S100A2

Summary

Gene Symbol: S100A2
Description: S100 calcium binding protein A2
Alias: CAN19, S100L, protein S100-A2
Species: human
Products:     S100A2

Top Publications

  1. Zhang T, Woods T, Elder J. Differential responses of S100A2 to oxidative stress and increased intracellular calcium in normal, immortalized, and malignant human keratinocytes. J Invest Dermatol. 2002;119:1196-201 pubmed
    b>S100A2 is a calmodulin-like, p53-inducible, homodimeric protein that is readily oxidized in keratinocytes subjected to oxidative stress...
  2. Lapi E, Iovino A, Fontemaggi G, Soliera A, Iacovelli S, Sacchi A, et al. S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation. Oncogene. 2006;25:3628-37 pubmed
    ..Indeed, both p73- and p63-deficient mice exhibit severe developmental defects. Here, we show that S100A2 gene, whose transcript and protein are induced during keratinocyte differentiation of HaCaT cells, is a direct ..
  3. Naz S, Ranganathan P, Bodapati P, Shastry A, Mishra L, Kondaiah P. Regulation of S100A2 expression by TGF-?-induced MEK/ERK signalling and its role in cell migration/invasion. Biochem J. 2012;447:81-91 pubmed publisher
    b>S100A2, an EF hand calcium-binding protein, is a potential biomarker in several cancers and is also a TGF-? (transforming growth factor-?)-regulated gene in melanoma and lung cancer cells...
  4. Lee S, Tomasetto C, Swisshelm K, Keyomarsi K, Sager R. Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment. Proc Natl Acad Sci U S A. 1992;89:2504-8 pubmed
    A cDNA clone, designated CaN19 (originally called clone 19), isolated by subtractive hybridization, contains sequences that are preferentially expressed in normal mammary epithelial cells but not in breast tumor cells...
  5. Shimamoto S, Kubota Y, Tokumitsu H, Kobayashi R. S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. FEBS Lett. 2010;584:1119-25 pubmed publisher
    ..Using glutathione-S transferase pull-down assays and immunoprecipitation, we have demonstrated that S100A1 and S100A2 specifically interact with the TPR domains of FKBP52 and CyP40 in a Ca(2+)-dependent manner, and lead to ..
  6. Bulk E, Sargin B, Krug U, Hascher A, Jun Y, Knop M, et al. S100A2 induces metastasis in non-small cell lung cancer. Clin Cancer Res. 2009;15:22-9 pubmed publisher
    ..of all S100 proteins in early stage non-small cell lung cancer (NSCLC) patients as well as the pathogenetic of S100A2 in the development of metastasis in NSCLC...
  7. Wicki R, Franz C, Scholl F, Heizmann C, Schafer B. Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation. Cell Calcium. 1997;22:243-54 pubmed
    The calcium-binding protein S100A2 is expressed in normal breast tissue but downregulated during breast cancer progression. Hence it was previously identified as a candidate tumor suppressor gene...
  8. Kirschner R, Sänger K, Müller G, Engeland K. Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site. Nucleic Acids Res. 2008;36:2969-80 pubmed publisher
    b>S100A2 is generally found expressed in the epidermis and was recently shown to play a crucial role in the differentiation of keratinocytes. Also known as CaN19, S100A2 was identified as a potential tumor suppressor...
  9. Shimamoto S, Takata M, Tokuda M, Oohira F, Tokumitsu H, Kobayashi R. Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain. J Biol Chem. 2008;283:28246-58 pubmed publisher
    b>S100A2 and S100A6 interact with several target proteins in a Ca2+-regulated manner. However, the exact intracellular roles of the S100 proteins are unclear...
  10. Shimamoto S, Kubota Y, Yamaguchi F, Tokumitsu H, Kobayashi R. Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein). J Biol Chem. 2013;288:7158-68 pubmed publisher
    ..GST pulldown assays indicated that Ca(2+)/S100A2 and S100P bind to the TPR domain and lead to interference with the interactions of CHIP with Hsp70, Hsp90, HSF1, ..

Detail Information

Publications72

  1. Zhang T, Woods T, Elder J. Differential responses of S100A2 to oxidative stress and increased intracellular calcium in normal, immortalized, and malignant human keratinocytes. J Invest Dermatol. 2002;119:1196-201 pubmed
    b>S100A2 is a calmodulin-like, p53-inducible, homodimeric protein that is readily oxidized in keratinocytes subjected to oxidative stress...
  2. Lapi E, Iovino A, Fontemaggi G, Soliera A, Iacovelli S, Sacchi A, et al. S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation. Oncogene. 2006;25:3628-37 pubmed
    ..Indeed, both p73- and p63-deficient mice exhibit severe developmental defects. Here, we show that S100A2 gene, whose transcript and protein are induced during keratinocyte differentiation of HaCaT cells, is a direct ..
  3. Naz S, Ranganathan P, Bodapati P, Shastry A, Mishra L, Kondaiah P. Regulation of S100A2 expression by TGF-?-induced MEK/ERK signalling and its role in cell migration/invasion. Biochem J. 2012;447:81-91 pubmed publisher
    b>S100A2, an EF hand calcium-binding protein, is a potential biomarker in several cancers and is also a TGF-? (transforming growth factor-?)-regulated gene in melanoma and lung cancer cells...
  4. Lee S, Tomasetto C, Swisshelm K, Keyomarsi K, Sager R. Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment. Proc Natl Acad Sci U S A. 1992;89:2504-8 pubmed
    A cDNA clone, designated CaN19 (originally called clone 19), isolated by subtractive hybridization, contains sequences that are preferentially expressed in normal mammary epithelial cells but not in breast tumor cells...
  5. Shimamoto S, Kubota Y, Tokumitsu H, Kobayashi R. S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. FEBS Lett. 2010;584:1119-25 pubmed publisher
    ..Using glutathione-S transferase pull-down assays and immunoprecipitation, we have demonstrated that S100A1 and S100A2 specifically interact with the TPR domains of FKBP52 and CyP40 in a Ca(2+)-dependent manner, and lead to ..
  6. Bulk E, Sargin B, Krug U, Hascher A, Jun Y, Knop M, et al. S100A2 induces metastasis in non-small cell lung cancer. Clin Cancer Res. 2009;15:22-9 pubmed publisher
    ..of all S100 proteins in early stage non-small cell lung cancer (NSCLC) patients as well as the pathogenetic of S100A2 in the development of metastasis in NSCLC...
  7. Wicki R, Franz C, Scholl F, Heizmann C, Schafer B. Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation. Cell Calcium. 1997;22:243-54 pubmed
    The calcium-binding protein S100A2 is expressed in normal breast tissue but downregulated during breast cancer progression. Hence it was previously identified as a candidate tumor suppressor gene...
  8. Kirschner R, Sänger K, Müller G, Engeland K. Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site. Nucleic Acids Res. 2008;36:2969-80 pubmed publisher
    b>S100A2 is generally found expressed in the epidermis and was recently shown to play a crucial role in the differentiation of keratinocytes. Also known as CaN19, S100A2 was identified as a potential tumor suppressor...
  9. Shimamoto S, Takata M, Tokuda M, Oohira F, Tokumitsu H, Kobayashi R. Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain. J Biol Chem. 2008;283:28246-58 pubmed publisher
    b>S100A2 and S100A6 interact with several target proteins in a Ca2+-regulated manner. However, the exact intracellular roles of the S100 proteins are unclear...
  10. Shimamoto S, Kubota Y, Yamaguchi F, Tokumitsu H, Kobayashi R. Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein). J Biol Chem. 2013;288:7158-68 pubmed publisher
    ..GST pulldown assays indicated that Ca(2+)/S100A2 and S100P bind to the TPR domain and lead to interference with the interactions of CHIP with Hsp70, Hsp90, HSF1, ..
  11. Zhang X, Hunt J, Shin D, Chen Z. Down-regulation of S100A2 in lymph node metastases of head and neck cancer. Head Neck. 2007;29:236-43 pubmed
    Our cDNA microarray analysis of squamous cell carcinoma of the head and neck (SCCHN) previously identified that S100A2 was down-regulated in highly metastatic 686LN-M3s cell lines established through in vivo selection using a metastatic ..
  12. Mueller A, Schafer B, Ferrari S, Weibel M, Makek M, Höchli M, et al. The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity. J Biol Chem. 2005;280:29186-93 pubmed
    Head and neck squamous cell carcinoma express high levels of the EF-hand calcium-binding protein S100A2 in contrast to other tumorigenic tissues and cell lines where the expression of this protein is reduced...
  13. Hibi K, Fujitake S, Takase T, Kodera Y, Ito K, Akiyama S, et al. Identification of S100A2 as a target of the DeltaNp63 oncogenic pathway. Clin Cancer Res. 2003;9:4282-5 pubmed
    ..We found that S100A2 might be a target of the DeltaNp63 pathway...
  14. Deshpande R, Woods T, Fu J, Zhang T, Stoll S, Elder J. Biochemical characterization of S100A2 in human keratinocytes: subcellular localization, dimerization, and oxidative cross-linking. J Invest Dermatol. 2000;115:477-85 pubmed
    b>S100A2 is a calmodulin-like protein of unknown function, whose transcription is positively regulated in response to ErbB and p53 signaling...
  15. Mueller A, Bachi T, Höchli M, Schafer B, Heizmann C. Subcellular distribution of S100 proteins in tumor cells and their relocation in response to calcium activation. Histochem Cell Biol. 1999;111:453-9 pubmed
    ..The present work demonstrates a distinct intracellular localization of S100A6, S100A4, and S100A2 in two tumor cell lines derived from metastatic epithelial breast adenocarcinoma (MDA-MB231) and cervical ..
  16. Franz C, Durussel I, Cox J, Schafer B, Heizmann C. Binding of Ca2+ and Zn2+ to human nuclear S100A2 and mutant proteins. J Biol Chem. 1998;273:18826-34 pubmed
    The Ca2+-binding protein S100A2 is an unusual member of the S100 family, characterized by its nuclear localization and down-regulated expression in tumorigenic cells...
  17. Boni R, Burg G, Doguoglu A, Ilg E, Schafer B, Muller B, et al. Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions. Br J Dermatol. 1997;137:39-43 pubmed
    The purpose of this study was to evaluate the expression of the Ca(2+)-binding S100 proteins S100A1, S100A2, S100A3, S100A4, S100A6 and S100B in normal skin...
  18. Feng M, Ning W, Wang W, Lv Z, Liu X, Zhu Y, et al. Serum S100A12 as a prognostic biomarker of severe traumatic brain injury. Clin Chim Acta. 2018;480:84-91 pubmed publisher
    ..Serum S100A2 was independently associated with IMAEs and 30-day mortality and overall survival...
  19. Luo J, Zhu Y, Yang G, Gong L, Wang B, Liu H. Loss of Reprimo and S100A2 expression in human gastric adenocarcinoma. Diagn Cytopathol. 2011;39:752-7 pubmed publisher
    Reprimo and S100A2 are two newly identified candidate tumor-suppressor genes, which play an important role in the regulation of p53-dependent cell cycle...
  20. Chen C, Hsia C, Ho C, Liang C, Chen C, Huang K, et al. Hypoxia and hyperoxia differentially control proliferation of rat neural crest stem cells via distinct regulatory pathways of the HIF1?-CXCR4 and TP53-TPM1 proteins. Dev Dyn. 2017;246:162-185 pubmed publisher
    ..decreased cytoplasmic expression of TPM1 (tropomyosin-1), and increased nuclear-to-cytoplasmic translocation of S100A2. Incubation of rNCSCs with the antioxidant N-acetylcysteine (NAC) overcame the inhibitory effect of 80% oxygen on ..
  21. Ying J, Wang J, Ji H, Lin C, Pan R, Zhou L, et al. Transcriptome analysis of phycocyanin inhibitory effects on SKOV-3 cell proliferation. Gene. 2016;585:58-64 pubmed publisher
    ..qPCR results further showed that PTPN12, S100A2, RPL26, and LAMA3 increased while HNRNPA1P10 decreased in PC-treated cells...
  22. Goodwin Z, de Guzman Strong C. Recent Positive Selection in Genes of the Mammalian Epidermal Differentiation Complex Locus. Front Genet. 2016;7:227 pubmed publisher
    ..Significant non-synonymous substitutions were found in filaggrin, SPRR4, LELP1, and S100A2 genes across 14 mammals. By contrast, we identified recent positive selection in SPRR4 in primates...
  23. Imbalzano E, Mandraffino G, Casciaro M, Quartuccio S, Saitta A, Gangemi S. Pathophysiological mechanism and therapeutic role of S100 proteins in cardiac failure: a systematic review. Heart Fail Rev. 2016;21:463-73 pubmed publisher
    ..b>S100A2 seems to increase both contractile and relaxation performance in animal cardiomyocytes...
  24. Masuda T, Ishikawa T, Mogushi K, Okazaki S, Ishiguro M, Iida S, et al. Overexpression of the S100A2 protein as a prognostic marker for patients with stage II and III colorectal cancer. Int J Oncol. 2016;48:975-82 pubmed publisher
    ..Of these proteins, the S100 calcium-binding protein A2 (S100A2) has been observed in several human cancers...
  25. Pillay V, Isaacson C, Mothobi P, Hale M, Tomar L, Tyagi C, et al. Carcinogenic nitrosamines in traditional beer as the cause of oesophageal squamous cell carcinoma in black South Africans. S Afr Med J. 2015;105:656-8 pubmed
    ..beer samples, and molecular docking studies were employed to predict the affinity between N-nitrosamines and the S100A2 protein...
  26. Koch M, Fritz G. The structure of Ca2+-loaded S100A2 at 1.3-Å resolution. FEBS J. 2012;279:1799-810 pubmed publisher
    b>S100A2 is an EF-hand calcium ion (Ca(2+))-binding protein that activates the tumour suppressor p53...
  27. Wang T, Liang Y, Thakur A, Zhang S, Yang T, Chen T, et al. Diagnostic significance of S100A2 and S100A6 levels in sera of patients with non-small cell lung cancer. Tumour Biol. 2016;37:2299-304 pubmed publisher
    ..Recent studies have demonstrated a link involving S100 Calcium Binding Proteins (S100A2, S100A6) and non-small cell lung cancer (NSCLC), but the expediency of their serum levels in NSCLC has not been ..
  28. Bachet J, Marechal R, Demetter P, Bonnetain F, Cros J, Svrcek M, et al. S100A2 is a predictive biomarker of adjuvant therapy benefit in pancreatic adenocarcinoma. Eur J Cancer. 2013;49:2643-53 pubmed publisher
    Prognosis of patients with pancreatic adenocarcinoma (PAC) remains poor. S100A2 has been recently suggested as a negative prognostic biomarker in PAC...
  29. Naz S, Bashir M, Ranganathan P, Bodapati P, Santosh V, Kondaiah P. Protumorigenic actions of S100A2 involve regulation of PI3/Akt signaling and functional interaction with Smad3. Carcinogenesis. 2014;35:14-23 pubmed publisher
    ..Among several S100 members, altered expression of S100A2 is a potential diagnostic and prognostic marker in cancer. Several reports suggest a role for S100A2 in metastasis...
  30. Shimada A, Kano J, Ishiyama T, Okubo C, Iijima T, Morishita Y, et al. Establishment of an immortalized cell line from a precancerous lesion of lung adenocarcinoma, and genes highly expressed in the early stages of lung adenocarcinoma development. Cancer Sci. 2005;96:668-75 pubmed
    ..32%) of them encoded tumor-associated calcium signal transducer 2 (TACSTD2) and S100 calcium binding protein A2 (S100A2), respectively. The high transcription of TACSTD2 and S100A2 in PL16T was confirmed by in situ hybridization...
  31. Wasuworawong K, Roytrakul S, Paemanee A, Jindapornprasert K, Komyod W. Comparative Proteomic Analysis of Human Cholangiocarcinoma Cell Lines: S100A2 as a Potential Candidate Protein Inducer of Invasion. Dis Markers. 2015;2015:629367 pubmed publisher
    ..b>S100A2, a calcium-binding protein in S100 protein family, is upregulated in KKU-M213...
  32. Schafer B, Heizmann C. The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem Sci. 1996;21:134-40 pubmed
    ..Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging. ..
  33. Engelkamp D, Schafer B, Mattei M, Erne P, Heizmann C. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. Proc Natl Acad Sci U S A. 1993;90:6547-51 pubmed
  34. Sato Y, Harada K, Sasaki M, Nakanuma Y. Clinicopathological significance of S100 protein expression in cholangiocarcinoma. J Gastroenterol Hepatol. 2013;28:1422-9 pubmed publisher
    ..Immunohistochemical analysis was performed for the expression of S100A2, S100A4, S100A6, and S100P. Bile concentrations of S100P were measured using enzyme-linked immunosorbent assay...
  35. Tsai W, Lin Y, Tsai S, Shen W, Chao T, Lee S, et al. Lack of modulatory function of coding nucleotide polymorphism S100A2_185G>A in oral squamous cell carcinoma. Oral Dis. 2011;17:283-90 pubmed publisher
    b>S100A2, a Ca(2+) -binding protein with two EF-hands, is a tumor suppressor in oral cancer. Helix III flanking the C-terminal EF-hand is implicated to participate in the interaction of S100A2 and its target(s)...
  36. Schafer B, Wicki R, Engelkamp D, Mattei M, Heizmann C. Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Genomics. 1995;25:638-43 pubmed
    ..The new nomenclature should facilitate and further the understanding of this protein family and be easily expandable to other species. ..
  37. Wang T, Liang Y, Thakur A, Zhang S, Liu F, Khan H, et al. Expression and clinicopathological significance of S100 calcium binding protein A2 in lung cancer patients of Chinese Han ethnicity. Clin Chim Acta. 2017;464:118-122 pubmed publisher
    ..As an important member of this family, S100 calcium binding protein A2 (S100A2) has been confirmed to be associated with many biological processes, and has an abnormal expression in non-small ..
  38. Koch M, Diez J, Wagner A, Fritz G. Crystallization and calcium/sulfur SAD phasing of the human EF-hand protein S100A2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:1032-6 pubmed publisher
    Human S100A2 is an EF-hand protein and acts as a major tumour suppressor, binding and activating p53 in a Ca2+-dependent manner...
  39. Stemmler S, Nothnagel M, Parwez Q, Petrasch Parwez E, Epplen J, Hoffjan S. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. Int J Immunogenet. 2009;36:217-22 pubmed publisher
    ..Thus, in this German cohort, there is no evidence that additional genes in the EDC region apart from FLG contribute substantially to AD pathogenesis. ..
  40. Stoll S, Chia N, Nair R, Woods T, Stuart P, Henseler T, et al. S100A2 coding sequence polymorphism: characterization and lack of association with psoriasis. Clin Exp Dermatol. 2001;26:79-83 pubmed
    ..least 20 genes involved in epidermal differentiation and proliferation have been mapped to this region including S100A2, a gene known to be over-expressed in psoriasis lesions...
  41. van Dieck J, Fernandez Fernandez M, Veprintsev D, Fersht A. Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers. J Biol Chem. 2009;284:13804-11 pubmed publisher
    We investigated the ways S100B, S100A1, S100A2, S100A4, and S100A6 bind to the different oligomeric forms of the tumor suppressor p53 in vitro, using analytical ultracentrifugation and multiangle light scattering...
  42. Kumar M, Srivastava G, Kaur J, Assi J, Alyass A, Leong I, et al. Prognostic significance of cytoplasmic S100A2 overexpression in oral cancer patients. J Transl Med. 2015;13:8 pubmed publisher
    ..The aim of this study was to determine the prognostic significance of alterations in sub-cellular expression of S100A2, a pro-tumorigenic calcium binding protein, identified as a candidate biomarker in our proteomic analysis in OSCC ..
  43. Takata M, Shimamoto S, Yamaguchi F, Tokuda M, Tokumitsu H, Kobayashi R. Regulation of nuclear localization signal-importin ? interaction by Ca2+/S100A6. FEBS Lett. 2010;584:4517-23 pubmed publisher
    ..These results indicate S100A6 may regulate the nuclear transport of NLS-cargos in response to increasing concentrations of intracellular Ca(2+). ..
  44. Yamaguchi F, Tsuchiya M, Shimamoto S, Fujimoto T, Tokumitsu H, Tokuda M, et al. Oxidative Stress Impairs the Stimulatory Effect of S100 Proteins on Protein Phosphatase 5 Activity. Tohoku J Exp Med. 2016;240:67-78 pubmed publisher
    ..Recombinant S100A2 was easily air-oxidized or Cu-oxidized, and oxidized S100A2 formed cross-linked dimers and higher molecular-mass ..
  45. Diederichs S, Bulk E, Steffen B, Ji P, Tickenbrock L, Lang K, et al. S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer. Cancer Res. 2004;64:5564-9 pubmed
    ..g., matrix metalloproteinases). In addition, we found S100P, S100A2, trypsinogen C (TRY6), and trypsinogen IVb (PRSS3) to be overexpressed in tumors that metastasized during the ..
  46. Almadori G, Bussu F, Galli J, Rigante M, Lauriola L, Michetti F, et al. Diminished expression of S100A2, a putative tumour suppressor, is an independent predictive factor of neck node relapse in laryngeal squamous cell carcinoma. J Otolaryngol Head Neck Surg. 2009;38:16-22 pubmed
    In primary squamous cell carcinoma of the larynx (LSCC), Ca(2+) binding S100A2 protein underexpression was already found to be associated with poor tumour differentiation and shorter overall survival...
  47. van Dieck J, Lum J, Teufel D, Fersht A. S100 proteins interact with the N-terminal domain of MDM2. FEBS Lett. 2010;584:3269-74 pubmed publisher
    ..This interaction with MDM2 (2-125) is a general feature of S100 proteins; S100A1, S100A2, S100A4 and S100A6 also interact with MDM2 (2-125)...
  48. Strazisar M, Rott T, Glavac D. Frequent polymorphic variations but rare tumour specific mutations of the S100A2 on 1q21 in non-small cell lung cancer. Lung Cancer. 2009;63:354-9 pubmed publisher
    Contrary to the recent hypothesis that S100A2 is a tumour suppressor, no somatic mutations have yet been identified...
  49. Golouh R, Cufer T, Sadikov A, Nussdorfer P, Usher P, Brunner N, et al. The prognostic value of Stathmin-1, S100A2, and SYK proteins in ER-positive primary breast cancer patients treated with adjuvant tamoxifen monotherapy: an immunohistochemical study. Breast Cancer Res Treat. 2008;110:317-26 pubmed
    We recently found that DNA methylation of S100A2, spleen tyrosine kinase (SYK), and Stathmin-1 (STMN1) correlates with response to tamoxifen therapy in metastatic breast cancer...
  50. Kyriazanos I, Tachibana M, Dhar D, Shibakita M, Ono T, Kohno H, et al. Expression and prognostic significance of S100A2 protein in squamous cell carcinoma of the esophagus. Oncol Rep. 2002;9:503-10 pubmed
    The purpose of this study was to evaluate the expression of S100A2 Ca2+-binding protein and its prognostic significance in the management of squamous cell carcinoma of the esophagus...
  51. Wang G, Zhang S, Fernig D, Spiller D, Martin Fernandez M, Zhang H, et al. Heterodimeric interaction and interfaces of S100A1 and S100P. Biochem J. 2004;382:375-83 pubmed
    ..These results have revealed the similarities and the differences between the S100P homodimer and the S100A1/S100P heterodimer. ..
  52. Groves P, Finn B, Kuznicki J, Forsen S. A model for target protein binding to calcium-activated S100 dimers. FEBS Lett. 1998;421:175-9 pubmed
    ..We conclude that the differences are a result of modeling rather than a function of different target binding properties. A mechanism for target protein binding is suggested. ..
  53. Zha C, Jiang X, Peng S. iTRAQ-based quantitative proteomic analysis on S100 calcium binding protein A2 in metastasis of laryngeal cancer. PLoS ONE. 2015;10:e0122322 pubmed publisher
    ..Further validation of the differentially expressed proteins S100A2, KRT16, FGB and HSPB1 were carried out using quantitative real-time RT-PCR, immunoblot and immunohistochemistry...
  54. Suzuki F, Oridate N, Homma A, Nakamaru Y, Nagahashi T, Yagi K, et al. S100A2 expression as a predictive marker for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral cavity. Oncol Rep. 2005;14:1493-8 pubmed
    The purpose of this study was to discover whether S100A2 expression is associated with late cervical metastasis in patients with stage I and II invasive squamous cell carcinoma of the oral cavity...
  55. Zech V, Dlaska M, Tzankov A, Hilbe W. Prognostic and diagnostic relevance of hnRNP A2/B1, hnRNP B1 and S100 A2 in non-small cell lung cancer. Cancer Detect Prev. 2006;30:395-402 pubmed
    ..Moreover, S100 A2 and hnRNP A2/B1 confirmed to be valuable prognostic parameters. ..
  56. Nagy N, Hoyaux D, Gielen I, Schafer B, Pochet R, Heizmann C, et al. The Ca2+-binding S100A2 protein is differentially expressed in epithelial tissue of glandular or squamous origin. Histol Histopathol. 2002;17:123-30 pubmed publisher
    It has been previously shown that S100A2 is downregulated in tumor cells...
  57. Hoyaux D, Decaestecker C, Heizmann C, Vogl T, Schafer B, Salmon I, et al. S100 proteins in Corpora amylacea from normal human brain. Brain Res. 2000;867:280-8 pubmed
    ..A., we investigated, by immunohistochemistry, the presence of different S100 proteins (S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A8, S100A9, S100A12 and S100B) in C.A. from normal human brain...
  58. Cao L, Yin Y, Li H, Jiang Y, Zhang H. Expression and clinical significance of S100A2 and p63 in esophageal carcinoma. World J Gastroenterol. 2009;15:4183-8 pubmed
    To investigate the expression and clinical significance of S100A2 mRNA and protein, p63 protein in esophageal squamous cell carcinoma (ESCC) and their roles in carcinogenesis and progression of esophageal carcinoma (EC)...
  59. Smith S, Gugger M, Hoban P, Ratschiller D, Watson S, Field J, et al. S100A2 is strongly expressed in airway basal cells, preneoplastic bronchial lesions and primary non-small cell lung carcinomas. Br J Cancer. 2004;91:1515-24 pubmed
    b>S100A2 gene products were shown to be frequently and dramatically over-represented in non-small cell lung cancer (NSCLC) lesions over normal tissue by microarray analysis...
  60. Buckley N, D Costa Z, Kaminska M, Mullan P. S100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability. Cell Death Dis. 2014;5:e1070 pubmed publisher
    ..BRCA1, along with interacting ?Np63 proteins, transcriptionally upregulate the putative tumour suppressor protein, S100A2. Both BRCA1 and ?Np63 proteins are required for S100A2 expression...
  61. Matsubara D, Niki T, Ishikawa S, Goto A, Ohara E, Yokomizo T, et al. Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes. Cancer Sci. 2005;96:844-57 pubmed
    ..blot analyses of lung adenocarcinoma cell lines and bronchiolar epithelial cells (SAEC and NHBE) revealed that S100A2 and S100A4 were the most strikingly downregulated and upregulated members of the S100 family, respectively...
  62. Koch M, Diez J, Fritz G. Purification and crystallization of the human EF-hand tumour suppressor protein S100A2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006;62:1120-3 pubmed
    b>S100A2 is a Ca(2+)-binding EF-hand protein that is mainly localized in the nucleus. There, it acts as a tumour suppressor by binding and activating p53. Wild-type S100A2 and a S100A2 variant lacking cysteines have been purified...
  63. Li Y, Gudjonsson J, Woods T, Zhang T, Johnston A, Stoll S, et al. Transgenic expression of S100A2 in hairless mouse skin enhances Cxcl13 mRNA in response to solar-simulated radiation. Arch Dermatol Res. 2009;301:205-17 pubmed publisher
    b>S100A2 is a homodimeric protein that undergoes oxidative cross-linking and translocation from the nucleus to the cytosol in the context of oxidative stress...
  64. Biankin A, Kench J, Colvin E, Segara D, Scarlett C, Nguyen N, et al. Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer. Gastroenterology. 2009;137:558-68, 568.e1-11 pubmed publisher
    ..Of the 17 candidate biomarkers examined, only elevated expression of S100A2 was an independent predictor of survival in both the training (n = 162) and validation sets (n = 439; hazard ratio ..
  65. Nielsen K, Heegaard S, Vorum H, Birkenkamp Demtroder K, Ehlers N, Orntoft T. Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients. Cornea. 2005;24:661-8 pubmed
    This investigation was designed to determine whether the five genes, CLC, DSG3, EMP3, S100A2 and SLPI, are differentially expressed in keratoconus, as indicated from another study...
  66. Lee O, Hong S, Razvi M, Peng D, Powell S, Smoklin M, et al. Expression of calcium-binding proteins S100A2 and S100A4 in Barrett's adenocarcinomas. Neoplasia. 2006;8:843-50 pubmed
    In this study, we investigated the mRNA and protein expression of S100A2 and S100A4 in adenocarcinomas of the stomach and esophagus...
  67. Koch M, Bhattacharya S, Kehl T, Gimona M, Vasak M, Chazin W, et al. Implications on zinc binding to S100A2. Biochim Biophys Acta. 2007;1773:457-70 pubmed
    Human S100A2 is an EF-hand calcium-binding S100 protein that is localized mainly in the nucleus and functions as tumor suppressor. In addition to Ca2+ S100A2 binds Zn2+ with a high affinity...
  68. Chivu Economescu M, Necula L, Dragu D, Badea L, Dima S, Tudor S, et al. Identification of potential biomarkers for early and advanced gastric adenocarcinoma detection. Hepatogastroenterology. 2010;57:1453-64 pubmed
    ..This study aimed to understand gradual biological variations during gastric tumorigenesis, and to identify the candidate genes that are involved in tumor progression and metastasis...
  69. Li H, Zhang M, Chen L, Zhang B, Zhang C. Expression of S100A2 and S100P in human eccrine sweat glands and their application in differentiating secretory coil-like from duct-like structures in the 3D reconstituted eccrine sweat spheroids. J Mol Histol. 2017;48:219-223 pubmed publisher
    ..In this study, we first examined the co-localization of K5/K7, ?-SMA/K14, K7/S100P and ?-SMA/S100A2 by double-immunofluorescence staining to confirm the localization of S100P and S100A2 in native human eccrine ..
  70. Gimona M, Lando Z, Dolginov Y, Vandekerckhove J, Kobayashi R, Sobieszek A, et al. Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins. J Cell Sci. 1997;110 ( Pt 5):611-21 pubmed
    ..with 1-ethyl-3-[3-(dimethyl amino)propyl]carbodiimide (EDC) indicated an association of the Ca2+-binding protein S100A2 with tropomyosin (TM) in vitro...