RREB1

Summary

Gene Symbol: RREB1
Description: ras responsive element binding protein 1
Alias: FINB, HNT, LZ321, RREB-1, Zep-1, DNA-binding protein, finger protein in nuclear bodies, hindsight homolog, raf-responsive zinc finger protein LZ321, ras-responsive element-binding protein 1, zinc finger motif enhancer binding protein 1, zinc finger motif enhancer-binding protein 1, zinc finger motif-enhancer binding-protein 1
Species: human

Top Publications

  1. doi RREB-1 is a transcriptional repressor of HLA-G
    Sébastien Flajollet
    Commissariat a l Energie Atomique, Direction des Sciences du Vivant, IBM, Service de Recherches en Hemato Immunologie, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    J Immunol 183:6948-59. 2009
  2. pmc RREB1 transcription factor splice variants in urologic cancer
    Matthew D Nitz
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    Am J Pathol 179:477-86. 2011
  3. pmc Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells
    Beatrice C Milon
    Department of Oncology and Diagnostic Sciences, Dental School, Greenebaum Cancer Center, University of Maryland Baltimore, Baltimore, MD 21201, USA
    Prostate 70:288-96. 2010
  4. ncbi DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter
    Hanshao Liu
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Biochem J 422:543-51. 2009
  5. pmc RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas
    A Thiagalingam
    Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Mol Cell Biol 16:5335-45. 1996
  6. pmc Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1
    Subir K Ray
    Division of Gastroenterology, GRASP Digestive Disease Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 23:259-71. 2003
  7. pmc Derepression of DNA damage-regulated genes requires yeast TAF(II)s
    B Li
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802 4500, USA
    EMBO J 19:4091-100. 2000
  8. pmc The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
    G S Brush
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 93:15075-80. 1996
  9. ncbi The Mfd protein of Bacillus subtilis 168 is involved in both transcription-coupled DNA repair and DNA recombination
    S Ayora
    , , E-28049, Madrid, Spain
    J Mol Biol 256:301-18. 1996
  10. ncbi Saccharomyces cerevisiae proteins involved in hybrid DNA formation in vitro
    W D Heyer
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
    Biochimie 73:269-76. 1991

Research Grants

  1. ALS therapies and genomics for mutant TDP-43 and TLS/FUS
    Don Cleveland; Fiscal Year: 2009
  2. ALS therapies and genomics for mutant TDP-43 and TLS/FUS
    Don W Cleveland; Fiscal Year: 2010
  3. Gamma Globin Induction: Molecular and Cell-Based Strategies
    BETTY SUE PACE; Fiscal Year: 2010
  4. GENETICS OF DELAYED PUBERTY
    Lawrence C Layman; Fiscal Year: 2010
  5. GENETICS OF DELAYED PUBERTY
    Lawrence C Layman; Fiscal Year: 2011
  6. GENETICS OF DELAYED PUBERTY
    Lawrence C Layman; Fiscal Year: 2013
  7. Regulation of EBV Latency by EBNA1
    Paul M Lieberman; Fiscal Year: 2013
  8. Astrocyte Development and Reactive Gliosis
    Teri L Belecky Adams; Fiscal Year: 2010
  9. Epithelial differentiation in cornea
    Bogi Andersen; Fiscal Year: 2009
  10. Transcriptional regulation of enteroendocrine cell differentiation by NeuroD
    Andrew B Leiter; Fiscal Year: 2010

Detail Information

Publications168 found, 100 shown here

  1. doi RREB-1 is a transcriptional repressor of HLA-G
    Sébastien Flajollet
    Commissariat a l Energie Atomique, Direction des Sciences du Vivant, IBM, Service de Recherches en Hemato Immunologie, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    J Immunol 183:6948-59. 2009
    ..This demonstration is the first of a repressor factor of HLA-G transcriptional activity taking part in HLA-G repression by epigenetic mechanisms...
  2. pmc RREB1 transcription factor splice variants in urologic cancer
    Matthew D Nitz
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    Am J Pathol 179:477-86. 2011
    b>RREB1 is an alternatively spliced transcription factor implicated in Ras signaling and cancer. Little is known about the expression of RREB1 isoforms in cell lines or human tumors, or about the clinical relevance of the latter...
  3. pmc Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells
    Beatrice C Milon
    Department of Oncology and Diagnostic Sciences, Dental School, Greenebaum Cancer Center, University of Maryland Baltimore, Baltimore, MD 21201, USA
    Prostate 70:288-96. 2010
    ..However, the mechanism of hZIP1 down-regulation is not known. We have hypothesized that hZIP1 is down-regulated through transcriptional regulation...
  4. ncbi DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter
    Hanshao Liu
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Biochem J 422:543-51. 2009
    ..We also show that, upon exposure to genotoxic stress, RREB-1 controls apoptosis in a p53-dependent manner. These findings provide evidence that RREB-1 participates in modulating p53 transcription in response to DNA damage...
  5. pmc RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas
    A Thiagalingam
    Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Mol Cell Biol 16:5335-45. 1996
    ..These data suggest that RREB-1 may play a role in Ras and Raf signal transduction in medullary thyroid cancer and other cells...
  6. pmc Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1
    Subir K Ray
    Division of Gastroenterology, GRASP Digestive Disease Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 23:259-71. 2003
    ..We identified by expression cloning the zinc finger protein RREB-1, also known to exist as a longer form, Finb, as the protein binding to one of the mutationally sensitive elements...
  7. pmc Derepression of DNA damage-regulated genes requires yeast TAF(II)s
    B Li
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802 4500, USA
    EMBO J 19:4091-100. 2000
    ..Our results indicate that yeast TAF(II)s have other functions in addition to core promoter selectivity, and describe a novel activity: the derepression of promoters...
  8. pmc The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
    G S Brush
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 93:15075-80. 1996
    ....
  9. ncbi The Mfd protein of Bacillus subtilis 168 is involved in both transcription-coupled DNA repair and DNA recombination
    S Ayora
    , , E-28049, Madrid, Spain
    J Mol Biol 256:301-18. 1996
    ..The Mfd protein is a sequence-independent DNA binding protein with weak ATPase activity. The Mfd protein was able to displace in vitro B. subtilis or E...
  10. ncbi Saccharomyces cerevisiae proteins involved in hybrid DNA formation in vitro
    W D Heyer
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
    Biochimie 73:269-76. 1991
    ..We have identified two proteins that functionally interact with SEP1. First, an Mr 34,000 single-stranded DNA binding protein stimulated the reaction by lowering the requirement for SEP1 about 3-4 fold...
  11. ncbi Role of the conserved carboxy-terminal alpha-helix of Rad6p in ubiquitination and DNA repair
    Y Dor
    Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Israel
    Mol Microbiol 21:1197-206. 1996
    ..Mutants affecting several functions of the 26S proteasome retain wild-type capacity for error-free DNA repair. This raises the possibility that ubiquitination by Rad6p in DNA repair does not target proteins for proteasomal degradation...
  12. ncbi Evidence for nucleosomal phasing and a novel protein specifically binding to cucumber satellite DNA
    T C Fischer
    , Biologisches Institut, , Bundesrepublik Deutschland
    Z Naturforsch C 49:79-86. 1994
    ..For the first time in plants, a satellite DNA-binding protein with an apparent molecular weight of 14 kDa (SAT 14) was identified...
  13. pmc Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinase
    L J Blackwell
    Department of Biochemistry, New York University Medical Center, New York 10016, USA
    Mol Cell Biol 16:4798-807. 1996
    ..Our results indicate that hRPA binds ssDNA in a multistep pathway, inducing new hRPA alignments and conformations that can modulate the functional interaction of other factors with hRPA...
  14. ncbi Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution
    D K Worthylake
    Biochemistry Department, University of Utah, Salt Lake City, Utah 84132, USA
    J Biol Chem 273:6271-6. 1998
    ..via interaction with the ubiquitin-protein ligase Ubr1 and in DNA repair via interactions with the DNA binding protein Rad18. We report here the crystal structure of Rad6 refined at 2.6 A resolution to an R factor of 21.3%...
  15. ncbi Coordinated leading- and lagging-strand synthesis at the Escherichia coli DNA replication fork. III. A polymerase-primase interaction governs primer size
    E L Zechner
    Graduate Program in Molecular Biology, Cornell University Graduate School of Medical Sciences, New York, New York 10021
    J Biol Chem 267:4054-63. 1992
    ..form II DNA template, the DNA polymerase III holoenzyme (Pol III HE), the Escherichia coli single-stranded DNA binding protein, and the primosome, showed that within the context of a replication fork, the oligoribonucleotide primers ..
  16. pmc Colocalization of baculovirus IE-1 and two DNA-binding proteins, DBP and LEF-3, to viral replication factories
    K Okano
    Laboratory of Molecular Entomology and Baculovirology, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama, Japan
    J Virol 73:110-9. 1999
    ..These results suggested that there are about 15 preexisting sites per nucleus which are associated with the initiation of viral DNA replication and assembly of viral DNA replication factories...
  17. ncbi Analysis of a novel DNA-binding protein kinase CKII-like enzyme of Chironomus cells
    J Stigare
    Karolinska Institutet, Department of Cell and Molecular Biology, Laboratory of Medical Cell Biology, Stockholm, Sweden
    Cell Mol Biol Res 40:463-72. 1994
    ..The biochemical and immunological data taken together strongly suggest that CK42 is a novel DNA-binding protein kinase that is not the alpha subunit of CKII...
  18. pmc The single-stranded DNA-binding protein of Deinococcus radiodurans
    Julie Malia Eggington
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    BMC Microbiol 4:2. 2004
    ..Immediately upstream of the ssb gene is another gene (DR0099) given an ssb-like annotation, but left unexplored...
  19. ncbi The putative DNA-binding protein Sto12a from the thermoacidophilic archaeon Sulfolobus tokodaii contains intrachain and interchain disulfide bonds
    Akeo Shinkai
    RIKEN SPring 8 Center, Harima Institute, 1 1 1 Kouto, Sayo, Hyogo 679 5148, Japan
    J Mol Biol 372:1293-304. 2007
    ..This is a novel fold among winged-helix DNA-binding proteins. Possible DNA-binding interactions of the Sto12a protein are discussed based on the crystal structure of Sto12a and comparisons to other winged-helix DNA-binding proteins...
  20. ncbi [Recent progress in mycobacteriology]
    Masaji Okada
    Clinical Research Center, National Hospital Organization Kinki chuo Chest Medical Center, Japan
    Kekkaku 82:783-99. 2007
    ..These data indicate that our novel DNA vaccine might be useful against TB for human clinical trials...
  21. ncbi Contribution of a salt bridge to the thermostability of DNA binding protein HU from Bacillus stearothermophilus determined by site-directed mutagenesis
    S Kawamura
    Laboratory of Biochemistry, Faculty of Agriculture, Kyushu University, Higashi ku, Fukuoka
    J Biochem 121:448-55. 1997
    ..Glu34, Arg37, and Lys38, to the thermostability of the thermophilic protein, Bacillus stearothermophilus DNA binding protein HU (BstHU), relative to the mesophilic homologue, Bacillus subtilis HU (BsuHU)...
  22. ncbi Structural and functional studies of the rat mitochondrial single strand DNA binding protein P16
    G D Hoke
    Department of Biochemistry and Molecular Biophysics, Virginia Commonwealth University, Richmond 23298
    Arch Biochem Biophys 282:116-24. 1990
    The rat mitochondrial single strand DNA binding protein (SSB) P16 was purified to apparent homogeneity by elution from single strand DNA agarose with ethidium bromide...
  23. pmc Characterization of a baculovirus lacking the DBP (DNA-binding protein) gene
    Adam L Vanarsdall
    Department of Microbiology, Nash Hall Room 220, Oregon State University, Corvallis, OR 97331 3804, USA
    Virology 364:475-85. 2007
    ..Finally, immunoelectron microscopic analysis of cells transfected with the dbp knockout revealed that DBP is required for the production of normal-appearing nucleocapsids and for the generation of the virogenic stroma...
  24. ncbi Sub-speciating Campylobacter jejuni by proteomic analysis of its protein biomarkers and their post-translational modifications
    Clifton K Fagerquist
    Western Regional Research Center, Agricultural Research Service, United States Department of Agriculture, 800 Buchanan Street, Albany, California 94710, USA
    J Proteome Res 5:2527-38. 2006
    ....
  25. pmc Structural studies of bacteriophage alpha3 assembly
    Ricardo A Bernal
    Department of Biological Sciences, Purdue University, 1392 Lilly Hall, West Lafayette, IN 47907 1392, USA
    J Mol Biol 325:11-24. 2003
    ..The icosahedrally ordered structural component of the ssDNA appears to be substantially increased in alpha3 compared to phiX174, allowing the building of about 10% of the ribose-phosphate backbone...
  26. pmc Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies
    Kunihiro Uryu
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 67:555-64. 2008
    ..These findings provide further insight into the burden and clinical significance of TDP-43 pathology in disorders other than FTLD-U and amyotrophic lateral sclerosis...
  27. ncbi Differential interaction of the dual alpha tropomyosin/N5 enhancer with multiple DNA binding proteins: N5 is a putative novel z-ZIP DNA binding protein
    N Ruiz-Opazo
    Section of Molecular Genetics, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118
    Cell Mol Biol Res 40:265-72. 1994
    ..with a particular enhancer modular sequence (delimited to 18 bp- to 38 bp-long); and that likewise, a DNA binding protein can bind specifically to different DNA enhancer modular sequences with apparent different affinities...
  28. pmc Strand displacement by DNA polymerase III occurs through a tau-psi-chi link to single-stranded DNA-binding protein coating the lagging strand template
    Quan Yuan
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA
    J Biol Chem 284:31672-9. 2009
    ..is distinguished from the single-stranded DNA-templated reaction by a high dependence upon single-stranded DNA binding protein and an inability of gamma-complex to support the reaction in the absence of tau...
  29. ncbi Two types of localization of the DNA-binding proteins within the Escherichia coli nucleoid
    T A Azam
    Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Genes Cells 5:613-26. 2000
    ..The intracellular localization of these proteins in E. coli could be predicted from these data, but no attempt has been made thus far to directly observe the intracellular distribution of the DNA-binding proteins...
  30. pmc CC1, a novel crenarchaeal DNA binding protein
    Xiao Luo
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, UK
    J Bacteriol 189:403-9. 2007
    ..crenarchaea Pyrobaculum aerophilum and Thermoproteus tenax lack any obvious gene encoding a single-stranded DNA binding protein (SSB)...
  31. pmc Role of the adenovirus DNA-binding protein in in vitro adeno-associated virus DNA replication
    P Ward
    Department of Microbiology, Hearst Microbiology Research Center, Cornell University Medical College, New York, New York 10021, USA
    J Virol 72:420-7. 1998
    ..Extracts supplemented with Ad-DBP preferentially replicated AAV sequences rather than adjacent vector sequences; in contrast, extracts supplemented with RPA preferentially replicated vector sequences...
  32. ncbi Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders
    J N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 32:1157-65. 2001
    ..These data also indicate that multilayered epithelium is phenotypically similar to, and may share a lineage relationship with, mucosal gland duct epithelium...
  33. ncbi Isolation and characterization of the gene encoding single-stranded-DNA-binding protein (SSB) from four marine Shewanella strains that differ in their temperature and pressure optima for growth
    L N Chilukuri
    Center for Marine Biotechnology and Biomedicine, Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla 92093 0202, USA
    Microbiology 143:1163-74. 1997
    ..The differences found among the Shewanella SSBs suggest that these proteins will provide a useful system for exploring the adaptation of protein-protein and protein-DNA interactions at low temperature and high pressure...
  34. pmc Bombyx mori nucleopolyhedrovirus encodes a DNA-binding protein capable of destabilizing duplex DNA
    V S Mikhailov
    N K Koltzov Institute of Developmental Biology, Moscow, Russia
    J Virol 72:3107-16. 1998
    ..This helix-destabilizing ability is consistent with the prediction that DBP functions as a single-stranded DNA binding protein in virus replication.
  35. pmc Escherichia coli single-stranded DNA-binding protein mediates template recycling during transcription by bacteriophage N4 virion RNA polymerase
    Elena K Davydova
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 100:9250-5. 2003
    ..No sequence similarity to this domain exists in vRNAP. Hereby, we propose a unique role for EcoSSB: It functionally substitutes in N4 vRNAP for the N-terminal domain of T7 RNAP responsible for RNA binding...
  36. doi Induction of paranodal myelin detachment and sodium channel loss in vivo by Campylobacter jejuni DNA-binding protein from starved cells (C-Dps) in myelinated nerve fibers
    Hua Piao
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurol Sci 288:54-62. 2010
    ..Thus, we consider that C-Dps damages myelinated nerve fibers, possibly through interference with paranodal sulfatide function, and may contribute to the axonal pathology seen in C. jejuni-related GBS...
  37. ncbi Structural analysis of the chromosome segregation protein Spo0J from Thermus thermophilus
    Thomas A Leonard
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Mol Microbiol 53:419-32. 2004
    ..We hypothesize that the C-terminus mediates dimerization of Spo0J, thereby effectively increasing the local concentration of the N-termini, which most probably dimerize, as shown by our structure, upon binding to a cognate parS site...
  38. pmc Isolation and characterization of the DNA-binding protein (DBP) of the Autographa californica multiple nucleopolyhedrovirus
    Victor S Mikhailov
    Department of Microbiology, Oregon State University, Corvallis, OR 97331 3804, USA
    Virology 370:415-29. 2008
    ..These activities and a tight association with subnuclear structures suggests that DBP is a component of the virogenic stroma that is involved in the processing of replicative intermediates...
  39. ncbi Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene
    J A Menendez
    Department of Medicine, Breast Cancer Translational Research Program, Evanston Northwestern Healthcare Research Institute, Evanston, IL, USA
    Ann Oncol 16:1253-67. 2005
    ..FAS (oncogenic antigen-519) is up-regulated in about 50% of breast cancers, is an indicator of poor prognosis, and has recently been functionally associated with the Her2/neu (erbB-2) oncogene...
  40. pmc Functional roles of the N- and C-terminal regions of the human mitochondrial single-stranded DNA-binding protein
    Marcos T Oliveira
    Department of Biochemistry and Molecular Biology, Center for Mitochondrial Science and Medicine, and Graduate Program in Genetics, Michigan State University, East Lansing, Michigan, United States of America
    PLoS ONE 5:e15379. 2010
    ..We discuss our findings in the context of species-specific components of the mtDNA replisome, and in comparison with various prokaryotic DNA replication machineries...
  41. pmc Identification and characterization of a phase-specific, nuclear DNA binding protein from the dimorphic pathogenic fungus Histoplasma capsulatum
    F E Abidi
    Center for Molecular Studies, J C Self Research Institute, Greenwood Genetics Center, Greenwood, South Carolina 29646, USA
    Infect Immun 66:3867-73. 1998
    ..capsulatum which binds to target sequences in a phase-specific manner, suggesting that p30M may govern aspects of gene transcription in this pathogenic fungus, in which a temperature-sensitive switch influences morphology and virulence...
  42. ncbi Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43
    Yvonne Davidson
    Clinical Neuroscience Research Group, Division of Medicine and Neuroscience, Greater Manchester Neurosciences Centre, Hope Hospital, University of Manchester, Salford, M6 8HD, UK
    Acta Neuropathol 113:521-33. 2007
    ..We conclude that the UBQ-ir lesions of FTLD and MND are defined by the presence of TDP-43, and that these disorders can be subsumed into a single disease entity under the umbrella of TDP-43 proteinopathy...
  43. pmc Biochemical interaction of the Escherichia coli RecF, RecO, and RecR proteins with RecA protein and single-stranded DNA binding protein
    K Umezu
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 90:3875-9. 1993
    ..As shown by other workers, joint molecule formation by RecA was inhibited by E. coli single-stranded DNA binding protein (SSB) when it was added to single-stranded DNA before RecA...
  44. pmc A novel class of plant-specific zinc-dependent DNA-binding protein that binds to A/T-rich DNA sequences
    Y Nagano
    Graduate School of Agricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Nucleic Acids Res 29:4097-105. 2001
    ..These results indicate that PLATZ1 is a novel class of plant-specific zinc-dependent DNA-binding protein responsible for A/T-rich sequence-mediated transcriptional repression...
  45. pmc The AcMNPV pp31 gene is not essential for productive AcMNPV replication or late gene transcription but appears to increase levels of most viral transcripts
    Junya Yamagishi
    Boyce Thompson Institute at Cornell University, Ithaca, NY 14853, USA
    Virology 365:34-47. 2007
    The pp31 gene of Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) encodes a phosphorylated DNA binding protein that associates with virogenic stroma in the nuclei of infected cells...
  46. ncbi A postsynaptic role for single-stranded DNA-binding protein in recA protein-promoted DNA strand exchange
    P E Lavery
    Department of Cell, Molecular, and Structural Biology, Northwestern University Medical School, Chicago, Illinois 60611
    J Biol Chem 267:9315-20. 1992
    ....
  47. ncbi Temperature-sensitive mutants of adenovirus single-stranded DNA-binding protein. Inability to support DNA replication is associated with an altered DNA-binding activity of the protein
    M Tsuji
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38101
    J Biol Chem 266:16178-87. 1991
    ..Thus, the inability of these three ts DBPs to support DNA replication is attributable to their altered DNA-binding properties...
  48. pmc Binding of the dimeric Deinococcus radiodurans single-stranded DNA binding protein to single-stranded DNA
    Alexander G Kozlov
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Biochemistry 49:8266-75. 2010
    Deinococcus radiodurans single-stranded (ss) DNA binding protein (DrSSB) originates from a radiation-resistant bacterium and participates in DNA recombination, replication, and repair...
  49. pmc A DNA-binding peroxiredoxin of Coxiella burnetii is involved in countering oxidative stress during exponential-phase growth
    Linda D Hicks
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA
    J Bacteriol 192:2077-84. 2010
    ..Taken as a whole, the results show that Coxiella BCP binds DNA and likely serves to detoxify endogenous hydroperoxide byproducts of Coxiella's metabolism during intracellular replication...
  50. pmc Growth phase-dependent variation in protein composition of the Escherichia coli nucleoid
    T Ali Azam
    Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    J Bacteriol 181:6361-70. 1999
    ..These changes in the composition of nucleoid-associated proteins in the stationary phase are accompanied by compaction of the genome DNA and silencing of the genome functions...
  51. ncbi Mechanism of stimulation of DNA replication by bacteriophage phi 29 single-stranded DNA-binding protein p5
    C Gutierrez
    Centro de Biologia Molecular CSIC UAM, Canto Blanco, Madrid, Spain
    J Biol Chem 266:2104-11. 1991
    ..Our results strongly suggest that phi 29 protein p5 is the phi 29 SSB protein active during phi 29 DNA replication...
  52. ncbi Cloning, sequencing and expression of the two genes encoding the mitochondrial single-stranded DNA-binding protein in Xenopus laevis
    A M Champagne
    Centre de Genetique Moleculaire, CNRS, Gif sur Yvette, France
    Gene 184:65-71. 1997
    In Xenopus laevis the single-stranded DNA binding protein imported into the mitochondria consists of two highly related polypeptides...
  53. ncbi The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity
    P Beatus
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Mech Dev 104:3-20. 2001
    ..The interplay between the RE/AC region and the ankyrin repeat region provides a basis to understand the difference in HES activation between structurally similar Notch receptors...
  54. ncbi Mitochondrial single-stranded DNA-binding protein from Drosophila embryos. Physical and biochemical characterization
    P Thommes
    Marie Curie Research Institute, Oxted, Surrey, United Kingdom
    J Biol Chem 270:21137-43. 1995
    ..The homogeneous protein stimulates the activity of mitochondrial DNA polymerase from D. melanogaster embryos, increasing dramatically the rate of initiation of DNA synthesis on a singly primed DNA template...
  55. doi Orchestration of Haemophilus influenzae RecJ exonuclease by interaction with single-stranded DNA-binding protein
    Ruchika Sharma
    Department of Biochemistry, Indian Institute of Science, Bangalore, India
    J Mol Biol 385:1375-96. 2009
    ..In addition, these results implicate SSB as being involved in the recruitment of RecJ to DNA and provide insights into the interplay between these proteins in repair and recombination pathways...
  56. pmc C-terminal phenylalanine of bacteriophage T7 single-stranded DNA-binding protein is essential for strand displacement synthesis by T7 DNA polymerase at a nick in DNA
    Sharmistha Ghosh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 284:30339-49. 2009
    ..gp2.5 lacking the C-terminal phenylalanine does not support this event with wild-type DNA polymerase but does to a limited extent with T7 DNA polymerase harboring the suppressor mutations...
  57. pmc The C6 zinc finger and adjacent amino acids determine DNA-binding specificity and affinity in the yeast activator proteins LAC9 and PPR1
    M M Witte
    Department of Biochemistry, University of Kentucky, Lexington 40536 0084
    Mol Cell Biol 10:5128-37. 1990
    ....
  58. pmc Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha
    S J Froelich-Ammon
    Department of Chemistry and Biochemistry and Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309 0215, USA
    Genes Dev 12:1504-14. 1998
    ..We conclude that the telomere protein inhibits telomerase by rendering the telomeric DNA inaccessible, thereby helping to maintain telomere length...
  59. ncbi Crystal structure of the chi:psi sub-assembly of the Escherichia coli DNA polymerase clamp-loader complex
    Jacqueline M Gulbis
    Laboratory of Molecular Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA
    Eur J Biochem 271:439-49. 2004
    ..The base of the clamp-loader complex has an open C-shaped structure, and the shape of the chi:psi complex is suggestive of a loose docking within the crevice formed by the open faces of the delta and delta' subunits of the clamp-loader...
  60. ncbi carP, involved in pyrimidine regulation of the Escherichia coli carbamoylphosphate synthetase operon encodes a sequence-specific DNA-binding protein identical to XerB and PepA, also required for resolution of ColEI multimers
    D Charlier
    Research Institute of the CERIA COOVI, Brussels, Belgium
    J Mol Biol 250:392-406. 1995
    ..We propose that integration host factor and CarP/PepA-induced structural modifications in the carAB control region cause conformational changes required to assemble a pyrimidine-specific nucleo-protein regulatory complex...
  61. pmc Binding specificity of Escherichia coli single-stranded DNA binding protein for the chi subunit of DNA pol III holoenzyme and PriA helicase
    Alexander G Kozlov
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Biochemistry 49:3555-66. 2010
    The Escherichia coli single-stranded DNA binding protein (SSB) plays a central role in DNA metabolism through its high affinity interactions with ssDNA, as well as its interactions with numerous other proteins via its unstructured C-..
  62. ncbi Regulation of mitochondrial single-stranded DNA-binding protein gene expression links nuclear and mitochondrial DNA replication in drosophila
    I Ruiz de Mena
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824 1319, USA
    J Biol Chem 275:13628-36. 2000
    ..Our data suggest strongly that the Drosophila mtSSB gene is regulated by the DRE/DREF system. This finding represents a first link between nuclear and mitochondrial DNA replication...
  63. ncbi Helix-destabilizing properties of the baculovirus single-stranded DNA-binding protein (LEF-3)
    V S Mikhailov
    Kol tsov Institute of Developmental Biology, Moscow, 117808, Russia
    Virology 270:180-9. 2000
    ..15 M NaCl. Therefore, the polar destabilization effect of LEF-3 seems to be physiologically important and may be connected, in particular, with the polar action of viral helicase holoenzyme during baculovirus replication...
  64. ncbi Structural and functional analysis of the baculovirus single-stranded DNA-binding protein LEF-3
    Victor S Mikhailov
    Department of Microbiology, Oregon State University, Nash Hall 220, Corvallis, OR 97331 3804, USA
    Virology 346:469-78. 2006
    ..The unfolded LEF-3 was active in a strand exchange reaction suggesting that it could be involved in the production of recombination intermediates...
  65. pmc Zuotin, a putative Z-DNA binding protein in Saccharomyces cerevisiae
    S Zhang
    Department of Biology 16 739, Massachusetts Institute of Technology, Cambridge 02139
    EMBO J 11:3787-96. 1992
    A putative Z-DNA binding protein, named zuotin, was purified from a yeast nuclear extract by means of a Z-DNA binding assay using [32P]poly(dG-m5dC) and [32P]oligo(dG-Br5dC)22 in the presence of B-DNA competitor...
  66. pmc A role for the human single-stranded DNA binding protein HSSB/RPA in an early stage of nucleotide excision repair
    D Coverley
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK
    Nucleic Acids Res 20:3873-80. 1992
    The human single-stranded DNA binding protein (HSSB/RPA) is involved in several processes that maintain the integrity of the genome including DNA replication, homologous recombination, and nucleotide excision repair of damaged DNA...
  67. pmc TDP-43 in aging and Alzheimer's disease - a review
    Andrea C Wilson
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Int J Clin Exp Pathol 4:147-55. 2011
    Transactive response DNA-binding protein of 43 kDa (TDP-43), an RNA and DNA binding protein involved in transcriptional repression, RNA splicing and RNA metabolism during the stress response, is the major component of neuronal inclusions ..
  68. pmc Direct stimulus perception and transcription activation by a membrane-bound DNA binding protein
    Susanne Gebhard
    Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, New Zealand
    Mol Microbiol 73:482-91. 2009
    ..The bacitracin resistance regulator, BcrR, of Enterococcus faecalis is a membrane-bound DNA binding protein and is required for bacitracin-dependent expression of the bacitracin resistance genes, bcrABD...
  69. pmc Anaplasma phagocytophilum p44 mRNA expression is differentially regulated in mammalian and tick host cells: involvement of the DNA binding protein ApxR
    Xueqi Wang
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    J Bacteriol 189:8651-9. 2007
    ..Interestingly, transcription of the A. phagocytophilum gene encoding the DNA binding protein ApxR was also significantly greater in A...
  70. pmc Gel shift analysis of the empA promoter region in Vibrio anguillarum
    Steven M Denkin
    Department of Cell and Molecular Biology, University of Rhode Island, Kingston, RI 02881, USA
    BMC Microbiol 4:42. 2004
    ..anguillarum, M93Sm and NB10. It is hypothesized that differences in empA regulation are due to differences in binding of regulatory elements...
  71. ncbi Superhelical path of the DNA in the nucleoprotein complex that activates the initiation of phage phi 29 DNA replication
    M Serrano
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Canto Blanco, Madrid, Spain
    J Mol Biol 230:248-59. 1993
    ..5 bp/turn) and strongly bent (66 degrees/12 bp). These DNA conformational changes might contribute to the activation of phi 29 DNA initiation of replication by protein p6...
  72. pmc Poly-A Binding Protein-1 Localization to a Subset of TDP-43 Inclusions in Amyotrophic Lateral Sclerosis Occurs More Frequently in Patients Harboring an Expansion in C9orf72
    Leeanne McGurk
    From the Department of Biology, University of Pennsylvania LM, NMB Translational Neuropathology Research Laboratory, Stellar Chance Laboratories EBL and Department of Pathology and Laboratory Medicine, Perelman School of Medicine VML, JQT, VMVD, EBL, Philadelphia, Pennsylvania
    J Neuropathol Exp Neurol 73:837-45. 2014
    ..In almost all cases of ALS, transactive response DNA binding protein of 43 kDa (TDP-43) forms cytoplasmic neuronal inclusions...
  73. pmc A Model for the Evolution of Biological Specificity: a Cross-Reacting DNA-Binding Protein Causes Plasmid Incompatibility
    Edel M Hyland
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, USA
    J Bacteriol 196:3002-11. 2014
    ..This study therefore successfully utilized plasmid segregation to dissect the molecular interactions between genotype, phenotype, and fitness. ..
  74. doi Identification and characterization of single-stranded DNA-binding protein from the facultative psychrophilic bacteria Pseudoalteromonas haloplanktis
    Marcin Olszewski
    Department of Microbiology, Chemical Faculty, Gdansk University of Technology, ul Narutowicza 11 12, 80 233 Gdansk, Poland
    Microbiol Res 169:139-47. 2014
    ..When analyzed by differential scanning calorimetry (DSC), the melting temperature (Tm) was determined as 63 °C, which is only a few degrees lower than for EcoSSB...
  75. pmc The integron integrase efficiently prevents the melting effect of Escherichia coli single-stranded DNA-binding protein on folded attC sites
    Celine Loot
    Institut Pasteur, Unité Plasticité du Génome Bactérien, Paris, France
    J Bacteriol 196:762-71. 2014
    ..We also tested the RecA host factor and excluded any role of this protein in integron recombination. ..
  76. pmc Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates
    Harshad Ghodke
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
    Proc Natl Acad Sci U S A 111:E1862-71. 2014
    ..This study proposes that UV-DDB recognizes lesions via multiple kinetic intermediates, through a conformational proofreading mechanism. ..
  77. ncbi Adsorption of modified halloysite nanotubes in vitro and the protective effect in rats exposed to zearalenone
    Yuanyuan Zhang
    a Institute of Animal Nutrition, Northeast Agricultural University, Harbin, P R China
    Arch Anim Nutr 68:320-35. 2014
    ..to investigate the sorption properties in vitro and the application feasibility of modified halloysite nanotubes (HNT) in reducing the toxic effect of ZEN in rats in vivo...
  78. pmc Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice
    Yoshinori Tanaka
    Acta Neuropathol Commun 2:78. 2014
    ..TAR DNA binding protein 43 (TDP-43) aggregates in the cytoplasm of neurons were also observed in aged PGRN-deficient mice...
  79. pmc The cytotoxic role of RREB1, ZIP3 zinc transporter, and zinc in human pancreatic adenocarcinoma
    Renty B Franklin
    Department of Oncology and Diagnostic Sciences University of Maryland Dental School Baltimore, MD USA The University of Maryland Greenebaum Cancer Center Baltimore, MD USA
    Cancer Biol Ther 15:1431-7. 2014
    ..Concurrent with the decrease in zinc, RREB1 transcription factor and ZIP3 zinc uptake transporter are downregulated...
  80. ncbi Nicotinic acetylcholine receptors on NT2 precursor cells and hNT (NT2-N) neurons
    Mary B Newman
    Center for Aging and Brain Repair, University of South Florida, Tampa, FL 33612, USA
    Brain Res Dev Brain Res 139:73-86. 2002
    ..nAChR) to further characterize a human, postmitotic, transplantable, with a neuronal phenotype, cell line called hNT (also called NT2-N)...
  81. ncbi A transgenic mouse model for T-cell ignorance of a glial autoantigen
    Julie Cabarrocas
    INSERM U563, Purpan University Hospital, Place Dr Baylac, Toulouse 31000, France
    J Autoimmun 22:179-89. 2004
    The fate of autoreactive CD4+T cells was investigated in HNT-TCR x GFAP-HA double transgenic mice, in which the majority of CD4+T cells is specific for a neo-selfantigen expressed under a glial cell-specific promoter...
  82. ncbi A telomere-binding protein (TRF2/MTBP) from mouse nuclear matrix with motives of an intermediate filament-type rod domain
    Alexey P Voronin
    Institute of Cytology, Russian Academy of Sciences, St Petersburg, Russia
    J Anti Aging Med 6:205-18. 2003
    ..These observations suggest that MTBP/TRF2 is a good candidate for the attachment of telomeres to the nuclear envelope in somatic cells...
  83. ncbi Source-sink dynamics and proteomic reprogramming under elevated night temperature and their impact on rice yield and grain quality
    Wanju Shi
    College of Agronomy, Hunan Agricultural University, Changsha, Hunan, 410128, China
    New Phytol 197:825-37. 2013
    ..A systematic analysis of HNT response at the physiological and molecular levels was performed under field conditions...
  84. ncbi The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer
    Nishit K Mukhopadhyay
    Department of Urology Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Mol Endocrinol 21:2056-70. 2007
    ..Collectively, our data for the first time identify RREB-1 as a repressor of AR and further implicate the Ras/MAPK kinase pathway as a likely antagonist of the inhibitory effects of RREB-1 on androgenic signaling...
  85. doi Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma
    Eva Bentmann
    Adolf Butenandt Institute, Department of Biochemistry, Ludwig Maximilians University, Munich, Germany
    FEBS J 280:4348-70. 2013
    ..Recently, some of these SG marker proteins were found to label pathological TAR DNA binding protein of 43 kDa (TDP-43)- or fused in sarcoma (FUS)-positive cytoplasmic inclusions in patients with amyotrophic ..
  86. ncbi The transcription factor Nurr1 in human NT2 cells and hNT neurons
    Iwona E Misiuta
    Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA
    Brain Res Dev Brain Res 145:107-15. 2003
    Human, neuronally committed hNT or NT2-N cells, originally derived from the Ntera2/D1 (NT2) clone after exposure to retinoic acid (RA), represent a potentially important source of cells to treat neurodegenerative diseases...
  87. pmc Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1
    S Riva
    EMBO J 5:2267-73. 1986
    Antibodies induced against mammalian single-stranded DNA binding protein (ssDBP) UP I were shown to be cross-reactive with most of the basic hnRNP core proteins, the main constituents of 40S hnRNP particles...
  88. ncbi Characterization of the Escherichia coli SSB-113 mutant single-stranded DNA-binding protein. Cloning of the gene, DNA and protein sequence analysis, high pressure liquid chromatography peptide mapping, and DNA-binding studies
    J W Chase
    J Biol Chem 259:805-14. 1984
    The ssb-113 (formerly lexC113) gene encoding a mutant single-stranded DNA binding protein (SSB) has been cloned into plasmid pSC101 resulting in 5- to 10-fold more mutant protein than strains carrying only one (chromosomal) copy of the ..
  89. pmc Herpes simplex virus type 1 single strand DNA binding protein and helicase/primase complex disable cellular ATR signaling
    Kareem N Mohni
    Department of Molecular, Microbial and Structural Biology and the Molecular Biology and Biochemistry Graduate Program, University of Connecticut Health Center, Farmington, Connecticut, United States of America
    PLoS Pathog 9:e1003652. 2013
    ..Here we report that the HSV-1 single stranded DNA binding protein (ICP8), and the helicase/primase complex (UL8/UL5/UL52) form a nuclear complex in transfected cells that is ..
  90. pmc Transcriptional stimulation by the DNA binding protein Hap46/BAG-1M involves hsp70/hsc70 molecular chaperones
    Yilmaz Niyaz
    Molekulare Evolution und Genomik, Im Neuenheimer Feld 230, and Biochemie Zentrum Heidelberg, D 69120 Heidelberg, Germany
    Nucleic Acids Res 31:2209-16. 2003
    ..of human origin, also called BAG-1M (Bcl-2-associated athanogene 1), has been characterized previously as a DNA binding protein, which is able to stimulate transcription...
  91. ncbi Complete inhibition of Streptococcus pneumoniae RecA protein-catalyzed ATP hydrolysis by single-stranded DNA-binding protein (SSB protein): implications for the mechanism of SSB protein-stimulated DNA strand exchange
    Scott E Steffen
    Department of Biochemistry, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 277:14493-500. 2002
    ....
  92. pmc The single-stranded DNA-binding protein WHIRLY1 represses WRKY53 expression and delays leaf senescence in a developmental stage-dependent manner in Arabidopsis
    Ying Miao
    Center for Molecular Cell and Systems Biology, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350003, China
    Plant Physiol 163:746-56. 2013
    ..These results suggest that WHY1 was an upstream regulator of WRKY53 during leaf senescence. ..
  93. doi Loss of TDP-43 causes age-dependent progressive motor neuron degeneration
    Yohei Iguchi
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Brain 136:1371-82. 2013
    ....
  94. doi A RAD52-like single-stranded DNA binding protein affects mitochondrial DNA repair by recombination
    Sabina Janicka
    Institut de Biologie Moléculaire des Plantes du Centre National de la Recherche Scientifique, Universite de Strasbourg, 12 rue du Général Zimmer, 67084 Strasbourg Cedex, France
    Plant J 72:423-35. 2012
    ..These observations identify ODB1 as a further component of homologous recombination-dependent DNA repair in plant mitochondria...
  95. doi RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum
    Matthew Thomas
    Department of Physiology, Anatomy and Genetics University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, UK
    Brain 136:1345-60. 2013
    ..TAR DNA binding protein and fused in sarcoma (FUS) are both RNA processing proteins whose dysfunction impacts on global cellular ..
  96. ncbi The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication
    M K Kenny
    Graduate Program in Molecular Biology, Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 265:7693-700. 1990
    Human single-stranded DNA binding protein (human SSB) is a multisubunit protein containing polypeptides of 70, 34, and 11 kDa that is required for SV40 DNA replication in vitro...
  97. ncbi A highly thermostable, homodimeric single-stranded DNA-binding protein from Deinococcus radiopugnans
    Paweł Filipkowski
    Department of Microbiology, Gdansk University of Technology, ul Narutowicza 11 12, 80 952 Gdansk, Poland
    Extremophiles 10:607-14. 2006
    ..DrpSSB is the most thermostable SSB-like protein identified to date, offering an attractive alternative for TaqSSB and TthSSB in their applications for molecular biology methods and analytical purposes...
  98. pmc Night temperature and source-sink effects on overall growth, cell number and cell size in bell pepper ovaries
    Rebecca L Darnell
    Horticultural Sciences Department, University of Florida, Gainesville, FL 32611, USA
    Ann Bot 110:987-94. 2012
    ..The present research examined the interactive effects of night temperature and source-sink ratio on ovary size, cell number and cell size at anthesis in bell pepper flowers...
  99. ncbi Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity
    T A Azam
    Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    J Biol Chem 274:33105-13. 1999
    ....
  100. pmc Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis
    D L Galson
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Mol Cell Biol 13:2929-41. 1993
    ..This region has not yet been found to be associated with a human malignancy...
  101. pmc Two modes of interaction of the single-stranded DNA-binding protein of bacteriophage T7 with the DNA polymerase-thioredoxin complex
    Sharmistha Ghosh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:18103-12. 2010
    ..Loop B appears to play an important role in communication with the helicase and gp2.5, whereas loop A plays a stabilizing role in these interactions...

Research Grants172 found, 100 shown here

  1. ALS therapies and genomics for mutant TDP-43 and TLS/FUS
    Don Cleveland; Fiscal Year: 2009
    ..New, very high through put DNA/RNA sequencing methods will be used to identify genes whose expression is altered by the mutations, thereby identifying new targets and approaches for devising a successful therapy for ALS. ..
  2. ALS therapies and genomics for mutant TDP-43 and TLS/FUS
    Don W Cleveland; Fiscal Year: 2010
    ..New, very high through put DNA/RNA sequencing methods will be used to identify genes whose expression is altered by the mutations, thereby identifying new targets and approaches for devising a successful therapy for ALS. ..
  3. Gamma Globin Induction: Molecular and Cell-Based Strategies
    BETTY SUE PACE; Fiscal Year: 2010
    ..In a parallel effort, high throughput drug screens will be conducted to discover potent chemical inducers of fetal hemoglobin to improve our chances of success. ..
  4. GENETICS OF DELAYED PUBERTY
    Lawrence C Layman; Fiscal Year: 2010
    ..Recently, we identified mutations in the chromodomain helicase DNA binding protein-7 (CHD7) and nasal embryonic LHRH factor (NELF) genes in sporadic IHH/KS patients...
  5. GENETICS OF DELAYED PUBERTY
    Lawrence C Layman; Fiscal Year: 2011
    ..Recently, we identified mutations in the chromodomain helicase DNA binding protein-7 (CHD7) and nasal embryonic LHRH factor (NELF) genes in sporadic IHH/KS patients...
  6. GENETICS OF DELAYED PUBERTY
    Lawrence C Layman; Fiscal Year: 2013
    ..Recently, we identified mutations in the chromodomain helicase DNA binding protein-7 (CHD7) and nasal embryonic LHRH factor (NELF) genes in sporadic IHH/KS patients...
  7. Regulation of EBV Latency by EBNA1
    Paul M Lieberman; Fiscal Year: 2013
    ..More detailed understanding of EBNA1 is further justified by its potential value as a target for therapeutic intervention in diseases and cancers associated with EBV latent infection. ..
  8. Astrocyte Development and Reactive Gliosis
    Teri L Belecky Adams; Fiscal Year: 2010
    ....
  9. Epithelial differentiation in cornea
    Bogi Andersen; Fiscal Year: 2009
    ....
  10. Transcriptional regulation of enteroendocrine cell differentiation by NeuroD
    Andrew B Leiter; Fiscal Year: 2010
    ..Aim 1 will examine how NeuroD associates with Sp1, RREB1, and LSD1 at one its known targets, the secretin gene to form a multiprotein coactivator complex...
  11. Epigenetic mechanisms of TDP43-mediated neurodegeneration
    Amit Berson; Fiscal Year: 2013
    ..These devastating diseases are characterized by the abnormal cytoplasmic accumulation of TDP-43, an RNA and DNA binding protein. Mutations in the TDP-43 coding gene (TARDBP) are found in rare forms of FTD and ALS, providing additional ..
  12. Hepatitis B virus replication and DDB1
    Betty L Slagle; Fiscal Year: 2013
    ..also involved in carcinogenesis We and others have shown that the interaction of HBx with cellular damaged DNA binding protein (DDB1) is critical for HBV replication...
  13. TDP-43 acetylation as a pathogenic modification in ALS &related proteinopathies
    TODD JONATHAN COHEN; Fiscal Year: 2012
    ..TAR DNA-binding protein of 43kD (TDP-43) is a nuclear RNA and DNA binding protein that becomes abnormally aggregated in the brain and spinal cord of most ALS patients as well as a subset of ..
  14. MECHANISMS NEUROTROPHIN SIGNALING THROUGH P75 RECEPTOR
    Bruce D Carter; Fiscal Year: 2011
    ..The cleavage of p75 releases its intracellular domain (ICD) along with NRIF, a DNA binding protein, thereby facilitating NRIF translocation to the nucleus, which leads to apoptosis...
  15. FUS/TLS GAIN AND LOSS OF FUNCTION IN ALS: ANIMAL AND CELLULAR MODELS OF DISEASE
    NEIL ALAN SHNEIDER; Fiscal Year: 2011
    ..This effort will provide new tools to develop and test much-needed therapies for familial and sporadic ALS. ..
  16. DETERMINATION OF NEURONAL FATES IN VISUAL CORTEX
    Susan K McConnell; Fiscal Year: 2013
    ..The goals of our research are to identify the genes that regulate neurogenesis in the visual cortex and to understand how they affect the formation of cortical circuitry. ..
  17. TDP-43 acetylation as a pathogenic modification in ALS &related proteinopathies
    TODD JONATHAN COHEN; Fiscal Year: 2013
    ..TAR DNA-binding protein of 43kD (TDP-43) is a nuclear RNA and DNA binding protein that becomes abnormally aggregated in the brain and spinal cord of most ALS patients as well as a subset of ..
  18. Peri-arteriolar Myofibroblast Differentiation in the Pathobiology of IPAH
    ARTHUR ROGER STRAUCH; Fiscal Year: 2011
    ..The proposed research may lead to the design of new treatment strategies for this devastating lung vascular disease that has no cure and only treatable by performing lung transplantation surgery. (End of Abstract) ..
  19. Amphetamine-Induced Transcriptional Plasticity in Striatal GABAergic Interneurons
    ANNE ELIZABETH WEST; Fiscal Year: 2013
    ..However we discovered that AMPH administration drives rapid and robust phosphorylation of the methyl-DNA binding protein MeCP2 at Ser421 (pMeCP2) in the NAc, and that this AMPH-induced phosphorylation occurs selectively in FSIs...
  20. Novel immunotherapeutics for the management of otitis media due to H. influenzae
    Steven D Goodman; Fiscal Year: 2013
    ..expand upon studies that will explore the observed synergy between antibodies directed against IHF (a DNA binding protein) and other enzymes, antibodies and/or antibiotics, then apply our advanced understanding to the design and ..
  21. Regulation of Cocaine Reward and Reinforcement by MeCP2
    ANNE ELIZABETH WEST; Fiscal Year: 2013
    ..We have shown that genetically manipulating the expression of the methyl-DNA binding protein MeCP2 in specific regions of the adult striatum modulates the ability of cocaine and the related ..
  22. Transcriptional regulation of enteroendocrine cell differentiation by NeuroD
    Andrew B Leiter; Fiscal Year: 2013
    ..Aim 1 will examine how NeuroD associates with Sp1, RREB1, and LSD1 at one its known targets, the secretin gene to form a multiprotein coactivator complex...
  23. FUS/TLS GAIN AND LOSS OF FUNCTION IN ALS: ANIMAL AND CELLULAR MODELS OF DISEASE
    NEIL ALAN SHNEIDER; Fiscal Year: 2013
    ....
  24. REGULATION AND FUNCTION OF THE TAL1/SCL GENE
    Stephen J Brandt; Fiscal Year: 2010
    ....
  25. Molecular library screen for suppressors of FUS proteinopathy
    Frank P Shewmaker; Fiscal Year: 2012
    ..Our system offers a fast and inexpensive screening mechanism to find drug leads that may eventually be developed into therapeutics capable of reducing the neurodegeneration in ALS, FTLD and other disorders. ..
  26. Molecular library screen for suppressors of FUS proteinopathy
    Frank P Shewmaker; Fiscal Year: 2013
    ..Our system offers a fast and inexpensive screening mechanism to find drug leads that may eventually be developed into therapeutics capable of reducing the neurodegeneration in ALS, FTLD and other disorders. ..
  27. Genetic modifiers of motor neuron degeneration
    RANDAL SCOT TIBBETTS; Fiscal Year: 2010
    ..We believe that the fruit fly model of ALS to be explored in this proposal will provide important clues regarding ALS pathogenesis that may lead to new therapies. ..
  28. GENETIC ASPECTS OF DNA METHYLATION
    Eric U Selker; Fiscal Year: 2011
    ..In humans, loss of a DNA methyltransferase (MTase) causes ICF syndrome, loss of the methyl- DNA binding protein MeCP2 causes Rett syndrome and abnormal methylation is associatedwith cancer. ...
  29. Elucidating the Mechanisms Underlying Mutant TDP43-induced Neurodegeneration
    Sami Barmada; Fiscal Year: 2013
    ..of ALS and the most prevalent type of FTD share a common pathology marked by the deposition of the TAR DNA binding protein of 43 kDa (TDP-43)...
  30. Elucidating the Mechanisms Underlying Mutant TDP43-induced Neurodegeneration
    Sami Barmada; Fiscal Year: 2013
    ..of ALS and the most prevalent type of FTD share a common pathology marked by the deposition of the TAR DNA binding protein of 43 kDa (TDP-43)...
  31. Biology of the Myb-MuvB Oncoprotein-Tumor Suppressor Protein Complex
    JOSEPH STEVEN LIPSICK; Fiscal Year: 2010
    ....
  32. Multilevel Targeted Therapeutics Using Surface Functionalized Nanoparticles encap
    JILL STEINBACH; Fiscal Year: 2012
    ..2 (a DNA binding protein affecting virus replication) and nectin-1 (a host cell receptor protein integral to initial viral binding ..
  33. DNA-Binding Protein Discovery by the Combinatorial Method REPSA
    Michael van Dyke; Fiscal Year: 2013
    ..We expect our research to ultimately catalyze numerous studies by us and other laboratories leading to a better understanding of E. coli biology at a molecular level and provide a framework for similar studies in other organisms. ..
  34. Development of Novel Agents Targeting Genome Stability and Maintenance for Treati
    John J Turchi; Fiscal Year: 2013
    ..we will pursue the development and analysis of small molecule inhibitors (SMIs) of the human single-strand DNA binding protein replication protein A (RPA)...
  35. Effect of ALS-causing Mutations on Binding of TDP43 and FUS to RNA in iMNs
    HELAINA JESSICA SKOP; Fiscal Year: 2013
    ..Mutations in two RNA binding proteins, TAR DNA binding protein 43 (TDP43) and Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS), cause some forms of familial ..
  36. TOX, a Novel Regulator of Thymocyte Selection
    JONATHAN G KAYE; Fiscal Year: 2010
    ....
  37. Mechanism of the Transcriptional Response to Transition Metals
    MICHAEL THOMAS MARR; Fiscal Year: 2010
    ..MTF-1 is a sequence specific DNA binding protein that perceives the metal status of a cell and activates genes accordingly...
  38. TOX, a Novel Regulator of Thymocyte Selection
    JONATHAN G KAYE; Fiscal Year: 2013
    ....
  39. Mechanism of the Transcriptional Response to Transition Metals
    MICHAEL THOMAS MARR; Fiscal Year: 2010
    ..MTF-1 is a sequence specific DNA binding protein that perceives the metal status of a cell and activates genes accordingly...
  40. NMR Studies of Protein Side-Chain Dynamics
    MARK A RANCE; Fiscal Year: 2010
    ....
  41. Progranulin, TDP-43 and Cell Death
    Leonard Petrucelli; Fiscal Year: 2013
    ..Our hypothesis is that loss of functional PGRN leads to loss of functional TDP-43, which leads to cell death. ..
  42. Inhibition of Stat3 and inflammatory cytokine production
    Lionel B Ivashkiv; Fiscal Year: 2010
    ..Notch and TLR signaling was integrated at the level of the DNA binding protein RBP-J...
  43. CYTOKINE REGULATION OF CIITA AND CLASS II MHC IN GLIA
    ETTY BENVENISTE; Fiscal Year: 1999
    ..that regulation of class II MHC genes occurs primarily at the transcriptional level, dependent on a non-DNA binding protein, Class II transactivator (CIITA)...
  44. MECHANISMS NEUROTROPHIN SIGNALING THROUGH P75 RECEPTOR
    Bruce D Carter; Fiscal Year: 2013
    ..The cleavage of p75 releases its intracellular domain (ICD) along with NRIF, a DNA binding protein, thereby facilitating NRIF translocation to the nucleus, which leads to apoptosis...
  45. Mechanisms of HbF Activation by Non-deletional HPFH
    Kenneth R Peterson; Fiscal Year: 2013
    ....
  46. Pin1-dependent telomere regulation in aging and Alzheimer's disease
    Tae Ho Lee; Fiscal Year: 2013
    ..These studies should provide novel insight into telomere maintenance during aging and AD, and might have novel implications for developing new therapies. ..
  47. NEUROGENESIS AND MIGRATION IN DEVELOPING CEREBRAL CORTEX
    Susan K McConnell; Fiscal Year: 2013
    ..abstract_text> ..
  48. Molecular analysis of CHD4
    Tatiana G Kutateladze; Fiscal Year: 2012
    ..These experiments will also provide important insights into CHD4/NuRD-dependent signaling pathways that may constitute new targets for therapeutic manipulation. ..
  49. Development of retinal ganglion cell types
    David A Feldheim; Fiscal Year: 2013
    ....
  50. Intracellular Defenses Against Foreign DNA: Insights From Poxvirus-Infected Cells
    Matthew S Wiebe; Fiscal Year: 2013
    ..poxviral B1 kinase is essential for viral DNA replication because it is needed to inactivate the cellular DNA binding protein BAF (barrier to autointegration factor)...
  51. Selective over expression of TDP-43 in APP/PS1 mice alters APP processing
    MICHAEL ANDRE GITCHO; Fiscal Year: 2013
    ..This in vivo model potentially could lead to the development of new therapeutics targeted at slowing the progression. ..
  52. Borrelia burdorferi Ebfc regulon
    Brian Stevenson; Fiscal Year: 2013
    ..Thus, our continued studies will focus efforts toward production of improved preventative and curative therapies for not only Lyme disease, but also many other significant human infectious diseases. ..
  53. Evolution of Telomere End Protection
    ROBERT ANTHONY HOM; Fiscal Year: 2013
    ..Aim 2 will track how the DNA binding protein Cdc13, and its subunits Stn1 and Ten1, has evolved in their recognition of telomeric DNA...
  54. The mechanism linking traumatic brain injury to amyotrophic lateral sclerosis
    TERESA EVANS; Fiscal Year: 2013
    ..Interestingly, another protein, transactivation response or TAR DNA Binding Protein 43 (TDP-43), forms aggregates in both ALS and TBI which suggests that protein aggregation could be a ..
  55. Elucidating the Chemistry and Targets of Cross-linking by Endogenous DNA Damage
    Sarah C Shuck; Fiscal Year: 2013
    ..This investigation represents the first study to elucidate the interaction of OPdA with DNA-binding proteins. ..
  56. INTEGRATION SPECIFICITY OF THE TY3 RETROTRANSPOSON
    Suzanne Sandmeyer; Fiscal Year: 1999
    ..TFIIIC suppressors identified in the Sentenac lab will be analyzed for affects on Ty3 transposition. As residues in Ty3 are identified which are critical to targeting, suppressor screens for interacting host factors will be performed. ..
  57. Development of a novel whole genome amplification method that mimics nature
    Huimin Kong; Fiscal Year: 2009
    ..utilizes multiple replication proteins including a primase/helicase, a DNA polymerase, a single-stranded DNA binding protein, and several other accessory proteins to achieve rapid and sensitive whole genome amplification...
  58. Elucidation of Novel Post-Translational Mechanisms That Regulate Notch Activity
    RYAN SCOTT UNDERWOOD; Fiscal Year: 2013
    ..By characterizing these two mechanisms, this proposal aims to increase the understanding of how the critical Notch pathway is regulated and potentially provide novel therapeutic strategies for diseases such as T-ALL. ..
  59. The Role of TDP-43 Phosphorylation in Protein Function and Neurodegeneration
    YOUHNA AYALA; Fiscal Year: 2013
    ..applicant): The overall goal of this project is to identify factors that regulate the function of the TAR DNA binding protein (TDP-43)...
  60. Development of a novel whole genome amplification method that mimics nature
    Huimin Kong; Fiscal Year: 2007
    ..utilizes multiple replication proteins including a primase/helicase, a DNA polymerase, a single- stranded DNA binding protein, and several other accessory proteins...
  61. Biochemical and Genetic Analysis of Notch Signaling
    Raphael Kopan; Fiscal Year: 2013
    ....
  62. REGULATION OF DNA REPLICATION
    CHARLES MCHENRY; Fiscal Year: 1999
    ..III holenzyme with the even-protein primosome-primary complex on a template coated with single-stranded DNA binding protein. These coordinate reactions include; (i) signalling between the primase as it synthesizes a primer for a ..
  63. REGULATION OF DNA REPLICATION
    CHARLES MCHENRY; Fiscal Year: 2000
    ..III holenzyme with the even-protein primosome-primary complex on a template coated with single-stranded DNA binding protein. These coordinate reactions include; (i) signalling between the primase as it synthesizes a primer for a ..
  64. ACTIVATION OF RNA POLYMERASE BY SSDNA BINDING PROTEIN
    LUCIA ROTHMAN DENES; Fiscal Year: 1999
    DESCRIPTION: The bacteriophage N4 single-stranded DNA binding protein (N4SSB) is essential for phage replication, recombination and, unexpectedly, late transcription...
  65. Thermodynamics and kinetics of DNA binding protein probed by DNA overstretching
    Andreas Hanke; Fiscal Year: 2010
    ..Specifically, Bacteriophage T7 gene 2.5 protein (gp2.5) is a single-stranded DNA binding protein that has essential roles in DNA replication and recombination in phage-infected cells...
  66. Thermodynamics and kinetics of DNA binding protein probed by DNA overstretching
    Andreas Hanke; Fiscal Year: 2009
    ..Specifically, Bacteriophage T7 gene 2.5 protein (gp2.5) is a single-stranded DNA binding protein that has essential roles in DNA replication and recombination in phage-infected cells...
  67. HMGB1 and neutrophil efferocytosis.
    Edward Abraham; Fiscal Year: 2010
    ....
  68. HMGB1 and neutrophil efferocytosis.
    Edward Abraham; Fiscal Year: 2009
    ....
  69. RECOGNITION OF METHYLATED DNA BY MAMMALIAN PROTEINS
    Melanie Ehrlich; Fiscal Year: 1993
    ..We will continue trying to clone MDBP-1 cDNA. Lastly, we will determine the effect on gene expression of changing a methylation-independent site in the HBV enhancer to a methylation- dependent site...
  70. Protein Dynamics in Homeodomain/DNA Complexes
    Mark Rance; Fiscal Year: 2003
    ..abstract_text> ..
  71. Protein Dynamics in Homeodomain/DNA Complexes
    Mark Rance; Fiscal Year: 2007
    ..abstract_text> ..
  72. Protein Dynamics in Homeodomain/DNA Complexes
    Mark Rance; Fiscal Year: 2004
    ..abstract_text> ..
  73. Protein Dynamics in Homeodomain/DNA Complexes
    Mark Rance; Fiscal Year: 2005
    ..abstract_text> ..
  74. ORGANIZATION AND EXPRESSION OF DNA TUMOR VIRUS GENOMES
    Bayar Thimmapaya; Fiscal Year: 1993
    ..promoter (E2-early) which transcribes a region of the viral genome that encodes a 72 kD single stranded DNA binding protein, an 80 kD precursor terminal protein and the 140 kD DNA polymerase all of which are vital for virus growth...
  75. FUNCTIONS OF AN EIA-ASSOCIATED CELLULAR PROTEIN
    Bayar Thimmapaya; Fiscal Year: 2000
    ..promoter (E2-early) which transcribes a region of the viral genome that encodes a 72 kD single stranded DNA binding protein, an 80 kD precursor terminal protein and the 140 kD DNA polymerase all of which are vital for virus growth...
  76. FUNCTIONS OF AN EIA-ASSOCIATED CELLULAR PROTEIN
    Bayar Thimmapaya; Fiscal Year: 2002
    ..promoter (E2-early) which transcribes a region of the viral genome that encodes a 72 kD single stranded DNA binding protein, an 80 kD precursor terminal protein and the 140 kD DNA polymerase all of which are vital for virus growth...
  77. FUNCTIONS OF AN EIA-ASSOCIATED CELLULAR PROTEIN
    Bayar Thimmapaya; Fiscal Year: 2001
    ..promoter (E2-early) which transcribes a region of the viral genome that encodes a 72 kD single stranded DNA binding protein, an 80 kD precursor terminal protein and the 140 kD DNA polymerase all of which are vital for virus growth...
  78. FUNCTIONS OF AN EIA-ASSOCIATED CELLULAR PROTEIN
    Bayar Thimmapaya; Fiscal Year: 2001
    ..promoter (E2-early) which transcribes a region of the viral genome that encodes a 72 kD single stranded DNA binding protein, an 80 kD precursor terminal protein and the 140 kD DNA polymerase all of which are vital for virus growth...
  79. FUNCTIONS OF AN EIA-ASSOCIATED CELLULAR PROTEIN
    Bayar Thimmapaya; Fiscal Year: 1999
    ..promoter (E2-early) which transcribes a region of the viral genome that encodes a 72 kD single stranded DNA binding protein, an 80 kD precursor terminal protein and the 140 kD DNA polymerase all of which are vital for virus growth...
  80. MITOCHONDRIAL DNA POLYMERASE--MECHANISM AND STRUCTURE
    LAURIE KAGUNI; Fiscal Year: 1999
    ..To initiate the development of a transgenic fly model to examine the relationship between Pol gamma function, mitochondrial DNA replication fidelity, aging and disease. ..
  81. REGULATION OF GENE EXPRESSION IN PHAGOCYTIC CELLS
    DAVID SKALNIK; Fiscal Year: 1993
    ....