RUNX2

Summary

Gene Symbol: RUNX2
Description: runt-related transcription factor 2
Alias: AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA, PEA2-alpha A, PEBP2-alpha A, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit, acute myeloid leukemia 3 protein, core-binding factor, runt domain, alpha subunit 1, oncogene AML-3, osteoblast-specific transcription factor 2, polyomavirus enhancer-binding protein 2 alpha A subunit
Species: human

Top Publications

  1. pmc Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein
    Claire K Inman
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Rd, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 25:3182-93. 2005
  2. ncbi Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    P Ducy
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston 77030, USA
    Cell 89:747-54. 1997
  3. pmc Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA
    Sanjeev K Baniwal
    Department Biochemistry and Molecular Biology, Institute of Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Mol Endocrinol 23:1203-14. 2009
  4. ncbi Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    F Otto
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, United Kingdom
    Cell 89:765-71. 1997
  5. ncbi CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression
    Soraya Gutierrez
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655 0106, USA
    J Biol Chem 277:1316-23. 2002
  6. pmc Orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) protein negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation through suppressing runt-related gene 2 (Runx2) activity
    Kkot Nim Lee
    Dental Science Research Institute and the BK21 Project, Medical Research Center for Biomineralization Disorders, School of Dentistry, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 287:18888-99. 2012
  7. pmc Glutamine repeat variants in human RUNX2 associated with decreased femoral neck BMD, broadband ultrasound attenuation and target gene transactivation
    Nigel A Morrison
    School of Medical Sciences, Griffith University, Southport, Australia
    PLoS ONE 7:e42617. 2012
  8. pmc Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness
    Nyam Osor Chimge
    Department of Biochemistry, Institute for Genetic Medicine, USC Epigenome Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Clin Cancer Res 18:901-11. 2012
  9. ncbi AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization
    D Levanon
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genomics 23:425-32. 1994
  10. ncbi Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
    Hideaki Sowa
    Division of Endocrinology Metabolism, Neurology and Hematology Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
    J Biol Chem 279:40267-75. 2004

Detail Information

Publications243 found, 100 shown here

  1. pmc Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein
    Claire K Inman
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Rd, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 25:3182-93. 2005
    The transcription factor Runx2 is essential for the expression of a number of bone-specific genes and is primarily considered a master regulator of bone development...
  2. ncbi Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    P Ducy
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston 77030, USA
    Cell 89:747-54. 1997
    ..We have now cloned the cDNA encoding Osf2/Cbfa1, the protein that binds to OSE2...
  3. pmc Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA
    Sanjeev K Baniwal
    Department Biochemistry and Molecular Biology, Institute of Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Mol Endocrinol 23:1203-14. 2009
    b>Runx2 and androgen receptor (AR) are master transcription factors with pivotal roles in bone metabolism and prostate cancer (PCa)...
  4. ncbi Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    F Otto
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, United Kingdom
    Cell 89:765-71. 1997
    We have generated Cbfa1-deficient mice. Homozygous mutants die of respiratory failure shortly after birth. Analysis of their skeletons revealed an absence of osteoblasts and bone...
  5. ncbi CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression
    Soraya Gutierrez
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655 0106, USA
    J Biol Chem 277:1316-23. 2002
    ..element in the proximal promoter of the rat osteocalcin gene, which resides in close proximity to a Runx2 (Cbfa1) element, essential for tissue-specific activation...
  6. pmc Orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) protein negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation through suppressing runt-related gene 2 (Runx2) activity
    Kkot Nim Lee
    Dental Science Research Institute and the BK21 Project, Medical Research Center for Biomineralization Disorders, School of Dentistry, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 287:18888-99. 2012
    ..Furthermore, the immunoprecipitation assay showed that COUP-TFII and Runx2 physically interacted and COUP-TFII significantly impaired the Runx2-dependent activation of the osteocalcin ..
  7. pmc Glutamine repeat variants in human RUNX2 associated with decreased femoral neck BMD, broadband ultrasound attenuation and target gene transactivation
    Nigel A Morrison
    School of Medical Sciences, Griffith University, Southport, Australia
    PLoS ONE 7:e42617. 2012
    b>RUNX2 is an essential transcription factor required for skeletal development and cartilage formation...
  8. pmc Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness
    Nyam Osor Chimge
    Department of Biochemistry, Institute for Genetic Medicine, USC Epigenome Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Clin Cancer Res 18:901-11. 2012
    To assess the clinical significance of the interaction between estrogen and Runx2 signaling, previously shown in vitro.
  9. ncbi AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization
    D Levanon
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genomics 23:425-32. 1994
    cDNAs corresponding to three human runt domain containing genes, AML1, AML2, and AML3, were isolated and characterized...
  10. ncbi Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
    Hideaki Sowa
    Division of Endocrinology Metabolism, Neurology and Hematology Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
    J Biol Chem 279:40267-75. 2004
    ..DNA (AS) antagonized bone morphogenetic protein (BMP)-2-induced alkaline phosphatase activity and osteocalcin and Runx2 mRNA expression...
  11. ncbi Craniosynostosis-associated gene nell-1 is regulated by runx2
    Thien Truong
    Dental of Craniofacial Research Institute, University of California, Los Angeles, CA 90095, USA
    J Bone Miner Res 22:7-18. 2007
    ..We identitifed three OSE2 elements in the NELL-1 promoter that are directly bound and transactivated by Runx2. Forced expression of Runx2 induces NELL-1 expression in rat calvarial cells.
  12. ncbi Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)
    Brad Sevetson
    Functional Genomics Department, Amgen Corp, Seattle, Washington 98101, USA
    J Biol Chem 279:13849-58. 2004
    ..Cbfa1/RUNX2 is a key transcriptional regulator of osteoblast function...
  13. ncbi ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function
    L Bruhn
    Department of Microbiology, University of California, San Francisco 94143 0414, USA
    Genes Dev 11:640-53. 1997
    ..We propose that ALY mediates context-dependent transcriptional activation by facilitating the functional collaboration of multiple proteins in the TCR alpha enhancer complex...
  14. ncbi Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
    Rick B Vega
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 119:555-66. 2004
    ..chondrocyte hypertrophy and endochondral bone formation by interacting with and inhibiting the activity of Runx2, a transcription factor necessary for chondrocyte hypertrophy...
  15. pmc A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator
    R Yagi
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogo in, Sakyo ku, Kyoto 606 8507, Japan
    EMBO J 18:2551-62. 1999
    ..These results indicate that the PY motif is a novel transcription activation domain that functions by recruiting YAP as a strong transcription activator to target genes...
  16. ncbi The RUNX genes: gain or loss of function in cancer
    Karen Blyth
    Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, G61 1QH, UK
    Nat Rev Cancer 5:376-87. 2005
    ..have such an ambiguous role in cancer? How and where do these genes impinge on the pathways that regulate growth control and differentiation? And what is the evidence for a wider role for the RUNX genes in non-haematopoietic cancers?..
  17. ncbi Bone morphogenetic protein-2 stimulates Runx2 acetylation
    Eun Joo Jeon
    Department of Biochemistry, School of Medicine, and Institute for Tumor Research, Chungbuk National University, Cheongju 361 763, Korea
    J Biol Chem 281:16502-11. 2006
    Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic protein (BMP) pathway...
  18. pmc PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
    E Ogawa
    Department of Viral Oncology, Kyoto University, Japan
    Proc Natl Acad Sci U S A 90:6859-63. 1993
    ..The major species of PEBP2 alpha mRNA was expressed in T-cell lines but not in B-cell lines tested. Evidence indicated that PEBP2 functions as a transcriptional activator and is involved in regulation of T-cell-specific gene expression...
  19. doi Runx2 in human breast carcinoma: its potential roles in cancer progression
    Yoshiaki Onodera
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Cancer Sci 101:2670-5. 2010
    b>Runx2 has been proposed as one of the pivotal factors in the process of osteogenesis and metastasis in human malignancies including breast cancer, but its details have not been evaluated...
  20. pmc Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma
    Saminathan S Nathan
    Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore
    Mol Biol Rep 36:153-8. 2009
    ..Molecular analysis reveals OS1 cells express the pocket protein pRB and the runt-related transcription factor Runx2. Strikingly, Runx2 is expressed at higher levels in OS1 cells than in human fetal osteoblasts...
  21. ncbi Runx2/Smad3 complex negatively regulates TGF-β-induced connective tissue growth factor gene expression in vascular smooth muscle cells
    Yoshiaki Ohyama
    Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Atheroscler Thromb 19:23-35. 2012
    ..We previously showed that Runx2, a key transcription factor in osteoblast differentiation, regulates osteogenic conversion and dedifferentiation ..
  22. doi Inhibition of osteogenic differentiation of human adipose-derived stromal cells by retinoblastoma binding protein 2 repression of RUNX2-activated transcription
    Wenshu Ge
    Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China
    Stem Cells 29:1112-25. 2011
    ..and luciferase reporter experiments suggested that RBP2 was physically and functionally associated with RUNX2, an essential transcription factor that governed osteoblastic differentiation...
  23. pmc Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis
    Sanjeev K Baniwal
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA, USA
    Mol Cancer 9:258. 2010
    ..b>Runx2, an osteoblast master transcription factor, is aberrantly expressed in PCa cells, and promotes their metastatic ..
  24. doi Analysis of HDAC1-mediated regulation of Runx2-induced osteopontin gene expression in C3h10t1/2 cells
    Zhongli Zhang
    Institute of Genetics and Cell Biology, Northeast Normal University, Changchun, 130024, People s Republic of China
    Biotechnol Lett 34:197-203. 2012
    ..We have analyzed the effects of HDAC1 on Runx2-mediated regulation of osteopontin (OPN) promoter activation and gene expression in mesenchymal progenitor C3h10t1/..
  25. doi Runx2 mRNA expression in the tissue, serum, and circulating non-hematopoietic cells of patients with thyroid cancer
    Luca Dalle Carbonare
    Department of Medicine, Clinic of Internal Medicine D, University of Verona, Piazzale Scuro, 10, 37134 Verona, Italy
    J Clin Endocrinol Metab 97:E1249-56. 2012
    b>Runx2, a master gene of osteogenic differentiation, is also expressed in nonosseous cancer cells. Microcalcifications are characteristic of papillary thyroid carcinoma and represent a useful find for diagnosis...
  26. doi Continuous cyclic mechanical tension inhibited Runx2 expression in mesenchymal stem cells through RhoA-ERK1/2 pathway
    Yu Shi
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine SJTUSM, Shanghai, China
    J Cell Physiol 226:2159-69. 2011
    ..We firstly figure out CCMT inhibiting the expression of osteogenic genes such as key transcription factor Runx2. It is known that RhoA regulates cell differentiation in response to mechanical stimuli...
  27. ncbi RUNX2 alleles associated with BMD in Scottish women; interaction of RUNX2 alleles with menopausal status and body mass index
    Tanya Vaughan
    School of Health Science, Griffith University Gold Coast Campus, 4215 Queensland, Australia
    Bone 34:1029-36. 2004
    ..We previously reported the association of the RUNX2 A allele with increased bone mineral density (BMD) and protection against a common form of osteoporotic fracture ..
  28. doi Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptor
    Tomohiko Sase
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Cancer 131:2284-93. 2012
    Runt-related transcription factor 2 (RUNX2) belongs to the RUNX family of heterodimeric transcription factors, and is mainly associated with osteogenesis...
  29. ncbi Alleles of RUNX2/CBFA1 gene are associated with differences in bone mineral density and risk of fracture
    Tanya Vaughan
    Genomics Research Center, School of Health Science, Gold Coast Campus Griffith University, Queensland, Australia
    J Bone Miner Res 17:1527-34. 2002
    The aim of this study was to determine if DNA polymorphism within runt-related gene 2 (RUNX2)/core binding factor A1 (CBFA1) is related to bone mineral density (BMD)...
  30. doi Regulation of RUNX2 transcription factor-DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity
    Karen F Underwood
    the Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA
    J Bone Miner Res 27:913-25. 2012
    ..b>RUNX2 is a DNA-binding transcription factor that regulates target genes important in bone formation, angiogenesis, and ..
  31. pmc Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription
    Daniel J Purcell
    Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, Los Angeles, California 90089 9176, USA
    J Cell Biochem 113:2406-14. 2012
    b>Runx2, best known for its role in regulating osteoblast-specific gene expression, also plays an increasingly recognized role in prostate and breast cancer metastasis...
  32. ncbi PEBP2alphaA/CBFA1 mutations in Japanese cleidocranial dysplasia patients
    Y W Zhang
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto, Japan
    Gene 244:21-8. 2000
    ..deletion, and the other was a missense mutation in the Runt domain which abolished the DNA-binding activity of Runx2/PEBP2alphaA/CBFA1...
  33. doi Family-based association study of polymorphisms in the RUNX2 locus with hand bone length and hand BMD
    S Ermakov
    Human Population Biology Research Unit, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Ann Hum Genet 72:510-8. 2008
    ..to test the hypothesis of association of radiographic hand bone length (BL) and BMD with polymorphisms in the RUNX2 locus. Four SNPs linked to the two RUNX2 promoters were genotyped in 212 nuclear Caucasian families...
  34. doi A novel RUNX2 mutation (T420I) in Chinese patients with cleidocranial dysplasia
    G X Wang
    Department of Paediatrics, Qilu Hospital of Shandong University, Jinan, P R China
    Genet Mol Res 9:41-7. 2010
    ..dysplasia (CCD) is an autosomal-dominant heritable skeletal disease caused by heterozygous mutations in the RUNX2 gene...
  35. pmc Overexpression of runt-related transcription factor-2 is associated with advanced tumor progression and poor prognosis in epithelial ovarian cancer
    Weiping Li
    Department of Gynaecology and Obstetrics, Clinical Section, PLA General Hospital, Beijing 100853, China
    J Biomed Biotechnol 2012:456534. 2012
    ..To investigate clinical significance of runt-related transcription factor (RUNX)-2 in epithelial ovarian cancer (EOC)...
  36. pmc Cadmium-induced decrease in RUNX2 mRNA expression and recovery by the antioxidant N-acetylcysteine (NAC) in the human osteoblast-like cell line, Saos-2
    Spenser S Smith
    Department of Biology, The College of Idaho, 2112 Cleveland Blvd, Caldwell, ID 83605, USA
    Toxicol In Vitro 23:60-6. 2009
    ..In this work, we hypothesize that cadmium exposure induces oxidative stress which leads to decreased RUNX2 mRNA expression and increased apoptotic death, and predict that the antioxidant NAC mitigates the damaging effects ..
  37. doi Common polymorphisms rather than rare genetic variants of the Runx2 gene are associated with femoral neck BMD in Spanish women
    Begoña Pineda
    Research Foundation, Hospital Clinico Universitario, Avenida Blasco Ibañez 17, Valencia, Spain
    J Bone Miner Metab 28:696-705. 2010
    b>RUNX2 is a transcription factor essential for osteoblast differentiation and skeletal morphogenesis...
  38. pmc Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway
    Ya Ling Hsu
    Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    J Biol Chem 286:37335-46. 2011
    ..of lung cancer migration by BMP-2 is associated with increased ERK and p38 activation and the up-regulation of Runx2 and Snail...
  39. ncbi Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation
    Meng Qiao
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA
    J Biol Chem 281:7118-28. 2006
    b>RUNX2 is a member of the runt family of DNA-binding transcription factors. RUNX2 mediates endothelial cell migration and invasion during tumor angiogenesis and is expressed in metastatic breast and prostate tumors...
  40. ncbi Mutations in the RUNX2 gene in patients with cleidocranial dysplasia
    Florian Otto
    Department of Hematology Oncology, University of Freiburg Medical Center, Freiburg, Germany
    Hum Mutat 19:209-16. 2002
    ..The locus for this disease was mapped to chromosome 6p21. RUNX2 is a member of the runt family of transcription factors and its expression is restricted to developing osteoblasts ..
  41. pmc Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions
    J Akech
    The Cancer Center Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, MA, USA
    Oncogene 29:811-21. 2010
    b>Runx2, a bone-specific transcriptional regulator, is abnormally expressed in highly metastatic prostate cancer cells. Here, we identified the functional activities of Runx2 in facilitating tumor growth and osteolysis...
  42. pmc Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 69:6807-14. 2009
    The transcription factor Runx2 is highly expressed in breast cancer cells compared with mammary epithelial cells and contributes to metastasis...
  43. pmc Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter
    Jennifer J Westendorf
    Department of Orthopaedic Surgery University of Minnesota Cancer Center College of Biological Sciences Graduate Program in Microbiology, Immunology, and Cancer Biology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mol Cell Biol 22:7982-92. 2002
    b>Runx2 (Cbfa1, AML-3) is multifunctional transcription factor that is essential for osteoblast development...
  44. ncbi Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease
    George L Barnes
    Department of Orthopaedic Surgery, Boston University Medical Center, Massachusetts 02118, USA
    Cancer Res 64:4506-13. 2004
    ..We demonstrated recently that breast cancer cells express the Runx2 transcription factor, essential for bone formation and a regulator of skeletal homeostasis...
  45. pmc Runx2 protein stabilizes hypoxia-inducible factor-1α through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes
    Sun Hee Lee
    School of Life Sciences and Biotechnology, College of Natural Sciences, Daegu 702 701, South Korea
    J Biol Chem 287:14760-71. 2012
    ..Here, we investigated the cross-talk between HIF-1α and Runt-related transcription factor 2 (Runx2) in the growth plate...
  46. ncbi Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor
    Z S Xiao
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Gene 214:187-97. 1998
    Although the CBFA1 gene encodes an osteoblast-specific transcription factor that regulates osteoblast differentiation, uncertainty exists about the organization of its 5' end and the relevance of a novel N-terminal sequence identified in ..
  47. ncbi Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2
    Shirwin M Pockwinse
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Physiol 206:354-62. 2006
    ..lineages and have been linked to human cancers including acute myelogenous leukemia (RUNX1), as well as breast (RUNX2) and gastric cancers (RUNX3)...
  48. pmc Runx2 regulates survivin expression in prostate cancer cells
    Minyoung Lim
    Programs in Genetic, Molecular and Cellular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Lab Invest 90:222-33. 2010
    ..Here, for the first time, we identify Runx2 as a key regulator of survivin transcription...
  49. pmc Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity
    Jose Sierra
    Departamento de Biologia Molecular, Facultad de Ciencias Biologicas, Universidad de Concepcion, Concepcion, Chile
    Mol Cell Biol 23:3339-51. 2003
    ..In osteoblastic cells, transcription of the bone-specific osteocalcin (OC) gene is principally regulated by the Runx2/Cbfa1 transcription factor and is stimulated in response to vitamin D(3) via the vitamin D(3) receptor complex...
  50. pmc Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility
    Margaretha van der Deen
    Dept of Cell Biology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655 0106, USA
    J Biol Chem 287:4503-17. 2012
    Runt-related transcription factors (RUNX1, RUNX2, and RUNX3) are key lineage-specific regulators of progenitor cell growth and differentiation but also function pathologically as cancer genes that contribute to tumorigenesis...
  51. pmc Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer
    Kakoli Das
    Department of Pathology, National University of Singapore, Singapore
    Eur J Cancer 45:2239-48. 2009
    The runt-related transcription factor, Runx2 may have an oncogenic role in mediating metastatic events in breast cancer, but whether Runx2 has a role in the early phases of breast cancer development is not clear...
  52. doi Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform
    Chee Wai Chua
    Cancer Biology Group, Department of Anatomy and Departments of Pathology and Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Clin Cancer Res 15:4322-35. 2009
    ..In the present study, we aimed to first verify the role of Runx2 in prostate cancer progression and metastasis, and, subsequently, assessed if FTY720 could modulate Runx2 ..
  53. doi Association of a RUNX2 promoter polymorphism with bone mineral density in postmenopausal Korean women
    Hee Jung Lee
    Center for Genome Science, National Institute of Health, 5 Nokbun dong, Eunpyung Gu, Seoul, Republic of Korea
    Calcif Tissue Int 84:439-45. 2009
    ..Bone mineral density (BMD) is a major determinant of bone strength. RUNX2 is an osteoblast-specific transcription factor involved in osteoblast differentiation and ossification...
  54. ncbi Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
    S Mundlos
    Kinderklinik, Klinikum der Johannes Gutenberg Universitat, Mainz, Germany
    Cell 89:773-9. 1997
    ..In some families, the phenotype segregates with deletions resulting in heterozygous loss of CBFA1, a member of the runt family of transcription factors...
  55. pmc Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma
    David M Thomas
    Ian Potter Foundation Centre for Cancer Genomics and Predictive Medicine, and Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Center, Victoria, Melbourne, Australia
    J Cell Biol 167:925-34. 2004
    ..The function of runx2, a master regulator of osteoblast differentiation belonging to the runt family of tumor suppressor genes, is ..
  56. pmc Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo
    Amjad Javed
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 102:1454-9. 2005
    ..We have previously shown that aberrant expression of the Runx2 DNA binding domain in metastatic breast cancer cells can prevent production of osteolytic lesions in bone...
  57. ncbi Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia
    B Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 16:307-10. 1997
    ..CCD has been mapped to chromosome 6p21, where CBFA1, a gene encoding OSF2/CBFA1, a transcriptional activator of osteoblast differentiation, has been localized...
  58. pmc The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion
    Jitesh Pratap
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Mol Cell Biol 25:8581-91. 2005
    The Runx2 (Cbfa1/AML3) transcription factor and matrix metalloproteinase 9 (MMP9) are key regulators of growth plate maturation and bone formation...
  59. pmc Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations
    Taketoshi Yoshida
    Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Am J Hum Genet 71:724-38. 2002
    ..heritable skeletal disease caused by heterozygous mutations in the osteoblast-specific transcription factor RUNX2. We have performed mutational analysis of RUNX2 on 24 unrelated patients with CCD...
  60. pmc Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2
    Daniel W Young
    Department of Cell Biology and Cancer Center, Program in Molecular Medicine, and Information Services, University of Massachusetts Medical School, Worcester, MA 01655 0105, USA
    Proc Natl Acad Sci U S A 104:3189-94. 2007
    ..Here we show that Runx2 protein is stable during cell division and remains associated with chromosomes during mitosis through sequence-..
  61. pmc BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity
    Ji Hae Jun
    Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul 110 749, Republic of Korea
    J Biol Chem 285:36410-9. 2010
    b>Runx2 is a critical transcription factor for osteoblast differentiation. Regulation of Runx2 expression levels and transcriptional activity is important for bone morphogenetic protein (BMP)-induced osteoblast differentiation...
  62. ncbi Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene
    H Drissi
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655 0106, USA
    J Cell Physiol 184:341-50. 2000
    The runt related transcription factor CBFA1 (AML3/PEBP2alphaA/RUNX2) regulates expression of several bone- and cartilage-related genes and is required for bone formation in vivo...
  63. pmc A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia
    Y W Zhang
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 97:10549-54. 2000
    ..autosomal-dominant human bone disease, is thought to be caused by heterozygous mutations in runt-related gene 2 (RUNX2)/polyomavirus enhancer binding protein 2alphaA (PEBP2alphaA)/core-binding factor A1 (CBFA1)...
  64. ncbi Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2
    Daniel W Young
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Nature 445:442-6. 2007
    ..Runt-related transcription factors Runx1, Runx2 and Runx3 establish and maintain cell identity, and convey phenotypic information through successive cell ..
  65. pmc Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy
    Bekim Sadikovic
    Department of Pathology and Molecular Medicine, Richardson Labs, Queen s University, Kingston, K7L 3N6 Canada
    BMC Cancer 10:202. 2010
    ..Recent discoveries have highlighted a potential role of a number of genes including: RECQL4, DOCK5, SPP1, RUNX2, RB1, CDKN1A, P53, IBSP, LSAMP, MYC, TNFRSF1B, BMP2, HISTH2BE, FOS, CCNB1, and CDC5L.
  66. ncbi Promoter 2 -1025 T/C polymorphism in the RUNX2 gene is associated with femoral neck bmd in Spanish postmenopausal women
    Mariona Bustamante
    Department of Genetics, University of Barcelona, Av Diagonal, 645, E 08028, Barcelona, Spain
    Calcif Tissue Int 81:327-32. 2007
    Stimulation of bone formation is a key therapeutic target in osteoporosis. Runx2 is a runt domain transcription factor essential to osteoblast differentiation, bone remodeling, and fracture healing...
  67. ncbi Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter
    J Hanai
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 70 8455, Japan
    J Biol Chem 274:31577-82. 1999
    ..PEBP2 may thus be a nuclear target of TGF-beta/BMP signaling...
  68. pmc Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-β-signaling pathway
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Carcinogenesis 32:318-26. 2011
    ..We evaluated genetic variation in RUNX1 (40 tagSNPs), RUNX2 (19 tagSNPs), RUNX3 (9 tagSNPs), MAPK1 (6 tagSNPs), eIF4E (3 tagSNPs), eIF4EBP2 (2 tagSNP) and eIF4EBP3 (2 tagSNPs)..
  69. pmc Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation
    Run Shen
    Department of Orthopaedics and Department of Pathology, Center for Musculoskeletal Research, University of Rochester, School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 281:3569-76. 2006
    b>Runx2 is a bone-specific transcription factor that plays a critical role in bone development, postnatal bone formation, and chondrocyte maturation. The protein levels of Runx2 are regulated by the ubiquitin-proteasome pathway...
  70. ncbi Association of functionally different RUNX2 P2 promoter alleles with BMD
    James D Doecke
    School of Medical Science, Gold Coast Campus, Griffith University, Queensland, Australia
    J Bone Miner Res 21:265-73. 2006
    b>RUNX2 gene SNPs were genotyped in subjects from the upper and lower deciles of age- and weight-adjusted femoral neck BMD...
  71. doi Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomas
    Dong Feng Niu
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    Lab Invest 92:1181-90. 2012
    Runx2/Cbfa1 is a member of the Runt-related transcription factor family and is an essential regulator of osteoblast/chondrocyte differentiation...
  72. pmc The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells
    Margaretha van der Deen
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 109:828-37. 2010
    Prostate cancer cells often metastasize to bone where osteolytic lesions are formed. Runx2 is an essential transcription factor for bone formation and suppresses cell growth in normal osteoblasts but may function as an oncogenic factor ..
  73. pmc Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites
    Sayyed K Zaidi
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0106, USA
    Proc Natl Acad Sci U S A 99:8048-53. 2002
    ..Thus, Runx-mediated intranuclear targeting of Smads is critical for the integration of two distinct pathways essential for fetal development...
  74. doi RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cells
    Ghali Olfa
    LR2B LBCM EA 2603 IFR 114 Université Lille Nord de France Boulogne sur mer France
    Bone 46:901-10. 2010
    The runt-related transcriptional factor RUNX2 is an essential mediator of the osteoblast phenotype and plays a pivotal role in the process of osteoblast differentiation...
  75. doi Runx2 is expressed in human glioma cells and mediates the expression of galectin-3
    Valentina Vladimirova
    Neuro and Tumor Cell Biology Group, Department of Nuclear Medicine, University of Bonn Medical Center, Bonn, Germany
    J Neurosci Res 86:2450-61. 2008
    b>Runx2 is a member of the Runx family of transcription factors (Runx1-3) with a restricted expression pattern...
  76. pmc Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 68:7795-802. 2008
    b>Runx2, required for bone formation, is ectopically expressed in breast cancer cells...
  77. pmc General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2
    Shibing Yu
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Biol Chem 283:5542-53. 2008
    ..ATF4 knock-out mice have reduced bone mass (severe osteoporosis) throughout life. Runx2 (runt-related transcription factor 2) is a runt domain-containing transcription factor that is essential for bone ..
  78. pmc Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2
    Qing Wang
    Medical College, Nankai University, Tianjin 300071, China
    J Biol Chem 282:10742-8. 2007
    ..A -2006/+45 Smad6 promoter-luciferase construct was generated along with deletions and Runx2 binding site mutations to examine the role of Smad1 and Runx2 signaling following BMP-2 stimulation in osteoblasts...
  79. ncbi Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3
    Dallas C Jones
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 312:1223-7. 2006
    ..Shn3 was found to control protein levels of Runx2, the principal transcriptional regulator of osteoblast differentiation, by promoting its degradation through ..
  80. doi Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells
    Naoyuki Makita
    Research Institute for Biological Sciences, Tokyo University of Science, Chiba, Japan
    Gene 413:8-17. 2008
    b>Runx2 is a Runt domain transcription factor that transcriptionally regulates osteoblast differentiation and bone formation...
  81. pmc Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms
    Hee Jun Wee
    Department of Viral Oncology, Kyoto University, Japan
    EMBO Rep 3:967-74. 2002
    ..Here, we report a novel observation that suggests that the osteogenesis-associated homologue RUNX2 is negatively regulated by the phosphorylation of two conserved serines (S104 and S451) in two distinct functional ..
  82. ncbi N- and E-cadherin mediate early human calvaria osteoblast differentiation promoted by bone morphogenetic protein-2
    E Hay
    INSERM U 349, Affiliated CNRS, Cell and Molecular Biology of Bone and Cartilage, Paris, France
    J Cell Physiol 183:117-28. 2000
    ..increased messenger RNA levels for alkaline phosphatase (ALP), the osteoblast specific transcription factor Osf2/Cbfa1 and osteocalcin, and enhanced in vitro osteogenesis in long-term culture...
  83. ncbi AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element
    J Hess
    Deutsches Krebsforschungszentrum Heidelberg, Division of Signal Transduction and Growth Control B0800, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Biol Chem 276:20029-38. 2001
    ..Moreover, c-Fos interacts with the C-terminal part of Cbfa1 and Cbfa2, sharing a conserved transcriptional repression domain...
  84. ncbi AML3/CBFalpha1 is required for androgen-specific activation of the enhancer of the mouse sex-limited protein (Slp) gene
    Y M Ning
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0618, USA
    J Biol Chem 274:30624-30. 1999
    ..by a high affinity binding site specific for AML/CBFalpha and was specifically supershifted by an antibody to AML3/CBFalpha1, placing factor B within the AML3/CBFalpha1 subclass...
  85. ncbi RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region
    Marcie Fowler
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 711130, USA
    J Cell Biochem 97:1-17. 2006
    The RUNX transcription factors (RUNX1, RUNX2, and RUNX3) play essential roles in hematopoiesis and skeletal development...
  86. ncbi Prostate cancer expression of runt-domain transcription factor Runx2, a key regulator of osteoblast differentiation and function
    Kristen D Brubaker
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Prostate 56:13-22. 2003
    ..Specific transcription factors, including Runx2, regulate the expression of many bone-related factors in osteoblasts...
  87. ncbi Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway
    Meng Qiao
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, USA
    J Biol Chem 279:42709-18. 2004
    ..b>RUNX2, a member of the Ig-loop family of transcription factors is expressed in vascular endothelial cells (EC) and ..
  88. pmc BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype
    Mattabhorn Phimphilai
    Department of Biological Chemistry, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 1078, USA
    J Bone Miner Res 21:637-46. 2006
    b>RUNX2 expression in mesenchymal cells induces osteoblast differentiation and bone formation...
  89. ncbi CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia
    G Zhou
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM225, 630E, Houston, TX 77030, USA
    Hum Mol Genet 8:2311-6. 1999
    ..is a dominantly inherited skeletal dysplasia caused by mutations in the osteoblast-specific transcription factor CBFA1. To correlate CBFA1 mutations in different functional domains with the CCD clinical spectrum, we studied 26 ..
  90. pmc RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors
    He Yu Zhang
    Department of Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Endocrine 35:101-11. 2009
    ..Two binding sites for RUNX1 and one binding site for RUNX2 were identified in the LGALS3 promoter region...
  91. ncbi Identification of novel CBFA1/RUNX2 mutations causing cleidocranial dysplasia
    C Bergwitz
    Abteilung für Klinische Endokrinologie, Hochschule Hannover, Germany
    J Inherit Metab Dis 24:648-56. 2001
    Core binding factor A1 (CBFA1/RUNX2) is a runt-like transcription factor essential for osteoblast differentiation...
  92. ncbi Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2
    Marie Bertrand-Philippe
    Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Biol Chem 279:24530-9. 2004
    ..In this study we identify RUNX1 and RUNX2 as UTE-1-binding proteins that are induced at the post-transcriptional level during activation of HSC...
  93. ncbi Runx2 phosphorylation induced by fibroblast growth factor-2/protein kinase C pathways
    Byung Gyu Kim
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Jung Gu, Daegu, Korea
    Proteomics 6:1166-74. 2006
    b>Runx2 is a key transcription factor in osteoblast differentiation, and its activity is regulated by fibroblast growth factors (FGFs)...
  94. ncbi Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation
    Richard C D'Alonzo
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 277:816-22. 2002
    ..Here we show that Cbfa1 and c-Fos.c-Jun appear to cooperatively bind the RD- and AP-1-binding sites and form ternary structures in vitro...
  95. pmc Mutation analysis of core binding factor A1 in patients with cleidocranial dysplasia
    I Quack
    Department of Hematology, University of Freiburg Medical Center, Freiburg, Germany
    Am J Hum Genet 65:1268-78. 1999
    ..We recently demonstrated that mutations in the transcription factor CBFA1, on chromosome 6p21, are associated with CCD...
  96. ncbi Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression
    Virginie Lamour
    Metastasis Research Laboratory, Center of Experimental Cancer Research and Bone and Cartilage Metabolism Research Unit, University of Liege, 4000 Liege, Belgium
    J Biol Chem 282:36240-9. 2007
    ..human osteosarcoma cells and in differentiating normal human osteoblasts, concomitantly with the decrease of Runx2, a key transcription factor controlling bone formation...
  97. ncbi Six novel mutations of the RUNX2 gene in Italian patients with cleidocranial dysplasia
    Alessandra Tessa
    Molecular Medicine and Genetics, IRCCS Bambino Gesù, Rome, Italy
    Hum Mutat 22:104. 2003
    ..We identified ten heterozygous base changes in the RUNX2 gene, including six novel mutations [c.522insA, c.389G>A (W130X), c.662T>G (V221G), IVS2+T>A, c...
  98. ncbi Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter
    Rachel A Kahler
    University of Minnesota Cancer Center, Department of Orthopaedic Surgery and Graduate Program in Microbiology, Immunology and Cancer Biology, Minneapolis, Minnesota 55455, USA
    J Biol Chem 278:11937-44. 2003
    Functional control of the transcription factor Runx2 is crucial for normal bone formation. Runx2 is detectable throughout osteoblast development and maturation and temporally regulates several bone-specific genes...
  99. doi Expression and function of Cbfa-1/Runx2 in thyroid papillary carcinoma cells
    Toyoshi Endo
    Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo City, Yamanashi, Japan
    J Clin Endocrinol Metab 93:2409-12. 2008
    ..Development of calcifying foci is a common finding in human thyroid papillary carcinoma, but its mechanisms remain unknown...
  100. ncbi Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells
    George L Barnes
    Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Cancer Res 63:2631-7. 2003
    ..Our results demonstrate that Runx2 is ectopically expressed in breast cancer cells and that one isoform of Runx2 can activate bsp expression in these ..
  101. ncbi The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding
    Stefan Bäckström
    Biocrystallography Group, Umeå Centre for Molecular Pathogenesis UCMP, Umea University, SE 901 87 Umea, Sweden
    J Mol Biol 322:259-72. 2002
    ..domain is characteristic of the RUNX family of heterodimeric eukaryotic transcription factors, including RUNX1, RUNX2 and RUNX3...

Research Grants78

  1. The Insulin/IGF-I Axis in Diabetic Osteopathy
    John L Fowlkes; Fiscal Year: 2013
    ..in mouse models of T1D;2) normalization of systemic insulin levels stimulates new bone formation through RUNX2 and RUNX2 target genes in diabetic animals;and 3) insulin and IGF-I may signal via similar down-stream pathways to ..
  2. Novel Mechanism of PTH Effects on Bone Metabolism
    Bin Wang; Fiscal Year: 2013
    ..Other proteins, such as, regulator of G protein signaling 2 (RGS2), runt-related transcription factor 2 (Runx2), and b-catenin, the activities of which can be induced by PTH and involved in osteogenesis, are also down ..
  3. Osteoblast and Odontoblast Specific Regulatory Action of Runx2 for Bone and Tooth
    MITRA D ADHAMI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Runx2 is a critical component of skeletal development. Global knock-out studies have proven the role of Runx2 as a regulator for skeletal and tooth development...
  4. Regulation of Osteoblast Differentiation by Delta FosB
    ROLAND E BARON; Fiscal Year: 2012
    ..machinery since all interactions we have identified are with transcription factors or co-factors (Juns, Runx2, C/EBPb, Smad6 and Zfp521, a novel key player in the regulation of BF)...
  5. Regulation of Craniofacial Skeletal Development by Jab1
    Guang Zhou; Fiscal Year: 2010
    ..We have recently identified transcriptional cofactor Jab1 as a novel interacting protein for Runx2, a mater regulator for skeletogenesis...
  6. Sp7 Mediated Control of Runx2 Function for Osteoblast Differentiation
    Amjad Javed; Fiscal Year: 2013
    ..b>Runx2 is an essential transcription factor for chondrocyte and osteoblast differentiation...
  7. Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
    Christopher H Evans; Fiscal Year: 2010
    ..The identities of any human cells within the healed bone will be further probed using antibodies against human Runx2, to identify human osteoblasts, and against human tartrate-resistant acid phosphatase, to identify human ..
  8. Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zipper
    Xing Ming Shi; Fiscal Year: 2012
    ..Based on recent evidence that 1) PPAR(2 inhibits Runx2/Cbfa1 expression and osteoblast differentiation;2) PPAR( agonists induce bone loss and marrow adiposity;and 3) ..
  9. SYNTHESIS OF OSTEOCALCIN IN BONE
    Jane B Lian; Fiscal Year: 2013
    ..Hoxa10 and Dlx3 are bound to the OC gene prior to Runx2 and increase again with Runx2 binding...
  10. Osteoprotective Activity of a Dried Plum Extract
    Brenda J Smith; Fiscal Year: 2012
    ..up-regulate osteoblast differentiation and activity and inhibit osteoclastogenesis simultaneously by up-regulating Runx2 and down-regulating RANKL...
  11. Runx Proteins and Sex Steroid Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2009
    ..b>Runx2 is a master osteoblast transcription factor playing pivotal roles in skeletal development and homeostasis...
  12. Sex Steroids and Runx Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Runx2 is a master osteoblast transcription factor playing pivotal roles in skeletal development and homeostasis. In humans, Runx2 haplotypes contribute to variations in bone mass...
  13. GFI-1 and Osteoblast Suppression in Multiple Myeloma
    GARSON DAVID ROODMAN; Fiscal Year: 2013
    ..The OBP from these mice maintained low levels of the critical OB transcription factor, Runx2 even when induced to differentiate and had elevated expression of the transcriptional repressor Gfi-1, which can ..
  14. BMP2 Gene Regulation in Calcific Aortic Valve Disease
    Melissa B Rogers; Fiscal Year: 2013
    ..One region includes a conserved bone enhancer that binds the master bone differentiation transcription factor RUNX2 and other potential regulators...
  15. The Mechanistic Control of Bone Matrix Material Properties by TGF-beta and Runx2
    TAMARA N ALLISTON; Fiscal Year: 2013
    ..gene expression and differentiation, as well as bone matrix material properties, by repressing the function of Runx2, a key osteoblast transcription factor...
  16. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..First, insulin suppresses the Runx2 inhibitor Twist2, which promotes osteoblast differentiation necessary for normal bone formation...
  17. Role of Zfp521 in bone formation and anabolic responses
    ROLAND E BARON; Fiscal Year: 2013
    ..Furthermore Zfp521 binds Runx2 and Ebf1 and repress their transcriptional activity as well as that of CREB on the Rankl promoter, repressing OB-..
  18. Mechanism &Function of Subnuclear Targeting of Transcription Factors in Bone
    Gary S Stein; Fiscal Year: 2011
    ..Our program initially identified Runx2 as the osteoblast-specific nuclear matrix protein NMP2...
  19. Cranial suture formation in the zebrafish
    Shannon Fisher; Fiscal Year: 2012
    ..the fact that haploinsufficiency for TWIST1 leads to craniosynostosis, and for the transcription factor RUNX2 to delayed and incomplete suture closure, demonstrates that the processes of skull and suture formation are ..
  20. MOLECULAR CONTROL OF RANKL GENE EXPRESSION
    CHARLES A O'BRIEN; Fiscal Year: 2012
    ..DCR knockout mice have reduced RANKL expression and increased bone mass and strength. The transcription factor Runx2 binds to the DCR, suggesting a linkage to osteoblast differentiation;however, stimulation of RANKL was not altered ..
  21. Role of ATF-4 in the Anabolic Actions of PTH on Bone
    Guozhi Xiao; Fiscal Year: 2011
    ..Our hypotheses are: i) PTH activates ATF4 by promoting its phosphorylation and protein-protein interactions with Runx2, and ii) ATF4 mediates the anabolic actions of PTH on bone...
  22. CONTROL OF OSTEOBLAST PROLIFERATION AND DIFFERENTIATION
    Gary S Stein; Fiscal Year: 2013
    ..We identified Runx2 as a transcription factor essential for osteogenic differentiation that integrates developmental signaling ..
  23. Heparanase regulation of osteolysis in multiple myeloma.
    Yang Yang; Fiscal Year: 2013
    ..the first time, that heparanase significantly elevates the expression of RANKL, MMP-9, and transcription factor Runx2 in myeloma cells. In addition, heparanase increases RANKL and decreases OPG expression in osteoblast precursors...
  24. Runx2 and Axin2 Interactions During Bone Formation
    Elizabeth W Bradley; Fiscal Year: 2012
    ..Runx2 (Cbfa1) is a transcription factor required for osteoblastogenesis and chondrocyte hypertrophy...
  25. Evaluation of Recombinant Human Lactoferrin as an Osteogenic Biomaterial
    Ashley A Amini; Fiscal Year: 2013
    ..Additionally, osteocalcin, osteopontin and Runx2, alkaline phosphatase expression levels will be assessed to study the effects of the rhLF gel on cell ..
  26. Mechanistic Role of NELL-1 in Premature Suture Closure
    Kang Ting; Fiscal Year: 2003
    ..b>CBFA1 has recently been shown to play an important role in FGFR1 induced CS...
  27. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
    ..1,25(OH)2D3-VDR modulates osteoblast development/bone formation by impacting the Wnt/LRP5/p-catenin and BMP/SMAD/Runx2 signal cascades, and possibly limits bone overmineralization by controlling a newly recognized phosphate ..
  28. Molecular Signaling in Oxidative Stress-induced Vascular Calcification
    Yabing Chen; Fiscal Year: 2013
    ..bone markers" and downregulation of "VSMC markers", concurrent with increased expression and enhanced activity of Runx2, and the key osteogenic transcription factor...
  29. MAP KINASE REGULATION OF OSTEOBLAST FUNCTION
    RENNY THEODORE FRANCESCHI; Fiscal Year: 2013
    ..P-ERK1/2 translocates to the nucleus and binds chromatin of osteoblast target genes via specific docking sites on Runx2. ii) By phosphorylating RUNX2 on specific sites, kinases initiate chromatin remodeling and transcription;the ..
  30. Defining the molecular mechanisms underlying human RPE plasticity
    Sally Temple; Fiscal Year: 2013
    ..Preliminary studies show dramatic upregulation of the essential osteogenic transcription factor Runx2 in RPE undergoing transformation towards bone...
  31. Nuclear Events in PTH Action on Bone
    Nicola C Partridge; Fiscal Year: 2013
    ..under basal conditions, the MMP-13 gene is repressed by the presence of histone deacetylase- 4 (HDAC4) bound to Runx2 at the runt domain binding site (RD at -132/-126 of the MMP-13 promoter)...
  32. LMP and Bone Healing
    Paul D Robbins; Fiscal Year: 2012
    ..to examine the pathways through which the minimal, domains in LMP are able to induce osteogenesis (BMP signaling, RunX2/OSX transcription and/or MAP kinase) and to examine the ability of the LMP-1 and LMP-3-derived domains to induce ..
  33. Calcification and Vascular Cell Differentiation
    Cecilia M Giachelli; Fiscal Year: 2013
    ..models, the lineage reprogramming of SMCs towards an osteochondrogenic was preceded by de novo expression of Runx2 (also known as Cbfa1), a transcription factor required for normal bone and cartilage development...
  34. Histone Deacetylation Regulates Growth Plate Development
    Lei Wei; Fiscal Year: 2013
    ..whether: 2a) caspases degrade HDAC4;2b) p38 MAPK regulates expression or activity of capsases 2 and 3;2c) Runx2 expression is dependent on p38 MAPK by in situ hybridization in p38 MAPK defective and constitutively activated ..
  35. Relationship between Hdac3 suppression and Wnt signaling in osteoblasts
    Meghan McGee-Lawrence; Fiscal Year: 2011
    ..Hdac3 is expressed in osteoblasts and binds to Runx2 to regulate osteoblastic gene expression, thus playing an important role in bone development and maintenance...
  36. SINGLE SUTURE CRANIOSYNOSTOSIS: CANDIDATE GENE AND PATHWAY DISCOVERY
    Michael L Cunningham; Fiscal Year: 2013
    ..candidate gene resequencing and comparative genome hybridization TWIST1 loss-of-function mutations and IGF1R and RUNX2 gain-of-function mutations have been identified...
  37. Regulation of apoptosis in osteoblasts by Runx2 and NFkB
    Roman Eliseev; Fiscal Year: 2013
    ..goal of this proposal is to expand our previous findings on counter-regulation of apoptosis in osteoblasts (OB) by Runx2 and NF-kB that will serve as preliminary data for our future RO1 project...
  38. Osteosarcoma Translational Research
    Qiping Zheng; Fiscal Year: 2013
    ..publishing data from the principal investigator's group have shown that transgenic mice overexpressing Runx2 or P63 in hypertrophic chondrocytes result in delayed or accelerate chondrocyte maturation respectively...
  39. Regulation of Runx2 Function by Twist-1 in Tooth Development
    RENA D SOUZA; Fiscal Year: 2009
    In this competing renewal, we propose to continue our research on the role of Runx2 in tooth development...
  40. Regulation of Osteoblast Differentiation and Function by Connexin 43
    Joseph P Stains; Fiscal Year: 2013
    ..and activation of signal transduction cascades that converge upon the master regulators of osteoblastogenesis, Runx2 and Osterix. This grant has two specific aims to address this hypothesis...
  41. Elucidating the Relationship Between Notch and WNT Signaling in Bone Formation
    COURTNEY MICHAEL KARNER; Fiscal Year: 2013
    ..has not been defined, although our preliminary studies indicate that Notch likely impedes further progression of Runx2- positive cells...
  42. Bone Cell Growth Regulation by Runx2/Cbfa1
    Andre J Van Wijnen; Fiscal Year: 2013
    ..Our hypothesis is based on a robust set of preliminary data showing that the osteogenic master regulator Runx2 is controlled by mitotic miRs in osteoblastic cell lines...
  43. Structure/Function of CBFbeta
    NANCY ASMUSSEN SPECK; Fiscal Year: 2012
    ..CBFs) are a small family of transcription factors that consist of a DNA binding subunit encoded by the Runx1, Runx2, or Runx3 genes, and a common non-DNA binding CBF2 subunit encoded by the Cbfb gene...
  44. Biophysical regulation of bone remodeling
    JANET E RUBIN; Fiscal Year: 2013
    ..early cluster consisting of canonical Wnt responders followed by a late cluster of anabolic genes, represented by Runx2, osterix (Osx) and eNOS...
  45. CLEIDOCRANIAL DYSPLASIA DENTAL PHENOTYPE AND GENOTYPE CORRELATIONS
    David K Crossman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): RUNX2 is a critical master transcription factor for bone formation. RUNX2 mutations are associated with the human autosomal dominant (AD) disease cleidocranial dysplasia (CCD, OMIM #119600)...
  46. Runx2 and Axin2 Interactions During Bone Formation
    Jennifer J Westendorf; Fiscal Year: 2013
    ..regulators of craniofacial development, bone repair/regeneration, and optimal bone mass accrual and maintenance: Runx2 and Axin2. Runx2 (Cbfa1) is a transcription factor required for osteoblastogenesis and chondrocytes hypertrophy...
  47. Studies of Chondroyte Maturation
    Cristina C Teixeira; Fiscal Year: 2010
    ..of this proposal is that NO regulates chondrocyte maturation by activating cGMP-dependent kinase II and inducing Runx2 activation...
  48. Mesenchymal Regulation of Osteogenesis
    Richard A Schneider; Fiscal Year: 2013
    ..of the Transforming Growth Factor-Beta (TGF[unreadable]) and Bone Morphogenetic Protein (BMP) pathways such as Runx2, Dlx5, and Msx1, since they are known to affect osteogenesis and their expression is altered in chimeras...
  49. Embryonic stem cell-derived osteoprogenitor cells for bone formation and repair
    Ross A Kopher; Fiscal Year: 2010
    ..will be advanced by developing hESC lines engineered to express fluorescent reporter molecules driven by the RUNX2 promoter to facilitate the identification of key signaling and developmental pathways that mediate the development ..
  50. Determination of the role of CBP and p300 mediated Wnt signaling on colonic cells
    Michael Bordonaro; Fiscal Year: 2010
    ..and progression, utilizing CRC cell line model systems of initiation and progression: the normal colon cell lines CCD-841CoN, the adenoma line LT97, the primary colon carcinoma cell line SW480, and the lymph node metastasis cell line ..
  51. TGF-Beta regulation of Runx2 in bone formation and quality
    Tamara Alliston; Fiscal Year: 2007
    ..can result from its activation of the intracellular effector, SmadS, to bind and inhibit the function of Runx2, a critical transcriptional regulator of osteoblast differentiation...
  52. PKC delta as a central mediator of osteogenic signaling
    ATUM BUO; Fiscal Year: 2013
    ..Our lab has shown that PKC[unreadable] regulates the Runx2 activity, one of the master regulators of osteogenesis, thereby presenting a possible mechanism by which PKC[..
  53. Effects of Vascular Runx 2 deletion on osteogenesis and calcification in vessels
    Koba A Lomashvili; Fiscal Year: 2013
    ..Osteogenic differentiation in VSMC has emerged as a potential pathogenetic mechanism for UVC during last decade. Runx2 is the master gene for osteogenic program and without it VSMC cannot undergo osteochondrogenesis...
  54. Inflammatory Control of Periodontal Regeneration
    Lyndon F Cooper; Fiscal Year: 2011
    ..stem-like and osteoblastic cell lines will be used to define how inflammatory stimuli affect a) Smad signaling, b) RUNX2 transactivation and c) LRP5 signal transduction...
  55. Action of Anabolic Factors on Bone Formation in Mice
    MARJA MARIE HURLEY; Fiscal Year: 2013
    ..progenitor cell differentiation towards adipogenesis and this is mediated through regulation of PPARg by Runx2 and Wnt 10b downstream effects...
  56. Identification of the transcriptional regulators of chondrocyte hypertrophy
    ANDREW BRUCE LASSAR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Work in the Lassar lab has established that forced expression of Runx2 in somites can activate expression of chondrocyte hypertrophy markers (i.e...
  57. Nuclear ryanodine receptor type 1: Role in skeletal muscle physiology and disease
    Viktor Yarotskyy; Fiscal Year: 2013
    ..debilitating and life-threatening myopathies, including malignant hyperthermia (MH) and central core disease (CCD). The molecular mechanisms underlying CCD core formation have yet to be fully clarified...
  58. Stem/progenitor cells of the chondrocyte and osteoblast lineage in vivo
    Noriaki Ono; Fiscal Year: 2013
    ..osteoblast lineage Osteoblast differentiation of "mesenchymal stem cells" is regulated by transcription factors Runx2 and Osterix (Osx) expressed early after commitment to the osteoblast lineage...
  59. Defining Common Molecular Parameters For Onset and Progression of Osteoarthritis
    Roland Wolkowicz; Fiscal Year: 2010
    ..Among these are NF-B, Runx2, ESE-1/Elf3, GADD452, and DDR2, each of which impact on the expression of MMP-13, the major collagen-degrading ..
  60. Nell-1, A Cbfa 1 Downstream Target, In Bone Formation
    Kang Ting; Fiscal Year: 2009
    ..data for the parent grant Competitive Renewal demonstrate that: 1) runt-related transcription factor 2 (Runx2) regulates LNell-1 through cis-acting element 2 (OSE2) response elements (REs);2) LNell-1 increases osteoblastic ..
  61. ESE 1 a novel transcriptional regulator of cartilage remodeling
    MARY GOLDRING; Fiscal Year: 2009
    ..a key collagen-degrading enzyme in OA, by binding to ETS/PEA3 sites in the MMP13 promoter and cooperating with Runx2 and AP-1...
  62. The role of Core Binding Factors (CBFs) in the periovulatory process
    Misung Jo; Fiscal Year: 2011
    ..CBF is composed of two subunits;DNA binding alpha-subunit encoded by one of Runx1, Runx2, and Runx3 genes and non-DNA binding beta-subunit, CBF2...
  63. Basic Mechanisms of Human Calcific Aortic Valve Disease
    Gordon S Huggins; Fiscal Year: 2013
    ..previously demonstrated that the retinoblastoma protein (pRb) and CDK pathway regulate bone formation through the runx2 transcription factor and by regulating cellular responses to Notch1...
  64. SGK Regulation of Epithelial Sodium Transport
    David Pearce; Fiscal Year: 2013
    ..2: Characterize the functional effects of mTOR and SGK1 on ENaC in cultured cortical collecting duct (CCD) cells...
  65. Cellular and Molecular Determinants of Tooth Eruption
    Hitesh Kapadia; Fiscal Year: 2005
    ..The recent discovery that mutations in Cbfa1, a transcription factor, cause a genetic disorder in humans called cleidocranial dysplasia (CCD) has opened up a ..
  66. Expression and Regulation of LEF-1 During Odontogenesis
    Petros Papagerakis; Fiscal Year: 2005
    ..The major research focus of the candidate is to determine the molecular mechanisms by which mutation(s) in the RUNX2 transcription factor cause the tooth and bone phenotypes associated with CCD...
  67. Novel Molecular Therapies of Prostate Cancer
    Dario C Altieri; Fiscal Year: 2013
    ..mediated by a{v}B{6} integrin, and Project 3 (Stein and Lian) will elucidate the mechanistic requirements of Runx2-dependent gene expression in metastatic prostate cancer to the bone...
  68. In vivo utilization of Runx2 isoforms during skeletal development
    Julie Liu; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Project Summary: Runx2 is a master regulator of bone formation and has two major isoforms that are functionally similar but are controlled by two distinct promoters (P1 and P2)...
  69. Genome-wide ENU mutagenesis screen for Runx2 modifiers
    Patricia Ducy; Fiscal Year: 2006
    ..screen in mice using ethyl-nitrosourea (ENU) mutagenesis to expose mutations able to functionally compensate for Runx2 haploinsufficiency...
  70. Identification of CBFA1 Targets in Osteoblasts
    Baruch Frenkel; Fiscal Year: 2003
    b>CBFA1 is a transcription factor with the most well established role in osteoblast differentiation and biomineralization...
  71. Membrane Trafficking of Renal Ion Transport Proteins in Potassium Homeostasis
    Chou Long Huang; Fiscal Year: 2013
    ..K+ secretion will also be studied by in vitro microperfusion of isolated CCD tubules. Surgical adrenalectomy will be performed to examine interactions between aldosterone and WNK1 pathway...
  72. Holography-based Photoacoustic Imaging of the Retina
    PARAG VIJAY CHITNIS; Fiscal Year: 2013
    ..Because the proposed holographic implementation of PAI employs a continuous-wave laser and CCD-based full-field interferometry for detecting the photoacoustic (PA) signal, it potentially can acquire 3D-image ..
  73. Molecular, immunological, and clinical dissection of STAT1 hypermorphic mutations
    Steven M Holland; Fiscal Year: 2013
    ..AD) IL-17F deficiencies paved the way for the identification of germ line mutations in the coiled-coil domain (CCD) of STAT1 in AD CMCD kindreds...
  74. MAP KINASE REGULATION OF OSTEOBLAST FUNCTION
    Renny Franceschi; Fiscal Year: 2007
    ..to the nucleus via the ERK/MAPK pathway to phosphorylate and activate the osteoblast-related transcription factor, RUNX2. Other factors such as FGF2, IGF-1 and mechanical stimulation, known to signal through MARK, also stimulate RUNX2 ..
  75. A Dual Resolution Cone Beam CT System for 3-D Breast Imaging
    Chris Shaw; Fiscal Year: 2007
    ..A collimator is added to limit the x-ray field to the VOI and a small field of view CCD detector is used to acquire high resolution projection images for the VOI at an appropriate exposure level...
  76. A Dual Resolution Cone Beam CT System for 3-D Breast Imaging
    Chris C Shaw; Fiscal Year: 2010
    ..A collimator is added to limit the x-ray field to the VOI and a small field of view CCD detector is used to acquire high resolution projection images for the VOI at an appropriate exposure level...
  77. HOXBOXES, HOMEODOMAINS, AND OSTEOBLAST GENE EXPRESSION
    Dwight Towler; Fiscal Year: 2007
    ..b>Runx2 (Cbfal/Osf2) confers osteogenic potential...
  78. Bright and Fast Sensor for Time Resolved X-Ray Diffraction Studies
    VIVEK V NAGARKAR; Fiscal Year: 2010
    ..a tradeoff between spatial resolution and efficiency, and significantly limit the performance of these powerful new CCD devices...