S100A9

Summary

Gene Symbol: S100A9
Description: S100 calcium binding protein A9
Alias: 60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14, MRP-14, S100 calcium-binding protein A9 (calgranulin B), calgranulin B, calgranulin-B, calprotectin L1H subunit, leukocyte L1 complex heavy chain, migration inhibitory factor-related protein 14, protein S100-A9
Species: human

Top Publications

  1. ncbi S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity
    Wolfgang Nacken
    Institute of Experimental Dermatology, University of Munster, 48149 Munster, Germany
    Microsc Res Tech 60:569-80. 2003
  2. ncbi Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis
    K Odink
    Department of Biotechnology, Ciba Geigy, Basel, Switzerland
    Nature 330:80-2. 1987
  3. ncbi S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells
    Alexander Hermani
    Research Group Hormones and Signal Transduction, German Cancer Research Centre, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Exp Cell Res 312:184-97. 2006
  4. ncbi Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion
    Carle Ryckman
    Infectious Diseases Research Center, Laval University Hospital Center, Sainte Foy, Quebec, Canada
    J Immunol 170:3233-42. 2003
  5. pmc S100A8 and S100A9: new insights into their roles in malignancy
    Geetha Srikrishna
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    J Innate Immun 4:31-40. 2012
  6. pmc Induction of nuclear factor-κB responses by the S100A9 protein is Toll-like receptor-4-dependent
    Matteo Riva
    Immunology Group, Lund University, Lund, Sweden
    Immunology 137:172-82. 2012
  7. pmc S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3
    Saeid Ghavami
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, CancerCare Manitoba, Winnipeg, Canada
    Cell Res 20:314-31. 2010
  8. doi Expression and role of myeloid-related protein-14 in clinical and experimental sepsis
    Marieke A D van Zoelen
    Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 180:1098-106. 2009
  9. pmc RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
    Olga Turovskaya
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Carcinogenesis 29:2035-43. 2008
  10. pmc S100A9 mediates neutrophil adhesion to fibronectin through activation of beta2 integrins
    Nadia Anceriz
    Infectious Diseases Research Center, Laval University Hospital Center, Quebec, Canada G1V 4G2
    Biochem Biophys Res Commun 354:84-9. 2007

Detail Information

Publications217 found, 100 shown here

  1. ncbi S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity
    Wolfgang Nacken
    Institute of Experimental Dermatology, University of Munster, 48149 Munster, Germany
    Microsc Res Tech 60:569-80. 2003
    ..As unspecific phagocytes, they belong to the so-called innate immunity. Two S100 proteins, namely S100A9 (MRP14) and S100A8 (MRP8), constitute roughly 40% of the cytosolic protein in these cells, implying by their pure ..
  2. ncbi Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis
    K Odink
    Department of Biotechnology, Ciba Geigy, Basel, Switzerland
    Nature 330:80-2. 1987
    ..Characterization of MRP-8 and MRP-14 could therefore be useful to the understanding of cellular processes induced in chronic inflammation...
  3. ncbi S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells
    Alexander Hermani
    Research Group Hormones and Signal Transduction, German Cancer Research Centre, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Exp Cell Res 312:184-97. 2006
    ..Deregulated expression of S100 proteins, including S100A8 and S100A9, was reported in association with neoplastic disorders...
  4. ncbi Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion
    Carle Ryckman
    Infectious Diseases Research Center, Laval University Hospital Center, Sainte Foy, Quebec, Canada
    J Immunol 170:3233-42. 2003
    S100A8 and S100A9 are small calcium-binding proteins that are highly expressed in neutrophil and monocyte cytosol and are found at high levels in the extracellular milieu during inflammatory conditions...
  5. pmc S100A8 and S100A9: new insights into their roles in malignancy
    Geetha Srikrishna
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    J Innate Immun 4:31-40. 2012
    ..In this regard, damage-associated molecular pattern (DAMP) molecules such as S100A8 and S100A9, with well-known functions in inflammation, have been increasingly recognized not only as markers, but also as new ..
  6. pmc Induction of nuclear factor-κB responses by the S100A9 protein is Toll-like receptor-4-dependent
    Matteo Riva
    Immunology Group, Lund University, Lund, Sweden
    Immunology 137:172-82. 2012
    ..In this report, we investigated the capacity of lipopolysaccharide (LPS) -free S100A9 (DAMP) protein to activate human and mouse cells compared with lipoprotein-free LPS (PAMP)...
  7. pmc S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3
    Saeid Ghavami
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, CancerCare Manitoba, Winnipeg, Canada
    Cell Res 20:314-31. 2010
    ..Our data indicate that S100A8/A9-promoted cell death occurs through the cross-talk of mitochondria and lysosomes via ROS and the process involves BNIP3...
  8. doi Expression and role of myeloid-related protein-14 in clinical and experimental sepsis
    Marieke A D van Zoelen
    Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 180:1098-106. 2009
    Myeloid-related protein-8 (MRP8) and MRP14 can form heterodimers that elicit a variety of inflammatory responses...
  9. pmc RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
    Olga Turovskaya
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Carcinogenesis 29:2035-43. 2008
    ..In human colon tumor tissues and in a mouse model of CAC, we found that myeloid progenitors expressing S100A8 and S100A9 infiltrate regions of dysplasia and adenoma. mAbGB3...
  10. pmc S100A9 mediates neutrophil adhesion to fibronectin through activation of beta2 integrins
    Nadia Anceriz
    Infectious Diseases Research Center, Laval University Hospital Center, Quebec, Canada G1V 4G2
    Biochem Biophys Res Commun 354:84-9. 2007
    ..S100A8, S100A9, and S100A12 are small abundant proteins found in human neutrophil cytosol and presumed to be involved in ..
  11. doi Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism
    Jean Christophe Simard
    Laboratoire de recherche en inflammation et physiologie des granulocytes, Universite du Quebec, INRS Institut Armand Frappier, Laval, Quebec, Canada
    J Leukoc Biol 87:905-14. 2010
    b>S100A9 is a proinflammatory protein, expressed abundantly in the cytosol of neutrophils and monocytes...
  12. doi Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis
    Jean Christophe Simard
    Laboratoire de recherche en inflammation et physiologie des granulocytes, Universite du Quebec, Institut National de la Recherche Scientifique Institut Armand Frappier, Laval, Quebec City, Quebec H7V 1B7, Canada
    J Immunol 186:3622-31. 2011
    The damage-associated molecular-pattern S100A9 is found at inflammatory sites in infections and various autoimmune diseases...
  13. pmc Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes
    Thomas Vogl
    Institute of Immunology, University of Muenster, Röntgenstr 21, 48149 Muenster, Germany e mail
    Int J Mol Sci 13:2893-917. 2012
    S100A8 and S100A9 are EF-hand Ca(2+) binding proteins belonging to the S100 family...
  14. ncbi Fecal calprotectin: a quantitative marker of colonic inflammation in children with inflammatory bowel disease
    Ulrika Lorentzon Fagerberg
    Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    J Pediatr Gastroenterol Nutr 45:414-20. 2007
    ..Colorectal inflammation can be detected by increased excretion of fecal calprotectin (FC). The aim of this study was to evaluate FC as a quantitative marker of inflammatory activity in children with inflammatory bowel disease (IBD)...
  15. doi Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4
    Rik F P Schelbergen
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 64:1477-87. 2012
    S100A8 and S100A9 are two Ca(2+) binding proteins classified as damage-associated molecular patterns or alarmins that are found in high amounts in the synovial fluid of osteoarthritis (OA) patients...
  16. pmc Decreases in serum levels of S100A8/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritis
    Lucie Andrés Cerezo
    Institute of Rheumatology, First Medical Faculty, Charles University, Na Slupi 4, 128 50 Prague 2, Czech Republic
    Arthritis Res Ther 13:R122. 2011
    ..The aim of this study was to examine the serum levels of S100 proteins and to evaluate their role in patients with recent-onset rheumatoid arthritis (RA)...
  17. ncbi Analysis of the MRP8-MRP14 protein-protein interaction by the two-hybrid system suggests a prominent role of the C-terminal domain of S100 proteins in dimer formation
    C Propper
    Institute of Experimental Dermatology, Münster Medical School, Von Esmarch Strasse 56, D 48149 Munster, Germany
    J Biol Chem 274:183-8. 1999
    ..Using the two-hybrid system we analyzed the dimerization of MRP8 (S100A8) and MRP14 (S100A9), two S100 proteins expressed in myeloid cells...
  18. doi RAGE-dependent regulation of calcium-binding proteins S100A8 and S100A9 in human THP-1
    K Eggers
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Campus Mitte, Germany
    Exp Clin Endocrinol Diabetes 119:353-7. 2011
    ..we determined the effects of proinflammatory cytokines on RAGE-mediated induction of gene expression of S100A8 and S100A9. mRNA levels of S100A8 and S100A9 were upregulated following cytokine stimulation with IL-6 (1, 10, 100 ng/ml) ..
  19. pmc S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576 mice, AD animal model
    Tae Young Ha
    Department of Pharmacology, College of Medicine, National Creative Research Initiative Center for Alzheimer s Dementia and Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea
    PLoS ONE 5:e8840. 2010
    ..we performed microarray analysis with APP(V717I)-CT100 transgenic mice, an animal model of AD, and isolated the S100a9 gene, which encodes an inflammation-associated calcium binding protein...
  20. ncbi Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cations
    Thomas Vogl
    Institute of Experimental Dermatology, University of Muenster, Roentgenstrasse 21, 48149 Muenster, Germany
    Biochim Biophys Acta 1763:1298-306. 2006
    S100A8 and S100A9 are two proinflammatory molecules belonging to the S100 family of calcium-binding proteins...
  21. pmc S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway
    Saeid Ghavami
    Manitoba Institute of Cell Biology and Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada
    J Leukoc Biol 83:1484-92. 2008
    ..RAGE small interfering RNA pretreatment abrogated the S100A8/A9-induced NF-kappaB activation. Our data indicate that S100A8/A9-promoted cell growth occurs through RAGE signaling and activation of NF-kappaB...
  22. ncbi MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program
    Dorothee Viemann
    Institute of Experimental Dermatology, University of Munster, Germany
    Blood 109:2453-60. 2007
    Activated phagocytes express considerable amounts of MRP8 and MRP14, 2 calcium-binding S100 proteins forming stable heterodimers that are specifically secreted at inflammatory sites in many diseases...
  23. ncbi S100A8 and S100A9 in human arterial wall. Implications for atherogenesis
    Michelle M McCormick
    School of Medical Sciences, St Vincent s Hospital, University of New South Wales, Sydney, Australia
    J Biol Chem 280:41521-9. 2005
    Atherogenesis is a complex process involving inflammation. S100A8 and S100A9, the Ca2+-binding neutrophil cytosolic proteins, are associated with innate immunity and regulate processes leading to leukocyte adhesion and transmigration...
  24. ncbi S100A8 and S100A9 overexpression is associated with poor pathological parameters in invasive ductal carcinoma of the breast
    Kazumori Arai
    Department of Pathology, Shizuoka General Hospital, 4 27 1 Kitaando, Aoi ku, Shizuoka 420 0881, Japan
    Curr Cancer Drug Targets 8:243-52. 2008
    S100 protein A8 and A9 naturally form a stable heterocomplex. Recently, we have proved that S100A9 overexpression in various adenocarcinomas is associated with poor tumor differentiation...
  25. ncbi Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophils
    George Lominadze
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, KY 40202, USA
    J Immunol 174:7257-67. 2005
    ..Direct phosphorylation of the MRP-14/MRP-8 complex by p38 MAPK increased actin binding in vitro by 2-fold. These results indicate that MRP-14 is a potential mediator of p38 MAPK-dependent functional responses in human neutrophils...
  26. pmc Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activity
    Satoru Yui
    Faculty of Pharmaceutical Sciences, Teikyo University, Tsukui gun, Kanagawa, Japan
    Mediators Inflamm 11:165-72. 2002
    ..of 8 and 14 kDa subunits, which have also been termed migration inhibitory factor-related proteins MRP8 and MRP14. We previously reported that rat calprotectin purified from inflammatory neutrophils induces apoptosis of various ..
  27. ncbi S100A8/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytes
    Takamasa Nukui
    Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikatachou, Okayama 700 8558, Japan
    J Cell Biochem 104:453-64. 2008
    S100A8 and S100A9 are known to be up-regulated in hyperproliferative and psoriatic epidermis, but their function in epidermal keratinocytes remains largely unknown...
  28. ncbi Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions
    Saeid Ghavami
    Clinical Biochemistry Department, Faculty of Medical Sciences, Tarbiat Modaress University, P O BOX 14115 111, Tehran, I R, Iran
    J Leukoc Biol 76:169-75. 2004
    ....
  29. ncbi Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events
    Aileen M Healy
    Millennium Pharmaceuticals, Inc, Cambridge, MA, USA
    Circulation 113:2278-84. 2006
    ..Because platelets lack nuclear DNA but retain megakaryocyte-derived mRNAs, the platelet transcriptome provides a novel window on gene expression preceding acute coronary events...
  30. ncbi S100 proteins calprotectin and S100A12 are related to radiographic changes rather than disease activity in psoriatic arthritis with low disease activity
    Tor Magne Madland
    Section for Rheumatology, Institute of Medicine, University of Bergen, Bergen, Norway
    J Rheumatol 34:2089-92. 2007
    To investigate serum levels of calprotectin (S100A8/S100A9) and S100A12 as markers of disease activity or distinct clinical or radiographic features in patients with psoriatic arthritis (PsA).
  31. doi S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway
    Rui Wu
    Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P R China
    Int J Oncol 42:1001-10. 2013
    The S100A9 protein, a member of the S100 protein family, is often upregulated in various types of cancer, including hepatocellular carcinoma (HCC)...
  32. pmc Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosus
    Christian Lood
    Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Solvegatan 23, 223 62 Lund, Sweden
    Arthritis Res Ther 13:R60. 2011
    ..The heterodimer of the cytosolic calcium-binding proteins S100A8 and S100A9 (S100A8/A9) is secreted by activated polymorphonuclear neutrophils (PMNs) and monocytes and serves as a serum ..
  33. doi Prognostic impact of S100A9 overexpression in non-small cell lung cancer
    Hideki Kawai
    Department of Thoracic Surgery, Akita Red Cross Hospital, 222 1 Naeshirosawa, Saruta, Kamikitate, Akita, 010 1495, Japan
    Tumour Biol 32:641-6. 2011
    S100 proteins have been implicated in the progression and metastasis of several cancers. Among the S100 family, S100A9 is reportedly expressed in non-small cell lung cancer (NSCLC), though the clinical significance and prognostic value of ..
  34. doi Local calprotectin production in colorectal cancer and polyps--active neutrophil recruitment in carcinogenesis
    Kim Luley
    First Department of Medicine, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Int J Colorectal Dis 26:603-7. 2011
    ..Calprotection expression was correlated with neutrophil infiltration, markers of bacteremia, and systemic inflammation...
  35. ncbi S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2
    Saeid Ghavami
    Manitoba Institute of Cell Biology, Canada
    Biochim Biophys Acta 1783:297-311. 2008
    ..Together, these data indicate that S100A8/A9-induced cell death involves Bak, selective release of Smac/DIABLO and Omi/HtrA2 from mitochondria, and modulation of the balance between pro- and anti-apoptotic proteins...
  36. pmc S100A8/A9 activate key genes and pathways in colon tumor progression
    Mie Ichikawa
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, 10905 Road to the Cure, San Diego, CA 92121, USA
    Mol Cancer Res 9:133-48. 2011
    ..Mice lacking S100A9 showed significantly reduced tumor incidence, growth and metastasis, reduced chemokine levels, and reduced ..
  37. ncbi Transendothelial migration of 27E10+ human monocytes
    I Eue
    Institute of Experimental Dermatology, University of Munster, Von Esmarch Strasse 56, 48149 Munster, Germany
    Int Immunol 12:1593-604. 2000
    The myeloid-related proteins MRP8 (S100A8) and MRP14 (S100A9), two members of the S100 family of calcium-binding proteins, are co-expressed and form a cell-surface and cytoskeleton-associated heterodimer upon calcium mobilization which is ..
  38. ncbi Serum and mucosal S100 proteins, calprotectin (S100A8/S100A9) and S100A12, are elevated at diagnosis in children with inflammatory bowel disease
    Steven T Leach
    School of Women s and Children s Health, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    Scand J Gastroenterol 42:1321-31. 2007
    ..The objective of this study was to assess serum and mucosal levels of calprotectin, S100A12 and soluble receptor for advanced glycation end products (sRAGE), a putative S100 ligand, in a paediatric population with IBD...
  39. ncbi Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells
    Dorothee Viemann
    Institute of Experimental Dermatology, Integrated Functional Genomics, and the Interdisciplinary Clinical Research Center, University Hospital Muenster, University of Muenster, Röntgenstrasse 21, 48149 Muenster, Germany
    Blood 105:2955-62. 2005
    Myeloid-related protein 8 (MRP8) and MRP14, S100 proteins secreted by activated phagocytes, bind specifically to endothelial cells. The endothelial response to MRP8/MRP14, however, is unknown...
  40. doi S100A8/A9 induces apoptosis and inhibits metastasis of CasKi human cervical cancer cells
    Fengjin Qin
    Gynaecology and Obstetrics Department, Peking University Third Hospital, Beijing, People s Republic of China
    Pathol Oncol Res 16:353-60. 2010
    ..Deregulated expression of S100 proteins, including S100A9 and its partner S100A8, was reported to be associated with neoplastic disorders...
  41. doi Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent
    Matteo Bianchi
    Division of Immunology Hematology BMT, University Children s Hospital Zurich, Zurich, Switzerland
    J Allergy Clin Immunol 127:1243-52.e7. 2011
    ..This process is defective in chronic granulomatous disease (CGD) because of impaired phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase function...
  42. doi Phagocyte-specific S100A8/A9 protein levels during disease exacerbations and infections in systemic lupus erythematosus
    Muhammad S Soyfoo
    Department of Rheumatology, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070, Bruxelles, Belgium
    J Rheumatol 36:2190-4. 2009
    S100A8 and S100A9 are calcium binding proteins of the S100 family highly expressed in neutrophils and monocytes. S100 proteins are novel ligands of TLR4 important in modulating inflammation...
  43. ncbi Myeloid related protein-8/14 stimulates interleukin-8 production in airway epithelial cells
    Ali Ahmad
    Respiratory Research Laboratory, Department of Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Am J Respir Cell Mol Biol 29:523-30. 2003
    ....
  44. ncbi Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer
    Alexander Hermani
    Research Group Hormones and Signal Transduction, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:5146-52. 2005
    ..We examined the expression of two members of this family, S100A8 and S100A9, together with the S100 receptor RAGE (receptor for advanced glycation end products) in human prostate ..
  45. doi The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis
    Michael Frosch
    University of Muenster, Muenster, Germany
    Arthritis Rheum 60:883-91. 2009
    ..We undertook this study to analyze the relevance of myeloid-related proteins (MRPs) 8 and 14, endogenous activators of Toll-like receptor 4, in diagnosis and pathogenesis of systemic-onset JIA...
  46. ncbi Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)
    C Kerkhoff
    Institut für Experimentelle Dermatologie, Munster, Germany
    Biochim Biophys Acta 1448:200-11. 1998
    The two migration inhibitory factor- (MIF)-related protein-8 (MRP8; S100A8) and MRP14 (S100A9) are two calcium-binding proteins of the S100 family...
  47. ncbi Up-regulation of metastasis-promoting S100A4 (Mts-1) in rheumatoid arthritis: putative involvement in the pathogenesis of rheumatoid arthritis
    Jorg Klingelhofer
    Danish Cancer Society, Copenhagen, Denmark
    Arthritis Rheum 56:779-89. 2007
    ..To examine the involvement of the metastasis-inducing protein S100A4 (Mts-1) in the pathogenesis of rheumatoid arthritis (RA)...
  48. ncbi The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils
    R A Newton
    Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    J Immunol 160:1427-35. 1998
    ..protein (MRP-14) and its heterodimeric partner, MRP-8, are members of the S100 family of calcium-binding proteins (S100A9 and S100A8, respectively)...
  49. ncbi Expression of myeloid-related protein-8 and -14 in patients with acute Kawasaki disease
    Keiich Hirono
    Department of Pediatrics, Toyama University, Toyama, Japan
    J Am Coll Cardiol 48:1257-64. 2006
    ..This study investigated patients with acute Kawasaki disease (KD) to validate myeloid-related protein (MRP)-8/MRP-14 as a marker of disease activity and severity of coronary artery lesion development...
  50. pmc The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis
    Katsue Sunahori
    Department of Medicine and Clinical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Arthritis Res Ther 8:R69. 2006
    S100A8 and S100A9, two Ca2+-binding proteins of the S100 family, are secreted as a heterodimeric complex (S100A8/A9) from neutrophils and monocytes/macrophages...
  51. pmc Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate
    Kiran Yanamandra
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    PLoS ONE 4:e5562. 2009
    ..We report here that amyloid formation is linked to another major age-related phenomenon--prostate tissue remodelling in middle-aged and elderly men...
  52. pmc Calprotectin S100A9 calcium-binding loops I and II are essential for keratinocyte resistance to bacterial invasion
    Chantrakorn Champaiboon
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 284:7078-90. 2009
    Epithelial cells expressing calprotectin, a heterodimer of S100A8 and S100A9 proteins, are more resistant to bacterial invasion...
  53. ncbi MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner
    J Roth
    Institute of Experimental Dermatology, University of Munster, Germany
    Blood 82:1875-83. 1993
    MRP8 and MRP14 are two Ca(2+)-binding proteins of the S-100 family expressed by myelomonocytic cells. Both proteins assemble to noncovalently associated complexes in a Ca(2+)-dependent manner...
  54. ncbi The S100 family of EF-hand calcium-binding proteins: functions and pathology
    B W Schafer
    Department of Pediatrics, University of Zurich, Switzerland
    Trends Biochem Sci 21:134-40. 1996
    ..Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging...
  55. doi S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis
    Julia Nemeth
    Division of Signal Transduction and Growth Control A100, German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Heidelberg, Germany
    Hepatology 50:1251-62. 2009
    ..HCC) revealed a comprehensive list of known and novel putative NF-kappaB target genes, including S100a8 and S100a9. We detected increased co-expression of S100A8 and S100A9 proteins in mouse HCC cells, in human HCC tissue, and in ..
  56. ncbi The crystal structure of human MRP14 (S100A9), a Ca(2+)-dependent regulator protein in inflammatory process
    Hiroshi Itou
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060 0810, Japan
    J Mol Biol 316:265-76. 2002
    Human MRP14 (hMRP14) is a Ca(2+)-binding protein from the S100 family of proteins...
  57. pmc Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathway
    Mizhir Atallah
    The Laboratory for Cellular and Molecular Immunology, Department of Medicine, Hadassah Hebrew University Medical Center Jerusalem, Jerusalem, Israel
    PLoS ONE 7:e29333. 2012
    ..This mechanism is suggested to have a fine-tuning role in regulating the neutrophil number in bone marrow, peripheral blood, and inflammatory sites...
  58. doi Global gene expression profiling unveils S100A8/A9 as candidate markers in H-ras-mediated human breast epithelial cell invasion
    Aree Moon
    College of Pharmacy, Duksung Women s University, Seoul, Korea
    Mol Cancer Res 6:1544-53. 2008
    ..We then tested whether S100A8 and S100A9, two of the genes which are most highly up-regulated in an H-Ras-specific manner, play a causative role for H-Ras-..
  59. ncbi Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family
    B W Schafer
    University of Zurich, Department of Pediatrics, Switzerland
    Genomics 25:638-43. 1995
    ..The new nomenclature should facilitate and further the understanding of this protein family and be easily expandable to other species...
  60. ncbi HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes
    Carle Ryckman
    Centre de Recherche en Infectiologie, Pavillon Centre Hospitalier de l Université Laval, Centre Hospitalier Universitaire de Quebec, and Département de Biologie Médicale, Faculte de Medecine, Universite Laval, Quebec, Canada
    J Immunol 169:3307-13. 2002
    S100A8, S100A9, and S100A12, collectively known as myeloid-related proteins (MRPs), are highly expressed by the myeloid cell lineage and are found in the extracellular milieu during infections and inflammatory conditions...
  61. pmc Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis
    Yueh Sheng Chen
    Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia
    Arthritis Res Ther 11:R39. 2009
    ..This study evaluated the serum levels of S100A9, S100A8, S100A12 and sRAGE in RA patients, to determine their relationship to inflammation and joint and vascular ..
  62. ncbi S100 proteins in Corpora amylacea from normal human brain
    D Hoyaux
    Laboratory of Histopathology, Erasmus University Hospital, Faculty of Medicine, Université Libre de Bruxelles CP 620, 808 Route de Lennik, 1070, Brussels, Belgium
    Brain Res 867:280-8. 2000
    ..the presence of different S100 proteins (S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A8, S100A9, S100A12 and S100B) in C.A. from normal human brain...
  63. pmc Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy
    Klaus Burkhardt
    Nephrological Clinic Weissenburg, 91781 Weissenburg, Germany
    Cardiovasc Diabetol 8:10. 2009
    ..We investigated whether myeloid-related protein 8/14 complex (MRP8/14) secreted by transmigrating monocytes and granulocytes may represent a biomarker for microvascular alterations in patients with type 2 diabetes and nephropathy...
  64. pmc Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation
    E Lagasse
    Department of Biotechnology, Ciba Geigy, Basel, Switzerland
    Mol Cell Biol 8:2402-10. 1988
    ..Two proteins, MRP8 and MRP14, which are expressed in infiltrate macrophages during inflammatory reactions but not in normal tissue macrophages, ..
  65. ncbi Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis
    Michael Frosch
    Institute of Experimental Dermatology and Department of Pediatrics, University of Munster, Munster, Germany
    Arthritis Rheum 48:2622-6. 2003
    ....
  66. ncbi TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins
    Pooja Pungaliya
    Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08901, USA
    J Proteome Res 6:3918-23. 2007
    ..Transfection studies confirmed mammalian Sin3A as a sumoylation substrate for TOPORS. These findings suggest that TOPORS may function as a tumor suppressor by regulating mSin3A and other proteins involved in chromatin modification...
  67. ncbi Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin
    Gerben Bouma
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Diabetes 53:1979-86. 2004
    ....
  68. ncbi Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease
    C E Shepherd
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney 2031, Australia
    Neurobiol Aging 27:1554-63. 2006
    ..S100A8, S100A9 and S100A12 comprise a new group of inflammation-associated proteins that are constitutively expressed by ..
  69. pmc Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products
    Philipp Ehlermann
    Universitat Heidelberg, Abteilung Innere Medizin III, Heidelberg, Germany
    Cardiovasc Diabetol 5:6. 2006
    ..As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression.
  70. ncbi Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity
    Nadja Leukert
    Institute of Experimental Dermatology, University of Muenster, Roentgenstr 21, 48149 Muenster, Germany
    J Mol Biol 359:961-72. 2006
    ..The heterodimers of S100A8 and S100A9 represent the major calcium-binding proteins in phagocytes...
  71. ncbi The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophils
    C Kerkhoff
    Institut für Experimentelle Dermatologie, 48149 Munster, Germany
    J Biol Chem 274:32672-9. 1999
    Recently, we identified the two myeloid related protein-8 (MRP8) (S100A8) and MRP14 (S100A9) as fatty acid-binding proteins (Klempt, M., Melkonyan, H., Nacken, W., Wiesmann, D., Holtkemper, U., and Sorg, C. (1997) FEBS Lett. 408, 81-84)...
  72. ncbi S100A8, S100A9 and the S100A8/A9 heterodimer complex specifically bind to human endothelial cells: identification and characterization of ligands for the myeloid-related proteins S100A9 and S100A8/A9 on human dermal microvascular endothelial cell line-1 c
    Ines Eue
    PAN Clinic, Zeppelinstrasse 1, 50667 Köln, Germany
    Int Immunol 14:287-97. 2002
    ..We demonstrate that S100A8, S100A9 and the S100A8/A9 heterodimeric complex bind to human dermal microvascular endothelial cell line (HMEC)-1 with an ..
  73. ncbi Loss of myeloid-related proteins 8 and myeloid-related proteins 14 expression in human esophageal squamous cell carcinoma correlates with poor differentiation
    Jian Ping Kong
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    World J Gastroenterol 10:1093-7. 2004
    ..proteins(MRP)8 and myeloid-related proteins(MRP)14 in human esophageal squamous cell carcinoma and to investigate if there was any correlation between MRP8 and MRP14 expression level and histopathological grade in these tumors.
  74. ncbi Expression of MRP14 gene is frequently down-regulated in Chinese human esophageal cancer
    Jie Wang
    National Laboratory of Molecular Oncology, Cancer Institute Hospital, Chinese Academy of Medical Sciences, Peking University of Medical School, Beijing 100021, China
    Cell Res 14:46-53. 2004
    Migration inhibitory factor-related protein 14 (MRP14) is one of calcium-binding proteins, referred as S100A9. The heterodimeric molecule formed by MRP14 with its partner MRP8 (S100A8) is the major fatty acid carrier in neutrophils...
  75. ncbi The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2
    Claus Kerkhoff
    Institute of Experimental Dermatology, University of Munster, Germany
    FASEB J 19:467-9. 2005
    ..its functional relevance by the impaired oxidase activity in neutrophil-like NB4 cells, after specific blockage of S100A9 expression, and bone marrow polymorphonuclear neutrophils from S100A9-/- mice...
  76. ncbi Up-regulation of the expression of S100A8 and S100A9 in lung adenocarcinoma and its correlation with inflammation and other clinical features
    Yan Jun Su
    Lung Cancer Department, Tianjin Lung Cancer Center, Tianjin Cancer Hospital and Institute, Tianjin 300060, China
    Chin Med J (Engl) 123:2215-20. 2010
    S100A8 and S100A9 are two members of the S100 protein family characterized by the presence of two Ca2+-binding sites of the EF-hand type...
  77. doi Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation
    Andreas Voss
    Institute of Immunology, University of Muenster, Muenster, Germany
    FEBS Lett 585:440-6. 2011
    ..S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair...
  78. ncbi Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14
    J Edgeworth
    Macrophage Laboratory, Lincoln s Inn Fields, UK
    Nature 342:189-92. 1989
    ..are variously referred to as the cystic fibrosis antigen, the L1 light chain, MRP-8 or p8, and the L1 heavy chain, MRP14 or p14, respectively...
  79. ncbi The hetero-oligomeric complex of the S100A8/S100A9 protein is extremely protease resistant
    Wolfgang Nacken
    Institute for Experimental Dermatology, University of Muenster, Roentgenstrasse 21, 48149 Muenster, Germany
    FEBS Lett 581:5127-30. 2007
    S100A8, S100A9 and S100A12 proteins are associated with inflammation and tissue remodelling, both processes known to be associated with high protease activity...
  80. ncbi Binding of two nuclear complexes to a novel regulatory element within the human S100A9 promoter drives the S100A9 gene expression
    Claus Kerkhoff
    Institute of Experimental Dermatology, 48149 Muenster, Germany
    J Biol Chem 277:41879-87. 2002
    b>S100A9, also referred to as MRP14, is a calcium-binding protein whose expression is tightly regulated during differentiation of myeloid cells...
  81. pmc Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression
    Jens Grote
    Institute of Experimental Dermatology, University of Muenster, Germany
    BMC Mol Biol 7:48. 2006
    ..Dysregulated expression of S100 proteins, including S100A9, has been reported in the epidermis as a response to stress and in association with neoplastic disorders...
  82. ncbi Biochemical characterization of the murine S100A9 (MRP14) protein suggests that it is functionally equivalent to its human counterpart despite its low degree of sequence homology
    W Nacken
    Institute of Experimental Dermatology, University of Munster, Germany
    Eur J Biochem 267:560-5. 2000
    Due to the low degree of sequence similarity it has been speculated that murine and human S100A9 (MRP14), an inflammatory marker protein belonging to the S100 protein family, may have different cellular functions in mouse and man...
  83. pmc S100A8 and S100A9 in experimental osteoarthritis
    Hala Zreiqat
    Tissue Engineering and Biomaterials Research Unit, School of AMME J07, Faculty of Engineering, Bosch Institute, University of Sydney, Corner of Shepherd and Cleavland Street, New South Wales 2006, Australia
    Arthritis Res Ther 12:R16. 2010
    The objective was to evaluate the changes in S100A8 S100A9, and their complex (S100A8/S100A9) in cartilage during the onset of osteoarthritis (OA) as opposed to inflammatory arthritis.
  84. pmc Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro
    Marie Pierre Manitz
    Institute of Experimental Dermatology, Zentrum fur Molekularbiologie der Entzundung, Univeristy of Münster, 48149 Munster, Germany
    Mol Cell Biol 23:1034-43. 2003
    The S100A9 (MRP14) protein is abundantly expressed in myeloid cells and has been associated with various inflammatory diseases. The S100A9-deficient mice described here were viable, fertile, and generally of healthy appearance...
  85. ncbi Immunohistochemical investigation of S100A9 expression in pulmonary adenocarcinoma: S100A9 expression is associated with tumor differentiation
    K Arai
    Department of Pathology, Shizuoka General Hospital, Shizuoka 420 0881, Japan
    Oncol Rep 8:591-6. 2001
    ..However, there have been few studies on S100A9 in specific types of carcinomas, except for squamous cell carcinoma (SCC) because the expression in normal ..
  86. pmc An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine
    T Lewis
    Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Greenport, New York 11944 0848, USA
    J Virol 74:1275-85. 2000
    ..Time course analysis and viral DNA synthesis inhibitor experiments indicated that p14 was a late viral protein...
  87. ncbi Immunopathogenic mechanisms in hypertension
    N Lefkos
    Cardiology Unit, Aristotle University of Thessaloniki, Hippokration Hospital, Greece
    Am J Hypertens 8:1141-5. 1995
    ..immunity against arterial wall antigen was studied in all subjects by means of migration inhibitory factor (MIF) against relevant antigen preparation...
  88. pmc Vascular actions of thrombin receptor-derived polypeptides: structure-activity profiles for contractile and relaxant effects in rat aorta
    A A Laniyonu
    Department of Pharmacology and Therapeutics, University of Calgary, Faculty of Medicine, AB Canada
    Br J Pharmacol 114:1680-6. 1995
    ..Rat P5-NH2), SFLLRNP (P7), SFLLRNP-NH2 (P7-NH2), SFFLRNP (Rat P7), SFFLRNP-NH2 (Rat P7-NH2), and SFLLRNPNDKYEPF (P14). 2...
  89. ncbi Granulomatous slack skin in childhood
    F M Camacho
    Department of Medical-Surgical Dermatology, Hospital Universitario Virgen Macarena, Universidad de Sevilla, Spain
    Pediatr Dermatol 14:204-8. 1997
    ..The phenotype of the giant cells was lysozyme positive, CD68+ and Mac387-...
  90. ncbi Side effects of antibiotics on immune response parameters and their possible implications in antimicrobial chemotherapy
    G Gillissen
    Institute of Medical Microbiology, Medical Faculty, , Aachen
    Zentralbl Bakteriol Mikrobiol Hyg A 270:171-99. 1988
    ..g. foodpad swelling reaction, MIF-production, mitogen/antigen induced lymphocyte proliferation and delayed type hypersensitivity skin reaction), on ..
  91. ncbi The monocyte/macrophage infiltrate in 35 medulloblastomas: a paraffin-wax study
    M L Rossi
    Department of Neuropathology, Midland Centre for Neurosurgery and Neurology, Birmingham, United Kingdom
    Tumori 77:36-40. 1991
    ..tissue from 35 medulloblastomas, collected over 23 years (27 non-desmoplastic and 8 desmoplastic) with KP1 and Mac387 two monoclonal anti-monocytes/macrophage (M/Ms) antibodies recommended for use on paraffin wax embedded tissue...
  92. ncbi Effect of vitamin E on production of macrophage migration inhibitory factor (MIF) by macrophages
    W Sakamoto
    Department of Biochemistry, School of Dentistry, Hokkaido University, Sapporo, Japan
    Biofactors 10:139-43. 1999
    Macrophage migration inhibitory factor (MIF), a putative cytokine involved in inflammatory and immune responses, was identified in rat peritoneal macrophages by Western blot analysis and its secretion into culture medium by enzyme-linked ..
  93. ncbi [Studies on transference of hydrogenase genes of Rhizobium arachis]
    Z Wang
    Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
    Wei Sheng Wu Xue Bao 41:421-6. 2001
    The hydrogen-uptake genes were transferred into wild Rhizobium arachis Ra strains (Hup-, Nif+, Apr) by triparental mating using pRK2013 as help plasmid. A transconjugant R...
  94. ncbi A heterocomplex formed by the calcium-binding proteins MRP8 (S100A8) and MRP14 (S100A9) binds unsaturated fatty acids with high affinity
    G Siegenthaler
    Clinique de Dermatologie, Hopital Cantonal Universitaire, CH 1211 Geneve 14, Switzerland
    J Biol Chem 272:9371-7. 1997
    ..by the non-covalent association of two calcium-binding proteins of the S100 family: MRP8 (S100A8) and MRP14 (S100A9). Fatty acid-competition studies on the [3H]oleic acid...
  95. ncbi [A case of fulminant psittacosis necessitating mechanical ventilation diagnosed by chlamydial isolation form BALF]
    H Taniguchi
    Third Department of Internal Medicine, Miyazaki Medical College, Japan
    Kansenshogaku Zasshi 69:1396-401. 1995
    ..diagnosis was established with a significant rise of both IgG and IgM antibody against Chlamydia psittaci with MIF and identification of Chlamydia with the cell culture method...
  96. ncbi Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cells
    Tadamichi Shimizu
    Departments of Dermatology and Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Biol Chem 279:13729-37. 2004
    Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has been shown to play a role in wound-healing processes...
  97. doi Association of interindividual differences in p14ARF promoter methylation with single nucleotide polymorphism in primary colorectal cancer
    Mi Yeon Kang
    Center for Genome Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Kangnam Ku, Seoul, South Korea
    Cancer 112:1699-707. 2008
    ..The objective of the current study was to understand whether single nucleotide polymorphisms (SNPs) around the promoter of a gene are implicated in the interindividual differences of CpG island hypermethylation...
  98. ncbi Long-term effect of nifedipine and hydrochlorothiazide on blood pressure and sodium homeostasis at varying levels of salt intake in mildly hypertensive patients
    F C Luft
    Department of Internal Medicine-Nephrology, , Germany
    Am J Hypertens 4:752-60. 1991
    To elucidate and compare the effects of nifedipine (NIF) and hydrochlorothiazide (HCTZ) on blood pressure (BP) and sodium (Na) balance, we conducted a randomized, double-blind, crossover study with 50 mg/day HCTZ and 90 mg/day NIF (as ..
  99. ncbi [Spontaneous cure of pneumonia caused by Chlamydia pneumoniae]
    N Miyashita
    Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 69:934-9. 1995
    ..512-fold in the acute phase and decreased to 32-fold in the convalescent phase using the micro-immunofluorescence (MIF) test, indicating a C. pneumoniae acute infection. In fact, no other micro-organisms were detected...
  100. pmc Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infection
    Christian Østergaard
    Department of Clinical Microbiology, Copenhagen University Hospital Herlev, Herlev Ringvej, DK 2730 Herlev, Denmark
    Crit Care 13:R101. 2009
    Macrophage migration inhibitory factor (MIF) plays an essential pathophysiological role in septic shock, but its role in central nervous system infection (CNS) remains to be defined.
  101. ncbi Xefiltin, a new low molecular weight neuronal intermediate filament protein of Xenopus laevis, shares sequence features with goldfish gefiltin and mammalian alpha-internexin and differs in expression from XNIF and NF-L
    Y Zhao
    Department of Biological Sciences, University at Albany, State University of New York 12222, USA
    J Comp Neurol 377:351-64. 1997
    ..mammals, the progressive maturation of neurons is marked by successive changes in neuronal intermediate filament (nIF) subunit composition...

Research Grants68

  1. Genetic and Inflammatory Factors in Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2010
    ..inflammation has also been linked with polymorphisms affecting levels of macrophage migration inhibitory factor (MIF) gene, which induces TNF...
  2. LPA receptor signaling in colonic epithelia
    CHANGHYON CHRIS YUN; Fiscal Year: 2013
    ..cyclin D, hypoxia-inducible factor (HIF)-1?, HIF-2?, cyclooxygenase-2, and macrophage migration inhibitory factor (MIF)...
  3. Trichomonas vaginalis MIF: a role in prostate cancer and infertility?
    PATRICIA JEAN JOHNSON; Fiscal Year: 2013
    ..vaginalis homologue of the inflammatory cytokine, human macrophage migration inhibitory factor (MIF). Increased level of human MIF (HuMIF) have been found in both prostate cancer and the semen of infertile men...
  4. Chemopreventition and treatment of non-melanoma skin cancer by targeting MIF
    Abhay R Satoskar; Fiscal Year: 2013
    ..Macrophage migration inhibitory factor (MIF) is a pleiotropi cytokine which is produced by variety of cells, including activated macrophages and neutrophils...
  5. Therapeutic Application of Small Molecule MIF Inhibitors in Rheumatoid Arthritis
    Yoonsang Cho; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Macrophage migration inhibitory factor (MIF) plays an important role for the recruitment of innate and adaptive immune cells to the place of inflammation...
  6. MIF in progression and treatment of ALD
    Laura E Nagy; Fiscal Year: 2013
    ..a pre- clinical mouse model of chronic ethanol exposure, we have identified macrophage migration inhibitory factor (MIF) as an important contributor to ethanol-induced steatosis and inflammation...
  7. Innate and Adaptive Immune Mechanisms in Arthritis
    RICHARD J BUCALA; Fiscal Year: 2013
    ..Since our initial cloning of murine macrophage migration inhibitory factor (MIF), we have focused on the role of this mediator in the pathogenesis of rheumatoid arthritis...
  8. Immunoregulation of Myelin Specific T Lymphocytes
    Arthur A Vandenbark; Fiscal Year: 2013
    ..on the monocyte cell surface and blocking the inflammatory effects of macrophage migration inhibitory factor (MIF) that is a key pathogenic cytokine for EAE and MS...
  9. Regulation of Hypoxic Pulmonary Hypertension by MIF
    Todd M Kolb; Fiscal Year: 2012
    ..The pluripotential cytokine MIF (macrophage migration inhibitory factor) has described roles in regulating changes in cardiomyocyte glucose ..
  10. The role of HIF2alpha in colon carcinogenesis
    Yatrik M Shah; Fiscal Year: 2013
    ..3) The proinflammatory mediators, macrophage migration inhibitory factor (MIF) and prostaglandin E2 (PGE2) are early initiating factors in HIF2a-induced colon inflammation...
  11. MIF: a pro-inflammatory cytokine as a novel target to reduce bladder inflammation
    Pedro L Vera; Fiscal Year: 2013
    ..applicant): Experimental evidence supports the pro-inflammatory effect of Macrophage Migration Inhibitory Factor (MIF) in bladder inflammation, but how MIF mediates bladder inflammation is poorly understood...
  12. Novel treatment strategies to regulate inflammation during P.aeruginosa keratitis
    MIHAELA GUEORGUIEVA GADJEVA; Fiscal Year: 2013
    ..studies conducted during my current R21 funding period which showed that macrophage migration inhibitory factor (MIF) has an unappreciated importance in regulating innate immune responses to P...
  13. The Role of Macrophage Migration Inhibitory Factor in Osteoarthritis
    MEREDITH A GREENE; Fiscal Year: 2013
    ..Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that has been studied for its role in the immune system and in autoimmune diseases ..
  14. Amplification of tumor hypoxic responses by MIF-dependent HIF stabilization
    Robert A Mitchell; Fiscal Year: 2013
    ..We recently discovered that macrophage migration inhibitory factor (MIF), one of the oldest cytokines ever described, is elevated in PDAC patient's plasma and induced by hypoxia-..
  15. MIF AND THE HOST RESPONSE TO INFECTION
    RICHARD J BUCALA; Fiscal Year: 2013
    ..In 1993, we cloned murine macrophage migration inhibitory factor (MIF) as an upstream regulator of innate immunity and mediator of lethal shock...
  16. AMP-activated protein kinase in the ischemic heart
    Lawrence H Young; Fiscal Year: 2012
    ..paradigm for AMPK activation, based on our discovery that the cytokine macrophage migration inhibitory factor (MIF) has an autocrine/paracrine effect to amplify AMPK activation during ischemia...
  17. Role of Macrophage Migration Inhibitory Factor (MIF) in Pneumococcal Pathogenesis
    Rituparna Das; Fiscal Year: 2013
    ..My preliminary data demonstrate an important role for macrophage migration inhibitory factor (MIF), a cytokine and upstream mediator of the innate immune response, in pneumococcal infection...
  18. Paraventricular nucleus regulatory mechanisms in stress and hypertension
    Colin Sumners; Fiscal Year: 2013
    ..We have recently identified macrophage migration inhibitory factor (MIF) as an intracellular negative regulator of the excitatory actions of Ang II in normotensive rat neurons...
  19. MIF-Thyroxine Interactions in the Pathogenesis of Pulmonary Arterial Hypertension
    Edmund J Miller; Fiscal Year: 2013
    ..clinically relevant interaction between a proinflammatory cytokine [Macrophage Migration Inhibitory Factor (MIF)] and a thyroid hormone [Thyroxine (T4)] in PAH...
  20. Safe and Efficacious Oral MIF Inhibitors for Rheumatoid Arthritis Treatment
    ANDERSON GAWECO; Fiscal Year: 2012
    ..Selective inhibition of macrophage migration inhibitory factor [MIF] has been target validated demonstrating unprecedented superior safety and efficacy in preclinical RA and several ..
  21. Molecular characterization of a hookworm Macrophage Migration Inhibitory Factor
    Jon J Vermeire; Fiscal Year: 2010
    ..We have identified an orthologue of the inflammatory mammalian cytokine macrophage migration inhibitory factor (MIF) from the human hookworm Ancylostoma ceylanicum...
  22. Developing Small MIF Inhibitors for Rheumatoid Arthritis
    Christian Grant; Fiscal Year: 2013
    ..academic partner (The Feinstein Institute for Medical Research), targets macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine whose dysregulation underlies many autoimmune diseases...
  23. Role of Macrophage Migration Inhibitory Factor in Osteoclastogenesis
    Sun Kyeong Lee; Fiscal Year: 2013
    ..by applicant): The goal of this proposal is to examine the role of macrophage migration inhibitory factor (MIF) in the regulation of osteoclastogenesis...
  24. MIF: A novel CNS regulator of cardiovascular function
    Colin Sumners; Fiscal Year: 2013
    ..We established previously that in normal rats MIF is an Ang II-inducible intracellular negative regulator of the AT1R mediated excitation of PVN to RVLM sympathetic ..
  25. Orchestration of breast cancer osteolytic bone metastasis by MIF
    Jessica M Grunda; Fiscal Year: 2013
    ..metastasis generated by our laboratory as a 'discovery tool', macrophage migration inhibitory factor (MIF) was identified as a factor potentially orchestrating the development of breast cancer osteolytic bone metastasis ..
  26. The Role of MIF in Osteoarthritis
    Richard F Loeser; Fiscal Year: 2013
    ..exploratory and developmental (R21) project is to determine the role of macrophage migration inhibitory factor (MIF) in the development of osteoarthritis (OA) in mice and obtain data on MIF function in human joint tissues...
  27. Molecular Recognition of Proteins and Ligand Design
    William L Jorgensen; Fiscal Year: 2013
    ..biomolecular targets are addressed: HIV-1 reverse transcriptase (HIV-RT), macrophage migration inhibitory factor (MIF), and tyrosyl-DNA phosphodiesterase 1 (Tdp1)...
  28. Regulators of Endothelial Cell Apoptosis in LPS-Induced Acute Lung Injury
    Rachel L Damico; Fiscal Year: 2012
    ..Further, her work demonstrates that macrophage migration inhibitory factor (MIF) is a determinant of EC responses to LPS...
  29. Development of Ibudilast as a Novel Treatment for Alcoholism
    Lara Ray; Fiscal Year: 2013
    ..glial cell modulator that inhibits phosphodiesterases (PDE) -4 and -10 and macrophage migration inhibitory factor (MIF)...
  30. Therapeutic Inhibition of MIF in Rheumatoid Arthritis
    KAREN G ANTHONY; Fiscal Year: 2013
    ..the inflammatory response triggered by the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF)...
  31. The Lung as a Source of Inflammation in Sepsis
    Edmund Miller; Fiscal Year: 2009
    ..Macrophage migration inhibitory factor (MIF), an important mediator in sepsis, has been shown recently to be a cardiac depressant factor, and to play a ..
  32. Release of MIF protein complexes in vivo: response to inflammation
    PEDRO VERA; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Macrophage migration inhibitory factor (MIF), is a pro-inflammatory cytokine produced by the urothelium...
  33. Therapeutic Inhibition of MIF in Rheumatoid Arthritis
    Karen Anthony; Fiscal Year: 2009
    ..RA), which will act by reducing the inflammatory response triggered by macrophage migration inhibitory factor (MIF). RA afflicts up to 4 million people in the U.S...
  34. Potential Role of H. Pylori-induced MIF in Gastric Cancer
    ELLEN BESWICK; Fiscal Year: 2009
    ..H. pylori induces macrophage migration inhibitory factor (MIF) production from gastric epithelial cells, and MIF production is an important factor in many cancers...
  35. HEMOZOIN AND MALARIA PATHOGENESIS
    JAMES MARTINEY; Fiscal Year: 1999
    ..We have preliminary data demonstrating the release of large amounts of macrophage migration inhibitory factor (MIF) by macrophages after ingestion of hemozoin or parasitized erythrocytes...
  36. GIF regulation of B cells and CD4 cells
    Katsuji Sugie; Fiscal Year: 2003
    ..the genome and its nucleotide sequence is identical is that published for macrophage migration inhibitory factor (MIF). MIF(GIF)-/- mice show enhanced susceptibility to Leishmania major...
  37. MACROPHAGE PROLIFERATION AND ACTIVATION
    John Hadden; Fiscal Year: 1980
    ..Sephadex chromatography indicates an approximate molecular weight similar to that of migration inhibitory factor (MIF); however, vacuum dialysis prior to chromatography removes MIF and, therefore, distinguishes between the two ..
  38. Cytokine-HPA Interactions During Pregnanacy
    Bradley Pearce; Fiscal Year: 2006
    ..Macrophage migration inhibitory factor (MIF) is an immunohormonal molecule that overrides the effect of cortisol on the GR...
  39. Neurobiology of MIF in development and disease
    Bradley Pearce; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Macrophage migration inhibitory factor (MIF) is a unique molecule that functions as a cytokine and a hormone, and is induced by infections and psychological stress in animal models...
  40. The role of MIF in hookworm infection and disease
    Michael Cappello; Fiscal Year: 2009
    ..A eDNA corresponding to a homologue of the mammalian cytokine Macrophage Migration Inhibitory Factor (MIF) has recently been cloned from the human hookworm Ancylostoma ceylanicum...
  41. MOLECULES INVOLVED IN MACROPHAGE RESPONSES TO LYMPHOKINE
    David Liu; Fiscal Year: 1990
    ..This proposal is aimed at the dissection of the interaction of one lymphokine, migration inhibitory factor (MIF), with its target cell the macrophage...
  42. Novel MLCK-MIF Interaction in Endothelium
    Ari Zaiman; Fiscal Year: 2002
    ..portion of EC MLCK was found to interact with a proinflammatory cytokine, macrophage migration inhibitory factor (MIF), a regulator of innate and acquired immunity with a pathologic role in ARDS, sepsis, and arthritis...
  43. Migration Inhibitory Factor in the Progression of EAE
    Caroline C Whitacre; Fiscal Year: 2010
    ..Migration inhibitory factor (MIF) has recently been re-discovered as an inducer of pro- inflammatory cytokines and an antagonist of glucocorticoid ..
  44. Roles of MIF and iNOS in SLE-associate inflammation
    Michael Hickey; Fiscal Year: 2007
    ..the involvement of mediators such as nitric oxide (NO) and the cytokine macrophage migration inhibitory factor (MIF) in the modulation of leukocyte-endothelial interactions...
  45. Mechanism of dendritic cell differentiation in cancer
    Dmitry I Gabrilovich; Fiscal Year: 2013
    ..suggest that tumor-mediated defects in DC differentiation as well as accumulation of MDSC could be controlled by S100A9 protein...
  46. A role for IL-1 in SJIA monocyte phenotypes: A RAPPORT ancillary study
    Elizabeth D Mellins; Fiscal Year: 2013
    ..Pro-inflammatory cytokines that are principally monocyte-derived, including IL-18, MIF, IL-6 and IL-1, are implicated in SJIA pathogenesis by transcriptional analysis and other studies...
  47. Multivalent Theranostics for Inflammation
    Sanjay Rajagopalan; Fiscal Year: 2012
    ..suggest a series of structured studies in relevant models of inflammation and atherosclerosis (ApoE-/- and ApoE-/-MRP14-/-)...
  48. Eosinophil:M2 Macrophage:CCL11 Axis in Experimental Colitis and Pediatric Cortico
    SIMON PATRICK HOGAN; Fiscal Year: 2013
    ..We will employ S100A9-/-, RAGE-/-, CCR2-/-, CCR2-/-/Il10-/- mice;use DSS- and NSAID-induced Il10-/- models of colitis;generate bone ..
  49. Functional and Structural Studies of CD74 Activation
    Elias Lolis; Fiscal Year: 2010
    ..CD74 has been identified as a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF). MIF is a pro-inflammatory protein that is secreted by cells upon exposure to microbes or their products...
  50. GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE
    Robert P Schleimer; Fiscal Year: 2013
    ..SPINK5 and molecules in the epidermal differentiation complex (EDC), including S100A7 (psoriasin), S100A8 and S100A9 (calgranulins A and B)...
  51. Immunity in alcoholic hepatitis.
    Zhang Xu Liu; Fiscal Year: 2013
    ..The plasma levels of DAMP molecules (HMGB1, Mitochondrial DNA, S100A8/S100A9 and cytokeratin-18) in control groups and AH patients will be examined...
  52. Keratinocyte Activation by Slug-induced Calprotectin
    Donna F Kusewitt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The calcium-binding EF-hand proteins S100A8 and S100A9 are released from damaged keratinocytes as the heterodimeric protein calprotectin...
  53. S100A8/A9 and carboxylated N-glycans in inflammation-mediated colon cancer
    GEETHA K SRIKRISHNA; Fiscal Year: 2010
    ..Calcium-binding heterodimeric proteins S100A8 and S100A9 are pro-inflammatory mediators that are also highly expressed in many tumors...
  54. NF-kB mediated induction of VEGFR-3 and new lymphatic vessels in breast cancer
    Sophia Ran; Fiscal Year: 2013
    ..Consistent with hyperactive NF-?B signaling, we found that NF-?B-inducing factors IL-1[unreadable], MIF and KC/CXCL1 are overexpressed in pro-lymphangiogenic breast tumor lines and act in concert with a VEGFR-3 specific ..
  55. Mechanisms of Rheumatoid Synovial Fibroblast Activation
    RICHARD J BUCALA; Fiscal Year: 2013
    ..Our research has focused on the role of the cytokine MIF, which we initially cloned together with its two-component receptor and found to sustain inflammatory responses by ..
  56. S100A9 and S100A8 in Diabetes and Atherosclerosis
    Karin E Bornfeldt; Fiscal Year: 2013
    ..atherosclerosis in a mouse model of type1diabetes, we discovered that the pro-inflammatory protein S100A9 is secreted at increased levels from macrophages from diabetic mice, and that immunoreactive S100A9 is abundant in ..
  57. Chemoprevention of upper aerodigestive tract cancer by dietary zinc
    Louise Y Y Fong; Fiscal Year: 2013
    ..have found that: (i) short-term dietary ZD in rats induces overexpression of proinflammation mediators, S100a8 and S100a9, associated with esophageal hyperplasia...
  58. Regulation of CXCR4 by cognate and non-cognate ligands
    Elias Lolis; Fiscal Year: 2013
    ..More recently, a non-cognate protein, macrophage migration inhibitory protein (MIF), was reported to functionally activate CXCR4. We verified that MIF and CXCR4 interact with each other...
  59. Role of MIF in Rb inactivation and Tumorigenesis
    Robert Mitchell; Fiscal Year: 2009
    ..We recently discovered that the pro-inflammatory cytokine, migration inhibitory factor (MIF) is both necessary and sufficient for mitogen and oncogene-induced cyclin D1 transcription, Cdk4 activity and Rb ..
  60. Role of Epithelium in Immunity, Inflammation and Disease
    Robert P Schleimer; Fiscal Year: 2013
    ..impairment in the expression of the important antimicrobial peptides psoriasin (S100A7) and calprotectin (S100A8/S100A9) in the epithelium of patients with CRS, suggesting diminished innate immune host defense...
  61. REGULATION OF MACROPHAGE MOTILITY BY COMPLEMENT
    Celso Bianco; Fiscal Year: 1980
    ..is concerned with complement derived stimuli which induce migration or local retention and their relationship to MIF (macrophage migration inhibitory factor)...
  62. Pro-inflammatory S100 protein as disease modifier in calcific aortic valve diseas
    MARION A HOFMANN-BOWMAN; Fiscal Year: 2013
    ..We now developed a new humanized transgenic mouse with expression of human S100/calgranulins (S100A12, S100A8 and S100A9) in tissues that normally express these proteins by using the human S100 gene cluster with its endogenous ..
  63. Dendritic Cell-Epithelial Cell Crosstalk in Human H. pylori Gastritis
    Diane Bimczok; Fiscal Year: 2013
    ..to chronic inflammation and gastric autoimmunit;and (3) Determine whether gastric DC secretion of IL-8 and MIF promotes epithelial cell proliferation through the CXCR2-EGF-R axis in H. pylori gastritis...
  64. Role of Receptor for Advanced Glycation End Product (RAGE) Pathway in Brain Tumor
    Behnam Badie; Fiscal Year: 2013
    ..technique will be used to measure intratumoral concentrations of RAGE- activating factors (S100B, S100A8, S100A9, HMGB1, and AGEs) in human gliomas propagated in rodents...
  65. Quantitative Methods for Genome-wide Analysis of Macrophage Activation by ESCs
    Jianqing Fan; Fiscal Year: 2013
    ..activation and teratoma development;and to unveil how the human MIFpolymorphisms associated with the serum MIF concentration in order to select patients for safe celltransplantation...
  66. Functional Restoration of the Optic Nerve After Disease or Damage
    Dong Feng Chen; Fiscal Year: 2010
    ..for the first time successful optic nerve re-elongation into the brain targets, up to postnatal day 14 (P14) in mice...
  67. GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE
    Robert Schleimer; Fiscal Year: 2009
    ..SPINK5 and molecules in the epidermal differentiation complex (EDC), including S100A7 (psoriasin), S100A8 and S100A9 (calgranulins A and B)...
  68. HYPOTHALAMUS & NARCOTIC EFFECTS
    HEMENDRA BHARGAVA; Fiscal Year: 1992
    ..CNS are involved in morphine tolerance-dependence and abstinence processes and (c) peptides like Pro-Leu-Gly-NH2 (MIF) and cyclo(Leu-Gly) (CLG) inhibit morphine tolerance-dependence and abstinence processes by affecting DA and opiate ..