelli A, Lofgren K, Daniel A, Castro N, Lange C. Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression. Horm Cancer. 2012;3:14-25 pubmed publisher
    ..recently identified novel downstream mediators of HGF/Met signaling, Breast tumor kinase (Brk/PTK6), and Src-associated substrate during mitosis of 68 kDa (Sam68), and discuss their relevance to mechanisms of breast cancer progression.
  36. Lukong K, Larocque D, Tyner A, Richard S. Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression. J Biol Chem. 2005;280:38639-47 pubmed
    ..Although BRK is known to phosphorylate the RNA-binding protein Sam68, the specific tyrosines phosphorylated and the exact role of this phosphorylation remains unknown...
  37. Zhang J, Liu Y, Henao J, Rugeles M, Li J, Chen T, et al. Requirement of an additional Sam68 domain for inhibition of human immunodeficiency virus type 1 replication by Sam68 dominant negative mutants lacking the nuclear localization signal. Gene. 2005;363:67-76 pubmed
    ..Evidence has accumulated to suggest that Sam68 plays an important role in HIV-1 replication through HIV-1 Rev protein...
  38. Sánchez Jiménez F, Pérez Pérez A, Gonzalez Yanes C, Najib S, Varone C, Sanchez Margalet V. Leptin receptor activation increases Sam68 tyrosine phosphorylation and expression in human trophoblastic cells. Mol Cell Endocrinol. 2011;332:221-7 pubmed publisher
    ..We have previously implicated the RNA-binding protein Sam68 in leptin signal transduction in immune cells...
  39. Reddy T, Xu W, Mau J, Goodwin C, Suhasini M, Tang H, et al. Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev. Nat Med. 1999;5:635-42 pubmed
    ..Here we show that a cellular nuclear protein, Sam68 (Src-associated protein in mitosis), specifically interacts with RRE and can partially substitute for as well as ..
  40. Morishita E, Murayama K, Kato Murayama M, Ishizuka Katsura Y, Tomabechi Y, Hayashi T, et al. Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68. Structure. 2011;19:1496-508 pubmed publisher
    ..of the complex of APC-Arm with the tyrosine-rich (YY) domain of the Src-associated in mitosis, 68 kDa protein (Sam68), which regulates TCF-1 alternative splicing...
  41. Paronetto M, Achsel T, Massiello A, Chalfant C, Sette C. The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x. J Cell Biol. 2007;176:929-39 pubmed
    The RNA-binding protein Sam68 is involved in apoptosis, but its cellular mRNA targets and its mechanism of action remain unknown. We demonstrate that Sam68 binds the mRNA for Bcl-x and affects its alternative splicing...
  42. Bielli P, Busà R, Paronetto M, Sette C. The RNA-binding protein Sam68 is a multifunctional player in human cancer. Endocr Relat Cancer. 2011;18:R91-R102 pubmed publisher
    Src associated in mitosis, of 68?kDa (Sam68) is a KH domain RNA-binding protein that belongs to the signal transduction and activation of RNA family...
  43. Sanchez Jimenez F, Perez Perez A, Gonzalez Yanes C, Varone C, Sanchez Margalet V. Sam68 mediates leptin-stimulated growth by modulating leptin receptor signaling in human trophoblastic JEG-3 cells. Hum Reprod. 2011;26:2306-15 pubmed publisher
    b>Sam68, a member of the signal transduction and activation of RNA metabolism (STAR) family of RNA-binding proteins, has been previously implicated as an adaptor molecule in different signaling systems, including leptin receptor (LEPR) ..
  44. Andreotti A, Bunnell S, Feng S, Berg L, Schreiber S. Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature. 1997;385:93-7 pubmed
    ..prevents the Itk SH3 domain and proline-rich region from interacting with their respective protein ligands, Sam68 and Grb-2...
  45. Bielli P, Bus R, Di Stasi S, Munoz M, Botti F, Kornblihtt A, et al. The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis. EMBO Rep. 2014;15:419-27 pubmed publisher
    ..FBI-1 interacts with the splicing factor SAM68 and reduces its binding to BCL-X mRNA...
  46. Lawe D, Hahn C, Wong A. The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68. Oncogene. 1997;14:223-31 pubmed
    ..The major target of c-Src during mitosis is SAM68, a RNA-binding protein ordinarily localized to the nucleus...
  47. Cheung N, Chan L, Thompson A, Cleary M, So C. Protein arginine-methyltransferase-dependent oncogenesis. Nat Cell Biol. 2007;9:1208-15 pubmed
    ..Direct fusion of MLL with PRMT1 or Sam68, a bridging molecule in the complex for PRMT1 interaction, could enhance self-renewal of primary haematopoietic ..
  48. Zhang Z, Li J, Zheng H, Yu C, Chen J, Liu Z, et al. Expression and cytoplasmic localization of SAM68 is a significant and independent prognostic marker for renal cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2009;18:2685-93 pubmed publisher
    This retrospective study aimed to examine the expression and localization of SAM68 (Src-associated in mitosis, 68 kDa) in a larger cohort of surgical specimens of renal cell carcinoma and their correlation with the progression of human ..
  49. Venables J, Vernet C, Chew S, Elliott D, Cowmeadow R, Wu J, et al. T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis. Hum Mol Genet. 1999;8:959-69 pubmed
    ..cDNA, the most frequent isolates encoded a novel RNA-binding protein, termed T-STAR, that is closely related to SAM68, an Src-associated protein of unknown function. The mouse homologue was also cloned and designated étoile...
  50. Richard S, Torabi N, Franco G, Tremblay G, Chen T, Vogel G, et al. Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. PLoS Genet. 2005;1:e74 pubmed
    The Src substrate associated in mitosis of 68 kDa (Sam68) is a KH-type RNA binding protein that has been shown to regulate several aspects of RNA metabolism; however, its physiologic role has remained elusive...
  51. Bedford M, Frankel A, Yaffe M, Clarke S, Leder P, Richard S. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. J Biol Chem. 2000;275:16030-6 pubmed
    ..Here we demonstrate that the proposed adapter protein for Src kinases, Sam68, is a ligand whose proline-rich motifs interact with the SH3 domains of p59(fyn) and phospholipase Cgamma-1 as ..
  52. Hawkins J, Marcy A. Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity. Protein Expr Purif. 2001;22:211-9 pubmed
    ..of the rates of phosphorylation of various protein substrates, including Src associated in mitosis 68K protein (SAM68), CD28, linker for activation of T cells, and CD3 zeta, at a fixed concentration indicated that SAM68 was ..
  53. Batsche E, Yaniv M, Muchardt C. The human SWI/SNF subunit Brm is a regulator of alternative splicing. Nat Struct Mol Biol. 2006;13:22-9 pubmed
    ..Consistent with this, Brm associates with several components of the spliceosome and with Sam68, an ERK-activated enhancer of variant exon inclusion...
  54. Sanchez Margalet V, Martin Romero C. Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell Immunol. 2001;211:30-6 pubmed
    ..Moreover, leptin stimulated tyrosine phosphorylation of the RNA binding protein Sam68 and its association with STAT-3. These effects were dose-dependent (0.1-10 nM) and transient (5-30 min)...
  55. Cote J, Boisvert F, Boulanger M, Bedford M, Richard S. Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell. 2003;14:274-87 pubmed
    ..Herein, we report that Sam68, a heteronuclear ribonucleoprotein K homology domain containing RNA binding protein, associates with and is ..
  56. Matter N, Herrlich P, König H. Signal-dependent regulation of splicing via phosphorylation of Sam68. Nature. 2002;420:691-5 pubmed
    ..We show that the nuclear RNA-binding protein Sam68 is a new extracellular signal-regulated kinase (ERK) target...
  57. Chen Z, Cai L, Zhu J, Chen M, Chen J, Li Z, et al. Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer. Carcinogenesis. 2011;32:1419-26 pubmed publisher
    The Src family kinase Fyn, heterogenous nuclear ribonucleoprotein (HnRNP) A2B1 and Sam68 are thought to be associated with the metastasis of tumors, but their roles in the regulation of apoptosis remain unclear...
  58. Sanchez Margalet V, Najib S. Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling. Mol Cell Endocrinol. 2001;183:113-21 pubmed
    The 68 kDa Src substrate associated during mitosis (Sam68) is an RNA binding protein with Src homology (SH) 2 and 3 domain binding sites...
  59. Coyle J, Guzik B, Bor Y, Jin L, Eisner Smerage L, Taylor S, et al. Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK. Mol Cell Biol. 2003;23:92-103 pubmed
    ..However, addition of Sam68 led to a dramatic increase in the amount of Gag-Pol proteins produced in these cells...