RXRalpha

Summary

Gene Symbol: RXRalpha
Description: retinoid X receptor alpha
Alias: NR2B1, retinoic acid receptor RXR-alpha, nuclear receptor subfamily 2 group B member 1, retinoid X nuclear receptor alpha
Species: human
Products:     RXRalpha

Top Publications

  1. Bourguet W, Vivat V, Wurtz J, Chambon P, Gronemeyer H, Moras D. Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains. Mol Cell. 2000;5:289-98 pubmed
    ..The unexpected presence of a fatty acid in the ligand-binding pocket of RXRalpha(F318A is likely to account for its apparent "constitutivity...
  2. Ahuja H, Szanto A, Nagy L, Davies P. The retinoid X receptor and its ligands: versatile regulators of metabolic function, cell differentiation and cell death. J Biol Regul Homeost Agents. 2003;17:29-45 pubmed
    ..RXRs function as master regulators producing diverse physiological effects through the activation of multiple nuclear receptor complexes. RXRs represent important targets for pharmacologic interventions and therapeutic applications. ..
  3. Buentig N, Stoerkel S, Richter E, Dallmann I, Reitz M, Atzpodien J. Predictive impact of retinoid X receptor-alpha-expression in renal-cell carcinoma. Cancer Biother Radiopharm. 2004;19:331-42 pubmed
    ..However, the exact mechanisms underlying the aberrant compartmentalization and the functions of RXR-alpha in RCC remain to be determined. ..
  4. Matsusue K, Miyoshi A, Yamano S, Gonzalez F. Ligand-activated PPARbeta efficiently represses the induction of LXR-dependent promoter activity through competition with RXR. Mol Cell Endocrinol. 2006;256:23-33 pubmed
    ..PPARbetaL405R, deficient in RXRalpha binding, had no effect on angptl3-Luc promoter activity...
  5. Bugge T, Pohl J, Lonnoy O, Stunnenberg H. RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J. 1992;11:1409-18 pubmed
    ..The identification of RXR alpha as a dimerization partner for the RARs, T3Rs and VD3R has important implications as to the function of these receptors and their ligands in development, homeostasis and neoplasia. ..
  6. Chen J, Evans R. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature. 1995;377:454-7 pubmed
    ..Together, our results identify a new class of cofactors which may be important mediators of hormone action. ..
  7. Perlmann T, Jansson L. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev. 1995;9:769-82 pubmed
    ..Because expression of both NGFI-B and NURR1 is rapidly induced by various growth factors, these findings also suggest a novel mechanism for convergence between vitamin A or retinoid and growth factor signaling pathways. ..
  8. Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, et al. Functional interaction between Oct-1 and retinoid X receptor. J Biol Chem. 1999;274:19103-8 pubmed
    ..These results suggest that Oct-1 functionally interacts with RXR and negatively regulates the nuclear receptor signaling pathway by altering the DNA binding ability of the receptors. ..
  9. Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, et al. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat Genet. 1999;23:287-95 pubmed
    ..Here we show that PML, Tif1alpha and RXRalpha/RARalpha function together in a transcription complex that is dependent on retinoic acid (RA)...

More Information

Publications264 found, 100 shown here

  1. Krogsdam A, Nielsen C, Neve S, Holst D, Helledie T, Thomsen B, et al. Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation. Biochem J. 2002;363:157-65 pubmed
    ..Our results suggest that the transactivation potential of liganded PPAR delta can be fine-tuned by interaction with NCoR and SMRT in a manner determined by the expression levels of corepressors and coactivators. ..
  2. Choi S, Chung S, Rho E, Lee H, Lee M, Choi H, et al. Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. J Biol Chem. 2006;281:30669-77 pubmed
    Retinoid X receptor alpha (RXRalpha) belongs to a family of ligand-activated transcription factors that regulate many aspects of metazoan life...
  3. Li G, Walch E, Yang X, Lippman S, Clifford J. Cloning and characterization of the human retinoid X receptor alpha gene: conservation of structure with the mouse homolog. Biochem Biophys Res Commun. 2000;269:54-7 pubmed
    ..The genes for three distinct retinoid X receptors, RXRalpha, beta, and gamma, have been localized to separate chromosomes...
  4. Gampe R, Montana V, Lambert M, Miller A, Bledsoe R, Milburn M, et al. Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol Cell. 2000;5:545-55 pubmed
    The nuclear receptor PPARgamma/RXRalpha heterodimer regulates glucose and lipid homeostasis and is the target for the antidiabetic drugs GI262570 and the thiazolidinediones (TZDs)...
  5. Nohara A, Kawashiri M, Claudel T, Mizuno M, Tsuchida M, Takata M, et al. High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia. Arterioscler Thromb Vasc Biol. 2007;27:923-8 pubmed
    ..01). In vitro, RXRgamma Ser14 showed significantly stronger repression of the lipoprotein lipase promoter than RXRgamma Gly14. These findings suggest that RXRgamma contributes to the genetic background of FCHL. ..
  6. Chandra V, Huang P, Hamuro Y, Raghuram S, Wang Y, Burris T, et al. Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature. 2008;456:350-6 pubmed publisher
    ..The PPAR-gamma LBD cooperates with both DNA-binding domains (DBDs) to enhance response-element binding. The A/B segments are highly dynamic, lacking folded substructures despite their gene-activation properties. ..
  7. Jacobs E, Martinez M, Campbell P, Conti D, Duggan D, Figueiredo J, et al. Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry. Carcinogenesis. 2010;31:1412-6 pubmed publisher
    ..29-0.96). These results provide support that RXRA SNPs rs7861779 and rs12004589 and CASR SNP rs1801726 may be important markers for colorectal neoplasia. Further work is needed to elucidate their role in the carcinogenic pathway. ..
  8. Rochel N, Ciesielski F, Godet J, Moman E, Roessle M, Peluso Iltis C, et al. Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings. Nat Struct Mol Biol. 2011;18:564-70 pubmed publisher
    ..The results reveal two additional features: the conserved position of the ligand-binding domains at the 5' ends of the target DNAs and the binding of only one coactivator molecule per heterodimer, to RXR's partner. ..
  9. Mouchon A, Delmotte M, Formstecher P, Lefebvre P. Allosteric regulation of the discriminative responsiveness of retinoic acid receptor to natural and synthetic ligands by retinoid X receptor and DNA. Mol Cell Biol. 1999;19:3073-85 pubmed
    ..activation properties which are reflected by their abilities to promote interaction of DNA-bound human RXRalpha (hRXRalpha)-hRARalpha heterodimers with the nuclear receptor coactivator (NCoA) SRC-1 in vitro...
  10. Xiao J, Ghosn C, Hinchman C, Forbes C, Wang J, Snider N, et al. Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway. J Biol Chem. 2003;278:29954-62 pubmed
    ..These results suggest a potential role for RXR and its agonists in the regulation of beta-catenin turnover and related biological events. ..
  11. Szanto A, Narkar V, Shen Q, Uray I, Davies P, Nagy L. Retinoid X receptors: X-ploring their (patho)physiological functions. Cell Death Differ. 2004;11 Suppl 2:S126-43 pubmed
    ..Finally, aspects of RXR's involvement in myeloid differentiation and apoptosis are summarized along with issues on RXR's suitability as a therapeutic target. ..
  12. Sinkkonen L, Malinen M, Saavalainen K, Väisänen S, Carlberg C. Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter. Nucleic Acids Res. 2005;33:2440-51 pubmed
  13. Ishaq M, Zhang Y, Natarajan V. Activation-induced down-regulation of retinoid receptor RXRalpha expression in human T lymphocytes. Role of cell cycle regulation. J Biol Chem. 1998;273:21210-6 pubmed
    ..Nucleotide sequence analysis identified the 5' end of this RNA as human retinoid receptor RXRalpha mRNA. Here, we report the nucleotide sequence of 3...
  14. Ishaq M, Fan M, Wigmore K, Gaddam A, Natarajan V. Regulation of retinoid X receptor responsive element-dependent transcription in T lymphocytes by Ser/Thr phosphatases: functional divergence of protein kinase C (PKC)theta; and PKC alpha in mediating calcineurin-induced transactivation. J Immunol. 2002;169:732-8 pubmed
    ..Thus, PKC theta; and PKC alpha may function as positive and negative modulators, respectively, of CN-regulated RXRE-dependent transcription during T cell activation. ..
  15. Forman B, Umesono K, Chen J, Evans R. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell. 1995;81:541-50 pubmed
    ..These findings suggest that allosteric interactions among heterodimers create complexes with unique properties. We suggest that allostery is a critical feature underlying the generation of diversity in hormone response networks. ..
  16. Natrajan M, de la Fuente A, Crawford A, Linehan E, Nuñez V, Johnson K, et al. Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain. 2015;138:3581-97 pubmed publisher
    ..These results reveal the retinoid X receptor pathway as a positive regulator of myelin debris clearance and a key player in the age-related decline in remyelination that may be targeted by available or newly-developed therapeutics. ..
  17. Préfontaine G, Walther R, Giffin W, Lemieux M, Pope L, Hache R. Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. J Biol Chem. 1999;274:26713-9 pubmed
  18. Iliopoulos D, Rotem A, Struhl K. Inhibition of miR-193a expression by Max and RXR? activates K-Ras and PLAU to mediate distinct aspects of cellular transformation. Cancer Res. 2011;71:5144-53 pubmed publisher
  19. Jolliffe D, Walton R, Griffiths C, Martineau A. Single nucleotide polymorphisms in the vitamin D pathway associating with circulating concentrations of vitamin D metabolites and non-skeletal health outcomes: Review of genetic association studies. J Steroid Biochem Mol Biol. 2016;164:18-29 pubmed publisher
  20. Van Every M, Dancik G, Paramesh V, Gurda G, Meier D, Cash S, et al. Genomic case report of a low grade bladder tumor metastasis to lung. BMC Urol. 2018;18:74 pubmed publisher
    ..We further validated that the patient might benefit from mTOR inhibition as a potential salvage therapy in an adjuvant or recurrent disease setting. ..
  21. Froeschlé A, Alric S, Kitzmann M, Carnac G, Aurade F, Rochette Egly C, et al. Retinoic acid receptors and muscle b-HLH proteins: partners in retinoid-induced myogenesis. Oncogene. 1998;16:3369-78 pubmed
    ..In conclusion, these results highlight novel interactions between two distinct groups of regulatory proteins that influence cell growth and differentiation. ..
  22. Pascussi J, Drocourt L, Fabre J, Maurel P, Vilarem M. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol Pharmacol. 2000;58:361-72 pubmed
    ..We report that dexamethasone increases both retinoid X receptor-alpha (RXRalpha) and PXR mRNA expression in cultured human hepatocytes, whereas PXR activators such as rifampicin and ..
  23. Lefebvre B, Benomar Y, Guédin A, Langlois A, Hennuyer N, Dumont J, et al. Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans. J Clin Invest. 2010;120:1454-68 pubmed publisher
    ..L1 (UCH-L1) and with increased degradation of the PPARgamma heterodimerization partner retinoid X receptor alpha (RXRalpha), but not RXRbeta, in visceral WAT from obese humans and mice...
  24. Meester Smoor M, Janssen M, Ter Haar W, van Wely K, Aarnoudse A, van Oord G, et al. The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation. PLoS ONE. 2011;6:e23620 pubmed publisher
    ..We have shown that repression by TEL does not involve recruitment of histone deacetylases and suggest that polycomb group proteins participate in the process. ..
  25. Hao X, Chen P, Chen Z, Li S, Wang Y. Evaluating the Association between Keratoconus and Reported Genetic Loci in a Han Chinese Population. Ophthalmic Genet. 2015;36:132-6 pubmed publisher
  26. Li S, Zhou Q, He H, Zhao Y, Liu Z. Peroxisome proliferator-activated receptor ? agonists induce cell cycle arrest through transcriptional regulation of Kruppel-like factor 4 (KLF4). J Biol Chem. 2013;288:4076-84 pubmed publisher
  27. Zitnik R, Kotloff R, Latifpour J, Zheng T, Whiting N, Schwalb J, et al. Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts. J Immunol. 1994;152:1419-27 pubmed
    ..These studies demonstrate that RA and other retinoid analogs inhibit IL-1-induced IL-6 production and that this effect is analog-specific and, at least partially, transcriptionally mediated. ..
  28. Wallace B, Betts L, Talmage G, Pollet R, Holman N, Redinbo M. Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα. J Mol Biol. 2013;425:2561-77 pubmed publisher
    ..Taken together, these data advance our understanding of PXR, the master regulator of drug metabolism gene expression in humans, in its functional partnership with RXRα. ..
  29. Tang J, Zhong G, Zhang H, Yu B, Wei F, Luo L, et al. LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA. Cell Death Dis. 2018;9:1167 pubmed publisher
    ..Taken together, Our findings identified DANCR as an pro-oncogene and uncoverd a new working pattern of lncRNA to mediate TNBC tumorigenesis, which may be a potential therapeutic target for improving treatment of TNBC. ..
  30. Holdsworth Carson S, Permezel M, Riley C, Rice G, Lappas M. Peroxisome proliferator-activated receptors and retinoid X receptor-alpha in term human gestational tissues: tissue specific and labour-associated changes. Placenta. 2009;30:176-86 pubmed publisher
    ..therefore, was to identify tissue and labour-associated changes of PPAR isoforms (alpha, delta and gamma) and RXRalpha in placenta, amnion and choriodecidua...
  31. Hu K, Chen F, Ge J, Cao L, Li H. Retinoid receptors in gastric cancer: expression and influence on prognosis. Asian Pac J Cancer Prev. 2012;13:1809-17 pubmed
    ..This study provides a molecular basis for the therapeutic use of retinoids against gastric cancer. ..
  32. Sun J, Narayanasamy S, Curley R, Harrison E. β-Apo-13-carotenone regulates retinoid X receptor transcriptional activity through tetramerization of the receptor. J Biol Chem. 2014;289:33118-24 pubmed publisher
    ..These observations suggest that β-apo-13-carotenone regulates RXRα transcriptional activity by inducing the formation of the "transcriptionally silent" RXRα tetramer. ..
  33. Soko N, Chimusa E, Masimirembwa C, Dandara C. An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C. Pharmacogenomics J. 2018;: pubmed publisher
    ..Interindividual differences in the pharmacokinetics of rosuvastatin in this African cohort cannot be explained by the polymorphisms SLCO1B1 c.521T>C and ABCG2 c.421C>A, but appear driven by a different set of variants. ..
  34. Chen F, Figueroa D, Marmorstein A, Zhang Q, Petrukhin K, Caskey C, et al. Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells. Proc Natl Acad Sci U S A. 1999;96:15149-54 pubmed
  35. Ko L, Cardona G, Henrion Caude A, Chin W. Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors. Mol Cell Biol. 2002;22:357-69 pubmed
    ..These data suggest that GT198 is a tissue-specific, kinase-regulated nuclear receptor coactivator that interacts with the DNA-binding domains of nuclear receptors. ..
  36. Farooqui M, Franco P, Thompson J, Kagechika H, Chandraratna R, Banaszak L, et al. Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity. Biochemistry. 2003;42:971-9 pubmed
    ..Competition and mutation studies demonstrated an essential role for (1067)Asn and (1073)Met for a ligand-dependent interaction. A model was proposed to address the constitutive and agonist-dependent interaction of RIP140 with RAR/RXR. ..
  37. Tagami T, Yamamoto H, Moriyama K, Sawai K, Usui T, Shimatsu A, et al. The retinoid X receptor binding to the thyroid hormone receptor: relationship with cofactor binding and transcriptional activity. J Mol Endocrinol. 2009;42:415-28 pubmed publisher
  38. Hamdan F, Johnsen S. DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor network. Proc Natl Acad Sci U S A. 2018;115:E12343-E12352 pubmed publisher
  39. Tagami T, Yamamoto H, Moriyama K, Sawai K, Usui T, Shimatsu A, et al. A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones. Endocrinology. 2009;150:862-70 pubmed publisher
  40. Xu L, Zeng Z, Zhang W, Ren G, Ling X, Huang F, et al. RXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent manner. Oncotarget. 2017;8:12311-12322 pubmed publisher
    ..Hence, RXRα ligand Z-10 and its derivatives could target both ATRA- sensitive and resistant APL cells through their distinct acting mechanism, and are potential drug leads for APL treatment. ..
  41. Gaillard E, Bruck N, Brelivet Y, Bour G, Lalevée S, Bauer A, et al. Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7. Proc Natl Acad Sci U S A. 2006;103:9548-53 pubmed
    ..Finally, it results in higher DNA-binding efficiency, providing an explanation for how cAMP synergizes with retinoic acid for transcription. ..
  42. Gao X, Gauderman W, Liu Y, Marjoram P, Torres M, Haritunians T, et al. A genome-wide association study of central corneal thickness in Latinos. Invest Ophthalmol Vis Sci. 2013;54:2435-43 pubmed publisher
    ..We discovered novel SNPs for CCT in Latinos and provided the first reported evidence of the corneal expression of LOC100506532. These results help to further increase our understanding of the genetic architecture of CCT. ..
  43. Thenot S, Henriquet C, Rochefort H, Cavailles V. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. J Biol Chem. 1997;272:12062-8 pubmed
    ..Finally, we show that the interaction of hTIF1 with receptors is selective since strong in vitro hormone-dependent binding is only observed with some members of the nuclear receptor superfamily. ..
  44. Osburn D, Shao G, Seidel H, Schulman I. Ligand-dependent degradation of retinoid X receptors does not require transcriptional activity or coactivator interactions. Mol Cell Biol. 2001;21:4909-18 pubmed
    ..Taken together, the data suggest a model for targeted destruction of transcription factors based on structural or conformational signals as opposed to functional coupling with gene transcription. ..
  45. Georgescu S, Li J, Lu Q, Karas R, Brown M, Mendelsohn M. Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alpha. Mol Endocrinol. 2005;19:2491-501 pubmed
    ..These data identify MRF1 as a repressor of ERalpha-mediated transcriptional activation and support a role for MRF1 in regulating ER-dependent gene expression in cardiovascular and other cells. ..
  46. Winkler G, Mulder K, Bardwell V, Kalkhoven E, Timmers H. Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. EMBO J. 2006;25:3089-99 pubmed
    ..These findings define a function for the human Ccr4-Not complex as a transcriptional repressor of nuclear receptor signalling that is relevant for the understanding of molecular pathways involved in cancer. ..
  47. Castellano Castillo D, Moreno Indias I, Sanchez Alcoholado L, Ramos Molina B, Alcaide Torres J, Morcillo S, et al. Altered Adipose Tissue DNA Methylation Status in Metabolic Syndrome: Relationships Between Global DNA Methylation and Specific Methylation at Adipogenic, Lipid Metabolism and Inflammatory Candidate Genes and Metabolic Variables. J Clin Med. 2019;8: pubmed publisher
  48. Bildirici I, Roh C, Schaiff W, Lewkowski B, Nelson D, Sadovsky Y. The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X receptor. J Clin Endocrinol Metab. 2003;88:6056-62 pubmed
    ..We conclude that the expression of adipophilin is enhanced during trophoblast differentiation and is up-regulated by ligand-activated PPARgamma/RXR. Enhanced adipophilin expression may contribute to fatty acid uptake by the placenta. ..
  49. Feng J, Chen J, Yan J, Jones I, Craddock N, Cook E, et al. Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. Am J Med Genet B Neuropsychiatr Genet. 2005;133B:50-3 pubmed
    ..One uncommon missense variant was found in each of the RARbeta, RARgamma, and RXRgamma genes. We conclude that structural variants in the RAR/RXR and NURR1 genes do not play a major role in the etiology of schizophrenia. ..
  50. Papi A, De Carolis S, Bertoni S, Storci G, Sceberras V, Santini D, et al. PPARγ and RXR ligands disrupt the inflammatory cross-talk in the hypoxic breast cancer stem cells niche. J Cell Physiol. 2014;229:1595-606 pubmed publisher
    ..In conclusion, NRs agonists disrupt the inflammatory cross-talk of the hypoxic breast CSCs niche. ..
  51. Abu Amero K, Helwa I, Al Muammar A, Strickland S, Hauser M, Allingham R, et al. Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population. J Negat Results Biomed. 2015;14:10 pubmed publisher
    ..This report aims at supporting the possible association between CCT-associated SNPs and KC susceptibility. ..
  52. Folkers G, van der Saag P. Adenovirus E1A functions as a cofactor for retinoic acid receptor beta (RAR beta) through direct interaction with RAR beta. Mol Cell Biol. 1995;15:5868-78 pubmed
    ..We propose that E1A functions as a cofactor by interacting with both TBP and RAR, thereby stabilizing the preinitiation complex. ..
  53. Farboud B, Hauksdottir H, Wu Y, Privalsky M. Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression. Mol Cell Biol. 2003;23:2844-58 pubmed
    ..We refer to this phenomenon as a "gate-latch" model of corepressor regulation. ..
  54. Ovsyannikova I, Dhiman N, Haralambieva I, Vierkant R, O Byrne M, Jacobson R, et al. Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. Hum Genet. 2010;127:207-21 pubmed publisher
    ..This is the first paper to present evidence that polymorphisms in the TLR, vitamin A, vitamin D receptor, and innate immunity genes can influence adaptive cytokine responses to rubella vaccination. ..
  55. McKinney B, Lareau C, Oberg A, Kennedy R, Ovsyannikova I, Poland G. The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine. PLoS ONE. 2016;11:e0158016 pubmed publisher
    ..The integrative analysis spotlights the role of genes related to retinoid X receptor alpha (RXRA), which has been implicated in a previous epistasis network analysis of smallpox vaccine. ..
  56. O Brien K, Sandler D, Kinyamu H, Taylor J, Weinberg C. Single-Nucleotide Polymorphisms in Vitamin D-Related Genes May Modify Vitamin D-Breast Cancer Associations. Cancer Epidemiol Biomarkers Prev. 2017;26:1761-1771 pubmed publisher
    ..b>Impact: This work strengthens the evidence for protective effects of vitamin D. Cancer Epidemiol Biomarkers Prev; 26(12); 1761-71. ©2017 AACR. ..
  57. Ray D, Spinelli S, Pollock S, Murant T, O Brien J, Blumberg N, et al. Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles. Thromb Haemost. 2008;99:86-95 pubmed publisher
  58. Adlakha Y, Khanna S, Singh R, Singh V, Agrawal A, Saini N. Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXR? expression and cholesterol homeostasis. Cell Death Dis. 2013;4:e780 pubmed publisher
    ..In this study, we provide the first evidence of miR-128-2 to be a new regulator of cholesterol homeostasis. Our study shows dual role of miR-128-2, as a pro-apoptotic molecule as well as a regulator of cholesterol homeostasis...
  59. Qiu J, Zeisig B, Li S, Liu W, Chu H, Song Y, et al. Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia. Leukemia. 2015;29:1153-62 pubmed publisher
    ..Together, these results indicate that deregulation of the retinoid/rexinoid signaling pathway has a major role and may represent a potential therapeutic target for NUP98-RARG-mediated transformation. ..
  60. Wang A, Avramopoulos D, Lori A, MULLE J, Conneely K, Powers A, et al. Genome-wide association study in two populations to determine genetic variants associated with Toxoplasma gondii infection and relationship to schizophrenia risk. Prog Neuropsychopharmacol Biol Psychiatry. 2019;92:133-147 pubmed publisher
    ..These data provide new insights into the pathophysiology of this common neurotropic parasite. ..
  61. Heyman R, Mangelsdorf D, Dyck J, Stein R, Eichele G, Evans R, et al. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell. 1992;68:397-406 pubmed
    ..The discovery of this novel hormone points to the key role retinoid metabolism may have in generating new signaling pathways. ..
  62. Lee J, Ryan F, Swaffield J, Johnston S, Moore D. Interaction of thyroid-hormone receptor with a conserved transcriptional mediator. Nature. 1995;374:91-4 pubmed
    ..Here we show that Trip1 can functionally substitute for Sug1 in yeast, and that both proteins interact in vitro with the thyroid-hormone receptor, and with the transcriptional activation domains of yeast GAL4 and of herpes virus VP16. ..
  63. Ogawa H, Komatsu T, Hiraoka Y, Morohashi K. Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated nuclear receptor Ad4BP/SF-1. Mol Biol Cell. 2009;20:4235-45 pubmed publisher
    ..These findings suggest that ARIP4 may be a cofactor that modulates SUMO-mediated fine-tuning of transcriptional suppression. ..
  64. Karami S, Brennan P, Rosenberg P, Navratilova M, Mates D, Zaridze D, et al. Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk. PLoS ONE. 2009;4:e7013 pubmed publisher
    ..This study comprehensively evaluated genetic variation across eight vitamin D pathway genes in relation to RCC risk. We found increased risk associated with VDR and RXRA. Replication studies are warranted to confirm these findings. ..
  65. Garcia Bates T, Baglole C, Bernard M, Murant T, Simpson Haidaris P, Phipps R. Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation. J Immunol. 2009;183:6903-12 pubmed publisher
    ..Herein, we examined the role of the peroxisome proliferator-activated receptor (PPAR)gamma/RXRalpha pathway on human B cell differentiation...
  66. Chesney R, Han X. Differential regulation of TauT by calcitriol and retinoic acid via VDR/RXR in LLC-PK1 and MCF-7 cells. Adv Exp Med Biol. 2013;776:291-305 pubmed publisher
    ..Our results show that expression of TauT is differentially regulated by VD(3) and RA via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner. ..
  67. Mangelsdorf D, Umesono K, Kliewer S, Borgmeyer U, Ong E, Evans R. A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. Cell. 1991;66:555-61 pubmed
    ..The discovery of this new RX response element provides a means for distinguishing between the two retinoid receptor systems and suggests that an RXR-mediated pathway exists for modulating vitamin A metabolism. ..
  68. Andreotti G, Menashe I, Chen J, Chang S, Rashid A, Gao Y, et al. Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China. Eur J Epidemiol. 2009;24:763-74 pubmed publisher
    ..These findings provide insight into the role of lipid metabolism genes, as well as the mechanisms by which these genes may be linked with disease. ..
  69. Giardina C, Nakanishi M, Khan A, Kuratnik A, Xu W, Brenner B, et al. Regulation of VDR Expression in Apc-Mutant Mice, Human Colon Cancers and Adenomas. Cancer Prev Res (Phila). 2015;8:387-99 pubmed publisher
    ..Determining the mechanisms of VDR regulation in colon neoplasms may significantly enhance our ability to use vitamin D as a cancer prevention agent. ..
  70. Lee W, Jena S, Rodríguez E, O Donovan S, Wagner C, Jurutka P, et al. Distinct functional modes of SUMOylation for retinoid X receptor alpha. Biochem Biophys Res Commun. 2015;464:195-200 pubmed publisher
    ..Our findings highlight combinatorial effects of SUMOylation may regulate RXRα-directed signalling in a gene-specific fashion. ..
  71. Qiu J, Lu X, Zeisig B, Ma Z, Cai X, Chen S, et al. Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}. Blood. 2010;115:643-52 pubmed publisher
    ..was able to bind to a panel of retinoic acid response elements both as a homodimer and as a heterodimer with RXRalpha, and demonstrated distinct DNA-binding characteristics compared with wild-type RARalpha/RXRalpha or other X-..
  72. Janakiram N, Mohammed A, Zhang Y, Brewer M, Bryant T, Lightfoot S, et al. Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats. Cancer Prev Res (Phila). 2013;6:1251-61 pubmed publisher
    ..The combination of low doses of raloxifene and bexarotene significantly suppressed the progression of colonic adenomas to adenocarcinomas and may be useful for colon cancer prevention and/or treatment in high-risk individuals. ..
  73. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 1996;85:403-14 pubmed
  74. Huang N, vom Baur E, Garnier J, Lerouge T, Vonesch J, Lutz Y, et al. Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators. EMBO J. 1998;17:3398-412 pubmed
    ..Interestingly, NSD1 contains separate repression and activation domains. Thus, NSD1 may define a novel class of bifunctional transcriptional intermediary factors playing distinct roles in both the presence and absence of ligand. ..
  75. Burrage P, Schmucker A, Ren Y, Sporn M, Brinckerhoff C. Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression. Arthritis Res Ther. 2008;10:R139 pubmed publisher
    ..We conclude that the efficacy of combined treatment with lower doses of each drug may minimize potential side effects of treatment with these compounds. ..
  76. White D, Takeda T, DeGroot L, Stefansson K, Arnason B. Beta-trace gene expression is regulated by a core promoter and a distal thyroid hormone response element. J Biol Chem. 1997;272:14387-93 pubmed
    ..We have shown that a gene active in the choroid plexus and meninges is responsive to T3. T3 may play a role in the regulated transport of substances into the cerebrospinal fluid and ultimately the brain. ..
  77. Boudjelal M, Voorhees J, Fisher G. Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells. Exp Cell Res. 2002;274:130-7 pubmed
    ..Treatment of HaCaT cells with all-trans-retinoic acid or 9-cis-retinoic acid reduced RARgamma and RXRalpha protein levels by one-half within 24 h...
  78. Flajollet S, Lefebvre B, Cudejko C, Staels B, Lefebvre P. The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor. Mol Cell Endocrinol. 2007;270:23-32 pubmed
    ..This coactivating property is dependent on SRC1 expression, showing that HATs and SWI/SNF cooperate in this retinoid-controlled transcriptional process. ..
  79. Han S, Li T, Ellis E, Strom S, Chiang J. A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. Mol Endocrinol. 2010;24:1151-64 pubmed publisher
    ..nuclear receptor corepressor-1 and silencing mediator of retinoid and thyroid with VDR/retinoid X receptor-alpha (RXRalpha)...
  80. Berrodin T, Marks M, Ozato K, Linney E, Lazar M. Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. Mol Endocrinol. 1992;6:1468-78 pubmed
  81. Yasumo H, Masuda N, Furusawa T, Tsukamoto T, Sadano H, Osumi T. Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors. Biochim Biophys Acta. 2000;1490:189-97 pubmed
    ..NRBF-2 exhibited a gene activation function, when tethered to a heterologous DNA binding domain, in both mammalian cells and yeast. ..
  82. Andersson E, Rosdahl I, Torma H, Vahlquist A. Differential effects of UV irradiation on nuclear retinoid receptor levels in cultured keratinocytes and melanocytes. Exp Dermatol. 2003;12:563-71 pubmed
    ..UV irradiation on the expression of the predominant retinoid receptors in the human skin (RARalpha, RARgamma and RXRalpha) and the AP-1 protein c-Jun; mRNA levels were studied by real-time PCR and protein levels by Western blot...
  83. Lengqvist J, Mata de Urquiza A, Bergman A, Willson T, Sjövall J, Perlmann T, et al. Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain. Mol Cell Proteomics. 2004;3:692-703 pubmed
    ..In additional experiments, the binding of fatty acid ligands to RXRalpha is directly demonstrated by electrospray mass spectrometry of the noncovalent complex between the RXR ligand-..
  84. Shi H, Yu X, Li Q, Ye X, Gao Y, Ma J, et al. Association between PPAR-? and RXR-? gene polymorphism and metabolic syndrome risk: a case-control study of a Chinese Han population. Arch Med Res. 2012;43:233-42 pubmed publisher
    ..0107). The present study suggested that the variant genotypes in PPAR-? gene could increase the risk of MetS; however, genotypes in RXR-? gene could decrease the risk of MetS in a Chinese Han population. ..
  85. Lou X, Toresson G, Benod C, Suh J, Philips K, Webb P, et al. Structure of the retinoid X receptor ?-liver X receptor ? (RXR?-LXR?) heterodimer on DNA. Nat Struct Mol Biol. 2014;21:277-81 pubmed publisher
    ..Comparisons of RXR?-LXR?s in the crystal asymmetric unit and with previous NR structures reveal flexibility in NR organization and suggest a role for RXR? in adaptation of heterodimeric complexes to DNA. ..
  86. Jeyakumar M, Tanen M, Bagchi M. Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor. Mol Endocrinol. 1997;11:755-67 pubmed
    ..Our results raise the interesting possibility that a RXR-specific ligand may modulate T3-mediated signaling by inducing additional interactions between TRE-bound TR-RXR heterodimer and the coactivator. ..