RXRalpha

Summary

Gene Symbol: RXRalpha
Description: retinoid X receptor alpha
Alias: NR2B1, retinoic acid receptor RXR-alpha, nuclear receptor subfamily 2 group B member 1, retinoid X nuclear receptor alpha
Species: human
Products:     RXRalpha

Top Publications

  1. Bourguet W, Vivat V, Wurtz J, Chambon P, Gronemeyer H, Moras D. Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains. Mol Cell. 2000;5:289-98 pubmed
    ..The unexpected presence of a fatty acid in the ligand-binding pocket of RXRalpha(F318A is likely to account for its apparent "constitutivity...
  2. Ahuja H, Szanto A, Nagy L, Davies P. The retinoid X receptor and its ligands: versatile regulators of metabolic function, cell differentiation and cell death. J Biol Regul Homeost Agents. 2003;17:29-45 pubmed
    ..RXRs function as master regulators producing diverse physiological effects through the activation of multiple nuclear receptor complexes. RXRs represent important targets for pharmacologic interventions and therapeutic applications. ..
  3. Buentig N, Stoerkel S, Richter E, Dallmann I, Reitz M, Atzpodien J. Predictive impact of retinoid X receptor-alpha-expression in renal-cell carcinoma. Cancer Biother Radiopharm. 2004;19:331-42 pubmed
    ..However, the exact mechanisms underlying the aberrant compartmentalization and the functions of RXR-alpha in RCC remain to be determined. ..
  4. Matsusue K, Miyoshi A, Yamano S, Gonzalez F. Ligand-activated PPARbeta efficiently represses the induction of LXR-dependent promoter activity through competition with RXR. Mol Cell Endocrinol. 2006;256:23-33 pubmed
    ..PPARbetaL405R, deficient in RXRalpha binding, had no effect on angptl3-Luc promoter activity...
  5. Bugge T, Pohl J, Lonnoy O, Stunnenberg H. RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J. 1992;11:1409-18 pubmed
    ..The identification of RXR alpha as a dimerization partner for the RARs, T3Rs and VD3R has important implications as to the function of these receptors and their ligands in development, homeostasis and neoplasia. ..
  6. Chen J, Evans R. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature. 1995;377:454-7 pubmed
    ..Together, our results identify a new class of cofactors which may be important mediators of hormone action. ..
  7. Perlmann T, Jansson L. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev. 1995;9:769-82 pubmed
    ..Because expression of both NGFI-B and NURR1 is rapidly induced by various growth factors, these findings also suggest a novel mechanism for convergence between vitamin A or retinoid and growth factor signaling pathways. ..
  8. Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, et al. Functional interaction between Oct-1 and retinoid X receptor. J Biol Chem. 1999;274:19103-8 pubmed
    ..These results suggest that Oct-1 functionally interacts with RXR and negatively regulates the nuclear receptor signaling pathway by altering the DNA binding ability of the receptors. ..
  9. Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, et al. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat Genet. 1999;23:287-95 pubmed
    ..Here we show that PML, Tif1alpha and RXRalpha/RARalpha function together in a transcription complex that is dependent on retinoic acid (RA)...

More Information

Publications227 found, 100 shown here

  1. Krogsdam A, Nielsen C, Neve S, Holst D, Helledie T, Thomsen B, et al. Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation. Biochem J. 2002;363:157-65 pubmed
    ..Our results suggest that the transactivation potential of liganded PPAR delta can be fine-tuned by interaction with NCoR and SMRT in a manner determined by the expression levels of corepressors and coactivators. ..
  2. Choi S, Chung S, Rho E, Lee H, Lee M, Choi H, et al. Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. J Biol Chem. 2006;281:30669-77 pubmed
    Retinoid X receptor alpha (RXRalpha) belongs to a family of ligand-activated transcription factors that regulate many aspects of metazoan life...
  3. Li G, Walch E, Yang X, Lippman S, Clifford J. Cloning and characterization of the human retinoid X receptor alpha gene: conservation of structure with the mouse homolog. Biochem Biophys Res Commun. 2000;269:54-7 pubmed
    ..The genes for three distinct retinoid X receptors, RXRalpha, beta, and gamma, have been localized to separate chromosomes...
  4. Gampe R, Montana V, Lambert M, Miller A, Bledsoe R, Milburn M, et al. Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol Cell. 2000;5:545-55 pubmed
    The nuclear receptor PPARgamma/RXRalpha heterodimer regulates glucose and lipid homeostasis and is the target for the antidiabetic drugs GI262570 and the thiazolidinediones (TZDs)...
  5. Nohara A, Kawashiri M, Claudel T, Mizuno M, Tsuchida M, Takata M, et al. High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia. Arterioscler Thromb Vasc Biol. 2007;27:923-8 pubmed
    ..01). In vitro, RXRgamma Ser14 showed significantly stronger repression of the lipoprotein lipase promoter than RXRgamma Gly14. These findings suggest that RXRgamma contributes to the genetic background of FCHL. ..
  6. Chandra V, Huang P, Hamuro Y, Raghuram S, Wang Y, Burris T, et al. Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature. 2008;456:350-6 pubmed publisher
    ..The PPAR-gamma LBD cooperates with both DNA-binding domains (DBDs) to enhance response-element binding. The A/B segments are highly dynamic, lacking folded substructures despite their gene-activation properties. ..
  7. Jacobs E, Martinez M, Campbell P, Conti D, Duggan D, Figueiredo J, et al. Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry. Carcinogenesis. 2010;31:1412-6 pubmed publisher
    ..29-0.96). These results provide support that RXRA SNPs rs7861779 and rs12004589 and CASR SNP rs1801726 may be important markers for colorectal neoplasia. Further work is needed to elucidate their role in the carcinogenic pathway. ..
  8. Rochel N, Ciesielski F, Godet J, Moman E, Roessle M, Peluso Iltis C, et al. Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings. Nat Struct Mol Biol. 2011;18:564-70 pubmed publisher
    ..The results reveal two additional features: the conserved position of the ligand-binding domains at the 5' ends of the target DNAs and the binding of only one coactivator molecule per heterodimer, to RXR's partner. ..
  9. Mouchon A, Delmotte M, Formstecher P, Lefebvre P. Allosteric regulation of the discriminative responsiveness of retinoic acid receptor to natural and synthetic ligands by retinoid X receptor and DNA. Mol Cell Biol. 1999;19:3073-85 pubmed
    ..activation properties which are reflected by their abilities to promote interaction of DNA-bound human RXRalpha (hRXRalpha)-hRARalpha heterodimers with the nuclear receptor coactivator (NCoA) SRC-1 in vitro...
  10. Xiao J, Ghosn C, Hinchman C, Forbes C, Wang J, Snider N, et al. Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway. J Biol Chem. 2003;278:29954-62 pubmed
    ..These results suggest a potential role for RXR and its agonists in the regulation of beta-catenin turnover and related biological events. ..
  11. Szanto A, Narkar V, Shen Q, Uray I, Davies P, Nagy L. Retinoid X receptors: X-ploring their (patho)physiological functions. Cell Death Differ. 2004;11 Suppl 2:S126-43 pubmed
    ..Finally, aspects of RXR's involvement in myeloid differentiation and apoptosis are summarized along with issues on RXR's suitability as a therapeutic target. ..
  12. Sinkkonen L, Malinen M, Saavalainen K, Väisänen S, Carlberg C. Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter. Nucleic Acids Res. 2005;33:2440-51 pubmed
  13. Ishaq M, Zhang Y, Natarajan V. Activation-induced down-regulation of retinoid receptor RXRalpha expression in human T lymphocytes. Role of cell cycle regulation. J Biol Chem. 1998;273:21210-6 pubmed
    ..Nucleotide sequence analysis identified the 5' end of this RNA as human retinoid receptor RXRalpha mRNA. Here, we report the nucleotide sequence of 3...
  14. Ishaq M, Fan M, Wigmore K, Gaddam A, Natarajan V. Regulation of retinoid X receptor responsive element-dependent transcription in T lymphocytes by Ser/Thr phosphatases: functional divergence of protein kinase C (PKC)theta; and PKC alpha in mediating calcineurin-induced transactivation. J Immunol. 2002;169:732-8 pubmed
    ..Thus, PKC theta; and PKC alpha may function as positive and negative modulators, respectively, of CN-regulated RXRE-dependent transcription during T cell activation. ..
  15. Bildirici I, Roh C, Schaiff W, Lewkowski B, Nelson D, Sadovsky Y. The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X receptor. J Clin Endocrinol Metab. 2003;88:6056-62 pubmed
    ..We conclude that the expression of adipophilin is enhanced during trophoblast differentiation and is up-regulated by ligand-activated PPARgamma/RXR. Enhanced adipophilin expression may contribute to fatty acid uptake by the placenta. ..
  16. Feng J, Chen J, Yan J, Jones I, Craddock N, Cook E, et al. Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. Am J Med Genet B Neuropsychiatr Genet. 2005;133B:50-3 pubmed
    ..One uncommon missense variant was found in each of the RARbeta, RARgamma, and RXRgamma genes. We conclude that structural variants in the RAR/RXR and NURR1 genes do not play a major role in the etiology of schizophrenia. ..
  17. Abu Amero K, Helwa I, Al Muammar A, Strickland S, Hauser M, Allingham R, et al. Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population. J Negat Results Biomed. 2015;14:10 pubmed publisher
    ..This report aims at supporting the possible association between CCT-associated SNPs and KC susceptibility. ..
  18. Folkers G, van der Saag P. Adenovirus E1A functions as a cofactor for retinoic acid receptor beta (RAR beta) through direct interaction with RAR beta. Mol Cell Biol. 1995;15:5868-78 pubmed
    ..We propose that E1A functions as a cofactor by interacting with both TBP and RAR, thereby stabilizing the preinitiation complex. ..
  19. Farboud B, Hauksdottir H, Wu Y, Privalsky M. Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression. Mol Cell Biol. 2003;23:2844-58 pubmed
    ..We refer to this phenomenon as a "gate-latch" model of corepressor regulation. ..
  20. Ovsyannikova I, Dhiman N, Haralambieva I, Vierkant R, O Byrne M, Jacobson R, et al. Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. Hum Genet. 2010;127:207-21 pubmed publisher
    ..This is the first paper to present evidence that polymorphisms in the TLR, vitamin A, vitamin D receptor, and innate immunity genes can influence adaptive cytokine responses to rubella vaccination. ..
  21. McKinney B, Lareau C, Oberg A, Kennedy R, Ovsyannikova I, Poland G. The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine. PLoS ONE. 2016;11:e0158016 pubmed publisher
    ..The integrative analysis spotlights the role of genes related to retinoid X receptor alpha (RXRA), which has been implicated in a previous epistasis network analysis of smallpox vaccine. ..
  22. O Brien K, Sandler D, Kinyamu H, Taylor J, Weinberg C. Single-Nucleotide Polymorphisms in Vitamin D-Related Genes May Modify Vitamin D-Breast Cancer Associations. Cancer Epidemiol Biomarkers Prev. 2017;26:1761-1771 pubmed publisher
    ..b>Impact: This work strengthens the evidence for protective effects of vitamin D. Cancer Epidemiol Biomarkers Prev; 26(12); 1761-71. ©2017 AACR. ..
  23. Ray D, Spinelli S, Pollock S, Murant T, O Brien J, Blumberg N, et al. Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles. Thromb Haemost. 2008;99:86-95 pubmed publisher
  24. Adlakha Y, Khanna S, Singh R, Singh V, Agrawal A, Saini N. Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXR? expression and cholesterol homeostasis. Cell Death Dis. 2013;4:e780 pubmed publisher
    ..In this study, we provide the first evidence of miR-128-2 to be a new regulator of cholesterol homeostasis. Our study shows dual role of miR-128-2, as a pro-apoptotic molecule as well as a regulator of cholesterol homeostasis...
  25. Qiu J, Zeisig B, Li S, Liu W, Chu H, Song Y, et al. Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia. Leukemia. 2015;29:1153-62 pubmed publisher
    ..Together, these results indicate that deregulation of the retinoid/rexinoid signaling pathway has a major role and may represent a potential therapeutic target for NUP98-RARG-mediated transformation. ..
  26. Wang A, Avramopoulos D, Lori A, MULLE J, Conneely K, Powers A, et al. Genome-wide association study in two populations to determine genetic variants associated with Toxoplasma gondii infection and relationship to schizophrenia risk. Prog Neuropsychopharmacol Biol Psychiatry. 2019;92:133-147 pubmed publisher
    ..These data provide new insights into the pathophysiology of this common neurotropic parasite. ..
  27. Heyman R, Mangelsdorf D, Dyck J, Stein R, Eichele G, Evans R, et al. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell. 1992;68:397-406 pubmed
    ..The discovery of this novel hormone points to the key role retinoid metabolism may have in generating new signaling pathways. ..
  28. Lee J, Ryan F, Swaffield J, Johnston S, Moore D. Interaction of thyroid-hormone receptor with a conserved transcriptional mediator. Nature. 1995;374:91-4 pubmed
    ..Here we show that Trip1 can functionally substitute for Sug1 in yeast, and that both proteins interact in vitro with the thyroid-hormone receptor, and with the transcriptional activation domains of yeast GAL4 and of herpes virus VP16. ..
  29. Ogawa H, Komatsu T, Hiraoka Y, Morohashi K. Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated nuclear receptor Ad4BP/SF-1. Mol Biol Cell. 2009;20:4235-45 pubmed publisher
    ..These findings suggest that ARIP4 may be a cofactor that modulates SUMO-mediated fine-tuning of transcriptional suppression. ..
  30. Karami S, Brennan P, Rosenberg P, Navratilova M, Mates D, Zaridze D, et al. Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk. PLoS ONE. 2009;4:e7013 pubmed publisher
    ..This study comprehensively evaluated genetic variation across eight vitamin D pathway genes in relation to RCC risk. We found increased risk associated with VDR and RXRA. Replication studies are warranted to confirm these findings. ..
  31. Garcia Bates T, Baglole C, Bernard M, Murant T, Simpson Haidaris P, Phipps R. Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation. J Immunol. 2009;183:6903-12 pubmed publisher
    ..Herein, we examined the role of the peroxisome proliferator-activated receptor (PPAR)gamma/RXRalpha pathway on human B cell differentiation...
  32. Chesney R, Han X. Differential regulation of TauT by calcitriol and retinoic acid via VDR/RXR in LLC-PK1 and MCF-7 cells. Adv Exp Med Biol. 2013;776:291-305 pubmed publisher
    ..Our results show that expression of TauT is differentially regulated by VD(3) and RA via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner. ..
  33. Mangelsdorf D, Umesono K, Kliewer S, Borgmeyer U, Ong E, Evans R. A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. Cell. 1991;66:555-61 pubmed
    ..The discovery of this new RX response element provides a means for distinguishing between the two retinoid receptor systems and suggests that an RXR-mediated pathway exists for modulating vitamin A metabolism. ..
  34. Andreotti G, Menashe I, Chen J, Chang S, Rashid A, Gao Y, et al. Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China. Eur J Epidemiol. 2009;24:763-74 pubmed publisher
    ..These findings provide insight into the role of lipid metabolism genes, as well as the mechanisms by which these genes may be linked with disease. ..
  35. Giardina C, Nakanishi M, Khan A, Kuratnik A, Xu W, Brenner B, et al. Regulation of VDR Expression in Apc-Mutant Mice, Human Colon Cancers and Adenomas. Cancer Prev Res (Phila). 2015;8:387-99 pubmed publisher
    ..Determining the mechanisms of VDR regulation in colon neoplasms may significantly enhance our ability to use vitamin D as a cancer prevention agent. ..
  36. Lee W, Jena S, Rodríguez E, O Donovan S, Wagner C, Jurutka P, et al. Distinct functional modes of SUMOylation for retinoid X receptor alpha. Biochem Biophys Res Commun. 2015;464:195-200 pubmed publisher
    ..Our findings highlight combinatorial effects of SUMOylation may regulate RXRα-directed signalling in a gene-specific fashion. ..
  37. Qiu J, Lu X, Zeisig B, Ma Z, Cai X, Chen S, et al. Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}. Blood. 2010;115:643-52 pubmed publisher
    ..was able to bind to a panel of retinoic acid response elements both as a homodimer and as a heterodimer with RXRalpha, and demonstrated distinct DNA-binding characteristics compared with wild-type RARalpha/RXRalpha or other X-..
  38. Janakiram N, Mohammed A, Zhang Y, Brewer M, Bryant T, Lightfoot S, et al. Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats. Cancer Prev Res (Phila). 2013;6:1251-61 pubmed publisher
    ..The combination of low doses of raloxifene and bexarotene significantly suppressed the progression of colonic adenomas to adenocarcinomas and may be useful for colon cancer prevention and/or treatment in high-risk individuals. ..
  39. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 1996;85:403-14 pubmed
  40. Huang N, vom Baur E, Garnier J, Lerouge T, Vonesch J, Lutz Y, et al. Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators. EMBO J. 1998;17:3398-412 pubmed
    ..Interestingly, NSD1 contains separate repression and activation domains. Thus, NSD1 may define a novel class of bifunctional transcriptional intermediary factors playing distinct roles in both the presence and absence of ligand. ..
  41. Burrage P, Schmucker A, Ren Y, Sporn M, Brinckerhoff C. Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression. Arthritis Res Ther. 2008;10:R139 pubmed publisher
    ..We conclude that the efficacy of combined treatment with lower doses of each drug may minimize potential side effects of treatment with these compounds. ..
  42. White D, Takeda T, DeGroot L, Stefansson K, Arnason B. Beta-trace gene expression is regulated by a core promoter and a distal thyroid hormone response element. J Biol Chem. 1997;272:14387-93 pubmed
    ..We have shown that a gene active in the choroid plexus and meninges is responsive to T3. T3 may play a role in the regulated transport of substances into the cerebrospinal fluid and ultimately the brain. ..
  43. Boudjelal M, Voorhees J, Fisher G. Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells. Exp Cell Res. 2002;274:130-7 pubmed
    ..Treatment of HaCaT cells with all-trans-retinoic acid or 9-cis-retinoic acid reduced RARgamma and RXRalpha protein levels by one-half within 24 h...
  44. Flajollet S, Lefebvre B, Cudejko C, Staels B, Lefebvre P. The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor. Mol Cell Endocrinol. 2007;270:23-32 pubmed
    ..This coactivating property is dependent on SRC1 expression, showing that HATs and SWI/SNF cooperate in this retinoid-controlled transcriptional process. ..
  45. Han S, Li T, Ellis E, Strom S, Chiang J. A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. Mol Endocrinol. 2010;24:1151-64 pubmed publisher
    ..nuclear receptor corepressor-1 and silencing mediator of retinoid and thyroid with VDR/retinoid X receptor-alpha (RXRalpha)...
  46. Berrodin T, Marks M, Ozato K, Linney E, Lazar M. Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. Mol Endocrinol. 1992;6:1468-78 pubmed
  47. Yasumo H, Masuda N, Furusawa T, Tsukamoto T, Sadano H, Osumi T. Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors. Biochim Biophys Acta. 2000;1490:189-97 pubmed
    ..NRBF-2 exhibited a gene activation function, when tethered to a heterologous DNA binding domain, in both mammalian cells and yeast. ..
  48. Andersson E, Rosdahl I, Torma H, Vahlquist A. Differential effects of UV irradiation on nuclear retinoid receptor levels in cultured keratinocytes and melanocytes. Exp Dermatol. 2003;12:563-71 pubmed
    ..UV irradiation on the expression of the predominant retinoid receptors in the human skin (RARalpha, RARgamma and RXRalpha) and the AP-1 protein c-Jun; mRNA levels were studied by real-time PCR and protein levels by Western blot...
  49. Lengqvist J, Mata de Urquiza A, Bergman A, Willson T, Sjövall J, Perlmann T, et al. Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain. Mol Cell Proteomics. 2004;3:692-703 pubmed
    ..In additional experiments, the binding of fatty acid ligands to RXRalpha is directly demonstrated by electrospray mass spectrometry of the noncovalent complex between the RXR ligand-..
  50. Shi H, Yu X, Li Q, Ye X, Gao Y, Ma J, et al. Association between PPAR-? and RXR-? gene polymorphism and metabolic syndrome risk: a case-control study of a Chinese Han population. Arch Med Res. 2012;43:233-42 pubmed publisher
    ..0107). The present study suggested that the variant genotypes in PPAR-? gene could increase the risk of MetS; however, genotypes in RXR-? gene could decrease the risk of MetS in a Chinese Han population. ..
  51. Lou X, Toresson G, Benod C, Suh J, Philips K, Webb P, et al. Structure of the retinoid X receptor ?-liver X receptor ? (RXR?-LXR?) heterodimer on DNA. Nat Struct Mol Biol. 2014;21:277-81 pubmed publisher
    ..Comparisons of RXR?-LXR?s in the crystal asymmetric unit and with previous NR structures reveal flexibility in NR organization and suggest a role for RXR? in adaptation of heterodimeric complexes to DNA. ..
  52. Jeyakumar M, Tanen M, Bagchi M. Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor. Mol Endocrinol. 1997;11:755-67 pubmed
    ..Our results raise the interesting possibility that a RXR-specific ligand may modulate T3-mediated signaling by inducing additional interactions between TRE-bound TR-RXR heterodimer and the coactivator. ..
  53. Kliewer S, Moore J, Wade L, Staudinger J, Watson M, Jones S, et al. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell. 1998;92:73-82 pubmed
    ..Our results provide evidence for the existence of a novel steroid hormone signaling pathway with potential implications in the regulation of steroid hormone and sterol homeostasis. ..
  54. Scorrano L, Petronilli V, Di Lisa F, Bernardi P. Commitment to apoptosis by GD3 ganglioside depends on opening of the mitochondrial permeability transition pore. J Biol Chem. 1999;274:22581-5 pubmed
    ..These results provide compelling evidence that opening of the permeability transition pore is causally related to apoptosis. ..
  55. Liu Z, Zhou G, Nakamura M, Bai Y, Li Y, Ozaki T, et al. Retinoid X receptor ? up-regulation is correlated with dedifferentiation of tumor cells and lymph node metastasis in papillary thyroid carcinoma. Pathol Int. 2011;61:109-15 pubmed publisher
    ..545; 95% confidence interval: 1.575-27.208) of LNM using multivariate analysis. These results suggest that RXR? may play a role in the dedifferentiation and metastasis of PTC. ..
  56. Na S, Kim H, Lee S, Choi H, Na D, Lee M, et al. IkappaBbeta interacts with the retinoid X receptor and inhibits retinoid-dependent transactivation in lipopolysaccharide-treated cells. J Biol Chem. 1998;273:3212-5 pubmed
    ..These results suggest a novel IkappaBbeta-mediated antagonism between the signaling pathways of NFkappaB and RXR. ..
  57. Ishii H, Tezuka T, Ishikawa H, Takada K, Oida K, Horie S. Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the T. Blood. 2003;101:4765-74 pubmed
    ..in the TM promoter were significantly reduced with decreased expression of RARbeta, retinoid X receptor alpha (RXRalpha), Sp1, and Sp3 in the nuclei...
  58. Seuter S, Väisänen S, Radmark O, Carlberg C, Steinhilber D. Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene. Biochim Biophys Acta. 2007;1771:864-72 pubmed
    ..This indicates DNA looping of the TSS to even very distant gene regions. In summary, we suggest that the upregulation of the primary 1alpha,25(OH)(2)D(3) target 5-LO is mediated in vivo by a prominent VDRE in intron 4. ..
  59. Carvallo L, Henriquez B, Paredes R, Olate J, Onate S, Van Wijnen A, et al. 1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex. J Cell Physiol. 2008;214:740-9 pubmed
    ..Together, our results support a model where VDR preferentially recruits SRC-1 to enhance bone-specific OC gene transcription. ..
  60. Wang F, Soprano K, Soprano D. Role of Acinus in regulating retinoic acid-responsive gene pre-mRNA splicing. J Cell Physiol. 2015;230:791-801 pubmed publisher
    ..Taken together, these studies demonstrate that Acinus functions in both RAR-dependent splicing and RAR-dependent transcription. ..
  61. Xia Y, Cheng X, Li Y, Valdez K, Chen W, Liang T. Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype. J Virol. 2018;92: pubmed publisher
    ..This may coincidently induce a premalignant phenotype that predisposes infected hepatocytes to subsequent malignant transformation. ..
  62. Heinlein C, Ting H, Yeh S, Chang C. Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma. J Biol Chem. 1999;274:16147-52 pubmed
    ..Finally, we show that AR can squelch PPARgamma-ARA70 transactivation, which suggests that cross-talk may occur between PPARgamma- and AR-mediated responses in adipocytes. ..
  63. Rachez C, Gamble M, Chang C, Atkins G, Lazar M, Freedman L. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. Mol Cell Biol. 2000;20:2718-26 pubmed
    ..The results demonstrate that different coactivator complexes with distinct functions bind to the same transactivation region of nuclear receptors, suggesting that they are both required for transcription activation by nuclear receptors. ..
  64. Lattuada D, Vigano P, Mangioni S, Sassone J, Di Francesco S, Vignali M, et al. Accumulation of retinoid X receptor-alpha in uterine leiomyomas is associated with a delayed ligand-dependent proteasome-mediated degradation and an alteration of its transcriptional activity. Mol Endocrinol. 2007;21:602-12 pubmed
    ..The present study was based on the demonstration of an accumulation of full-length retinoid X receptor alpha (RXRalpha) in leiomyomas that was not associated with a modification of its gene expression...
  65. Clendenen T, Ge W, Koenig K, Axelsson T, Liu M, Afanasyeva Y, et al. Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study. PLoS ONE. 2015;10:e0140478 pubmed publisher
    ..These results, combined with the observation in this cohort and most other prospective studies of no association of circulating 25(OH)D with breast cancer risk, do not support an association between vitamin D and breast cancer risk. ..
  66. Yuan C, Ito M, Fondell J, Fu Z, Roeder R. The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci U S A. 1998;95:7939-44 pubmed
  67. Lima L, Almeida S, Hutz M, Fiegenbaum M. PPARA, RXRA, NR1I2 and NR1I3 gene polymorphisms and lipid and lipoprotein levels in a Southern Brazilian population. Mol Biol Rep. 2013;40:1241-7 pubmed publisher
    ..009). Our results suggest that polymorphisms in the RXRA and NR1I3 genes influence lipid profile in a Southern Brazilian population. However, these general and gender association require confirmation in subsequent studies. ..
  68. Svensson D, Nebel D, Voss U, Ekblad E, Nilsson B. Vitamin D-induced up-regulation of human keratinocyte cathelicidin anti-microbial peptide expression involves retinoid X receptor ?. Cell Tissue Res. 2016;366:353-362 pubmed publisher
    ..We conclude that the 1,25D3-evoked stimulation of CAMP expression in human skin keratinocytes is dependent on RXR? but is not associated with the up-regulation of VDR expression. ..
  69. Lee S, Choi H, Song M, Lee M, Lee J. Estrogen receptor, a common interaction partner for a subset of nuclear receptors. Mol Endocrinol. 1998;12:1184-92 pubmed
    ..From these results, we propose that ER is a common interaction partner for a subset of receptors, and these interactions should mediate novel signaling pathways in vivo. ..
  70. Lee S, Anzick S, Choi J, Bubendorf L, Guan X, Jung Y, et al. A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. J Biol Chem. 1999;274:34283-93 pubmed
    ..From these results, we concluded that ASC-2 is a bona fide transcription coactivator molecule of nuclear receptors, and its altered expression may contribute to the development of cancers. ..
  71. Zhang C, Baudino T, Dowd D, Tokumaru H, Wang W, MacDonald P. Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription. J Biol Chem. 2001;276:40614-20 pubmed
  72. Franco P, Li G, Wei L. Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase. Mol Cell Endocrinol. 2003;206:1-12 pubmed
    ..Both the N- and C-terminal portions of HDAC3 showed interaction with the TR2 DBD. Thus, multiple domains of HDAC3 form the interaction surface for the DBD of nuclear receptors. ..
  73. Surapureddi S, Viswakarma N, Yu S, Guo D, Rao M, Reddy J. PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex. Biochem Biophys Res Commun. 2006;343:535-43 pubmed
    ..We conclude that ciprofibrate, a PPARalpha ligand, binds a multiprotein complex and PRIC320 cloned from this complex functions as a nuclear receptor coactivator. ..
  74. Yan X, Pérez E, Leid M, Schimerlik M, de Lera A, Deinzer M. Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRalpha LBD. Protein Sci. 2007;16:2491-501 pubmed
  75. Si J, Collins S. IL-3-induced enhancement of retinoic acid receptor activity is mediated through Stat5, which physically associates with retinoic acid receptors in an IL-3-dependent manner. Blood. 2002;100:4401-9 pubmed
    ..Cytokine-mediated physical and functional interactions between Stat5 and RARs may play critical roles in regulating different stages of hematopoiesis. ..
  76. Chen W, Cai S, Xu S, Denson L, Soroka C, Boyer J. Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1221-7 pubmed
    ..MRP3 promoter, we have now identified nuclear receptor retinoic X receptor-alpha:retinoic acid receptor-alpha (RXRalpha:RARalpha) as a repressor of MRP3 activation by transcription factor Sp1...
  77. Fujishima F, Suzuki T, Nakamura Y, Taniyama Y, Ono K, Sugawara A, et al. Retinoid receptors in human esophageal squamous cell carcinoma: retinoid X receptor as a potent prognostic factor. Pathol Int. 2011;61:401-8 pubmed publisher
    ..0187). These findings all indicate the important roles of retinoid receptors, especially, RXR in the esophageal squamous cell carcinoma. ..
  78. Ma F, Liu S, Razani B, Arora N, Li B, Kagechika H, et al. Retinoid X receptor ? attenuates host antiviral response by suppressing type I interferon. Nat Commun. 2014;5:5494 pubmed publisher
  79. Tombolan L, Zampini M, Casara S, Boldrin E, Zin A, Bisogno G, et al. MicroRNA-27a Contributes to Rhabdomyosarcoma Cell Proliferation by Suppressing RARA and RXRA. PLoS ONE. 2015;10:e0125171 pubmed publisher
  80. Shahabi P, Lamothe F, Dumas S, Rouleau Mailloux É, Feroz Zada Y, Provost S, et al. Nuclear receptor gene polymorphisms and warfarin dose requirements in the Quebec Warfarin Cohort. Pharmacogenomics J. 2018;: pubmed publisher
    ..0026). Variants in the VDR gene were associated with the variability in response to warfarin, emphasizing the possible clinical relevance of nuclear receptor gene variants on the inter-individual variability in drug metabolism. ..
  81. Alfaro J, Fraile B, Lobo M, Royuela M, Paniagua R, Arenas M. Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate. J Androl. 2003;24:113-9 pubmed
    ..b>RXRalpha and RXRgamma were immunodetected in all samples of normal, nodular, and basal cell hyperplasia, as well as ..
  82. Yamamoto H, Shevde N, Warrier A, Plum L, DeLuca H, Pike J. 2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts. J Biol Chem. 2003;278:31756-65 pubmed
  83. Kim S, Shevde N, Pike J. 1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts. J Bone Miner Res. 2005;20:305-17 pubmed
    ..Selective use of co-regulators by target genes, however, may provide a mechanism for the unique and perhaps gene-selective responses observed with synthetic analogs such as ZK159222. ..
  84. Kojetin D, Matta Camacho E, Hughes T, Srinivasan S, Nwachukwu J, Cavett V, et al. Structural mechanism for signal transduction in RXR nuclear receptor heterodimers. Nat Commun. 2015;6:8013 pubmed publisher
    ..These findings define rules guiding how NRs integrate two ligand-dependent signalling pathways into RXR heterodimer-specific responses. ..
  85. Churchman M, Mullighan C. Ikaros: Exploiting and targeting the hematopoietic stem cell niche in B-progenitor acute lymphoblastic leukemia. Exp Hematol. 2017;46:1-8 pubmed publisher
  86. Rong S, Ma S, Yu X, Ma L, Chu W, Chan T, et al. Genetic associations for keratoconus: a systematic review and meta-analysis. Sci Rep. 2017;7:4620 pubmed publisher
    ..We also found SNPs in 10 genes/loci that had a summary P value < 0.05. Sensitivity analysis indicated that the results were robust. Replication studies and understanding the roles of these genes in keratoconus are warranted. ..
  87. Korpal M, Puyang X, Jeremy Wu Z, Seiler R, Furman C, Oo H, et al. Evasion of immunosurveillance by genomic alterations of PPAR?/RXR? in bladder cancer. Nat Commun. 2017;8:103 pubmed publisher
    ..Here the authors characterize diverse genetic alterations in MIBC that convergently lead to constitutive activation of PPARgamma/RXRalpha and result in immunosurveillance escape by inhibiting CD8+ T-cell recruitment.
  88. Na S, Kang B, Chung S, Han S, Ma X, Trinchieri G, et al. Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB. J Biol Chem. 1999;274:7674-80 pubmed
  89. Goodwin B, Hodgson E, D Costa D, Robertson G, Liddle C. Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Mol Pharmacol. 2002;62:359-65 pubmed
    ..Importantly, the human CAR response elements also mediate trans-activation of CYP3A4 by the human pregnane X receptor, suggesting that interplay between these receptors is likely to be an important determinant of CYP3A4 expression. ..