Gene Symbol: S100A7A
Description: S100 calcium binding protein A7A
Alias: NICE-2, NICE2, S100A15, S100A7L1, S100A7f, protein S100-A7A, S100 calcium-binding protein A15, S100 calcium-binding protein A7-like 1, koebnerisin
Species: human
Products:     S100A7A

Top Publications

  1. Madsen P, Rasmussen H, Leffers H, Honore B, Dejgaard K, Olsen E, et al. Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin. J Invest Dermatol. 1991;97:701-12 pubmed
    ..Granulocyte extracts contained this protein suggesting that its overexpression by psoriatic keratinocytes may be linked to the inflammatory stimuli. ..
  2. Wolf R, Mirmohammadsadegh A, Walz M, Lysa B, Tartler U, Remus R, et al. Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family. FASEB J. 2003;17:1969-71 pubmed
    ..By sequence comparison, we have mapped the novel gene, named S100A15, to the S100 gene cluster within the epidermal differentiation complex (chromosome 1q21)...
  3. Wolf R, Howard O, Dong H, Voscopoulos C, Boeshans K, Winston J, et al. Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. J Immunol. 2008;181:1499-506 pubmed
    ..The identified S100A7 interaction with RAGE may provide a novel therapeutic target for inflammation. ..
  4. Britze A, Birkler R, Gregersen N, Ovesen T, Palmfeldt J. Large-scale proteomics differentiates cholesteatoma from surrounding tissues and identifies novel proteins related to the pathogenesis. PLoS ONE. 2014;9:e104103 pubmed publisher
    ..Cholesteatoma contained high levels of pro-inflammatory S100 proteins, such as S100A7A and S100A7...
  5. Bundela S, Sharma A, Bisen P. Potential therapeutic targets for oral cancer: ADM, TP53, EGFR, LYN, CTLA4, SKIL, CTGF, CD70. PLoS ONE. 2014;9:e102610 pubmed publisher
    ..metalloproteinases (MMP-1/3/10/13), chemokine (C-X-C motif) ligands (IL8, CXCL-10/-11), PTHLH, SERPINE1, NELL2, S100A7A, MAL, CRNN, TGM3, CLCA4, keratins (KRT-3/4/13/76/78), SERPINB11 and serine peptidase inhibitors (SPINK-5/7)...
  6. Wolf R, Ruzicka T, Yuspa S. Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function. Amino Acids. 2011;41:789-96 pubmed publisher
    S100A7 (psoriasin) and S100A15 (koebnerisin) were first identified in inflamed psoriatic skin...
  7. Bai Y, Li L, Li J, Lu X. Prognostic values of S100 family members in ovarian cancer patients. BMC Cancer. 2018;18:1256 pubmed publisher
    ..It was found that high expression of S100A2 (HR = 1.18, 95%CI: 1.04-1.34, P = 0.012), S100A7A (HR = 1.3, 95%CI: 1.04-1.63, P = 0.02),S100A10 (HR = 1.2, 95%CI: 1.05-1.38, P = 0...
  8. Wang C, Luo J, Rong J, He S, Zhang L, Zheng F. Distinct prognostic roles of S100 mRNA expression in gastric cancer. Pathol Res Pract. 2019;215:127-136 pubmed publisher
    ..Increased expression of S100A3, S100A5, S100A7, S100A7A, S100A11, S100A13, S100Z and S100 G were found to be strongly associated with worse survival, while S100A8, ..
  9. Águeda Pinto A, Esteves P. The evolution of S100A7 in primates: a model of concerted and birth-and-death evolution. Immunogenetics. 2019;71:25-33 pubmed publisher
    ..In humans, there are five S100A7 genes located in tandem-S100A7A, S100A7P1, S100AL2, S100A7, and S100AP2...

More Information


  1. Gauglitz G, Bureik D, Zwicker S, Ruzicka T, Wolf R. The antimicrobial peptides psoriasin (S100A7) and koebnerisin (S100A15) suppress extracellular matrix production and proliferation of human fibroblasts. Skin Pharmacol Physiol. 2015;28:115-23 pubmed publisher
    ..Psoriasin (S100A7) and koebnerisin (S100A15) are released by keratinocytes during physiological wound healing...
  2. Keermann M, Kõks S, Reimann E, Prans E, Abram K, Kingo K. Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RN. BMC Genomics. 2015;16:322 pubmed publisher
    ..In LP skin S100A12, S100A7A, LCE3E, DEFB4A, IL19 were found up regulated...
  3. Wolf R, Voscopoulos C, Winston J, Dharamsi A, Goldsmith P, Gunsior M, et al. Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer. Cancer Lett. 2009;277:101-7 pubmed publisher
    ..Further, hS100A7 and S100A15 transcripts are elevated in ER/PR negative breast cancers, but hS100A15 protein is detected in all cancer ..
  4. de Castro A, Minty F, Hattinger E, Wolf R, Parkinson E. The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators. Longev Healthspan. 2014;3:8 pubmed publisher
    ..We show here that S100A7 and the closely related S100A15 (koebnerisin) are not induced by repairable or irreparable DSBs, ruling out the hypotheses that these genes are induced ..
  5. Wolf R, Lewerenz V, Büchau A, Walz M, Ruzicka T. Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. Exp Dermatol. 2007;16:685-91 pubmed
    ..human calcium-binding protein (hS100A15) was first identified in inflamed hyperplastic psoriatic skin, where the S100A15 gene is transcribed into two mRNA splice variants, hS100A15-S and hS100A15-L...
  6. Marenholz I, Zirra M, Fischer D, Backendorf C, Ziegler A, Mischke D. Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. Genome Res. 2001;11:341-55 pubmed
    ..Moreover, the extended integrated map of the EDC, including the polymorphic sequence tag site (STS) markers D1S1664, D1S2346, and D1S305, will serve as a valuable tool for linkage analyses. ..
  7. Büchau A, Hassan M, Kukova G, Lewerenz V, Kellermann S, Wurthner J, et al. S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4. J Invest Dermatol. 2007;127:2596-604 pubmed
    ..We found that E. coli significantly induced human S100A7 and S100A15 transcript abundance and IL-8 release in cultured primary human keratinocytes...
  8. Kulski J, Lim C, Dunn D, Bellgard M. Genomic and phylogenetic analysis of the S100A7 (Psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21. J Mol Evol. 2003;56:397-406 pubmed
    ..We used PCR to amplify an indel within intron 1 of the S100A7a and S100A7c genes that gave the same two expected product sizes using 40 human DNA samples and 1 chimpanzee ..
  9. Hirai M, Graham J, Mattson K, Kelsey A, Mukherji S, Cronin A. Exploring Determinants of Handwashing with Soap in Indonesia: A Quantitative Analysis. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..This study concludes that handwashing with soap may be more effectively promoted through the use of non-health messages. ..
  10. Gao W, Li J, Chen S, Chu C, Chan J, Wong T. Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma. J Exp Clin Cancer Res. 2016;35:92 pubmed publisher
    ..Microarray experiment showed that S100A family members (S100A7, S100A7A, S100A8, S100A9 & S100A12) might be the downstream targets of BEX4 in OSCC...
  11. Moon H, Kim N, Jeong S, Lee M, Moon H, Kim J, et al. The Clinical Significance and Molecular Features of the Spatial Tumor Shapes in Breast Cancers. PLoS ONE. 2015;10:e0143811 pubmed publisher
    ..Network analysis and analysis of TCGA gene expression data suggest that MMP13 is regulated by ERBB2 and S100A7A. The present study validates the usefulness of the current tumor size method in determining tumor stages...
  12. Batycka Baran A, Hattinger E, Zwicker S, Summer B, Zack Howard O, Thomas P, et al. Leukocyte-derived koebnerisin (S100A15) and psoriasin (S100A7) are systemic mediators of inflammation in psoriasis. J Dermatol Sci. 2015;79:214-21 pubmed publisher
    Psoriasis is a systemic immune-mediated chronic inflammatory disease. In the skin, the antimicrobial proteins koebnerisin (S100A15) and psoriasin (S100A7) are overexpressed in the epidermis of psoriatic lesions and mediate inflammation ..
  13. Boeshans K, Wolf R, Voscopoulos C, Gillette W, Esposito D, Mueser T, et al. Purification, crystallization and preliminary X-ray diffraction of human S100A15. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006;62:467-70 pubmed
    Human S100A15 is a novel member of the S100 family of EF-hand calcium-binding proteins and was recently identified in psoriasis, where it is significantly upregulated in lesional skin...
  14. Marenholz I, Lovering R, Heizmann C. An update of the S100 nomenclature. Biochim Biophys Acta. 2006;1763:1282-3 pubmed
    ..Here we present the official and updated nomenclature of this protein family, approved by the HGNC (HUGO gene nomenclature committee) and ECS (European Calcium Society). ..
  15. Murray J, Tonkin M, Whiting A, Peng F, Farnell B, Cullen J, et al. Structural characterization of S100A15 reveals a novel zinc coordination site among S100 proteins and altered surface chemistry with functional implications for receptor binding. BMC Struct Biol. 2012;12:16 pubmed publisher
    ..the majority of human S100 proteins share 25-65% sequence similarity, S100A7 and its recently identified paralog, S100A15, display 93% sequence identity...
  16. Wolf R, Mascia F, Dharamsi A, Howard O, Cataisson C, Bliskovski V, et al. Gene from a psoriasis susceptibility locus primes the skin for inflammation. Sci Transl Med. 2010;2:61ra90 pubmed publisher
    ..psoriatic skin constitutively expresses elevated concentrations of S100A7 (psoriasin) and S100A15 (koebnerisin) in the epidermis...
  17. Mohammad H, Boardman J, Howell L, Mills R, Emsley H. Urgent referral for suspected CNS cancer: which clinical features are associated with a positive predictive value of 3 % or more?. BMC Neurol. 2016;16:152 pubmed publisher
    ..A 12-month retrospective evaluation of 393 patients referred under previous 2005 NICE 2-week rule criteria was conducted...
  18. Schmitt L, Amann P, Marquardt Y, Heise R, Czaja K, Gerber P, et al. Molecular effects of fractional ablative erbium:YAG laser treatment with multiple stacked pulses on standardized human three-dimensional organotypic skin models. Lasers Med Sci. 2017;32:805-814 pubmed publisher
    ..markers, such as keratin-associated protein 4, filaggrin, filaggrin 2, and loricrin, and antimicrobial peptides (S100A7A, S100A9, and S100A12) as well as CASP14, DSG2, IL18, and IL36? was reduced...
  19. Chen Y, Lin M, Hsiao C, Zheng Y, Chen K, Sung M, et al. Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma. Oncotarget. 2017;8:45710-45724 pubmed publisher
    This study aims to determine the functional role of S100A15 and its promoter DNA methylation patterns in lung cancer progression...