Genomes and Genes
Gene Symbol: S100A9
Description: S100 calcium binding protein A9
Alias: 60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14, MRP-14, S100 calcium-binding protein A9 (calgranulin B), calgranulin B, calgranulin-B, calprotectin L1H subunit, leukocyte L1 complex heavy chain, migration inhibitory factor-related protein 14, protein S100-A9
Publications206 found, 100 shown here
- S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunityWolfgang Nacken
Institute of Experimental Dermatology, University of Munster, 48149 Munster, Germany
Microsc Res Tech 60:569-80. 2003..As unspecific phagocytes, they belong to the so-called innate immunity. Two S100 proteins, namely S100A9 (MRP14) and S100A8 (MRP8), constitute roughly 40% of the cytosolic protein in these cells, implying by their pure ..
- S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesisJulia Nemeth
Division of Signal Transduction and Growth Control A100, German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Heidelberg, Germany
Hepatology 50:1251-62. 2009..HCC) revealed a comprehensive list of known and novel putative NF-kappaB target genes, including S100a8 and S100a9. We detected increased co-expression of S100A8 and S100A9 proteins in mouse HCC cells, in human HCC tissue, and in ..
- The crystal structure of human MRP14 (S100A9), a Ca(2+)-dependent regulator protein in inflammatory processHiroshi Itou
Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060 0810, Japan
J Mol Biol 316:265-76. 2002Human MRP14 (hMRP14) is a Ca(2+)-binding protein from the S100 family of proteins...
- Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancerAlexander Hermani
Research Group Hormones and Signal Transduction, German Cancer Research Center, Heidelberg, Germany
Clin Cancer Res 11:5146-52. 2005..We examined the expression of two members of this family, S100A8 and S100A9, together with the S100 receptor RAGE (receptor for advanced glycation end products) in human prostate ..
- Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesionCarle Ryckman
Infectious Diseases Research Center, Laval University Hospital Center, Sainte Foy, Quebec, Canada
J Immunol 170:3233-42. 2003S100A8 and S100A9 are small calcium-binding proteins that are highly expressed in neutrophil and monocyte cytosol and are found at high levels in the extracellular milieu during inflammatory conditions...
- Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cellsDorothee Viemann
Institute of Experimental Dermatology, Integrated Functional Genomics, and the Interdisciplinary Clinical Research Center, University Hospital Muenster, University of Muenster, Röntgenstrasse 21, 48149 Muenster, Germany
Blood 105:2955-62. 2005Myeloid-related protein 8 (MRP8) and MRP14, S100 proteins secreted by activated phagocytes, bind specifically to endothelial cells. The endothelial response to MRP8/MRP14, however, is unknown...
- S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathwaySaeid Ghavami
Manitoba Institute of Cell Biology and Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada
J Leukoc Biol 83:1484-92. 2008..RAGE small interfering RNA pretreatment abrogated the S100A8/A9-induced NF-kappaB activation. Our data indicate that S100A8/A9-promoted cell growth occurs through RAGE signaling and activation of NF-kappaB...
- S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cellsAlexander Hermani
Research Group Hormones and Signal Transduction, German Cancer Research Centre, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Exp Cell Res 312:184-97. 2006..Deregulated expression of S100 proteins, including S100A8 and S100A9, was reported in association with neoplastic disorders...
- S100A8 and S100A9: new insights into their roles in malignancyGeetha Srikrishna
Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
J Innate Immun 4:31-40. 2012..In this regard, damage-associated molecular pattern (DAMP) molecules such as S100A8 and S100A9, with well-known functions in inflammation, have been increasingly recognized not only as markers, but also as new ..
- RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesisOlga Turovskaya
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
Carcinogenesis 29:2035-43. 2008..In human colon tumor tissues and in a mouse model of CAC, we found that myeloid progenitors expressing S100A8 and S100A9 infiltrate regions of dysplasia and adenoma. mAbGB3...
- Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritisK Odink
Department of Biotechnology, Ciba Geigy, Basel, Switzerland
Nature 330:80-2. 1987..Characterization of MRP-8 and MRP-14 could therefore be useful to the understanding of cellular processes induced in chronic inflammation...
- MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death programDorothee Viemann
Institute of Experimental Dermatology, University of Munster, Germany
Blood 109:2453-60. 2007Activated phagocytes express considerable amounts of MRP8 and MRP14, 2 calcium-binding S100 proteins forming stable heterodimers that are specifically secreted at inflammatory sites in many diseases...
- The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritisKatsue Sunahori
Department of Medicine and Clinical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
Arthritis Res Ther 8:R69. 2006S100A8 and S100A9, two Ca2+-binding proteins of the S100 family, are secreted as a heterodimeric complex (S100A8/A9) from neutrophils and monocytes/macrophages...
- The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophilsR A Newton
Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, United Kingdom
J Immunol 160:1427-35. 1998..protein (MRP-14) and its heterodimeric partner, MRP-8, are members of the S100 family of calcium-binding proteins (S100A9 and S100A8, respectively)...
- Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiationAndreas Voss
Institute of Immunology, University of Muenster, Muenster, Germany
FEBS Lett 585:440-6. 2011..S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair...
- S100A8/A9 induces apoptosis and inhibits metastasis of CasKi human cervical cancer cellsFengjin Qin
Gynaecology and Obstetrics Department, Peking University Third Hospital, Beijing, People s Republic of China
Pathol Oncol Res 16:353-60. 2010..Deregulated expression of S100 proteins, including S100A9 and its partner S100A8, was reported to be associated with neoplastic disorders...
- Induction of nuclear factor-κB responses by the S100A9 protein is Toll-like receptor-4-dependentMatteo Riva
Immunology Group, Lund University, Lund, Sweden
Immunology 137:172-82. 2012..In this report, we investigated the capacity of lipopolysaccharide (LPS) -free S100A9 (DAMP) protein to activate human and mouse cells compared with lipoprotein-free LPS (PAMP)...
- S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2Saeid Ghavami
Manitoba Institute of Cell Biology, Canada
Biochim Biophys Acta 1783:297-311. 2008..Together, these data indicate that S100A8/A9-induced cell death involves Bak, selective release of Smac/DIABLO and Omi/HtrA2 from mitochondria, and modulation of the balance between pro- and anti-apoptotic proteins...
- MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent mannerJ Roth
Institute of Experimental Dermatology, University of Munster, Germany
Blood 82:1875-83. 1993MRP8 and MRP14 are two Ca(2+)-binding proteins of the S-100 family expressed by myelomonocytic cells. Both proteins assemble to noncovalently associated complexes in a Ca(2+)-dependent manner...
- Loss of myeloid-related proteins 8 and myeloid-related proteins 14 expression in human esophageal squamous cell carcinoma correlates with poor differentiationJian Ping Kong
National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
World J Gastroenterol 10:1093-7. 2004..proteins(MRP)8 and myeloid-related proteins(MRP)14 in human esophageal squamous cell carcinoma and to investigate if there was any correlation between MRP8 and MRP14 expression level and histopathological grade in these tumors.
- The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritisMichael Frosch
University of Muenster, Muenster, Germany
Arthritis Rheum 60:883-91. 2009..We undertook this study to analyze the relevance of myeloid-related proteins (MRPs) 8 and 14, endogenous activators of Toll-like receptor 4, in diagnosis and pathogenesis of systemic-onset JIA...
- Analysis of the MRP8-MRP14 protein-protein interaction by the two-hybrid system suggests a prominent role of the C-terminal domain of S100 proteins in dimer formationC Propper
Institute of Experimental Dermatology, Münster Medical School, Von Esmarch Strasse 56, D 48149 Munster, Germany
J Biol Chem 274:183-8. 1999..Using the two-hybrid system we analyzed the dimerization of MRP8 (S100A8) and MRP14 (S100A9), two S100 proteins expressed in myeloid cells...
- Calprotectin S100A9 calcium-binding loops I and II are essential for keratinocyte resistance to bacterial invasionChantrakorn Champaiboon
Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Biol Chem 284:7078-90. 2009Epithelial cells expressing calprotectin, a heterodimer of S100A8 and S100A9 proteins, are more resistant to bacterial invasion...
- Decreases in serum levels of S100A8/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritisLucie Andrés Cerezo
Institute of Rheumatology, First Medical Faculty, Charles University, Na Slupi 4, 128 50 Prague 2, Czech Republic
Arthritis Res Ther 13:R122. 2011..The aim of this study was to examine the serum levels of S100 proteins and to evaluate their role in patients with recent-onset rheumatoid arthritis (RA)...
- Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ionsSaeid Ghavami
Clinical Biochemistry Department, Faculty of Medical Sciences, Tarbiat Modaress University, P O BOX 14115 111, Tehran, I R, Iran
J Leukoc Biol 76:169-75. 2004....
- Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathwayMizhir Atallah
The Laboratory for Cellular and Molecular Immunology, Department of Medicine, Hadassah Hebrew University Medical Center Jerusalem, Jerusalem, Israel
PLoS ONE 7:e29333. 2012..This mechanism is suggested to have a fine-tuning role in regulating the neutrophil number in bone marrow, peripheral blood, and inflammatory sites...
- RAGE-dependent regulation of calcium-binding proteins S100A8 and S100A9 in human THP-1K Eggers
Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Campus Mitte, Germany
Exp Clin Endocrinol Diabetes 119:353-7. 2011..we determined the effects of proinflammatory cytokines on RAGE-mediated induction of gene expression of S100A8 and S100A9. mRNA levels of S100A8 and S100A9 were upregulated following cytokine stimulation with IL-6 (1, 10, 100 ng/ml) ..
- Expression of MRP14 gene is frequently down-regulated in Chinese human esophageal cancerJie Wang
National Laboratory of Molecular Oncology, Cancer Institute Hospital, Chinese Academy of Medical Sciences, Peking University of Medical School, Beijing 100021, China
Cell Res 14:46-53. 2004Migration inhibitory factor-related protein 14 (MRP14) is one of calcium-binding proteins, referred as S100A9. The heterodimeric molecule formed by MRP14 with its partner MRP8 (S100A8) is the major fatty acid carrier in neutrophils...
- Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activitySatoru Yui
Faculty of Pharmaceutical Sciences, Teikyo University, Tsukui gun, Kanagawa, Japan
Mediators Inflamm 11:165-72. 2002..of 8 and 14 kDa subunits, which have also been termed migration inhibitory factor-related proteins MRP8 and MRP14. We previously reported that rat calprotectin purified from inflammatory neutrophils induces apoptosis of various ..
- S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576 mice, AD animal modelTae Young Ha
Department of Pharmacology, College of Medicine, National Creative Research Initiative Center for Alzheimer s Dementia and Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea
PLoS ONE 5:e8840. 2010..we performed microarray analysis with APP(V717I)-CT100 transgenic mice, an animal model of AD, and isolated the S100a9 gene, which encodes an inflammation-associated calcium binding protein...
- Phagocyte-specific S100A8/A9 protein levels during disease exacerbations and infections in systemic lupus erythematosusMuhammad S Soyfoo
Department of Rheumatology, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070, Bruxelles, Belgium
J Rheumatol 36:2190-4. 2009S100A8 and S100A9 are calcium binding proteins of the S100 family highly expressed in neutrophils and monocytes. S100 proteins are novel ligands of TLR4 important in modulating inflammation...
- S100A8/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytesTakamasa Nukui
Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikatachou, Okayama 700 8558, Japan
J Cell Biochem 104:453-64. 2008S100A8 and S100A9 are known to be up-regulated in hyperproliferative and psoriatic epidermis, but their function in epidermal keratinocytes remains largely unknown...
- Serum and mucosal S100 proteins, calprotectin (S100A8/S100A9) and S100A12, are elevated at diagnosis in children with inflammatory bowel diseaseSteven T Leach
School of Women s and Children s Health, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
Scand J Gastroenterol 42:1321-31. 2007..The objective of this study was to assess serum and mucosal levels of calprotectin, S100A12 and soluble receptor for advanced glycation end products (sRAGE), a putative S100 ligand, in a paediatric population with IBD...
- The S100 family of EF-hand calcium-binding proteins: functions and pathologyB W Schafer
Department of Pediatrics, University of Zurich, Switzerland
Trends Biochem Sci 21:134-40. 1996..Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging...
- Up-regulation of metastasis-promoting S100A4 (Mts-1) in rheumatoid arthritis: putative involvement in the pathogenesis of rheumatoid arthritisJorg Klingelhofer
Danish Cancer Society, Copenhagen, Denmark
Arthritis Rheum 56:779-89. 2007..To examine the involvement of the metastasis-inducing protein S100A4 (Mts-1) in the pathogenesis of rheumatoid arthritis (RA)...
- S100A8 and S100A9 overexpression is associated with poor pathological parameters in invasive ductal carcinoma of the breastKazumori Arai
Department of Pathology, Shizuoka General Hospital, 4 27 1 Kitaando, Aoi ku, Shizuoka 420 0881, Japan
Curr Cancer Drug Targets 8:243-52. 2008S100 protein A8 and A9 naturally form a stable heterocomplex. Recently, we have proved that S100A9 overexpression in various adenocarcinomas is associated with poor tumor differentiation...
- S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathwayRui Wu
Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P R China
Int J Oncol 42:1001-10. 2013The S100A9 protein, a member of the S100 protein family, is often upregulated in various types of cancer, including hepatocellular carcinoma (HCC)...
- Expression of myeloid-related protein-8 and -14 in patients with acute Kawasaki diseaseKeiich Hirono
Department of Pediatrics, Toyama University, Toyama, Japan
J Am Coll Cardiol 48:1257-64. 2006..This study investigated patients with acute Kawasaki disease (KD) to validate myeloid-related protein (MRP)-8/MRP-14 as a marker of disease activity and severity of coronary artery lesion development...
- Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosusChristian Lood
Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Solvegatan 23, 223 62 Lund, Sweden
Arthritis Res Ther 13:R60. 2011..The heterodimer of the cytosolic calcium-binding proteins S100A8 and S100A9 (S100A8/A9) is secreted by activated polymorphonuclear neutrophils (PMNs) and monocytes and serves as a serum ..
- Myeloid related protein-8/14 stimulates interleukin-8 production in airway epithelial cellsAli Ahmad
Respiratory Research Laboratory, Department of Medicine, University of Birmingham, Birmingham B15 2TT, UK
Am J Respir Cell Mol Biol 29:523-30. 2003....
- Prognostic impact of S100A9 overexpression in non-small cell lung cancerHideki Kawai
Department of Thoracic Surgery, Akita Red Cross Hospital, 222 1 Naeshirosawa, Saruta, Kamikitate, Akita, 010 1495, Japan
Tumour Biol 32:641-6. 2011S100 proteins have been implicated in the progression and metastasis of several cancers. Among the S100 family, S100A9 is reportedly expressed in non-small cell lung cancer (NSCLC), though the clinical significance and prognostic value of ..
- Local calprotectin production in colorectal cancer and polyps--active neutrophil recruitment in carcinogenesisKim Luley
First Department of Medicine, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
Int J Colorectal Dis 26:603-7. 2011..Calprotection expression was correlated with neutrophil infiltration, markers of bacteremia, and systemic inflammation...
- Transendothelial migration of 27E10+ human monocytesI Eue
Institute of Experimental Dermatology, University of Munster, Von Esmarch Strasse 56, 48149 Munster, Germany
Int Immunol 12:1593-604. 2000The myeloid-related proteins MRP8 (S100A8) and MRP14 (S100A9), two members of the S100 family of calcium-binding proteins, are co-expressed and form a cell-surface and cytoskeleton-associated heterodimer upon calcium mobilization which is ..
- Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophilsGeorge Lominadze
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, KY 40202, USA
J Immunol 174:7257-67. 2005..Direct phosphorylation of the MRP-14/MRP-8 complex by p38 MAPK increased actin binding in vitro by 2-fold. These results indicate that MRP-14 is a potential mediator of p38 MAPK-dependent functional responses in human neutrophils...
- Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14J Edgeworth
Macrophage Laboratory, Lincoln s Inn Fields, UK
Nature 342:189-92. 1989..are variously referred to as the cystic fibrosis antigen, the L1 light chain, MRP-8 or p8, and the L1 heavy chain, MRP14 or p14, respectively...
- Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein familyB W Schafer
University of Zurich, Department of Pediatrics, Switzerland
Genomics 25:638-43. 1995..The new nomenclature should facilitate and further the understanding of this protein family and be easily expandable to other species...
- Global gene expression profiling unveils S100A8/A9 as candidate markers in H-ras-mediated human breast epithelial cell invasionAree Moon
College of Pharmacy, Duksung Women s University, Seoul, Korea
Mol Cancer Res 6:1544-53. 2008..We then tested whether S100A8 and S100A9, two of the genes which are most highly up-regulated in an H-Ras-specific manner, play a causative role for H-Ras-..
- S100 proteins in Corpora amylacea from normal human brainD Hoyaux
Laboratory of Histopathology, Erasmus University Hospital, Faculty of Medicine, Université Libre de Bruxelles CP 620, 808 Route de Lennik, 1070, Brussels, Belgium
Brain Res 867:280-8. 2000..the presence of different S100 proteins (S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A8, S100A9, S100A12 and S100B) in C.A. from normal human brain...
- Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiationE Lagasse
Department of Biotechnology, Ciba Geigy, Basel, Switzerland
Mol Cell Biol 8:2402-10. 1988..Two proteins, MRP8 and MRP14, which are expressed in infiltrate macrophages during inflammatory reactions but not in normal tissue macrophages, ..
- HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytesCarle Ryckman
Centre de Recherche en Infectiologie, Pavillon Centre Hospitalier de l Université Laval, Centre Hospitalier Universitaire de Quebec, and Département de Biologie Médicale, Faculte de Medecine, Universite Laval, Quebec, Canada
J Immunol 169:3307-13. 2002S100A8, S100A9, and S100A12, collectively known as myeloid-related proteins (MRPs), are highly expressed by the myeloid cell lineage and are found in the extracellular milieu during infections and inflammatory conditions...
- Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritisYueh Sheng Chen
Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia
Arthritis Res Ther 11:R39. 2009..This study evaluated the serum levels of S100A9, S100A8, S100A12 and sRAGE in RA patients, to determine their relationship to inflammation and joint and vascular ..
- Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathyKlaus Burkhardt
Nephrological Clinic Weissenburg, 91781 Weissenburg, Germany
Cardiovasc Diabetol 8:10. 2009..We investigated whether myeloid-related protein 8/14 complex (MRP8/14) secreted by transmigrating monocytes and granulocytes may represent a biomarker for microvascular alterations in patients with type 2 diabetes and nephropathy...
- The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2Claus Kerkhoff
Institute of Experimental Dermatology, University of Munster, Germany
FASEB J 19:467-9. 2005..its functional relevance by the impaired oxidase activity in neutrophil-like NB4 cells, after specific blockage of S100A9 expression, and bone marrow polymorphonuclear neutrophils from S100A9-/- mice...
- Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cationsThomas Vogl
Institute of Experimental Dermatology, University of Muenster, Roentgenstrasse 21, 48149 Muenster, Germany
Biochim Biophys Acta 1763:1298-306. 2006S100A8 and S100A9 are two proinflammatory molecules belonging to the S100 family of calcium-binding proteins...
- S100A8 and S100A9 in human arterial wall. Implications for atherogenesisMichelle M McCormick
School of Medical Sciences, St Vincent s Hospital, University of New South Wales, Sydney, Australia
J Biol Chem 280:41521-9. 2005Atherogenesis is a complex process involving inflammation. S100A8 and S100A9, the Ca2+-binding neutrophil cytosolic proteins, are associated with innate immunity and regulate processes leading to leukocyte adhesion and transmigration...
- Inflammatory S100A9 and S100A12 proteins in Alzheimer's diseaseC E Shepherd
Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney 2031, Australia
Neurobiol Aging 27:1554-63. 2006..S100A8, S100A9 and S100A12 comprise a new group of inflammation-associated proteins that are constitutively expressed by ..
- S100A8, S100A9 and the S100A8/A9 heterodimer complex specifically bind to human endothelial cells: identification and characterization of ligands for the myeloid-related proteins S100A9 and S100A8/A9 on human dermal microvascular endothelial cell line-1 cInes Eue
PAN Clinic, Zeppelinstrasse 1, 50667 Köln, Germany
Int Immunol 14:287-97. 2002..We demonstrate that S100A8, S100A9 and the S100A8/A9 heterodimeric complex bind to human dermal microvascular endothelial cell line (HMEC)-1 with an ..
- Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectinGerben Bouma
Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
Diabetes 53:1979-86. 2004....
- TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteinsPooja Pungaliya
Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08901, USA
J Proteome Res 6:3918-23. 2007..Transfection studies confirmed mammalian Sin3A as a sumoylation substrate for TOPORS. These findings suggest that TOPORS may function as a tumor suppressor by regulating mSin3A and other proteins involved in chromatin modification...
- Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end productsPhilipp Ehlermann
Universitat Heidelberg, Abteilung Innere Medizin III, Heidelberg, Germany
Cardiovasc Diabetol 5:6. 2006..As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression.
- Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activityNadja Leukert
Institute of Experimental Dermatology, University of Muenster, Roentgenstr 21, 48149 Muenster, Germany
J Mol Biol 359:961-72. 2006..The heterodimers of S100A8 and S100A9 represent the major calcium-binding proteins in phagocytes...
- The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophilsC Kerkhoff
Institut für Experimentelle Dermatologie, 48149 Munster, Germany
J Biol Chem 274:32672-9. 1999Recently, we identified the two myeloid related protein-8 (MRP8) (S100A8) and MRP14 (S100A9) as fatty acid-binding proteins (Klempt, M., Melkonyan, H., Nacken, W., Wiesmann, D., Holtkemper, U., and Sorg, C. (1997) FEBS Lett. 408, 81-84)...
- Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritisMichael Frosch
Institute of Experimental Dermatology and Department of Pediatrics, University of Munster, Munster, Germany
Arthritis Rheum 48:2622-6. 2003....
- Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)C Kerkhoff
Institut für Experimentelle Dermatologie, Munster, Germany
Biochim Biophys Acta 1448:200-11. 1998The two migration inhibitory factor- (MIF)-related protein-8 (MRP8; S100A8) and MRP14 (S100A9) are two calcium-binding proteins of the S100 family...
- Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expressionJens Grote
Institute of Experimental Dermatology, University of Muenster, Germany
BMC Mol Biol 7:48. 2006..Dysregulated expression of S100 proteins, including S100A9, has been reported in the epidermis as a response to stress and in association with neoplastic disorders...
- The hetero-oligomeric complex of the S100A8/S100A9 protein is extremely protease resistantWolfgang Nacken
Institute for Experimental Dermatology, University of Muenster, Roentgenstrasse 21, 48149 Muenster, Germany
FEBS Lett 581:5127-30. 2007S100A8, S100A9 and S100A12 proteins are associated with inflammation and tissue remodelling, both processes known to be associated with high protease activity...
- Binding of two nuclear complexes to a novel regulatory element within the human S100A9 promoter drives the S100A9 gene expressionClaus Kerkhoff
Institute of Experimental Dermatology, 48149 Muenster, Germany
J Biol Chem 277:41879-87. 2002b>S100A9, also referred to as MRP14, is a calcium-binding protein whose expression is tightly regulated during differentiation of myeloid cells...
- Biochemical characterization of the murine S100A9 (MRP14) protein suggests that it is functionally equivalent to its human counterpart despite its low degree of sequence homologyW Nacken
Institute of Experimental Dermatology, University of Munster, Germany
Eur J Biochem 267:560-5. 2000Due to the low degree of sequence similarity it has been speculated that murine and human S100A9 (MRP14), an inflammatory marker protein belonging to the S100 protein family, may have different cellular functions in mouse and man...
- S100A8 and S100A9 in experimental osteoarthritisHala Zreiqat
Tissue Engineering and Biomaterials Research Unit, School of AMME J07, Faculty of Engineering, Bosch Institute, University of Sydney, Corner of Shepherd and Cleavland Street, New South Wales 2006, Australia
Arthritis Res Ther 12:R16. 2010The objective was to evaluate the changes in S100A8 S100A9, and their complex (S100A8/S100A9) in cartilage during the onset of osteoarthritis (OA) as opposed to inflammatory arthritis.
- Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitroMarie Pierre Manitz
Institute of Experimental Dermatology, Zentrum fur Molekularbiologie der Entzundung, Univeristy of Münster, 48149 Munster, Germany
Mol Cell Biol 23:1034-43. 2003The S100A9 (MRP14) protein is abundantly expressed in myeloid cells and has been associated with various inflammatory diseases. The S100A9-deficient mice described here were viable, fertile, and generally of healthy appearance...
- Immunohistochemical investigation of S100A9 expression in pulmonary adenocarcinoma: S100A9 expression is associated with tumor differentiationK Arai
Department of Pathology, Shizuoka General Hospital, Shizuoka 420 0881, Japan
Oncol Rep 8:591-6. 2001..However, there have been few studies on S100A9 in specific types of carcinomas, except for squamous cell carcinoma (SCC) because the expression in normal ..
- An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swineT Lewis
Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Greenport, New York 11944 0848, USA
J Virol 74:1275-85. 2000..Time course analysis and viral DNA synthesis inhibitor experiments indicated that p14 was a late viral protein...
- Immunopathogenic mechanisms in hypertensionN Lefkos
Cardiology Unit, Aristotle University of Thessaloniki, Hippokration Hospital, Greece
Am J Hypertens 8:1141-5. 1995..immunity against arterial wall antigen was studied in all subjects by means of migration inhibitory factor (MIF) against relevant antigen preparation...
- Vascular actions of thrombin receptor-derived polypeptides: structure-activity profiles for contractile and relaxant effects in rat aortaA A Laniyonu
Department of Pharmacology and Therapeutics, University of Calgary, Faculty of Medicine, AB Canada
Br J Pharmacol 114:1680-6. 1995..Rat P5-NH2), SFLLRNP (P7), SFLLRNP-NH2 (P7-NH2), SFFLRNP (Rat P7), SFFLRNP-NH2 (Rat P7-NH2), and SFLLRNPNDKYEPF (P14). 2...
- Granulomatous slack skin in childhoodF M Camacho
Department of Medical-Surgical Dermatology, Hospital Universitario Virgen Macarena, Universidad de Sevilla, Spain
Pediatr Dermatol 14:204-8. 1997..The phenotype of the giant cells was lysozyme positive, CD68+ and Mac387-...
- Side effects of antibiotics on immune response parameters and their possible implications in antimicrobial chemotherapyG Gillissen
Institute of Medical Microbiology, Medical Faculty, , Aachen
Zentralbl Bakteriol Mikrobiol Hyg A 270:171-99. 1988..g. foodpad swelling reaction, MIF-production, mitogen/antigen induced lymphocyte proliferation and delayed type hypersensitivity skin reaction), on ..
- The monocyte/macrophage infiltrate in 35 medulloblastomas: a paraffin-wax studyM L Rossi
Department of Neuropathology, Midland Centre for Neurosurgery and Neurology, Birmingham, United Kingdom
Tumori 77:36-40. 1991..tissue from 35 medulloblastomas, collected over 23 years (27 non-desmoplastic and 8 desmoplastic) with KP1 and Mac387 two monoclonal anti-monocytes/macrophage (M/Ms) antibodies recommended for use on paraffin wax embedded tissue...
- Effect of vitamin E on production of macrophage migration inhibitory factor (MIF) by macrophagesW Sakamoto
Department of Biochemistry, School of Dentistry, Hokkaido University, Sapporo, Japan
Biofactors 10:139-43. 1999Macrophage migration inhibitory factor (MIF), a putative cytokine involved in inflammatory and immune responses, was identified in rat peritoneal macrophages by Western blot analysis and its secretion into culture medium by enzyme-linked ..
- [Studies on transference of hydrogenase genes of Rhizobium arachis]Z Wang
Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
Wei Sheng Wu Xue Bao 41:421-6. 2001The hydrogen-uptake genes were transferred into wild Rhizobium arachis Ra strains (Hup-, Nif+, Apr) by triparental mating using pRK2013 as help plasmid. A transconjugant R...
- A heterocomplex formed by the calcium-binding proteins MRP8 (S100A8) and MRP14 (S100A9) binds unsaturated fatty acids with high affinityG Siegenthaler
Clinique de Dermatologie, Hopital Cantonal Universitaire, CH 1211 Geneve 14, Switzerland
J Biol Chem 272:9371-7. 1997..by the non-covalent association of two calcium-binding proteins of the S100 family: MRP8 (S100A8) and MRP14 (S100A9). Fatty acid-competition studies on the [3H]oleic acid...
- [A case of fulminant psittacosis necessitating mechanical ventilation diagnosed by chlamydial isolation form BALF]H Taniguchi
Third Department of Internal Medicine, Miyazaki Medical College, Japan
Kansenshogaku Zasshi 69:1396-401. 1995..diagnosis was established with a significant rise of both IgG and IgM antibody against Chlamydia psittaci with MIF and identification of Chlamydia with the cell culture method...
- Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cellsTadamichi Shimizu
Departments of Dermatology and Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
J Biol Chem 279:13729-37. 2004Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has been shown to play a role in wound-healing processes...
- Association of interindividual differences in p14ARF promoter methylation with single nucleotide polymorphism in primary colorectal cancerMi Yeon Kang
Center for Genome Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Kangnam Ku, Seoul, South Korea
Cancer 112:1699-707. 2008..The objective of the current study was to understand whether single nucleotide polymorphisms (SNPs) around the promoter of a gene are implicated in the interindividual differences of CpG island hypermethylation...
- Long-term effect of nifedipine and hydrochlorothiazide on blood pressure and sodium homeostasis at varying levels of salt intake in mildly hypertensive patientsF C Luft
Department of Internal Medicine-Nephrology, , Germany
Am J Hypertens 4:752-60. 1991To elucidate and compare the effects of nifedipine (NIF) and hydrochlorothiazide (HCTZ) on blood pressure (BP) and sodium (Na) balance, we conducted a randomized, double-blind, crossover study with 50 mg/day HCTZ and 90 mg/day NIF (as ..
- [Spontaneous cure of pneumonia caused by Chlamydia pneumoniae]N Miyashita
Department of Medicine, Kawasaki Medical School
Kansenshogaku Zasshi 69:934-9. 1995..512-fold in the acute phase and decreased to 32-fold in the convalescent phase using the micro-immunofluorescence (MIF) test, indicating a C. pneumoniae acute infection. In fact, no other micro-organisms were detected...
- Xefiltin, a new low molecular weight neuronal intermediate filament protein of Xenopus laevis, shares sequence features with goldfish gefiltin and mammalian alpha-internexin and differs in expression from XNIF and NF-LY Zhao
Department of Biological Sciences, University at Albany, State University of New York 12222, USA
J Comp Neurol 377:351-64. 1997..mammals, the progressive maturation of neurons is marked by successive changes in neuronal intermediate filament (nIF) subunit composition...
- Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infectionChristian Østergaard
Department of Clinical Microbiology, Copenhagen University Hospital Herlev, Herlev Ringvej, DK 2730 Herlev, Denmark
Crit Care 13:R101. 2009Macrophage migration inhibitory factor (MIF) plays an essential pathophysiological role in septic shock, but its role in central nervous system infection (CNS) remains to be defined.
- Increase in macrophage migration inhibitory factor levels in lacrimal fluid of patients with severe atopic dermatitisNobuyoshi Kitaichi
Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, 060 8638, Sapporo, Japan
Graefes Arch Clin Exp Ophthalmol 244:825-8. 2006..Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is associated with the generation of cell-mediated immune responses...
- [A child with iritis due to Chlamydia pneumoniae infection]S Yamada
Department of Pediatrics, Kurume University School of Medicine
Kansenshogaku Zasshi 68:1543-7. 1994..pneumoniae infection was made by specific polymerase chain reaction (PCR) method and microimmunofluorescence test (MIF). The symptoms subsided with administration of clarithromycin (CAM: 300 mg/day) for 2 weeks...
- Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathyY G Kim
Division of Nephrology, University of Washington Medical Center, Seattle, USA
Mol Med 6:837-48. 2000..We hypothesized that uric acid crystal deposition may induce granuloma formation by stimulating local expression of macrophage migration inhibitory factor (MIF), which is a known mediator of delayed type hypersensitivity (DTH).
- A switch in the cellular localization of macrophage migration inhibitory factor in the rat testis after ethane dimethane sulfonate treatmentA Meinhardt
Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
J Cell Sci 112:1337-44. 1999Macrophage migration inhibitory factor (MIF), one of the first cytokines to be discovered, has recently been localized to the Leydig cells in adult rat testes...
- The cytokine macrophage migration inhibitory factor reduces pro-oxidative stress-induced apoptosisMai Tuyet Nguyen
Laboratory of Biochemistry, Institute for Interfacial Engineering, University of Stuttgart and Fraunhofer Institut für Grenzflächen und Bioverfahrenstechnik, Stuttgart, Germany
J Immunol 170:3337-47. 2003The cytokine macrophage migration inhibitory factor (MIF) exhibits pro- and anti-inflammatory activities and regulates cell proliferation and survival. We investigated the effects of MIF on apoptosis...
- The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteinsIngo P Korndörfer
Lehrstuhl fur Biologische Chemie, Technische Universitat Munchen, Freising Weihenstephan, Germany
J Mol Biol 370:887-98. 2007The EF-hand proteins S100A8 and S100A9 are important calcium signalling proteins that are involved in wound healing and provide clinically relevant markers of inflammatory processes, such as rheumatoid arthritis and inflammatory bowel ..
- Interferon-tau stimulates secretion of macrophage migration inhibitory factor from bovine endometrial epithelial cellsBingtuan Wang
Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec J2S 7C6, Canada
Biol Reprod 69:1690-6. 2003..12-kDa protein contained a partial amino acid sequence that corresponded to macrophage migration inhibitory factor (MIF)...
- Nonintracranial fatal firearm injuries in children: implications for treatmentMichael L Nance
Department of Surgery, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Trauma 55:631-5. 2003Understanding the injury characteristics of nonintracranial fatal (NIF) gunshot wounds in children treated in a statewide trauma system will help guide effective treatment strategies.
- Soluble components of Histoplasma capsulatum var. capsulatum have hemagglutinin activity and induce syngeneic hemophagocytosis in vitroR H F Vivan
Departamento de Ciências Patológicas, CCB, Universidade Estadual de Londrina, Campus Universitario, Londrina, PR, 86051 970, Brazil
Mycopathologia 169:151-7. 2010..activity, mouse red blood cells (RBC) (1% v/v in PBS) were incubated (37 degrees C, 1 h) with cell-free antigen (CFAg) from H. capsulatum var...
- Oxidation of methionine 63 and 83 regulates the effect of S100A9 on the migration of neutrophils in vitroHerve Y Sroussi
Department of Oral Medicine, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7213, USA
J Leukoc Biol 81:818-24. 2007The calcium-binding proteins S100A8 and S100A9 and their heterocomplex calprotectin are abundant cytosolic constituents in human neutrophils, constitutively expressed by mucosal epithelium and in association with inflammation by epidermal ..
- High expression of myeloid-related proteins 8 and 14 characterizes an inflammatorily active but ineffective response of macrophages during leprosyCord H Sunderkötter
Institute of Experimental Dermatology, University of Munster, Munster, Germany
Immunology 111:472-80. 2004..Expression and release of the myeloid-related protein (MRP) 8 and MRP14 (S100A8 and S100A9) characterize a proinflammatory subtype of macrophage that is prominent in, for example, murine infection with ..
- Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitisYoshitaka Sakai
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
Gastroenterology 124:725-36. 2003Macrophage migration inhibitory factor (MIF), originally described as an inhibitor of the random migration of macrophages, has been shown recently to be involved in the pathogenesis of several inflammatory diseases such as sepsis...
- Dermal dendrocytes in Dupuytren's disease: a link between the skin and pathogenesis?P Sugden
Department of Pathological Sciences, University of Manchester, Salford, UK
J Hand Surg Br 18:662-6. 1993..Immunohistochemistry was performed using a panel of antibodies for factor XIIIa, macrophages (CD68 and MAC387) and MHC II...
- [Role of macrophage migration inhibitory factor in septic shock-induced cardiovascular dysfunction: experiment with rats]Fu Zhou Wang
Department of Anesthesia, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China
Zhonghua Yi Xue Za Zhi 87:768-73. 2007To investigate the role of macrophage migration inhibitory factor (MIF) in septic shock-induced cardiovascular dysfunction.
- MIF AND THE HOST RESPONSE TO INFECTIONRICHARD J BUCALA; Fiscal Year: 2013..In 1993, we cloned murine macrophage migration inhibitory factor (MIF) as an upstream regulator of innate immunity and mediator of lethal shock...
- Immunoregulation of Myelin Specific T LymphocytesArthur A Vandenbark; Fiscal Year: 2013..on the monocyte cell surface and blocking the inflammatory effects of macrophage migration inhibitory factor (MIF) that is a key pathogenic cytokine for EAE and MS...
- MIF in progression and treatment of ALDLaura E Nagy; Fiscal Year: 2013..a pre- clinical mouse model of chronic ethanol exposure, we have identified macrophage migration inhibitory factor (MIF) as an important contributor to ethanol-induced steatosis and inflammation...
- Innate and Adaptive Immune Mechanisms in ArthritisRICHARD J BUCALA; Fiscal Year: 2013..Since our initial cloning of murine macrophage migration inhibitory factor (MIF), we have focused on the role of this mediator in the pathogenesis of rheumatoid arthritis...
- Chemopreventition and treatment of non-melanoma skin cancer by targeting MIFAbhay R Satoskar; Fiscal Year: 2013..Macrophage migration inhibitory factor (MIF) is a pleiotropi cytokine which is produced by variety of cells, including activated macrophages and neutrophils...
- Functional and Structural Studies of CD74 ActivationElias Lolis; Fiscal Year: 2010..CD74 has been identified as a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF). MIF is a pro-inflammatory protein that is secreted by cells upon exposure to microbes or their products...
- Regulation of Hypoxic Pulmonary Hypertension by MIFTodd M Kolb; Fiscal Year: 2012..The pluripotential cytokine MIF (macrophage migration inhibitory factor) has described roles in regulating changes in cardiomyocyte glucose ..
- Genetic and Inflammatory Factors in Anemia in the ElderlyNancy Berliner; Fiscal Year: 2010..inflammation has also been linked with polymorphisms affecting levels of macrophage migration inhibitory factor (MIF) gene, which induces TNF...
- LPA receptor signaling in colonic epitheliaCHANGHYON CHRIS YUN; Fiscal Year: 2013..cyclin D, hypoxia-inducible factor (HIF)-1?, HIF-2?, cyclooxygenase-2, and macrophage migration inhibitory factor (MIF)...
- The role of HIF2alpha in colon carcinogenesisYatrik M Shah; Fiscal Year: 2013..3) The proinflammatory mediators, macrophage migration inhibitory factor (MIF) and prostaglandin E2 (PGE2) are early initiating factors in HIF2a-induced colon inflammation...
- Trichomonas vaginalis MIF: a role in prostate cancer and infertility?PATRICIA JEAN JOHNSON; Fiscal Year: 2013..vaginalis homologue of the inflammatory cytokine, human macrophage migration inhibitory factor (MIF). Increased level of human MIF (HuMIF) have been found in both prostate cancer and the semen of infertile men...
- AMP-activated protein kinase in the ischemic heartLawrence H Young; Fiscal Year: 2012..paradigm for AMPK activation, based on our discovery that the cytokine macrophage migration inhibitory factor (MIF) has an autocrine/paracrine effect to amplify AMPK activation during ischemia...
- Mechanism of dendritic cell differentiation in cancerDmitry I Gabrilovich; Fiscal Year: 2013..suggest that tumor-mediated defects in DC differentiation as well as accumulation of MDSC could be controlled by S100A9 protein...
- Developing Small MIF Inhibitors for Rheumatoid ArthritisChristian Grant; Fiscal Year: 2013..academic partner (The Feinstein Institute for Medical Research), targets macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine whose dysregulation underlies many autoimmune diseases...
- Role of Macrophage Migration Inhibitory Factor (MIF) in Pneumococcal PathogenesisRituparna Das; Fiscal Year: 2013..My preliminary data demonstrate an important role for macrophage migration inhibitory factor (MIF), a cytokine and upstream mediator of the innate immune response, in pneumococcal infection...
- MIF: a pro-inflammatory cytokine as a novel target to reduce bladder inflammationPedro L Vera; Fiscal Year: 2013..applicant): Experimental evidence supports the pro-inflammatory effect of Macrophage Migration Inhibitory Factor (MIF) in bladder inflammation, but how MIF mediates bladder inflammation is poorly understood...
- Paraventricular nucleus regulatory mechanisms in stress and hypertensionColin Sumners; Fiscal Year: 2013..We have recently identified macrophage migration inhibitory factor (MIF) as an intracellular negative regulator of the excitatory actions of Ang II in normotensive rat neurons...
- MIF-Thyroxine Interactions in the Pathogenesis of Pulmonary Arterial HypertensionEdmund J Miller; Fiscal Year: 2013..clinically relevant interaction between a proinflammatory cytokine [Macrophage Migration Inhibitory Factor (MIF)] and a thyroid hormone [Thyroxine (T4)] in PAH...
- Therapeutic Application of Small Molecule MIF Inhibitors in Rheumatoid ArthritisYoonsang Cho; Fiscal Year: 2013DESCRIPTION (provided by applicant): Abstract Macrophage migration inhibitory factor (MIF) plays an important role for the recruitment of innate and adaptive immune cells to the place of inflammation...
- Novel treatment strategies to regulate inflammation during P.aeruginosa keratitisMIHAELA GUEORGUIEVA GADJEVA; Fiscal Year: 2013..studies conducted during my current R21 funding period which showed that macrophage migration inhibitory factor (MIF) has an unappreciated importance in regulating innate immune responses to P...
- The Role of Macrophage Migration Inhibitory Factor in OsteoarthritisMEREDITH A GREENE; Fiscal Year: 2013..Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that has been studied for its role in the immune system and in autoimmune diseases ..
- Safe and Efficacious Oral MIF Inhibitors for Rheumatoid Arthritis TreatmentANDERSON GAWECO; Fiscal Year: 2012..Selective inhibition of macrophage migration inhibitory factor [MIF] has been target validated demonstrating unprecedented superior safety and efficacy in preclinical RA and several ..
- Molecular characterization of a hookworm Macrophage Migration Inhibitory FactorJon J Vermeire; Fiscal Year: 2010..We have identified an orthologue of the inflammatory mammalian cytokine macrophage migration inhibitory factor (MIF) from the human hookworm Ancylostoma ceylanicum...
- Role of Macrophage Migration Inhibitory Factor in OsteoclastogenesisSun Kyeong Lee; Fiscal Year: 2013..by applicant): The goal of this proposal is to examine the role of macrophage migration inhibitory factor (MIF) in the regulation of osteoclastogenesis...
- MIF: A novel CNS regulator of cardiovascular functionColin Sumners; Fiscal Year: 2013..We established previously that in normal rats MIF is an Ang II-inducible intracellular negative regulator of the AT1R mediated excitation of PVN to RVLM sympathetic ..
- The Lung as a Source of Inflammation in SepsisEdmund Miller; Fiscal Year: 2009..Macrophage migration inhibitory factor (MIF), an important mediator in sepsis, has been shown recently to be a cardiac depressant factor, and to play a ..
- Release of MIF protein complexes in vivo: response to inflammationPEDRO VERA; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Macrophage migration inhibitory factor (MIF), is a pro-inflammatory cytokine produced by the urothelium...
- Therapeutic Inhibition of MIF in Rheumatoid ArthritisKaren Anthony; Fiscal Year: 2009..RA), which will act by reducing the inflammatory response triggered by macrophage migration inhibitory factor (MIF). RA afflicts up to 4 million people in the U.S...
- HEMOZOIN AND MALARIA PATHOGENESISJAMES MARTINEY; Fiscal Year: 1999..We have preliminary data demonstrating the release of large amounts of macrophage migration inhibitory factor (MIF) by macrophages after ingestion of hemozoin or parasitized erythrocytes...
- Role of MIF in Rb inactivation and TumorigenesisRobert Mitchell; Fiscal Year: 2009..We recently discovered that the pro-inflammatory cytokine, migration inhibitory factor (MIF) is both necessary and sufficient for mitogen and oncogene-induced cyclin D1 transcription, Cdk4 activity and Rb ..
- Potential Role of H. Pylori-induced MIF in Gastric CancerELLEN BESWICK; Fiscal Year: 2009..H. pylori induces macrophage migration inhibitory factor (MIF) production from gastric epithelial cells, and MIF production is an important factor in many cancers...
- GIF regulation of B cells and CD4 cellsKatsuji Sugie; Fiscal Year: 2003..the genome and its nucleotide sequence is identical is that published for macrophage migration inhibitory factor (MIF). MIF(GIF)-/- mice show enhanced susceptibility to Leishmania major...
- MACROPHAGE PROLIFERATION AND ACTIVATIONJohn Hadden; Fiscal Year: 1980..Sephadex chromatography indicates an approximate molecular weight similar to that of migration inhibitory factor (MIF); however, vacuum dialysis prior to chromatography removes MIF and, therefore, distinguishes between the two ..
- Cytokine-HPA Interactions During PregnanacyBradley Pearce; Fiscal Year: 2006..Macrophage migration inhibitory factor (MIF) is an immunohormonal molecule that overrides the effect of cortisol on the GR...
- REGULATION OF MACROPHAGE MOTILITY BY COMPLEMENTCelso Bianco; Fiscal Year: 1980..is concerned with complement derived stimuli which induce migration or local retention and their relationship to MIF (macrophage migration inhibitory factor)...
- Neurobiology of MIF in development and diseaseBradley Pearce; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Macrophage migration inhibitory factor (MIF) is a unique molecule that functions as a cytokine and a hormone, and is induced by infections and psychological stress in animal models...
- S100A8/A9 and carboxylated N-glycans in inflammation-mediated colon cancerGEETHA K SRIKRISHNA; Fiscal Year: 2010..Calcium-binding heterodimeric proteins S100A8 and S100A9 are pro-inflammatory mediators that are also highly expressed in many tumors...
- Functional Restoration of the Optic Nerve After Disease or DamageDong Feng Chen; Fiscal Year: 2010..for the first time successful optic nerve re-elongation into the brain targets, up to postnatal day 14 (P14) in mice...
- HYPOTHALAMUS & NARCOTIC EFFECTSHEMENDRA BHARGAVA; Fiscal Year: 1992..CNS are involved in morphine tolerance-dependence and abstinence processes and (c) peptides like Pro-Leu-Gly-NH2 (MIF) and cyclo(Leu-Gly) (CLG) inhibit morphine tolerance-dependence and abstinence processes by affecting DA and opiate ..
- GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASERobert Schleimer; Fiscal Year: 2009..SPINK5 and molecules in the epidermal differentiation complex (EDC), including S100A7 (psoriasin), S100A8 and S100A9 (calgranulins A and B)...