Genomes and Genes
Gene Symbol: S100A9
Description: S100 calcium binding protein A9
Alias: 60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14, MRP-14, S100 calcium-binding protein A9 (calgranulin B), calgranulin B, calgranulin-B, calprotectin L1H subunit, leukocyte L1 complex heavy chain, migration inhibitory factor-related protein 14, protein S100-A9
Publications173 found, 100 shown here
- Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritisYueh Sheng Chen
Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia
Arthritis Res Ther 11:R39. 2009..This study evaluated the serum levels of S100A9, S100A8, S100A12 and sRAGE in RA patients, to determine their relationship to inflammation and joint and vascular ..
- Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathyKlaus Burkhardt
Nephrological Clinic Weissenburg, 91781 Weissenburg, Germany
Cardiovasc Diabetol 8:10. 2009..We investigated whether myeloid-related protein 8/14 complex (MRP8/14) secreted by transmigrating monocytes and granulocytes may represent a biomarker for microvascular alterations in patients with type 2 diabetes and nephropathy...
- S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathwaySaeid Ghavami
Manitoba Institute of Cell Biology and Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada
J Leukoc Biol 83:1484-92. 2008..RAGE small interfering RNA pretreatment abrogated the S100A8/A9-induced NF-kappaB activation. Our data indicate that S100A8/A9-promoted cell growth occurs through RAGE signaling and activation of NF-kappaB...
- Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesionCarle Ryckman
Infectious Diseases Research Center, Laval University Hospital Center, Sainte Foy, Quebec, Canada
J Immunol 170:3233-42. 2003S100A8 and S100A9 are small calcium-binding proteins that are highly expressed in neutrophil and monocyte cytosol and are found at high levels in the extracellular milieu during inflammatory conditions...
- Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancerAlexander Hermani
Research Group Hormones and Signal Transduction, German Cancer Research Center, Heidelberg, Germany
Clin Cancer Res 11:5146-52. 2005..We examined the expression of two members of this family, S100A8 and S100A9, together with the S100 receptor RAGE (receptor for advanced glycation end products) in human prostate ..
- Transendothelial migration of 27E10+ human monocytesI Eue
Institute of Experimental Dermatology, University of Munster, Von Esmarch Strasse 56, 48149 Munster, Germany
Int Immunol 12:1593-604. 2000The myeloid-related proteins MRP8 (S100A8) and MRP14 (S100A9), two members of the S100 family of calcium-binding proteins, are co-expressed and form a cell-surface and cytoskeleton-associated heterodimer upon calcium mobilization which is ..
- S100 proteins in Corpora amylacea from normal human brainD Hoyaux
Laboratory of Histopathology, Erasmus University Hospital, Faculty of Medicine, Université Libre de Bruxelles CP 620, 808 Route de Lennik, 1070, Brussels, Belgium
Brain Res 867:280-8. 2000..the presence of different S100 proteins (S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A8, S100A9, S100A12 and S100B) in C.A. from normal human brain...
- Inflammatory S100A9 and S100A12 proteins in Alzheimer's diseaseC E Shepherd
Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney 2031, Australia
Neurobiol Aging 27:1554-63. 2006..S100A8, S100A9 and S100A12 comprise a new group of inflammation-associated proteins that are constitutively expressed by ..
- The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophilsC Kerkhoff
Institut für Experimentelle Dermatologie, 48149 Munster, Germany
J Biol Chem 274:32672-9. 1999Recently, we identified the two myeloid related protein-8 (MRP8) (S100A8) and MRP14 (S100A9) as fatty acid-binding proteins (Klempt, M., Melkonyan, H., Nacken, W., Wiesmann, D., Holtkemper, U., and Sorg, C. (1997) FEBS Lett. 408, 81-84)...
- S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cellsAlexander Hermani
Research Group Hormones and Signal Transduction, German Cancer Research Centre, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Exp Cell Res 312:184-97. 2006..Deregulated expression of S100 proteins, including S100A8 and S100A9, was reported in association with neoplastic disorders...
- The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophilsR A Newton
Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, United Kingdom
J Immunol 160:1427-35. 1998..protein (MRP-14) and its heterodimeric partner, MRP-8, are members of the S100 family of calcium-binding proteins (S100A9 and S100A8, respectively)...
- Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritisMichael Frosch
Institute of Experimental Dermatology and Department of Pediatrics, University of Munster, Munster, Germany
Arthritis Rheum 48:2622-6. 2003....
- The hetero-oligomeric complex of the S100A8/S100A9 protein is extremely protease resistantWolfgang Nacken
Institute for Experimental Dermatology, University of Muenster, Roentgenstrasse 21, 48149 Muenster, Germany
FEBS Lett 581:5127-30. 2007S100A8, S100A9 and S100A12 proteins are associated with inflammation and tissue remodelling, both processes known to be associated with high protease activity...
- S100A8, S100A9 and the S100A8/A9 heterodimer complex specifically bind to human endothelial cells: identification and characterization of ligands for the myeloid-related proteins S100A9 and S100A8/A9 on human dermal microvascular endothelial cell line-1 cInes Eue
PAN Clinic, Zeppelinstrasse 1, 50667 Köln, Germany
Int Immunol 14:287-97. 2002..We demonstrate that S100A8, S100A9 and the S100A8/A9 heterodimeric complex bind to human dermal microvascular endothelial cell line (HMEC)-1 with an ..
- The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2Claus Kerkhoff
Institute of Experimental Dermatology, University of Munster, Germany
FASEB J 19:467-9. 2005..its functional relevance by the impaired oxidase activity in neutrophil-like NB4 cells, after specific blockage of S100A9 expression, and bone marrow polymorphonuclear neutrophils from S100A9-/- mice...
- Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activitySatoru Yui
Faculty of Pharmaceutical Sciences, Teikyo University, Tsukui gun, Kanagawa, Japan
Mediators Inflamm 11:165-72. 2002..of 8 and 14 kDa subunits, which have also been termed migration inhibitory factor-related proteins MRP8 and MRP14. We previously reported that rat calprotectin purified from inflammatory neutrophils induces apoptosis of various ..
- Binding of two nuclear complexes to a novel regulatory element within the human S100A9 promoter drives the S100A9 gene expressionClaus Kerkhoff
Institute of Experimental Dermatology, 48149 Muenster, Germany
J Biol Chem 277:41879-87. 2002b>S100A9, also referred to as MRP14, is a calcium-binding protein whose expression is tightly regulated during differentiation of myeloid cells...
- Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cellsDorothee Viemann
Institute of Experimental Dermatology, Integrated Functional Genomics, and the Interdisciplinary Clinical Research Center, University Hospital Muenster, University of Muenster, Röntgenstrasse 21, 48149 Muenster, Germany
Blood 105:2955-62. 2005Myeloid-related protein 8 (MRP8) and MRP14, S100 proteins secreted by activated phagocytes, bind specifically to endothelial cells. The endothelial response to MRP8/MRP14, however, is unknown...
- Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectinGerben Bouma
Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
Diabetes 53:1979-86. 2004....
- HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytesCarle Ryckman
Centre de Recherche en Infectiologie, Pavillon Centre Hospitalier de l Université Laval, Centre Hospitalier Universitaire de Quebec, and Département de Biologie Médicale, Faculte de Medecine, Universite Laval, Quebec, Canada
J Immunol 169:3307-13. 2002S100A8, S100A9, and S100A12, collectively known as myeloid-related proteins (MRPs), are highly expressed by the myeloid cell lineage and are found in the extracellular milieu during infections and inflammatory conditions...
- S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunityWolfgang Nacken
Institute of Experimental Dermatology, University of Munster, 48149 Munster, Germany
Microsc Res Tech 60:569-80. 2003..As unspecific phagocytes, they belong to the so-called innate immunity. Two S100 proteins, namely S100A9 (MRP14) and S100A8 (MRP8), constitute roughly 40% of the cytosolic protein in these cells, implying by their pure ..
- S100A8 and S100A9 in human arterial wall. Implications for atherogenesisMichelle M McCormick
School of Medical Sciences, St Vincent s Hospital, University of New South Wales, Sydney, Australia
J Biol Chem 280:41521-9. 2005Atherogenesis is a complex process involving inflammation. S100A8 and S100A9, the Ca2+-binding neutrophil cytosolic proteins, are associated with innate immunity and regulate processes leading to leukocyte adhesion and transmigration...
- Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activityNadja Leukert
Institute of Experimental Dermatology, University of Muenster, Roentgenstr 21, 48149 Muenster, Germany
J Mol Biol 359:961-72. 2006..The heterodimers of S100A8 and S100A9 represent the major calcium-binding proteins in phagocytes...
- Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiationE Lagasse
Department of Biotechnology, Ciba Geigy, Basel, Switzerland
Mol Cell Biol 8:2402-10. 1988..Two proteins, MRP8 and MRP14, which are expressed in infiltrate macrophages during inflammatory reactions but not in normal tissue macrophages, ..
- Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cationsThomas Vogl
Institute of Experimental Dermatology, University of Muenster, Roentgenstrasse 21, 48149 Muenster, Germany
Biochim Biophys Acta 1763:1298-306. 2006S100A8 and S100A9 are two proinflammatory molecules belonging to the S100 family of calcium-binding proteins...
- Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expressionJens Grote
Institute of Experimental Dermatology, University of Muenster, Germany
BMC Mol Biol 7:48. 2006..Dysregulated expression of S100 proteins, including S100A9, has been reported in the epidermis as a response to stress and in association with neoplastic disorders...
- TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteinsPooja Pungaliya
Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08901, USA
J Proteome Res 6:3918-23. 2007..Transfection studies confirmed mammalian Sin3A as a sumoylation substrate for TOPORS. These findings suggest that TOPORS may function as a tumor suppressor by regulating mSin3A and other proteins involved in chromatin modification...
- Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end productsPhilipp Ehlermann
Universitat Heidelberg, Abteilung Innere Medizin III, Heidelberg, Germany
Cardiovasc Diabetol 5:6. 2006..As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression.
- Up-regulation of metastasis-promoting S100A4 (Mts-1) in rheumatoid arthritis: putative involvement in the pathogenesis of rheumatoid arthritisJorg Klingelhofer
Danish Cancer Society, Copenhagen, Denmark
Arthritis Rheum 56:779-89. 2007..To examine the involvement of the metastasis-inducing protein S100A4 (Mts-1) in the pathogenesis of rheumatoid arthritis (RA)...
- Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)C Kerkhoff
Institut für Experimentelle Dermatologie, Munster, Germany
Biochim Biophys Acta 1448:200-11. 1998The two migration inhibitory factor- (MIF)-related protein-8 (MRP8; S100A8) and MRP14 (S100A9) are two calcium-binding proteins of the S100 family...
- The S100 family of EF-hand calcium-binding proteins: functions and pathologyB W Schafer
Department of Pediatrics, University of Zurich, Switzerland
Trends Biochem Sci 21:134-40. 1996..Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging...
- Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritisK Odink
Department of Biotechnology, Ciba Geigy, Basel, Switzerland
Nature 330:80-2. 1987..Characterization of MRP-8 and MRP-14 could therefore be useful to the understanding of cellular processes induced in chronic inflammation...
- Myeloid related protein-8/14 stimulates interleukin-8 production in airway epithelial cellsAli Ahmad
Respiratory Research Laboratory, Department of Medicine, University of Birmingham, Birmingham B15 2TT, UK
Am J Respir Cell Mol Biol 29:523-30. 2003....
- The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritisKatsue Sunahori
Department of Medicine and Clinical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
Arthritis Res Ther 8:R69. 2006S100A8 and S100A9, two Ca2+-binding proteins of the S100 family, are secreted as a heterodimeric complex (S100A8/A9) from neutrophils and monocytes/macrophages...
- Biochemical characterization of the murine S100A9 (MRP14) protein suggests that it is functionally equivalent to its human counterpart despite its low degree of sequence homologyW Nacken
Institute of Experimental Dermatology, University of Munster, Germany
Eur J Biochem 267:560-5. 2000Due to the low degree of sequence similarity it has been speculated that murine and human S100A9 (MRP14), an inflammatory marker protein belonging to the S100 protein family, may have different cellular functions in mouse and man...
- S100A8 and S100A9 in experimental osteoarthritisHala Zreiqat
Tissue Engineering and Biomaterials Research Unit, School of AMME J07, Faculty of Engineering, Bosch Institute, University of Sydney, Corner of Shepherd and Cleavland Street, New South Wales 2006, Australia
Arthritis Res Ther 12:R16. 2010The objective was to evaluate the changes in S100A8 S100A9, and their complex (S100A8/S100A9) in cartilage during the onset of osteoarthritis (OA) as opposed to inflammatory arthritis.
- Immunohistochemical investigation of S100A9 expression in pulmonary adenocarcinoma: S100A9 expression is associated with tumor differentiationK Arai
Department of Pathology, Shizuoka General Hospital, Shizuoka 420 0881, Japan
Oncol Rep 8:591-6. 2001..However, there have been few studies on S100A9 in specific types of carcinomas, except for squamous cell carcinoma (SCC) because the expression in normal ..
- Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitroMarie Pierre Manitz
Institute of Experimental Dermatology, Zentrum fur Molekularbiologie der Entzundung, Univeristy of Münster, 48149 Munster, Germany
Mol Cell Biol 23:1034-43. 2003The S100A9 (MRP14) protein is abundantly expressed in myeloid cells and has been associated with various inflammatory diseases. The S100A9-deficient mice described here were viable, fertile, and generally of healthy appearance...
- An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swineT Lewis
Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Greenport, New York 11944 0848, USA
J Virol 74:1275-85. 2000..Time course analysis and viral DNA synthesis inhibitor experiments indicated that p14 was a late viral protein...
- Immunopathogenic mechanisms in hypertensionN Lefkos
Cardiology Unit, Aristotle University of Thessaloniki, Hippokration Hospital, Greece
Am J Hypertens 8:1141-5. 1995..immunity against arterial wall antigen was studied in all subjects by means of migration inhibitory factor (MIF) against relevant antigen preparation...
- Vascular actions of thrombin receptor-derived polypeptides: structure-activity profiles for contractile and relaxant effects in rat aortaA A Laniyonu
Department of Pharmacology and Therapeutics, University of Calgary, Faculty of Medicine, AB Canada
Br J Pharmacol 114:1680-6. 1995..Rat P5-NH2), SFLLRNP (P7), SFLLRNP-NH2 (P7-NH2), SFFLRNP (Rat P7), SFFLRNP-NH2 (Rat P7-NH2), and SFLLRNPNDKYEPF (P14). 2...
- Granulomatous slack skin in childhoodF M Camacho
Department of Medical-Surgical Dermatology, Hospital Universitario Virgen Macarena, Universidad de Sevilla, Spain
Pediatr Dermatol 14:204-8. 1997..The phenotype of the giant cells was lysozyme positive, CD68+ and Mac387-...
- Side effects of antibiotics on immune response parameters and their possible implications in antimicrobial chemotherapyG Gillissen
Institute of Medical Microbiology, Medical Faculty, , Aachen
Zentralbl Bakteriol Mikrobiol Hyg A 270:171-99. 1988..g. foodpad swelling reaction, MIF-production, mitogen/antigen induced lymphocyte proliferation and delayed type hypersensitivity skin reaction), on ..
- The monocyte/macrophage infiltrate in 35 medulloblastomas: a paraffin-wax studyM L Rossi
Department of Neuropathology, Midland Centre for Neurosurgery and Neurology, Birmingham, United Kingdom
Tumori 77:36-40. 1991..tissue from 35 medulloblastomas, collected over 23 years (27 non-desmoplastic and 8 desmoplastic) with KP1 and Mac387 two monoclonal anti-monocytes/macrophage (M/Ms) antibodies recommended for use on paraffin wax embedded tissue...
- Effect of vitamin E on production of macrophage migration inhibitory factor (MIF) by macrophagesW Sakamoto
Department of Biochemistry, School of Dentistry, Hokkaido University, Sapporo, Japan
Biofactors 10:139-43. 1999Macrophage migration inhibitory factor (MIF), a putative cytokine involved in inflammatory and immune responses, was identified in rat peritoneal macrophages by Western blot analysis and its secretion into culture medium by enzyme-linked ..
- [Studies on transference of hydrogenase genes of Rhizobium arachis]Z Wang
Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
Wei Sheng Wu Xue Bao 41:421-6. 2001The hydrogen-uptake genes were transferred into wild Rhizobium arachis Ra strains (Hup-, Nif+, Apr) by triparental mating using pRK2013 as help plasmid. A transconjugant R...
- A heterocomplex formed by the calcium-binding proteins MRP8 (S100A8) and MRP14 (S100A9) binds unsaturated fatty acids with high affinityG Siegenthaler
Clinique de Dermatologie, Hopital Cantonal Universitaire, CH 1211 Geneve 14, Switzerland
J Biol Chem 272:9371-7. 1997..by the non-covalent association of two calcium-binding proteins of the S100 family: MRP8 (S100A8) and MRP14 (S100A9). Fatty acid-competition studies on the [3H]oleic acid...
- [A case of fulminant psittacosis necessitating mechanical ventilation diagnosed by chlamydial isolation form BALF]H Taniguchi
Third Department of Internal Medicine, Miyazaki Medical College, Japan
Kansenshogaku Zasshi 69:1396-401. 1995..diagnosis was established with a significant rise of both IgG and IgM antibody against Chlamydia psittaci with MIF and identification of Chlamydia with the cell culture method...
- Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cellsTadamichi Shimizu
Departments of Dermatology and Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
J Biol Chem 279:13729-37. 2004Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has been shown to play a role in wound-healing processes...
- Association of interindividual differences in p14ARF promoter methylation with single nucleotide polymorphism in primary colorectal cancerMi Yeon Kang
Center for Genome Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Kangnam Ku, Seoul, South Korea
Cancer 112:1699-707. 2008..The objective of the current study was to understand whether single nucleotide polymorphisms (SNPs) around the promoter of a gene are implicated in the interindividual differences of CpG island hypermethylation...
- Long-term effect of nifedipine and hydrochlorothiazide on blood pressure and sodium homeostasis at varying levels of salt intake in mildly hypertensive patientsF C Luft
Department of Internal Medicine-Nephrology, , Germany
Am J Hypertens 4:752-60. 1991To elucidate and compare the effects of nifedipine (NIF) and hydrochlorothiazide (HCTZ) on blood pressure (BP) and sodium (Na) balance, we conducted a randomized, double-blind, crossover study with 50 mg/day HCTZ and 90 mg/day NIF (as ..
- [Spontaneous cure of pneumonia caused by Chlamydia pneumoniae]N Miyashita
Department of Medicine, Kawasaki Medical School
Kansenshogaku Zasshi 69:934-9. 1995..512-fold in the acute phase and decreased to 32-fold in the convalescent phase using the micro-immunofluorescence (MIF) test, indicating a C. pneumoniae acute infection. In fact, no other micro-organisms were detected...
- Xefiltin, a new low molecular weight neuronal intermediate filament protein of Xenopus laevis, shares sequence features with goldfish gefiltin and mammalian alpha-internexin and differs in expression from XNIF and NF-LY Zhao
Department of Biological Sciences, University at Albany, State University of New York 12222, USA
J Comp Neurol 377:351-64. 1997..mammals, the progressive maturation of neurons is marked by successive changes in neuronal intermediate filament (nIF) subunit composition...
- Increase in macrophage migration inhibitory factor levels in lacrimal fluid of patients with severe atopic dermatitisNobuyoshi Kitaichi
Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, 060 8638, Sapporo, Japan
Graefes Arch Clin Exp Ophthalmol 244:825-8. 2006..Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is associated with the generation of cell-mediated immune responses...
- Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infectionChristian Østergaard
Department of Clinical Microbiology, Copenhagen University Hospital Herlev, Herlev Ringvej, DK 2730 Herlev, Denmark
Crit Care 13:R101. 2009Macrophage migration inhibitory factor (MIF) plays an essential pathophysiological role in septic shock, but its role in central nervous system infection (CNS) remains to be defined.
- [A child with iritis due to Chlamydia pneumoniae infection]S Yamada
Department of Pediatrics, Kurume University School of Medicine
Kansenshogaku Zasshi 68:1543-7. 1994..pneumoniae infection was made by specific polymerase chain reaction (PCR) method and microimmunofluorescence test (MIF). The symptoms subsided with administration of clarithromycin (CAM: 300 mg/day) for 2 weeks...
- Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathyY G Kim
Division of Nephrology, University of Washington Medical Center, Seattle, USA
Mol Med 6:837-48. 2000..We hypothesized that uric acid crystal deposition may induce granuloma formation by stimulating local expression of macrophage migration inhibitory factor (MIF), which is a known mediator of delayed type hypersensitivity (DTH).
- The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteinsIngo P Korndörfer
Lehrstuhl fur Biologische Chemie, Technische Universitat Munchen, Freising Weihenstephan, Germany
J Mol Biol 370:887-98. 2007The EF-hand proteins S100A8 and S100A9 are important calcium signalling proteins that are involved in wound healing and provide clinically relevant markers of inflammatory processes, such as rheumatoid arthritis and inflammatory bowel ..
- The cytokine macrophage migration inhibitory factor reduces pro-oxidative stress-induced apoptosisMai Tuyet Nguyen
Laboratory of Biochemistry, Institute for Interfacial Engineering, University of Stuttgart and Fraunhofer Institut für Grenzflächen und Bioverfahrenstechnik, Stuttgart, Germany
J Immunol 170:3337-47. 2003The cytokine macrophage migration inhibitory factor (MIF) exhibits pro- and anti-inflammatory activities and regulates cell proliferation and survival. We investigated the effects of MIF on apoptosis...
- Nonintracranial fatal firearm injuries in children: implications for treatmentMichael L Nance
Department of Surgery, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Trauma 55:631-5. 2003Understanding the injury characteristics of nonintracranial fatal (NIF) gunshot wounds in children treated in a statewide trauma system will help guide effective treatment strategies.
- Interferon-tau stimulates secretion of macrophage migration inhibitory factor from bovine endometrial epithelial cellsBingtuan Wang
Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec J2S 7C6, Canada
Biol Reprod 69:1690-6. 2003..12-kDa protein contained a partial amino acid sequence that corresponded to macrophage migration inhibitory factor (MIF)...
- A switch in the cellular localization of macrophage migration inhibitory factor in the rat testis after ethane dimethane sulfonate treatmentA Meinhardt
Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
J Cell Sci 112:1337-44. 1999Macrophage migration inhibitory factor (MIF), one of the first cytokines to be discovered, has recently been localized to the Leydig cells in adult rat testes...
- High expression of myeloid-related proteins 8 and 14 characterizes an inflammatorily active but ineffective response of macrophages during leprosyCord H Sunderkötter
Institute of Experimental Dermatology, University of Munster, Munster, Germany
Immunology 111:472-80. 2004..Expression and release of the myeloid-related protein (MRP) 8 and MRP14 (S100A8 and S100A9) characterize a proinflammatory subtype of macrophage that is prominent in, for example, murine infection with ..
- Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitisYoshitaka Sakai
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
Gastroenterology 124:725-36. 2003Macrophage migration inhibitory factor (MIF), originally described as an inhibitor of the random migration of macrophages, has been shown recently to be involved in the pathogenesis of several inflammatory diseases such as sepsis...
- Soluble components of Histoplasma capsulatum var. capsulatum have hemagglutinin activity and induce syngeneic hemophagocytosis in vitroR H F Vivan
Departamento de Ciências Patológicas, CCB, Universidade Estadual de Londrina, Campus Universitario, Londrina, PR, 86051 970, Brazil
Mycopathologia 169:151-7. 2010..activity, mouse red blood cells (RBC) (1% v/v in PBS) were incubated (37 degrees C, 1 h) with cell-free antigen (CFAg) from H. capsulatum var...
- Oxidation of methionine 63 and 83 regulates the effect of S100A9 on the migration of neutrophils in vitroHerve Y Sroussi
Department of Oral Medicine, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7213, USA
J Leukoc Biol 81:818-24. 2007The calcium-binding proteins S100A8 and S100A9 and their heterocomplex calprotectin are abundant cytosolic constituents in human neutrophils, constitutively expressed by mucosal epithelium and in association with inflammation by epidermal ..
- Dermal dendrocytes in Dupuytren's disease: a link between the skin and pathogenesis?P Sugden
Department of Pathological Sciences, University of Manchester, Salford, UK
J Hand Surg Br 18:662-6. 1993..Immunohistochemistry was performed using a panel of antibodies for factor XIIIa, macrophages (CD68 and MAC387) and MHC II...
- [Role of macrophage migration inhibitory factor in septic shock-induced cardiovascular dysfunction: experiment with rats]Fu Zhou Wang
Department of Anesthesia, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China
Zhonghua Yi Xue Za Zhi 87:768-73. 2007To investigate the role of macrophage migration inhibitory factor (MIF) in septic shock-induced cardiovascular dysfunction.
- Differential metabolism of Tyr-MIF-1 and MIF-1 in rat and human plasmaA J Kastin
VA Medical Center, New Orleans, LA
Biochem Pharmacol 47:699-709. 1994The metabolism of the endogenous brain peptides Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) and MIF-1 (Pro-Leu-Gly-NH2) was determined by HPLC after incubation of the tritiated peptides in human and rat plasma...
- Substance P induces localization of MIF/alpha1-inhibitor-3 complexes to umbrella cells via paracellular transit through the urothelium in the rat bladderPedro L Vera
The Bay Pines VA Healthcare System, Research and Development, Bay Pines, FL, USA
BMC Urol 6:24. 2006Macrophage migration inhibitory factor (MIF) is released into the intraluminal fluid during bladder inflammation in the rat complexed to alpha1-inhibitor-3 (A1-I3; a rodent proteinase inhibitor in the alpha-macroglobulin family)...
- Effects of Tyr-MIF's family of peptides on immobilization stress-induced antinociception in ratsAdriana I Bocheva
Institute of Physiology, Bulgarian Academy of Sciences, Sofia
Folia Med (Plovdiv) 46:42-6. 2004The Tyr-MIF-1 family of peptides includes MIF-1, Tyr-MIF-1, Tyr-W-MIF-1 and Tyr-K-MIF-1, which have been isolated from bovine hypothalamus and cortex of human brain...
- Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factorSusannah K Leaver
Unit of Critical Care, Respiratory Science, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW3 6LY, UK
Intensive Care Med 36:336-41. 2010To establish the relationship between plasma levels of thioredoxin (Trx) and macrophage migration inhibitory factor (MIF) in systemic inflammatory stress syndrome (SIRS)/sepsis.
- Tyr-MIF-1 attenuates development of tolerance to spiperone-induced catalepsy in ratsR M Kostrzewa
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City 37614
Brain Res Bull 31:707-12. 1993Because the tripeptide MIF-1 (Pro-Leu-Gly-NH2) is known to attenuate the effects of neuroleptic-induced catalepsy as well as neuroleptic-induced proliferation of dopamine (DA) receptors, we studied the related naturally occurring peptide,..
- Role of macrophage migration inhibitory factor (MIF) in peripheral nerve regeneration: anti-MIF antibody induces delay of nerve regeneration and the apoptosis of Schwann cellsYasuhiko Nishio
Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Mol Med 8:509-20. 2002Macrophage migration inhibitory factor (MIF) is a pluripotent cytokine involved in inflammation and immune responses as well as in cell growth...
- Upregulation of macrophage migration inhibitory factor (MIF) and CD74, receptor for MIF, in rat bladder during persistent cyclophosphamide-induced inflammationPedro L Vera
Bay Pines VA Healthcare System, Research and Development 151, 10000 Bay Pines Boulevard, Bay Pines, FL 33744, USA
Exp Biol Med (Maywood) 233:620-6. 2008The objective of this study was to determine if macrophage migration inhibitory factor (MIF) is upregulated in the bladder during persistent cystitis. MIF is a pro-inflammatory cytokine found pre-formed in the urothelium...
- Up-regulation of macrophage migration inhibitory factor in infants with acute neonatal necrotizing enterocolitisY Ren
Department orf Surgery, University of Hong Kong, Hong Kong SAR, China
Histopathology 46:659-67. 2005To investigate the role of macrophage migration inhibitory factor (MIF) and its downstream cytokine cascade in necrotizing enterocolitis (NEC).
- Macrophage migration inhibitory factor up-regulates the expression of interleukin-8 messenger RNA in synovial fibroblasts of rheumatoid arthritis patients: common transcriptional regulatory mechanism between interleukin-8 and interleukin-1betaShin Onodera
Department of Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
Arthritis Rheum 50:1437-47. 2004..This study was undertaken to investigate the IL-8 inductive activity of the macrophage migration inhibitory factor (MIF) in RA synovial fibroblasts. The regulatory mechanism of IL-8 was compared with that of IL-1beta.
- Urine macrophage migration inhibitory factor (MIF) in children with urinary tract infection: a possible predictor of acute pyelonephritisHasan Otukesh
Urology and Nephrology Research Center, Labbafi Nejad Hospital, Tehran, Iran
Pediatr Nephrol 24:105-11. 2009Macrophage migration inhibitory factor (MIF) is an important pro-inflammatory cytokine expressed at sites of inflammation...
- Isolation of the murine S100 protein MRP14 (14 kDa migration-inhibitory-factor-related protein) from activated spleen cells: characterization of post-translational modifications and zinc bindingM J Raftery
Immunology Group, Heart Research Institute, Camperdown, New South Wales, Australia
Biochem J 316:285-93. 1996b>MRP14 (macrophage migration-inhibitory factor-related protein of molecular mass 14 kDa) is an S100 calcium binding protein constitutively expressed in human neutrophils which may be associated with cellular activation/inflammation...
- Up-regulated macrophage migration inhibitory factor protects apoptosis of dermal fibroblasts in patients with systemic sclerosisJ Y Kim
Division of Rheumatology, Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul, South Korea
Clin Exp Immunol 152:328-35. 2008Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that has been demonstrated to regulate the apoptosis of several cell types...
- Macrophage migration inhibitory factor is critical to interleukin-5-driven eosinophilopoiesis and tissue eosinophilia triggered by Schistosoma mansoni infectionElizabeth S Magalhães
Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
FASEB J 23:1262-71. 2009Macrophage migration inhibitory factor (MIF) participates in the pathogenesis of inflammatory diseases, including asthma, in which it enhances airway hypersensitivity and tissue eosinophilia...
- Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the ratPedro L Vera
The Bay Pines VA Healthcare System, Research and Development, Bay Pines, Florida, United States of America
PLoS ONE 4:e5835. 2009Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine constitutively expressed by urothelial cells...
- Organization and expression of nitrogen-fixation genes in the aerobic nitrogen-fixing unicellular cyanobacterium Synechococcus sp. strain RF-1T C Huang
Institute of Botany, Academia Sinica, Taipei, Taiwan, Republic of China
Microbiology 145:743-53. 1999Sixteen nif and 'nif-associated' genes (expressed only under conditions of nitrogen fixation) in Synechococcus sp. strain RF-1 have been cloned and sequenced...
- Serum macrophage migration inhibitory factor reflects adrenal function in the hypothalamo-pituitary-adrenal axis of septic patients: an observational studyTakashi Miyauchi
Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
BMC Infect Dis 9:209. 2009..Macrophage migration inhibitory factor (MIF), which counteracts the anti-inflammatory activity of glucocorticoid (GC), is one of the mediators of the ..
- Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female ratEric Houdeau
Neuro Gastroenterology and Nutrition Unit, Institut National de la Recherche Agronomique, Toulouse, France
Gastroenterology 132:982-93. 2007Sex steroids influence IBD symptoms. Macrophage migration inhibitory factor (MIF), a target of sex steroids in other inflammatory models, promotes interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha release in colitis...
- Macrophage migration inhibitory factor expression and protein localization in Amblyomma americanum (Ixodidae)C J Bowen
Department of Entomology and Plant Pathology, Oklahoma State University, 127 Noble Research Center, Stillwater, OK 74078 8031, USA
Exp Appl Acarol 50:343-52. 2010..Tick macrophage migration inhibitory factor (MIF) was first identified in A...
- Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr miceAlberta Y Hoi
Department of Medicine, Centre for Inflammatory Diseases, Monash Institute of Medical Research, Monash University, Melbourne, Australia
J Immunol 177:5687-96. 2006..Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is operative in innate and adaptive immunity and important in immune-mediated ..
- The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factorFarah El-Turk
Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
Biochemistry 47:10740-56. 2008Macrophage migration inhibitory factor (MIF) is a multifunctional protein and a major mediator of innate immunity...
- Profiles of the 2 INK4a gene products, p16 and p14ARF, in human reference urothelium and bladder carcinomas, according to pRb and p53 protein statusMarie Aude Le Frere-Belda
Service d Anatomie et de Cytologie Pathologiques and Oncogénèse respiratoire et uro génitale EMI Institut National de la Santé de la Recherche Medical INSERM, Centre Hospitalier Universitaire Henri Mondor, Creteil, France
Hum Pathol 35:817-24. 2004The INK4a/ARF locus encodes 2 cell cycle regulatory proteins: p16 and p14(ARF). P16 inhibits the activities of cdks, which maintain the retinoblastoma protein (pRb) in its active hypophosphorylated state...
- The calcium binding protein S100A9 is essential for pancreatic leukocyte infiltration and induces disruption of cell-cell contactsJurgen Schnekenburger
Department of Medicine B, Westfalische Wilhelms University, Munster, Germany
J Cell Physiol 216:558-67. 2008..Here, we studied the role of S100A9 (MRP14), a calcium binding protein specifically released by polymorph nuclear leukocytes (PMN), in the course of ..
- Macrophage migration inhibitory factor and host innate immune responses to microbesThierry Calandra
Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Scand J Infect Dis 35:573-6. 2003..Recently, the protein known as macrophage migration inhibitory factor (MIF) has emerged as a pivotal mediator of innate immunity...
- Elevated macrophage migration inhibitory factor (MIF) is associated with depressive symptoms, blunted cortisol reactivity to acute stress, and lowered morning cortisolKate M Edwards
Department of Psychiatry, UCSD Medical Center, University of California San Diego, La Jolla, CA, USA
Brain Behav Immun 24:1202-8. 2010Macrophage Migration Inhibitory Factor (MIF) is a proinflammatory cytokine produced by leukocytes and the secretory cells of the HPA axis...
- Complex assembly mechanism and an RNA-binding mode of the human p14-SF3b155 spliceosomal protein complex identified by NMR solution structure and functional analysesKanako Kuwasako
Protein Research Group, RIKEN Genomic Sciences Center, Yokohama 230 0045, Japan
Proteins 71:1617-36. 2008The spliceosomal protein p14, a component of the SF3b complex in the U2 small nuclear ribonucleoprotein (snRNP), is essential for the U2 snRNP to recognize the branch site adenosine...
- IFN-gamma promotes Fas ligand- and perforin-mediated liver cell destruction by cytotoxic CD8 T cellsEvelyn Roth
Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
J Immunol 172:1588-94. 2004To study liver cell damage by CTL, CD8 T cells from P14 TCR transgenic (tg) mice specific for the gp33 epitope of lymphocytic choriomeningitis virus with either deficiency in IFN-gamma (P14.IFN-gamma(null)), functional Fas ligand (P14...
- IscA, an alternate scaffold for Fe-S cluster biosynthesisC Krebs
Department of Physics, Emory University, Atlanta, Georgia 30322, USA
Biochemistry 40:14069-80. 2001An IscA homologue within the nif regulon of Azotobacter vinelandii, designated (Nif)IscA, was expressed in Escherichia coli and purified to homogeneity...
- An immunohistochemical study of the ontogeny of the horizontal cell in the rat retina using an antiserum against spot 35 protein, a novel Purkinje cell-specific protein, as a markerH Kondo
Department of Anatomy, School of Medicine, Kanazawa University, Japan
Anat Rec 222:103-9. 1988..At P14 all the immunoreactive horizontal cells extended their processes horizontally to form a tight bundle all the way ..
- A Tyr-W-MIF-1 analog containing D-Pro2 discriminates among antinociception in mice mediated by different classes of mu-opioid receptorsDaisuke Nakayama
Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
Eur J Pharmacol 563:109-16. 2007The antagonism by Tyr-D-Pro-Trp-Gly-NH2 (D-Pro2-Tyr-W-MIF-1), a Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1) analog, of the antinociception induced by the mu-opioid receptor agonists Tyr-W-MIF-1, [D-Ala2,NMePhe4,Gly(ol)5]-enkephalin (DAMGO), Tyr-..
- Urinary macrophage migration inhibitory factor in children with urinary tract infectionEsra Sevketoglu
Department of Pediatrics, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey
Pediatr Nephrol 25:299-304. 2010Macrophage migration inhibitory factor (MIF) plays an essential pathophysiological role in inflammatory reactions...
- Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metforminParesh Dandona
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
J Clin Endocrinol Metab 89:5043-7. 2004The objective of the study was to determine whether plasma migration inhibitor factor (MIF) concentration and mononuclear cell (MNC) mRNA are elevated in obesity and whether treatment with metformin reduces plasma MIF concentration...
- [A case of adult Chlamydia pneumoniae pneumonia diagnosed from a culture method]H Chikumi
Third Department of Internal Medicine, Faculty of Medicine, Tottori University
Kansenshogaku Zasshi 68:407-10. 1994..We changed the treatment by using 300 mg of roxithromycin per day and these symptoms disappeared. To diagnose C. pneumoniae early, PCR, MIF and culture methods are very useful diagnostic tools.
- Urine macrophage migration inhibitory factor reflects the severity of renal injury in human glomerulonephritisFiona G Brown
Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia
J Am Soc Nephrol 13:S7-13. 2002Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays a pathogenic role in experimental crescentic glomerulonephritis (GN)...
- CREB Regulates Adipogenesis and Adipocyte SurvivalDwight J Klemm; Fiscal Year: 2010..also increases expression of intercellular adhesion molecule-1 (ICAM-1), macrophage migration inhibitory factor-1 (MIF-1), macrophage colony stimulating factor-1 (MCSF-1), CXC ligand 13, stromal cell-derived factors -1 (SDF-1) and ..
- Innate and Adaptive Immune Mechanisms in ArthritisRICHARD J BUCALA; Fiscal Year: 2010..Since our initial cloning of murine macrophage migration inhibitory factor (MIF), we have focused on the role of this mediator in the pathogenesis of rheumatoid arthritis...
- Innate and Adaptive Immune Mechanisms in ArthritisRichard Bucala; Fiscal Year: 2009..Since our initial cloning of murine macrophage migration inhibitory factor (MIF), we have focused on the role of this mediator in the pathogenesis of rheumatoid arthritis...
- Paraventricular nucleus regulatory mechanisms in stress and hypertensionCOLIN contact SUMNERS; Fiscal Year: 2010..We have recently identified macrophage migration inhibitory factor (MIF) as an intracellular negative regulator of the excitatory actions of Ang II in normotensive rat neurons...
- Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail ElderlyGeorge Kuchel; Fiscal Year: 2007..We propose that an atypical cytokine called MIF (macrophage migration inhibitory factor) is involved in the pathways by which urinary retention promotes muscle ..
- Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail ElderlyGeorge A Kuchel; Fiscal Year: 2010..We propose that an atypical cytokine called MIF (macrophage migration inhibitory factor) is involved in the pathways by which urinary retention promotes muscle ..
- Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail ElderlyGeorge Kuchel; Fiscal Year: 2009..We propose that an atypical cytokine called MIF (macrophage migration inhibitory factor) is involved in the pathways by which urinary retention promotes muscle ..
- Role of Cysteine Proteases in Atherosclerosis & AneurysmGuo Ping Shi; Fiscal Year: 2007..By contrast, the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) is highly expressed in these lesions as well as in sera from patients with AAA...
- The Lung as a Source of Inflammation in SepsisEdmund Miller; Fiscal Year: 2009..Macrophage migration inhibitory factor (MIF), an important mediator in sepsis, has been shown recently to be a cardiac depressant factor, and to play a ..
- The Lung as a Source of Inflammation in SepsisEdmund Miller; Fiscal Year: 2007..Macrophage migration inhibitory factor (MIF), an important mediator in sepsis, has been shown recently to be a cardiac depressant factor, and to play a ..
- Release of MIF protein complexes in vivo: response to inflammationPEDRO VERA; Fiscal Year: 2007Macrophage migration inhibitory factor (MIF), is a pro-inflammatory cytokine produced by the urothelium...
- INNATE AND ADAPTIVE MECHANISMS IN ARTHRITISRichard Bucala; Fiscal Year: 2007..Macrophage migration inhibitory factor (MIF) is an upstream regulator of the immune response that is produced both by innate (monocyte/macrophage) and adaptive ..
- MIF AND THE HOST RESPONSE TO INFECTIONRICHARD J BUCALA; Fiscal Year: 2010..In 1993, we cloned murine macrophage migration inhibitory factor (MIF) as an upstream regulator of innate immunity and mediator of lethal shock...
- MIF AND THE HOST RESPONSE TO INFECTIONRichard Bucala; Fiscal Year: 2007..We have discovered that macrophage migration inhibitory factor (MIF) is an important mediator of innate immunity and upstream regulator of inflammatory cytokine production...
- Amplification of tumor hypoxic responses by MIF-dependent HIF stabilizationRobert A Mitchell; Fiscal Year: 2010..We recently discovered that macrophage migration inhibitory factor (MIF), one of the oldest cytokines ever described, is elevated in PDAC patient's plasma and induced by hypoxia-..
- Mechanisms of Rheumatoid Synovial Fibroblast ActivationRichard Bucala; Fiscal Year: 2006..The central hypothesis is that the cytokine, macrophage migration inhibitory factor (MIF), induces sustained ERK-1/2 activation, invasive phenotype, and suppression of p53-dependent apoptosis in synovial ..
- Functional and Structural Studies of CD74 ActivationElias Lolis; Fiscal Year: 2010..CD74 has been identified as a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF). MIF is a pro-inflammatory protein that is secreted by cells upon exposure to microbes or their products...
- Functional and Structural Studies of CD74 ActivationElias Lolis; Fiscal Year: 2007..CD74 has been identified as a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF). MIF is a pro-inflammatory protein that is secreted by cells upon exposure to microbes or their products...
- MIF AND THE HOST RESPONSE TO INFECTIONRichard Bucala; Fiscal Year: 2002..Recent work has led to the concept that the mediator macrophage migration inhibitory factor ( MIF ) can act as a physiological counter-regulator of glucocorticoid action within the immune system...
- Mechanism of dendritic cell differentiation in cancerDmitry Gabrilovich; Fiscal Year: 2009..suggest that tumor-mediated defects in DC differentiation as well as accumulation of MDSC could be controlled by S100A9 protein...
- Mechanism of dendritic cell differentiation in cancerDMITRY ISAAC GABRILOVICH; Fiscal Year: 2010..suggest that tumor-mediated defects in DC differentiation as well as accumulation of MDSC could be controlled by S100A9 protein...
- Role of Epithelium in Immunity, Inflammation and DiseaseRobert P Schleimer; Fiscal Year: 2010..impairment in the expression of the important antimicrobial peptides psoriasin (S100A7) and calprotectin (S100A8/S100A9) in the epithelium of patients with CRS, suggesting diminished innate immune host defense...
- Functional Restoration of the Optic Nerve After Disease or DamageDong Feng Chen; Fiscal Year: 2010..for the first time successful optic nerve re-elongation into the brain targets, up to postnatal day 14 (P14) in mice...
- Functional Restoration of the Optic Nerve After Disease or DamageDong Chen; Fiscal Year: 2009..for the first time successful optic nerve re-elongation into the brain targets, up to postnatal day 14 (P14) in mice...
- MIDBRAIN CIRCUITRY FOR NEURONAL CONTROL OF GAZEPaul J May; Fiscal Year: 2010..The preganglionic and MIF motor neuron groups are found in the perioculomotor region...
- Biosynthesis and Novel Function of Fe-S clustersBoi Hanh Huynh; Fiscal Year: 2007..At present, there are three known Fe-S cluster biosynthesis machineries: the nitrogen fixation specific NIF system, the ubiquitous "housekeeping" iron-sulfur cluster assembly ISC system, and the newly discovered "sulfur ..
- GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASERobert Schleimer; Fiscal Year: 2009..SPINK5 and molecules in the epidermal differentiation complex (EDC), including S100A7 (psoriasin), S100A8 and S100A9 (calgranulins A and B)...
- The temporal epigenomic program of Barrett's neoplastic progressionStephen J Meltzer; Fiscal Year: 2010..Tumor suppressor genes affected by hypermethylation at various stages of BN include p16, p14, E-cadherin, APC, and others...
- The temporal epigenomic program of Barrett's neoplastic progressionStephen Meltzer; Fiscal Year: 2009..Tumor suppressor genes affected by hypermethylation at various stages of BN include p16, p14, E-cadherin, APC, and others...
- Neurological and Cognitive Outcomes Following CAGBGUY MC KHANN; Fiscal Year: 2007..Specific Aim 3: To develop a statistical model that predicts cognitive change in CABG and/or other populations at risk for cerebrovascular disease over the 5-year follow-up period. ..
- DEVELOPMENTAL GENOME REARRANGEMENT OF NIF GENESJames Golden; Fiscal Year: 2002..Additionally, three programmed site-specific DNA rearrangements that remove DNA elements from nif and hup genes occur in heterocysts...