SALL4

Summary

Gene Symbol: SALL4
Description: spalt like transcription factor 4
Alias: DRRS, HSAL4, ZNF797, sal-like protein 4, zinc finger protein 797, zinc finger protein SALL4
Species: human
Products:     SALL4

Top Publications

  1. Paradisi I, Arias S. IVIC syndrome is caused by a c.2607delA mutation in the SALL4 locus. Am J Med Genet A. 2007;143:326-32 pubmed
    ..Since 2002, mutations in the SALL4 locus have been reported producing phenotypic features quite similar to those in IVIC syndrome; this gene was thus ..
  2. Kohlhase J, Heinrich M, Schubert L, Liebers M, Kispert A, Laccone F, et al. Okihiro syndrome is caused by SALL4 mutations. Hum Mol Genet. 2002;11:2979-87 pubmed
    ..We have characterized the human SALL4 gene on chromosome 20q13.13-q13.2...
  3. Haus A, Kohlhase J, Käsmann B, Seitz B. [Okihiro syndrome : Duane's syndrome and radial malformations of the limbs]. Ophthalmologe. 2008;105:588-91 pubmed publisher
  4. Yang J, Gao C, Chai L, Ma Y. A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells. PLoS ONE. 2010;5:e10766 pubmed publisher
    b>SALL4 is a member of the SALL gene family that encodes a group of putative developmental transcription factors. Murine Sall4 plays a critical role in maintaining embryonic stem cell (ES cell) pluripotency and self-renewal...
  5. Kohlhase J, Holmes L. Mutations in SALL4 in malformed father and daughter postulated previously due to reflect mutagenesis by thalidomide. Birth Defects Res A Clin Mol Teratol. 2004;70:550-1 pubmed
  6. Yang J, Liao W, Ma Y. Role of SALL4 in hematopoiesis. Curr Opin Hematol. 2012;19:287-91 pubmed publisher
    Stem cell gene SALL4 has been well characterized for its essential role in developmental events as well as embryonic stem cell pluripotency maintenance...
  7. Wang F, Liu A, Peng Y, Rakheja D, Wei L, Xue D, et al. Diagnostic utility of SALL4 in extragonadal yolk sac tumors: an immunohistochemical study of 59 cases with comparison to placental-like alkaline phosphatase, alpha-fetoprotein, and glypican-3. Am J Surg Pathol. 2009;33:1529-39 pubmed publisher
    ..In earlier studies with gonadal germ cell tumors, SALL4 has been identified as a novel diagnostic marker for YSTs and other types of primitive germ cell tumors...
  8. Yang J, Chai L, Fowles T, Alipio Z, Xu D, Fink L, et al. Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. Proc Natl Acad Sci U S A. 2008;105:19756-61 pubmed publisher
    Embryonic stem cells have potential utility in regenerative medicine because of their pluripotent characteristics. Sall4, a zinc-finger transcription factor, is expressed very early in embryonic development with Oct4 and Nanog, two well-..
  9. Yang J, Chai L, Gao C, Fowles T, Alipio Z, Dang H, et al. SALL4 is a key regulator of survival and apoptosis in human leukemic cells. Blood. 2008;112:805-13 pubmed publisher
    Increasing studies suggest that SALL4 may play vital roles in leukemogenesis and stem cell phenotypes...

More Information

Publications86

  1. Kohlhase J, Schubert L, Liebers M, Rauch A, Becker K, Mohammed S, et al. Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy. J Med Genet. 2003;40:473-8 pubmed
    ..recently shown that Okihiro syndrome results from mutation in the putative zinc finger transcription factor gene SALL4 on chromosome 20q13.13-13.2...
  2. Borozdin W, Wright M, Hennekam R, Hannibal M, Crow Y, Neumann T, et al. Novel mutations in the gene SALL4 provide further evidence for acro-renal-ocular and Okihiro syndromes being allelic entities, and extend the phenotypic spectrum. J Med Genet. 2004;41:e102 pubmed
  3. Al Baradie R, Yamada K, St Hilaire C, Chan W, Andrews C, McIntosh N, et al. Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family. Am J Hum Genet. 2002;71:1195-9 pubmed
    ..A new member of the SAL family of proposed C(2)H(2) zinc finger transcription factors, SALL4, falls within the region...
  4. Cao D, Li J, Guo C, Allan R, Humphrey P. SALL4 is a novel diagnostic marker for testicular germ cell tumors. Am J Surg Pathol. 2009;33:1065-77 pubmed publisher
    ..Here we performed an immunohistochemical study of a novel stem cell marker SALL4 in a large series of 110 primary testicular GCTs (65 pure and 45 mixed) containing the following types of tumors ..
  5. Lu J, Jeong H, Jeong H, Kong N, Yang Y, Carroll J, et al. Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. PLoS ONE. 2009;4:e5577 pubmed publisher
    The embryonic stem cell (ESC) factor, SALL4, plays an essential role in both development and leukemogenesis. It is a unique gene that is involved in self-renewal in ESC and leukemic stem cell (LSC)...
  6. Jeong H, Cui W, Yang Y, Lu J, He J, Li A, et al. SALL4, a stem cell factor, affects the side population by regulation of the ATP-binding cassette drug transport genes. PLoS ONE. 2011;6:e18372 pubmed publisher
    Our previous work shows that the stem cell factor SALL4 plays a central role in embryonic and leukemic stem cells...
  7. Yong K, Gao C, Lim J, Yan B, Yang H, Dimitrov T, et al. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med. 2013;368:2266-76 pubmed publisher
    ..The oncofetal gene SALL4, a marker of a subtype of hepatocellular carcinoma with progenitor-like features, is associated with a poor ..
  8. Ushiku T, Shinozaki A, Shibahara J, Iwasaki Y, Tateishi Y, Funata N, et al. SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma. Am J Surg Pathol. 2010;34:533-40 pubmed publisher
    The novel stem cell marker SALL4 has been identified as a diagnostic marker of germ cell tumors, especially yolk sac tumors, in gonadal organs...
  9. Wabbels B, Lorenz B, Kohlhase J. No evidence of SALL4-mutations in isolated sporadic duane retraction "syndrome" (DURS). Am J Med Genet A. 2004;131:216-8 pubmed
  10. Lin J, Qian J, Yao D, Qian W, Yang J, Wang C, et al. Aberrant hypomethylation of SALL4 gene in patients with myelodysplastic syndrome. Leuk Res. 2013;37:71-5 pubmed publisher
    The abnormalities of SALL4 gene, which encodes a zinc-finger transcription factor and is essential for developmental events, have been found to be involved in tumorigenesis...
  11. Shuai X, Zhou D, Shen T, Wu Y, Zhang J, Wang X, et al. Overexpression of the novel oncogene SALL4 and activation of the Wnt/beta-catenin pathway in myelodysplastic syndromes. Cancer Genet Cytogenet. 2009;194:119-24 pubmed publisher
    ..The cytogenetic and molecular pathogenesis of MDS has not been well understood. SALL4, a newly identified oncogene, modulates stem cell pluripotency and self-renewal capability in embryonic ..
  12. Zeng S, Yamashita T, Kondo M, Nio K, Hayashi T, Hara Y, et al. The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma. J Hepatol. 2014;60:127-34 pubmed publisher
    ..The relationship of the transcription factor and prognosis was statistically examined. The transcription factor SALL4, known to regulate stemness in embryonic and hematopoietic stem cells, was found to be activated in a ..
  13. Wong C, Gaspar Maia A, Ramalho Santos M, Reijo Pera R. High-efficiency stem cell fusion-mediated assay reveals Sall4 as an enhancer of reprogramming. PLoS ONE. 2008;3:e1955 pubmed publisher
    ..Moreover, we demonstrate that overexpression of the Spalt transcription factor, Sall4, which was previously identified as a regulator of embryonic stem cell pluripotency and early mouse development, ..
  14. Itou J, Matsumoto Y, Yoshikawa K, Toi M. Sal-like 4 (SALL4) suppresses CDH1 expression and maintains cell dispersion in basal-like breast cancer. FEBS Lett. 2013;587:3115-21 pubmed publisher
    In cell cultures, the dispersed phenotype is indicative of the migratory ability. Here we characterized Sal-like 4 (SALL4) as a dispersion factor in basal-like breast cancer...
  15. Cao D, Guo S, Allan R, Molberg K, Peng Y. SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. Am J Surg Pathol. 2009;33:894-904 pubmed publisher
    ..Here by immunohistochemistry, we investigated a novel marker SALL4 in 98 GCTs (29 YSTs, 18 dysgerminomas, 6 gonadoblastomas, 6 embryonal carcinomas, 15 immature and 12 mature ..
  16. Gao C, Kong N, Li A, Tatetu H, Ueno S, Yang Y, et al. SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53:1037-49 pubmed publisher
    Stem cell factor SALL4 is a zinc finger transcription factor. It plays vital roles in the maintenance of embryonic stem cell properties, functions as an oncogene in leukemia, and has been recently proposed to use for cord blood expansion...
  17. Kobayashi D, Kuribayashi K, Tanaka M, Watanabe N. Overexpression of SALL4 in lung cancer and its importance in cell proliferation. Oncol Rep. 2011;26:965-70 pubmed publisher
    ..Herein, we present the first evidence for mRNA overexpression of SALL4, a transcription factor essential for embryonic development and the self-renewal of embryonic stem cells, in lung ..
  18. Yang J, Chai L, Liu F, Fink L, Lin P, Silberstein L, et al. Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc Natl Acad Sci U S A. 2007;104:10494-9 pubmed
    Bmi-1 and SALL4 are putative oncogenes that modulate stem cell pluripotency and play a role in leukemogenesis...
  19. Bard J, Gelebart P, Amin H, Young L, Ma Y, Lai R. Signal transducer and activator of transcription 3 is a transcriptional factor regulating the gene expression of SALL4. FASEB J. 2009;23:1405-14 pubmed publisher
    Both signal transducer and activator of transcription 3 (STAT3) and SALL4 are important in maintaining the pluripotent and self-renewal state of embryonic stem cells...
  20. Kohlhase J, Chitayat D, Kotzot D, Ceylaner S, Froster U, Fuchs S, et al. SALL4 mutations in Okihiro syndrome (Duane-radial ray syndrome), acro-renal-ocular syndrome, and related disorders. Hum Mutat. 2005;26:176-83 pubmed
    ..The disease is the result of a mutation in the SALL4 gene, a human gene related to the developmental regulator spalt (sal) of Drosophila melanogaster...
  21. Arya L, Kumar A, Shetty S, Perumalsamy V, Sundaresan P. Analysis of the SALL4 gene in patients with Duane retraction syndrome in a South Indian population. Ophthalmic Genet. 2011;32:156-7 pubmed publisher
    ..Recently mutations of the SALL4 gene on chromosome 20 have been linked to DRS associated with radial forearm malformations (Okihiro syndrome)...
  22. Mei K, Liu A, Allan R, Wang P, Lane Z, Abel T, et al. Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: a study of 77 cases. Mod Pathol. 2009;22:1628-36 pubmed publisher
    ..In this study we analyzed the diagnostic utility of a novel marker, SALL4, in 77 such tumors (59 pure and 18 mixed) consisting of the following tumors/tumor components: 49 germinomas, 7 ..
  23. Kobayashi D, Kuribayshi K, Tanaka M, Watanabe N. SALL4 is essential for cancer cell proliferation and is overexpressed at early clinical stages in breast cancer. Int J Oncol. 2011;38:933-9 pubmed publisher
    ..Here, we present the first evidence for diagnostic performance of gene expression for SALL4, a transcription factor that plays an essential role in the embryonic development and self-renewal of embryonic ..
  24. Deisch J, Raisanen J, Rakheja D. Immunoexpression of SALL4 in Wilms tumors and developing kidney. Pathol Oncol Res. 2011;17:639-44 pubmed publisher
    b>SALL4 is a zinc finger transcription factor that plays a role in the maintainance and pluripotency of embryonic stem cell and is important in renal development where SALL4 mutations give rise to renal malformations...
  25. Ma Y, Cui W, Yang J, Qu J, Di C, Amin H, et al. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood. 2006;108:2726-35 pubmed
    b>SALL4, a human homolog to Drosophila spalt, is a novel zinc finger transcriptional factor essential for development. We cloned SALL4 and its isoforms (SALL4A and SALL4B)...
  26. Borozdin W, Boehm D, Leipoldt M, Wilhelm C, Reardon W, Clayton Smith J, et al. SALL4 deletions are a common cause of Okihiro and acro-renal-ocular syndromes and confirm haploinsufficiency as the pathogenic mechanism. J Med Genet. 2004;41:e113 pubmed
  27. Sweetman D, Munsterberg A. The vertebrate spalt genes in development and disease. Dev Biol. 2006;293:285-93 pubmed
    ..Here we review what is currently known about the role of spalt genes in vertebrate development and human disease. ..
  28. Kilic E, Tennstedt P, Högner A, Lebok P, Sauter G, Bokemeyer C, et al. The zinc-finger transcription factor SALL4 is frequently expressed in human cancers: association with clinical outcome in squamous cell carcinoma but not in adenocarcinoma of the esophagus. Virchows Arch. 2016;468:483-92 pubmed publisher
    b>SALL4 is a transcription factor originally identified as a homeotic gene essential for organ development. Early studies suggested that SALL4 is a useful marker to identify testicular and ovarian germ cell tumors...
  29. Liang L, Olar A, Niu N, Jiang Y, Cheng W, Bian X, et al. Primary Glial and Neuronal Tumors of the Ovary or Peritoneum: A Clinicopathologic Study of 11 Cases. Am J Surg Pathol. 2016;40:847-56 pubmed publisher
    ..The neurocytoma was positive for synaptophysin and negative for S100 protein, glial fibrillary acidic protein, and SALL4. No IDH1-R132H mutation was detected in 2 of 2 (0%) astrocytomas by immunohistochemistry...
  30. Cheng J, Deng R, Wu C, Zhang P, Wu K, Shi L, et al. Inhibition of SALL4 suppresses carcinogenesis of colorectal cancer via regulating Gli1 expression. Int J Clin Exp Pathol. 2015;8:10092-101 pubmed
    b>SALL4 is a novel oncogene mediating tumorigenesis in multiple carcinomas. However, its actual role and mechanisms participating in the development of colorectal cancer remains unclear...
  31. Oliviero G, Brien G, Waston A, Streubel G, Jerman E, Andrews D, et al. Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. Mol Cell Proteomics. 2016;15:3450-3460 pubmed
    ..For example, SALL4 and ZNF281 associate with PRC2 in pluripotent cells, whereas PCL1 and SMAD3 preferentially associate with PRC2 in ..
  32. Zhang L, Yan Y, Jiang Y, Cui Y, Zou Y, Qian J, et al. The expression of SALL4 in patients with gliomas: high level of SALL4 expression is correlated with poor outcome. J Neurooncol. 2015;121:261-8 pubmed publisher
    The spalt-like transcription factor 4 (SALL4) gene has been demonstrated to be overexpressed in many malignancies, but little is known about its expression in gliomas...
  33. Exner C, Kim A, Mardjuki S, Harland R. sall1 and sall4 repress pou5f3 family expression to allow neural patterning, differentiation, and morphogenesis in Xenopus laevis. Dev Biol. 2017;425:33-43 pubmed publisher
    ..We previously identified the genes sall1 and sall4, known regulators of pluripotency in other contexts, as transcriptional targets of developmental signaling ..
  34. Xia H, Cao J, Li Q, Lv Y, Jia W, Ren W, et al. Hepatocellular Carcinoma-propagating Cells are Detectable by Side Population Analysis and Possess an Expression Profile Reflective of a Primitive Origin. Sci Rep. 2016;6:34856 pubmed publisher
    ..cells express higher levels of pluripotency- and stem cell-associated transcription factors including Klf4, NF-Ya, SALL4 and HMGA2. Some of the known hepatobiliary progenitor/stem cell markers, such as Sox9 was also up-regulated...
  35. Abu Amero K, Kondkar A, Khan A. A microdeletion in the GRHL2 Gene in two unrelated patients with congenital fibrosis of the extra ocular muscles. BMC Res Notes. 2017;10:562 pubmed publisher
    ..extraocular muscles type 1 (CFEOM1) is known to be caused by mutations in KIF21A or TUBB3 or other known genes (SALL4, CHN1, HOXA1). However, affected children may harbor other genetic defects...
  36. Vissiennon T, Freick M, Kilic E, Schmidt T, Dänicke S, Schmicke M, et al. Sertoli cell tumour in a neonate calf: an unusual congenital tumour. A case report. Tierarztl Prax Ausg G Grosstiere Nutztiere. 2016;44:371-378 pubmed
    ..inhibin and S-100 protein, but immunonegative for cytokeratine, CD30, progesterone receptor, ?-fetoprotein, SALL4, OCT4 and glypican-3...
  37. Liu X, Wang S, Xu J, Kou B, Chen D, Wang Y, et al. Extract of Stellerachamaejasme L(ESC) inhibits growth and metastasis of human hepatocellular carcinoma via regulating microRNA expression. BMC Complement Altern Med. 2018;18:99 pubmed publisher
    ..Interestingly, only target genes of hsa-miR-107 changed greatly. ESC downregulated the MCL1, SALL4 and BCL2 gene expressions significantly but did not influence the expression of CACNA2D1...
  38. Gopan O, Zeng J, Novak A, Nyflot M, Ford E. The effectiveness of pretreatment physics plan review for detecting errors in radiation therapy. Med Phys. 2016;43:5181 pubmed publisher
    ..effective at detecting events (combined effectiveness of 38%): verifying the isocenter (39/180), verifying DRRs (17/180), and verifying that the plan matched the prescription (12/180)...
  39. Gassei K, Sheng Y, Fayomi A, Mital P, Sukhwani M, Lin C, et al. DDX4-EGFP transgenic rat model for the study of germline development and spermatogenesis. Biol Reprod. 2017;96:707-719 pubmed publisher
    ..long-term expression of zinc finger and BTB domain containing 16 (ZBTB16) and spalt-like transcription factor 4 (SALL4), two markers of mouse SSCs that are conserved in rats...
  40. Zhang S, Xie Y, Cao H, Wang H. Common microRNA-mRNA interactions exist among distinct porcine iPSC lines independent of their metastable pluripotent states. Cell Death Dis. 2017;8:e3027 pubmed publisher
    ..down the proliferation, and further cause the downregulation of downstream pluripotent genes (OCT4, SOX2, NANOG, SALL4 and ESRRB) and upregulation of differentiation relevant genes (SOX9, JARID2 and JMJD4)...
  41. Alves L, Perez A, Alonso L, Otto P, Mingroni Netto R. Novel frameshift variant in gene SALL4 causing Okihiro syndrome. Eur J Med Genet. 2016;59:80-5 pubmed publisher
    ..It is a rare autosomal dominant disorder determined by variants in the SALL4 gene which encodes a transcription factor with eight zinc finger motifs...
  42. Liu J, Wang P, Huang J, Yu Z. Rethinking genotype-phenotype correlations in papillorenal syndrome: a case report on an unusual congenital camptodactyly and skeletal deformity with a heterogeneous PAX2 mutation of hexanucleotide duplication. Gene. 2018;641:74-77 pubmed publisher
    ..Besides, the absence of Spalt like transcription factor 4 (SALL4) mutation excluded the diagnosis of acro-renal-ocular syndrome (AROS), of which clinical characteristics are ..
  43. Krivega M, Essahib W, Van de Velde H. WNT3 and membrane-associated β-catenin regulate trophectoderm lineage differentiation in human blastocysts. Mol Hum Reprod. 2015;21:711-22 pubmed publisher
    ..We did not observe any effects on the inner cell mass markers NANOG, POU5F1, SOX2 and SALL4 in these functional experiments...
  44. Wang B, Li L, Ni F, Song J, Wang J, Mu Y, et al. Mutational analysis of SAL-Like 4 (SALL4) in Han Chinese women with premature ovarian failure. Mol Hum Reprod. 2009;15:557-62 pubmed publisher
    Pluripotency associated transcription factor, SAL-Like 4 (SALL4), might play an important role in conferring totipotency on oocytes...
  45. Li A, Jiao Y, Yong K, Wang F, Gao C, Yan B, et al. SALL4 is a new target in endometrial cancer. Oncogene. 2015;34:63-72 pubmed publisher
    ..In this study, we find that SALL4, a gene involved in the maintenance of ES cell self-renewal, is aberrantly expressed in 47...
  46. Liu T, Vachharajani N, Chapman W, Brunt E. SALL4 immunoreactivity predicts prognosis in Western hepatocellular carcinoma patients but is a rare event: a study of 236 cases. Am J Surg Pathol. 2014;38:966-72 pubmed publisher
    Prognostic biomarkers that stratify patients with cancer are needed. Recent studies from Asia have implicated SALL4, a stem cell marker, as useful in identifying aggressive cases of hepatocellular carcinoma (HCC), and >50% of the ..
  47. Rozario T, Bereg S, Yan Y, Chiu T, Liu H, Kearney V, et al. An accurate algorithm to match imperfectly matched images for lung tumor detection without markers. J Appl Clin Med Phys. 2015;16:5200 pubmed publisher
    ..In order to locate lung tumors on kV projection images without internal markers, digitally reconstructed radiographs (DRRs) are created and compared with projection images...
  48. Deisch J, Raisanen J, Rakheja D. Immunohistochemical expression of embryonic stem cell markers in malignant rhabdoid tumors. Pediatr Dev Pathol. 2011;14:353-9 pubmed publisher
    ..stem cells, we hypothesized that the human malignant rhabdoid tumors may express pluripotency genes such as SALL4 , LIN28 , OCT3 and OCT4 (OCT3/4) , NANOG , and TCL1 ...
  49. Arumugam S, Sidhom M, Truant D, Xing A, Udovitch M, Holloway L. Variable angle stereo imaging for rapid patient position correction in an in-house real-time position monitoring system. Phys Med. 2017;33:170-178 pubmed publisher
    ..position correction was compared with the manual matching of seed positions in Digitally Reconstructed Radiographs (DRRs) and kV images in the Mosaiq record and verify system...
  50. Lin Y, Liu A, Fan C, Zheng H, Li Y, Zhang C, et al. MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1. Sci Rep. 2015;5:9995 pubmed publisher
    ..through which miR-33b inhibits the stemness, migration and invasion of breast cancer cells is by targeting HMGA2, SALL4 and Twist1...
  51. Cheng J, Deng R, Zhang P, Wu C, Wu K, Shi L, et al. miR-219-5p plays a tumor suppressive role in colon cancer by targeting oncogene Sall4. Oncol Rep. 2015;34:1923-32 pubmed publisher
    b>Sall4 is a novel oncogene found upregulated in several malignancies including colon cancer. However, its upstream regulatory miRNA is still undefined. miR-219-5p is regarded as a tumor-related miRNA in cancer research...
  52. Takasawa K, Arai Y, Yamazaki Inoue M, Toyoda M, Akutsu H, Umezawa A, et al. DNA hypermethylation enhanced telomerase reverse transcriptase expression in human-induced pluripotent stem cells. Hum Cell. 2018;31:78-86 pubmed publisher
    ..human induced pluripotent stem cells (iPSCs), several stem cell marker genes are induced, such as OCT-4, NANOG, SALL4, and TERT. OCT-4, NANOG, and SALL4 gene expression can be regulated by DNA methylation...
  53. Wang H, Kohashi K, Yoshizumi T, Okumura Y, Tanaka Y, Shimokawa M, et al. Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma. Hum Pathol. 2017;64:69-75 pubmed publisher
    Spalt-like transcriptional factor 4 (SALL4), a stem marker, is reactivated in several cancers...
  54. Xu K, Chen X, Yang H, Xu Y, He Y, Wang C, et al. Maternal Sall4 Is Indispensable for Epigenetic Maturation of Mouse Oocytes. J Biol Chem. 2017;292:1798-1807 pubmed publisher
    b>Sall4 (Splat-like 4) plays important roles in maintaining pluripotency of embryonic stem cells and in various developmental processes. Here, we find that Sall4 is highly expressed in oocytes and early embryos...
  55. Forghanifard M, Ardalan Khales S, Javdani Mallak A, Rad A, Farshchian M, Abbaszadegan M. Stemness state regulators SALL4 and SOX2 are involved in progression and invasiveness of esophageal squamous cell carcinoma. Med Oncol. 2014;31:922 pubmed publisher
    ..b>SALL4 and SOX2 are two main transcription factors involving in maintenance of pluripotency, self-renewal and cell fate ..
  56. Liu L, Zhang J, Yang X, Fang C, Xu H, Xi X. SALL4 as an Epithelial-Mesenchymal Transition and Drug Resistance Inducer through the Regulation of c-Myc in Endometrial Cancer. PLoS ONE. 2015;10:e0138515 pubmed publisher
    b>SALL4 plays important roles in the development and progression of many cancers. However, the role and molecular mechanism of SALL4 in endometrial cancer remain elusive...
  57. Lovelace D, Gao Z, Mutoji K, Song Y, Ruan J, Hermann B. The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia. Development. 2016;143:1893-906 pubmed publisher
    ..The transcription factors Sal-like 4 (SALL4) and promyelocytic leukemia zinc finger (PLZF; also known as ZBTB16) are known to be required for normal SSC ..
  58. Habano W, Sugai T, Jiao Y, Nakamura S. Novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy. Int J Cancer. 2007;121:1487-93 pubmed
    ..The putative promoter sequence of the SALL4 (sal-like 4, a human homolog to Drosophila spalt) gene was particularly more frequently hypermethylated in ..
  59. Wang P, Zhang J, Wu F, Ye X, Sharon D, Hitt M, et al. The expression and oncogenic effects of the embryonic stem cell marker SALL4 in ALK-positive anaplastic large cell lymphoma. Cell Signal. 2012;24:1955-63 pubmed publisher
    b>SALL4 is one of the master transcriptional factors that are crucial in maintaining the pluripotency of embryonic stem cells (ESCs)...
  60. Lu J, Ma Y, Kong N, Alipio Z, Gao C, Krause D, et al. Dissecting the role of SALL4, a newly identified stem cell factor, in chronic myelogenous leukemia. Leukemia. 2011;25:1211-3 pubmed publisher
  61. Rad A, Esmaeili Dizghandi S, Abbaszadegan M, Taghechian N, Najafi M, Forghanifard M. SOX1 is correlated to stemness state regulator SALL4 through progression and invasiveness of esophageal squamous cell carcinoma. Gene. 2016;594:171-175 pubmed publisher
    ..samples was assessed compared to related margin normal tissues, and its correlation with CSC markers including SALL4, SOX2, and MEIS1 was analyzed statistically...
  62. Liu C, Wu H, Li Y, Shen L, Yu R, Yin H, et al. SALL4 suppresses PTEN expression to promote glioma cell proliferation via PI3K/AKT signaling pathway. J Neurooncol. 2017;135:263-272 pubmed publisher
    Spalt-like transcription factor 4 (SALL4), a oncogene, is known to participate in multiple carcinomas, and is up-regulated in glioma. However, its actual role and underlying mechanisms in the development of glioma remain unclear...
  63. Han S, Wang J, Guo X, He C, Ying X, Ma J, et al. Serum SALL4 is a novel prognosis biomarker with tumor recurrence and poor survival of patients in hepatocellular carcinoma. J Immunol Res. 2014;2014:262385 pubmed publisher
    Sal-like protein 4 (SALL4), is reexpressed in tissues of a subgroup of HCC associated with poor prognosis. Reports of SALL4 serological levels linked to HCC patients are meager and unclear in the prognosis of this malignancy...
  64. Cao D, Liu A, Wang F, Allan R, Mei K, Peng Y, et al. RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases. Mod Pathol. 2011;24:288-96 pubmed publisher
    ..We compared LIN28 with SALL4 to assess its diagnostic value...
  65. Bai S, Wei S, Ziober A, Yao Y, Bing Z. SALL4 and SF-1 are sensitive and specific markers for distinguishing granulosa cell tumors from yolk sac tumors. Int J Surg Pathol. 2013;21:121-5 pubmed publisher
    ..In this study, the authors performed immunohistochemical stains for SALL4 and steroidogenic factor-1 (SF-1) on 27 cases of yolk sac tumors and 24 granulosa cell tumors...
  66. Milanovich S, Peterson J, Allred J, Stelloh C, Rajasekaran K, Fisher J, et al. Sall4 overexpression blocks murine hematopoiesis in a dose-dependent manner. Exp Hematol. 2015;43:53-64.e1-8 pubmed publisher
    Sal-like protein 4 (SALL4) is a transcription factor that exists in two splice isoforms, SALL4a and SALL4b, and regulates transcription in embryonic stem cells, hematopoiesis, and acute myeloid leukemia...
  67. Zhang L, Xu Z, Xu X, Zhang B, Wu H, Wang M, et al. SALL4, a novel marker for human gastric carcinogenesis and metastasis. Oncogene. 2014;33:5491-500 pubmed publisher
    b>SALL4, a zinc-finger transcriptional factor for embryonic stem cell self-renewal and pluripotency, has been suggested to be involved in tumorigenesis. The role of SALL4 in human gastric cancer, however, remains largely unknown...
  68. Miller A, Ralser M, Kloet S, Loos R, Nishinakamura R, Bertone P, et al. Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complex. Development. 2016;143:3074-84 pubmed publisher
    b>Sall4 is an essential transcription factor for early mammalian development and is frequently overexpressed in cancer...
  69. Stichelbout M, Devisme L, Franquet Ansart H, Massardier J, Vinatier D, Renaud F, et al. SALL4 expression in gestational trophoblastic tumors: a useful tool to distinguish choriocarcinoma from placental site trophoblastic tumor and epithelioid trophoblastic tumor. Hum Pathol. 2016;54:121-6 pubmed publisher
    b>SALL4 has important functions in embryonic stem cells. The aim of this study was to investigate SALL4 expression in gestational trophoblastic neoplasia...
  70. Wang F, Gao C, Lu J, Tatetsu H, Williams D, Müller L, et al. Leukemic survival factor SALL4 contributes to defective DNA damage repair. Oncogene. 2016;35:6087-6095 pubmed publisher
    b>SALL4 is aberrantly expressed in human myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We have generated a SALL4 transgenic (SALL4B Tg) mouse model with pre-leukemic MDS-like symptoms that transform to AML over time...
  71. Andeen N, Tretiakova M. Metastatic Treated Malignant Germ Cell Tumors: Is SALL4 a Better Marker Than Placental Alkaline Phosphatase?. Appl Immunohistochem Mol Morphol. 2016;24:210-4 pubmed publisher
    ..Transcription factor SALL4 (sal-like protein 4) has been recognized as a sensitive marker for both primary and metastatic malignant germ cell ..
  72. Sisakhtnezhad S, Heshmati P. Comparative analysis of single-cell RNA sequencing data from mouse spermatogonial and mesenchymal stem cells to identify differentially expressed genes and transcriptional regulators of germline cells. J Cell Physiol. 2017;: pubmed publisher
    ..investigation of the expression profiles of genes including in spermatogenesis process revealed that Dazl, Ddx4, Sall4, Fkbp6, Tex15, Tex19.1, Rnf17, Piwil2, Taf7l, Zbtb16 and Cadm1 are presented in the first 30 up-regulated DEGs...
  73. Kim J, Xu S, Xiong L, Yu L, Fu X, Xu Y. SALL4 promotes glycolysis and chromatin remodeling via modulating HP1α-Glut1 pathway. Oncogene. 2017;36:6472-6479 pubmed publisher
    b>SALL4 has recently been identified to promote chemo-resistance in multiple types of cancer, but the underlying mechanism remains to be fully established. Open chromatin structure is important for DNA damage response (DDR) and DNA repair...
  74. Zhou S, Venkatramani R, Gomulia E, Shillingford N, Wang L. The diagnostic and prognostic value of SALL4 in hepatoblastoma. Histopathology. 2016;69:822-830 pubmed publisher
    To investigate the expression of spalt-like transcription factor 4 (SALL4), a regulator of embryonal development, in three epithelial components of hepatoblastoma (HB) and the relationship between SALL4 expression levels and patients' ..
  75. Zhou Y, Peng Y, Liu M, Jiang Y. MicroRNA-181b Inhibits Cellular Proliferation and Invasion of Glioma Cells via Targeting Sal-Like Protein 4. Oncol Res. 2017;25:947-957 pubmed publisher
    ..Sal-like protein 4 (SALL4) was identified as a novel target gene of miR-181b in U251 cells...
  76. Ma J, Qian J, Lin J, Qian W, Yang J, Wang C, et al. Aberrant hypomethylation of SALL4 gene is associated with intermediate and poor karyotypes in acute myeloid leukemia. Clin Biochem. 2013;46:304-7 pubmed publisher
    b>SALL4 gene has been identified to stimulate the expansion of hematopoietic stem cell (HSCs) and enhance the self-renewal of HSCs. Overexpression of SALL4 has been found in several cancers...
  77. Goerres J, Jacobson M, Uneri A, de Silva T, Ketcha M, Reaungamornrat S, et al. Deformable 3D-2D Registration for Guiding K-Wire Placement in Pelvic Trauma Surgery. Proc SPIE Int Soc Opt Eng. 2017;10135: pubmed publisher
    ..The patient is registered to a preoperative CT image by virtually projecting digitally reconstructed radiographs (DRRs) and matching to two or more intraoperative x-ray projections...