RRAD

Summary

Gene Symbol: RRAD
Description: Ras-related associated with diabetes
Alias: RAD, RAD1, REM3, GTP-binding protein RAD, RAS (RAD and GEM) like GTP binding 3, ras associated with diabetes
Species: human

Top Publications

  1. ncbi The structure and function of RAD6 and RAD18 DNA repair genes of Saccharomyces cerevisiae
    L Prakash
    Department of Biophysics, University of Rochester School of Medicine, NY 14642
    Genome 31:597-600. 1989
  2. pmc Evaluation of 99mtechnetium-radiopharmaceutical binding to blood elements using different trichloroacetic acid concentrations
    R S Freitas
    , , Rio de Janeiro, Brasil
    Yale J Biol Med 69:483-8. 1996
  3. pmc Specificities of the Saccharomyces cerevisiae rad6, rad18, and rad52 mutators exhibit different degrees of dependence on the REV3 gene product, a putative nonessential DNA polymerase
    H Roche
    Department of Microbiology, University of Manitoba, Winnipeg, Canada
    Genetics 140:443-56. 1995
  4. pmc Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function
    G L Kiser
    Molecular and Cellular Biology Department, University of Arizona, Tucson 85721, USA
    Mol Biol Cell 7:703-18. 1996
  5. ncbi Yeast RAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins
    M Bankmann
    Department of Biophysics, University of Rochester School of Medicine, New York 14642 8408
    Nature 355:555-8. 1992
  6. pmc Effects of mutations of RAD50, RAD51, RAD52, and related genes on illegitimate recombination in Saccharomyces cerevisiae
    Y Tsukamoto
    Department of Molecular Biology, Univesity of Tokyo, Japan
    Genetics 142:383-91. 1996
  7. pmc Nucleotide-excision repair of DNA in cell-free extracts of the yeast Saccharomyces cerevisiae
    Z Wang
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235
    Proc Natl Acad Sci U S A 90:4907-11. 1993
  8. pmc Expression of the E.coli ada gene in S.cerevisiae provides cellular resistance to N-methyl-N'-nitro-N-nitrosoguanidine in rad6 but not in rad52 mutants
    J Brozmanova
    Department of Molecular Genetics, Cancer Research Institute, Slovak Academy of Sciences, Bratislava
    Nucleic Acids Res 22:5717-22. 1994
  9. pmc Role of reciprocal exchange, one-ended invasion crossover and single-strand annealing on inverted and direct repeat recombination in yeast: different requirements for the RAD1, RAD10, and RAD52 genes
    F Prado
    , , Universidad de Sevilla, Spain
    Genetics 139:109-23. 1995
  10. ncbi Arthropod touch reception: spider hair sensilla as rapid touch detectors
    J T Albert
    University of Vienna, Biocenter, Institute of Zoology, Wien, Austria
    J Comp Physiol A 187:303-12. 2001

Research Grants

  1. DNA REPAIR IN A HORMONE RESPONSIVE GENE
    Michael J Smerdon; Fiscal Year: 2010
  2. DNA REPAIR IN A HORMONE RESPONSIVE GENE
    Michael J Smerdon; Fiscal Year: 2011
  3. DNA REPAIR IN A HORMONE RESPONSIVE GENE
    Michael Smerdon; Fiscal Year: 1999
  4. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
  5. Brain Motion During Blunt Impact
    Albert King; Fiscal Year: 2007
  6. Repair of Oxidatively Damaged Guanines
    A LIEN L LU CHANG; Fiscal Year: 2010
  7. Programming Airway Epithelial Differentiation by Rad
    Reen Wu; Fiscal Year: 2007
  8. Repair of Oxidatively Damaged Guanines
    A LIEN L LU CHANG; Fiscal Year: 2010
  9. Lipid Carriers in Membrane Glycoproteins
    William Lennarz; Fiscal Year: 2006
  10. GENE EXPRESSION IN DIABETES BY SUBTRACTIVE CLONING
    C Kahn; Fiscal Year: 2000

Detail Information

Publications174 found, 100 shown here

  1. ncbi The structure and function of RAD6 and RAD18 DNA repair genes of Saccharomyces cerevisiae
    L Prakash
    Department of Biophysics, University of Rochester School of Medicine, NY 14642
    Genome 31:597-600. 1989
    ..Addition of the first four residues of the polyacidic tail restores sporulation to 50% the level observed in RAD+/RAD+ diploids...
  2. pmc Evaluation of 99mtechnetium-radiopharmaceutical binding to blood elements using different trichloroacetic acid concentrations
    R S Freitas
    , , Rio de Janeiro, Brasil
    Yale J Biol Med 69:483-8. 1996
    ..5 and 0.1 percent) and soluble (SF) and insoluble fractions (IF) were isolated. The percent radioactivity (percent rad) in IF-P depends on TCA concentration. It varied from 36.4 to 65.0 (99mTc-PHY), from 17.9 to 32...
  3. pmc Specificities of the Saccharomyces cerevisiae rad6, rad18, and rad52 mutators exhibit different degrees of dependence on the REV3 gene product, a putative nonessential DNA polymerase
    H Roche
    Department of Microbiology, University of Manitoba, Winnipeg, Canada
    Genetics 140:443-56. 1995
    ..to encode a DNA polymerase that specializes in translesion synthesis, we determined the REV3 dependence of the rad mutator specificities...
  4. pmc Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function
    G L Kiser
    Molecular and Cellular Biology Department, University of Arizona, Tucson 85721, USA
    Mol Biol Cell 7:703-18. 1996
    ..The conclusion that the yeast MEC1 gene is a key regulator also has implications for the role of a putative human homologue, the ATM gene...
  5. ncbi Yeast RAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins
    M Bankmann
    Department of Biophysics, University of Rochester School of Medicine, New York 14642 8408
    Nature 355:555-8. 1992
    ..Mutations in any one of five yeast genes, RAD1, RAD2, RAD3, RAD4, and RAD10, cause a total defect in incision and an extreme sensitivity to ultraviolet light...
  6. pmc Effects of mutations of RAD50, RAD51, RAD52, and related genes on illegitimate recombination in Saccharomyces cerevisiae
    Y Tsukamoto
    Department of Molecular Biology, Univesity of Tokyo, Japan
    Genetics 142:383-91. 1996
    ..Study on the effect of several rad mutations showed that the recombination rate was reduced by 30-, 10-, 10-, and 10-fold in the rad52, rad50, mre11, ..
  7. pmc Nucleotide-excision repair of DNA in cell-free extracts of the yeast Saccharomyces cerevisiae
    Z Wang
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235
    Proc Natl Acad Sci U S A 90:4907-11. 1993
    ..Repair synthesis in vitro was defective in extracts of rad1, rad2, and rad10 mutant cells, all of which have mutations in genes whose products are known to be required for NER ..
  8. pmc Expression of the E.coli ada gene in S.cerevisiae provides cellular resistance to N-methyl-N'-nitro-N-nitrosoguanidine in rad6 but not in rad52 mutants
    J Brozmanova
    Department of Molecular Genetics, Cancer Research Institute, Slovak Academy of Sciences, Bratislava
    Nucleic Acids Res 22:5717-22. 1994
    ..was introduced into the wild-type yeast strains, YNN-27 and FF-18733, and the repair deficient mutants LN-1 (rad1-1), VV-5 (rad6-1), C5-6 (rad52-1) and FF-18742 (rad52::URA3)...
  9. pmc Role of reciprocal exchange, one-ended invasion crossover and single-strand annealing on inverted and direct repeat recombination in yeast: different requirements for the RAD1, RAD10, and RAD52 genes
    F Prado
    , , Universidad de Sevilla, Spain
    Genetics 139:109-23. 1995
    ..Those deletion events initiated through a DSB in the unique intervening sequence require the Rad1/Rad10 endonuclease only if the break is distantly located from the flanking DNA repeats...
  10. ncbi Arthropod touch reception: spider hair sensilla as rapid touch detectors
    J T Albert
    University of Vienna, Biocenter, Institute of Zoology, Wien, Austria
    J Comp Physiol A 187:303-12. 2001
    ..The torsional restoring constant S changes non-linearly with deflection angle. It is of the order of 10(-8) Nm/rad, which is about 10,000 times larger than for trichobothria...
  11. pmc Human studies with synthetic peptide sporozoite vaccine (NANP)3-TT and immunization with irradiated sporozoites
    D A Herrington
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201
    Bull World Health Organ 68:33-7. 1990
    ..P. falciparum-infected mosquitos were irradiated with 20,000 rad (200 Gy)...
  12. pmc The role of DNA repair genes in recombination between repeated sequences in yeast
    B Liefshitz
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv, Israel
    Genetics 140:1199-211. 1995
    ..Among seven genes involved in excision repair tested, only RAD1 and RAD10 played a role in the types of recombination studied...
  13. pmc Co-correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro
    M Biggerstaff
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK
    EMBO J 12:3685-92. 1993
    ..The data suggest that ERCC1 is part of a functional protein complex with group 4 and XP-F correcting activities. The latter two may be equivalent to one another and analogous to S. cerevisiae RAD1.
  14. ncbi Genetic evidence for different RAD52-dependent intrachromosomal recombination pathways in Saccharomyces cerevisiae
    A Aguilera
    , , Universidad de Sevilla, Spain
    Curr Genet 27:298-305. 1995
    ..However, they enhance the frequency of deletions between direct repeats 5-12-fold. These induced deletions are RAD1- and RAD52-dependent...
  15. ncbi Cisplatin DNA cross-links do not inhibit S-phase and cause only a G2/M arrest in Saccharomyces cerevisiae
    K F Grossmann
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Mutat Res 434:29-39. 1999
    ..mec1, mec3 and rad53) showed increased sensitivity to CDDP, as did controls with a defect in excision repair (rad1 and rad14) or a defect in recombination (rad51 and rad52)...
  16. ncbi Establishment and biological properties of mouse granulocytic leukemic cell line-L833
    X L Li
    Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing
    Sci Sin B 31:328-37. 1988
    ..It was also sensitive to ionizing radiation. D0 values of L833 and L883-A cells were 98.8 and 104.9 rad, respectively. The results were similar to that of L801...
  17. doi Immune responses of recombinant adenoviruses expressing immunodominant epitopes against Japanese encephalitis virus
    Peng Li
    Key Laboratory of Animal Disease Diagnosis and Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China
    Vaccine 26:5802-7. 2008
    ..Intramuscular immunization of mice with rAd-TEP generated greater titers of anti-JEV antibodies and JEV neutralizing activity than in animals with oral ..
  18. ncbi Analysis of spontaneous and double-strand break-induced recombination in rad mutants of S. pombe
    E A Fortunato
    Department of Biology, University of California San Diego, La Jolla 92093 0322, USA
    Mutat Res 364:14-60. 1996
    ..In S. cerevisiae, the DSB/gap repair pathway is RAD52 dependent, and the RAD1 and RAD10 genes are involved in the SSA pathway...
  19. ncbi Stability of YACs containing ribosomal or RCP/GCP locus DNA in wild-type S. cerevisiae and RAD mutant strains
    K Kohno
    Department of Molecular and Cellular Biology for Pharmaceutical Sciences, Kyoto Pharmaceutical University, Japan
    DNA Res 1:191-9. 1994
    ..5 rDNA tandem repeat units were transformed into hosts bearing lesions at the RAD1, RAD6, RAD51, or RAD52 loci...
  20. ncbi Analysis of gene- and strand-specific repair in the moderately UV-sensitive Saccharomyces cerevisiae rad23 mutant
    R A Verhage
    Laboratory of Molecular Genetics, Leiden Institute of Chemistry, Leiden University, The Netherlands
    Mutat Res 362:155-65. 1996
    ..The rad23 mutation does not suppress the high UV sensitivity of completely NER-deficient rad1 or rad14 strains...
  21. ncbi Sensitivity to cisplatin and platinum-containing compounds of Schizosaccharomyces pombe rad mutants
    P Perego
    Department of Experimental Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy
    Mol Pharmacol 54:213-9. 1998
    ..1-21.7-fold hypersensitive; only rad1 and -3 mutants, defective in checkpoints, and rad18, defective in repair, displayed a marked hypersensitivity...
  22. doi Prevalence and risk factors in postoperative pancreatitis after spine fusion in patients with cerebral palsy
    Battugs Borkhuu
    Department of Orthopedics, Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    J Pediatr Orthop 29:256-62. 2009
    ..The aim of this study was to assess the association between preoperative comorbidities and other parameters in the development of pancreatitis after spinal fusion surgery in a sample of children with CP...
  23. ncbi Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins
    M C Rosenhagen
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Chem 382:499-504. 2001
    Radicicol (RAD) and the benzoquinone ansamycin geldanamycin (GA) are potential anticancer drugs known to inhibit heat shock protein 90 (hsp90) and, therefore, the activation of proteins dependent on its function such as proto-oncogenic ..
  24. ncbi Cell therapy with a tissue-engineered kidney reduces the multiple-organ consequences of septic shock
    H David Humes
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109 0726, USA
    Crit Care Med 31:2421-8. 2003
    ..bioartificial kidney consisting of a conventional hemofiltration cartridge in series with a renal tubule assist device (RAD) containing 109 renal proximal tubule cells may be a new therapeutic approach to this clinical disorder.
  25. ncbi Comparison of ampholytes used for slab gel and capillary isoelectric focusing of recombinant tissue-type plasminogen activator glycoforms
    A B Chen
    Department of Quality Control Clinical Development, Genentech Inc, South San Francisco, CA 94080, USA
    J Chromatogr A 744:279-84. 1996
    Four commercial ampholytes: Ampholine and Pharmalyte (Pharmacia Biotech), Bio-Lyte (Bio-Rad) and Servalyt (Serva) were evaluated for their ability to resolve recombinant tissue-type plasminogen activator (rt-PA) glycoforms by isoelectric ..
  26. ncbi Triplet- vs. singlet-state imposed photochemistry. The role of substituent effects on the photo-Fries and photodissociation reaction of triphenylmethyl silanes
    Antonios K Zarkadis
    Department of Chemistry, University of Ioannina, 451 10 Ioannina, Greece
    Photochem Photobiol Sci 4:469-80. 2005
    ..of 1* is a one-quantum process and takes place via the carbonyl triplet excited state with high quantum yield (Phi(rad)= 0...
  27. ncbi Comparative thermal stabilities of recombinant adenoviruses and hexon protein
    Peter M Ihnat
    Biotechnology Development, Schering Plough Research Institute, Union, NJ 07081 3121, USA
    Biochim Biophys Acta 1726:138-51. 2005
    ..of the replication deficient and protein IX deleted recombinant adenovirus type 5 that contains the p53 transgene (rAd/p53) in phosphate buffered saline (vPBS) or 10% glycerol (TRIS/phosphate buffer)...
  28. ncbi Downregulation of Hus1 by antisense oligonucleotides enhances the sensitivity of human lung carcinoma cells to cisplatin
    Bernd Kinzel
    Department of Functional Genomics, Novartis Pharma AG, Basel, Switzerland
    Cancer 94:1808-14. 2002
    ..Hus1 has been shown to exist in a discrete complex with at least two Rad family members, Rad1 and Rad9...
  29. doi Phosphorylation and cytoplasmic localization of MAPK p38 during apoptosis signaling in bone marrow granulocytes of mice irradiated in vivo and the role of amifostine in reducing these effects
    Helena R C Segreto
    Department of Clinical and Experimental Oncology, Radiotherapy Division, Federal University of Sao Paulo, UNIFESP, Rua Pascal 778, Sao Paulo, SP, Brazil
    Acta Histochem 113:300-7. 2011
    ..Sixty-four C57BL mice were randomly assigned in two non-irradiated (Ami-/rad- and Ami+/rad-) and two irradiated (Ami-/rad+ and Ami+/rad+) groups. Animals received 400mg/kg of amifostine i.p...
  30. ncbi Function of pokeweed mitogen-stimulated human T cells following vaccination with pneumococcal polysaccharides
    C Heilmann
    Department of Medical Immunology, Rigshospitalet, Copenhagen, Denmark
    Acta Pathol Microbiol Immunol Scand C 95:207-12. 1987
    ..Irradiation (2300 rad) of T cells from day 0 increased the numbers of anti-PPS-SC in the cultures significantly (three times), whereas ..
  31. doi CD40 ligand expressed in adenovirus can improve the immunogenicity of the GP3 and GP5 of porcine reproductive and respiratory syndrome virus in swine
    Jun Cao
    Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
    Vaccine 28:7514-22. 2010
    ..The results showed that rAd-CD40L-GP35 (co-expressing CD40L and GP3-GP5) or rAd-GP35 (expressing GP3-GP5) plus rAd-CD40L (expressing CD40L) ..
  32. ncbi Dose schedule of recombinant murine thrombopoietin prior to myelosuppressive and myeloablative therapy in mice
    E G Stefanich
    Genentech Inc, South San Francisco, CA, USA
    Cancer Chemother Pharmacol 47:70-7. 2001
    ....
  33. ncbi Holliday junction cleavage by yeast Rad1 protein
    Y Habraken
    Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston 77555 1061
    Nature 371:531-4. 1994
    In Saccharomyces cerevisiae, of the many genes required for excision repair of ultraviolet-damaged DNA, only RAD1 and RAD10 also function in genetic recombination...
  34. doi Inhibition of porcine reproductive and respiratory syndrome virus replication by adenovirus-mediated RNA interference both in porcine alveolar macrophages and swine
    Guangming Li
    Ministry of Agriculture, Nanjing Agriculture University, Jiangsu, China
    Antiviral Res 82:157-65. 2009
    ..One recombinant adenovirus (rAd-P2) was found to be also effective in inhibiting the replication of highly virulent PRRSV SY0608 strain in Marc-145 ..
  35. pmc Yttrium-90 ibritumomab tiuxetan doses calculated to deliver up to 15 Gy to critical organs may be safely combined with high-dose BEAM and autologous transplantation in relapsed or refractory B-cell non-Hodgkin's lymphoma
    Jane N Winter
    Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Clin Oncol 27:1653-9. 2009
    To determine the maximum-tolerated radiation-absorbed dose (RAD) to critical organs delivered by yttrium-90 ((90)Y) ibritumomab tiuxetan in combination with high-dose carmustine, etoposide, cytarabine, and melphalan (BEAM) chemotherapy ..
  36. ncbi Muscle fatigue induced by exercise simulating the work rate of competitive soccer
    N Rahnama
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    J Sports Sci 21:933-42. 2003
    ..001) in peak torque for both the quadriceps and hamstrings at all angular velocities (concentric: 1.05, 2.09, 5.23 rad x s(-1); eccentric: 2.09 rad x s(-1))...
  37. ncbi Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease
    A J Bardwell
    Laboratory of Molecular Pathology, University of Texas Southwestern Medical Center at Dallas 75235
    Science 265:2082-5. 1994
    The RAD1 and RAD10 genes of Saccharomyces cerevisiae are required for both nucleotide excision repair and certain mitotic recombination events...
  38. ncbi In vivo radioprotective effects of oltipraz in gamma-irradiated mice
    S G Kim
    College of Pharmacy, Duksung Women s University, Seoul, Korea
    Biochem Pharmacol 55:1585-90. 1998
    Previous studies in this laboratory have shown that oltipraz (Olt), a chemopreventive agent, enhances radiation(Rad)-inducible glutathione S-transferase (GST) and microsomal epoxide hydrolase (mEH) expression in the liver...
  39. ncbi Tissue engineering of a bioartificial renal tubule assist device: in vitro transport and metabolic characteristics
    H D Humes
    Department of Internal Medicine, University of Michigan, VA Medical Center, Ann Arbor, USA
    Kidney Int 55:2502-14. 1999
    ..This therapy is not complete renal replacement therapy because it does not provide active transport nor metabolic and endocrinologic functions of the kidney, which are located predominantly in the tubular elements of the kidney...
  40. ncbi Antioxidant properties of ursodeoxycholic acid
    Domenico Lapenna
    Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, 66100 Scalo, Chieti, Italy
    Biochem Pharmacol 64:1661-7. 2002
    ..09 and 29 mM, respectively, in human plasma and bile. UDCA was an excellent scavenger of OHz.rad; generated by FeCl(3)-EDTA, H(2)O(2) and ascorbate in the deoxyribose oxidation test, showing IC(min) and IC(50) ..
  41. ncbi Bone or cartilage invasion by advanced head and neck cancer: intra-arterial supradose cisplatin chemotherapy and concomitant radiotherapy for organ preservation
    S Samant
    Department of Otolaryngology Head and Neck Surgery, University of Tennessee Health Sciences Center, 956 Court Ave, Suite B 222, Memphis, TN 38163, USA
    Arch Otolaryngol Head Neck Surg 127:1451-6. 2001
    ..At University of Tennessee-Memphis, patients with advanced head and neck cancer have been treated on a protocol of concomitant intra-arterial (targeted) cisplatin and conventional radiation therapy...
  42. doi Histopathological and scintigraphic comparisons of the protective effects of L-carnitine and amifostine against radiation-induced late renal toxicity in rats
    Murat Caloglu
    Department of Radiation Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Clin Exp Pharmacol Physiol 36:523-30. 2009
    ..2. Seventy-one Albino rats were randomly divided into six groups as follows: (i) AMI + RAD (n = 15), 200 mg/kg, i.p...
  43. ncbi A comparison of three site-directed mutagenesis kits
    P Loke
    Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore
    Z Naturforsch C 56:810-3. 2001
    ..comparative study, three different mutagenesis kits, namely the MutaGene phagemid in vitro mutagenesis kit (Bio-Rad), the Transformerä Site-Directed mutagenesis kit (Clontech) and the Quik-change site-directed mutagenesis kit (..
  44. ncbi Rad is temporally regulated within myogenic progenitor cells during skeletal muscle regeneration
    Thomas J Hawke
    School of Kinesiology and Health Science, York Univ, 4700 Keele St, Toronto, ON, Canada M3J 1P3
    Am J Physiol Cell Physiol 290:C379-87. 2006
    ..Herein we demonstrate the expression pattern and transcriptional regulation of Rad, a prototypical member of a family of novel Ras-related GTPases, during mammalian development and skeletal muscle ..
  45. ncbi Gender differences in the circadian variations in muscle strength assessed with and without superimposed electrical twitches
    Magali Giacomoni
    Laboratoire Ergonomie Sportive et Performance, UFR STAPS, Universite de Toulon Var, La Garde, France
    Ergonomics 48:1473-87. 2005
    ..Peak isokinetic torques (PT) of knee extensors and flexors were then measured at 1.05 rad s(-1) and 3.14 rad s(-1) through a 90 degrees range of motion...
  46. ncbi Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low
    B Hausen
    Transplantation Immunology, Department of Cardiothoracic Surgery, Stanford University, Palo Alto, California 94305, USA
    Transplantation 69:488-96. 2000
    ..but reduced tolerability after combined treatment with high doses of microemulsion cyclosporine (CsA) and SDZ RAD (40-O-(2-hydroxyethyl)-rapamycin)...
  47. doi Efficient adenovirus-mediated gene transfer to gastric tissue by oral administration
    Xiao fei Liu
    Department of Clinical Microbiology and Immunology, Third Military Medical University, Chongqing, China
    J Gene Med 11:1087-94. 2009
    Recombinant adenoviruses (rAd) are well-characterized viral vectors and have been studied in many human diseases. However, there are no detailed methods for transferring genes to the stomach using rAd.
  48. doi An evaluation of two commercially available ELISAs and one in-house reference laboratory ELISA for the determination of human anti-rabies virus antibodies
    Ryan J Welch
    Associated Regional and University Pathologists ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
    J Med Microbiol 58:806-10. 2009
    ..We compared the Bio-Rad Platelia Rabies II ELISA, DRG Rabies Virus IgG Ab ELISA and Focus Diagnostics Rabies Antibody Detection by ELISA to ..
  49. ncbi ESR dating of elephant teeth and radiation dose rate estimation in soil
    T S Chong
    Department of Nuclear Engineering, Nagoya University, Japan
    Int J Rad Appl Instrum A 40:1199-202. 1989
    ..The 60Co gamma-ray equivalent accumulated dose of (2 +/- 0.2) x 10(4) rad for the tooth enamel gave "ESR age" of (9 +/- 2) x 10(4) y, which falls in the geologically estimated range between ..
  50. ncbi Comparison of genotoxic potency of styrene 7,8-oxide with gamma radiation and human cancer risk estimation of styrene using the rad-equivalence approach
    Lode Godderis
    IDEWE, External Service for Prevention at Work, Interleuvenlaan 58, 3001 Heverlee, Belgium
    Mutagenesis 22:209-15. 2007
    ..genotoxic potency of styrene 7,8-oxide and gamma radiation in order to calculate the cancer risk by means of the rad-equivalence approach. Leucocytes of 20 individuals were exposed to 0, 0.1, 0.2 or 0...
  51. ncbi Neonatal thymulin gene therapy in nude mice: Effects on the morphology of the pituitary corticotrope population
    Eliana Martines
    Department of Cytology, Histology and Embryology, Faculty of Medicine, National University of La Plata, Argentina
    Histol Histopathol 26:471-9. 2011
    ..We used an adenoviral vector expressing a synthetic gene for the thymic peptide thymulin (metFTS) termed RAd-FTS...
  52. doi A comprehensive index for assessing environmental stress in animals
    T L Mader
    Department of Animal Science, University of Nebraska, Concord 68728, USA
    J Anim Sci 88:2153-65. 2010
    ..However, no model has been found that incorporates adjustments for RH, WS, and radiation (RAD) over conditions that encompass hot and cold environmental conditions...
  53. doi HSP70 fused with GP3 and GP5 of porcine reproductive and respiratory syndrome virus enhanced the immune responses and protective efficacy against virulent PRRSV challenge in pigs
    Junxing Li
    Nanjing Agricultural University, Nanjing 210095, China
    Vaccine 27:825-32. 2009
    ..The results showed that all animals vaccinated with rAd-GP35 (co-expressing GP3-GP5), rAd-HS35 and rAd-HSA35 (co-expressing GP3-GP5 fused with HSP70 using different ..
  54. ncbi Synergism between base excision repair, mediated by the DNA glycosylases Ntg1 and Ntg2, and nucleotide excision repair in the removal of oxidatively damaged DNA bases in Saccharomyces cerevisiae
    L Gellon
    CEA, Departement de Radiobiologie et Radiopathologie, UMR217 CNRS CEA Radiobiologie Moléculaire et Cellulaire, Fontenay aux Roses, France
    Mol Genet Genomics 265:1087-96. 2001
    ..The triple mutants rad1 ntg1 ntg2 and rad14 ntg1 ntg2 show 15- and 22-fold increases, respectively, in spontaneous forward mutation to ..
  55. ncbi Influence of muscle architecture on the torque and power-velocity characteristics of young and elderly men
    Jeanette M Thom
    Institute for Biophysical and Clinical Research into Human Movement IRM, Manchester Metropolitan University, Alsager Campus, Hassall Road, Alsager, Cheshire, ST7 2HL, UK
    Eur J Appl Physiol 100:613-9. 2007
    ..Plantarflexors' (PF) maximal isometric and concentric torques were recorded at 0.87, 1.75, 2.62, 3.49 and 4.36 rad s(-1)...
  56. ncbi The novel immunosuppressant FTY720 induces peripheral lymphodepletion of both T- and B-cells in cynomolgus monkeys when given alone, with Cyclosporine Neoral or with RAD
    V F Quesniaux
    Transplantation Research Department, Novartis Pharma, Basel, Switzerland
    Transpl Immunol 8:177-87. 2000
    ..Here, we investigated the susceptibility of cynomolgus monkeys to FTY720 given orally either alone or in combination with two other immunosuppressants, Cyclosporin Neoral or RAD, as an introductory study to transplantation protocols.
  57. ncbi [Noninvasive assessment of forearm vessels by color Doppler ultrasonography (CDU) before and after radiocephalic fistula (RCF) placement]
    R Roca-Tey
    Servicio de Nefrologia, Hospital de Mollet, Barcelona
    Nefrologia 27:489-95. 2007
    ..The CDU is a noninvasive vascular access (VA) monitoring technique that provides both structural and hemodynamic information from vessels...
  58. ncbi Immune responses of two recombinant adenoviruses expressing VP1 antigens of FMDV fused with porcine granulocyte macrophage colony-stimulating factor
    Yijun Du
    Key Laboratory of Animal Diseases Diagnostic and Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Ministry of Agriculture, Nanjing 210095, China
    Vaccine 25:8209-19. 2007
    ..designated VPe) or VP1 protein of FMDV fused with porcine granulocyte macrophage colony-stimulating factor (named rAd-GMCSF-VPe and rAd-GMCSF-VP1)...
  59. ncbi Reference database for bone speed of sound measurement by a novel quantitative multi-site ultrasound device
    M Weiss
    Endocrine Institute, Assaf Harofeh Medical Center, Zerifin, Israel
    Osteoporos Int 11:688-96. 2000
    ..We report the reference database for SOS at the radius (RAD), tibia (TIB), metatarsus (MTR) and phalanx (PLX)...
  60. doi Protective immune responses induced by in ovo immunization with recombinant adenoviruses expressing spike (S1) glycoprotein of infectious bronchitis virus fused/co-administered with granulocyte-macrophage colony stimulating factor
    Basit Zeshan
    Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
    Vet Microbiol 148:8-17. 2011
    ..The results showed that the chickens vaccinated in ovo with rAd-S1, rAd-GM-S1 (GM-CSF fused with S1 using glycine linkers) and rAd-GM-CSF plus rAd-S1 (co-administered) developed ..
  61. ncbi Retinal microvascular abnormalities in patients treated with external radiation for graves ophthalmopathy
    Dennis M Robertson
    Department of Ophthalmology, Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Ophthalmol 121:652-7. 2003
    ..Radiation was directed to the orbits of 42 affected patients using 0.2 rad (20 Gy) delivered in 10 doses of 0.02 rad (2 Gy). Patients were periodically examined during a 3-year interval.
  62. ncbi Inhibition of metabolism and growth of Mycobacterium leprae by gamma irradiation
    L B Adams
    Laboratory Research Branch, GWL Hansen s Disease Center, Louisiana State University, Baton Rouge 70894, USA
    Int J Lepr Other Mycobact Dis 68:1-10. 2000
    ..gamma-Irr of up to 10(3) rad had little effect on the metabolic activity of either organism. For M...
  63. pmc Regulation of seed germination in the close Arabidopsis relative Lepidium sativum: a global tissue-specific transcript analysis
    Karl Morris
    School of Life Sciences, Warwick University, Wellesbourne, Warwick CV35 9EF, United Kingdom
    Plant Physiol 155:1851-70. 2011
    ..g. Arabidopsis [Arabidopsis thaliana]) is regulated by two opposing forces, the growth potential of the radicle (RAD) and the resistance to this growth from the micropylar endosperm cap (CAP) surrounding it...
  64. pmc Rsp5, a ubiquitin-protein ligase, is involved in degradation of the single-stranded-DNA binding protein rfa1 in Saccharomyces cerevisiae
    N Erdeniz
    Department of Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032 2704, USA
    Mol Cell Biol 20:224-32. 2000
    In Saccharomyces cerevisiae, RAD1 and RAD52 are required for alternate pathways of mitotic recombination. Double-mutant strains exhibit a synergistic interaction that decreases direct repeat recombination rates dramatically...
  65. pmc Genetic control of RNA polymerase I-stimulated recombination in yeast
    B R Zehfus
    Department of Biological Chemistry, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033
    Genetics 126:41-52. 1990
    ..Mutations in RAD1 and RAD52 decrease the ability of HOT1 to stimulate intrachromosomal recombination while mutations in RAD4 and ..
  66. ncbi Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport
    Ramasubbu N Mahalakshmi
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Traffic 8:1164-78. 2007
    The members of the RGK small GTP-binding protein family, Kir/Gem, Rad, Rem and Rem2, are multifunctional proteins that regulate voltage-gated calcium channel activity and cell shape remodeling...
  67. ncbi Reduced orthostatic tolerance following 4 h head-down tilt
    G C Butler
    Department of Kinesiology, University of Waterloo, Ontario, Canada
    Eur J Appl Physiol Occup Physiol 62:26-30. 1991
    The cardiovascular responses to a 10-min 1.22 rad (70 degrees) head-up tilt orthostatic tolerance test (OST) was observed in eight healthy men following each of a 5-min supine baseline (control), 4 h of 0...
  68. ncbi [Construction and immunogenicity of a recombinant adenovirus co-expressing the E2 protein of classical swine fever virus and the porcine interleukin 2 in rabbits]
    Lei He
    College of Veterinary Medicine, Northwest A and F University, Yangling 712100, China
    Bing Du Xue Bao 26:385-91. 2010
    ..resultant recombinant plasmid AdEasy-E2-pIL-2 was transfected into the 293 cells where the recombinant adenovirus rAd-E2-pIL-2 was produced. The immunogenicity of rAd-E2-pIL-2 was evaluated in rabbits...
  69. ncbi Histamine inactivation in the colon of pigs in relationship to abundance of catabolic enzymes
    Jörg R Aschenbach
    Institute of Veterinary Physiology, University of Leipzig, Leipzig, Germany
    Scand J Gastroenterol 41:712-9. 2006
    ..Two enzymes are involved, namely histamine N-methyltransferase (HMT) and diamine oxidase (DAO). The purpose of this study was to find a link between histamine catabolism and the activities of HMT and DAO...
  70. ncbi Non-nociceptive upper limb afferents modulate masseter muscle EMG activity in man
    Franca Deriu
    Department of Biomedical Sciences, Section of Human Physiology and Bioengineering, University of Sassari, Viale San Pietro 43 B, 07100 Sassari, Italy
    Exp Brain Res 143:286-94. 2002
    ..human masseter muscles by stimulation of non-nociceptive fibres travelling in the median and radial nerves (MED and RAD, respectively). Eighteen healthy volunteers participated in the study...
  71. ncbi Use of yeast for detection of endogenous abasic lesions, their source, and their repair
    Serge Boiteux
    Laboratory of Radiobiology DNA, Department of Radiobiology and Radiopathology, Aus Roses, France
    Methods Enzymol 408:79-91. 2006
    ..Data shows that the simultaneous inactivation of two AP endonucleases (Apn1 and Apn2) and of the nuclease Rad1-Rad10 causes cell death in Saccharomyces cerevisiae...
  72. ncbi Inoperable hepatocellular carcinoma: transarterial 188Re HDD-labeled iodized oil for treatment--prospective multicenter clinical trial
    Ajay Kumar
    Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Radiology 243:509-19. 2007
    ....
  73. ncbi Role of interleukin-1 receptor type II in the pathogenesis of endometriosis
    Zhen Hou
    Center of Clinical Reproductive Medicine, Department of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing, People s Republic of China
    Fertil Steril 89:42-51. 2008
    ..To determine the role of interleukin-1 receptor type II (IL-1RII) in the pathogenesis of endometriosis...
  74. doi Comparison between multiplex assays for autoantibody detection in systemic lupus erythematosus
    John G Hanly
    Division of Rheumatology, Capital Health and Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol Methods 358:75-80. 2010
    ..Autoantibodies were measured using the BioPlex 2200 ANA screen (Bio-Rad), QuantaPlex ENA8 (INOVA Diagnostics) and recomLine ANA/ENA (Mikrogen)...
  75. ncbi Influence of 5,10-methylenetetrahydrofolate reductase polymorphism on whole-blood folate concentrations measured by LC-MS/MS, microbiologic assay, and bio-rad radioassay
    Zia Fazili
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30345, USA
    Clin Chem 54:197-201. 2008
    ..NADPH) (MTHFR) C677T polymorphism may affect whole-blood folate pattern measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and total folate measured by LC-MS/MS, microbiologic assay, and Bio-Rad radioassay (BR).
  76. doi Analysis of the serum levels of fungi-specific immunoglobulin E in patients with allergic diseases
    Feng Ying Chang
    Department of Pediatrics, Shin Kong Wu Ho Su Memorial Hospital, 7 Chung Shan South Road, Taipei, Taiwan, Republic of China
    Int Arch Allergy Immunol 154:49-56. 2011
    ..Sensitization to fungal allergens may be associated with respiratory allergic disease (RAD) and atopic dermatitis (AD)...
  77. ncbi Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling
    James D Ramsden
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Endocrinology 146:2895-902. 2005
    ..Recombinant adenovirus vectors (RAds) expressing truncated, secreted forms of human Tie2 (RAd-sTie2) and vascular endothelial growth factor receptor 1 (RAd-sVEGFR1) or a truncated, dominant-negative fibroblast ..
  78. ncbi A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease
    A E Parker
    Department of Experimental Molecular Biology, Janssen Research Foundation, Turnhoutseweg 30, B 2340 Beerse, Belgium
    J Biol Chem 273:18332-9. 1998
    In the fission yeast Schizosaccharomyces pombe the rad1(+) gene is required for both the DNA damage-dependent and the DNA replication-dependent cell cycle checkpoints. We have identified a human homologue of the S...
  79. ncbi Analysis of immunogenicity of minor envelope protein GP3 of porcine reproductive and respiratory syndrome virus in mice
    Wenming Jiang
    Key Laboratory of Animal Diseases Diagnostic and Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Ministry of Agriculture, Nanjing 210095, China
    Virus Genes 35:695-704. 2007
    ..In this study, two recombinant adenoviruses, rAd-GP3 expressing complete GP3 and rAd-tGP3 expressing truncated GP3 in which aa2-64 were deleted, were constructed ..
  80. pmc The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair
    Magali Toueille
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich Irchel, Wintherturerstrasse 190, CH 8057, Zurich, Switzerland
    Nucleic Acids Res 32:3316-24. 2004
    ..This requires the action of DNA damage sensors such as the Rad family proteins. The three human proteins Rad9, Rad1 and Hus1 form a heterotrimeric complex (called the 9-1-1 complex) that is recruited onto DNA upon damage...
  81. doi Antitumor effects of murine bone marrow-derived dendritic cells infected with xenogeneic livin alpha recombinant adenoviral vectors against Lewis lung carcinoma
    Junping Xie
    Department of Respiratory Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Lung Cancer 68:338-45. 2010
    Transduction with recombinant, replication-defective adenoviral (rAd) vectors encoding a transgene is an efficient method for gene transfer into dendritic cells (DCs). Livin is a member of the inhibitor of apoptosis protein family...
  82. ncbi High-performance liquid chromatographic determination of dietary fibre in raw and processed carrots
    A Redondo
    , Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    J Chromatogr A 677:273-8. 1994
    ..414 M H2SO4 for 3 h at 100 degrees C. For the neutralization step prior to injection, AG4-X4 resin (Bio-Rad) was used. Neutral monosaccharides were separated using an HPX-87P column (Bio-Rad)...
  83. ncbi Theoretical concepts of on-line liquid chromatographic-biochemical detection systems. I. Detection systems based on labelled ligands
    A J Oosterkamp
    Leiden/Amsterdam Center for Drug Research, University of Leiden, The Netherlands
    J Chromatogr A 787:27-35. 1997
    ..Using a recently developed LC-receptor affinity detection (RAD) system as a model, equations are derived which describe the detector response and the signal-to-noise ratio as a ..
  84. ncbi Polarography of Walker tumor submitted to radiotherapy
    M Sakate
    Universidade Estadual Paulista, UNESP, Campus de Botucatu Faculdade de Medicina, Departamento de Radioterapia
    Tumori 73:555-8. 1987
    ..Tumor growth caused a decrease in tumoral oxygen. Oxygen was always lower in the tumor than in the muscle. Radiotherapy with 2000 rad (but not with 1000 rad) increased oxygen in the tumor.
  85. pmc Floral asymmetry involves an interplay between TCP and MYB transcription factors in Antirrhinum
    Susie B Corley
    Department of Cell and Developmental Biology, John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 102:5068-73. 2005
    To understand how genes control floral asymmetry, we have isolated and analyzed the role of the RADIALIS (RAD) gene in Antirrhinum...
  86. doi Potent inhibition of L-type Ca2+ currents by a Rad variant associated with congestive heart failure
    U Meza
    Department of Medicine Cardiology Division, University of Colorado Denver Anschutz Medical Campus, 12700 East 19th Avenue, P15 8006, B 139, Aurora, CO 80045, USA Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad Autonoma de San Luis Potosi, Venustiano Carranza 2405, San Luis Potosi, SLP 78210, Mexico Electronic address
    Biochem Biophys Res Commun 439:270-4. 2013
    ..b>Rad, a member of the RGK (Rem, Rem2, Rad, Gem/Kir) family of monomeric G proteins, regulates ventricular action ..
  87. ncbi Evaluation of regional aortic distensibility using color kinesis
    Yoshimasa Kato
    First Department of Surgery, Toyama Medical and Pharmaceutical University, Toyama shi, Toyama, Japan
    Angiology 54:345-51. 2003
    ..The authors defined regional aortic distensibility (RAD) by considering pulse pressure, with RAD (microm/s/mm Hg) = (regional aortic wall velocity)/(pulse pressure)...
  88. ncbi Application of the Cre/loxP system to enhance thyroid-targeted expression of sodium/iodide symporter
    Xiaoqin Lin
    Department of Physiology and Cell Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 89:2344-50. 2004
    ..The following three recombinant adenoviruses (rAd) were constructed: rAd-Tg-hNIS drives hNIS expression by the Tg promoter; rAd-Tg-Cre drives Cre expression by the ..
  89. doi Immunohistochemistry as an adjunct in the differential diagnosis of radiation-induced atypia versus urothelial carcinoma in situ of the bladder: a study of 45 cases
    Esther Oliva
    Pathology Department, Massachusetts General Hospital, Boston, MA 02118, USA
    Hum Pathol 44:860-6. 2013
    ..In this setting, radiation-induced changes (RAD-Ch) may be very difficult to distinguish from carcinoma in situ, and failing to recognize them may lead to ..
  90. pmc Is RAD-seq suitable for phylogenetic inference? An in silico assessment and optimization
    Marie Cariou
    Universite de Lyon, Universite Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive 43 boulevard du 11 novembre 1918, Villeurbanne, F 69622, France
    Ecol Evol 3:846-52. 2013
    ..In this context, Restriction site Associated DNA sequencing (RAD-seq) seems promising as this technique can generate sequence data from numerous DNA fragments scattered throughout ..
  91. doi Do ray cells provide a pathway for radial water movement in the stems of conifer trees?
    David M Barnard
    Department of Forest Ecosystems and Society, Oregon State University Corvallis, OR 97331 USA
    Am J Bot 100:322-31. 2013
    ..This study investigated relationships between radial hydraulic conductivity (k(s-rad)) and ray anatomical and stem morphological characteristics in the stems of three conifer species whose ..
  92. doi Recombinant adenovirus expressing F and H fusion proteins of peste des petits ruminants virus induces both humoral and cell-mediated immune responses in goats
    Yong Wang
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No 2 Yuanmingyuan West Road, Beijing 100193, PR China
    Vet Immunol Immunopathol 154:1-7. 2013
    ..The recombinant adenoviruses (rAds) expressing F, H, and F-H fusion protein were named rAd-F, rAd-H, and rAd-F-H, respectively...
  93. ncbi Rapid-air-dry papanicolaou stain in canine and feline tumor cytology: a quantitative comparison with the Giemsa stain
    Mariko Sawa
    Laboratory of Veterinary Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, Kagoshima 890 0065, Japan
    J Vet Med Sci 74:1133-8. 2012
    ..stain using air-dried smears is utilized in human cytology, but usefulness of this rapid-air-dry Papanicolaou (RAD-Pap) stain in the veterinary field has not been fully evaluated...
  94. doi Social use of language in children with reactive attachment disorder and autism spectrum disorders
    Fareeha Amber Sadiq
    Section of Psychological Medicine, Caledonia House, Royal Hospital for Sick Children, University of Glasgow, Glasgow, UK
    Eur Child Adolesc Psychiatry 21:267-76. 2012
    Children with a diagnosis of reactive attachment disorder (RAD) appear to show difficulties in social understanding. We aimed to compare the pragmatic language functioning of children with (RAD) and autism spectrum disorder (ASD)...
  95. doi Synergistic anticancer effect of rAd/P53 combined with 5-fluorouracil or iodized oil in the early therapeutic response of human colon cancer in vivo
    Qi Xie
    Department of Imaging, Nan Sha Center Hospital, Guangzhou Municipal First People s Hospital, Guangzhou Medical College, Guangzhou 510240, Guangdong Province, China
    Gene 499:303-8. 2012
    ..In the present study, the early therapeutic response of rAd/p53, combined with 5-fluorouracil (5-FU) or with iodized oil, was observed in a human colon cancer model...
  96. pmc Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke
    Issei S Shimada
    Department of Medicine, Stem Cell Core, University of Vermont, Colchester, Vermont 05446, USA
    J Neurosci 32:7926-40. 2012
    ..neural spheres in culture, suggestive of tdRFP-positive reactive astrocyte-derived neural stem/progenitor cells (Rad-NSCs). Cultured Rad-NSCs self-renewed and differentiated into neurons, astrocytes, and oligodendrocytes...
  97. pmc Inferring phylogenies from RAD sequence data
    Benjamin E R Rubin
    Committee on Evolutionary Biology, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e33394. 2012
    ..g., Illumina, SOLiD) to sequence restriction-site associated DNA (RAD)--the regions of the genome that flank the recognition sites of restriction enzymes...
  98. doi Population genomic analysis of model and nonmodel organisms using sequenced RAD tags
    PAUL A HOHENLOHE
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR, USA
    Methods Mol Biol 888:235-60. 2012
    ..To speed this revolution in evolutionary genetics, we and colleagues developed Restriction site Associated DNA (RAD) sequencing, a method that uses Illumina NGS to simultaneously type and score tens to hundreds of thousands of ..
  99. ncbi Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II
    J S Moyers
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 272:11832-9. 1997
    Members of the Rad family of GTPases (including Rad, Gem, and Kir) possess several unique features of unknown function in comparison to other Ras-like proteins, with major N-terminal and C-terminal extensions, a lack of typical ..
  100. ncbi Resistance exercise prevents plantar flexor deconditioning during bed rest
    M M Bamman
    Department of Human Studies, University of Alabama at Birmingham 35294, USA
    Med Sci Sports Exerc 29:1462-8. 1997
    ..The angle-specific torque-velocity relationship across 5 velocities (0, 0.52, 1.05, 1.75, and 2.97 rad.s-1) and the full range-of-motion power-velocity relationship were assessed on a dynamometer...
  101. pmc Polarization of protective immunity induced by replication-incompetent adenovirus expressing glycoproteins of pseudorabies virus
    Young Woo Han
    Laboratory of Microbiology, College of Veterinary Medicine and Bio Safety Research Institute, Chonbuk National University, Jeonju 561 756, Korea
    Exp Mol Med 40:583-95. 2008
    ..Among three constructs, recombinant adenovirus expressing gB (rAd-gB) was found to induce the most potent immunity biased to Th1-type, as determined by the IgG isotype ratio and the ..

Research Grants65

  1. DNA REPAIR IN A HORMONE RESPONSIVE GENE
    Michael J Smerdon; Fiscal Year: 2010
    ..Pol II genes and ribosomal RNA genes (Pol I) of lrs mutants of repair proficient (wt) and repair deficient (rad) cells...
  2. DNA REPAIR IN A HORMONE RESPONSIVE GENE
    Michael J Smerdon; Fiscal Year: 2011
    ..Pol II genes and ribosomal RNA genes (Pol I) of lrs mutants of repair proficient (wt) and repair deficient (rad) cells...
  3. DNA REPAIR IN A HORMONE RESPONSIVE GENE
    Michael Smerdon; Fiscal Year: 1999
    ..a model chromatin substrate to study transcription-coupled repair in repair proficient (wt) and repair deficient (rad-) yeast cells...
  4. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..double-blinded clinical trial including patients from the UW-Madison is underway to see if a form of rapamycin (RAD) can prevent bronchiolitis obliterans syndrome (BOS) while improving long-term outcome in lung transplants...
  5. Brain Motion During Blunt Impact
    Albert King; Fiscal Year: 2007
    ..However, the range of angular velocities used was limited to approximately 25 rad/s...
  6. Repair of Oxidatively Damaged Guanines
    A LIEN L LU CHANG; Fiscal Year: 2010
    ..interacts with the DNA replication machinery, other repair enzymes, the 9-1-1 cell cycle checkpoint complex (Rad9/Rad1/Hus1), and the aging regulator SIRT6...
  7. Programming Airway Epithelial Differentiation by Rad
    Reen Wu; Fiscal Year: 2007
    ..We undertook a study to determine whether Rad, whose expression is induced by vitamin A deficiency, modulates airway squamous cell differentiation, such as the ..
  8. Repair of Oxidatively Damaged Guanines
    A LIEN L LU CHANG; Fiscal Year: 2010
    ..interacts with the DNA replication machinery, other repair enzymes, the 9-1-1 cell cycle checkpoint complex (Rad9/Rad1/Hus1), and the aging regulator SIRT6...
  9. Lipid Carriers in Membrane Glycoproteins
    William Lennarz; Fiscal Year: 2006
    ..With respect to PNGase, it has been observed that it interacts with the proteosome via only one protein, Rad 23p...
  10. GENE EXPRESSION IN DIABETES BY SUBTRACTIVE CLONING
    C Kahn; Fiscal Year: 2000
    ..of the mitochondrial genome, elongation factor 1alpha, geranylgeranyl pyrophosphate synthase, and the novel GTPase Rad. We have also identified variations in two candidate genes for Type 2 diabetes that can influence the expression of ..
  11. PROTEOMEWORKSTM SYSTEM
    Richard Cook; Fiscal Year: 2001
    This Shared Instrumentation Grant proposal is for the purchase of the ProteomeWorks(TM) System from BIO-RAD and Micromass...
  12. Urokinase Receptor-initiated Cell-Signaling
    STEVEN GONIAS; Fiscal Year: 2009
    ..uPA-binding activates ERK/MAP kinase whereas vitronectin activates Rad. Other signaling proteins, such as STAT-5b, may be recruited downstream of uPAR depending on the co-receptors that ..
  13. Urokinase Receptor-initiated Cell-Signaling
    Steven L Gonias; Fiscal Year: 2010
    ..uPA-binding activates ERK/MAP kinase whereas vitronectin activates Rad. Other signaling proteins, such as STAT-5b, may be recruited downstream of uPAR depending on the co-receptors that ..
  14. Urokinase Receptor-initiated Cell-Signaling
    STEVEN GONIAS; Fiscal Year: 2009
    ..uPA-binding activates ERK/MAP kinase whereas vitronectin activates Rad. Other signaling proteins, such as STAT-5b, may be recruited downstream of uPAR depending on the co-receptors that ..