Gene Symbol: RUVBL1
Description: RuvB like AAA ATPase 1
Alias: ECP-54, ECP54, INO80H, NMP 238, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49, TIP49A, ruvB-like 1, 49 kDa TATA box-binding protein-interacting protein, 49 kDa TBP-interacting protein, 54 kDa erythrocyte cytosolic protein, INO80 complex subunit H, RuvB (E coli homolog)-like 1, RuvB-like AAA ATPase, TAP54-alpha, TATA binding protein interacting protein 49 kDa, TIP60-associated protein 54-alpha, nuclear matrix protein 238, pontin 52
Species: human
Products:     RUVBL1

Top Publications

  1. Venteicher A, Meng Z, Mason P, Veenstra T, Artandi S. Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell. 2008;132:945-57 pubmed publisher
    ..Here, we identify the ATPases pontin and reptin as telomerase components through affinity purification of TERT from human cells...
  2. Cai Y, Jin J, Yao T, Gottschalk A, Swanson S, Wu S, et al. YY1 functions with INO80 to activate transcription. Nat Struct Mol Biol. 2007;14:872-4 pubmed
    ..Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters. ..
  3. Ikura T, Ogryzko V, Grigoriev M, Groisman R, Wang J, Horikoshi M, et al. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell. 2000;102:463-73 pubmed
    ..These results indicate that the histone acetylase TIP60-containing complex plays a role in DNA repair and apoptosis. ..
  4. López Perrote A, Muñoz Hernández H, Gil D, Llorca O. Conformational transitions regulate the exposure of a DNA-binding domain in the RuvBL1-RuvBL2 complex. Nucleic Acids Res. 2012;40:11086-99 pubmed publisher
    RuvBL1 and RuvBL2, also known as Pontin and Reptin, are AAA+ proteins essential in small nucleolar ribonucloprotein biogenesis, chromatin remodelling, nonsense-mediated messenger RNA decay and telomerase assembly, among other functions...
  5. McKeegan K, Debieux C, Watkins N. Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis. Mol Cell Biol. 2009;29:4971-81 pubmed publisher
    The box C/D small nucleolar RNPs (snoRNPs) are essential for the processing and modification of rRNA. TIP48 and TIP49 are two related AAA(+) proteins that are essential for the formation of box C/D snoRNPs...
  6. Qiu X, Lin Y, Thome K, Pian P, Schlegel B, Weremowicz S, et al. An eukaryotic RuvB-like protein (RUVBL1) essential for growth. J Biol Chem. 1998;273:27786-93 pubmed
    A human protein (RUVBL1), consisting of 456 amino acids (50 kDa) and highly homologous to RuvB, was identified by using the 14-kDa subunit of replication protein A (hsRPA3) as bait in a yeast two-hybrid system...
  7. Doyon Y, Selleck W, Lane W, Tan S, Cote J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol. 2004;24:1884-96 pubmed
    ..In conclusion, the NuA4 HAT complex is highly conserved in eukaryotes, in which it plays primary roles in transcription, cellular response to DNA damage, and cell cycle control. ..
  8. Jin J, Cai Y, Yao T, Gottschalk A, Florens L, Swanson S, et al. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. J Biol Chem. 2005;280:41207-12 pubmed
    The mammalian Tip49a and Tip49b proteins belong to an evolutionarily conserved family of AAA+ ATPases...
  9. Haurie V, Ménard L, Nicou A, Touriol C, Metzler P, Fernandez J, et al. Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism. Hepatology. 2009;50:1871-83 pubmed publisher
    Reptin and Pontin are related ATPases associated with stoichiometric amounts in several complexes involved in chromatin remodeling, transcriptional regulation, and telomerase activity...

More Information


  1. Gospodinov A, Tsaneva I, Anachkova B. RAD51 foci formation in response to DNA damage is modulated by TIP49. Int J Biochem Cell Biol. 2009;41:925-33 pubmed publisher
    ..b>TIP49 is highly conserved component of chromatin modification/remodeling complexes, but its involvement in homologous ..
  2. Kanemaki M, Kurokawa Y, Matsu ura T, Makino Y, Masani A, Okazaki K, et al. TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a. J Biol Chem. 1999;274:22437-44 pubmed
    We previously reported that TIP49a is a novel mammalian DNA helicase showing structural similarity with the bacterial recombination factor RuvB...
  3. Puri T, Wendler P, Sigala B, Saibil H, Tsaneva I. Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex. J Mol Biol. 2007;366:179-92 pubmed
    TIP48 and TIP49 are two related and highly conserved eukaryotic AAA(+) proteins with an essential biological function and a critical role in major pathways that are closely linked to cancer...
  4. Niewiarowski A, Bradley A, Gor J, McKay A, Perkins S, Tsaneva I. Oligomeric assembly and interactions within the human RuvB-like RuvBL1 and RuvBL2 complexes. Biochem J. 2010;429:113-25 pubmed publisher
    The two closely related eukaryotic AAA+ proteins (ATPases associated with various cellular activities), RuvBL1 (RuvB-like 1) and RuvBL2, are essential components of large multi-protein complexes involved in diverse cellular processes...
  5. Wu S, Shi Y, Mulligan P, Gay F, Landry J, Liu H, et al. A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Nat Struct Mol Biol. 2007;14:1165-72 pubmed
    ..Collectively, these observations reveal a link between YY1 and INO80 and roles for both in HRR, providing new insight into mechanisms that control the cellular response to genotoxic stress. ..
  6. Kim J, Kim B, Cai L, Choi H, Ohgi K, Tran C, et al. Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature. 2005;434:921-6 pubmed
  7. Gnatovskiy L, Mita P, Levy D. The human RVB complex is required for efficient transcription of type I interferon-stimulated genes. Mol Cell Biol. 2013;33:3817-25 pubmed publisher
    ..Human RVB1 and RVB2, which are highly conserved AAA(+) ATP binding proteins contained in chromatin-remodeling complexes such ..
  8. Breig O, Bras S, Martinez Soria N, Osman D, Heidenreich O, Haenlin M, et al. Pontin is a critical regulator for AML1-ETO-induced leukemia. Leukemia. 2014;28:1271-9 pubmed publisher
    ..Here, using an in vivo RNA interference screen for suppressors of AML1-ETO activity, we identified pontin/RUVBL1 as a gene required for AML1-ETO-induced lethality and blood cell proliferation in Drosophila...
  9. Jha S, Dutta A. RVB1/RVB2: running rings around molecular biology. Mol Cell. 2009;34:521-33 pubmed publisher
    RVB1/RVB2 (also known as Pontin/Reptin, TIP49/TIP48, RuvbL1/RuvbL2, ECP54/ECP51, INO80H/INO80J, TIH1/TIH2, and TIP49A/TIP49B) are two highly conserved members of the AAA+ family that are present in different protein and nucleoprotein ..
  10. Izumi N, Yamashita A, Iwamatsu A, Kurata R, Nakamura H, Saari B, et al. AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. Sci Signal. 2010;3:ra27 pubmed publisher
    ..The adenosine triphosphatases associated with diverse cellular activities (AAA+) family proteins RuvB-like 1 (RUVBL1) and RUVBL2 are involved in various cellular processes, including transcription, RNA modification, DNA repair, and ..
  11. Jha S, Shibata E, Dutta A. Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage. Mol Cell Biol. 2008;28:2690-700 pubmed publisher
    ..Human Rvb1 and Rvb2 are highly conserved AAA(+) ATP binding proteins that are part of various chromatin-remodeling complexes, ..
  12. Horejsi Z, Takai H, Adelman C, Collis S, Flynn H, Maslen S, et al. CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol Cell. 2010;39:839-50 pubmed publisher
    ..We propose that TEL2 acts as a scaffold to coordinate the activities of R2TP/prefoldin-like and HSP90 chaperone complexes during the assembly of the PIKKs. ..
  13. Kanemaki M, Makino Y, Yoshida T, Kishimoto T, Koga A, Yamamoto K, et al. Molecular cloning of a rat 49-kDa TBP-interacting protein (TIP49) that is highly homologous to the bacterial RuvB. Biochem Biophys Res Commun. 1997;235:64-8 pubmed
    ..for affinity-purification of TBP-bound proteins, we isolated a 49-kD protein termed TBP-interacting protein 49 (TIP49) from rat liver nuclear extracts...
  14. Lauscher J, Elezkurtaj S, Dullat S, Lipka S, Gröne J, Buhr H, et al. Increased Pontin expression is a potential predictor for outcome in sporadic colorectal carcinoma. Oncol Rep. 2012;28:1619-24 pubmed publisher
    ..b>Pontin and Reptin are ATPases which are involved in transcriptional regulation, DNA damage repair and ..
  15. Wood M, McMahon S, Cole M. An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. Mol Cell. 2000;5:321-30 pubmed
    ..Two of these proteins were identified as TIP49 and a novel related protein called TIP48, both of which are highly conserved in evolution and contain ATPase/..
  16. Gorynia S, Bandeiras T, Pinho F, McVey C, Vonrhein C, Round A, et al. Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complex. J Struct Biol. 2011;176:279-91 pubmed publisher
    b>RuvBL1 (RuvB-like 1) and its homolog RuvBL2 are evolutionarily highly conserved AAA(+) ATPases essential for many cellular activities. They play an important role in chromatin remodeling, transcriptional regulation and DNA damage repair...
  17. Cai Y, Jin J, Florens L, Swanson S, Kusch T, Li B, et al. The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. J Biol Chem. 2005;280:13665-70 pubmed
    ..Taken together, our findings identify the YL1 protein as a new subunit of the TRRAP/TIP60 HAT complex, and they suggest that YL1 plays multiple roles in chromatin modification and remodeling in cells. ..
  18. Feng Y, Lee N, Fearon E. TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling. Cancer Res. 2003;63:8726-34 pubmed
    ..Factors cooperating with beta-catenin in transcription of TCF-regulated genes are not well defined. TIP49, an ATPase previously implicated as a cofactor for oncogenic transformation by c-Myc, has been shown to bind to ..
  19. Kim J, Lee J, Nam H, Choi H, Yang J, Lee J, et al. SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells. Proc Natl Acad Sci U S A. 2007;104:20793-8 pubmed
    ..Here, we report that pontin, a component of chromatin-remodeling complexes, is SUMO-modified, and that SUMOylation of pontin is an active ..
  20. Matias P, Gorynia S, Donner P, Carrondo M. Crystal structure of the human AAA+ protein RuvBL1. J Biol Chem. 2006;281:38918-29 pubmed
    b>RuvBL1 is an evolutionarily highly conserved eukaryotic protein belonging to the AAA(+)-family of ATPases (ATPase associated with diverse cellular activities)...
  21. Sierra J, Yoshida T, Joazeiro C, Jones K. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev. 2006;20:586-600 pubmed
    ..We conclude that, in addition to regulating the stability of beta-cat, APC facilitates CtBP-mediated repression of Wnt target genes in normal, but not in colorectal cancer cells. ..
  22. López Perrote A, Alatwi H, Torreira E, Ismail A, Ayora S, Downs J, et al. Structure of Yin Yang 1 oligomers that cooperate with RuvBL1-RuvBL2 ATPases. J Biol Chem. 2014;289:22614-29 pubmed publisher
    ..DNA substrates without the consensus sequence for YY1 in vitro, and DNA binding is enhanced in the presence of RuvBL1-RuvBL2, two essential AAA+ ATPases...
  23. Bauer A, Huber O, Kemler R. Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein. Proc Natl Acad Sci U S A. 1998;95:14787-92 pubmed
    ..Here we report the identification of an interaction partner of beta-catenin, a nuclear protein designated Pontin52. Pontin52 binds beta-catenin in the region of Armadillo repeats 2-5 and, more importantly, also binds the TATA ..
  24. Bauer A, Chauvet S, Huber O, Usseglio F, Rothbächer U, Aragnol D, et al. Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity. EMBO J. 2000;19:6121-30 pubmed
    ..We recently identified Pontin52 as a nuclear protein interacting with beta-catenin and the TATA-box binding protein (TBP), suggesting its ..
  25. Cai Y, Jin J, Tomomori Sato C, Sato S, Sorokina I, Parmely T, et al. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. J Biol Chem. 2003;278:42733-6 pubmed
    ..Taken together, our findings shed new light on the structure and function of the mammalian TRRAP/TIP60 histone acetyltransferase complex. ..
  26. Tian S, Yu G, He H, Zhao Y, Liu P, Marshall A, et al. Pih1p-Tah1p Puts a Lid on Hexameric AAA+ ATPases Rvb1/2p. Structure. 2017;25:1519-1529.e4 pubmed publisher
    ..We characterized the structure of the ScR2TP complex made up of two AAA+ ATPases, Rvb1/2p, and two Hsp90 binding proteins, Tah1p and Pih1p, and its interaction with the snoRNP protein Nop58p by a ..
  27. Gorynia S, Matias P, Bandeiras T, Donner P, Carrondo M. Cloning, expression, purification, crystallization and preliminary X-ray analysis of the human RuvBL1-RuvBL2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:840-6 pubmed publisher
    The complex of RuvBL1 and its homologue RuvBL2, two evolutionarily highly conserved eukaryotic proteins belonging to the AAA(+) (ATPase associated with diverse cellular activities) family of ATPases, was co-expressed in Escherichia coli...
  28. Paci A, Liu P, Zhang L, Zhao R. The Proteasome Subunit Rpn8 Interacts with the Small Nucleolar RNA Protein (snoRNP) Assembly Protein Pih1 and Mediates Its Ubiquitin-independent Degradation in Saccharomyces cerevisiae. J Biol Chem. 2016;291:11761-75 pubmed publisher
    Pih1 is a scaffold protein of the Rvb1-Rvb2-Tah1-Pih1 (R2TP) protein complex, which is conserved in fungi and animals...
  29. Makino Y, Mimori T, Koike C, Kanemaki M, Kurokawa Y, Inoue S, et al. TIP49, homologous to the bacterial DNA helicase RuvB, acts as an autoantigen in human. Biochem Biophys Res Commun. 1998;245:819-23 pubmed
    ..We have isolated a novel human cDNA for a 49-kD TBP-interacting protein (TIP49)...
  30. Negishi M, Chiba T, Saraya A, Miyagi S, Iwama A. Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process. Genes Cells. 2009;14:1347-57 pubmed publisher
    ..These findings indicate that Dmap1 is required to involve Pcna in DNA repair. Together, Dmap1 plays a crucial role in DNA repair, and is indispensable for the maintenance of chromosomal integrity. ..
  31. Salzer U, Kubicek M, Prohaska R. Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins. Biochim Biophys Acta. 1999;1446:365-70 pubmed
    ..2% amino acid identity) and contain ATP-binding sites. ECP-54 was identified as TIP49/RUVBL1/NMP238, which is a component of a large nuclear protein complex, possibly the RNA polymerase II holoenzyme; ECP-51 ..
  32. Carlson M, Wilson E, Prescott S. Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a. Mol Cancer. 2003;2:42 pubmed
    ..cancer cell line, and in patients, is associated with overexpression of the Wnt pathway-associated proteins, Pontin52/TIP49a and LEF-1...
  33. De Planell Saguer M, Schroeder D, Rodicio M, Cox G, Mourelatos Z. Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery. Hum Mol Genet. 2009;18:2115-26 pubmed publisher
    ..factor IIIC-220 kDa (TFIIIC220), an essential factor required for tRNA transcription, and the helicases Reptin and Pontin, which function in transcription and in ribosome biogenesis, are also part of IGHMBP2-containing complexes...
  34. Runge J, Raab J, Magnuson T. Identification of Two Distinct Classes of the Human INO80 Complex Genome-Wide. G3 (Bethesda). 2018;8:1095-1102 pubmed publisher
    ..was enriched for open chromatin, H3K27ac, and representative subunits from each of the three INO80-C modules (RUVBL1, RUVBL2, MCRS1, YY1). We named this class Canonical INO80...
  35. David Morrison G, Xu Z, Rui Y, Charng W, Jaiswal M, Yamamoto S, et al. WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes. Dev Cell. 2016;36:139-51 pubmed publisher
    ..The assembly of the TTT-Pontin/Reptin complex is responsive to changes in energy status...
  36. Rajendra E, Garaycoechea J, Patel K, Passmore L. Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases. Nucleic Acids Res. 2014;42:13736-48 pubmed publisher
    ..Here, we show that the RuvBL1 and RuvBL2 AAA+ ATPases co-purify with FA core complex isolated under stringent but native conditions from a ..
  37. Sugimoto K. Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases. Curr Genet. 2018;64:965-970 pubmed publisher
    ..Several lines of evidence have established a model in which TTT connects to the Hsp90 chaperone through the Rvb1-Rvb2-Tah1-Pih1 (R2TP) complex in mammalian and yeast cells...
  38. Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, et al. MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks. J Cell Sci. 2010;123:1124-30 pubmed publisher
    ..These results suggest that MRG15 mediates DNA-damage-response functions of the BRCA complex in chromatin. ..
  39. Notaridou M, Quaye L, Dafou D, Jones C, Song H, Høgdall E, et al. Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer. Int J Cancer. 2011;128:2063-74 pubmed publisher
    ..suppression of tumorogenicity in ovarian cancer cell lines; AIFM2, AKTIP, AXIN2, CASP5, FILIP1L, RBBP8, RGC32, RUVBL1 and STAG3...
  40. Willhoft O, Bythell Douglas R, McCormack E, Wigley D. Synergy and antagonism in regulation of recombinant human INO80 chromatin remodeling complex. Nucleic Acids Res. 2016;44:8179-88 pubmed publisher
    ..N-terminally truncated Ino80, actin, Arp4, Arp5, Arp8, Ies2 and Ies6, together with a single heterohexamer of the Tip49a and Tip49b proteins...
  41. Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, et al. The p400 complex is an essential E1A transformation target. Cell. 2001;106:297-307 pubmed
    ..Furthermore, E1A and c-myc each alter the subunit composition of p400 complexes, implying that physiological p400 complex formation contributes to transformation suppression. ..
  42. Quéval R, Papin C, Dalvai M, Bystricky K, Humbert O. Reptin and Pontin oligomerization and activity are modulated through histone H3 N-terminal tail interaction. J Biol Chem. 2014;289:33999-4012 pubmed publisher
    Pontin/RUVBL1 and Reptin/RUVBL2 are DNA-dependent ATPases involved in numerous cellular processes and are essential components of chromatin remodeling complexes and transcription factor assemblies...
  43. Fan W, Xie J, Xia J, Zhang Y, Yang M, Wang H, et al. RUVBL1-ITFG1 interaction is required for collective invasion in breast cancer. Biochim Biophys Acta Gen Subj. 2017;1861:1788-1800 pubmed publisher
    ..The ATPase RUVBL1 is frequently overexpressed in various cancers and plays a crucial role in oncogenic process...
  44. McKeegan K, Debieux C, Boulon S, Bertrand E, Watkins N. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. Mol Cell Biol. 2007;27:6782-93 pubmed
    ..four novel human biogenesis factors (BCD1, NOP17, NUFIP, and TAF9) which, along with the ATPases TIP48 and TIP49, are likely to be involved in the formation of the pre-snoRNP...
  45. Freund A, Zhong F, Venteicher A, Meng Z, Veenstra T, Frydman J, et al. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. Cell. 2014;159:1389-403 pubmed publisher
    ..Our findings establish a critical role for TRiC-mediated protein folding in the telomerase pathway and link proteostasis, telomere maintenance, and human disease. ..
  46. Li Y, Zhao L, Yuan S, Zhang J, Sun Z. Axonemal dynein assembly requires the R2TP complex component Pontin. Development. 2017;144:4684-4693 pubmed publisher
    b>Pontin (Ruvbl1) and Reptin (Ruvbl2) are closely related AAA ATPases. They are components of the Ruvbl1-Ruvbl2-Tah1-Pih1 (R2TP) complexes that function as co-chaperones for the assembly of multiple macromolecular protein complexes...
  47. Rashid S, Pilecka I, Torun A, Olchowik M, Bielinska B, Miaczynska M. Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. J Biol Chem. 2009;284:18115-28 pubmed publisher
    ..We propose that APPL proteins exert their stimulatory effects on beta-catenin/TCF-dependent transcription by decreasing the activity of a Reptin-containing repressive complex. ..
  48. Gartner W, Rossbacher J, Zierhut B, Daneva T, Base W, Weissel M, et al. The ATP-dependent helicase RUVBL1/TIP49a associates with tubulin during mitosis. Cell Motil Cytoskeleton. 2003;56:79-93 pubmed
    RUVBL1/TIP49a/Pontin52 is a recently identified multi-functional protein with 2 ATP binding (WALKER) sites, which is essential for cell proliferation...
  49. Bönisch C, Schneider K, Pünzeler S, Wiedemann S, Bielmeier C, Bocola M, et al. H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. Nucleic Acids Res. 2012;40:5951-64 pubmed
    ..Our findings enrich the list of known human variants by an unusual protein belonging to the H2A.Z family that leads to the least stable nucleosome known to date. ..
  50. Lee J, Kim Y, Bhin J, Shin H, Nam H, Lee S, et al. Hypoxia-induced methylation of a pontin chromatin remodeling factor. Proc Natl Acad Sci U S A. 2011;108:13510-5 pubmed publisher
    b>Pontin is a chromatin remodeling factor that possesses both ATPase and DNA helicase activities...
  51. Giorgio G, Alfieri M, Prattichizzo C, Zullo A, Cairo S, Franco B. Functional characterization of the OFD1 protein reveals a nuclear localization and physical interaction with subunits of a chromatin remodeling complex. Mol Biol Cell. 2007;18:4397-404 pubmed
    ..Interestingly, we identify an OFD1-interacting protein RuvBl1, a protein belonging to the AAA(+)-family of ATPases, which has been recently associated to cystic kidney in ..
  52. Taniuchi K, Furihata M, Iwasaki S, Tanaka K, Shimizu T, Saito M, et al. RUVBL1 directly binds actin filaments and induces formation of cell protrusions to promote pancreatic cancer cell invasion. Int J Oncol. 2014;44:1945-54 pubmed publisher
    We report a novel function of RUVBL1 molecule in pancreatic cancer cells...
  53. Choi H, Lee J, Kim H, Nam H, Shin H, Kim D, et al. Bcl3-dependent stabilization of CtBP1 is crucial for the inhibition of apoptosis and tumor progression in breast cancer. Biochem Biophys Res Commun. 2010;400:396-402 pubmed publisher
    ..Our study reveals a novel combinatorial role for Bcl3 and CtBP1, providing an explanation for the acquisition of resistance to apoptosis in cancer cells, which is a major requirement for cancer development. ..
  54. Quaye L, Dafou D, Ramus S, Song H, Gentry Maharaj A, Maharaj A, et al. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. Hum Mol Genet. 2009;18:1869-78 pubmed publisher
  55. Taniue K, Oda T, Hayashi T, Okuno M, Akiyama T. A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis. EMBO Rep. 2011;12:682-9 pubmed publisher
    ..We found that EHF directly activates the transcription of RUVBL1, an ATPase associated with chromatin-remodelling complexes...
  56. Guo H, Zhang X, Peng J, Huang Y, Yang Y, Liu Y, et al. RUVBL1, a novel C-RAF-binding protein, activates the RAF/MEK/ERK pathway to promote lung cancer tumorigenesis. Biochem Biophys Res Commun. 2018;498:932-939 pubmed publisher
    ..Here, we identified a novel C-RAF-binding protein, RUVBL1, which activates the RAF/MEK/ERK pathway by inhibiting phosphorylation of the C-RAF protein at serine 259...
  57. Hartill V, van de Hoek G, Patel M, Little R, Watson C, Berry I, et al. DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport. Hum Mol Genet. 2018;27:529-545 pubmed publisher
    ..transport protein IFT88 and the AAA+ (ATPases Associated with various cellular Activities) family proteins RUVBL1 (Pontin) and RUVBL2 (Reptin)...
  58. Weiske J, Huber O. The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription. J Cell Sci. 2005;118:3117-29 pubmed
    b>Pontin and Reptin previously were identified as nuclear beta-catenin interaction partners that antagonistically modulate beta-catenin transcriptional activity...
  59. Houry W, Bertrand E, Coulombe B. The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation. Trends Biochem Sci. 2018;43:4-9 pubmed publisher
    The Rvb1-Rvb2-Tah1-Pih1/prefoldin-like (R2TP/PFDL) complex is a unique chaperone that provides a platform for the assembly and maturation of many key multiprotein complexes in mammalian cells...
  60. Zhang X, Ren J, Yan L, Tang Y, Zhang W, Li D, et al. Cytoplasmic expression of pontin in renal cell carcinoma correlates with tumor invasion, metastasis and patients' survival. PLoS ONE. 2015;10:e0118659 pubmed publisher
    ..Recent studies have implicated the AAA+ ATPase pontin in many cellular activities that are highly relevant to carcinogenesis...
  61. Mir R, Bele A, Mirza S, Srivastava S, Olou A, Ammons S, et al. A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression. Mol Cell Biol. 2015;36:886-99 pubmed publisher
    ..Biochemical analyses demonstrated an additional phosphorylation-independent interaction of ECD with the RUVBL1 component of the R2TP complex, and this interaction is essential for ECD's cell cycle progression function...
  62. Afanasyeva A, Yakimov A, Grigoriev M, Petukhov M. [DYNAMICS AND MECHANISMS OF INTERACTION OF HETERO-HEXAMERIC TIP49a/b COMPLEXES WITH DS-DNA]. Tsitologiia. 2015;57:671-8 pubmed
    Evolutionary conserved TIP49a and TIP49b ATPases belong to the AAA+ superfamily of DNA-dependent ATPases that are involved in many cellular processes such as chromatin remodeling, regulation of transcription and cell division during ..
  63. Jeganathan A, Leong V, Zhao L, Huen J, Nano N, Houry W, et al. Yeast rvb1 and rvb2 proteins oligomerize as a conformationally variable dodecamer with low frequency. J Mol Biol. 2015;427:1875-86 pubmed publisher
    b>Rvb1 and Rvb2 are conserved AAA+ (ATPases associated with diverse cellular activities) proteins found at the core of large multicomponent complexes that play key roles in chromatin remodeling, integrity of the telomeres, ribonucleoprotein ..
  64. Obri A, Ouararhni K, Papin C, Diebold M, Padmanabhan K, Marek M, et al. ANP32E is a histone chaperone that removes H2A.Z from chromatin. Nature. 2014;505:648-53 pubmed publisher
    ..Z at specific chromatin control regions, in particular at enhancers and insulators. ..
  65. Ivatt R, Sanchez Martinez A, Godena V, Brown S, Ziviani E, Whitworth A. Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proc Natl Acad Sci U S A. 2014;111:8494-9 pubmed publisher
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