RTN4R

Summary

Gene Symbol: RTN4R
Description: reticulon 4 receptor
Alias: NGR, NOGOR, reticulon-4 receptor, Nogo-66 receptor, UNQ330/PRO526, nogo receptor
Species: human
Products:     RTN4R

Top Publications

  1. He X, Bazan J, McDermott G, Park J, Wang K, Tessier Lavigne M, et al. Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron. 2003;38:177-85 pubmed
    ..Recent studies suggest that an axon surface protein, the Nogo receptor (NgR), may play a role in this process through an unprecedented degree of crossreactivity with myelin-..
  2. Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J, et al. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci. 2004;7:221-8 pubmed
    ..This effect on neurons was mimicked using an exogenously added human LINGO-1-Fc fusion protein. Together these observations suggest that LINGO-1 has an important role in CNS biology. ..
  3. Pool M, Niino M, Rambaldi I, Robson K, Bar Or A, Fournier A. Myelin regulates immune cell adhesion and motility. Exp Neurol. 2009;217:371-7 pubmed publisher
    ..We conclude that NgR1 alters the motility of immune cells exposed to myelin and may thus impact their behaviour within the CNS, particularly under conditions when immune cell activation is heightened. ..
  4. Liu B, Fournier A, GrandPre T, Strittmatter S. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science. 2002;297:1190-3 pubmed
    ..The receptor for Nogo (NgR) has been identified as an axonal glycosyl-phosphatidyl-inositol (GPI)-anchored protein, whereas the MAG receptor ..
  5. Park J, Yiu G, Kaneko S, Wang J, Chang J, He X, et al. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron. 2005;45:345-51 pubmed
    ..which signal through a common receptor complex on neurons consisting of the ligand-binding Nogo-66 receptor (NgR) and two transmembrane coreceptors, p75 and LINGO-1...
  6. Shao Z, Browning J, Lee X, Scott M, Shulga Morskaya S, Allaire N, et al. TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron. 2005;45:353-9 pubmed
    Myelin-associated inhibitory factors (MAIFs) are inhibitors of CNS axonal regeneration following injury. The Nogo receptor complex, composed of the Nogo-66 receptor 1 (NgR1), neurotrophin p75 receptor (p75), and LINGO-1, represses axon ..
  7. Fournier A, GrandPre T, Strittmatter S. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature. 2001;409:341-6 pubmed
    ..Nogo-66 receptor expression is sufficient to impart Nogo-66 axonal inhibition to unresponsive neurons. Disruption of the interaction between Nogo-66 and its receptor provides the potential for enhanced recovery after human CNS injury. ..
  8. Wang K, Kim J, Sivasankaran R, Segal R, He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature. 2002;420:74-8 pubmed
    ..myelin glycoprotein (OMgp) and myelin-associated glycoprotein (MAG), exert their effects through the same Nogo receptor (NgR)...
  9. Meng J, Shi Y, Zhao X, Guo S, Wang H, Zheng Y, et al. No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. J Neural Transm (Vienna). 2007;114:249-54 pubmed
    The RTN4R gene is located in the 22q11 region and it encodes a subunit of the receptor complex (RTN4R-p75NTR) which results in neuronal growth inhibitory signals in response to Nogo-66, MAG or OMG signaling...

More Information

Publications116 found, 100 shown here

  1. Domeniconi M, Cao Z, Spencer T, Sivasankaran R, Wang K, Nikulina E, et al. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron. 2002;35:283-90 pubmed
    ..While a GPI-linked receptor for Nogo (NgR) has been identified, MAG's receptor is unknown. We show that MAG inhibits regeneration by interaction with NgR...
  2. Barton W, Liu B, Tzvetkova D, Jeffrey P, Fournier A, Sah D, et al. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. EMBO J. 2003;22:3291-302 pubmed
    ..that contain a common ligand-binding glycosylphosphatidylinositol-anchored subunit termed the Nogo-66 receptor (NgR)...
  3. Zhang L, Zheng S, Wu H, Wu Y, Liu S, Fan M, et al. Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor. J Neurosci. 2009;29:6348-52 pubmed publisher
    ..We hypothesize that BLyS may be a negative regulator for neuronal functions. Here Nogo-66 receptor (NgR) is identified as a high affinity receptor for BLyS, which inhibits dorsal root ganglion outgrowth in culture...
  4. Thomas R, Favell K, Morante Redolat J, Pool M, Kent C, Wright M, et al. LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition. J Neurosci. 2010;30:6607-12 pubmed publisher
    ..We show that LGI1 mediates this effect by functioning as a specific Nogo receptor 1 (NgR1) ligand that antagonizes the action of myelin-based inhibitory cues...
  5. Yamashita T, Tohyama M. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat Neurosci. 2003;6:461-7 pubmed
    ..This peptide has potential as a therapeutic agent against the inhibitory cues that block regeneration in the central nervous system. ..
  6. Wang K, Koprivica V, Kim J, Sivasankaran R, Guo Y, Neve R, et al. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature. 2002;417:941-4 pubmed
    ..mechanisms that mediate this inhibitory activity of OMgp, we screened an expression library and identified the Nogo receptor (NgR) as a high-affinity OMgp-binding protein...
  7. Sinibaldi L, De Luca A, Bellacchio E, Conti E, Pasini A, Paloscia C, et al. Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia. Hum Mutat. 2004;24:534-5 pubmed
    ..2 aploinsufficiency. We evaluated the Nogo-66 receptor gene (RTN4R), which maps within the DGS/VCFS critical region, as a potential candidate for schizophrenia susceptibility...
  8. Siddiq M, Hannila S, Carmel J, Bryson J, Hou J, Nikulina E, et al. Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System. J Biol Chem. 2015;290:16343-56 pubmed publisher
    ..All three inhibitors can interact with either the Nogo receptor complex or paired immunoglobulin-like receptor B...
  9. Kurihara Y, Saito Y, Takei K. Blockade of chondroitin sulfate proteoglycans-induced axonal growth inhibition by LOTUS. Neuroscience. 2017;356:265-274 pubmed publisher
    ..CSPGs have recently been identified as functional ligands for Nogo receptor-1 (NgR1), which is the common receptor for Nogo proteins, myelin-associated glycoprotein (MAG), ..
  10. Li Q, Cheng Y, Bi M, Kang H, Qu Y, Lin H, et al. Effects of N-Butylphthalide on the expressions of Nogo/NgR in rat brain tissue after carbon monoxide poisoning. Environ Toxicol Pharmacol. 2015;39:953-61 pubmed publisher
    ..The expressions of neurite outgrowth inhibitor (Nogo), myelin-associated glycoprotein (MAG) and Nogo receptor-1 (NgR1) were observed in rat brain tissue by immunohistochemistry and double immunofluorescence staining...
  11. Zhou Q, Wang L, Wang X, Xiong Q, Wei Y, Dang S, et al. [Effect of neuregulin-1 on heart function and inflammatory mediators in rats with sepsis]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018;30:140-144 pubmed publisher
    ..Rats in NRG-1 pre-treatment group (NRG group) were intravenously injected with recombinant human NGR-1 (rhNRG-1) at the dose of 10 μg/kg through tail vein; rats in CLP group and sham group were treated with the same ..
  12. Kan Q, Zhang H, Zhang Y, Li X, Xu Y, Thomé R, et al. Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis. Mol Neurobiol. 2017;54:8404-8418 pubmed publisher
    ..MAT treatment significantly reduced the levels of NogoA, its receptor complex NgR/p75NTR/LINGO-1, and their downstream RhoA/ROCK signaling pathway in the CNS...
  13. Lam H, McMullin R, Nguyen H, Coleman I, Gormley M, Gulati R, et al. Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived Xenografts. Clin Cancer Res. 2017;23:2301-2312 pubmed publisher
    ..LuCaP 136CR displayed reduced androgen receptor (AR) signaling and sustainably low nuclear glucocorticoid receptor (nGR) localization, accompanied by steroid metabolism alteration and epithelial-mesenchymal transition phenotype ..
  14. Shi N, Li Y, Zhang Y, Shen N, Qi L, Wang S, et al. Intelligent "Peptide-Gathering Mechanical Arm" Tames Wild "Trojan-Horse" Peptides for the Controlled Delivery of Cancer Nanotherapeutics. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..The peptide NGR, serving as a cell-targeting peptide for anchoring, and peptide PLGLAG, serving as a substrate peptide for ..
  15. Hua W, Wu H, Zhou M, Liu W, Zhu J, Gu Y, et al. [Protective effects of recombinant human erythropoietin on oligodendrocyte after cerebral infarction]. Zhonghua Bing Li Xue Za Zhi. 2015;44:323-8 pubmed
    ..human erythropoietin (RhEPO) on the expression of oligodendrocyte in the neuron glia antigen 2(NG2), Nogo receptor-interacting protein 1(LINGO-1), myelin basic protein (MBP) and myelin associated glycoprotein (MAG), and to ..
  16. Saghazadeh A, Rezaei N. The role of timing in the treatment of spinal cord injury. Biomed Pharmacother. 2017;92:128-139 pubmed publisher
    ..They function via NgR-dependent mechanisms...
  17. Palandri A, Salvador V, Wojnacki J, Vivinetto A, Schnaar R, Lopez P. Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathways. Cell Death Dis. 2015;6:e1876 pubmed publisher
    ..Also, our results highlight the relevance of the nurture/protective effects of myelin on neurons. ..
  18. Li M, Zhang Y, Zou H, Ouyang J, Zhan Y, Yang L, et al. Investigation of Ginkgo biloba extract (EGb 761) promotes neurovascular restoration and axonal remodeling after embolic stroke in rat using magnetic resonance imaging and histopathological analysis. Biomed Pharmacother. 2018;103:989-1001 pubmed publisher
    ..kinase B (AKT)/ glycogen synthase kinase-3β (GSK-3β)/ collapsin response mediator protein 2 (CRMP2) and NogoA/NgR were detected by Western blotting analysis...
  19. Guo W, Qu W, Zeng L, Qi Z, Huang C, Zhu Z, et al. l-Theanine and NEP1-40 promote nerve regeneration and functional recovery after brachial plexus root avulsion. Biochem Biophys Res Commun. 2018;: pubmed publisher
    ..Possible mechanisms underlying these results are alleviation of oxidative damage and inflammatory responses in the injured area and antagonism of myelin inhibition. ..
  20. Galvez Contreras A, Campos Ordonez T, Lopez Virgen V, Gomez Plascencia J, Ramos Zúñiga R, Gonzalez Perez O. Growth factors as clinical biomarkers of prognosis and diagnosis in psychiatric disorders. Cytokine Growth Factor Rev. 2016;32:85-96 pubmed publisher
    ..epidermal growth factor (EGF), fibroblast growth factor (FGF), Insulin-like growth factor (IGF-1), neuroregulin-1 (NGR-1), erythropoietin (EPO), vascular growth factor (VEGF), transforming growth factor beta (TGF-?), nerve growth ..
  21. Nan L, Yang L, Zheng Y, He Y, Xie Q, Chen Z, et al. Effects of Gualou Guizhi Decoction Aqueous Extract on Axonal Regeneration in Organotypic Cortical Slice Culture after Oxygen-Glucose Deprivation. Evid Based Complement Alternat Med. 2017;2017:5170538 pubmed publisher
    ..protein-43; and decreased protein and mRNA expression of neurite outgrowth inhibitor protein-A (Nogo-A), Nogo receptor 1 (NgR1), ras homolog gene family A (RhoA), rho-associated coiled-coil-containing protein kinase (ROCK), and ..
  22. Zhang C, Bai G, Zhu W, Bai D, Bi G. Identification of miRNA-mRNA Network Associated with Acute Myeloid Leukemia Survival. Med Sci Monit. 2017;23:4705-4714 pubmed
    ..For target-genes of miRNAs, GTSF1, RTN4R, and CD44 were the top risk factor target-genes associated with AML survival...
  23. Wang L, Yu C, Wang J, Leung P, Ma D, Zhao H, et al. Nogo-B is the major form of Nogo at the floor plate and likely mediates crossing of commissural axons in the mouse spinal cord. J Comp Neurol. 2017;525:2915-2928 pubmed publisher
    ..In explant cultures of embryonic day (E) 11 and E12 spinal cord, blocking of NgR function with antagonist peptide NEP1-40 reduced the crossing of newly arrived commissural axons, resulting in an ..
  24. Shen S, Berry G, Castellanos Rivera R, Cheung R, Troupes A, Brown S, et al. Functional analysis of the putative integrin recognition motif on adeno-associated virus 9. J Biol Chem. 2015;290:1496-504 pubmed publisher
    Adeno-associated viruses (AAVs) display a highly conserved NGR motif on the capsid surface...
  25. Fink K, Strittmatter S, Cafferty W. Comprehensive Corticospinal Labeling with mu-crystallin Transgene Reveals Axon Regeneration after Spinal Cord Trauma in ngr1-/- Mice. J Neurosci. 2015;35:15403-18 pubmed publisher
    ..Using crym-GFP, we reevaluated the CST in mice lacking nogo receptor 1 (NgR1), a protein implicated in limiting neural repair...
  26. Pang L, Xia Y, Wang D, Meng X. Antitumor activity of iNGR-GRIM-19 in colorectal cancer. Jpn J Clin Oncol. 2017;47:795-808 pubmed publisher
    ..To explore the antitumor activity of internalizing NGR (iNGR) gene associated with GRIM-19 in colorectal cancer...
  27. Chang C, Niu Z, Gu N, Zhao W, Wang G, Jia Y, et al. Analysis of the ways and methods of signaling pathways in regulating cell cycle of NIH3T3 at transcriptional level. BMC Cell Biol. 2015;16:25 pubmed publisher
    ..Newfound genes such as PKC, RAS, PP2A, NGR and PI3K etc...
  28. Karlsson T, Karlén A, Olson L, Josephson A. Neuronal overexpression of Nogo receptor 1 in APPswe/PSEN1(?E9) mice impairs spatial cognition tasks without influencing plaque formation. J Alzheimers Dis. 2013;33:145-55 pubmed publisher
    ..To further address this issue in vivo, we crossed mice that overexpress Nogo receptor 1 (NgR1), "MemoFlex", in forebrain neurons, with plaque forming APPswe/PSEN1(?E9) mice, to ..
  29. Huang N, Cheng S, Zhang X, Tian Q, Pi J, Tang J, et al. Efficacy of NGR peptide-modified PEGylated quantum dots for crossing the blood-brain barrier and targeted fluorescence imaging of glioma and tumor vasculature. Nanomedicine. 2017;13:83-93 pubmed publisher
    ..circulation, CdSe/ZnS quantum dots (QDs)-based nanoscale and fluorescence, asparagines-glycine-arginine peptides (NGR)-based specific CD13 recognition were integrated to design and synthesize a novel nanoprobe by conjugating ..
  30. Kroksveen A, Guldbrandsen A, Vaudel M, Lereim R, Barsnes H, Myhr K, et al. In-Depth Cerebrospinal Fluid Quantitative Proteome and Deglycoproteome Analysis: Presenting a Comprehensive Picture of Pathways and Processes Affected by Multiple Sclerosis. J Proteome Res. 2017;16:179-194 pubmed publisher
    ..Both are ligands to the nogo receptor, and the glycosylation of these proteins appears to be affected by RRMS...
  31. Zhang Z, Jiang J, Luan M, Ma Z, Gao F, Yu S. Nogo-A antibody treatment enhances neuron recovery after sciatic nerve transection in rats. Eur Rev Med Pharmacol Sci. 2017;21:1780-1786 pubmed
    ..The present study aimed to investigate the signaling pathway of p75 neurotrophin receptor (NTR) and Nogo receptor (NgR) in a sciatic nerve transection (SNT) rat model and evaluate the underlining mechanisms...
  32. Stefan N, Staiger H, Wagner R, Machann J, Schick F, Häring H, et al. A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes. Diabetologia. 2015;58:2877-84 pubmed publisher
    ..reversal of prediabetes (impaired glucose tolerance and/or impaired fasting glucose) to normal glucose regulation (NGR) during a lifestyle intervention is strongly associated with a higher incidence of diabetes later in life...
  33. Theotokis P, Grigoriadis N. p75NTR and TROY: Uncharted Roles of Nogo Receptor Complex in Experimental Autoimmune Encephalomyelitis. Mol Neurobiol. 2018;55:6329-6336 pubmed publisher
    ..the role of neurotrophin receptor p75 (p75NTR) and TROY in disease progression, other key players of the Nogo receptor complex...
  34. Barbariga M, Curnis F, Andolfo A, Zanardi A, Lazzaro M, Conti A, et al. Ceruloplasmin functional changes in Parkinson's disease-cerebrospinal fluid. Mol Neurodegener. 2015;10:59 pubmed publisher
    ..showed that ceruloplasmin is modified by oxidation in vivo, and, in addition, in vitro by deamidation of specific NGR-motifs that foster the gain of integrin-binding function...
  35. Tomas Roig J, Wirths O, Salinas Riester G, Havemann Reinecke U. The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte Differentiation In Vitro and Neuroprotection During the Cuprizone-Induced Central Nervous System Demyelination. CNS Neurosci Ther. 2016;22:387-95 pubmed publisher
    ..2 confers more myelinated axons, increased the expression of retinoid X receptor alpha, and declined nogo receptor expression...
  36. Ding S, Bao Y, Shen J, Gao G, Pan Y, Luo Q, et al. Improved neurite outgrowth on central nervous system myelin substrate by siRNA-mediated knockdown of Nogo receptor. Chin J Traumatol. 2016;19:16-24 pubmed
    To investigate the in vitro effect of short interfering RNAs (siRNAs) against Nogo receptor (NgR) on neurite outgrowth under an inhibitory substrate of central nervous system (CNS) myelin...
  37. Zelenay V, Arzt M, Bibow S, Schwab M, Riek R. The Neurite Outgrowth Inhibitory Nogo-A-?20 Region Is an Intrinsically Disordered Segment Harbouring Three Stretches with Helical Propensity. PLoS ONE. 2016;11:e0161813 pubmed publisher
    ..individual receptor complexes, centred around sphingosine 1-phosphate receptor 2 (S1PR2) for Nogo-A-?20 and Nogo receptor 1 (NgR1) for Nogo-66...
  38. Illathvalappil R, Dhavale V, Bhange S, Kurungot S. Nitrogen-doped graphene anchored with mixed growth patterns of CuPt alloy nanoparticles as a highly efficient and durable electrocatalyst for the oxygen reduction reaction in an alkaline medium. Nanoscale. 2017;9:9009-9017 pubmed publisher
    ..with trigonal bipyramidal and truncated cube-type mixed morphologies, anchored on the nitrogen-doped graphene (NGr) surface (CuPt-TBTC/NGr), was prepared by a simple and fast method...
  39. He J, Han P, Zhang Y, Liu Y, Song S, Feng G, et al. Overexpression of Nogo receptor 3 (NgR3) correlates with poor prognosis and contributes to the migration of epithelial cells of nasopharyngeal carcinoma patients. J Mol Med (Berl). 2018;96:265-279 pubmed publisher
    ..Among these genes, Nogo receptor 3 (NgR3), which was originally identified in the nervous system and plays a role in nerve development and ..
  40. Yeh B, Li W, Li C, Kang W, Huang C, Hour T, et al. Histone deacetylase inhibitor trichostatin A resensitizes gemcitabine resistant urothelial carcinoma cells via suppression of TG-interacting factor. Toxicol Appl Pharmacol. 2016;290:98-106 pubmed publisher
    ..TGIF in gemcitabine resistance were conducted by analyzing NTUB1 cells and their gemcitabine-resistant subline, NGR cells...
  41. Lee J, Kim M, Li L, Velumian A, Aui P, Fehlings M, et al. Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system. Sci Rep. 2017;7:8958 pubmed publisher
    ..b>Nogo receptor 1 (NgR1) has been suggested to govern axonal damage during the progression of disease in the MS-like mouse ..
  42. Raiker S, Lee H, Baldwin K, Duan Y, Shrager P, Giger R. Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity. J Neurosci. 2010;30:12432-45 pubmed publisher
    ..Nogo and OMgp complex with the neuronal cell surface receptors Nogo receptor-1 (NgR1) and paired Ig-like receptor-B (PirB) to regulate neuronal morphology...
  43. Bhagat S, Butler S, Taylor J, McEwen B, Strittmatter S. Erasure of fear memories is prevented by Nogo Receptor 1 in adulthood. Mol Psychiatry. 2016;21:1281-9 pubmed publisher
    ..We examined whether Nogo Receptor 1 (NgR1) regulates the plasticity associated with fear extinction...
  44. Kirikoshi R, Manabe N, Takahashi O. Succinimide Formation from an NGR-Containing Cyclic Peptide: Computational Evidence for Catalytic Roles of Phosphate Buffer and the Arginine Side Chain. Int J Mol Sci. 2017;18: pubmed publisher
    The Asn-Gly-Arg (NGR) motif and its deamidation product isoAsp-Gly-Arg (isoDGR) have recently attracted considerable attention as tumor-targeting ligands...
  45. Sun J, Ren Q, Xu L, Zhang Z. LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in experimental autoimmune encephalomyelitis mice. Sci Rep. 2015;5:14235 pubmed publisher
    ..LINGO-1 (LRR and Ig domain containing NOGO receptor interacting protein 1) has been identified as an inhibitor of oligodendrocyte differentiation and myelination...
  46. Gu Z, Chang M, Fan Y, Shi Y, Lin G. NGR-modified pH-sensitive liposomes for controlled release and tumor target delivery of docetaxel. Colloids Surf B Biointerfaces. 2017;160:395-405 pubmed publisher
    ..this study, a pH-sensitive liposome was constructed containing CHEMS-anchored PEG2000 for extended circulation and NGR peptide as the targeting moiety...
  47. Mert I, Kumar A, Sheedy S, Weaver A, McGree M, Kim B, et al. Clinical significance of enlarged cardiophrenic lymph nodes in advanced ovarian cancer: Implications for survival. Gynecol Oncol. 2018;148:68-73 pubmed publisher
    ..Of the 253 patients (mean age 64.0years), 136 had no gross residual disease (NGR) and 117 had RD. By the QAS definition, CPLNs were abnormal in 28 (11.1%) patients and removed in one case...
  48. Al Halabiah H, Delezoide A, Cardona A, Moalic J, Simonneau M. Expression pattern of NOGO and NgR genes during human development. Gene Expr Patterns. 2005;5:561-8 pubmed
    ..We investigated the expression of the genes encoding Nogo and its receptor, NgR, between weeks eight and 23 of human embryonic development, by quantitative radioactive in situ hybridization...
  49. Jiang D, Du X, Chen D, Zhou L, Chen W, Li Y, et al. One-pot hydrothermal route to fabricate nitrogen doped graphene/Ag-TiO2: Efficient charge separation, and high-performance "on-off-on" switch system based photoelectrochemical biosensing. Biosens Bioelectron. 2016;83:149-55 pubmed publisher
    ..designed novel nanocomposites consisting of TiO2 nanocrystals, Ag nanoparticles (NPs) and nitrogen doped graphene (NGR) via a facile one-pot hydrothermal route...
  50. Wu S, Huang H, Feng X, Du C, Song W. Facile visual colorimetric sensor based on iron carbide nanoparticles encapsulated in porous nitrogen-rich graphene. Talanta. 2017;167:385-391 pubmed publisher
    ..Fe-MOF), small Fe3C nanoparticles were in-situ decorated in 3D porous network of N-rich graphene (NGr)...
  51. Ying K, Chen Z, Dang C, Sun M, Yan G, Kan B, et al. Clinicopathology and Survival in Patients with Gastroesophageal Reflux After Radical Surgery of Proximal Gastric Cancer. Dig Dis Sci. 2018;63:1035-1042 pubmed publisher
    ..The PGC patient cohort was retrospectively grouped as follows: postoperative patients with and without GR (NGR). Clinicopathological characteristics and survival data were compared between the two groups...
  52. GrandPre T, Li S, Strittmatter S. Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature. 2002;417:547-51 pubmed
    ..expressed on the surface of oligodendrocytes and can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR)...
  53. Stephany C, Frantz M, McGee A. Multiple Roles for Nogo Receptor 1 in Visual System Plasticity. Neuroscientist. 2016;22:653-666 pubmed
    ..Here we explore potential mechanisms for NgR1 function in relation to manipulations that reactivate visual plasticity in adults and propose lines of investigation to address relevant gaps in knowledge. ..
  54. Yang Y, Yang Y, Xie X, Xu X, Xia X, Wang H, et al. Dual stimulus of hyperthermia and intracellular redox environment triggered release of siRNA for tumor-specific therapy. Int J Pharm. 2016;506:158-73 pubmed publisher
    ..redox environment, we devised a thermosensitive liposome (TSL) containing an Asparagine-Glycine-Arginine (NGR) peptide and reducible siRNA-CPPs for tumor-specific siRNA transfection (siRNA-CPPs/NGR-TSL), in which siRNA-CPPs ..
  55. Jin S, Ryu H, Li S, Li C, Lim S, Jang W, et al. Nogo-A inhibits the migration and invasion of human malignant glioma U87MG cells. Oncol Rep. 2016;35:3395-402 pubmed publisher
    ..of Nogo-A, Nogo-66, has neurite growth inhibitory activity that is specific for neurons and is mediated by the Nogo receptor. However, most of its functions are not known yet...
  56. Teusch N, Kiefer C. A high-content screening assay for the Nogo receptor based on cellular Rho activation. Assay Drug Dev Technol. 2006;4:133-41 pubmed
    ..With respect to the neuronal Nogo receptor (NgR), recent data assign a key role for the GTPase Rho in the control of cellular responses leading to actin ..
  57. Budel S, Padukkavidana T, Liu B, Feng Z, Hu F, Johnson S, et al. Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. J Neurosci. 2008;28:13161-72 pubmed publisher
    ..Nogo-66 receptor 1 (NGR or RTN4R) has been considered to be a 22q11 candidate gene for schizophrenia susceptibility because it encodes an axonal ..
  58. Fang Y, Yao L, Li C, Wang J, Wang J, Chen S, et al. The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice. J Neuroinflammation. 2016;13:56 pubmed publisher
    ..The Nogo/NgR signal pathway is involved in AD pathological features, but the detailed mechanism needs further investigation...
  59. Zhang S, Zhou Y, Zhang K, Luan J, Qi S. [Neuroprotective effect of Nogo-66 receptor silencing in preterm rats with brain injury caused by intrauterine infection]. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:1035-1043 pubmed
    To investigate the effect of Nogo-66 receptor (NgR) silencing with specific small interfering RNA (siRNA) on brain injury repair in preterm rats with brain injury caused by intrauterine infection and related mechanism of action...
  60. Liu L, Li H, Zhang M, Lv X. Effects of targeted nano-delivery systems combined with hTERT-siRNA and Bmi-1-siRNA on MCF-7 cells. Int J Clin Exp Pathol. 2015;8:6674-82 pubmed
    ..The polyethyleneimine (PEI)/siRNA nano-condensate was synthesized using PEI and modified using an NGR peptide fragment for targeting to tumor cells...
  61. Sun Z, Dai X, Li Y, Jiang S, Lou G, Cao Q, et al. A novel Nogo-66 receptor antagonist peptide promotes neurite regeneration in vitro. Mol Cell Neurosci. 2016;71:80-91 pubmed publisher
    ..98Da) has a potential ability in crossing blood brain barrier and will be a promising therapeutic agent for the treatment of spinal cord injury and neurodegenerative diseases. ..
  62. Xu J, He J, He H, Peng R, Xi J. Comparison of RNAi NgR and NEP1-40 in Acting on Axonal Regeneration After Spinal Cord Injury in Rat Models. Mol Neurobiol. 2017;54:8321-8331 pubmed publisher
    ..Both NEP1-40 and siNgR had repairing effects on SCI, suggesting their role in facilitating axonal regeneration after SCI. ..
  63. Ferraro G. Refining our understanding of NgR1 function during myelin inhibition. J Neurosci. 2007;27:11451-2 pubmed
  64. Saha N, Kolev M, Nikolov D. Structural features of the Nogo receptor signaling complexes at the neuron/myelin interface. Neurosci Res. 2014;87:1-7 pubmed publisher
    ..In this review, we highlight these studies and summarize our current understanding of the multi-protein cell-surface complexes mediating inhibitory signaling events at the neuron/myelin interface. ..
  65. Takase H, Kurihara Y, Yokoyama T, Kawahara N, Takei K. LOTUS overexpression accelerates neuronal plasticity after focal brain ischemia in mice. PLoS ONE. 2017;12:e0184258 pubmed publisher
    b>Nogo receptor-1 (NgR1) and its ligands inhibit neuronal plasticity and limit functional recovery after brain damage such as ischemic stroke...
  66. Zeng K, Zhong B, Shen X, Fang M, Lin B, Ma D. RNAi targeting Nogo Receptor enhanced survival and proliferation of murine retinal ganglion cells during N-methyl-D-aspartate-induced optic nerve crush. Oncotarget. 2017;8:65009-65021 pubmed publisher
    We investigated the effects of lentivirus-mediated RNAi targeting of Nogo Receptor (NgR) on the proliferation and survival of murine retinal ganglion cells (mRGCs) in vitro and in vivo...
  67. Schmidt L, Stucke Ring J, Brand C, Schliemann C, Harrach S, Muley T, et al. CD13 as target for tissue factor induced tumor vascular infarction in small cell lung cancer. Lung Cancer. 2017;113:121-127 pubmed publisher
    ..It represents a potential candidate for molecular targeted therapy, e.g. employing truncated tissue factor (tTF)-NGR, which can bind CD13 and thereby induce tumor vascular infarction...
  68. Meabon J, de Laat R, Ieguchi K, Wiley J, Hudson M, Bothwell M. LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments. J Biol Chem. 2015;290:9511-20 pubmed publisher
    ..myelin glycoprotein, and myelin basic protein) to a putative tripartite LINGO-1·p75(NTR)·Nogo-66 receptor (NgR) complex at the cell surface...
  69. Bouchet S, Tang R, Fava F, Legrand O, Bauvois B. The CNGRC-GG-D(KLAKLAK)2 peptide induces a caspase-independent, Ca2+-dependent death in human leukemic myeloid cells by targeting surface aminopeptidase N/CD13. Oncotarget. 2016;7:19445-67 pubmed publisher
    The CD13 antigen's binding site for the Asn-Gly-Arg (NGR) motif enables NGR-containing chemotherapeutic drugs to be delivered to CD13-positive tumours...
  70. Denas G, Zoppellaro G, Padayattil Jose S, Antonucci E, Marongiu F, Poli D, et al. Warfarin prescription in patients with nonvalvular atrial fibrillation and one non-gender-related risk factor (CHA2 DS2 VASc 1 or 2): A treatment dilemma. Cardiovasc Ther. 2017;: pubmed publisher
    The issue of anticoagulation in individuals with nonvalvular atrial fibrillation (NVAF) and 1 non-gender-related (NGR) risk factor is subject to debate...
  71. Ng C, Tang B. Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. J Neurosci Res. 2002;67:559-65 pubmed
    ..The 66-amino acid extracellular domain of Nogo (Nogo-66) interacts with a high-affinity receptor (NgR), a glycosylphosphatidylinositol (GPI)-linked protein with multiple leucine-rich repeats...
  72. Perreault L, Temprosa M, Mather K, Horton E, Kitabchi A, Larkin M, et al. Regression from prediabetes to normal glucose regulation is associated with reduction in cardiovascular risk: results from the Diabetes Prevention Program outcomes study. Diabetes Care. 2014;37:2622-31 pubmed publisher
    Restoration of normal glucose regulation (NGR) in people with prediabetes significantly decreases the risk of future diabetes...
  73. Pronker M, Tas R, Vlieg H, Janssen B. Nogo Receptor crystal structures with a native disulfide pattern suggest a novel mode of self-interaction. Acta Crystallogr D Struct Biol. 2017;73:860-876 pubmed publisher
    The Nogo Receptor (NgR) is a glycophosphatidylinositol-anchored cell-surface protein and is a receptor for three myelin-associated inhibitors of regeneration: myelin-associated glycoprotein, Nogo66 and oligodendrocyte myelin glycoprotein...
  74. Hsu R, Woodroffe A, Lai W, Cook M, Mukai J, Dunning J, et al. Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches. PLoS ONE. 2007;2:e1234 pubmed
    b>NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene...
  75. Huebner E, Kim B, Duffy P, Brown R, Strittmatter S. A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1. J Biol Chem. 2011;286:18026-36 pubmed publisher
    ..Thus, NgR1 is the predominant receptor for Nogo-22 in regenerating cortical neurons. ..
  76. Sozmen E, Rosenzweig S, Llorente I, DiTullio D, Machnicki M, Vinters H, et al. Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice. Proc Natl Acad Sci U S A. 2016;113:E8453-E8462 pubmed publisher
    ..The OPC maturation block after white matter stroke is in part mediated via Nogo receptor 1 (NgR1) signaling...
  77. Lo Bianco L, Attrotto M, Torretta S, Masellis R, Rampino A, D Ambrosio E, et al. Genetic variation is associated with RTN4R expression and working memory processing in healthy humans. Brain Res Bull. 2017;134:162-167 pubmed publisher
    The Nogo receptor (NgR) is implicated in neurodevelopmental processes and it participates in inhibiting axonal growth...
  78. Pasaje C, Bae J, Park B, Park C, Kim B, Lee C, et al. Lack of association of the RTN4R genetic variations with risk of schizophrenia and SPEM abnormality in a Korean population. Psychiatry Res. 2011;189:312-4 pubmed publisher
    This study examined the association of the reticulon 4 receptor (RTN4R) gene with schizophrenia and smooth pursuit eye movement (SPEM) abnormality in a Korean population...
  79. Sheng W, Gong J, Jiang M, Zhen Y. The recombinant EGFR/CD13 bi-targeted fusion protein induces apoptosis and blocks tube formation. Oncol Rep. 2017;38:3507-3514 pubmed publisher
    Previously it was shown that the recombinant EGFR/CD13 bi-targeted fusion protein ER(Fv)?LDP-NGR which consists of an anti?EGFR scFv antibody fragment, a tri?cyclic NGR peptide, and a lidamycin-derived apoprotein, inhibited the ..
  80. Sanz R, Ferraro G, Kacervosky J, Salesse C, Gowing E, Hua L, et al. MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding. J Neurosci. 2018;38:518-529 pubmed publisher
    ..We propose that MT3-MMP activity and NgR1 shedding could stimulate circuitry remodeling in the adult brain and enhance functional connectivity after brain injury. ..
  81. Thompson C, Karelis J, Middleton F, Gentile K, Coman I, Radoeva P, et al. Associations between neurodevelopmental genes, neuroanatomy, and ultra high risk symptoms of psychosis in 22q11.2 deletion syndrome. Am J Med Genet B Neuropsychiatr Genet. 2017;174:295-314 pubmed publisher
    ..Participants were genotyped for 10 SNPs in the COMT, DGCR8, GNB1L, PIK4CA, PRODH, RTN4R, and ZDHHC8 genes. All subjects were assessed for ultra high risk symptoms of psychosis...
  82. Shi X, Yu W, Yang T, Liu W, Zhao Y, Sun Y, et al. Panax notoginseng saponins provide neuroprotection by regulating NgR1/RhoA/ROCK2 pathway expression, in vitro and in vivo. J Ethnopharmacol. 2016;190:301-12 pubmed publisher
    ..PNS provided neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1, RhoA, and ROCK2. ..
  83. Park J, Widi G, Gimbel D, Harel N, Lee D, Strittmatter S. Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice. J Neurosci. 2006;26:13279-86 pubmed
    ..Previously, we found that the Nogo-66 receptor (NgR) interacts physically with both Abeta and the amyloid precursor protein (APP)...
  84. Lee E, McClelland M, Wang Y, Long F, Choi S, Lee J. Distinct DNA methylation profiles between adenocarcinoma and squamous cell carcinoma of human uterine cervix. Oncol Res. 2010;18:401-8 pubmed
    ..Hypermethylation of loci in PAK6 and NOGOR most strongly correlated with ACA...
  85. Mary J, Jittmittraphap A, Chattanadee S, Leaungwutiwong P, Shenbagarathai R. A synthetic peptide derived from domain III envelope glycoprotein of Dengue virus induces neutralizing antibody. Virus Genes. 2018;54:25-32 pubmed publisher
    ..A fifteen-amino-acid-long peptide that includes the NGR motif was chemically synthesized and conjugated with keyhole limpet hemocyanin...
  86. Amy M, Staehlin O, René F, Blasco H, Marouillat S, Daoud H, et al. A common functional allele of the Nogo receptor gene, reticulon 4 receptor (RTN4R), is associated with sporadic amyotrophic lateral sclerosis in a French population. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16:490-6 pubmed publisher
    ..Nogo protein inhibits neurite outgrowth and is overexpressed in muscle in ALS. Our aims were to study the reticulon 4 receptor gene RTN4R which encodes Nogo 1 receptor (NgR1) in SALS, to test if the variants were associated with ..
  87. Konopka Anstadt J, Mainou B, Sutherland D, Sekine Y, Strittmatter S, Dermody T. The Nogo receptor NgR1 mediates infection by mammalian reovirus. Cell Host Microbe. 2014;15:681-91 pubmed publisher
    ..However, JAM-A is dispensable for reovirus replication in the CNS. We demonstrate that reovirus binds Nogo receptor NgR1, a leucine-rich repeat protein expressed in the CNS, to infect neurons...
  88. Corti A, Gasparri A, Ghitti M, Sacchi A, Sudati F, Fiocchi M, et al. Glycine N-methylation in NGR-Tagged Nanocarriers Prevents Isoaspartate formation and Integrin Binding without Impairing CD13 Recognition and Tumor Homing. Adv Funct Mater. 2017;27: pubmed publisher
    b>NGR (asparagine-glycine-arginine) is a tumor vasculature-homing peptide motif widely used for the functionalization of drugs, nanomaterials and imaging compounds for cancer treatment and diagnosis...
  89. Cai X, Wang Z, Cao J, Ni J, Xu Y, Yao J, et al. Anti-angiogenic and anti-tumor effects of metronomic use of novel liposomal zoledronic acid depletes tumor-associated macrophages in triple negative breast cancer. Oncotarget. 2017;8:84248-84257 pubmed publisher
    ..Therefore, in this study, Asn-Gly-Arg (NGR) and PEG2000 were used as ligands to modify the surface of liposomes (NGR-PEG-LP-ZOL) in metronomic therapy to ..
  90. Domeniconi M, Zampieri N, Spencer T, Hilaire M, Mellado W, Chao M, et al. MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron. 2005;46:849-55 pubmed
  91. Vats K, Satpati D, Sharma R, Kumar C, Sarma H, Banerjee S. Preparation and Comparative evaluation of 99m Tc-HYNIC-cNGR and 99m Tc-HYNIC-PEG2 -cNGR as Tumor Targeting Molecular Imaging Probes. J Labelled Comp Radiopharm. 2017;: pubmed publisher
    The tripeptide sequence NGR (asparagine-glycine-arginine) specifically recognizes aminopeptidase N (APN or CD13) receptors highly expressed on tumor cells as well as tumor vasculature...
  92. Pokpas K, Jahed N, Baker P, Iwuoha E. Complexation-Based Detection of Nickel(II) at a Graphene-Chelate Probe in the Presence of Cobalt and Zinc by Adsorptive Stripping Voltammetry. Sensors (Basel). 2017;17: pubmed publisher
    ..onto a glassy carbon electrode (GCE) modified with dimethylglyoxime (DMG) as chelating agent and a Nafion-graphene (NGr) nanocomposite to enhance electrode sensitivity...