RREB1

Summary

Gene Symbol: RREB1
Description: ras responsive element binding protein 1
Alias: FINB, HNT, LZ321, RREB-1, Zep-1, DNA-binding protein, finger protein in nuclear bodies, hindsight homolog, raf-responsive zinc finger protein LZ321, zinc finger motif enhancer binding protein 1, zinc finger motif enhancer-binding protein 1, zinc finger motif-enhancer binding-protein 1
Species: human

Top Publications

  1. pmc Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    Circ Cardiovasc Genet 3:523-30. 2010
  2. ncbi p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB
    Shuling Zhang
    Laboratory of Genetics, Center for Cancer Research, Bethesda, MD 20892 4255, USA
    Oncogene 22:2285-95. 2003
  3. ncbi The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer
    Nishit K Mukhopadhyay
    Department of Urology Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Mol Endocrinol 21:2056-70. 2007
  4. doi RREB-1 is a transcriptional repressor of HLA-G
    Sébastien Flajollet
    Commissariat a l Energie Atomique, Direction des Sciences du Vivant, IBM, Service de Recherches en Hemato Immunologie, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    J Immunol 183:6948-59. 2009
  5. pmc RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas
    A Thiagalingam
    Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Mol Cell Biol 16:5335-45. 1996
  6. pmc Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1
    Subir K Ray
    Division of Gastroenterology, GRASP Digestive Disease Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 23:259-71. 2003
  7. pmc Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells
    Beatrice C Milon
    Department of Oncology and Diagnostic Sciences, Dental School, Greenebaum Cancer Center, University of Maryland Baltimore, Baltimore, MD 21201, USA
    Prostate 70:288-96. 2010
  8. pmc RREB1 transcription factor splice variants in urologic cancer
    Matthew D Nitz
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    Am J Pathol 179:477-86. 2011
  9. pmc Developmental silencing of human zeta-globin gene expression is mediated by the transcriptional repressor RREB1
    Ruei Lin Chen
    Department of Life Sciences and Institute of Genome Sciences, National Yang Ming University, Taipei 11221, Taiwan
    J Biol Chem 285:10189-97. 2010
  10. doi DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter
    Hanshao Liu
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Biochem J 422:543-51. 2009

Detail Information

Publications513 found, 100 shown here

  1. pmc Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    Circ Cardiovasc Genet 3:523-30. 2010
    ....
  2. ncbi p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB
    Shuling Zhang
    Laboratory of Genetics, Center for Cancer Research, Bethesda, MD 20892 4255, USA
    Oncogene 22:2285-95. 2003
    ..BALB/c mice have both regulatory and coding region defects that may contribute to the impairment of p16 gene function...
  3. ncbi The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer
    Nishit K Mukhopadhyay
    Department of Urology Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Mol Endocrinol 21:2056-70. 2007
    ..Collectively, our data for the first time identify RREB-1 as a repressor of AR and further implicate the Ras/MAPK kinase pathway as a likely antagonist of the inhibitory effects of RREB-1 on androgenic signaling...
  4. doi RREB-1 is a transcriptional repressor of HLA-G
    Sébastien Flajollet
    Commissariat a l Energie Atomique, Direction des Sciences du Vivant, IBM, Service de Recherches en Hemato Immunologie, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    J Immunol 183:6948-59. 2009
    ..This demonstration is the first of a repressor factor of HLA-G transcriptional activity taking part in HLA-G repression by epigenetic mechanisms...
  5. pmc RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas
    A Thiagalingam
    Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Mol Cell Biol 16:5335-45. 1996
    ..These data suggest that RREB-1 may play a role in Ras and Raf signal transduction in medullary thyroid cancer and other cells...
  6. pmc Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1
    Subir K Ray
    Division of Gastroenterology, GRASP Digestive Disease Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 23:259-71. 2003
    ..We identified by expression cloning the zinc finger protein RREB-1, also known to exist as a longer form, Finb, as the protein binding to one of the mutationally sensitive elements...
  7. pmc Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells
    Beatrice C Milon
    Department of Oncology and Diagnostic Sciences, Dental School, Greenebaum Cancer Center, University of Maryland Baltimore, Baltimore, MD 21201, USA
    Prostate 70:288-96. 2010
    ..However, the mechanism of hZIP1 down-regulation is not known. We have hypothesized that hZIP1 is down-regulated through transcriptional regulation...
  8. pmc RREB1 transcription factor splice variants in urologic cancer
    Matthew D Nitz
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    Am J Pathol 179:477-86. 2011
    b>RREB1 is an alternatively spliced transcription factor implicated in Ras signaling and cancer. Little is known about the expression of RREB1 isoforms in cell lines or human tumors, or about the clinical relevance of the latter...
  9. pmc Developmental silencing of human zeta-globin gene expression is mediated by the transcriptional repressor RREB1
    Ruei Lin Chen
    Department of Life Sciences and Institute of Genome Sciences, National Yang Ming University, Taipei 11221, Taiwan
    J Biol Chem 285:10189-97. 2010
    ..suggest that repression of the human zeta-globin promoter is mediated through binding of the zinc finger factor RREB1 to ZF2...
  10. doi DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter
    Hanshao Liu
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Biochem J 422:543-51. 2009
    ..We also show that, upon exposure to genotoxic stress, RREB-1 controls apoptosis in a p53-dependent manner. These findings provide evidence that RREB-1 participates in modulating p53 transcription in response to DNA damage...
  11. pmc Derepression of DNA damage-regulated genes requires yeast TAF(II)s
    B Li
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802 4500, USA
    EMBO J 19:4091-100. 2000
    ..Our results indicate that yeast TAF(II)s have other functions in addition to core promoter selectivity, and describe a novel activity: the derepression of promoters...
  12. pmc The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
    G S Brush
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 93:15075-80. 1996
    ....
  13. ncbi The Mfd protein of Bacillus subtilis 168 is involved in both transcription-coupled DNA repair and DNA recombination
    S Ayora
    , , E-28049, Madrid, Spain
    J Mol Biol 256:301-18. 1996
    ..The Mfd protein is a sequence-independent DNA binding protein with weak ATPase activity. The Mfd protein was able to displace in vitro B. subtilis or E...
  14. ncbi Saccharomyces cerevisiae proteins involved in hybrid DNA formation in vitro
    W D Heyer
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
    Biochimie 73:269-76. 1991
    ..We have identified two proteins that functionally interact with SEP1. First, an Mr 34,000 single-stranded DNA binding protein stimulated the reaction by lowering the requirement for SEP1 about 3-4 fold...
  15. ncbi Role of the conserved carboxy-terminal alpha-helix of Rad6p in ubiquitination and DNA repair
    Y Dor
    Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Israel
    Mol Microbiol 21:1197-206. 1996
    ..Mutants affecting several functions of the 26S proteasome retain wild-type capacity for error-free DNA repair. This raises the possibility that ubiquitination by Rad6p in DNA repair does not target proteins for proteasomal degradation...
  16. ncbi Evidence for nucleosomal phasing and a novel protein specifically binding to cucumber satellite DNA
    T C Fischer
    , Biologisches Institut, , Bundesrepublik Deutschland
    Z Naturforsch C 49:79-86. 1994
    ..For the first time in plants, a satellite DNA-binding protein with an apparent molecular weight of 14 kDa (SAT 14) was identified...
  17. pmc Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinase
    L J Blackwell
    Department of Biochemistry, New York University Medical Center, New York 10016, USA
    Mol Cell Biol 16:4798-807. 1996
    ..Our results indicate that hRPA binds ssDNA in a multistep pathway, inducing new hRPA alignments and conformations that can modulate the functional interaction of other factors with hRPA...
  18. ncbi Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution
    D K Worthylake
    Biochemistry Department, University of Utah, Salt Lake City, Utah 84132, USA
    J Biol Chem 273:6271-6. 1998
    ..via interaction with the ubiquitin-protein ligase Ubr1 and in DNA repair via interactions with the DNA binding protein Rad18. We report here the crystal structure of Rad6 refined at 2.6 A resolution to an R factor of 21.3%...
  19. ncbi Coordinated leading- and lagging-strand synthesis at the Escherichia coli DNA replication fork. III. A polymerase-primase interaction governs primer size
    E L Zechner
    Graduate Program in Molecular Biology, Cornell University Graduate School of Medical Sciences, New York, New York 10021
    J Biol Chem 267:4054-63. 1992
    ..form II DNA template, the DNA polymerase III holoenzyme (Pol III HE), the Escherichia coli single-stranded DNA binding protein, and the primosome, showed that within the context of a replication fork, the oligoribonucleotide primers ..
  20. pmc Colocalization of baculovirus IE-1 and two DNA-binding proteins, DBP and LEF-3, to viral replication factories
    K Okano
    Laboratory of Molecular Entomology and Baculovirology, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama, Japan
    J Virol 73:110-9. 1999
    ..These results suggested that there are about 15 preexisting sites per nucleus which are associated with the initiation of viral DNA replication and assembly of viral DNA replication factories...
  21. ncbi Analysis of a novel DNA-binding protein kinase CKII-like enzyme of Chironomus cells
    J Stigare
    Karolinska Institutet, Department of Cell and Molecular Biology, Laboratory of Medical Cell Biology, Stockholm, Sweden
    Cell Mol Biol Res 40:463-72. 1994
    ..The biochemical and immunological data taken together strongly suggest that CK42 is a novel DNA-binding protein kinase that is not the alpha subunit of CKII...
  22. pmc The single-stranded DNA-binding protein of Deinococcus radiodurans
    Julie Malia Eggington
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    BMC Microbiol 4:2. 2004
    ..Immediately upstream of the ssb gene is another gene (DR0099) given an ssb-like annotation, but left unexplored...
  23. ncbi The putative DNA-binding protein Sto12a from the thermoacidophilic archaeon Sulfolobus tokodaii contains intrachain and interchain disulfide bonds
    Akeo Shinkai
    RIKEN SPring 8 Center, Harima Institute, 1 1 1 Kouto, Sayo, Hyogo 679 5148, Japan
    J Mol Biol 372:1293-304. 2007
    ..This is a novel fold among winged-helix DNA-binding proteins. Possible DNA-binding interactions of the Sto12a protein are discussed based on the crystal structure of Sto12a and comparisons to other winged-helix DNA-binding proteins...
  24. ncbi [Recent progress in mycobacteriology]
    Masaji Okada
    Clinical Research Center, National Hospital Organization Kinki chuo Chest Medical Center, Japan
    Kekkaku 82:783-99. 2007
    ..These data indicate that our novel DNA vaccine might be useful against TB for human clinical trials...
  25. ncbi Structural and functional studies of the rat mitochondrial single strand DNA binding protein P16
    G D Hoke
    Department of Biochemistry and Molecular Biophysics, Virginia Commonwealth University, Richmond 23298
    Arch Biochem Biophys 282:116-24. 1990
    The rat mitochondrial single strand DNA binding protein (SSB) P16 was purified to apparent homogeneity by elution from single strand DNA agarose with ethidium bromide...
  26. ncbi Contribution of a salt bridge to the thermostability of DNA binding protein HU from Bacillus stearothermophilus determined by site-directed mutagenesis
    S Kawamura
    Laboratory of Biochemistry, Faculty of Agriculture, Kyushu University, Higashi ku, Fukuoka
    J Biochem 121:448-55. 1997
    ..Glu34, Arg37, and Lys38, to the thermostability of the thermophilic protein, Bacillus stearothermophilus DNA binding protein HU (BstHU), relative to the mesophilic homologue, Bacillus subtilis HU (BsuHU)...
  27. pmc Characterization of a baculovirus lacking the DBP (DNA-binding protein) gene
    Adam L Vanarsdall
    Department of Microbiology, Nash Hall Room 220, Oregon State University, Corvallis, OR 97331 3804, USA
    Virology 364:475-85. 2007
    ..Finally, immunoelectron microscopic analysis of cells transfected with the dbp knockout revealed that DBP is required for the production of normal-appearing nucleocapsids and for the generation of the virogenic stroma...
  28. pmc Structural studies of bacteriophage alpha3 assembly
    Ricardo A Bernal
    Department of Biological Sciences, Purdue University, 1392 Lilly Hall, West Lafayette, IN 47907 1392, USA
    J Mol Biol 325:11-24. 2003
    ..The icosahedrally ordered structural component of the ssDNA appears to be substantially increased in alpha3 compared to phiX174, allowing the building of about 10% of the ribose-phosphate backbone...
  29. pmc Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies
    Kunihiro Uryu
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 67:555-64. 2008
    ..These findings provide further insight into the burden and clinical significance of TDP-43 pathology in disorders other than FTLD-U and amyotrophic lateral sclerosis...
  30. ncbi Differential interaction of the dual alpha tropomyosin/N5 enhancer with multiple DNA binding proteins: N5 is a putative novel z-ZIP DNA binding protein
    N Ruiz-Opazo
    Section of Molecular Genetics, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118
    Cell Mol Biol Res 40:265-72. 1994
    ..with a particular enhancer modular sequence (delimited to 18 bp- to 38 bp-long); and that likewise, a DNA binding protein can bind specifically to different DNA enhancer modular sequences with apparent different affinities...
  31. ncbi Two types of localization of the DNA-binding proteins within the Escherichia coli nucleoid
    T A Azam
    Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Genes Cells 5:613-26. 2000
    ..The intracellular localization of these proteins in E. coli could be predicted from these data, but no attempt has been made thus far to directly observe the intracellular distribution of the DNA-binding proteins...
  32. pmc Strand displacement by DNA polymerase III occurs through a tau-psi-chi link to single-stranded DNA-binding protein coating the lagging strand template
    Quan Yuan
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA
    J Biol Chem 284:31672-9. 2009
    ..is distinguished from the single-stranded DNA-templated reaction by a high dependence upon single-stranded DNA binding protein and an inability of gamma-complex to support the reaction in the absence of tau...
  33. pmc CC1, a novel crenarchaeal DNA binding protein
    Xiao Luo
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, UK
    J Bacteriol 189:403-9. 2007
    ..crenarchaea Pyrobaculum aerophilum and Thermoproteus tenax lack any obvious gene encoding a single-stranded DNA binding protein (SSB)...
  34. ncbi Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders
    J N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 32:1157-65. 2001
    ..These data also indicate that multilayered epithelium is phenotypically similar to, and may share a lineage relationship with, mucosal gland duct epithelium...
  35. pmc Role of the adenovirus DNA-binding protein in in vitro adeno-associated virus DNA replication
    P Ward
    Department of Microbiology, Hearst Microbiology Research Center, Cornell University Medical College, New York, New York 10021, USA
    J Virol 72:420-7. 1998
    ..Extracts supplemented with Ad-DBP preferentially replicated AAV sequences rather than adjacent vector sequences; in contrast, extracts supplemented with RPA preferentially replicated vector sequences...
  36. ncbi Isolation and characterization of the gene encoding single-stranded-DNA-binding protein (SSB) from four marine Shewanella strains that differ in their temperature and pressure optima for growth
    L N Chilukuri
    Center for Marine Biotechnology and Biomedicine, Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla 92093 0202, USA
    Microbiology 143:1163-74. 1997
    ..The differences found among the Shewanella SSBs suggest that these proteins will provide a useful system for exploring the adaptation of protein-protein and protein-DNA interactions at low temperature and high pressure...
  37. doi Induction of paranodal myelin detachment and sodium channel loss in vivo by Campylobacter jejuni DNA-binding protein from starved cells (C-Dps) in myelinated nerve fibers
    Hua Piao
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurol Sci 288:54-62. 2010
    ..Thus, we consider that C-Dps damages myelinated nerve fibers, possibly through interference with paranodal sulfatide function, and may contribute to the axonal pathology seen in C. jejuni-related GBS...
  38. pmc Escherichia coli single-stranded DNA-binding protein mediates template recycling during transcription by bacteriophage N4 virion RNA polymerase
    Elena K Davydova
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 100:9250-5. 2003
    ..No sequence similarity to this domain exists in vRNAP. Hereby, we propose a unique role for EcoSSB: It functionally substitutes in N4 vRNAP for the N-terminal domain of T7 RNAP responsible for RNA binding...
  39. pmc Bombyx mori nucleopolyhedrovirus encodes a DNA-binding protein capable of destabilizing duplex DNA
    V S Mikhailov
    N K Koltzov Institute of Developmental Biology, Moscow, Russia
    J Virol 72:3107-16. 1998
    ..This helix-destabilizing ability is consistent with the prediction that DBP functions as a single-stranded DNA binding protein in virus replication.
  40. ncbi Structural analysis of the chromosome segregation protein Spo0J from Thermus thermophilus
    Thomas A Leonard
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Mol Microbiol 53:419-32. 2004
    ..We hypothesize that the C-terminus mediates dimerization of Spo0J, thereby effectively increasing the local concentration of the N-termini, which most probably dimerize, as shown by our structure, upon binding to a cognate parS site...
  41. pmc Functional roles of the N- and C-terminal regions of the human mitochondrial single-stranded DNA-binding protein
    Marcos T Oliveira
    Department of Biochemistry and Molecular Biology, Center for Mitochondrial Science and Medicine, and Graduate Program in Genetics, Michigan State University, East Lansing, Michigan, United States of America
    PLoS ONE 5:e15379. 2010
    ..We discuss our findings in the context of species-specific components of the mtDNA replisome, and in comparison with various prokaryotic DNA replication machineries...
  42. pmc Isolation and characterization of the DNA-binding protein (DBP) of the Autographa californica multiple nucleopolyhedrovirus
    Victor S Mikhailov
    Department of Microbiology, Oregon State University, Corvallis, OR 97331 3804, USA
    Virology 370:415-29. 2008
    ..These activities and a tight association with subnuclear structures suggests that DBP is a component of the virogenic stroma that is involved in the processing of replicative intermediates...
  43. ncbi Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene
    J A Menendez
    Department of Medicine, Breast Cancer Translational Research Program, Evanston Northwestern Healthcare Research Institute, Evanston, IL, USA
    Ann Oncol 16:1253-67. 2005
    ..FAS (oncogenic antigen-519) is up-regulated in about 50% of breast cancers, is an indicator of poor prognosis, and has recently been functionally associated with the Her2/neu (erbB-2) oncogene...
  44. pmc Identification and characterization of a phase-specific, nuclear DNA binding protein from the dimorphic pathogenic fungus Histoplasma capsulatum
    F E Abidi
    Center for Molecular Studies, J C Self Research Institute, Greenwood Genetics Center, Greenwood, South Carolina 29646, USA
    Infect Immun 66:3867-73. 1998
    ..capsulatum which binds to target sequences in a phase-specific manner, suggesting that p30M may govern aspects of gene transcription in this pathogenic fungus, in which a temperature-sensitive switch influences morphology and virulence...
  45. ncbi Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43
    Yvonne Davidson
    Clinical Neuroscience Research Group, Division of Medicine and Neuroscience, Greater Manchester Neurosciences Centre, Hope Hospital, University of Manchester, Salford, M6 8HD, UK
    Acta Neuropathol 113:521-33. 2007
    ..We conclude that the UBQ-ir lesions of FTLD and MND are defined by the presence of TDP-43, and that these disorders can be subsumed into a single disease entity under the umbrella of TDP-43 proteinopathy...
  46. pmc Biochemical interaction of the Escherichia coli RecF, RecO, and RecR proteins with RecA protein and single-stranded DNA binding protein
    K Umezu
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 90:3875-9. 1993
    ..As shown by other workers, joint molecule formation by RecA was inhibited by E. coli single-stranded DNA binding protein (SSB) when it was added to single-stranded DNA before RecA...
  47. pmc A novel class of plant-specific zinc-dependent DNA-binding protein that binds to A/T-rich DNA sequences
    Y Nagano
    Graduate School of Agricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Nucleic Acids Res 29:4097-105. 2001
    ..These results indicate that PLATZ1 is a novel class of plant-specific zinc-dependent DNA-binding protein responsible for A/T-rich sequence-mediated transcriptional repression...
  48. pmc The AcMNPV pp31 gene is not essential for productive AcMNPV replication or late gene transcription but appears to increase levels of most viral transcripts
    Junya Yamagishi
    Boyce Thompson Institute at Cornell University, Ithaca, NY 14853, USA
    Virology 365:34-47. 2007
    The pp31 gene of Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) encodes a phosphorylated DNA binding protein that associates with virogenic stroma in the nuclei of infected cells...
  49. ncbi A postsynaptic role for single-stranded DNA-binding protein in recA protein-promoted DNA strand exchange
    P E Lavery
    Department of Cell, Molecular, and Structural Biology, Northwestern University Medical School, Chicago, Illinois 60611
    J Biol Chem 267:9315-20. 1992
    ....
  50. pmc Growth phase-dependent variation in protein composition of the Escherichia coli nucleoid
    T Ali Azam
    Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    J Bacteriol 181:6361-70. 1999
    ..These changes in the composition of nucleoid-associated proteins in the stationary phase are accompanied by compaction of the genome DNA and silencing of the genome functions...
  51. pmc A DNA-binding peroxiredoxin of Coxiella burnetii is involved in countering oxidative stress during exponential-phase growth
    Linda D Hicks
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA
    J Bacteriol 192:2077-84. 2010
    ..Taken as a whole, the results show that Coxiella BCP binds DNA and likely serves to detoxify endogenous hydroperoxide byproducts of Coxiella's metabolism during intracellular replication...
  52. pmc Binding of the dimeric Deinococcus radiodurans single-stranded DNA binding protein to single-stranded DNA
    Alexander G Kozlov
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Biochemistry 49:8266-75. 2010
    Deinococcus radiodurans single-stranded (ss) DNA binding protein (DrSSB) originates from a radiation-resistant bacterium and participates in DNA recombination, replication, and repair...
  53. ncbi Temperature-sensitive mutants of adenovirus single-stranded DNA-binding protein. Inability to support DNA replication is associated with an altered DNA-binding activity of the protein
    M Tsuji
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38101
    J Biol Chem 266:16178-87. 1991
    ..Thus, the inability of these three ts DBPs to support DNA replication is attributable to their altered DNA-binding properties...
  54. ncbi Mitochondrial single-stranded DNA-binding protein from Drosophila embryos. Physical and biochemical characterization
    P Thommes
    Marie Curie Research Institute, Oxted, Surrey, United Kingdom
    J Biol Chem 270:21137-43. 1995
    ..The homogeneous protein stimulates the activity of mitochondrial DNA polymerase from D. melanogaster embryos, increasing dramatically the rate of initiation of DNA synthesis on a singly primed DNA template...
  55. doi Orchestration of Haemophilus influenzae RecJ exonuclease by interaction with single-stranded DNA-binding protein
    Ruchika Sharma
    Department of Biochemistry, Indian Institute of Science, Bangalore, India
    J Mol Biol 385:1375-96. 2009
    ..In addition, these results implicate SSB as being involved in the recruitment of RecJ to DNA and provide insights into the interplay between these proteins in repair and recombination pathways...
  56. pmc C-terminal phenylalanine of bacteriophage T7 single-stranded DNA-binding protein is essential for strand displacement synthesis by T7 DNA polymerase at a nick in DNA
    Sharmistha Ghosh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 284:30339-49. 2009
    ..gp2.5 lacking the C-terminal phenylalanine does not support this event with wild-type DNA polymerase but does to a limited extent with T7 DNA polymerase harboring the suppressor mutations...
  57. ncbi The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity
    P Beatus
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Mech Dev 104:3-20. 2001
    ..The interplay between the RE/AC region and the ankyrin repeat region provides a basis to understand the difference in HES activation between structurally similar Notch receptors...
  58. ncbi Cloning, sequencing and expression of the two genes encoding the mitochondrial single-stranded DNA-binding protein in Xenopus laevis
    A M Champagne
    Centre de Genetique Moleculaire, CNRS, Gif sur Yvette, France
    Gene 184:65-71. 1997
    In Xenopus laevis the single-stranded DNA binding protein imported into the mitochondria consists of two highly related polypeptides...
  59. ncbi Mechanism of stimulation of DNA replication by bacteriophage phi 29 single-stranded DNA-binding protein p5
    C Gutierrez
    Centro de Biologia Molecular CSIC UAM, Canto Blanco, Madrid, Spain
    J Biol Chem 266:2104-11. 1991
    ..Our results strongly suggest that phi 29 protein p5 is the phi 29 SSB protein active during phi 29 DNA replication...
  60. pmc The C6 zinc finger and adjacent amino acids determine DNA-binding specificity and affinity in the yeast activator proteins LAC9 and PPR1
    M M Witte
    Department of Biochemistry, University of Kentucky, Lexington 40536 0084
    Mol Cell Biol 10:5128-37. 1990
    ....
  61. pmc Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha
    S J Froelich-Ammon
    Department of Chemistry and Biochemistry and Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309 0215, USA
    Genes Dev 12:1504-14. 1998
    ..We conclude that the telomere protein inhibits telomerase by rendering the telomeric DNA inaccessible, thereby helping to maintain telomere length...
  62. ncbi carP, involved in pyrimidine regulation of the Escherichia coli carbamoylphosphate synthetase operon encodes a sequence-specific DNA-binding protein identical to XerB and PepA, also required for resolution of ColEI multimers
    D Charlier
    Research Institute of the CERIA COOVI, Brussels, Belgium
    J Mol Biol 250:392-406. 1995
    ..We propose that integration host factor and CarP/PepA-induced structural modifications in the carAB control region cause conformational changes required to assemble a pyrimidine-specific nucleo-protein regulatory complex...
  63. pmc Binding specificity of Escherichia coli single-stranded DNA binding protein for the chi subunit of DNA pol III holoenzyme and PriA helicase
    Alexander G Kozlov
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Biochemistry 49:3555-66. 2010
    The Escherichia coli single-stranded DNA binding protein (SSB) plays a central role in DNA metabolism through its high affinity interactions with ssDNA, as well as its interactions with numerous other proteins via its unstructured C-..
  64. ncbi Regulation of mitochondrial single-stranded DNA-binding protein gene expression links nuclear and mitochondrial DNA replication in drosophila
    I Ruiz de Mena
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824 1319, USA
    J Biol Chem 275:13628-36. 2000
    ..Our data suggest strongly that the Drosophila mtSSB gene is regulated by the DRE/DREF system. This finding represents a first link between nuclear and mitochondrial DNA replication...
  65. ncbi Crystal structure of the chi:psi sub-assembly of the Escherichia coli DNA polymerase clamp-loader complex
    Jacqueline M Gulbis
    Laboratory of Molecular Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA
    Eur J Biochem 271:439-49. 2004
    ..The base of the clamp-loader complex has an open C-shaped structure, and the shape of the chi:psi complex is suggestive of a loose docking within the crevice formed by the open faces of the delta and delta' subunits of the clamp-loader...
  66. ncbi Helix-destabilizing properties of the baculovirus single-stranded DNA-binding protein (LEF-3)
    V S Mikhailov
    Kol tsov Institute of Developmental Biology, Moscow, 117808, Russia
    Virology 270:180-9. 2000
    ..15 M NaCl. Therefore, the polar destabilization effect of LEF-3 seems to be physiologically important and may be connected, in particular, with the polar action of viral helicase holoenzyme during baculovirus replication...
  67. pmc Anaplasma phagocytophilum p44 mRNA expression is differentially regulated in mammalian and tick host cells: involvement of the DNA binding protein ApxR
    Xueqi Wang
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    J Bacteriol 189:8651-9. 2007
    ..Interestingly, transcription of the A. phagocytophilum gene encoding the DNA binding protein ApxR was also significantly greater in A...
  68. pmc Zuotin, a putative Z-DNA binding protein in Saccharomyces cerevisiae
    S Zhang
    Department of Biology 16 739, Massachusetts Institute of Technology, Cambridge 02139
    EMBO J 11:3787-96. 1992
    A putative Z-DNA binding protein, named zuotin, was purified from a yeast nuclear extract by means of a Z-DNA binding assay using [32P]poly(dG-m5dC) and [32P]oligo(dG-Br5dC)22 in the presence of B-DNA competitor...
  69. pmc Direct stimulus perception and transcription activation by a membrane-bound DNA binding protein
    Susanne Gebhard
    Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, New Zealand
    Mol Microbiol 73:482-91. 2009
    ..The bacitracin resistance regulator, BcrR, of Enterococcus faecalis is a membrane-bound DNA binding protein and is required for bacitracin-dependent expression of the bacitracin resistance genes, bcrABD...
  70. pmc A role for the human single-stranded DNA binding protein HSSB/RPA in an early stage of nucleotide excision repair
    D Coverley
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK
    Nucleic Acids Res 20:3873-80. 1992
    The human single-stranded DNA binding protein (HSSB/RPA) is involved in several processes that maintain the integrity of the genome including DNA replication, homologous recombination, and nucleotide excision repair of damaged DNA...
  71. pmc TDP-43 in aging and Alzheimer's disease - a review
    Andrea C Wilson
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Int J Clin Exp Pathol 4:147-55. 2011
    Transactive response DNA-binding protein of 43 kDa (TDP-43), an RNA and DNA binding protein involved in transcriptional repression, RNA splicing and RNA metabolism during the stress response, is the major component of neuronal inclusions ..
  72. pmc Gel shift analysis of the empA promoter region in Vibrio anguillarum
    Steven M Denkin
    Department of Cell and Molecular Biology, University of Rhode Island, Kingston, RI 02881, USA
    BMC Microbiol 4:42. 2004
    ..anguillarum, M93Sm and NB10. It is hypothesized that differences in empA regulation are due to differences in binding of regulatory elements...
  73. ncbi Superhelical path of the DNA in the nucleoprotein complex that activates the initiation of phage phi 29 DNA replication
    M Serrano
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Canto Blanco, Madrid, Spain
    J Mol Biol 230:248-59. 1993
    ..5 bp/turn) and strongly bent (66 degrees/12 bp). These DNA conformational changes might contribute to the activation of phi 29 DNA initiation of replication by protein p6...
  74. ncbi Cycloheximide induces a subset of low temperature-inducible genes in maize
    T Berberich
    Biotechnology Institute, Akita Prefectural College of Agriculture, Ohgata, Japan
    Mol Gen Genet 254:275-83. 1997
    ..The signal transduction pathways triggered by low temperature and cycloheximide are discussed in relation to these observations...
  75. ncbi De novo quantitative bisulfite sequencing using the pyrosequencing technology
    Jean Michel Dupont
    Laboratoire d Histologie Embryologie Cytogénétique, CHU Cochin Port Royal, AP HP Université Paris 5, 75014 Paris, France
    Anal Biochem 333:119-27. 2004
    ..This allowed accurate and quantitative de novo sequencing of the methylation state of each CpG, showing reproducible variations of methylation state in contiguous CpGs, and proved to be a useful adjunct to current technologies...
  76. ncbi Escherichia coli PriA helicase: fork binding orients the helicase to unwind the lagging strand side of arrested replication forks
    J M Jones
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20007, USA
    J Mol Biol 312:935-47. 2001
    ..In the cell, single-strand-binding protein and fork structure may direct PriA helicase to translocate along the lagging-strand template of forked structures such that the primosome is specifically assembled on that DNA strand...
  77. ncbi The DpsA-homologue of the archaeon Halobacterium salinarum is a ferritin
    Sabine Reindel
    Isotopenlabor TNF, Medizinische Universitat zu Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Biochim Biophys Acta 1598:140-6. 2002
    ..This protein exhibits features of a non-heme type bacterial ferritin (Ftn) although it shares only little sequence homology with Ftn. Molecular modelling disclosed a high structural similarity to E. coli Dps...
  78. doi A polyplex qPCR-based binding assay for protein-DNA interactions
    Morgane J J Moreau
    School of Pharmacy and Molecular Sciences, James Cook University, Townsville, QLD, Australia
    Analyst 137:4111-3. 2012
    ..This new qPCR DNA-binding assay can easily be adapted to determine the binding specificity of virtually any soluble and functional epitope-tagged DNA-binding protein...
  79. pmc Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia
    L Sun
    Parker Hughes Cancer Center, Children s Cancer Group ALL Biology Reference Laboratory, Departments of Genetics, Hughes Institute, St Paul, MN 55113, USA
    Proc Natl Acad Sci U S A 96:680-5. 1999
    ..These results implicate the expression of dominant-negative Ikaros isoforms and the disruption of normal Ikaros function in the leukemogenesis of ALL in infants...
  80. ncbi HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes
    C Imbriano
    Dipartimento di Biologia Animale, U di Modena e Reggio, Via Campi 213 D, 41100 Modena, Italy
    J Biol Chem 276:26332-9. 2001
    ..In yeast two-hybrid assays HSP-CBF interacts with NF-YB. These data implicate HSP-CBF as a non-DNA binding coactivator of heat shock genes that act on a DNA-bound NF-Y...
  81. pmc Association of modified cytosines and the methylated DNA-binding protein MeCP2 with distinctive structural domains of lampbrush chromatin
    Garry T Morgan
    Centre for Genetics and Genomics, School of Biology, University of Nottingham, Queens Medical Centre, Nottingham, NG7 2UH, UK
    Chromosome Res 20:925-42. 2012
    ..This raises the possibility that 5hmC may play a role in establishing the distinctive patterns of gene repression and activation that characterize specific pol III-transcribed gene families in amphibian genomes...
  82. pmc Nap1 regulates proper CENP-B binding to nucleosomes
    Hiroaki Tachiwana
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Nucleic Acids Res 41:2869-80. 2013
    ..We therefore propose a novel mechanism of CENP-B regulation by Nap1...
  83. ncbi Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia
    Aya Hirayama
    Department of Pediatrics, Akita University, Akita, Japan
    Brain Res Dev Brain Res 140:85-92. 2003
    ..These results may reflect myelin repair on dysmyelination around PVL areas. Therefore, MyT1 may play an important role in the myelin repair in PVL regions...
  84. ncbi In vitro transcription termination activity of the Drosophila mitochondrial DNA-binding protein DmTTF
    Marina Roberti
    Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Bari, via Orabona, 4, 70125 Bari, Italy
    Biochem Biophys Res Commun 331:357-62. 2005
    ....
  85. ncbi Sub-speciating Campylobacter jejuni by proteomic analysis of its protein biomarkers and their post-translational modifications
    Clifton K Fagerquist
    Western Regional Research Center, Agricultural Research Service, United States Department of Agriculture, 800 Buchanan Street, Albany, California 94710, USA
    J Proteome Res 5:2527-38. 2006
    ....
  86. pmc TetR is a positive regulator of the tetanus toxin gene in Clostridium tetani and is homologous to botR
    J C Marvaud
    Unité des Toxines Microbiennes, Institut Pasteur, 75724 Paris Cedex 15, France
    Infect Immun 66:5698-702. 1998
    ..TetR has the feature of a DNA binding protein with a basic pI (9.53)...
  87. ncbi The retinitis pigmentosa-mutated RP2 protein exhibits exonuclease activity and translocates to the nucleus in response to DNA damage
    Jung Hoon Yoon
    Division of Biology, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Exp Cell Res 312:1323-34. 2006
    ..The data suggest that RP2 may have previously unrecognized roles as a DNA damage response factor and 3' to 5' exonuclease...
  88. ncbi Activin A induced expression of a fork head related gene in posterior chordamesoderm (notochord) of Xenopus laevis embryos
    S Knochel
    Abteilung Biochemie, Universitat Ulm, Germany
    Mech Dev 38:157-65. 1992
    ..Here we report on XFD-1, a DNA binding protein which can bind to the HNF-3 alpha target sequence...
  89. pmc Isolation of an oxygen-sensitive FNR protein of Escherichia coli: interaction at activator and repressor sites of FNR-controlled genes
    S B Melville
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095, USA
    Proc Natl Acad Sci U S A 93:1226-31. 1996
    The Escherichia coli fnr gene product, FNR, is a DNA binding protein that regulates a large family of genes involved in cellular respiration and carbon metabolism during conditions of anaerobic cell growth...
  90. pmc A class of single-stranded telomeric DNA-binding proteins required for Rap1p localization in yeast nuclei
    L M Konkel
    Department of Plant Biology, University of Minnesota, St Paul 55108, USA
    Proc Natl Acad Sci U S A 92:5558-62. 1995
    ..Furthermore, it demonstrates that, despite their unusual codon bias, C. reinhardtii genes can be efficiently translated in Saccharomyces cerevisiae cells...
  91. pmc Two distinct, sequence-specific DNA-binding proteins interact independently with the major replication pause region of sea urchin mtDNA
    S A Qureshi
    Robertson Institute of Biotechnology, Department of Genetics, University of Glasgow, UK
    Nucleic Acids Res 21:2801-8. 1993
    ..In vitro, mtPBP1 and mtPBP2 bind independently to their high-affinity sites, which are separated by about 50 bp...
  92. pmc Alternative DNA-protein interactions in variable-length internucleosomal regions associated with Drosophila Adh distal promoter expression
    A Ewel
    Department of Biology, University of Rochester, NY 14627
    Nucleic Acids Res 18:1771-81. 1990
    ..Two DNA binding proteins, one being a TATA box binding factor, compete for overlapping sites to allow either assembly of a transcription initiation complex and transcription, or positioning of nucleosomes for stable repression...
  93. doi CHD1 assumes a central role during follicle development
    Argyris Papantonis
    Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece
    J Mol Biol 383:957-69. 2008
    ..In this work, we show that the silkmoth chromo-helicase/ATPase-DNA binding protein 1 (CHD1) ortholog is responsible for repositioning of nucleosomes on chorion promoters, where the factor ..
  94. ncbi Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation
    X Chen
    Department of Biological Sciences, Columbia University, New York, New York 10027
    Genes Dev 7:1837-49. 1993
    ..Although p53 strongly inhibited the interaction of TBP with such DNA, it had virtually no effect on TFIID binding. Thus, transcriptional repression by p53 may require additional functions other than inhibiting TBP binding...
  95. ncbi Heteroduplex formation by human Rad51 protein: effects of DNA end-structure, hRP-A and hRad52
    P Baumann
    Clare Hall Laboratories, Imperial Cancer Research Fund, South Mimms, Hertfordshire, EN6 3LD, UK
    J Mol Biol 291:363-74. 1999
    ..Joint molecule formation by hRad51 was stimulated or inhibited by hRad52, dependent upon the reaction conditions. The inhibitory effect could be overcome by the presence of hRP-A or excess heterologous DNA...
  96. doi Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
    Laura Ferraiuolo
    Academic Neurology Unit, Sheffield Institute for Translational Neuroscience, Department of Neuroscience, School of Medicine and Biomedical Sciences, University of Sheffield, 385a Glossop Road, Sheffield S10 2HQ, UK
    Nat Rev Neurol 7:616-30. 2011
    ..Ongoing research on the cellular pathways highlighted in this Review is predicted to open the door to new therapeutic interventions to slow disease progression in ALS...
  97. doi PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B
    Atsushi Baba
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 13:668-75. 2011
    ....
  98. pmc CHD1L protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival
    Wei Peng He
    Department of Gynecology, The First Affiliated Hospital, Sun Yat Sen University, NO, 78, Zhongshan Road II, 510080 Guangzhou, China
    BMC Cancer 12:437. 2012
    Our recent studies suggested that the chromodomain helicase DNA binding protein 1-like (CHD1L) gene plays an oncogenic role in human hepatocellular carcinoma...
  99. pmc Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis
    M D Scofield
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Neuroscience 227:44-54. 2012
    ..These findings suggest that NAC1 may function to link TDP-43 to the proteasome; thereby, facilitating the post-translational modifications of TDP-43 that lead to the development of ALS...
  100. doi Tuning the Wettability of Halloysite Clay Nanotubes by Surface Carbonization for Optimal Emulsion Stabilization
    Olasehinde Owoseni
    Department of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States
    Langmuir 31:13700-7. 2015
    ..The wettability of naturally occurring halloysite clay nanotubes (HNT) is successfully tuned by the selective carbonization of the negatively charged external HNT surface...
  101. pmc Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human Cells
    Melisa Guven
    Francis Crick Institute, Clare Hall Laboratory, South Mimms, Herts, UK
    J Invest Dermatol 135:2834-41. 2015
    ..Our findings emphasize that damage to DNA repair proteins, as well as to DNA itself, is likely to be an important contributor to skin cancer risk. ..

Research Grants84

  1. Progranulin, TDP-43 and Cell Death
    Leonard Petrucelli; Fiscal Year: 2013
    ..Our hypothesis is that loss of functional PGRN leads to loss of functional TDP-43, which leads to cell death. ..
  2. The Role of TDP-43 Phosphorylation in Protein Function and Neurodegeneration
    YOUHNA AYALA; Fiscal Year: 2013
    ..applicant): The overall goal of this project is to identify factors that regulate the function of the TAR DNA binding protein (TDP-43)...
  3. Regulation of EBV Latency by EBNA1
    Paul M Lieberman; Fiscal Year: 2013
    ..More detailed understanding of EBNA1 is further justified by its potential value as a target for therapeutic intervention in diseases and cancers associated with EBV latent infection. ..
  4. Epithelial differentiation in cornea
    Bogi Andersen; Fiscal Year: 2012
    ....
  5. Transcriptional regulation of enteroendocrine cell differentiation by NeuroD
    Andrew B Leiter; Fiscal Year: 2013
    ..Aim 1 will examine how NeuroD associates with Sp1, RREB1, and LSD1 at one its known targets, the secretin gene to form a multiprotein coactivator complex...
  6. ALS therapies and genomics for mutant TDP-43 and TLS/FUS
    Don W Cleveland; Fiscal Year: 2010
    ..New, very high through put DNA/RNA sequencing methods will be used to identify genes whose expression is altered by the mutations, thereby identifying new targets and approaches for devising a successful therapy for ALS. ..
  7. Epigenetic mechanisms of TDP43-mediated neurodegeneration
    Amit Berson; Fiscal Year: 2013
    ..These devastating diseases are characterized by the abnormal cytoplasmic accumulation of TDP-43, an RNA and DNA binding protein. Mutations in the TDP-43 coding gene (TARDBP) are found in rare forms of FTD and ALS, providing additional ..
  8. DETERMINATION OF NEURONAL FATES IN VISUAL CORTEX
    Susan K McConnell; Fiscal Year: 2013
    ..The goals of our research are to identify the genes that regulate neurogenesis in the visual cortex and to understand how they affect the formation of cortical circuitry. ..
  9. Inhibition of Stat3 and inflammatory cytokine production
    Lionel B Ivashkiv; Fiscal Year: 2013
    ..Notch and TLR signaling was integrated at the level of the DNA binding protein RBP-J...
  10. Small Molecule Probes for TAR DNA Binding Protein 43_TDP-43
    Allen B Reitz; Fiscal Year: 2012
    ..Both diseases are now linked a protein called TAR DNA binding protein 43 (TDP-43), which aggregates in the nerve cells of patients, and we propose to generate novel molecules ..
  11. Human Stem Cell Recombineering
    MELVYS VALLEDOR CEBALLOS; Fiscal Year: 2012
    ..For instance, the viral DNA binding protein protects the ssDNA recombination substrate from degradation by host nucleases...
  12. New players in immune function: identification through RNAi and micro-RNA screens
    Anjana Rao; Fiscal Year: 2010
    ..This important resource would be broadly available to the general scientific community. ..
  13. Genetic Analysis of T Cell Leukemogenesis
    Stephen J Brandt; Fiscal Year: 2013
    ..abstract_text> ..
  14. Defining Mechanisms of TDP-43 Ubiquitination for Quality Control and Aggregation
    ERIC BERNARD DAMMER; Fiscal Year: 2012
    ..diseases associated with degeneration of aging neurons involves a deficit in the degradation of the TAR DNA binding protein (TDP-43)...
  15. TDP-43 acetylation as a pathogenic modification in ALS &related proteinopathies
    TODD JONATHAN COHEN; Fiscal Year: 2013
    ..TAR DNA-binding protein of 43kD (TDP-43) is a nuclear RNA and DNA binding protein that becomes abnormally aggregated in the brain and spinal cord of most ALS patients as well as a subset of ..
  16. Novel immunotherapeutics for the management of otitis media due to H. influenzae
    Steven D Goodman; Fiscal Year: 2013
    ..expand upon studies that will explore the observed synergy between antibodies directed against IHF (a DNA binding protein) and other enzymes, antibodies and/or antibiotics, then apply our advanced understanding to the design and ..
  17. FORMATION OF THE DROSOPHILA SALIVARY GLAND
    Deborah J Andrew; Fiscal Year: 2013
    ..Each transcription factor plays major roles in different aspects of SG biogenesis. The winged helix DNA binding protein Fork head (Fkh) is required for SG survival, for morphogenesis and for maintaining expression of itself and ..
  18. Roles for TDP-43 and FUS in ALS Using Motor Neurons from Embryonic Stem Cells
    Dara Ditsworth; Fiscal Year: 2012
    ....
  19. MECHANISMS NEUROTROPHIN SIGNALING THROUGH P75 RECEPTOR
    Bruce D Carter; Fiscal Year: 2013
    ..The cleavage of p75 releases its intracellular domain (ICD) along with NRIF, a DNA binding protein, thereby facilitating NRIF translocation to the nucleus, which leads to apoptosis...
  20. FUS/TLS GAIN AND LOSS OF FUNCTION IN ALS: ANIMAL AND CELLULAR MODELS OF DISEASE
    NEIL ALAN SHNEIDER; Fiscal Year: 2013
    ....
  21. Signature-based chemical screening for DYT6 dystonia
    DAVID CRISTOPHER BRAGG; Fiscal Year: 2012
    ..The causative gene was recently identified as THAP1 which encodes a DNA binding protein, THAP1 (thanatos-associated protein [THAP] domain-containing apoptosis-associated protein- 1)...
  22. Molecular library screen for suppressors of FUS proteinopathy
    Frank P Shewmaker; Fiscal Year: 2013
    ..Our system offers a fast and inexpensive screening mechanism to find drug leads that may eventually be developed into therapeutics capable of reducing the neurodegeneration in ALS, FTLD and other disorders. ..
  23. NEUROGENESIS AND MIGRATION IN DEVELOPING CEREBRAL CORTEX
    Susan K McConnell; Fiscal Year: 2013
    ..abstract_text> ..
  24. Elucidating the Mechanisms Underlying Mutant TDP43-induced Neurodegeneration
    Sami Barmada; Fiscal Year: 2013
    ..of ALS and the most prevalent type of FTD share a common pathology marked by the deposition of the TAR DNA binding protein of 43 kDa (TDP-43)...
  25. Effect of ALS-causing Mutations on Binding of TDP43 and FUS to RNA in iMNs
    HELAINA JESSICA SKOP; Fiscal Year: 2013
    ..Mutations in two RNA binding proteins, TAR DNA binding protein 43 (TDP43) and Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS), cause some forms of familial ..
  26. Characterizing TDP-43 isoforms in neurodegenerative disease
    NICHOLAS THOMAS SEYFRIED; Fiscal Year: 2010
    ..The study of TDP-43 will provide deeper understanding into the pathogenesis of these diseases and potentially lead to novel therapeutic strategies. ..
  27. Progranulin: Mutation and Regulation in Neurodegenerative disease
    Rosa Rademakers; Fiscal Year: 2012
    ..Unveiling the genetic and molecular pathways regulating PGRN may also reveal novel therapeutic targets that can be exploited for therapeutic actions aimed at delaying the neurodegenerative disease process. ..
  28. Proteolytic cleavage regulates Foxp3 activity
    Engin Ozkaynak; Fiscal Year: 2010
    ..Foxp3 can affect many genes, by increasing or suppressing their expression. We have shown Foxp3 is cleaved at two sites and cells expressing the cleaved forms of Foxp3 function very differently, indicating potential in therapy. ..
  29. Phage Display Investigations of TDP-43
    RAYMOND PHILIP contact ROOS; Fiscal Year: 2010
    ..Together, this work may provide insight into why mutations of this protein cause ALS, and potentially provide a direction for treatment of sporadic and inherited ALS (as well as other neurodegenerative diseases). ..
  30. Development of retinal ganglion cell types
    David A Feldheim; Fiscal Year: 2013
    ....
  31. Hepatitis B virus replication and DDB1
    Betty L Slagle; Fiscal Year: 2013
    ..also involved in carcinogenesis We and others have shown that the interaction of HBx with cellular damaged DNA binding protein (DDB1) is critical for HBV replication...
  32. Progranulin, TAR DNA binding protein-43 and Cell Death
    Leonard Petrucelli; Fiscal Year: 2009
    ..Our hypothesis is that loss of functional PGRN leads to loss of functional TDP-43, which leads to cell death. ..
  33. Transcribing Activities in N4 Infected E. Coli
    LUCIA B B ROTHMAN-DENES; Fiscal Year: 2013
    ..N4 RNAPII mechanism of promoter recognition: N4 RNAPII uses a transcription factor N4gp2, a single-stranded DNA binding protein, to recognize its promoters, which are similar in position and length to yeast mitochondrial RNAP promoters...
  34. In vivo modeling of TDP-43 toxicity
    JADA M LEWIS; Fiscal Year: 2011
    ..Aim 2: To identify which aspects of TDP-43 proteinopathy may be targets for therapeutic intervention. ..
  35. TOX, a Novel Regulator of Thymocyte Selection
    JONATHAN G KAYE; Fiscal Year: 2013
    ....
  36. Elucidation of Novel Post-Translational Mechanisms That Regulate Notch Activity
    RYAN SCOTT UNDERWOOD; Fiscal Year: 2013
    ..By characterizing these two mechanisms, this proposal aims to increase the understanding of how the critical Notch pathway is regulated and potentially provide novel therapeutic strategies for diseases such as T-ALL. ..
  37. The mechanism linking traumatic brain injury to amyotrophic lateral sclerosis
    TERESA EVANS; Fiscal Year: 2013
    ..Interestingly, another protein, transactivation response or TAR DNA Binding Protein 43 (TDP-43), forms aggregates in both ALS and TBI which suggests that protein aggregation could be a ..
  38. Development of Novel Agents Targeting Genome Stability and Maintenance for Treati
    John J Turchi; Fiscal Year: 2013
    ..we will pursue the development and analysis of small molecule inhibitors (SMIs) of the human single-strand DNA binding protein replication protein A (RPA)...
  39. DNA-Binding Protein Discovery by the Combinatorial Method REPSA
    Michael van Dyke; Fiscal Year: 2013
    ..We expect our research to ultimately catalyze numerous studies by us and other laboratories leading to a better understanding of E. coli biology at a molecular level and provide a framework for similar studies in other organisms. ..
  40. Tumor Progression of Nuclear EGFR in Breast Cancer
    Mien Chie Hung; Fiscal Year: 2013
    ....
  41. Mechanism of the Transcriptional Response to Transition Metals
    MICHAEL THOMAS MARR; Fiscal Year: 2013
    ..MTF-1 is a sequence specific DNA binding protein that perceives the metal status of a cell and activates genes accordingly...
  42. Mitochondrial DNA Replisome: Mechanism, Structure and Physiology
    LAURIE SIMON KAGUNI; Fiscal Year: 2013
    ..Therefore, a clear understanding of mitochondrial biogenesis and energy production and how these processes are deregulated in common disease states, is essential to treating them effectively (and economically). ..
  43. Bacterial cell cycle control
    SUSAN THOMAS LOVETT; Fiscal Year: 2010
    ..Several genetic screens will explore the role of ObgE and the DNA binding protein, SeqA in the regulation of DNA replication and chromosome segregation...
  44. Intracellular Defenses Against Foreign DNA: Insights From Poxvirus-Infected Cells
    Matthew S Wiebe; Fiscal Year: 2013
    ..poxviral B1 kinase is essential for viral DNA replication because it is needed to inactivate the cellular DNA binding protein BAF (barrier to autointegration factor)...
  45. CONTROL OF SIMIAN VIRUS 40 AND CELLULAR DNA REPLICATION
    KATHERINE LOUISE FRIEDMAN; Fiscal Year: 2013
    ....
  46. Biochemical Insight of Hyperphosphorylation of Replication Protein A
    Yue Zou; Fiscal Year: 2010
    ..DNA damage has been widely implicated in human cancer induction. Human RPA, the major single-stranded DNA binding protein, is essential for all DNA metabolic pathways such as DNA replication, DNA repair, recombination and DNA ..
  47. NMR Studies of Protein Side-Chain Dynamics
    MARK A RANCE; Fiscal Year: 2012
    ..abstract_text> ..
  48. REGULATION OF TISSUE SPECIFIC GENE EXPRESSION
    Pamela K Geyer; Fiscal Year: 2012
    ..is to identify true insulators among thousands of binding sites and define parameters that shape a single DNA binding protein into a multi- functional regulator...
  49. Regulation of RPA Activity in DNA Repair
    James A Borowiec; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: We will understand the functional significance of RPA phosphorylation in the cellular response to DNA damage. The results from this work could lead to new threraputics to treat human cancers ..
  50. Localization of Recombination sites in E. coli
    Steven J Sandler; Fiscal Year: 2010
    ..It is further hypothesized that the interactions between RecA and the single-stranded DNA binding protein (SSB) are critical in this decision...
  51. PHOSPHATE ACTIVATION MECHANISMS
    Stephen J Benkovic; Fiscal Year: 2013
    ..and structure, the identity of their protein-protein contacts, their interactions with single-stranded DNA binding protein, their location relative to their DNA templates, their dynamic properties with respect to dissociation from ..
  52. GENETICS OF DELAYED PUBERTY
    Lawrence C Layman; Fiscal Year: 2013
    ..Recently, we identified mutations in the chromodomain helicase DNA binding protein-7 (CHD7) and nasal embryonic LHRH factor (NELF) genes in sporadic IHH/KS patients...
  53. Astrocyte Development and Reactive Gliosis
    Teri L Belecky-Adams; Fiscal Year: 2012
    ....
  54. GENETIC ASPECTS OF DNA METHYLATION
    Eric U Selker; Fiscal Year: 2012
    ..In humans, loss of a DNA methyltransferase (MTase) causes ICF syndrome, loss of the methyl- DNA binding protein MeCP2 causes Rett syndrome and abnormal methylation is associatedwith cancer. ...
  55. Multilevel Targeted Therapeutics Using Surface Functionalized Nanoparticles encap
    JILL STEINBACH; Fiscal Year: 2012
    ..2 (a DNA binding protein affecting virus replication) and nectin-1 (a host cell receptor protein integral to initial viral binding ..
  56. Amphetamine-Induced Transcriptional Plasticity in Striatal GABAergic Interneurons
    ANNE ELIZABETH WEST; Fiscal Year: 2013
    ..However we discovered that AMPH administration drives rapid and robust phosphorylation of the methyl-DNA binding protein MeCP2 at Ser421 (pMeCP2) in the NAc, and that this AMPH-induced phosphorylation occurs selectively in FSIs...
  57. Assay Development for Inhibitors of KSHV
    Paul M Lieberman; Fiscal Year: 2010
    ..LANA is a DNA binding protein required for viral replication and episome maintenance during latency...
  58. Regulatory Mechanisms Controlling Expression of P. gingivalis Surface Structures
    MARY ELLEN DAVEY; Fiscal Year: 2013
    ..During preliminary studies, we discovered that a gene with high similarity to the DNA binding protein HU (PG0121) is transcribed with the K- antigen capsule synthesis operon and that this "histone-like" ..
  59. A Conserved G-rich Region within Human TH Promoter Regulates Its Activity
    Soumitra Basu; Fiscal Year: 2011
    ..are tested against unfolding activity of human Replication Protein A (RPA), the most abundant single strand DNA binding protein in eukaryotes...
  60. Hepatoma derived growth factor and vascular smooth muscle cell proliferation
    Allen D Everett; Fiscal Year: 2010
    ..Second, we will test the hypotheses that HDGF is a DNA binding protein using NMR based structure/function analyses, functions as a transcriptional repressor binding to the ..
  61. HMGB1 and neutrophil efferocytosis.
    JAROSLAW WALDEMAR ZMIJEWSKI; Fiscal Year: 2012
    ....
  62. Regulation of Cocaine Reward and Reinforcement by MeCP2
    ANNE ELIZABETH WEST; Fiscal Year: 2013
    ..We have shown that genetically manipulating the expression of the methyl-DNA binding protein MeCP2 in specific regions of the adult striatum modulates the ability of cocaine and the related ..
  63. Tumor-cell-specific targets for combined hyperthermia and radiation effects
    Tej K Pandita; Fiscal Year: 2013
    ..simultaneous inactivation of telomerase and ATM, or its recently identified effector hSSB1 (a single-strand DNA binding protein essential for DNA damage detection and repair), synergize heat-mediated IR-induced tumor control? (3) Does ..
  64. Mechanisms of HbF Activation by Non-deletional HPFH
    Kenneth R Peterson; Fiscal Year: 2013
    ....
  65. Pin1-dependent telomere regulation in aging and Alzheimer's disease
    Tae Ho Lee; Fiscal Year: 2013
    ..These studies should provide novel insight into telomere maintenance during aging and AD, and might have novel implications for developing new therapies. ..
  66. Selective over expression of TDP-43 in APP/PS1 mice alters APP processing
    MICHAEL ANDRE GITCHO; Fiscal Year: 2013
    ..This in vivo model potentially could lead to the development of new therapeutics targeted at slowing the progression. ..
  67. Borrelia burdorferi Ebfc regulon
    Brian Stevenson; Fiscal Year: 2013
    ..Thus, our continued studies will focus efforts toward production of improved preventative and curative therapies for not only Lyme disease, but also many other significant human infectious diseases. ..
  68. Evolution of Telomere End Protection
    ROBERT ANTHONY HOM; Fiscal Year: 2013
    ..Aim 2 will track how the DNA binding protein Cdc13, and its subunits Stn1 and Ten1, has evolved in their recognition of telomeric DNA...
  69. Elucidating the Chemistry and Targets of Cross-linking by Endogenous DNA Damage
    Sarah C Shuck; Fiscal Year: 2013
    ..This investigation represents the first study to elucidate the interaction of OPdA with DNA-binding proteins. ..
  70. Development of a novel whole genome amplification method that mimics nature
    Huimin Kong; Fiscal Year: 2009
    ..utilizes multiple replication proteins including a primase/helicase, a DNA polymerase, a single-stranded DNA binding protein, and several other accessory proteins to achieve rapid and sensitive whole genome amplification...
  71. Development of a novel whole genome amplification method that mimics nature
    Huimin Kong; Fiscal Year: 2007
    ..utilizes multiple replication proteins including a primase/helicase, a DNA polymerase, a single- stranded DNA binding protein, and several other accessory proteins...
  72. Biochemical and Genetic Analysis of Notch Signaling
    Raphael Kopan; Fiscal Year: 2013
    ....
  73. ACTIVATION OF RNA POLYMERASE BY SSDNA BINDING PROTEIN
    LUCIA ROTHMAN DENES; Fiscal Year: 1999
    DESCRIPTION: The bacteriophage N4 single-stranded DNA binding protein (N4SSB) is essential for phage replication, recombination and, unexpectedly, late transcription...
  74. SSB PROTEINS AS ORGANIZERS OF DNA PRECURSOR BIOSYNTHESIS
    Christopher Mathews; Fiscal Year: 2001
    ..Characterization of the phosphorylation of SSB will explore the role of this modification on protein-protein and protein-DNA associations. ..
  75. RECOMBINATION IN VITRO: ENZYMOLOGY AND INTERMEDIATES
    CHARLES RADDING; Fiscal Year: 1993
    ..Only one other protein, E. coli single-stranded DNA binding protein (SSB) is known to participate directly with recA protein in pairing and strand exchange, but other enzymes ..
  76. REGULATION AND FUNCTION OF FIS IN E COLI
    Robert Osuna; Fiscal Year: 1999
    ..In Escherichia coli, the small DNA binding protein Fis is involved in an increasing number of cellular processes that include stimulation of site-specific DNA ..
  77. CELLULAR RESPONSES TO UV LIGHT IN ATAXIA TELANGIECTASIA
    Kathleen Dixon; Fiscal Year: 2007
    ..This improved understanding may ultimately lead to the development of strategies for preventing and/or treating diseases that are characterized by genomic instability and neurological defects. ..
  78. MITOCHONDRIAL DNA REPLICATION FIDELITY & CARDIAC DISEASE
    LAURIE KAGUNI; Fiscal Year: 1999
    ..This work will help establish the basic biochemical mechanisms involved in generating these altered forms, and also provide an animal model system to determine whether mtDNA mutations are a cause or a consequence of cardiac disease. ..
  79. NMR STRUCTURAL STUDIES OF CORE BINDING FACTOR B SUBUNIT
    John Bushweller; Fiscal Year: 2000
    ..Structure determination will be carried out using a combination of NOE and J-coupling data collected from multi- dimensional NMR spectra. ..
  80. Molecular Basis of mu-Opioid Receptor Gene Regulation
    Jane Ko; Fiscal Year: 2009
    ..underlying cell-specific MOR gene expression, especially focusing on the roles of single-stranded (ss) DNA binding protein and its functional interaction with double-stranded (ds) DNA binding proteins in MOR gene regulation...
  81. GENETIC AND BIOCHEMICAL ANALYSIS OF AD5 REGION 2
    GEOFFREY KITCHINGMAN; Fiscal Year: 1992
    ..The gene product of early region 2A is a 529 amino acid single-stranded DNA binding protein (DBP) that is involved in viral DNA replication, the host range of the virus, virus assembly, the ..
  82. STRUCTURAL STUDIES OF DNA REPLICATION AND REPAIR
    Gabriel Waksman; Fiscal Year: 2003
    ..Such structures will provide information on the mechanism of active unwinding by DNA-helicases and of passive unwinding by helix-destabilizing SSB proteins. ..
  83. Development of a protein-driven gene targeting technology
    Francesca Storici; Fiscal Year: 2010
    ..Aim 2) Generate DNA-protein complexes containing a site-specific DNA binding protein to drive the DNA template molecule to the targeting locus...
  84. FUNCTIONAL MAPPING OF NEUROENDOCRINE SYSTEMS
    Stephen Sagar; Fiscal Year: 1992
    ..Fos, the product of the c- fos gene, is a nuclear DNA binding protein which is synthesized by neurons in response to synaptic input...