Gene Symbol: S100A12
Description: S100 calcium binding protein A12
Alias: CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, protein S100-A12, EN-RAGE, calcitermin, calcium-binding protein in amniotic fluid 1, calgranulin C, extracellular newly identified RAGE-binding protein, migration inhibitory factor-related protein 6, neutrophil S100 protein
Species: human
Products:     S100A12

Top Publications

  1. Guignard F, Mauel J, Markert M. Identification and characterization of a novel human neutrophil protein related to the S100 family. Biochem J. 1995;309 ( Pt 2):395-401 pubmed
    ..The Ca(2+)-dependent translocation of the novel S100 protein in parallel with MRP-8 and MRP-14 suggests a role for these proteins in regulating the Ca2+ signal to the membrane cytoskeleton and thus in regulating neutrophil activation. ..
  2. Xie J, Burz D, He W, Bronstein I, Lednev I, Shekhtman A. Hexameric calgranulin C (S100A12) binds to the receptor for advanced glycated end products (RAGE) using symmetric hydrophobic target-binding patches. J Biol Chem. 2007;282:4218-31 pubmed
    b>Calgranulin C (S100A12) is a member of the S100 family of proteins that undergoes a conformational change upon calcium binding allowing them to interact with target molecules and initiate biological responses; one such target is the ..
  3. Yan W, Armishaw C, Goyette J, Yang Z, Cai H, Alewood P, et al. Mast cell and monocyte recruitment by S100A12 and its hinge domain. J Biol Chem. 2008;283:13035-43 pubmed publisher
    b>S100A12 is expressed at sites of acute, chronic, and allergic inflammation...
  4. Pietzsch J, Hoppmann S. Human S100A12: a novel key player in inflammation?. Amino Acids. 2009;36:381-9 pubmed publisher
    b>S100A12 is a member of the S100 family of EF-hand calcium-binding proteins...
  5. Moroz O, Antson A, Grist S, Maitland N, Dodson G, Wilson K, et al. Structure of the human S100A12-copper complex: implications for host-parasite defence. Acta Crystallogr D Biol Crystallogr. 2003;59:859-67 pubmed
    b>S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins. Together with S100A8 and S100A9, it belongs to the calgranulin subfamily, i.e...
  6. Nakashima A, Carrero J, Qureshi A, Miyamoto T, Anderstam B, Barany P, et al. Effect of circulating soluble receptor for advanced glycation end products (sRAGE) and the proinflammatory RAGE ligand (EN-RAGE, S100A12) on mortality in hemodialysis patients. Clin J Am Soc Nephrol. 2010;5:2213-9 pubmed publisher
    ..In contrast, the RAGE ligand S100A12 (also known as EN-RAGE) contributes to inflammation and the development of atherosclerosis in animal models...
  7. Hofmann M, Drury S, Fu C, Qu W, Taguchi A, Lu Y, et al. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999;97:889-901 pubmed
    ..These data highlight a novel paradigm in inflammation and identify roles for EN-RAGEs and RAGE in chronic cellular activation and tissue injury. ..
  8. Moroz O, Antson A, Murshudov G, Maitland N, Dodson G, Wilson K, et al. The three-dimensional structure of human S100A12. Acta Crystallogr D Biol Crystallogr. 2001;57:20-9 pubmed
    The crystal structure of human EF-hand calcium-binding protein S100A12 in its calcium-bound form has been determined to 1.95 A resolution by molecular replacement using the structure of the S100B protein...
  9. Hsieh H, Schafer B, Weigle B, Heizmann C. S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells. Biochem Biophys Res Commun. 2004;316:949-59 pubmed
    ..These experiments suggest a common cell surface receptor for S100 proteins on endothelial cells even though intracellular translocation induced by extracellular S100 proteins is specific. ..

More Information

Publications109 found, 100 shown here

  1. Shepherd C, Goyette J, Utter V, Rahimi F, Yang Z, Geczy C, et al. Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease. Neurobiol Aging. 2006;27:1554-63 pubmed
    ..S100A8, S100A9 and S100A12 comprise a new group of inflammation-associated proteins that are constitutively expressed by neutrophils and ..
  2. Mori Y, Kosaki A, Kishimoto N, Kimura T, Iida K, Fukui M, et al. Increased plasma S100A12 (EN-RAGE) levels in hemodialysis patients with atherosclerosis. Am J Nephrol. 2009;29:18-24 pubmed publisher
    b>S100A12, also known as EN-RAGE (extracellular newly identified receptor for advanced glycation end products binding protein) is a ligand for RAGE, and has been proposed to contribute to the development of atherosclerosis...
  3. Chen Y, Yan W, Geczy C, Brown M, Thomas R. Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis. Arthritis Res Ther. 2009;11:R39 pubmed publisher
    ..concentrations of three of its putative proinflammatory ligands, S100A8/A9 complex (calprotectin), S100A8, and S100A12, are found in rheumatoid arthritis (RA) serum and synovial fluid...
  4. Hoppmann S, Steinbach J, Pietzsch J. Scavenger receptors are associated with cellular interactions of S100A12 in vitro and in vivo. Int J Biochem Cell Biol. 2010;42:651-61 pubmed publisher
    ..a novel methodology using recombinant human S100 proteins radiolabelled with fluorine-18, particularly, (18)F-S100A12, in receptor binding studies and cellular association studies in vitro, and in dynamic small animal positron ..
  5. HOFMANN BOWMAN M, Gawdzik J, Bukhari U, Husain A, Toth P, Kim G, et al. S100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein E-null mice by activating an osteogenic gene regulatory program. Arterioscler Thromb Vasc Biol. 2011;31:337-44 pubmed publisher
    The proinflammatory cytokine S100A12 is associated with coronary atherosclerotic plaque rupture...
  6. Marti T, Erttmann K, Gallin M. Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. Biochem Biophys Res Commun. 1996;221:454-8 pubmed
    A novel S100 ca2+-binding protein, termed calgranulin-related protein (CGRP), was purified to homogeneity from extracts of adult Onchocerca volvulus, a human tissue-dwelling parasite...
  7. Foell D, Ichida F, Vogl T, Yu X, Chen R, Miyawaki T, et al. S100A12 (EN-RAGE) in monitoring Kawasaki disease. Lancet. 2003;361:1270-2 pubmed
    The calcium-binding protein S100A12 causes inflammation through interaction with the multiligand receptor for advanced glycation end products (RAGE). Blocking of S100A12 showed promising therapeutic effects in mice...
  8. Foell D, Kucharzik T, Kraft M, Vogl T, Sorg C, Domschke W, et al. Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease. Gut. 2003;52:847-53 pubmed
    ..b>S100A12 is a calcium binding protein with proinflammatory properties...
  9. Goyette J, Yan W, Yamen E, Chung Y, Lim S, Hsu K, et al. Pleiotropic roles of S100A12 in coronary atherosclerotic plaque formation and rupture. J Immunol. 2009;183:593-603 pubmed publisher
    ..The Ca(2+)-binding protein S100A12 regulates monocyte migration and may contribute to atherosclerosis by inducing proinflammatory cytokines in ..
  10. Shiotsu Y, Mori Y, Nishimura M, Sakoda C, Tokoro T, Hatta T, et al. Plasma S100A12 level is associated with cardiovascular disease in hemodialysis patients. Clin J Am Soc Nephrol. 2011;6:718-23 pubmed publisher
    b>S100A12 is an endogenous receptor ligand for advanced glycation end products. Cardiovascular disease remains a major cause of morbidity and mortality in patients with chronic kidney disease...
  11. Däbritz J, Jenke A, Wirth S, Foell D. Fecal phagocyte-specific S100A12 for diagnosing necrotizing enterocolitis. J Pediatr. 2012;161:1059-64 pubmed publisher
    To determine whether longitudinal measurements of fecal S100A12, a fecal marker of intestinal inflammation, can identify very low birth weight infants at risk for necrotizing enterocolitis (NEC)...
  12. Moroz O, Antson A, Dodson E, Burrell H, Grist S, Lloyd R, et al. The structure of S100A12 in a hexameric form and its proposed role in receptor signalling. Acta Crystallogr D Biol Crystallogr. 2002;58:407-13 pubmed
    b>S100A12 is a member of the S100 subfamily of EF-hand calcium-binding proteins; it has been shown to be one of the ligands of the 'receptor for advanced glycation end products' (RAGE) that belongs to the immunoglobulin superfamily and is ..
  13. Wittkowski H, Hirono K, Ichida F, Vogl T, Ye F, Yanlin X, et al. Acute Kawasaki disease is associated with reverse regulation of soluble receptor for advance glycation end products and its proinflammatory ligand S100A12. Arthritis Rheum. 2007;56:4174-81 pubmed
    ..g., S100A12. This neutrophil-derived protein has been reported to be associated with Kawasaki disease (KD) and to provoke ..
  14. Brzozowski T, Ptak Belowska A, Kwiecien S, Krzysiek Maczka G, Strzalka M, Drozdowicz D, et al. Novel concept in the mechanism of injury and protection of gastric mucosa: role of renin-angiotensin system and active metabolites of angiotensin. Curr Med Chem. 2012;19:55-62 pubmed
    ..factor alpha (TGF?), vasodilatory mediators such as nitric oxide (NO) and calcitonin gene related peptide (CGRP) as well as appetite gut hormones including gastrin and cholecystokinin (CCK), leptin and recently ghrelin...
  15. Czekaj R, Majka J, Ptak Belowska A, Szlachcic A, Targosz A, Magierowska K, et al. Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides. J Physiol Pharmacol. 2016;67:261-75 pubmed
    ..with capsaicin denervation were restored by concomitant treatment with exogenous calcitonin gene related pepetide (CGRP) combined with curcumin and subsequently exposed to WRS...
  16. Magierowski M, Hubalewska Mazgaj M, Magierowska K, Wójcik D, Sliwowski Z, Kwiecien S, et al. Nitric oxide, afferent sensory nerves, and antioxidative enzymes in the mechanism of protection mediated by tricarbonyldichlororuthenium(II) dimer and sodium hydrosulfide against aspirin-induced gastric damage. J Gastroenterol. 2018;53:52-63 pubmed publisher
    ..We determined the involvement of afferent sensory neurons, calcitonin-gene-related peptide (CGRP), lipid peroxidation, and nitric oxide (NO) biosynthesis in gastroprotection of H2S-releasing NaHS and ..
  17. Sand E, Roth B, Weström B, Bonn P, Ekblad E, Ohlsson B. Structural and functional consequences of buserelin-induced enteric neuropathy in rat. BMC Gastroenterol. 2014;14:209 pubmed publisher
    ..The relative numbers of neurons containing calcitonin gene-related peptide (CGRP), cocaine- and amphetamine-related transcript (CART), galanin, gastrin-releasing peptide (GRP), neuropeptide Y (NPY)..
  18. Zhang B, Li S, Xie H, Fan J, Gu C, Kang C, et al. Effects of silencing the DUSP1 gene using lentiviral vector-mediated siRNA on the release of proinflammatory cytokines through regulation of the MAPK signaling pathway in mice with acute pancreatitis. Int J Mol Med. 2018;41:2213-2224 pubmed publisher
    ..including tumor necrosis factor (TNF)??, interleukin (IL)?1? and IL?6, high mobility group box 1 (HMGB1), and S100A12 in serum samples were detected using an enzyme?linked immunosorbent assay at 12, 24 and 48 h post?modeling...
  19. Choi J, Di Nardo A. Skin neurogenic inflammation. Semin Immunopathol. 2018;40:249-259 pubmed publisher
    ..Neuropeptides, like substance P (SP) and calcitonin gene-related protein (CGRP), are produced by sensory nerves in the dermis; they induce mast cells to release vasoactive amines that facilitate ..
  20. Mambretti E, Kistner K, Mayer S, Massotte D, Kieffer B, Hoffmann C, et al. Functional and structural characterization of axonal opioid receptors as targets for analgesia. Mol Pain. 2016;12: pubmed publisher
    ..Double immunolabeling documented that MOP immunoreactivity was confined to calcitonin gene-related peptide (CGRP) positive fibers and fiber bundles...
  21. Yuan L, Qin Y, Wang L, Zeng Y, Chang H, Wang J, et al. Capsaicin-containing chili improved postprandial hyperglycemia, hyperinsulinemia, and fasting lipid disorders in women with gestational diabetes mellitus and lowered the incidence of large-for-gestational-age newborns. Clin Nutr. 2016;35:388-393 pubmed publisher
    ..2-h INS), and fasting serum lipids, liver and kidney function parameters, and calcitonin gene-related peptide (CGRP) were measured at 0 and 4 weeks. The maternal and neonatal outcomes were also recorded...
  22. Kwiecien S, Magierowska K, Magierowski M, Surmiak M, Hubalewska Mazgaj M, Pajdo R, et al. Role of sensory afferent nerves, lipid peroxidation and antioxidative enzymes in the carbon monoxide-induced gastroprotection against stress ulcerogenesis. J Physiol Pharmacol. 2016;67:717-729 pubmed
    ..however, the involvement of the capsaicin-sensitive afferent neurons releasing calcitonin gene related peptide (CGRP) and anti-oxidative factors and mechanisms in the CO-induced gastroprotection against stress ulcerogenesis has been ..
  23. Hou M, Tang Q, Xue Q, Zhang X, Liu Y, Yang S, et al. Pharmacodynamic action and mechanism of Du Liang soft capsule, a traditional Chinese medicine capsule, on treating nitroglycerin-induced migraine. J Ethnopharmacol. 2017;195:231-237 pubmed publisher
    ..Plasma calcitonin gene related to peptide (CGRP) and endothelin (ET) levels were measured using the radioimmunoassay method, and serum NO was determined by the ..
  24. Yamaguchi T, Ochiai N, Sasaki Y, Kijima T, Hashimoto E, Sasaki Y, et al. Efficacy of hyaluronic acid or steroid injections for the treatment of a rat model of rotator cuff injury. J Orthop Res. 2015;33:1861-7 pubmed publisher
    ..dorsal root ganglia from C3-C7, analyzed gait, and compared the expression of calcitonin gene-related peptide (CGRP) which was a marker of inflammatory pain in a rat rotator cuff tear model in which the supraspinatus and ..
  25. Wilsmann Theis D, Wagenpfeil J, Holzinger D, Roth J, Koch S, Schnautz S, et al. Among the S100 proteins, S100A12 is the most significant marker for psoriasis disease activity. J Eur Acad Dermatol Venereol. 2016;30:1165-70 pubmed publisher
    ..The aim of this study was to evaluate the impact of S100A7, S100A8, S100A9 and S100A12 as possible markers for disease activity in patients with psoriasis skin disease...
  26. Hunt W, Helfman B, McCarty N, Hansen J. Advanced glycation end products are elevated in cystic fibrosis-related diabetes and correlate with worse lung function. J Cyst Fibros. 2016;15:681-8 pubmed publisher
    ..Plasma RAGE ligands (i.e. advanced glycation end products, S100A12, and high-mobility group protein B1) and soluble RAGE (sRAGE) levels were measured...
  27. Roman C, Derkach V, Palmiter R. Genetically and functionally defined NTS to PBN brain circuits mediating anorexia. Nat Commun. 2016;7:11905 pubmed publisher
    ..We previously described a neural circuit for appetite suppression involving calcitonin gene-related protein (CGRP)-expressing PBN (CGRP(PBN)) neurons; however, the molecular identity of the inputs to these neurons was not ..
  28. Schmitt L, Amann P, Marquardt Y, Heise R, Czaja K, Gerber P, et al. Molecular effects of fractional ablative erbium:YAG laser treatment with multiple stacked pulses on standardized human three-dimensional organotypic skin models. Lasers Med Sci. 2017;32:805-814 pubmed publisher
    ..protein 4, filaggrin, filaggrin 2, and loricrin, and antimicrobial peptides (S100A7A, S100A9, and S100A12) as well as CASP14, DSG2, IL18, and IL36? was reduced...
  29. Hofmann Bowman M, Wilk J, Heydemann A, Kim G, Rehman J, Lodato J, et al. S100A12 mediates aortic wall remodeling and aortic aneurysm. Circ Res. 2010;106:145-54 pubmed publisher
    b>S100A12 is a small calcium binding protein that is a ligand of RAGE (receptor for advanced glycation end products)...
  30. Alhadeff A, Holland R, Nelson A, Grill H, De Jonghe B. Glutamate Receptors in the Central Nucleus of the Amygdala Mediate Cisplatin-Induced Malaise and Energy Balance Dysregulation through Direct Hindbrain Projections. J Neurosci. 2015;35:11094-104 pubmed publisher
    ..DVC neurons that project to the lPBN and a population of cisplatin-activated lPBN calcitonin gene-related peptide (CGRP, a marker for glutamatergic neurons in the lPBN) neurons that project to the CeA, outlining a neuroanatomical ..
  31. Loktionov A, Chhaya V, Bandaletova T, Poullis A. Inflammatory bowel disease detection and monitoring by measuring biomarkers in non-invasively collected colorectal mucus. J Gastroenterol Hepatol. 2017;32:992-1002 pubmed publisher
    ..Calprotectin, eosinophil-derived neurotoxin (EDN), and protein S100A12 were measured in colorectal mucus self-collected following defecation by 58 patients with IBD (before therapy), ..
  32. Kilinc E, Guerrero Toro C, Zakharov A, Vitale C, Gubert Olivé M, Koroleva K, et al. Serotonergic mechanisms of trigeminal meningeal nociception: Implications for migraine pain. Neuropharmacology. 2017;116:160-173 pubmed publisher
    ..5-HT also triggered peripheral CGRP release in meninges, which was blocked by MDL-72222...
  33. He W, Wang X, Shi H, Bai W, Cheng B, Su Y, et al. Cutaneous neurogenic inflammation in the sensitized acupoints induced by gastric mucosal injury in rats. BMC Complement Altern Med. 2017;17:141 pubmed publisher
    ..Immnohistochemistry analysis was used to detect the expression of calcitonin gene-related peptide (CGRP)- or substance P (SP)-labeled nerve fibers, histamine (HA)-, serotonin (5-HT)-, and tryptase-labeled cells in EB ..
  34. Martelletti P. The Application of CGRP(r) Monoclonal Antibodies in Migraine Spectrum: Needs and Priorities. BioDrugs. 2017;31:483-485 pubmed publisher
    ..We will, lastly, be able to rehabilitate these patients to achieve a quality working and social life, and facilitate their reintegration into daily normality. ..
  35. Srikrishna G, Nayak J, Weigle B, Temme A, Foell D, Hazelwood L, et al. Carboxylated N-glycans on RAGE promote S100A12 binding and signaling. J Cell Biochem. 2010;110:645-59 pubmed publisher
    ..we study the role of these glycans on the binding and intracellular signaling mediated by another RAGE ligand, S100A12. S100A12 binds carboxylated glycans, and a subpopulation of RAGE enriched for carboxylated glycans shows more ..
  36. Keppler D. Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy. Handb Exp Pharmacol. 2011;:299-323 pubmed publisher
    ..with conjugated hyperbilirubinemia in Dubin-Johnson syndrome, in pseudoxanthoma elasticum due to mutations in the MRP6 (ABCC6) gene, or in the type of human earwax and osmidrosis determined by single nucleotide polymorphisms in the ..
  37. Suzuki M, Inage K, Sakuma Y, Orita S, Yamauchi K, Suzuki T, et al. Effect of administration of antibodies against nerve growth factor in a rat model of muscle injury. Injury. 2016;47:609-12 pubmed publisher
    ..of FG-positive cells that were also positive for a pain-related neuropeptide, calcitonin gene-related peptide (CGRP), was determined for the bilateral dorsal root ganglia from L1 to L6 7 days post-injury...
  38. St Jacques B, Ma W. Preferred recycling pathway by internalized PGE2 EP4 receptor following agonist stimulation in cultured dorsal root ganglion neurons contributes to enhanced EP4 receptor sensitivity. Neuroscience. 2016;326:56-68 pubmed publisher
    ..Double exposures to 1-OH-PGE1 induced a greater increase in calcitonin gene-related peptide (CGRP) release than a single exposure or vehicle exposure, an event blocked by pre-treatment with the recycling inhibitor ..
  39. Pfeil U, Bharathala S, Murtaza G, Mermer P, Papadakis T, Boening A, et al. Spatial expression of components of a calcitonin receptor-like receptor (CRL) signalling system (CRL, calcitonin gene-related peptide, adrenomedullin, adrenomedullin-2/intermedin) in mouse and human heart valves. Cell Tissue Res. 2016;366:587-599 pubmed
    ..mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3...
  40. Sun J, Wu X, Meng Y, Cheng J, Ning H, Peng Y, et al. Electro-acupuncture decreases 5-HT, CGRP and increases NPY in the brain-gut axis in two rat models of Diarrhea-predominant irritable bowel syndrome(D-IBS). BMC Complement Altern Med. 2015;15:340 pubmed publisher
    ..whether electro-acupuncture (EA) could decrease 5-hydroxytryptamine (5-HT) and calcitonin gene-related peptide (CGRP), and increase neuro-peptide Y (NPY) in the brain-gut axis (BGA) in D-IBS using rat models...
  41. Palus K, Całka J. The Influence of Prolonged Acetylsalicylic Acid Supplementation-Induced Gastritis on the Neurochemistry of the Sympathetic Neurons Supplying Prepyloric Region of the Porcine Stomach. PLoS ONE. 2015;10:e0143661 pubmed publisher
    ..LENK), cocaine- and amphetamine- regulated transcript peptide (CART), calcitonin gene-related peptide (CGRP), substance P (SP) and vasoactive intestinal peptide (VIP)...
  42. Assas B, Wakid M, Zakai H, Miyan J, Pennock J. Transient receptor potential vanilloid 1 expression and function in splenic dendritic cells: a potential role in immune homeostasis. Immunology. 2016;147:292-304 pubmed publisher
    ..receptor potential vanilloid 1 (TRPV1) on sensory nerves induces the release of calcitonin-gene-related peptide (CGRP), a neuropeptide known to moderate dendritic cell activation and T helper cell type 1 polarization...
  43. Salio C, Ferrini F. BDNF and GDNF expression in discrete populations of nociceptors. Ann Anat. 2016;207:55-61 pubmed publisher
    ..neurons are of the peptidergic type; (3) BDNF-IR neurons are a subpopulation of calcitonin gene-related peptide (CGRP)-IR neurons (41.3±0.4%), also positive for substance P (SP) (42.3±0...
  44. Lu C, Qiu T, Liu Z, Su L, Cheng B. Calcitonin gene-related peptide has protective effect on brain injury induced by heat stroke in rats. Exp Ther Med. 2017;14:4935-4941 pubmed publisher
    ..In recent years, calcitonin gene-related peptide (CGRP) has been considered to have a positive role in central nervous system injury...
  45. Bai J, Zhang Y, Wang Y, Lan J, Li X. [Overexpression of TRPV1 after periphery nerve injury attenuates nerve regeneration in rats]. Zhonghua Bing Li Xue Za Zhi. 2017;46:847-852 pubmed publisher
    ..The injury only group was injected the same volume of medium. The release of CGRP from dorsal-horn of spinal cord, the number of axons at proximal stem of sciatic nerve after transection, and the ..
  46. Gohar F, Anink J, Moncrieffe H, van Suijlekom Smit L, Prince F, van Rossum M, et al. S100A12 Is Associated with Response to Therapy in Juvenile Idiopathic Arthritis. J Rheumatol. 2018;45:547-554 pubmed publisher
    ..complex 8/14 (MRP8/14) is associated with therapeutic response, we tested granulocyte-specific S100-protein S100A12 as a potential biomarker for treatment response...
  47. Stefanidis A, Wiedmann N, Tyagi S, Allen A, Watt M, Oldfield B. Insights into the neurochemical signature of the Innervation of Beige Fat. Mol Metab. 2018;11:47-58 pubmed publisher
    ..upregulation of genes encoding neuropeptides proopiomelanocortin (POMC) and calcitonin-gene related peptide (CGRP) within ganglionic neurons...
  48. Guo Z, Liu N, Chen L, Zhao X, Li M. Independent roles of CGRP in cardioprotection and hemodynamic regulation in ischemic postconditioning. Eur J Pharmacol. 2018;828:18-25 pubmed publisher
    Calcitonin gene-related peptide (CGRP) may participate in ischemic post-conditioning (IPost) attenuating myocardial ischemia/reperfusion injury. However, the molecular mechanism underlying the effect of CGRP is still elusive...
  49. Robinson D, Segal M, Halperin N, Nevo Z. Neuropeptidergic innervation of intramuscular hemangiomas. Exp Mol Pathol. 1992;56:186-96 pubmed
    ..Furthermore, hemangiomas contain a significantly higher number of calcitonin gene-related peptide (CGRP), substance P, and Met-enkephalin-positive fibers...
  50. Klingelhofer J, Senolt L, Baslund B, Nielsen G, Skibshøj I, Pavelka K, et al. Up-regulation of metastasis-promoting S100A4 (Mts-1) in rheumatoid arthritis: putative involvement in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 2007;56:779-89 pubmed
    ..The pattern of S100A4 expression differed significantly from that of the proinflammatory proteins S100A9 and S100A12, which were restricted to phagocytes and granulocytes...
  51. de Koning H, Schalkwijk J, Stoffels M, Jongekrijg J, Jacobs J, Verwiel E, et al. The role of interleukin-1 beta in the pathophysiology of Schnitzler's syndrome. Arthritis Res Ther. 2015;17:187 pubmed publisher
    ..IL-6 levels in serum and in lysates of freshly isolated PBMCs and serum myeloid-related protein (MRP8)/14 and S100A12 levels correlated with disease activity...
  52. Sulzberger M, Worthmann A, Holtzmann U, Buck B, Jung K, Schoelermann A, et al. Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A. J Eur Acad Dermatol Venereol. 2016;30 Suppl 1:9-17 pubmed publisher
    ..the release of PGE2 and activation of NFκB and to (ii) inhibit TRPV1 activation or the release of neuronal CGRP. To assess subjective and objective symptoms of skin sensitivity in vivo, two controlled, single-blind, randomized ..
  53. Pichichero M, Almudevar A. Serum cytokine biomarkers accurately predict presence of acute otitis media infection and recovery caused by Haemophilus influenzae. Int J Pediatr Otorhinolaryngol. 2016;83:200-4 pubmed publisher
    ..Immunoassays were used to quantitate serum S100A12, IL-10 and sICAM-1 cytokine levels. Middle ear fluids permitted identification of otopathogens...
  54. Jiang W, Wang Z, Hu Z, Wu H, Hu R, Hu X, et al. Blocking the ERK1/2 signal pathway can inhibit S100A12 induced human aortic smooth muscle cells damage. Cell Biol Int. 2017;41:1307-1315 pubmed publisher
    Increased levels of S100A12 and activated matrix metalloproteinase 2/9 (MMP-2/9) produced by human aortic smooth muscle cells (HASMCs) have recently implicated in the development of thoracic aortic disease...
  55. Li Y, Zhang H, Kosturakis A, Cassidy R, Zhang H, Kennamer Chapman R, et al. MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy. Brain Behav Immun. 2015;49:255-66 pubmed publisher
    ..Phospho-ERK1/2 staining was co-localized to small CGRP-positive DRG neurons in cell profiles surrounding large DRG neurons consistent with satellite glial cells...
  56. Waltman L, Runke C, Balcom J, Riley J, Lilley M, Christian S, et al. Further Defining the Role of the Laboratory Genetic Counselor. J Genet Couns. 2016;25:786-98 pubmed publisher
    ..of the National Society of Genetic Counselors (NSGC) and the Canadian Association of Genetic Counsellors (CAGC)...
  57. Giamberardino M, Affaitati G, Curto M, Negro A, Costantini R, Martelletti P. Anti-CGRP monoclonal antibodies in migraine: current perspectives. Intern Emerg Med. 2016;11:1045-1057 pubmed
    ..Mechanism-based therapies are, therefore, needed. Calcitonin gene-related peptide (CGRP) is recognized as crucial in the pathophysiology of migraine, and new compounds that target the peptide have been ..
  58. Yegutkin G, Guerrero Toro C, Kilinc E, Koroleva K, Ishchenko Y, Abushik P, et al. Nucleotide homeostasis and purinergic nociceptive signaling in rat meninges in migraine-like conditions. Purinergic Signal. 2016;12:561-74 pubmed publisher
    ..in rat meninges and in cultured trigeminal cells exposed to the migraine mediator calcitonin gene-related peptide (CGRP)...
  59. González Hernández A, Marichal Cancino B, Lozano Cuenca J, López Canales J, Muñoz Islas E, Ramírez Rosas M, et al. Heteroreceptors Modulating CGRP Release at Neurovascular Junction: Potential Therapeutic Implications on Some Vascular-Related Diseases. Biomed Res Int. 2016;2016:2056786 pubmed publisher
    Calcitonin gene-related peptide (CGRP) is a 37-amino-acid neuropeptide belonging to the calcitonin gene peptide superfamily. CGRP is a potent vasodilator with potential therapeutic usefulness for treating vascular-related disease...
  60. Naito Y, Wakabayashi H, Kato S, Nakagawa T, Iino T, Sudo A. Alendronate inhibits hyperalgesia and suppresses neuropeptide markers of pain in a mouse model of osteoporosis. J Orthop Sci. 2017;22:771-777 pubmed publisher
    ..Transient receptor potential channel vanilloid 1 (TRPV1) and calcitonin gene-related peptide (CGRP) expressions in L3-5 dorsal root ganglion (DRG) neurons were examined immunohistochemically...
  61. Hannivoort R, Dunning S, Vander Borght S, Schroyen B, Woudenberg J, Oakley F, et al. Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells. Hepatology. 2008;48:624-34 pubmed publisher
    ..of Mrp3, Mrp4, Mdr1a, and Mdr1b but not the hepatocyte-specific transporters bile salt export pump, Mrp2, and Mrp6. Mrp1 protein staining correlated with desmin staining in livers from CCl(4)-treated rats...
  62. Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Du Yan S, et al. N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression. J Biol Chem. 1999;274:31740-9 pubmed
    ..Thus, CML-RAGE interaction triggers processes intimately linked to accelerated vascular and inflammatory complications that typify disorders in which inflammation is an established component. ..
  63. Mahajan N, Bahl A, Dhawan V. C-reactive protein (CRP) up-regulates expression of receptor for advanced glycation end products (RAGE) and its inflammatory ligand EN-RAGE in THP-1 cells: inhibitory effects of atorvastatin. Int J Cardiol. 2010;142:273-8 pubmed publisher
    ..b>Extracellular newly identified RAGE binding protein (EN-RAGE), natural pro-inflammatory ligand for RAGE...
  64. Cornelison L, Hawkins J, Durham P. Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neurons. Neuroscience. 2016;339:491-501 pubmed publisher
    ..The goal of this study was to investigate the role of calcitonin gene-related peptide (CGRP) in promoting bidirectional signaling within the trigeminal system to mediate sensitization of primary nociceptive ..
  65. Pinkney A, Lemmey H, Dora K, Garland C. Vasorelaxation to the Nitroxyl Donor Isopropylamine NONOate in Resistance Arteries Does Not Require Perivascular Calcitonin Gene-Related Peptide. Hypertension. 2017;: pubmed publisher
    ..recently, Angeli's salt vasodilation was suggested to be indirect and caused by calcitonin gene-related peptide (CGRP) released from perivascular nerves after HNO activates TRPA1 (transient receptor potential cation channel subfamily ..
  66. Vegas O, Poligone B, Blackcloud P, Gilmore E, VanBuskirk J, Ritchlin C, et al. Chronic social stress Ameliorates psoriasiform dermatitis through upregulation of the Hypothalamic-Pituitary-Adrenal axis. Brain Behav Immun. 2018;68:238-247 pubmed publisher
    ..we found elevated pro-inflammatory neuropeptide production of substance P (SP), calcitonin-gene-related peptide (CGRP) and nerve-growth factor (NGF) mRNA in the dorsal root ganglia (DRG) as well as pro-inflammatory cytokines in ..
  67. Hathway G, Murphy E, Lloyd J, Greenspon C, Hulse R. Cancer Chemotherapy in Early Life Significantly Alters the Maturation of Pain Processing. Neuroscience. 2018;387:214-229 pubmed publisher
    ..The percentage of IB4+ve, CGRP+ve and NF200+ve DRG neurons was not different between groups at P45...
  68. Filipek A, Jastrzebska B, Nowotny M, Kuznicki J. CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. J Biol Chem. 2002;277:28848-52 pubmed
    ..125I-CacyBP/SIP and CacyBP/SIP affinity chromatography, we found that this protein binds purified S100A1, S100A6, S100A12, S100B, and S100P but not S100A4, calbindin D(9k), parvalbumin, and calmodulin...
  69. de Jong N, Leach S, Day A. Fecal S100A12: a novel noninvasive marker in children with Crohn's disease. Inflamm Bowel Dis. 2006;12:566-72 pubmed
    The calcium-binding protein S100A12 is related to calprotectin, a protein shown to be a useful marker of gut inflammation...
  70. Fu S, Gong F, Xie C, Zhu W, Wang W, Shen H, et al. S100A12 on circulating endothelial cells surface in children with Kawasaki disease. Pediatr Res. 2010;68:165-8 pubmed publisher
    The purpose of this study was to investigate the expression of S100A12 on the surface of circulating endothelial cells (CECs) in children with Kawasaki disease (KD) and the correlations between S100A12 and coronary artery lesions (CALs)...
  71. Johnson C, Miller G, Baker B, Hollander M, Kashon M, Waugh S, et al. Changes in the expression of calcitonin gene-related peptide after exposure to injurious stretch-shortening contractions. Exp Gerontol. 2016;79:1-7 pubmed publisher
    ..cycles (iSSCs), resulted in hyperalgesia in the hind limb and changes in calcitonin-gene related peptide (CGRP) immunolabeling in the dorsal root ganglia (DRG) in young and old male rats...
  72. Tondera C, Laube M, Pietzsch J. Insights into binding of S100 proteins to scavenger receptors: class B scavenger receptor CD36 binds S100A12 with high affinity. Amino Acids. 2017;49:183-191 pubmed publisher
    The EF-hand type calcium-binding protein S100A12 exerts numerous intra- and extracellular functions of (patho)physiological relevance. Therefore, receptors of S100A12 are of high interest for research and clinical applications...
  73. Nordal H, Brokstad K, Solheim M, Halse A, Kvien T, Hammer H. Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis. Arthritis Res Ther. 2017;19:3 pubmed publisher
    Calprotectin (S100A8/A9 or MRP8/14) and S100A12 (leukocyte-derived proteins), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) are markers of inflammation and angiogenesis...
  74. Collins A, Li D, McMahon S, Raisman G, Li Y. Transplantation of Cultured Olfactory Bulb Cells Prevents Abnormal Sensory Responses During Recovery From Dorsal Root Avulsion in the Rat. Cell Transplant. 2017;26:913-924 pubmed publisher
    ..These regenerating axons, including Tuj1 and CGRP immunoreactive fibers, were ensheathed by the olfactory ensheathing cells...
  75. Yuan H, Lauritsen C, Kaiser E, Silberstein S. CGRP Monoclonal Antibodies for Migraine: Rationale and Progress. BioDrugs. 2017;31:487-501 pubmed publisher
    Calcitonin gene-related peptide (CGRP), a neuropeptide abundant in the trigeminal system and widely expressed in both the peripheral and central nervous systems, has recently emerged as a promising target for migraine management...
  76. Maayan C, Becker Y, Gesundheit B, Girgis S. Calcitonin gene related peptide in familial dysautonomia. Neuropeptides. 2001;35:189-95 pubmed
    Familial dysautonomia (FD) patients have diminished sensory C-fibers. Calcitonin gene related peptide (CGRP) is a widely distributed neuropeptide and prominent neurotransmitter in C-fibers...
  77. Sharma I, Dhawan V, Saha S, Rashmi B, Dhaliwal L. Implication of the RAGE-EN-RAGE axis in endometriosis. Int J Gynaecol Obstet. 2010;110:199-202 pubmed publisher
    ..001). Our findings strengthen the hypothesis of an underlying inflammation in the pathophysiology of endometriosis and suggest exploring anti-inflammatory therapies as adjunct treatment. ..
  78. Rungroj N, Sritippayawan S, Thongnoppakhun W, Paemanee A, Sawasdee N, Nettuwakul C, et al. Prothrombin haplotype associated with kidney stone disease in Northeastern Thai patients. Urology. 2011;77:249.e17-23 pubmed publisher
    ..67 single nucleotide polymorphisms (SNP) distributed within 8 candidate genes, namely TFF1, S100A8, S100A9, S100A12, AMBP, SPP1, UMOD, and F2, which encode stone inhibitor proteins, including trefoil factor 1, calgranulin (A, B, ..
  79. Kim J, Park S, Lee M, Song Y, Han S, Kim S, et al. Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis. Atherosclerosis. 2012;220:208-14 pubmed publisher
    ..0mm and/or plaque formation). Our findings suggest that elevated plasma EN-RAGE and decreased sRAGE level could play a crucial role in systemic inflammation and carotid atherosclerosis in PD patients. ..
  80. Chellan B, Yan L, Sontag T, Reardon C, HOFMANN BOWMAN M. IL-22 is induced by S100/calgranulin and impairs cholesterol efflux in macrophages by downregulating ABCG1. J Lipid Res. 2014;55:443-54 pubmed publisher
    S100A8/9 and S100A12 are emerging biomarkers for disease activity of autoimmune and cardiovascular diseases...
  81. Taylan A, Gurler O, Toprak B, Sisman A, Yalcin H, Colak A, et al. S1000A12, Chitotriosidase, and Resolvin D1 as Potential Biomarkers of Familial Mediterranean Fever. J Korean Med Sci. 2015;30:1241-5 pubmed publisher
    ..Serum levels of highly sensitive C-reactive protein, serum amiloid A (SAA), S100A12, chitotriosidase, and resolvin D1 were measured...
  82. Codreanu S, Hoeksema M, Slebos R, Zimmerman L, Rahman S, Li M, et al. Identification of Proteomic Features To Distinguish Benign Pulmonary Nodules from Lung Adenocarcinoma. J Proteome Res. 2017;16:3266-3276 pubmed publisher
    ..nodule-specific abundance of 10 proteins including ALOX5, ALOX5AP, CCL19, CILP1, COL5A2, ITGB2, ITGAX, PTPRE, S100A12, and SLC2A3 and significant ADC-specific abundance of CEACAM6, CRABP2, LAD1, PLOD2, and TMEM110-MUSTN1...
  83. Khan S, Olesen A, Ashina M. CGRP, a target for preventive therapy in migraine and cluster headache: Systematic review of clinical data. Cephalalgia. 2017;:333102417741297 pubmed publisher
    ..Targeting the calcitonin gene-related peptide (CGRP) pathway to treat these headaches may be the first focused therapeutic option to date, with the potential for ..
  84. Strauss G, Edvinsson L, Larsen F, Møller K, Knudsen G. Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure. Neuropeptides. 2001;35:174-80 pubmed
    The present study investigated the circulating levels and cerebral fluxes of calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), and neuropeptide Y (NPY) and their relation to cerebral blood flow (CBF) during ..
  85. Shiotsu Y, Mori Y, Nishimura M, Hatta T, Imada N, Maki N, et al. Prognostic utility of plasma S100A12 levels to establish a novel scoring system for predicting mortality in maintenance hemodialysis patients: a two-year prospective observational study in Japan. BMC Nephrol. 2013;14:16 pubmed publisher
    b>S100A12 protein is an endogenous receptor ligand for advanced glycation end products. In this study, the plasma S100A12 level was assessed as an independent predictor of mortality, and its utility in clinical settings was examined...
  86. Pradeep A, Martande S, Singh S, Suke D, Raju A, Naik S. Correlation of human S100A12 (EN-RAGE) and high-sensitivity C-reactive protein as gingival crevicular fluid and serum markers of inflammation in chronic periodontitis and type 2 diabetes. Inflamm Res. 2014;63:317-23 pubmed publisher
    The aim of the present study was to evaluate the levels and correlation of human S100A12 and high-sensitivity C-reactive protein (hs-CRP) in gingival crevicular fluid (GCF) and serum in chronic periodontitis (CP) subjects with and ..
  87. Hou F, Wang L, Wang H, Gu J, Li M, Zhang J, et al. Elevated gene expression of S100A12 is correlated with the predominant clinical inflammatory factors in patients with bacterial pneumonia. Mol Med Rep. 2015;11:4345-52 pubmed publisher
    ..The expression of the S100A12 gene was analyzed by reverse transcription quantitative polymerase chain reaction in samples obtained from 46 ..
  88. Choi B, Ro H, Jung E, Kim A, Chang J, Lee H, et al. Circulating S100A12 Levels Are Associated with Progression of Abdominal Aortic Calcification in Hemodialysis Patients. PLoS ONE. 2016;11:e0150145 pubmed publisher
    ..Recently, soluble receptor for advanced glycation end product (sRAGE) and extracellular RAGE binding protein S100A12 (EN-RAGE) have been reported to be involved in the process of vascular calcification...
  89. Martins L, Teixeira A, Domingues R. Neurotrophins and Migraine. Vitam Horm. 2017;104:459-473 pubmed publisher
    ..of trigeminal sensory afferent fibers leading to neuropeptides release such as calcitonin gene-related peptide (CGRP) and substance P (SP). This triggers an inflammatory cascade causing a neurogenic inflammation...
  90. Aikawa J, Uchida K, Takano S, Inoue G, Minatani A, Miyagi M, et al. Expression of calcitonin gene-related peptide in the infrapatellar fat pad in knee osteoarthritis patients. J Orthop Surg Res. 2017;12:65 pubmed publisher
    ..Calcitonin gene-related peptide (CGRP) is a vasodilatory neuropeptide that is localized to joint tissues and has recently been implicated in the ..
  91. Shinohara K, Watabe A, Nagase M, Okutsu Y, Takahashi Y, Kurihara H, et al. Essential role of endogenous calcitonin gene-related peptide in pain-associated plasticity in the central amygdala. Eur J Neurosci. 2017;46:2149-2160 pubmed publisher
    The role of the neuropeptide calcitonin gene-related peptide (CGRP) is well established in nociceptive behaviors...
  92. Nazari A, Khorramdelazad H, Hassanshahi G, Day A, Sardoo A, Fard E, et al. S100A12 in renal and cardiovascular diseases. Life Sci. 2017;191:253-258 pubmed publisher
    Expression of S100A12, a small calcium-binding protein, by neutrophils and monocytes/macrophages induces proinflammatory responses via ligation with the receptor for advanced glycation end-products (RAGE) and subsequent activation of ..