S100A7

Summary

Gene Symbol: S100A7
Description: S100 calcium binding protein A7
Alias: PSOR1, S100A7c, protein S100-A7, psoriasin 1
Species: human
Products:     S100A7

Top Publications

  1. Petersson S, Shubbar E, Yhr M, Kovacs A, Enerback C. Loss of ICAM-1 signaling induces psoriasin (S100A7) and MUC1 in mammary epithelial cells. Breast Cancer Res Treat. 2011;125:13-25 pubmed publisher
    Psoriasin (S100A7), a member of the S100 gene family, is highly expressed in high-grade comedo ductal carcinoma in situ (DCIS), with a higher risk of local recurrence...
  2. Morgan M, Jazayeri M, Ramsay A, Thomas G, Boulanger M, Hart I, et al. Psoriasin (S100A7) associates with integrin ?6 subunit and is required for ?v?6-dependent carcinoma cell invasion. Oncogene. 2011;30:1422-35 pubmed publisher
    ..approach to identify novel binding partners for the ?6 subunit cytoplasmic tail and report that psoriasin (Psor) (S100A7) bound preferentially to the recombinant ?6 cytoplasmic domain, though not in the absence of the unique C-terminal ..
  3. Lee K, Eckert R. S100A7 (Psoriasin)--mechanism of antibacterial action in wounds. J Invest Dermatol. 2007;127:945-57 pubmed
    b>S100A7, also called psoriasin, is a member of the S100 multigene family that is encoded in the epidermal differentiation complex on chromosome 1q21...
  4. Zhang H, Wang Y, Chen Y, Sun S, Li N, Lv D, et al. Identification and validation of S100A7 associated with lung squamous cell carcinoma metastasis to brain. Lung Cancer. 2007;57:37-45 pubmed
    ..b>S100A7 and 14-3-3sigma, two of candidate proteins significantly upregulated and downregulated in H226Br cell, were ..
  5. Emberley E, Niu Y, Leygue E, Tomes L, Gietz R, Murphy L, et al. Psoriasin interacts with Jab1 and influences breast cancer progression. Cancer Res. 2003;63:1954-61 pubmed
    Psoriasin (S100A7) is expressed at low levels in normal breast epithelial cells but is highly expressed in preinvasive ductal carcinoma in situ...
  6. Paruchuri V, Prasad A, McHugh K, Bhat H, Polyak K, Ganju R. S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation. PLoS ONE. 2008;3:e1741 pubmed publisher
    b>S100A7 is a small calcium binding protein, which has been shown to be differentially expressed in psoriatic skin lesions, as well as in squamous cell tumors of the skin, lung and breast...
  7. Bryborn M, Hallden C, Sall T, Adner M, Cardell L. Comprehensive evaluation of genetic variation in S100A7 suggests an association with the occurrence of allergic rhinitis. Respir Res. 2008;9:29 pubmed publisher
    b>S100A7 is a calcium-binding protein with chemotactic and antimicrobial properties...
  8. Wolf R, Howard O, Dong H, Voscopoulos C, Boeshans K, Winston J, et al. Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. J Immunol. 2008;181:1499-506 pubmed
    Human S100A7 (psoriasin) is overexpressed in inflammatory diseases. The recently discovered, co-evolved hS100A15 is almost identical in sequence and up-regulated with hS100A7 during cutaneous inflammation...
  9. al Haddad S, Zhang Z, Leygue E, Snell L, Huang A, Niu Y, et al. Psoriasin (S100A7) expression and invasive breast cancer. Am J Pathol. 1999;155:2057-66 pubmed
    Alteration of psoriasin (S100A7) expression has previously been identified in association with the transition from preinvasive to invasive breast cancer...
  10. Bryborn M, Mansson A, Cardell L, Adner M. Differentiated S100A7 expression in infected tonsils and tonsils from allergic individuals. FEMS Immunol Med Microbiol. 2008;53:413-20 pubmed publisher
    ..b>S100A7 is a protein with antimicrobial and chemotactic properties...

Detail Information

Publications74

  1. Petersson S, Shubbar E, Yhr M, Kovacs A, Enerback C. Loss of ICAM-1 signaling induces psoriasin (S100A7) and MUC1 in mammary epithelial cells. Breast Cancer Res Treat. 2011;125:13-25 pubmed publisher
    Psoriasin (S100A7), a member of the S100 gene family, is highly expressed in high-grade comedo ductal carcinoma in situ (DCIS), with a higher risk of local recurrence...
  2. Morgan M, Jazayeri M, Ramsay A, Thomas G, Boulanger M, Hart I, et al. Psoriasin (S100A7) associates with integrin ?6 subunit and is required for ?v?6-dependent carcinoma cell invasion. Oncogene. 2011;30:1422-35 pubmed publisher
    ..approach to identify novel binding partners for the ?6 subunit cytoplasmic tail and report that psoriasin (Psor) (S100A7) bound preferentially to the recombinant ?6 cytoplasmic domain, though not in the absence of the unique C-terminal ..
  3. Lee K, Eckert R. S100A7 (Psoriasin)--mechanism of antibacterial action in wounds. J Invest Dermatol. 2007;127:945-57 pubmed
    b>S100A7, also called psoriasin, is a member of the S100 multigene family that is encoded in the epidermal differentiation complex on chromosome 1q21...
  4. Zhang H, Wang Y, Chen Y, Sun S, Li N, Lv D, et al. Identification and validation of S100A7 associated with lung squamous cell carcinoma metastasis to brain. Lung Cancer. 2007;57:37-45 pubmed
    ..b>S100A7 and 14-3-3sigma, two of candidate proteins significantly upregulated and downregulated in H226Br cell, were ..
  5. Emberley E, Niu Y, Leygue E, Tomes L, Gietz R, Murphy L, et al. Psoriasin interacts with Jab1 and influences breast cancer progression. Cancer Res. 2003;63:1954-61 pubmed
    Psoriasin (S100A7) is expressed at low levels in normal breast epithelial cells but is highly expressed in preinvasive ductal carcinoma in situ...
  6. Paruchuri V, Prasad A, McHugh K, Bhat H, Polyak K, Ganju R. S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation. PLoS ONE. 2008;3:e1741 pubmed publisher
    b>S100A7 is a small calcium binding protein, which has been shown to be differentially expressed in psoriatic skin lesions, as well as in squamous cell tumors of the skin, lung and breast...
  7. Bryborn M, Hallden C, Sall T, Adner M, Cardell L. Comprehensive evaluation of genetic variation in S100A7 suggests an association with the occurrence of allergic rhinitis. Respir Res. 2008;9:29 pubmed publisher
    b>S100A7 is a calcium-binding protein with chemotactic and antimicrobial properties...
  8. Wolf R, Howard O, Dong H, Voscopoulos C, Boeshans K, Winston J, et al. Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. J Immunol. 2008;181:1499-506 pubmed
    Human S100A7 (psoriasin) is overexpressed in inflammatory diseases. The recently discovered, co-evolved hS100A15 is almost identical in sequence and up-regulated with hS100A7 during cutaneous inflammation...
  9. al Haddad S, Zhang Z, Leygue E, Snell L, Huang A, Niu Y, et al. Psoriasin (S100A7) expression and invasive breast cancer. Am J Pathol. 1999;155:2057-66 pubmed
    Alteration of psoriasin (S100A7) expression has previously been identified in association with the transition from preinvasive to invasive breast cancer...
  10. Bryborn M, Mansson A, Cardell L, Adner M. Differentiated S100A7 expression in infected tonsils and tonsils from allergic individuals. FEMS Immunol Med Microbiol. 2008;53:413-20 pubmed publisher
    ..b>S100A7 is a protein with antimicrobial and chemotactic properties...
  11. Krop I, März A, Carlsson H, Li X, Bloushtain Qimron N, Hu M, et al. A putative role for psoriasin in breast tumor progression. Cancer Res. 2005;65:11326-34 pubmed
    Psoriasin (S100A7) was identifi;ed as a gene highly expressed in psoriatic keratinocytes and highly and more frequently expressed in ductal carcinoma in situ (DCIS) than in invasive breast carcinomas (IBC), suggesting a potential role in ..
  12. Emberley E, Niu Y, Curtis L, Troup S, Mandal S, Myers J, et al. The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer. Cancer Res. 2005;65:5696-702 pubmed
    b>S100A7 is among the most highly expressed genes in preinvasive breast cancer, is a marker of poor survival when expressed in invasive disease, and promotes breast tumor progression in experimental models...
  13. Webb M, Emberley E, Lizardo M, Alowami S, Qing G, Alfia ar A, et al. Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis. BMC Cancer. 2005;5:17 pubmed
    The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of the murine psoriasin gene...
  14. Jiang W, Watkins G, Douglas Jones A, Mansel R. Psoriasin is aberrantly expressed in human breast cancer and is related to clinical outcomes. Int J Oncol. 2004;25:81-5 pubmed
    Psoriasin (S100A7) is a member of the S100 gene family that is involved in psoriasis, which can be induced in cultured squamous epithelial cells...
  15. Kulski J, Lim C, Dunn D, Bellgard M. Genomic and phylogenetic analysis of the S100A7 (Psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21. J Mol Evol. 2003;56:397-406 pubmed
    ..We used PCR to amplify an indel within intron 1 of the S100A7a and S100A7c genes that gave the same two expected product sizes using 40 human DNA samples and 1 chimpanzee sample, therefore ..
  16. Gläser R, Meyer Hoffert U, Harder J, Cordes J, Wittersheim M, Kobliakova J, et al. The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption. J Invest Dermatol. 2009;129:641-9 pubmed publisher
    ..coli. This indicates that the antimicrobial response in AD is not generally impaired, but greatly differs according to the type of AMP produced by the skin. ..
  17. Watson P, Leygue E, Murphy L. Psoriasin (S100A7). Int J Biochem Cell Biol. 1998;30:567-71 pubmed
    Psoriasin (S100A7) is a relatively new member of the S100 gene family that is located within the S100 gene cluster on chromosome 1q21 and shares the typical calcium binding domains that define this family of proteins...
  18. West N, Watson P. S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer. Oncogene. 2010;29:2083-92 pubmed publisher
    b>S100A7 promotes aggressive features in breast cancer, although regulation of its expression is poorly understood...
  19. Tieu D, Peters A, Carter R, Carter R, Suh L, Conley D, et al. Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis. J Allergy Clin Immunol. 2010;125:667-75 pubmed publisher
    Decreased epithelial expression of mRNA for S100A7 (psoriasin) and S100A8/A9 (calprotectin) has been reported in patients with chronic rhinosinusitis (CRS).
  20. Broome A, Ryan D, Eckert R. S100 protein subcellular localization during epidermal differentiation and psoriasis. J Histochem Cytochem. 2003;51:675-85 pubmed
    ..Our present studies compare the level of expression, and cellular localization of S100A7, S100A8, S100A9, S100A10, and S100A11 in normal and psoriatic epidermis...
  21. Ruse M, Broome A, Eckert R. S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes. J Invest Dermatol. 2003;121:132-41 pubmed
    ..Identifying S100 intracellular distribution, site of action, and protein targets are important goals. S100A7 (psoriasin) is an important member of this family that is markedly overexpressed in psoriatic keratinocytes; ..
  22. Wolf R, Mirmohammadsadegh A, Walz M, Lysa B, Tartler U, Remus R, et al. Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family. FASEB J. 2003;17:1969-71 pubmed
    ..sequence revealed a protein of 101 amino acids containing two potential EF-hand motifs with high homology to the S100A7. Northern blot hybridization and semiquantitative RT-PCR analysis confirmed the S100A15 overexpression in ..
  23. Emberley E, Alowami S, Snell L, Murphy L, Watson P. S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast. Breast Cancer Res. 2004;6:R308-15 pubmed
    The S100A7 (psoriasin) gene is highly expressed in ductal carcinoma in situ (DCIS) of the breast and can be downregulated in invasive carcinoma...
  24. Richer S, Truong Tran A, Conley D, Carter R, Vermylen D, Grammer L, et al. Epithelial genes in chronic rhinosinusitis with and without nasal polyps. Am J Rhinol. 2008;22:228-34 pubmed publisher
    ..Samples were analyzed for S100A7, S100A8, S100A9, SLC9A3R1, G-protein-coupled receptor for asthma, and serine protease inhibitor kazal type 5 (..
  25. Tripathi S, Matta A, Kaur J, Grigull J, Chauhan S, Thakar A, et al. Nuclear S100A7 is associated with poor prognosis in head and neck cancer. PLoS ONE. 2010;5:e11939 pubmed publisher
    ..labeling and liquid chromatography-mass spectrometry, led to the identification of a panel of biomarkers including S100A7. In the multi-step process of head and neck tumorigenesis, the presence of dysplastic areas in the epithelium is ..
  26. Schafer B, Wicki R, Engelkamp D, Mattei M, Heizmann C. Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Genomics. 1995;25:638-43 pubmed
    ..The new nomenclature should facilitate and further the understanding of this protein family and be easily expandable to other species. ..
  27. Baldini C, Giusti L, Bazzichi L, Ciregia F, Giannaccini G, Giacomelli C, et al. Association of psoriasin (S100A7) with clinical manifestations of systemic sclerosis: is its presence in whole saliva a potential predictor of pulmonary involvement?. J Rheumatol. 2008;35:1820-4 pubmed
    To evaluate psoriasin (S100A7) expression in whole saliva (WS) of patients with diffuse systemic sclerosis (dSSc) and limited SSc (lSSc), and to correlate its presence with the different clinical manifestations of the disease...
  28. Carlsson H, Yhr M, Petersson S, Collins N, Polyak K, Enerback C. Psoriasin (S100A7) and calgranulin-B (S100A9) induction is dependent on reactive oxygen species and is downregulated by Bcl-2 and antioxidants. Cancer Biol Ther. 2005;4:998-1005 pubmed
  29. Bryborn M, Adner M, Cardell L. Psoriasin, one of several new proteins identified in nasal lavage fluid from allergic and non-allergic individuals using 2-dimensional gel electrophoresis and mass spectrometry. Respir Res. 2005;6:118 pubmed
    ..DNA microarrays have recently made it possible to compare mRNA profiles of lavage fluids from healthy and diseased patients, whereas information on the protein level is still lacking...
  30. Hagens G, Roulin K, Hotz R, Saurat J, Hellman U, Siegenthaler G. Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales. Mol Cell Biochem. 1999;192:123-8 pubmed
    The overexpression of E-FABP and S100A7 in lesional psoriatic skin suggests a possible link with this hyperproliferative skin disease...
  31. Moubayed N, Weichenthal M, Harder J, Wandel E, Sticherling M, Gläser R. Psoriasin (S100A7) is significantly up-regulated in human epithelial skin tumours. J Cancer Res Clin Oncol. 2007;133:253-61 pubmed
    Psoriasin (S100A7) has originally been described to be expressed by psoriatic keratinocytes possibly as a result of altered differentiation and inflammation...
  32. Martinsson H, Yhr M, Enerback C. Expression patterns of S100A7 (psoriasin) and S100A9 (calgranulin-B) in keratinocyte differentiation. Exp Dermatol. 2005;14:161-8 pubmed
    S100 proteins are involved in many biological processes. S100A7 and S100A9 have been shown to be markedly upregulated both in ductal carcinoma in situ of the breast and in psoriasis...
  33. Gläser R, Harder J, Lange H, Bartels J, Christophers E, Schroder J. Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. Nat Immunol. 2005;6:57-64 pubmed
    ..Zn(2+)-saturated psoriasin showed diminished antimicrobial activity, suggesting that Zn(2+) sequestration could be a possible antimicrobial mechanism. Thus, psoriasin may be key to the resistance of skin against E. coli. ..
  34. Andresen E, Lange C, Strodthoff D, Goldmann T, Fischer N, Sahly H, et al. S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection. BMC Pulm Med. 2011;11:10 pubmed publisher
    ..b>S100A7/psoriasin, a recently described AMP, is an essential component of the human epithelia against invading pathogens ..
  35. Petersson S, Bylander A, Yhr M, Enerback C. S100A7 (Psoriasin), highly expressed in ductal carcinoma in situ (DCIS), is regulated by IFN-gamma in mammary epithelial cells. BMC Cancer. 2007;7:205 pubmed
    The aim of the present work was to explore signal transduction pathways used in the regulation of S100A7 (psoriasin). Members of the S100 gene family participate in many important cellular functions...
  36. Meyer Hoffert U, Zimmermann A, Czapp M, Bartels J, Koblyakova Y, Gläser R, et al. Flagellin delivery by Pseudomonas aeruginosa rhamnolipids induces the antimicrobial protein psoriasin in human skin. PLoS ONE. 2011;6:e16433 pubmed publisher
    ..Hereby, human skin might control the microflora to prevent colonization of unwanted microbes in the earliest steps before potential pathogens can develop strategies to subvert the immune response. ..
  37. Celis J, Rasmussen H, Vorum H, Madsen P, Honore B, Wolf H, et al. Bladder squamous cell carcinomas express psoriasin and externalize it to the urine. J Urol. 1996;155:2105-12 pubmed
    ..The results point towards psoriasin, alone or as part of a biomarker profile, as a potential marker for the noninvasive follow-up of patients with SCC. ..
  38. Leon R, Murray J, Cragg G, Farnell B, West N, Pace T, et al. Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways. Biochemistry. 2009;48:10591-600 pubmed publisher
    b>S100A7 (psoriasin) is a member of the S100 family of signaling proteins. It is implicated in and considered a therapeutic target for inflammation and cancer, yet no small molecule ligands for S100A7 have been identified...
  39. Semprini S, Capon F, Bovolenta S, Bruscia E, Pizzuti A, Fabrizi G, et al. Genomic structure, promoter characterisation and mutational analysis of the S100A7 gene: exclusion of a candidate for familial psoriasis susceptibility. Hum Genet. 1999;104:130-4 pubmed
    ..In order to analyse S100A7 as a candidate for PS susceptibility, we have determined its genomic structure regarding exon-intron boundaries ..
  40. Madsen P, Rasmussen H, Leffers H, Honore B, Dejgaard K, Olsen E, et al. Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin. J Invest Dermatol. 1991;97:701-12 pubmed
    ..Granulocyte extracts contained this protein suggesting that its overexpression by psoriatic keratinocytes may be linked to the inflammatory stimuli. ..
  41. Hoffmann H, Olsen E, Etzerodt M, Madsen P, Thøgersen H, Kruse T, et al. Psoriasin binds calcium and is upregulated by calcium to levels that resemble those observed in normal skin. J Invest Dermatol. 1994;103:370-5 pubmed
    ..56) to levels that resemble those observed in unfractionated keratinocyte populations obtained from normal skin. ..
  42. Schafer B, Heizmann C. The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem Sci. 1996;21:134-40 pubmed
    ..Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging. ..
  43. Ruse M, Lambert A, Robinson N, Ryan D, Shon K, Eckert R. S100A7, S100A10, and S100A11 are transglutaminase substrates. Biochemistry. 2001;40:3167-73 pubmed
    ..We suggest that transglutaminase-dependent modification is a general mechanism designed to regulate S100 protein function. ..
  44. Enerback C, Porter D, Seth P, Sgroi D, Gaudet J, Weremowicz S, et al. Psoriasin expression in mammary epithelial cells in vitro and in vivo. Cancer Res. 2002;62:43-7 pubmed
    ..All of these conditions are characteristic of high-grade DCIS and psoriatic skin lesions; therefore, the same mechanisms may be responsible for increased expression of psoriasin in vitro and in vivo. ..
  45. Brodersen D, Etzerodt M, Madsen P, Celis J, Thøgersen H, Nyborg J, et al. EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing. Structure. 1998;6:477-89 pubmed
    ..Psoriasin (S100A7) is an 11...
  46. Abtin A, Eckhart L, Mildner M, Gruber F, Schroder J, Tschachler E. Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli. FASEB J. 2008;22:2168-76 pubmed publisher
    ..It has recently been shown that the culture supernatant of Escherichia coli induces the expression of S100A7c (psoriasin) in KCs and that S100A7c efficiently kills E. coli...
  47. Zhou G, Xie T, Zhao M, Jasser S, Younes M, Sano D, et al. Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity. Oncogene. 2008;27:3527-38 pubmed publisher
    Overexpression of S100A7 (psoriasin), a small calcium-binding protein, has been associated with the development of psoriasis and carcinomas in different types of epithelia, but its precise functions are still unknown...
  48. Nasser M, Qamri Z, Deol Y, Ravi J, Powell C, Trikha P, et al. S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways. Cancer Res. 2012;72:604-15 pubmed publisher
    b>S100A7/psoriasin, a member of the epidermal differentiation complex, is widely overexpressed in invasive estrogen receptor (ER)?-negative breast cancers...
  49. Hardas B, Zhao X, Zhang J, Longqing X, Stoll S, Elder J. Assignment of psoriasin to human chromosomal band 1q21: coordinate overexpression of clustered genes in psoriasis. J Invest Dermatol. 1996;106:753-8 pubmed
    ..Psoriasin and several other tightly linked 1q21 genes were markedly overexpressed in psoriatic lesions, suggesting a role for these clustered genes in the regulation of epidermal proliferation. ..
  50. Emberley E, Gietz R, Campbell J, Hayglass K, Murphy L, Watson P. RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer. BMC Cancer. 2002;2:28 pubmed
    ..0001) within the tumor. These findings support the hypothesis that psoriasin may interact with RanBPM and this may influence both epithelial and stromal cells and thus contribute to breast tumor progression. ..
  51. Ekman A, Vegfors J, Eding C, Enerback C. Overexpression of Psoriasin (S100A7) Contributes to Dysregulated Differentiation in Psoriasis. Acta Derm Venereol. 2017;97:441-448 pubmed publisher
    ..These findings suggest that psoriasin contributes to the dysregulated differentiation process in the psoriasis epidermis. ..
  52. Michalek M, Gelhaus C, Hecht O, Podschun R, Schroder J, Leippe M, et al. The human antimicrobial protein psoriasin acts by permeabilization of bacterial membranes. Dev Comp Immunol. 2009;33:740-6 pubmed publisher
    Psoriasin, a member of the S100 family of calcium-binding proteins (S100A7) is highly upregulated in the skin of psoriasis patients...
  53. Gordon K, Kochkodan J, Blatt H, Lin S, Kaplan N, Johnston A, et al. Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis. J Invest Dermatol. 2013;133:712-722 pubmed publisher
    ..of growth factors and cytokines elevated in psoriasis increased EphA2 mRNA and protein expression while inducing S100A7 and disrupting differentiation...
  54. Ismail M, El Boghdady N, Shabayek M, Awida H, Abozeed H. Evaluation and screening of mRNA S100A genes as serological biomarkers in different stages of bladder cancer in Egypt. Tumour Biol. 2016;37:4621-31 pubmed publisher
    ..Both S100A4 and S100A6 can be used to differentiate between different stages of bladder cancer. S100A7 can be used for the diagnosis of squamous cell carcinoma...
  55. Deol Y, Nasser M, Yu L, Zou X, Ganju R. Tumor-suppressive effects of psoriasin (S100A7) are mediated through the ?-catenin/T cell factor 4 protein pathway in estrogen receptor-positive breast cancer cells. J Biol Chem. 2011;286:44845-54 pubmed publisher
    Psoriasin (S100A7) is expressed in several epithelial malignancies including breast cancer...
  56. Padilla L, Dakhel S, Adan J, Masa M, Martinez J, Roque L, et al. S100A7: from mechanism to cancer therapy. Oncogene. 2017;: pubmed publisher
    ..Among these factors, S100A7 protein has gained interest in the last years...
  57. Kim K, Cho J, Song J, Woo J, Lee H, Jung H, et al. Psoriasin (S100A7), an antimicrobial peptide, is increased in human middle ear cholesteatoma. Acta Otolaryngol. 2009;129:1067-71 pubmed publisher
  58. Li Y, Kong F, Wang J, Hu E, Wang R, Liu J, et al. S100A7 induction is repressed by YAP via the Hippo pathway in A431 cells. Oncotarget. 2016;7:38133-38142 pubmed publisher
    ..Our previous study demonstrated that S100A7 was upregulated in several squamous cell carcinoma (SCC) specimens and was dramatically induced in SCC cells by ..
  59. Zhao H, Wilkie T, Deol Y, Sneh A, Ganju A, Basree M, et al. miR-29b defines the pro-/anti-proliferative effects of S100A7 in breast cancer. Mol Cancer. 2015;14:11 pubmed publisher
    b>S100A7 (Psoriasin) is an inflammatory protein known to be upregulated in breast cancer...
  60. Rohleder N, Wolff K, Heimüller S, Axt A, Kesting M, Koerdt S, et al. Influence of gender on epithelial host defence peptide gene expression under non-infected and infected conditions: A basic medical research study. J Craniomaxillofac Surg. 2018;46:128-134 pubmed publisher
    ..Expression levels of HDP human beta-defensin (hBD)-1, -2 and -3 and psoriasin (S100A7) were analysed, by using real-time polymerase chain reaction, in samples of epithelium from infected surgical ..
  61. Jeong S, Kim H, Jang Y, Ryu W, Lee H, Kim J, et al. Egr-1 is a key regulator of IL-17A-induced psoriasin upregulation in psoriasis. Exp Dermatol. 2014;23:890-5 pubmed publisher
    ..Through microarray analysis, we found out that psoriasin (S100A7) expression was increased in the Egr-1 overexpressed cells...
  62. Büchau A, Hassan M, Kukova G, Lewerenz V, Kellermann S, Wurthner J, et al. S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4. J Invest Dermatol. 2007;127:2596-604 pubmed
    ..We found that E. coli significantly induced human S100A7 and S100A15 transcript abundance and IL-8 release in cultured primary human keratinocytes...
  63. Winter J, Pantelis A, Allam J, Novak N, Reich R, Martini M, et al. High ?-defensin and S100A7 expression and missing DOC-1 down-regulation characterize irritation fibromas of the oral cavity and may counteract malignant transformation. J Craniofac Surg. 2011;22:100-4 pubmed publisher
    ..RNA was extracted according to standard protocols, and transcription levels of CCL20, DEFA 1/3, DEFA 4, S100A7, DOC-1, interleukin (IL) 1?, IL-6, IL-8, IL-10, tumor necrosis factor ?, Cox-2, matrix metalloproteinase 1 (MMP-1),..
  64. Vegfors J, Petersson S, Kovács A, Polyak K, Enerback C. The expression of Psoriasin (S100A7) and CD24 is linked and related to the differentiation of mammary epithelial cells. PLoS ONE. 2012;7:e53119 pubmed publisher
    Psoriasin (S100A7), a member of the S100 family of calcium-binding proteins, is highly expressed in high-grade ductal carcinoma in situ (DCIS) and in the benign hyperproliferative skin disorder psoriasis...
  65. Gauglitz G, Bureik D, Zwicker S, Ruzicka T, Wolf R. The antimicrobial peptides psoriasin (S100A7) and koebnerisin (S100A15) suppress extracellular matrix production and proliferation of human fibroblasts. Skin Pharmacol Physiol. 2015;28:115-23 pubmed publisher
    ..Psoriasin (S100A7) and koebnerisin (S100A15) are released by keratinocytes during physiological wound healing...
  66. Salama R, Al Shobaili H, Al Robaee A, Alzolibani A. Psoriasin: a novel marker linked obesity with psoriasis. Dis Markers. 2013;34:33-9 pubmed publisher
    ..Its sensitivity and specificity were 87%, 93%; respectively. To our knowledge, psoriasin is the first biomarker confirm the link between obesity and psoriasis. The risk of developing psoriasis is directly related to higher BMI. ..
  67. Cancemi P, Di Cara G, Albanese N, Costantini F, Marabeti M, Musso R, et al. Differential occurrence of S100A7 in breast cancer tissues: a proteomic-based investigation. Proteomics Clin Appl. 2012;6:364-73 pubmed publisher
    ..a large-scale proteomic screening of the occurrence, subcellular localization and relative quantification of the S100A7 protein among a group of 100 patients, clinically grouped for the diagnosis of infiltrating ductal carcinoma (IDC)...
  68. Erhart W, Alkasi O, Brunke G, Wegener F, Maass N, Arnold N, et al. Induction of human ?-defensins and psoriasin in vulvovaginal human papillomavirus-associated lesions. J Infect Dis. 2011;204:391-9 pubmed publisher
    ..Curiously, hBD-1 shows a significant induction whereas RNase7 does not, which suggests differing regulation of AMPs over the course of bacterial and viral infections. ..
  69. Giusti L, Sernissi F, Donadio E, Ciregia F, Giacomelli C, Giannaccini G, et al. Salivary psoriasin (S100A7) correlates with diffusion capacity of carbon monoxide in a large cohort of systemic sclerosis patients. J Transl Med. 2016;14:262 pubmed publisher
    ..In a previous work we suggested a correlation between levels of salivary psoriasin (S100A7) and pulmonary involvement in SSc patients...
  70. Kim H, Lee E, Lee M, Ahn S, Kim J, Liu J, et al. Phosphodiesterase 4B plays a role in benzophenone-3-induced phototoxicity in normal human keratinocytes. Toxicol Appl Pharmacol. 2018;338:174-181 pubmed publisher
    ..factors, such as prostaglandin endoperoxide synthase 2, tumor necrosis factor α, interleukin 8, and S100A7, and downregulated the level of cornified envelope associated proteins, which are important in the development of ..
  71. Gemmill R, Bemis L, Lee J, Sozen M, Baron A, Zeng C, et al. The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Oncogene. 2002;21:3507-16 pubmed
    ..Thus, VHL, TRC8, and JAB1 appear to be linked both physically and functionally and all three may participate in the development of kidney cancer. ..
  72. Sun W, Zheng Y, Lu Z, Cui Y, Tian Q, Xiao S, et al. Overexpression of S100A7 protects LPS-induced mitochondrial dysfunction and stimulates IL-6 and IL-8 in HaCaT cells. PLoS ONE. 2014;9:e92927 pubmed publisher
    b>S100A7 (or psoriasin) is distributed in the cytoplasm of keratinocytes of normal human epidermis, and it is overexpressed in many epidermal inflammatory diseases...