Gene Symbol: RTP4
Description: receptor transporter protein 4
Alias: IFRG28, Z3CXXC4, receptor-transporting protein 4, 28 kDa interferon-responsive protein, 28kD interferon responsive protein, 3CxxC-type zinc finger protein 4, receptor (chemosensory) transporter protein 4, zinc finger, 3CxxC-type 4
Species: human
Products:     RTP4

Top Publications

  1. Wroblewska A, Dhainaut M, Ben Zvi B, Rose S, Park E, Amir E, et al. Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens. Cell. 2018;175:1141-1155.e16 pubmed publisher
    ..Pro-Code/CRISPR screens found two interferon-stimulated genes, the immunoproteasome component Psmb8 and a chaperone Rtp4, are important for antigen-dependent immune editing of cancer cells and identified Socs1 as a negative regulator of ..
  2. Fujita W, Yokote M, Gomes I, Gupta A, Ueda H, Devi L. Regulation of an Opioid Receptor Chaperone Protein, RTP4, by Morphine. Mol Pharmacol. 2019;95:11-19 pubmed publisher
    ..Among the four RTPs, we detected selective and region-specific changes in RTP4 expression; RTP4 mRNA is significantly upregulated in the hypothalamus compared with other brain regions...
  3. Dang W, Xu L, Yin Y, Chen S, Wang W, Hakim M, et al. IRF-1, RIG-I and MDA5 display potent antiviral activities against norovirus coordinately induced by different types of interferons. Antiviral Res. 2018;155:48-59 pubmed publisher
    ..By profiling a subset of important human ISGs using an overexpression approach, we have identified RTP4 and HPSE as moderate anti-norovirus ISGs, whereas IRF-1, RIG-I (also known as DDX58) and MDA5 (also known as IFIH1) ..
  4. Kose M, Kaya M, Aydilek N, Kucukaslan I, Bayril T, Bademkiran S, et al. Expression profile of interferon tau-stimulated genes in ovine peripheral blood leukocytes during embryonic death. Theriogenology. 2016;85:1161-6 pubmed publisher
    ..Compared with that on Day 0, receptor transporter protein 4 (RTP4) and ISG15 expression was upregulated on Day 15 and remained high until Day 21 in both groups, and RTP4 and ISG15 ..
  5. Fricke P, Carvalho P, Lucy M, Curran F, Herlihy M, Waters S, et al. Effect of manipulating progesterone before timed artificial insemination on reproductive and endocrine parameters in seasonal-calving, pasture-based Holstein-Friesian cows. J Dairy Sci. 2016;99:6780-6792 pubmed publisher
    ..genes ISG15, MX1, MX2, and OAS1 were greater for Low P4 than for High P4 cows, whereas relative mRNA levels of RTP4 were greater for High P4 than for Low P4 cows 18 d after TAI...
  6. Sinedino L, Honda P, Souza L, Lock A, Boland M, Staples C, et al. Effects of supplementation with docosahexaenoic acid on reproduction of dairy cows. Reproduction. 2017;153:707-723 pubmed publisher
    ..Pregnant cows fed algae had greater expression of RTP4 in blood leukocytes compared with those in pregnant control cows...
  7. Saito H, Kubota M, Roberts R, Chi Q, Matsunami H. RTP family members induce functional expression of mammalian odorant receptors. Cell. 2004;119:679-91 pubmed
    ..We have used this approach to identify active odorant ligands for ORs, providing a platform for screening the chemical selectivity of the large OR family. ..
  8. Clark A, Metherell L, Cheetham M, Huebner A. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. Trends Endocrinol Metab. 2005;16:451-7 pubmed
    ..Molecular defects underlying other causes of ACTH insensitivity syndromes will probably contribute further to our understanding of these pathways. ..
  9. Behrens M, Bartelt J, Reichling C, Winnig M, Kuhn C, Meyerhof W. Members of RTP and REEP gene families influence functional bitter taste receptor expression. J Biol Chem. 2006;281:20650-9 pubmed
    ..The coimmunoprecipitation of hTAS2R16 and RTP3 or RTP4 suggests that the mechanism by which these cofactors influence hTAS2R16 function might involve direct protein-..

More Information


  1. Stewart J, Mercadante V, Dias N, Canisso I, Yau P, Imai B, et al. Nerve Growth Factor-Beta, purified from bull seminal plasma, enhances corpus luteum formation and conceptus development in Bos taurus cows. Theriogenology. 2018;106:30-38 pubmed publisher
    ..Expression of interferon-stimulated genes (ISG15, MX1, MX2, RTP4) were assessed in peripheral blood leukocytes on day 19...
  2. Nair S, Abraham R, Sundaram S, Sreekumar E. Interferon regulated gene (IRG) expression-signature in a mouse model of chikungunya virus neurovirulence. J Neurovirol. 2017;23:886-902 pubmed publisher
    ..The highly modulated IRGs included Ifit1, Ifi44, Ddx60, Usp18, Stat1, Rtp4, Mnda, Gbp3, Gbp4, Gbp7, Oasl2, Oas1g, Ly6a, Igtp, and Gbp10, along with many others exhibiting lesser changes in ..
  3. Klymenko T, Gu Q, Herbert I, Stevenson A, Iliev V, Watkins G, et al. RNA-Seq Analysis of Differentiated Keratinocytes Reveals a Massive Response to Late Events during Human Papillomavirus 16 Infection, Including Loss of Epithelial Barrier Function. J Virol. 2017;91: pubmed publisher
    ..regulator IRF1, kappa interferon (IFN-κ), and viral restriction factors (IFIT1, -2, -3, and -5, OASL, CD74, and RTP4) were upregulated...