RUNX2

Summary

Gene Symbol: RUNX2
Description: runt-related transcription factor 2
Alias: AML3, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2A1, PEBP2A2, PEBP2aA, PEBP2aA1, CBF-alpha-1, PEA2-alpha A, PEBP2-alpha A, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit, acute myeloid leukemia 3 protein, core-binding factor, runt domain, alpha subunit 1, oncogene AML-3, osteoblast-specific transcription factor 2, polyomavirus enhancer-binding protein 2 alpha A subunit
Species: human

Top Publications

  1. ncbi Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    P Ducy
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston 77030, USA
    Cell 89:747-54. 1997
  2. ncbi Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    F Otto
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, United Kingdom
    Cell 89:765-71. 1997
  3. ncbi Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions
    J Akech
    The Cancer Center Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, MA, USA
    Oncogene 29:811-21. 2010
  4. ncbi Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 68:7795-802. 2008
  5. ncbi Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2
    Daniel W Young
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Nature 445:442-6. 2007
  6. ncbi Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma
    David M Thomas
    Ian Potter Foundation Centre for Cancer Genomics and Predictive Medicine, and Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Center, Victoria, Melbourne, Australia
    J Cell Biol 167:925-34. 2004
  7. ncbi Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3
    Dallas C Jones
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 312:1223-7. 2006
  8. ncbi A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia
    Y W Zhang
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 97:10549-54. 2000
  9. ncbi Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
    S Mundlos
    Kinderklinik, Klinikum der Johannes Gutenberg Universitat, Mainz, Germany
    Cell 89:773-9. 1997
  10. ncbi Runx2 regulates survivin expression in prostate cancer cells
    Minyoung Lim
    Programs in Genetic, Molecular and Cellular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Lab Invest 90:222-33. 2010

Research Grants

  1. Mechanistic Role of NELL-1 in Premature Suture Closure
    Kang Ting; Fiscal Year: 2003
  2. TGF-Beta regulation of Runx2 in bone formation and quality
    Tamara Alliston; Fiscal Year: 2007
  3. In vivo utilization of Runx2 isoforms during skeletal development
    Julie Liu; Fiscal Year: 2007
  4. OSF2/CBFAL AND MURINE ODONTOGENESIS
    RENA D SOUZA; Fiscal Year: 2002
  5. Sex Steroids and Runx Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2010
  6. Sex Steroids and Runx Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2010
  7. Cellular and Molecular Determinants of Tooth Eruption
    Hitesh Kapadia; Fiscal Year: 2005
  8. Expression and Regulation of LEF-1 During Odontogenesis
    Petros Papagerakis; Fiscal Year: 2005
  9. Regulation of Runx2 Function by Twist-1 in Tooth Development
    RENA D SOUZA; Fiscal Year: 2007
  10. Regulation of Runx2 Function by Twist-1 in Tooth Development
    RENA D SOUZA; Fiscal Year: 2009

Detail Information

Publications213 found, 100 shown here

  1. ncbi Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    P Ducy
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston 77030, USA
    Cell 89:747-54. 1997
    ..We have now cloned the cDNA encoding Osf2/Cbfa1, the protein that binds to OSE2...
  2. ncbi Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    F Otto
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, United Kingdom
    Cell 89:765-71. 1997
    We have generated Cbfa1-deficient mice. Homozygous mutants die of respiratory failure shortly after birth. Analysis of their skeletons revealed an absence of osteoblasts and bone...
  3. ncbi Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions
    J Akech
    The Cancer Center Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, MA, USA
    Oncogene 29:811-21. 2010
    b>Runx2, a bone-specific transcriptional regulator, is abnormally expressed in highly metastatic prostate cancer cells. Here, we identified the functional activities of Runx2 in facilitating tumor growth and osteolysis...
  4. ncbi Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 68:7795-802. 2008
    b>Runx2, required for bone formation, is ectopically expressed in breast cancer cells...
  5. ncbi Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2
    Daniel W Young
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Nature 445:442-6. 2007
    ..Runt-related transcription factors Runx1, Runx2 and Runx3 establish and maintain cell identity, and convey phenotypic information through successive cell ..
  6. ncbi Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma
    David M Thomas
    Ian Potter Foundation Centre for Cancer Genomics and Predictive Medicine, and Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Center, Victoria, Melbourne, Australia
    J Cell Biol 167:925-34. 2004
    ..The function of runx2, a master regulator of osteoblast differentiation belonging to the runt family of tumor suppressor genes, is ..
  7. ncbi Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3
    Dallas C Jones
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 312:1223-7. 2006
    ..Shn3 was found to control protein levels of Runx2, the principal transcriptional regulator of osteoblast differentiation, by promoting its degradation through ..
  8. ncbi A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia
    Y W Zhang
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 97:10549-54. 2000
    ..in runt-related gene 2 (RUNX2)/polyomavirus enhancer binding protein 2alphaA (PEBP2alphaA)/core-binding factor A1 (CBFA1)...
  9. ncbi Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
    S Mundlos
    Kinderklinik, Klinikum der Johannes Gutenberg Universitat, Mainz, Germany
    Cell 89:773-9. 1997
    ..In some families, the phenotype segregates with deletions resulting in heterozygous loss of CBFA1, a member of the runt family of transcription factors...
  10. ncbi Runx2 regulates survivin expression in prostate cancer cells
    Minyoung Lim
    Programs in Genetic, Molecular and Cellular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Lab Invest 90:222-33. 2010
    ..Here, for the first time, we identify Runx2 as a key regulator of survivin transcription...
  11. ncbi Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma
    Saminathan S Nathan
    Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore
    Mol Biol Rep 36:153-8. 2009
    ..Molecular analysis reveals OS1 cells express the pocket protein pRB and the runt-related transcription factor Runx2. Strikingly, Runx2 is expressed at higher levels in OS1 cells than in human fetal osteoblasts...
  12. ncbi Craniosynostosis-associated gene nell-1 is regulated by runx2
    Thien Truong
    Dental of Craniofacial Research Institute, University of California, Los Angeles, CA 90095, USA
    J Bone Miner Res 22:7-18. 2007
    ..We identitifed three OSE2 elements in the NELL-1 promoter that are directly bound and transactivated by Runx2. Forced expression of Runx2 induces NELL-1 expression in rat calvarial cells.
  13. ncbi Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
    Rick B Vega
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 119:555-66. 2004
    ..chondrocyte hypertrophy and endochondral bone formation by interacting with and inhibiting the activity of Runx2, a transcription factor necessary for chondrocyte hypertrophy...
  14. ncbi Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo
    Amjad Javed
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 102:1454-9. 2005
    ..We have previously shown that aberrant expression of the Runx2 DNA binding domain in metastatic breast cancer cells can prevent production of osteolytic lesions in bone...
  15. ncbi A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator
    R Yagi
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogo in, Sakyo ku, Kyoto 606 8507, Japan
    EMBO J 18:2551-62. 1999
    ..These results indicate that the PY motif is a novel transcription activation domain that functions by recruiting YAP as a strong transcription activator to target genes...
  16. ncbi ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function
    L Bruhn
    Department of Microbiology, University of California, San Francisco 94143 0414, USA
    Genes Dev 11:640-53. 1997
    ..We propose that ALY mediates context-dependent transcriptional activation by facilitating the functional collaboration of multiple proteins in the TCR alpha enhancer complex...
  17. ncbi Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor
    Z S Xiao
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Gene 214:187-97. 1998
    Although the CBFA1 gene encodes an osteoblast-specific transcription factor that regulates osteoblast differentiation, uncertainty exists about the organization of its 5' end and the relevance of a novel N-terminal sequence identified in ..
  18. ncbi The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion
    Jitesh Pratap
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Mol Cell Biol 25:8581-91. 2005
    The Runx2 (Cbfa1/AML3) transcription factor and matrix metalloproteinase 9 (MMP9) are key regulators of growth plate maturation and bone formation...
  19. ncbi Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 69:6807-14. 2009
    The transcription factor Runx2 is highly expressed in breast cancer cells compared with mammary epithelial cells and contributes to metastasis...
  20. ncbi Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2
    Daniel W Young
    Department of Cell Biology and Cancer Center, Program in Molecular Medicine, and Information Services, University of Massachusetts Medical School, Worcester, MA 01655 0105, USA
    Proc Natl Acad Sci U S A 104:3189-94. 2007
    ..Here we show that Runx2 protein is stable during cell division and remains associated with chromosomes during mitosis through sequence-..
  21. ncbi Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway
    Ya Ling Hsu
    Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    J Biol Chem 286:37335-46. 2011
    ..of lung cancer migration by BMP-2 is associated with increased ERK and p38 activation and the up-regulation of Runx2 and Snail...
  22. ncbi Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity
    Jose Sierra
    Departamento de Biologia Molecular, Facultad de Ciencias Biologicas, Universidad de Concepcion, Concepcion, Chile
    Mol Cell Biol 23:3339-51. 2003
    ..osteoblastic cells, transcription of the bone-specific osteocalcin (OC) gene is principally regulated by the Runx2/Cbfa1 transcription factor and is stimulated in response to vitamin D(3) via the vitamin D(3) receptor complex...
  23. ncbi Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease
    George L Barnes
    Department of Orthopaedic Surgery, Boston University Medical Center, Massachusetts 02118, USA
    Cancer Res 64:4506-13. 2004
    ..We demonstrated recently that breast cancer cells express the Runx2 transcription factor, essential for bone formation and a regulator of skeletal homeostasis...
  24. ncbi Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy
    Bekim Sadikovic
    Department of Pathology and Molecular Medicine, Richardson Labs, Queen s University, Kingston, K7L 3N6 Canada
    BMC Cancer 10:202. 2010
    ..Recent discoveries have highlighted a potential role of a number of genes including: RECQL4, DOCK5, SPP1, RUNX2, RB1, CDKN1A, P53, IBSP, LSAMP, MYC, TNFRSF1B, BMP2, HISTH2BE, FOS, CCNB1, and CDC5L.
  25. ncbi Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation
    Run Shen
    Department of Orthopaedics and Department of Pathology, Center for Musculoskeletal Research, University of Rochester, School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 281:3569-76. 2006
    b>Runx2 is a bone-specific transcription factor that plays a critical role in bone development, postnatal bone formation, and chondrocyte maturation. The protein levels of Runx2 are regulated by the ubiquitin-proteasome pathway...
  26. ncbi Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells
    Naoyuki Makita
    Research Institute for Biological Sciences, Tokyo University of Science, Chiba, Japan
    Gene 413:8-17. 2008
    b>Runx2 is a Runt domain transcription factor that transcriptionally regulates osteoblast differentiation and bone formation...
  27. ncbi Runx2 is expressed in human glioma cells and mediates the expression of galectin-3
    Valentina Vladimirova
    Neuro and Tumor Cell Biology Group, Department of Nuclear Medicine, University of Bonn Medical Center, Bonn, Germany
    J Neurosci Res 86:2450-61. 2008
    b>Runx2 is a member of the Runx family of transcription factors (Runx1-3) with a restricted expression pattern...
  28. ncbi Bone morphogenetic protein-2 stimulates Runx2 acetylation
    Eun Joo Jeon
    Department of Biochemistry, School of Medicine, and Institute for Tumor Research, Chungbuk National University, Cheongju 361 763, Korea
    J Biol Chem 281:16502-11. 2006
    Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic protein (BMP) pathway...
  29. ncbi Prostate cancer expression of runt-domain transcription factor Runx2, a key regulator of osteoblast differentiation and function
    Kristen D Brubaker
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Prostate 56:13-22. 2003
    ..Specific transcription factors, including Runx2, regulate the expression of many bone-related factors in osteoblasts...
  30. ncbi Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
    Brad Sevetson
    Functional Genomics Department, Amgen Corp, Seattle, Washington 98101, USA
    J Biol Chem 279:13849-58. 2004
    ..b>Cbfa1/RUNX2 is a key transcriptional regulator of osteoblast function...
  31. ncbi Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations
    Taketoshi Yoshida
    Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Am J Hum Genet 71:724-38. 2002
    ..heritable skeletal disease caused by heterozygous mutations in the osteoblast-specific transcription factor RUNX2. We have performed mutational analysis of RUNX2 on 24 unrelated patients with CCD...
  32. ncbi RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region
    Marcie Fowler
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 711130, USA
    J Cell Biochem 97:1-17. 2006
    The RUNX transcription factors (RUNX1, RUNX2, and RUNX3) play essential roles in hematopoiesis and skeletal development...
  33. ncbi Identification of novel CBFA1/RUNX2 mutations causing cleidocranial dysplasia
    C Bergwitz
    Abteilung für Klinische Endokrinologie, Hochschule Hannover, Germany
    J Inherit Metab Dis 24:648-56. 2001
    Core binding factor A1 (CBFA1/RUNX2) is a runt-like transcription factor essential for osteoblast differentiation...
  34. ncbi Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter
    Rachel A Kahler
    University of Minnesota Cancer Center, Department of Orthopaedic Surgery and Graduate Program in Microbiology, Immunology and Cancer Biology, Minneapolis, Minnesota 55455, USA
    J Biol Chem 278:11937-44. 2003
    Functional control of the transcription factor Runx2 is crucial for normal bone formation. Runx2 is detectable throughout osteoblast development and maturation and temporally regulates several bone-specific genes...
  35. ncbi Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells
    George L Barnes
    Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Cancer Res 63:2631-7. 2003
    ..Our results demonstrate that Runx2 is ectopically expressed in breast cancer cells and that one isoform of Runx2 can activate bsp expression in these ..
  36. ncbi Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression
    Virginie Lamour
    Metastasis Research Laboratory, Center of Experimental Cancer Research and Bone and Cartilage Metabolism Research Unit, University of Liege, 4000 Liege, Belgium
    J Biol Chem 282:36240-9. 2007
    ..human osteosarcoma cells and in differentiating normal human osteoblasts, concomitantly with the decrease of Runx2, a key transcription factor controlling bone formation...
  37. ncbi Six novel mutations of the RUNX2 gene in Italian patients with cleidocranial dysplasia
    Alessandra Tessa
    Molecular Medicine and Genetics, IRCCS Bambino Gesù, Rome, Italy
    Hum Mutat 22:104. 2003
    ..We identified ten heterozygous base changes in the RUNX2 gene, including six novel mutations [c.522insA, c.389G>A (W130X), c.662T>G (V221G), IVS2+T>A, c...
  38. ncbi BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype
    Mattabhorn Phimphilai
    Department of Biological Chemistry, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 1078, USA
    J Bone Miner Res 21:637-46. 2006
    b>RUNX2 expression in mesenchymal cells induces osteoblast differentiation and bone formation...
  39. ncbi Runx2 phosphorylation induced by fibroblast growth factor-2/protein kinase C pathways
    Byung Gyu Kim
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Jung Gu, Daegu, Korea
    Proteomics 6:1166-74. 2006
    b>Runx2 is a key transcription factor in osteoblast differentiation, and its activity is regulated by fibroblast growth factors (FGFs)...
  40. ncbi Expression and function of Cbfa-1/Runx2 in thyroid papillary carcinoma cells
    Toyoshi Endo
    Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo City, Yamanashi, Japan
    J Clin Endocrinol Metab 93:2409-12. 2008
    ..Development of calcifying foci is a common finding in human thyroid papillary carcinoma, but its mechanisms remain unknown...
  41. ncbi The RUNX genes: gain or loss of function in cancer
    Karen Blyth
    Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, G61 1QH, UK
    Nat Rev Cancer 5:376-87. 2005
    ..have such an ambiguous role in cancer? How and where do these genes impinge on the pathways that regulate growth control and differentiation? And what is the evidence for a wider role for the RUNX genes in non-haematopoietic cancers?..
  42. ncbi Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA
    Sanjeev K Baniwal
    Department Biochemistry and Molecular Biology, Institute of Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Mol Endocrinol 23:1203-14. 2009
    b>Runx2 and androgen receptor (AR) are master transcription factors with pivotal roles in bone metabolism and prostate cancer (PCa)...
  43. ncbi Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway
    Meng Qiao
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, USA
    J Biol Chem 279:42709-18. 2004
    ..b>RUNX2, a member of the Ig-loop family of transcription factors is expressed in vascular endothelial cells (EC) and ..
  44. ncbi Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform
    Chee Wai Chua
    Cancer Biology Group, Department of Anatomy and Departments of Pathology and Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Clin Cancer Res 15:4322-35. 2009
    ..In the present study, we aimed to first verify the role of Runx2 in prostate cancer progression and metastasis, and, subsequently, assessed if FTY720 could modulate Runx2 ..
  45. ncbi Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2
    Marie Bertrand-Philippe
    Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Biol Chem 279:24530-9. 2004
    ..In this study we identify RUNX1 and RUNX2 as UTE-1-binding proteins that are induced at the post-transcriptional level during activation of HSC...
  46. ncbi RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors
    He Yu Zhang
    Department of Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Endocrine 35:101-11. 2009
    ..Two binding sites for RUNX1 and one binding site for RUNX2 were identified in the LGALS3 promoter region...
  47. ncbi Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation
    Richard C D'Alonzo
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 277:816-22. 2002
    ..Here we show that Cbfa1 and c-Fos.c-Jun appear to cooperatively bind the RD- and AP-1-binding sites and form ternary structures in vitro...
  48. ncbi PEBP2alphaA/CBFA1 mutations in Japanese cleidocranial dysplasia patients
    Y W Zhang
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto, Japan
    Gene 244:21-8. 2000
    ..dominant human bone disease whose genetic locus has been located on chromosome 6p21, where the PEBP2alphaA/CBFA1 gene essential for osteogenesis also maps...
  49. ncbi PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
    E Ogawa
    Department of Viral Oncology, Kyoto University, Japan
    Proc Natl Acad Sci U S A 90:6859-63. 1993
    ..The major species of PEBP2 alpha mRNA was expressed in T-cell lines but not in B-cell lines tested. Evidence indicated that PEBP2 functions as a transcriptional activator and is involved in regulation of T-cell-specific gene expression...
  50. ncbi AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization
    D Levanon
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genomics 23:425-32. 1994
    cDNAs corresponding to three human runt domain containing genes, AML1, AML2, and AML3, were isolated and characterized...
  51. ncbi Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia
    B Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 16:307-10. 1997
    ..CCD has been mapped to chromosome 6p21, where CBFA1, a gene encoding OSF2/CBFA1, a transcriptional activator of osteoblast differentiation, has been localized...
  52. ncbi Mutation analysis of core binding factor A1 in patients with cleidocranial dysplasia
    I Quack
    Department of Hematology, University of Freiburg Medical Center, Freiburg, Germany
    Am J Hum Genet 65:1268-78. 1999
    ..We recently demonstrated that mutations in the transcription factor CBFA1, on chromosome 6p21, are associated with CCD...
  53. ncbi CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression
    Soraya Gutierrez
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655 0106, USA
    J Biol Chem 277:1316-23. 2002
    ..element in the proximal promoter of the rat osteocalcin gene, which resides in close proximity to a Runx2 (Cbfa1) element, essential for tissue-specific activation...
  54. ncbi CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia
    G Zhou
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM225, 630E, Houston, TX 77030, USA
    Hum Mol Genet 8:2311-6. 1999
    ..is a dominantly inherited skeletal dysplasia caused by mutations in the osteoblast-specific transcription factor CBFA1. To correlate CBFA1 mutations in different functional domains with the CCD clinical spectrum, we studied 26 ..
  55. ncbi Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein
    Claire K Inman
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Rd, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 25:3182-93. 2005
    The transcription factor Runx2 is essential for the expression of a number of bone-specific genes and is primarily considered a master regulator of bone development...
  56. ncbi AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element
    J Hess
    Deutsches Krebsforschungszentrum Heidelberg, Division of Signal Transduction and Growth Control B0800, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Biol Chem 276:20029-38. 2001
    ..Moreover, c-Fos interacts with the C-terminal part of Cbfa1 and Cbfa2, sharing a conserved transcriptional repression domain...
  57. ncbi Mutations in the RUNX2 gene in patients with cleidocranial dysplasia
    Florian Otto
    Department of Hematology Oncology, University of Freiburg Medical Center, Freiburg, Germany
    Hum Mutat 19:209-16. 2002
    ..The locus for this disease was mapped to chromosome 6p21. RUNX2 is a member of the runt family of transcription factors and its expression is restricted to developing osteoblasts ..
  58. ncbi Histone deacetylase 1-mediated histone modification regulates osteoblast differentiation
    Hyun Woo Lee
    Department of Biological Sciences, Research Center for Functional Cellulomics, Seoul National University, Seoul, Korea
    Mol Endocrinol 20:2432-43. 2006
    ..Consistently, knockdown of HDAC1 by the short interference RNA system stimulated osteoblast differentiation. Taken together, these data propose that down-regulation of HDAC1 is an important process for osteogenesis...
  59. ncbi The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding
    Stefan Bäckström
    Biocrystallography Group, Umeå Centre for Molecular Pathogenesis UCMP, Umea University, SE 901 87 Umea, Sweden
    J Mol Biol 322:259-72. 2002
    ..domain is characteristic of the RUNX family of heterodimeric eukaryotic transcription factors, including RUNX1, RUNX2 and RUNX3...
  60. ncbi Genomic organization, expression of the human CBFA1 gene, and evidence for an alternative splicing event affecting protein function
    V Geoffroy
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Mamm Genome 9:54-7. 1998
    The Cbfa1 gene, which encodes the transcription factor Osf2/Cbfa1 required for osteoblast differentiation in mouse and human, is mutated in cleidocranial dysplasia, a skeletal dysplasia...
  61. ncbi MK-801 neurotoxicity in cupric silver-stained sections: lesion reconstruction by 3-dimensional computer image analysis
    A S Fix
    The Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45253 8707, USA
    Toxicol Pathol 28:84-90. 2000
    ..Using a color charged-couple device (CCD) camera and a macro lens, a series of 2-dimensional images, which encompassed the entire rostral to caudal extent ..
  62. ncbi Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro
    Jorge P Pinto
    CCMAR, University of Algarve, Campus de Gambelas, Faro, Portugal
    J Bone Miner Res 20:1440-53. 2005
    The zebrafish runx2b transcription factor is an ortholog of RUNX2 and is highly conserved at the structural level...
  63. ncbi Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice
    R N D'Souza
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, FIN 00014 University of Helsinki, Finland
    Development 126:2911-20. 1999
    ..Recently, Cbfa1 was shown to be a critical transcriptional regulator of osteoblast differentiation...
  64. ncbi The role of periodontal ligament cells in delayed tooth eruption in patients with cleidocranial dysostosis
    Stefan Lossdörfer
    Department of Orthodontics, University of Bonn, Germany
    J Orofac Orthop 70:495-510. 2009
    The clinical appearance of patients with cleidocranial dysplasia (CCD), which is caused by mutations in the RUNX2 gene, is characterized by anomalies of the clavicles, thorax, spine, pelvis and extremities and by disturbances of the ..
  65. ncbi The significance of RUNX2 in postnatal development of the mandibular condyle
    Birgit Rath-Deschner
    Department of Orthodontics, University of Bonn, Bonn, Germany
    J Orofac Orthop 71:17-31. 2010
    b>RUNX2, in the Runt gene family, is one of the most important transcription factors in the development of the skeletal system...
  66. ncbi Tooth eruption and cementum formation in the Runx2/Cbfa1 heterozygous mouse
    S J Zou
    Department of Oral Cell Biology, ACTA, Van der Boechorststr 7, 1081 BT Amsterdam, The Netherlands
    Arch Oral Biol 48:673-7. 2003
    ..This disorder involves a mutation in the osteoblast-specific transcription factor Runx2/Cbfa1, leading to haploinsufficiency of the Runx2/Cbfa1 protein...
  67. ncbi Mouse clavicular development: analysis of wild-type and cleidocranial dysplasia mutant mice
    L F Huang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Dyn 210:33-40. 1997
    Cleidocranial dysplasia (CCD) is an autosomal dominant disease characterized by hypoplasia or aplasia of clavicles, open fontanelles, and other skeletal anomalies...
  68. ncbi Delayed tooth eruption and suppressed osteoclast number in the eruption pathway of heterozygous Runx2/Cbfa1 knockout mice
    Shuichi Yoda
    Maxillofacial Orthognathics, Department of Maxillofacial Reconstruction and Function, Division of Maxillofacial Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Arch Oral Biol 49:435-42. 2004
    Genetic studies have recently identified a mutation of one allele of runt-related gene 2 (RUNX2/CBFA1) as the cause for an autosomal-dominant skeletal disorder, cleidocranial dysplasia (CCD), which is characterised by hypoplasia of the ..
  69. ncbi CCAAT/Enhancer binding protein beta abrogates retinoic acid-induced osteoblast differentiation via repression of Runx2 transcription
    Nadine Wiper-Bergeron
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Mol Endocrinol 21:2124-35. 2007
    Runx2/CBFA1/AML3 is a master regulator of the osteoblast lineage and has been shown to directly control the transcription of numerous osteoblast-specific genes including alkaline phosphatase, osteopontin, and type I collagen...
  70. ncbi Separation of polyesters by gradient reversed-phase high-performance liquid chromatography on a 1.5 microm non-porous column
    K Rissler
    Consumer Care Analytics, Ciba Specialty Chemicals, Basel, Switzerland
    J Chromatogr A 871:243-58. 2000
    ..not only occurs with respect to molecular weight distribution (MWD) but also to chemical composition distribution (CCD) and functionality type distribution (FTD)...
  71. ncbi The contribution of videostroboscopy in daily ENT practice
    M Remacle
    Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Louvain at Mont-Godinne, Yvoir, Belgium
    Acta Otorhinolaryngol Belg 50:265-81. 1996
    ..The equipment comprises a stroboscope, a CCD type of camera, a video recorder, a microphone, a monitor or television screen and rigid optics and/or a fiberscope...
  72. ncbi Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblastogenesis
    Sylvain Marcellini
    Departamento de Biologia Celular, Facultad de Ciencias Biologicas, Universidad de Concepcion, Casilla 160 C, Concepcion, Chile
    BMC Evol Biol 10:78. 2010
    ..In this study, we focused on the transcriptional regulators Runx2 and VDR (the Vitamin D Receptor) that, in mammals, directly interact together and stabilize complexes of co-..
  73. ncbi A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
    P Ducy
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 13:1025-36. 1999
    ..b>Cbfa1, a transcriptional activator of osteoblast differentiation during embryonic development, is also expressed in ..
  74. ncbi Localization of epithelial sodium channel and aquaporin-2 in rabbit kidney cortex
    J Loffing
    Institute of Anatomy, University of Zurich, CH-8057 Zurich, Switzerland
    Am J Physiol Renal Physiol 278:F530-9. 2000
    ..In rabbit cortex ENaC is restricted to the connecting tubule (CNT) cells and cortical collecting duct (CCD) cells...
  75. ncbi Crossed cerebellar diaschisis demonstrated by (18)F- FDG-PET/CT
    Gunjan Garg
    Division of PET Imaging, MIRC Institute of Nuclear Medicine and Allied Sciences, Delhi 54, India
    Hell J Nucl Med 12:171-2. 2009
    To the Editor: It is important to recognize significant metabolic patterns like crossed cerebellar diaschisis (CCD) in oncology patients undergoing fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)FFDG-..
  76. ncbi Spatial expression of Cbfa1/Runx2 isoforms in teeth and characterization of binding sites in the DSPP gene
    Shuo Chen
    University of Texas Health Science Center at San Antonio, Dental School, Department of Pediatric Dentistry, 7703 Floyd Curl Drive, MC 7888, San Antonio, TX 78229 3900, USA
    Connect Tissue Res 43:338-44. 2002
    ..Recently three Cbfa1/Runx isoforms (Pebp2 alpha A/type I, til-1/type II, and Osf2/type III) have been identified that differ in their amino-terminal sequences...
  77. ncbi Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth
    X P Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, PO Box 56, FIN 00014, University of Helsinki, Finland
    J Dent Res 84:138-43. 2005
    Heterozygous mutations in the RUNX2 (CBFA1) gene cause cleidocranial dysplasia, characterized by multiple supernumerary teeth. This suggests that Runx2 inhibits successional tooth formation...
  78. ncbi Mutational analysis of RUNX2 gene in Chinese patients with cleidocranial dysplasia
    Chenying Zhang
    Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology, 22 Zhongguancun Nandajie, Haidian District, Beijing 100081, China
    Mutagenesis 25:589-94. 2010
    ..inherited skeletal dysplasia caused by mutations in the osteoblast-specific transcription factor-encoding gene, RUNX2. To correlate different RUNX2 mutations with CCD clinical spectrum, we studied six independent Chinese CCD ..
  79. ncbi An assessment of root cementum in cleidocranial dysplasia
    A L Counts
    Department of Orthodontics, University of Oklahoma College of Dentistry, Oklahoma City 73190, USA
    Angle Orthod 71:293-8. 2001
    ..of cellular and acellular cementum on the roots of 2 teeth extracted from a subject with cleidocranial dysplasia (CCD) compared to 10 teeth extracted from 10 subjects unaffected by CCD...
  80. ncbi Phenotypic changes in dentition of Runx2 homozygote-null mutant mice
    Thomas Aberg
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    J Histochem Cytochem 52:131-9. 2004
    Genetic and molecular studies in humans and mice indicate that Runx2 (Cbfa1) is a critical transcriptional regulator of bone and tooth formation...
  81. ncbi Immunocytochemical and immunoelectron microscopic localization of alpha-, beta-, and gamma-ENaC in rat kidney
    H Hager
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 280:F1093-106. 2001
    ..and protein have been localized to the principal cells of the connecting tubule (CNT), cortical collecting duct (CCD), and outer medullary collecting duct (OMCD) in rat kidney...
  82. ncbi The retinoblastoma protein is an essential mediator of osteogenesis that links the p204 protein to the Cbfa1 transcription factor thereby increasing its activity
    Yi Luan
    Department of Orthopedic Surgery, New York University Medical Center, New York, New York 10003, USA
    J Biol Chem 282:16860-70. 2007
    ..the coordinated activity of numerous proteins including the transcription factor core-binding factor alpha1 (Cbfa1). Deregulation of Cbfa1 results in metabolic bone diseases including osteoporosis and osteopetrosis...
  83. ncbi The ecology of malaria--as seen from Earth-observation satellites
    M C Thomson
    Liverpool School of Tropical Medicine
    Ann Trop Med Parasitol 90:243-64. 1996
    ..an analysis of two of these products, normalized difference vegetation index (NVDI) and cold-cloud duration (CCD), is given in conjunction with epidemiological and entomological data from The Gambia, a country where extensive ..
  84. ncbi A Runx2 threshold for the cleidocranial dysplasia phenotype
    Yang Lou
    Department of Cell Biology, Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655 0106, USA
    Hum Mol Genet 18:556-68. 2009
    ..autosomal-dominant skeletal disease that results from mutations in the bone-specific transcription factor RUNX2 (CBFA1/AML3). However, distinct RUNX2 mutations in CCD do not correlate with the severity of the disease...
  85. ncbi [Cleidocranial dysplasia. Description and analysis of a patient cohort]
    U Baumert
    AG Kraniofaziale Genetik Tissue Engineering, BioPark Regensburg, Zentrum für Medizinische Biotechnologie, Josef Engert Strasse 9, 93051 Regensburg, Germany
    Mund Kiefer Gesichtschir 10:385-93. 2006
    ..CCD is possibly the only general syndrome that can be diagnosed based on the dental findings alone. CCD correlates with mutations in the RUNX2 gene.
  86. ncbi Effect of cleidocranial dysplasia-related novel mutation of RUNX2 on characteristics of dental pulp cells and tooth development
    Dongying Xuan
    Department of Periodontology, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, China
    J Cell Biochem 111:1473-81. 2010
    ..dysplasia (CCD) is an autosomal-dominant disorder caused by a lack of function of one or more alleles of the RUNX2 gene...
  87. ncbi Cleidocranial dysplasia: molecular genetic analysis and phenotypic-based description of a Middle European patient group
    Uwe Baumert
    Department of Orthodontics, Center for Craniofacial Genetics, University of Regensburg, Regensburg, Germany
    Am J Med Genet A 139:78-85. 2005
    ..Characteristic features are typical facial and dental appearance plus morphologic anomalies. RUNX2 (OMIM 600211), the responsible gene for CCD, is considered to be a master gene for bone development and bone ..
  88. ncbi Predicting the distribution of tsetse flies in West Africa using temporal Fourier processed meteorological satellite data
    D J Rogers
    Department of Zoology, University of Oxford
    Ann Trop Med Parasitol 90:225-41. 1996
    ..For rainfall the surrogate was the Cold-Cloud-Duration (CCD) index derived from the geostationary, Meteosat satellite series...
  89. ncbi Common polymorphisms rather than rare genetic variants of the Runx2 gene are associated with femoral neck BMD in Spanish women
    Begoña Pineda
    Research Foundation, Hospital Clinico Universitario, Avenida Blasco Ibañez 17, Valencia, Spain
    J Bone Miner Metab 28:696-705. 2010
    b>RUNX2 is a transcription factor essential for osteoblast differentiation and skeletal morphogenesis...
  90. ncbi Deletions of the RUNX2 gene are present in about 10% of individuals with cleidocranial dysplasia
    Claus E Ott
    Institut fur Medizinische Genetik, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    Hum Mutat 31:E1587-93. 2010
    ..Hand malformations are also common. Mutations in RUNX2 cause CCD, but are not identified in all CCD patients...
  91. ncbi Differential expression patterns of Runx2 isoforms in cranial suture morphogenesis
    M H Park
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Taegu, Korea
    J Bone Miner Res 16:885-92. 2001
    b>Runx2 (previously known as Cbfal/Pebp2alphaA/AML3), a key transcription factor in osteoblast differentiation, has at least two different isoforms using alternative promoters, which suggests that the isoforms might be expressed ..
  92. ncbi [Two novel RUNX2 gene mutations in two Chinese families with cleidocranial dysplasia]
    Chao Gao
    Rehabilitation Center, Zhengzhou Children s Hospital, Zhengzhou, Henan, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:140-3. 2010
    To identify the RUNX2 gene mutation in two unrelated Chinese families with cleidocranial dysplasia (CCD), and to assess the feasibility of gene diagnosis for patients with CCD.
  93. ncbi Cbfa1: a molecular switch in osteoblast biology
    P Ducy
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Dyn 219:461-71. 2000
    ..of osteoblast biology has made rapid progress due to the characterization of the function of one molecule, Cbfa1. This member of the runt/Cbfa family of transcription factors was first identified as the nuclear protein binding ..
  94. ncbi Discovery: Osf2/Cbfa1, a master gene of bone formation
    I M Shapiro
    School of Dental Medicine, Department of Biochemistry, University of Pennsylvania, Philadelphia 19104 6003, USA
    Clin Orthod Res 2:42-6. 1999
    ..Recent studies indicate that the transcription factor Osf2 (osteoblast specific transcription factor 2)/Cbfa1 (core binding factor activity 1) serves as a Master Gene regulating osteoblast-specific ..
  95. ncbi Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity
    Eric Hesse
    Department of Medicine, Harvard Medical School, Harvard School of Dental Medicine, Harvard University, Boston, MA 02115, USA
    J Cell Biol 191:1271-83. 2010
    b>Runx2 is indispensable for osteoblast lineage commitment and early differentiation but also blocks osteoblast maturation, thereby causing bone loss in Runx2 transgenic mice. Zinc finger protein 521 (Zfp521) antagonizes Runx2 in vivo...
  96. ncbi Transcriptional regulation of osteoblast differentiation during development
    G Karsenty
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Front Biosci 3:d834-7. 1998
    ..the characterization of OSE2, an osteoblast-specific cis-acting element present in the Osteocalcin promoter Osf2/Cbfa1, the protein that binds to OSE2, was identified...
  97. ncbi Prevalence and clinical relevance of specific immunoglobulin E to pollen caused by sting- induced specific immunoglobulin E to cross-reacting carbohydrate determinants in Hymenoptera venoms
    A M Kochuyt
    Department of Internal Medicine, Division of Allergy and Clinical Immunology, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Exp Allergy 35:441-7. 2005
    ..sIgE to such cross-reacting CD (CCD) are believed to have little or no biological activity and thus may cause misdiagnosis of pollen sensitization ..
  98. ncbi Expression of mouse Coiled-coil-DIX1 (Ccd1), a positive regulator of Wnt signaling, during embryonic development
    Katsunori Soma
    Department of Molecular Neurobiology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8577, Japan
    Gene Expr Patterns 6:325-30. 2006
    ..We have recently identified the Coiled-coil-DIX1 (Ccd1) gene encoding a third type of a DIX domain-containing protein...
  99. ncbi Optical resolution of asymmetric triacylglycerols by chiral-phase high-performance liquid chromatography
    Y Iwasaki
    Laboratory of Molecular Biotechnology, Graduate School of Bio- and Agro-Sciences, Nagoya University, Japan
    J Chromatogr A 905:111-8. 2001
    ..TGs, 1-docosahexaenoyl-2,3-dicapryroyl-sn-glycerol (DCC) and 1,2-dicapryroyl-3-docosahexaenoyl-sn-glycerol (CCD), was achieved with the CHIRALCEL OD column...
  100. ncbi Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2
    Guozhi Xiao
    Department of Periodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    J Biol Chem 277:36181-7. 2002
    ..We showed recently that this pathway is important for activation and phosphorylation of Cbfa1/Runx2, an osteoblast-related transcription factor (Xiao, G., Jiang, D., Thomas, P., Benson, M. D., Guan, K...
  101. ncbi Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells
    Roberto Paredes
    Departamento de Biologia Molecular, Facultad de Ciencias Biologicas, Universidad de Concepcion, Casilla 160 C, Concepcion, Chile
    Mol Cell Biol 24:8847-61. 2004
    Bone-specific transcription of the osteocalcin (OC) gene is regulated principally by the Runx2 transcription factor and is further stimulated in response to 1alpha,25-dihydroxyvitamin D3 via its specific receptor (VDR)...

Research Grants67

  1. Mechanistic Role of NELL-1 in Premature Suture Closure
    Kang Ting; Fiscal Year: 2003
    ..b>CBFA1 has recently been shown to play an important role in FGFR1 induced CS...
  2. TGF-Beta regulation of Runx2 in bone formation and quality
    Tamara Alliston; Fiscal Year: 2007
    ..can result from its activation of the intracellular effector, SmadS, to bind and inhibit the function of Runx2, a critical transcriptional regulator of osteoblast differentiation...
  3. In vivo utilization of Runx2 isoforms during skeletal development
    Julie Liu; Fiscal Year: 2007
    Project Summary: Runx2 is a master regulator of bone formation and has two major isoforms that are functionally similar but are controlled by two distinct promoters (P1 and P2)...
  4. OSF2/CBFAL AND MURINE ODONTOGENESIS
    RENA D SOUZA; Fiscal Year: 2002
    ..Heterozygous mutants in Osf2/Cbfa1 cause cleidocranial dysplasia (CCD), an inherited disorder in humans and mice characterized by skeletal defects...
  5. Sex Steroids and Runx Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2010
    b>Runx2 is a master osteoblast transcription factor playing pivotal roles in skeletal development and homeostasis. In humans, Runx2 haplotypes contribute to variations in bone mass...
  6. Sex Steroids and Runx Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2010
    b>Runx2 is a master osteoblast transcription factor playing pivotal roles in skeletal development and homeostasis. In humans, Runx2 haplotypes contribute to variations in bone mass...
  7. Cellular and Molecular Determinants of Tooth Eruption
    Hitesh Kapadia; Fiscal Year: 2005
    ..The recent discovery that mutations in Cbfa1, a transcription factor, cause a genetic disorder in humans called cleidocranial dysplasia (CCD) has opened up a ..
  8. Expression and Regulation of LEF-1 During Odontogenesis
    Petros Papagerakis; Fiscal Year: 2005
    ..The major research focus of the candidate is to determine the molecular mechanisms by which mutation(s) in the RUNX2 transcription factor cause the tooth and bone phenotypes associated with CCD...
  9. Regulation of Runx2 Function by Twist-1 in Tooth Development
    RENA D SOUZA; Fiscal Year: 2007
    In this competing renewal, we propose to continue our research on the role of Runx2 in tooth development...
  10. Regulation of Runx2 Function by Twist-1 in Tooth Development
    RENA D SOUZA; Fiscal Year: 2009
    In this competing renewal, we propose to continue our research on the role of Runx2 in tooth development...
  11. Regulation of Runx2 Function by Twist-1 in Tooth Development
    RENA D SOUZA; Fiscal Year: 2009
    In this competing renewal, we propose to continue our research on the role of Runx2 in tooth development...
  12. Runx2 and Axin2 Interactions During Bone Formation
    Jennifer J Westendorf; Fiscal Year: 2010
    ..Runx2 (Cbfa1) is a transcription factor required for osteoblastogenesis and chondrocytes hypertrophy...
  13. Identification of CBFA1 Targets in Osteoblasts
    Baruch Frenkel; Fiscal Year: 2003
    b>CBFA1 is a transcription factor with the most well established role in osteoblast differentiation and biomineralization...
  14. Genome-wide ENU mutagenesis screen for Runx2 modifiers
    Patricia Ducy; Fiscal Year: 2006
    ..screen in mice using ethyl-nitrosourea (ENU) mutagenesis to expose mutations able to functionally compensate for Runx2 haploinsufficiency...
  15. REGULATION OF RUNX-2 TRANSCRIPTIONAL ACTIVITY
    JENNIFER WESTENDORF; Fiscal Year: 2005
    ..The transcription factor Runx2 (CBFA1, AML-3) is absolutely required for osteoblast development and Runx2 mutations cause cleidocranial dysplasia (CCD)...
  16. Nell-1, A Cbfa 1 Downstream Target, In Bone Formation
    Kang Ting; Fiscal Year: 2009
    ..data for the parent grant Competitive Renewal demonstrate that: 1) runt-related transcription factor 2 (Runx2) regulates LNell-1 through cis-acting element 2 (OSE2) response elements (REs); 2) LNell-1 increases osteoblastic ..
  17. Identification of the transcriptional regulators of chondrocyte hypertrophy
    ANDREW BRUCE LASSAR; Fiscal Year: 2010
    Work in the Lassar lab has established that forced expression of Runx2 in somites can activate expression of chondrocyte hypertrophy markers (i.e...
  18. MAP KINASE REGULATION OF OSTEOBLAST FUNCTION
    Renny Franceschi; Fiscal Year: 2007
    ..to the nucleus via the ERK/MAPK pathway to phosphorylate and activate the osteoblast-related transcription factor, RUNX2. Other factors such as FGF2, IGF-1 and mechanical stimulation, known to signal through MARK, also stimulate RUNX2 ..
  19. Molecular Signaling in Oxidative Stress-induced Vascular Calcification
    Yabing Chen; Fiscal Year: 2010
    ..bone markers" and downregulation of "VSMC markers", concurrent with increased expression and enhanced activity of Runx2, and the key osteogenic transcription factor...
  20. Molecular Signaling in Oxidative Stress-induced Vascular Calcification
    Yabing Chen; Fiscal Year: 2009
    ..bone markers" and downregulation of "VSMC markers", concurrent with increased expression and enhanced activity of Runx2, and the key osteogenic transcription factor...
  21. Molecular Signaling in Oxidative Stress-induced Vascular Calcification
    Yabing Chen; Fiscal Year: 2009
    ..bone markers" and downregulation of "VSMC markers", concurrent with increased expression and enhanced activity of Runx2, and the key osteogenic transcription factor...
  22. A Dual Resolution Cone Beam CT System for 3-D Breast Imaging
    Chris Shaw; Fiscal Year: 2007
    ..A collimator is added to limit the x-ray field to the VOI and a small field of view CCD detector is used to acquire high resolution projection images for the VOI at an appropriate exposure level...
  23. HOXBOXES, HOMEODOMAINS, AND OSTEOBLAST GENE EXPRESSION
    Dwight Towler; Fiscal Year: 2007
    The transcription factor hierarchy controlling osteoblast gene expression during development is emerging. Runx2 (Cbfal/Osf2) confers osteogenic potential...
  24. Characterization of WWOX, the Cancer Gene Spanning FRA16D
    CLAUDIO MARCELO ALDAZ; Fiscal Year: 2010
    ..Importantly, these genes are controlled by the master regulator of bone formation RUNX2, and RUNX2 becomes overexpressed in breast cancer metastatic cells...
  25. GFI-1 and Osteoblast Suppression in Multiple Myeloma
    GARSON DAVID contact ROODMAN; Fiscal Year: 2010
    ..The OBP from these mice maintained low levels of the critical OB transcription factor, Runx2 even when induced to differentiate and had elevated expression of the transcriptional repressor Gfi-1, which can ..