RREB1

Summary

Gene Symbol: RREB1
Description: ras responsive element binding protein 1
Alias: FINB, HNT, LZ321, RREB-1, Zep-1, ras-responsive element-binding protein 1, DNA-binding protein, finger protein in nuclear bodies, hindsight homolog, raf-responsive zinc finger protein LZ321, zinc finger motif enhancer-binding protein 1
Species: human
Products:     RREB1

Top Publications

  1. Thiagalingam A, de Bustros A, Borges M, Jasti R, Compton D, Diamond L, et al. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. Mol Cell Biol. 1996;16:5335-45 pubmed
    ..These data suggest that RREB-1 may play a role in Ras and Raf signal transduction in medullary thyroid cancer and other cells. ..
  2. Milon B, Agyapong A, Bautista R, Costello L, Franklin R. Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells. Prostate. 2010;70:288-96 pubmed publisher
    ..The Ras pathway and activation of RREB-1 are involved in hZIP1 down-regulation and may play a role in the decrease of the transporter expression in prostate cancer. ..
  3. Chen R, Chou Y, Lan Y, Huang T, Shen C. Developmental silencing of human zeta-globin gene expression is mediated by the transcriptional repressor RREB1. J Biol Chem. 2010;285:10189-97 pubmed publisher
    ..suggest that repression of the human zeta-globin promoter is mediated through binding of the zinc finger factor RREB1 to ZF2...
  4. Yang Q, Köttgen A, Dehghan A, Smith A, Glazer N, Chen M, et al. Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. Circ Cardiovasc Genet. 2010;3:523-30 pubmed publisher
    ..significance with serum urate levels (P=4×10(-8) to 2×10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1)...
  5. Nitz M, Harding M, Smith S, Thomas S, Theodorescu D. RREB1 transcription factor splice variants in urologic cancer. Am J Pathol. 2011;179:477-86 pubmed publisher
    b>RREB1 is an alternatively spliced transcription factor implicated in Ras signaling and cancer. Little is known about the expression of RREB1 isoforms in cell lines or human tumors, or about the clinical relevance of the latter...
  6. Zhang S, Qian X, Redman C, Bliskovski V, Ramsay E, Lowy D, et al. p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB. Oncogene. 2003;22:2285-95 pubmed
    ..BALB/c mice have both regulatory and coding region defects that may contribute to the impairment of p16 gene function. ..
  7. Mukhopadhyay N, Cinar B, Mukhopadhyay L, Lutchman M, Ferdinand A, Kim J, et al. The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. Mol Endocrinol. 2007;21:2056-70 pubmed
    ..Collectively, our data for the first time identify RREB-1 as a repressor of AR and further implicate the Ras/MAPK kinase pathway as a likely antagonist of the inhibitory effects of RREB-1 on androgenic signaling. ..
  8. Liao P, Liao M, Li L, Tan B, Yin Y. Effect of deoxynivalenol on apoptosis, barrier function, and expression levels of genes involved in nutrient transport, mitochondrial biogenesis and function in IPEC-J2 cells. Toxicol Res (Camb). 2017;6:866-877 pubmed publisher
  9. Jiang Y, Li Z, Liu Y, Liu X, Chang Q, Liao Y, et al. Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms. J Ethnopharmacol. 2015;159:102-12 pubmed publisher

More Information

Publications137 found, 100 shown here

  1. McKee A, Stern R, Nowinski C, Stein T, Alvarez V, Daneshvar D, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013;136:43-64 pubmed publisher
  2. Senkevich T, Katsafanas G, Weisberg A, Olano L, Moss B. Identification of Vaccinia Virus Replisome and Transcriptome Proteins by Isolation of Proteins on Nascent DNA Coupled with Mass Spectrometry. J Virol. 2017;91: pubmed publisher
    ..The nascent DNA colocalized with the VACV single-stranded DNA binding protein I3 in multiple puncta throughout the interior of factories, which were surrounded by endoplasmic reticulum...
  3. Weidenbach K, Nickel L, Neve H, Alkhnbashi O, Künzel S, Kupczok A, et al. Methanosarcina Spherical Virus, a Novel Archaeal Lytic Virus Targeting Methanosarcina Strains. J Virol. 2017;91: pubmed publisher
    ..Moreover, the availability of a specific virus provides new possibilities to deepen our knowledge of the defense mechanisms of potential hosts and offers tools for genetic manipulation. ..
  4. Volonte C, Apolloni S, Parisi C. MicroRNAs: newcomers into the ALS picture. CNS Neurol Disord Drug Targets. 2015;14:194-207 pubmed
    ..C9ORF72), Cu/Zn superoxide dismutase (SOD1), fused in sarcoma/translocated in liposarcoma (FUS/TLS), TAR-DNA binding protein 43 (TDP43)...
  5. Moujalled D, Grubman A, Acevedo K, Yang S, Ke Y, Moujalled D, et al. TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway. Hum Mol Genet. 2017;26:1732-1746 pubmed publisher
    TAR DNA binding protein 43 (TDP-43) is a major disease-associated protein involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U)...
  6. Berjón Otero M, Lechuga A, Mehla J, Uetz P, Salas M, Redrejo Rodríguez M. Bam35 tectivirus intraviral interaction map unveils new function and localization of phage ORFan proteins. J Virol. 2017;: pubmed publisher
    ..We also detected interactions involving non-structural proteins, such as the DNA binding protein P1 and the genome terminal protein (P4), which was confirmed by co-immunoprecipitation of recombinant ..
  7. Tempera I, De Leo A, Kossenkov A, Cesaroni M, Song H, Dawany N, et al. Identification of MEF2B, EBF1, and IL6R as Direct Gene Targets of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Critical for EBV-Infected B-Lymphocyte Survival. J Virol. 2016;90:345-55 pubmed publisher
    Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the EBV-encoded nuclear antigen and sequence-specific DNA binding protein required for viral origin binding and episome maintenance during latency...
  8. Pearson J, Giogha C, Mühlen S, Nachbur U, Pham C, Zhang Y, et al. EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation. Nat Microbiol. 2017;2:16258 pubmed publisher
  9. Obulhasim G, Yasen M, Kajino K, Mogushi K, Tanaka S, Mizushima H, et al. Up-regulation of dbpA mRNA in hepatocellular carcinoma associated with metabolic syndrome. Hepatol Int. 2013;7:215-25 pubmed publisher
    ..The demethylation-related epigenetic activation may be one of the regulating factors for HCC patients with MS. ..
  10. Genbacev O, Larocque N, Ona K, Prakobphol A, Garrido Gomez T, Kapidzic M, et al. Integrin ?4-positive human trophoblast progenitors: functional characterization and transcriptional regulation. Hum Reprod. 2016;31:1300-14 pubmed publisher
    ..O., A.P., T.G.-G., M.K., A.B., M.G. have nothing to disclose. S.J.F. received licensing fees and royalties from SeraCare Life Sciences for trisomic TBPC lines that were derived according to the methods described in this manuscript. N/A. ..
  11. Yoshihara Hirata C, Yamashiro K, Yamamoto T, Aoyagi H, Ideguchi H, Kawamura M, et al. Anti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model. Infect Immun. 2018;86: pubmed publisher
  12. Plecha S, Withey J. Mechanism for inhibition of Vibrio cholerae ToxT activity by the unsaturated fatty acid components of bile. J Bacteriol. 2015;197:1716-25 pubmed publisher
    ..This differs from the inhibitory mechanism of a synthetic ToxT inhibitor, virstatin, which inhibits ToxT dimerization. Understanding the mechanisms for inhibition of virulence could lead to better cholera therapeutics. ..
  13. Cheng Z, Lin M, Rikihisa Y. Ehrlichia chaffeensis proliferation begins with NtrY/NtrX and PutA/GlnA upregulation and CtrA degradation induced by proline and glutamine uptake. MBio. 2014;5:e02141 pubmed publisher
    ..Our findings will advance the field's current conceptual paradigm on regulation of obligatory intracellular nutrition, metabolism, and growth. ..
  14. Brockman K, Azzari P, Branstool M, Atack J, Schulz B, Jen F, et al. Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae. MBio. 2018;9: pubmed publisher
    ..The findings of this work could be significant in the design of improved strategies against NTHI infections, as well as diseases due to other pathogens that utilize a phasevarion. ..
  15. MacNair L, Xiao S, Miletic D, Ghani M, Julien J, Keith J, et al. MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis. Brain. 2016;139:86-100 pubmed publisher
    ..This discovery-based approach has for the first time revealed translational changes in motor neurons of a TDP-43 mouse model, identifying DDX58 and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. ..
  16. Moujalled D, James J, Parker S, Lidgerwood G, Duncan C, Meyerowitz J, et al. Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress. PLoS ONE. 2013;8:e67433 pubmed publisher
    Abnormal processing of TAR DNA binding protein 43 (TDP-43) has been identified as a major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD)...
  17. Bianchi N, Cosenza L, Lampronti I, Finotti A, Breveglieri G, Zuccato C, et al. Structural and Functional Insights on an Uncharacterized Aγ-Globin-Gene Polymorphism Present in Four β0-Thalassemia Families with High Fetal Hemoglobin Levels. Mol Diagn Ther. 2016;20:161-73 pubmed publisher
    ..Additionally, we report evidence suggesting that the Aγ-globin gene +25(G→A) polymorphism decreases the efficiency of the interaction between this sequence and specific DNA binding protein complexes.
  18. Lu F, Wikramasinghe P, Norseen J, Tsai K, Wang P, Showe L, et al. Genome-wide analysis of host-chromosome binding sites for Epstein-Barr Virus Nuclear Antigen 1 (EBNA1). Virol J. 2010;7:262 pubmed publisher
    ..We conclude that EBNA1 can interact with a large number of cellular genes and chromosomal loci in latently infected cells, but that these sites are likely to represent a complex ensemble of direct and indirect EBNA1 binding sites. ..
  19. Kemp M. DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH). J Biol Chem. 2017;292:12424-12435 pubmed publisher
    ..inhibition of the XPB subunit of transcription factor IIH prevented the accumulation of the single-stranded DNA binding protein replication protein A (RPA) on damaged chromatin and severely abrogated ATR signaling in response to NA-AAF ..
  20. Kim T, Kim M, Lee J, Kim S, Je J, Lee Y, et al. CCCTC-binding factor controls the homeostatic maintenance and migration of Langerhans cells. J Allergy Clin Immunol. 2015;136:713-24 pubmed publisher
    ..Our results show that CTCF positively regulates the homeostatic pool and the efficient emigration of LCs, which are required for modulating the functional immune network of the skin. ..
  21. Matsumoto A, Suzuki H, Fukatsu R, Shimizu H, Suzuki Y, Hisanaga K. An autopsy case of frontotemporal lobar degeneration with the appearance of fused in sarcoma inclusions (basophilic inclusion body disease) clinically presenting corticobasal syndrome. Neuropathology. 2016;36:77-87 pubmed publisher
    ..Our case suggested further pathological heterogeneity in CBS than had previously been reported. It is necessary to consider FTLD-FUS (BIBD) as a background pathology for CBS in the future. ..
  22. Leyn S, Rodionova I, Li X, Rodionov D. Novel Transcriptional Regulons for Autotrophic Cycle Genes in Crenarchaeota. J Bacteriol. 2015;197:2383-91 pubmed publisher
    ..Novel regulons described for the first time in this work provide a basis for understanding the mechanisms of transcriptional regulation of autotrophic pathways in Archaea. ..
  23. Pardo E, Orejas M. The Aspergillus nidulans Zn(II)2Cys6 transcription factor AN5673/RhaR mediates L-rhamnose utilization and the production of α-L-rhamnosidases. Microb Cell Fact. 2014;13:161 pubmed publisher
    ..Gel mobility shift assays revealed RhaR to be a DNA binding protein recognizing a partially symmetrical CGG-X11-CCG sequence within the rhaA promoter...
  24. Quemin E, Pietilä M, Oksanen H, Forterre P, Rijpstra W, Schouten S, et al. Sulfolobus Spindle-Shaped Virus 1 Contains Glycosylated Capsid Proteins, a Cellular Chromatin Protein, and Host-Derived Lipids. J Virol. 2015;89:11681-91 pubmed publisher
  25. Coughlan K, Halang L, Woods I, Prehn J. A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43A315T mutant C57BL6/J mice. Dis Model Mech. 2016;9:1029-37 pubmed publisher
  26. Hayashi Y, Iwasaki Y, Takekoshi A, Yoshikura N, Asano T, Mimuro M, et al. An autopsy-verified case of FTLD-TDP type A with upper motor neuron-predominant motor neuron disease mimicking MM2-thalamic-type sporadic Creutzfeldt-Jakob disease. Prion. 2016;10:492-501 pubmed
    ..autopsy-verified case of frontotemporal lobar degeneration (FTLD)-transactivation responsive region (TAR) DNA binding protein (TDP) type A with upper motor neuron-predominant motor neuron disease mimicking MM2-thalamic-type sporadic ..
  27. Karas V, Westerlaken I, Meyer A. The DNA-Binding Protein from Starved Cells (Dps) Utilizes Dual Functions To Defend Cells against Multiple Stresses. J Bacteriol. 2015;197:3206-15 pubmed publisher
    ..Both biochemical activities are required to protect E. coli against stressors, as well as to protect DNA from oxidative damage in vitro. These results suggest that many stressors may cause both oxidative stress and direct DNA damage. ..
  28. Llewellyn K, Nalbandian A, Weiss L, Chang I, Yu H, Khatib B, et al. Myogenic differentiation of VCP disease-induced pluripotent stem cells: A novel platform for drug discovery. PLoS ONE. 2017;12:e0176919 pubmed publisher
    ..VCP disease phenotype is characterized by high expression of TAR DNA Binding Protein-43 (TDP-43), ubiquitin (Ub), Light Chain 3-I/II protein (LC3-I/II), and p62/SQSTM1 (p62) protein indicating ..
  29. Zou J, Milon B, Desouki M, Costello L, Franklin R. hZIP1 zinc transporter down-regulation in prostate cancer involves the overexpression of ras responsive element binding protein-1 (RREB-1). Prostate. 2011;71:1518-24 pubmed publisher
    ..RREB-1 overexpression results in down-regulation of hZIP1 and contributes to the loss of hZIP1 expression and zinc in prostate cancer. This is an early event in prostate carcinogenesis. ..
  30. Gulino R, Parenti R, Gulisano M. Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease. Biomed Res Int. 2015;2015:654637 pubmed publisher
    ..TDP-43 is a nuclear RNA/DNA binding protein involved in amyotrophic lateral sclerosis...
  31. Fahad S, Hussain S, Saud S, Tanveer M, Bajwa A, Hassan S, et al. A biochar application protects rice pollen from high-temperature stress. Plant Physiol Biochem. 2015;96:281-7 pubmed publisher
    ..Temperature treatments included high daytime temperature (HDT), high nighttime temperature (HNT) and ambient temperature (AT). The fertilization treatments were control, biochar alone, P alone and biochar + P...
  32. Kent O, Sandí M, Burston H, Brown K, Rottapel R. An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer. Oncotarget. 2017;8:4484-4500 pubmed publisher
    ..factors ELK1, ETS1, SP1 and SP3 and negatively regulated by the RAS responsive element binding protein (RREB1)...
  33. Ling X, Huang Q, Xu Y, Jin Y, Feng Y, Shi W, et al. The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development. FEBS Lett. 2017;591:875-888 pubmed publisher
    ..Moreover, genetic rescue experiments with the DNA binding protein Suppressor of Hairless or Notch RNAi indicate that they mediate the regulation of RTK signaling by Usp5...
  34. Arzate Mejía R, Recillas Targa F, Corces V. Developing in 3D: the role of CTCF in cell differentiation. Development. 2018;145: pubmed publisher
    ..We propose that the lineage-specific control of CTCF levels, and its partnership with lineage-specific transcription factors, allows for the control of cell type-specific gene expression via chromatin looping. ..
  35. Shi Y, Sawada J, Sui G, Affar E, Whetstine J, Lan F, et al. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature. 2003;422:735-8 pubmed
    ..These findings identify a molecular mechanism by which CtBP mediates transcriptional repression and provide insight into CtBP participation in oncogenesis. ..
  36. Endo S, Amano M, Nishimura N, Ueno N, Ueno S, Yuki H, et al. Immunomodulatory drugs act as inhibitors of DNA methyltransferases and induce PU.1 up-regulation in myeloma cells. Biochem Biophys Res Commun. 2016;469:236-42 pubmed publisher
    ..Collectively, IMiDs exert demethylation activity through inhibiting DNMT1, 3a, and 3b, and up-regulating PU.1 expression, which may be one of the mechanisms of the anti-myeloma activity of IMiDs. ..
  37. Konno T, Siuda J, Wszolek Z. Genetics of Parkinson's disease: a review of SNCA and LRRK2. Wiad Lek. 2016;69:328-32 pubmed
    ..The patients with LRRK2 mutations present with relatively typical PD phenotypes, but heterogeneous pathologies including ?-synuclein, tau, and occasionaly transactive response DNA-binding protein 43. ..
  38. Upton H, Chan H, Feigon J, Collins K. Shared Subunits of Tetrahymena Telomerase Holoenzyme and Replication Protein A Have Different Functions in Different Cellular Complexes. J Biol Chem. 2017;292:217-228 pubmed publisher
    ..These findings demonstrate that Tetrahymena telomerase holoenzyme and RPA complexes share subunits and that RPA subunits have distinct functions in different heterotrimer assemblies. ..
  39. Wobst H, Wesolowski S, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, et al. Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro. Front Mol Neurosci. 2017;10:46 pubmed publisher
  40. Shintaku M, Kaneda D, Oyanagi K. Novel intracytoplasmic inclusions immunoreactive for phosphorylated-TDP43 and cystatin C in anterior horn cells in a case of sporadic amyotrophic lateral sclerosis. Neuropathology. 2017;37:526-534 pubmed publisher
    ..Although their pathogenesis remains unknown, these unique inclusions may have been formed under a specific condition whereby p-TDP43 and cystatin C interacted with each other...
  41. Kim B, Irwin D, Song D, Daniel E, Leveque J, Raquib A, et al. Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration. Neurology. 2017;89:1604-1611 pubmed publisher
    ..7 vs 97.4 μm, p = 0.01) and EZ (14.4 vs 15.1 μm, p = 0.01) than controls. FTD is associated with outer retina thinning, and this thinning correlates with disease severity. ..
  42. Lee D, Ko J, Ji Y, Chung H, Hwang T. Proteomic identification of RREB1, PDE6B, and CD209 up-regulated in primitive gut tube differentiated from human embryonic stem cells. Pancreas. 2012;41:65-73 pubmed publisher
    ..These proteins were functionally annotated based on gene ontology. The expression levels of 3 proteins, RREB1, PDE6B, and CD209, involved in signal transduction, were validated using quantitative reverse transcription-..
  43. Wang F, Tidei J, Polich E, Gao Y, Zhao H, Perrone Bizzozero N, et al. Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis. Proc Natl Acad Sci U S A. 2015;112:E4995-5004 pubmed publisher
    ..Our results here reveal a novel positive feedback network between an RNA-binding protein and a transcription factor that plays critical regulatory roles in neurogenesis. ..
  44. Torrente M, Chuang E, Noll M, Jackrel M, Go M, Shorter J. Mechanistic Insights into Hsp104 Potentiation. J Biol Chem. 2016;291:5101-15 pubmed publisher
    ..Indeed, ATPase activity at NBD1 or NBD2 is sufficient for Hsp104 potentiation. Our findings will empower design of ameliorated therapeutic disaggregases for various neurodegenerative diseases. ..
  45. Newton K, Wickliffe K, Maltzman A, Dugger D, Strasser A, Pham V, et al. RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. 2016;540:129-133 pubmed publisher
    ..the RIP homotypic interaction motif (RHIM) in RIPK1 prevents the RHIM-containing adaptor protein ZBP1 (Z-DNA binding protein 1; also known as DAI or DLM1) from activating RIPK3 upstream of MLKL...
  46. Fantini D, Huang S, Asara J, Bagchi S, Raychaudhuri P. Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. Mol Biol Cell. 2017;28:192-200 pubmed publisher
    ..Together our results show that DDB2 is critical for chromatin association of XRCC5/6 in the absence of DNA damage and provide evidence that XRCC5/6 are functional partners of DDB2 in its transcriptional stimulatory activity. ..
  47. Bianco P, Pottinger S, Tan H, Nguyenduc T, Rex K, Varshney U. The IDL of E. coli SSB links ssDNA and protein binding by mediating protein-protein interactions. Protein Sci. 2017;26:227-241 pubmed publisher
    The E. coli single strand DNA binding protein (SSB) is essential to viability where it functions in two seemingly disparate roles: it binds to single stranded DNA (ssDNA) and to target proteins that comprise the SSB interactome...
  48. Romano R, Shon W, Sukov W. Malignant Melanoma of the Nail Apparatus: A Fluorescence In Situ Hybridization Analysis of 7 Cases. Int J Surg Pathol. 2016;24:512-8 pubmed publisher
    ..melanomas were analyzed by fluorescence in situ hybridization (FISH) using probes targeting the genes at 6p25 (RREB1), 11q13 (CCND1), 8q24.1 (MYC), 6q23 (MYB), 9p21 (CDKN2A) and the centromeres of chromosomes 8 (D8Z2) and 6 (D6Z1)...
  49. Durand A, Sinha A, Dard Dascot C, Michel B. Mutations Affecting Potassium Import Restore the Viability of the Escherichia coli DNA Polymerase III holD Mutant. PLoS Genet. 2016;12:e1006114 pubmed publisher
    ..ssb gene duplication, proposed to stabilize HolD-less Pol III HE by a modification of the single-stranded DNA binding protein (SSB) binding mode...
  50. Santamaria N, Alhothali M, Alfonso M, Breydo L, Uversky V. Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis. Cell Mol Life Sci. 2017;74:1297-1318 pubmed publisher
    Five structurally and functionally different proteins, an enzyme superoxide dismutase 1 (SOD1), a TAR-DNA binding protein-43 (TDP-43), an RNA-binding protein FUS, a cofilin-binding protein C9orf72, and polypeptides generated as a result ..
  51. Li Y, Li Z, Wu R, Han Z, Zhu W. And-1 is required for homologous recombination repair by regulating DNA end resection. Nucleic Acids Res. 2017;45:2531-2545 pubmed publisher
    ..These findings collectively demonstrate a hitherto unknown role of MDC1?And-1?CtIP axis that regulates CtIP-mediated DNA end resection and cellular response to DSBs. ..
  52. Irwin D, Lleo A, Xie S, McMillan C, Wolk D, Lee E, et al. Ante mortem cerebrospinal fluid tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration. Ann Neurol. 2017;82:247-258 pubmed publisher
    ..Autopsy-confirmed samples are critical for FTLD biomarker development and validation. Ann Neurol 2017;82:247-258. ..
  53. Costello L, Zou J, Desouki M, Franklin R. Evidence for changes in RREB-1, ZIP3, and Zinc in the early development of pancreatic adenocarcinoma. J Gastrointest Cancer. 2012;43:570-8 pubmed publisher
    ..This relationship constitutes a new concept of early genetic/metabolic events in the progressive transformation of normal cells to premalignant cells to malignant cells in the development of pancreatic cancer. ..
  54. Liptak C, Loria J. Movement and specificity in a modular DNA binding protein. Structure. 2015;23:973-4 pubmed publisher
    ..2015) show that the flexibility and interactions of the modular domains of RPA are altered by ssDNA binding and suggest that these changes in configurational freedom are important for the many functions of RPA. ..
  55. Chang X, Tan M, Tan L, Yu J. The Role of TDP-43 in Alzheimer's Disease. Mol Neurobiol. 2016;53:3349-3359 pubmed publisher
    The transactive response DNA binding protein (TDP-43) has long been characterized as a main hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U, also known as ..
  56. Gopal P, Nirschl J, Klinman E, Holzbaur E. Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons. Proc Natl Acad Sci U S A. 2017;114:E2466-E2475 pubmed publisher
    ..Mutations in the human RBPs TAR-DNA binding protein 43 (TDP-43) and RNA-binding protein FUS cause amyotrophic lateral sclerosis (ALS), but the biophysical ..
  57. Zhang Y, Fu L, Shu Z, Yang H, Tang A, Jiang T. Substitutional Doping for Aluminosilicate Mineral and Superior Water Splitting Performance. Nanoscale Res Lett. 2017;12:456 pubmed publisher
    ..This paper first designed an efficient lanthanum (La) doping strategy for nanotubular clay (halloysite nanotube, HNT) through the dynamic equilibrium of a substitutional atom in the presence of saturated AlCl3 solution, ..
  58. Ratti A, Buratti E. Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins. J Neurochem. 2016;138 Suppl 1:95-111 pubmed publisher
    ..played by RNA binding proteins in neurodegeneration have become apparent following the discovery of TAR DNA binding protein 43 kDa (TDP-43) and fused in sarcoma/translocated in liposarcoma (FUS/TLS) involvement in amyotrophic ..
  59. Liu J, Luo X, Xu Y, Gu J, Tang F, Jin Y, et al. Single-stranded DNA binding protein Ssbp3 induces differentiation of mouse embryonic stem cells into trophoblast-like cells. Stem Cell Res Ther. 2016;7:79 pubmed publisher
    ..In this study, we investigated the role of the single-stranded DNA binding protein, Ssbp3, for the induction of trophoblast-like differentiation from mouse ESCs...
  60. Ohta S, Yaguchi T, Okuno H, Chneiweiss H, Kawakami Y, Okano H. CHD7 promotes proliferation of neural stem cells mediated by MIF. Mol Brain. 2016;9:96 pubmed
    ..Collectively, our data demonstrate that CHD7 is an important factor in the proliferation and stemness maintenance of NSPCs, and CHD7 is a promising therapeutic target for the treatment of gliomas. ..
  61. Braak H, Del Tredici K. Anterior Cingulate Cortex TDP-43 Pathology in Sporadic Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol. 2018;77:74-83 pubmed publisher
    ..Some implications of the findings for the pathogenesis and progression of TDP-43 pathology in sALS are discussed. ..
  62. Akita M, Tak Y, Shimura T, Matsumoto S, Okuda Shimizu Y, Shimizu Y, et al. SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair. Sci Rep. 2015;5:10984 pubmed publisher
  63. Matthey N, Blokesch M. The DNA-Uptake Process of Naturally Competent Vibrio cholerae. Trends Microbiol. 2016;24:98-110 pubmed publisher
    ..cholerae, highlighting the presence of an extended competence-induced pilus and the contribution of a conserved DNA-binding protein that acts as a ratchet and reels DNA into the periplasm. ..
  64. Parakh S, Atkin J. Protein folding alterations in amyotrophic lateral sclerosis. Brain Res. 2016;1648:633-649 pubmed publisher
    ..are associated either genetically or pathologically in ALS, including superoxide dismutase 1 (SOD1), Tar DNA binding protein-43 (TDP-43), Ubiquilin-2, p62, VCP, and dipeptide repeat proteins produced by unconventional repeat ..
  65. Ooka M, Abe T, Cho K, Koike K, Takeda S, Hirota K. Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression. PLoS ONE. 2018;13:e0192421 pubmed publisher
    ..1), an SNF2 superfamily chromatin-remodeling factor also known as CHD1L (chromodomain helicase/ATPase DNA binding protein 1-like), is implicated in base-excision repair, where PARP (Poly(ADP-ribose) polymerase) mediated Poly(ADP-..
  66. Singh S, Narayanan S, Biswas K, Gupta A, Ahuja N, Yadav S, et al. Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect. Proc Natl Acad Sci U S A. 2017;114:11440-11445 pubmed publisher
    ..Our findings highlight the role of intragenic DNA methylation and DNA binding protein BORIS in cancer-specific splicing and its role in tumorigenesis.
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    Chromodomain helicase/ATPase DNA binding protein 1-like (CHD1L) gene is a newly identified oncogene located at Chr1q21 and it is amplified in many solid tumors...
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    ..Clinical presentation in AD is driven by pathological subtype, not by TDP-43. ..
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    ..Binuclear Ni(II) complexes (1-5) displayed significant protein (bovine serum albumin) interactions. The experimental results showed that the interaction between binuclear Ni(II) complexes and BSA was mainly a static quenching process. ..
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    ..We identified another CRYs-interacting protein, TAR DNA binding protein 43 (TDP-43), an RNA-binding protein...
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    Abnormal cytoplasmic mislocalization of transactive response DNA binding protein 43 (TARDBP or TDP-43) in degenerating neurons is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-..
  78. Feng W, Shao C, Liu H. Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and Disease. Front Mol Neurosci. 2017;10:309 pubmed publisher
    CHD7 (Chromo-Helicase-DNA binding protein 7) protein is an ATP-dependent chromatin remodeler. Heterozygous mutation of the CHD7 gene causes a severe congenital disease known as CHARGE syndrome...
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    ..This chapter reviews recent findings about the mechanisms underlying the efficiency, versatility, and accuracy of NER. ..
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    ..This study suggests the importance of MDP1-dependent simultaneous control of the cellular functions in the long-term survival of mycobacteria. ..
  82. Mishima T, Koga S, Lin W, Kasanuki K, Castanedes Casey M, Wszolek Z, et al. Perry Syndrome: A Distinctive Type of TDP-43 Proteinopathy. J Neuropathol Exp Neurol. 2017;76:676-682 pubmed publisher
    ..Dynactin p50 inclusions were observed in both Perry syndrome and HMN7B, but not in the other conditions. These results suggest that Perry syndrome may be distinctive type of TDP-43 proteinopathy. ..
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    ..9%), F-box and WD repeat domain containing 7 (FBXW7) (18.9%), chromodomain helicase DNA binding protein 4 (CHD4) (17.0%), and forkhead box A2 (FOXA2) (15.1%)...
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    ..It is intriguing that an operon regulated by AI-2 encodes functions resembling the ribose transporter, given recent findings that AI-2 is derived from the ribosyl moiety of S-ribosylhomocysteine...
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    ..These results indicated that SSDBP1 may induce cell chemoresistance of cisplatin through promoting DNA repair, resistance-related gene expression, cell proliferation, and inhibiting apoptosis. ..
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    ..In summary, the present study identified three DDR-associated genes as ZEB1 downstream targets, and demonstrated that their suppression by ZEB1 contributes to ZEB1-mediated chemoresistance. ..
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    Aggregation of TDP-43 (transactive response DNA binding protein 43?kDa) is a hallmark of certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD)...
  89. Huang S, Fantini D, Merrill B, Bagchi S, Guzman G, Raychaudhuri P. DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer. Cancer Res. 2017;77:6562-6575 pubmed publisher
    ..Our results identify DDB2 as both a partner and regulator of Wnt signaling, with an important role in suppressing colon cancer development. Cancer Res; 77(23); 6562-75. ©2017 AACR. ..
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    ..CedA, a double stranded DNA binding protein, interacts with various subunits of RNA polymerase complex, including rpoB...
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    ..Future studies will aim at determining the structural basis of these differences and thus help to gain a more comprehensive understanding of the functional divergences that these novel hSSBs display in the context of genome maintenance. ..
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