Gene Symbol: RPS6KA5
Description: ribosomal protein S6 kinase A5
Alias: MSK1, MSPK1, RLPK, ribosomal protein S6 kinase alpha-5, 90 kDa ribosomal protein S6 kinase 5, RSK-like protein kinase, RSKL, S6K-alpha-5, nuclear mitogen- and stress-activated protein kinase 1, ribosomal protein S6 kinase, 90kDa, polypeptide 5
Species: human
Products:     RPS6KA5

Top Publications

  1. Reber L, Vermeulen L, Haegeman G, Frossard N. Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation. PLoS ONE. 2009;4:e4393 pubmed publisher
    ..We show here that the MAPK downstream nuclear kinase MSK1 induces NF-kappaB p65 Ser276 phosphorylation upon IL-1beta treatment, which was inhibited in cells transfected with ..
  2. Soloaga A, Thomson S, Wiggin G, Rampersaud N, Dyson M, Hazzalin C, et al. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J. 2003;22:2788-97 pubmed
    ..Further more, we show that histone H3 and HMG-14 phosphorylation is severely reduced or abolished in mice lacking MSK1 and MSK2...
  3. Joo J, Jetten A. NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. J Biol Chem. 2008;283:16391-9 pubmed publisher
    ..We further show that inhibition of MSK1, a kinase acting downstream of MEK1/2-ERK1/2, by H89 or knockdown of MSK1 expression also inhibited phosphorylation ..
  4. Janknecht R. Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). Oncogene. 2003;22:746-55 pubmed
    ..Here, mitogen- and stress-activated protein kinase 1 (MSK1), which itself is directly activated by distinct classes of MAPKs, is identified to regulate ER81 function...
  5. Sundar I, Chung S, Hwang J, Lapek J, Bulger M, Friedman A, et al. Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-?B-dependent genes. PLoS ONE. 2012;7:e31378 pubmed publisher
    ..Mitogen- and stress-activated kinase 1 (MSK1) serves as a specific downstream NF-?B RelA/p65 kinase, mediating transcriptional activation of NF-?B-dependent pro-..
  6. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J. 2003;22:1313-24 pubmed
    ..inhibitors SB203580 and PD98059 or U0126, as well as a potent mitogen- and stress- activated protein kinase-1 (MSK1) inhibitor H89, counteract tumor necrosis factor (TNF)-mediated stimulation of p65 transactivation capacity...
  7. McCoy C, Campbell D, Deak M, Bloomberg G, Arthur J. MSK1 activity is controlled by multiple phosphorylation sites. Biochem J. 2005;387:507-17 pubmed
    b>MSK1 (mitogen- and stress-activated protein kinase) is a kinase activated in cells downstream of both the ERK1/2 (extracellular-signal-regulated kinase) and p38 MAPK (mitogen-activated protein kinase) cascades...
  8. Deak M, Clifton A, Lucocq L, Alessi D. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998;17:4426-41 pubmed
    We have identified a novel mitogen- and stress-activated protein kinase (MSK1) that contains two protein kinase domains in a single polypeptide. MSK1 is activated in vitro by MAPK2/ERK2 or SAPK2/p38...
  9. Kannan Thulasiraman P, Katsoulidis E, Tallman M, Arthur J, Platanias L. Activation of the mitogen- and stress-activated kinase 1 by arsenic trioxide. J Biol Chem. 2006;281:22446-52 pubmed
    ..We provide evidence that As2O3 induces activation of the mitogen- and stress-activated kinase 1 (MSK1) and downstream phosphorylation of its substrate, histone H3, in leukemia cell lines...

More Information

Publications156 found, 100 shown here

  1. McCoy C, Macdonald A, Morrice N, Campbell D, Deak M, Toth R, et al. Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. Biochem J. 2007;402:491-501 pubmed
    b>MSK1 (mitogen- and stress-activated kinase 1) is a dual kinase domain protein that acts downstream of the ERK1/2 (extracellular-signal-regulated kinase 1/2) and p38 MAPK (mitogen-activated protein kinase) signalling pathways in cells...
  2. Arthur J. MSK activation and physiological roles. Front Biosci. 2008;13:5866-79 pubmed
    ..The physiological roles of MSKs still remain to be completely determined, however recent work has suggested a role for MSKs in neuronal synaptic plasticity and in regulating cytokine production in the innate immune system. ..
  3. Beck I, Vanden Berghe W, Vermeulen L, Bougarne N, Vander Cruyssen B, Haegeman G, et al. Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition. EMBO J. 2008;27:1682-93 pubmed publisher
    ..found that glucocorticoids counteract the recruitment of activated Mitogen- and Stress-activated protein Kinase-1 (MSK1) at inflammatory gene promoters resulting in the inhibition of NF-kappaB p65 transactivation and of concurrent ..
  4. Thomson S, Clayton A, Hazzalin C, Rose S, Barratt M, Mahadevan L. The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. EMBO J. 1999;18:4779-93 pubmed
    ..b>MSK1 is considered the most likely kinase to mediate this response because (i) it is activated by both ERK and p38 MAPKs;..
  5. Wiggin G, Soloaga A, Foster J, Murray Tait V, Cohen P, Arthur J. MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol. 2002;22:2871-81 pubmed
    Using mouse knockouts for mitogen- and stress-activated protein kinase 1 (MSK1) and MSK2 and a double knockout of both MSK1 and MSK2, we show that these protein kinases are required for the stress-induced phosphorylation of transcription ..
  6. Markou T, Lazou A. Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase. Biochem J. 2002;365:757-63 pubmed
    ..We examined the activation of mitogen- and stress-activated protein kinase-1 (MSK1), a downstream target of MAPKs, in adult rat cardiac myocytes by phenylephrine and endothelin-1...
  7. Jacks K, Koch C. Differential regulation of mitogen- and stress-activated protein kinase-1 and -2 (MSK1 and MSK2) by CK2 following UV radiation. J Biol Chem. 2010;285:1661-70 pubmed publisher
    Mitogen- and stress-activated protein kinases, MSK1 and the closely related isoform MSK2, are nuclear kinases that are activated following mitogen stimulation or cellular stress, including UV radiation, by the ERK1/2 and p38 MAPK ..
  8. Drobic B, Perez Cadahia B, Yu J, Kung S, Davie J. Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex. Nucleic Acids Res. 2010;38:3196-208 pubmed publisher
    Upon activation of the ERK and p38 MAPK pathways, the MSK1/2-mediated nucleosomal response, including H3 phosphorylation at serine 28 or 10, is coupled with the induction of immediate-early (IE) gene transcription...
  9. New L, Zhao M, Li Y, Bassett W, Feng Y, Ludwig S, et al. Cloning and characterization of RLPK, a novel RSK-related protein kinase. J Biol Chem. 1999;274:1026-32 pubmed
    ..The cDNA of this gene encodes an 802-amino acid protein (termed RLPK) with the highest homology (37% identity) to the two protein kinase families, p90(RSK) and p70(RSK)...
  10. Jamaluddin M, Tian B, Boldogh I, Garofalo R, Brasier A. Respiratory syncytial virus infection induces a reactive oxygen species-MSK1-phospho-Ser-276 RelA pathway required for cytokine expression. J Virol. 2009;83:10605-15 pubmed publisher
    ..RSV potently induced activation of cytoplasmic mitogen- and stress-related kinase 1 (MSK1) in an ROS-dependent manner...
  11. Luo X, Zhang H, Wei X, Shi M, Fan P, Xie W, et al. Aloin Suppresses Lipopolysaccharide-Induced Inflammatory Response and Apoptosis by Inhibiting the Activation of NF-κB. Molecules. 2018;23: pubmed publisher
    ..inhibits the phosphorylation and acetylation of the NF-κB p65 subunit by suppressing the upstream kinases p38 and Msk1, preventing LPS-induced p65 translocation to the nucleus...
  12. Singh K, Cassano M, Planet E, Sebastian S, Jang S, Sohi G, et al. A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation. Genes Dev. 2015;29:513-25 pubmed publisher
    ..Upon differentiation, MSK1-mediated phosphorylation of KAP1 releases the corepressors from the scaffold, unleashing transcriptional activation ..
  13. Chakraborty A, Diefenbacher M, Mylona A, Kassel O, Behrens A. The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling. Nat Commun. 2015;6:6782 pubmed publisher
    ..We found that MSK1 directly phosphorylates Trim7 in response to direct activation by the Ras-Raf-MEK-ERK pathway, and this ..
  14. Ohm A, Affandi T, Reyland M. EGF receptor and PKCδ kinase activate DNA damage-induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases. J Biol Chem. 2019;294:4488-4497 pubmed publisher
    ..We identified the nuclear kinase mitogen-sensitive kinase 1 (MSK1) as a downstream target of both early and late ERK activation...
  15. Armbruster N, Richardson J, Schreiner J, Klenk J, Günter M, Kretschmer D, et al. PSM Peptides of Staphylococcus aureus Activate the p38-CREB Pathway in Dendritic Cells, Thereby Modulating Cytokine Production and T Cell Priming. J Immunol. 2016;196:1284-92 pubmed publisher
    ..Furthermore, inhibition of p38 and downstream MSK1 prevented IL-10 production, which in turn reduced the capacity of DCs to activate regulatory T cells...
  16. Zhong Z, Feng S, Chen S, Chen Z, Chen X. Inhibition of MSK1 Promotes Inflammation and Apoptosis and Inhibits Functional Recovery After Spinal Cord Injury. J Mol Neurosci. 2019;: pubmed publisher
    ..Here, we aimed to elucidate this role using an in vivo animal model. In this study, we found that MSK1 is gradually decreased, starting 1 day after spinal cord injury and to its lowest level 3 days post-injury, after ..
  17. Schiller M, Bohm M, Dennler S, Ehrchen J, Mauviel A. Mitogen- and stress-activated protein kinase 1 is critical for interleukin-1-induced, CREB-mediated, c-fos gene expression in keratinocytes. Oncogene. 2006;25:4449-57 pubmed
    ..We also demonstrate that p38-dependent activation of mitogen- and stress-activated kinase 1 (MSK1), a CREB kinase, is a key step for c-fos gene activation by IL-1...
  18. Hou M, Wang W, Hu F, Zhang Y, Yang D, Liu Q. Phosphothreonine Lyase Promotes p65 Degradation in a Mitogen-Activated Protein Kinase/Mitogen- and Stress-Activated Protein Kinase 1-Dependent Manner. Infect Immun. 2019;87: pubmed publisher
    ..and ubiquitination of p65 by inhibiting the phosphorylation of mitogen- and stress-activated protein kinase-1 (MSK1) and by inhibiting the phosphorylation of extracellular signal-related kinase 1/2 (ERK1/2), p38α, and c-Jun N-..
  19. Gesser B, Johansen C, Rasmussen M, Funding A, Otkjaer K, Kjellerup R, et al. Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect. J Invest Dermatol. 2007;127:2129-37 pubmed
    ..A significant inhibition of both MSK1 and 2 activations was seen after preincubation with DMF and stimulation with IL-1beta, whereas MHF and FA had no ..
  20. Miyagaki Y, Kanemori Y, Baba T. Possible involvement of mitogen- and stress-activated protein kinase 1, MSK1, in metaphase-II arrest through phosphorylation of EMI2 in mouse oocytes. Dev Biol. 2011;359:73-81 pubmed publisher
    ..Here, we show the subcellular localization and possible role of mitogen- and stress-activated kinase 1, MSK1 known as another downstream kinase of the Mos-MAPK pathway, in the mouse oocytes...
  21. Moens U, Kostenko S. Structure and function of MK5/PRAK: the loner among the mitogen-activated protein kinase-activated protein kinases. Biol Chem. 2013;394:1115-32 pubmed publisher
    ..the ribosomal-S6-kinases RSK1-4, the MAPK-interacting kinases MNK1 and 2, the mitogen- and stress-activated kinases MSK1 and 2, the MAPK-activated protein kinases MK2 and 3, and the MAPK-activated protein kinase MK5 (also referred to as ..
  22. Harouz H, Rachez C, Meijer B, Marteyn B, Donnadieu F, Cammas F, et al. Shigella flexneri targets the HP1γ subcode through the phosphothreonine lyase OspF. EMBO J. 2014;33:2606-22 pubmed publisher
    ..This effector interacts with HP1γ and alters its phosphorylation at S83 by inactivating ERK and consequently MSK1, a downstream kinase...
  23. London N, Miller R, Krishnan S, Uchida K, Irwin J, Eidam O, et al. Covalent docking of large libraries for the discovery of chemical probes. Nat Chem Biol. 2014;10:1066-72 pubmed publisher
    ..protein nucleophiles, including the catalytic serine of AmpC β-lactamase and noncatalytic cysteines in RSK2, MSK1 and JAK3 kinases...
  24. Reyskens K, Arthur J. Emerging Roles of the Mitogen and Stress Activated Kinases MSK1 and MSK2. Front Cell Dev Biol. 2016;4:56 pubmed publisher
    ..In the CNS they are implicated in neuronal proliferation and synaptic plasticity. In this review we will focus on recent advances in understanding the roles of MSKs in the innate immune system and neuronal function. ..
  25. Bhat N, Park J, Zoghbi H, Arthur J, Zaret K. The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development. PLoS ONE. 2016;11:e0166703 pubmed publisher
    ..led us to investigate the temporal dynamics of ser-28 phosphorylated histone H3 (H3S28ph) and its upstream kinases, MSK1 and MSK2 (MSK1/2). H3S28ph and MSK1/2 were enriched at the key endocrine and acinar promoters in E12...
  26. Gawrzak S, Rinaldi L, Gregorio S, Arenas E, Salvador F, Urosevic J, et al. MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer. Nat Cell Biol. 2018;20:211-221 pubmed publisher
    ..Using an in vivo genome-wide short hairpin RNA screening, we identified the kinase MSK1 as an important regulator of metastatic dormancy in breast cancer...
  27. Li T, Liu Z, Jiang K, Ruan Q. Angiopoietin2 enhances doxorubin resistance in HepG2 cells by upregulating survivin and Ref-1 via MSK1 activation. Cancer Lett. 2013;337:276-84 pubmed publisher
    ..on anti-apoptotic genes was attenuated by either MSK inhibitor (H89) or by overexpression of a kinase-deficient MSK1. Activated MSK1 phosphorylated the CREB at Ser133 and phosho-CREB was recruited to Ref-1 promoter rapidly to ..
  28. Bomsztyk K, Flanagin S, Mar D, Mikula M, Johnson A, ZAGER R, et al. Synchronous recruitment of epigenetic modifiers to endotoxin synergistically activated Tnf-? gene in acute kidney injury. PLoS ONE. 2013;8:e70322 pubmed publisher
    ..In agreement with these observations, I/R but not LPS increased activity of cognate kinases (Erk1/2, Msk1/2 and Aurora A) at the Tnf-? locus...
  29. Xiong X, Zhu Y, Ge R, Liu L, Yuan W. Effect of Melatonin on the Extracellular-Regulated Kinase Signal Pathway Activation and Human Osteoblastic Cell Line hFOB 1.19 Proliferation. Int J Mol Sci. 2015;16:10337-53 pubmed publisher
    ..Furthermore, we also detected the phosphorylation of c-Raf, MEK1/2, p90RSK and MSK1, and all of them increased with 10 µM melatonin...
  30. Sahu G, Farley K, El Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, et al. Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR. Virology. 2015;483:185-202 pubmed publisher
    ..gene expression by activating both nuclear factor-kappa B (NF-ĸB) and mitogen- and stress-activated kinase 1 (MSK1)...
  31. Torres Perez J, Santha P, Varga A, Szucs P, Sousa Valente J, Gaál B, et al. Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain. Sci Rep. 2017;7:41221 pubmed publisher
    ..signal-regulated kinases 1 and 2, or blocking or deleting the mitogen- and stress-activated kinases 1 and 2 (MSK1/2), which phosphorylate S10 in H3, inhibit up-regulation in phosphorylated S10 in H3 (p-S10H3) as well as fos ..
  32. Zhang Y, Griffin K, Mondal N, Parvin J. Phosphorylation of histone H2A inhibits transcription on chromatin templates. J Biol Chem. 2004;279:21866-72 pubmed
    ..known to modify histones for effects on transcription, and we found that the mitogen- and stress-induced kinase, MSK1, inhibited RNA synthesis...
  33. Yarrow J, Totsukawa G, Charras G, Mitchison T. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol. 2005;12:385-95 pubmed
    ..We also profile the wound healing assay with a library of compounds with known bioactivities, revealing multiple pathways involved in the biology. ..
  34. Alcacer C, Charbonnier Beaupel F, Corvol J, Girault J, Hervé D. Mitogen- and stress-activated protein kinase 1 is required for specific signaling responses in dopamine-denervated mouse striatum, but is not necessary for L-DOPA-induced dyskinesia. Neurosci Lett. 2014;583:76-80 pubmed publisher
    ..ERK triggers nuclear responses, including phosphorylation of mitogen- and stress-activated protein kinase 1 (MSK1) and histone H3, and transcription of genes such as FosB...
  35. Nacht A, Pohl A, Zaurin R, Soronellas D, Quilez J, Sharma P, et al. Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters. EMBO J. 2016;35:1822-43 pubmed publisher
    ..recruited to transcriptionally repressed genes involved in cell proliferation along with the kinases ERK1/2 and MSK1. PR recruits BRG1 associated with the HP1?-LSD1 complex repressor complex, which is further anchored via binding of ..
  36. Kostenko S, Shiryaev A, Dumitriu G, Gerits N, Moens U. Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5. J Recept Signal Transduct Res. 2011;31:1-9 pubmed publisher
    ..ribosomal-S6-kinases (RSK1-4), the MAPK-interacting kinases (MNK1 and 2), the mitogen-and stress-activated kinases (MSK1 and 2), and the MAPKAPK (MK2, 3, and 5) subfamilies...
  37. Lin C, Shih C, Chen B. Thrombin-induced IL-8/CXCL8 release is mediated by CK2, MSK1, and NF-κB pathways in human lung epithelial cells. Eur J Pharmacol. 2015;767:135-43 pubmed publisher
    ..In this study, we further investigated the role of casein kinase 2 (CK2)/mitogen stress-activated protein kinase 1 (MSK1)-dependent p65 phosphorylation in thrombin-induced NF-κB activation and IL-8/CXCL8 release...
  38. Zhong Z, Zhou Y, Feng S, Huang Y, Chen X. [Effect of lentivirus-mediated small interfering RNA on mitogen- and stress-activated protein kinase 1 in spinal cord injury of rats]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018;32:941-950 pubmed publisher
    To investigate the expression changes and the repair effect of mitogen and stress- activated protein kinase 1 (MSK1) on spinal cord injury (SCI) in rats...
  39. Lemeer S, Gholami A, Wu Z, Kuster B. Quantitative proteome profiling of human myoma and myometrium tissue reveals kinase expression signatures with potential for therapeutic intervention. Proteomics. 2015;15:356-64 pubmed publisher
    ..Among these, nine kinases (ADCK4, CDK5, CSNK2B, DDR1, EPHB1, MAP2K2, PRKCB, PRKG1, and RPS6KA5) representing a number of cellular signaling pathways showed particularly strong discrimination potential...
  40. Simard F, Cloutier A, Ear T, Vardhan H, McDonald P. MEK-independent ERK activation in human neutrophils and its impact on functional responses. J Leukoc Biol. 2015;98:565-73 pubmed publisher
  41. Shah N, Tulapurkar M, Ramarathnam A, Brophy A, Martinez R, HOM K, et al. Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity. J Immunol. 2017;198:3296-3306 pubmed publisher
    ..61 SB203580-inhibited genes and 7 of 15 SB203580-inhibited transcription factors, but spared the anti-inflammatory MSK1/2 pathway...
  42. Song K, Lee W, Chung K, Koo J, Yang E, Choi J, et al. Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J Biol Chem. 2003;278:23243-50 pubmed
    ..Our results also indicate that the activation of mitogen- and stress-activated protein kinase 1 (MSK1) and cAMP-response element-binding protein and cAMP-response element signaling cascades via ERK and p38 MAP kinases ..
  43. Fujita Y, Kojima K, Ohhashi R, Hamada N, Nozawa Y, Kitamoto A, et al. MiR-148a attenuates paclitaxel resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression. J Biol Chem. 2010;285:19076-84 pubmed publisher
    ..Computer-aided algorithms predicted mitogen- and stress-activated protein kinase, MSK1, as a potential target of miR-148a. Indeed, miR-148a overexpression decreased expression of MSK1...
  44. Zhen J, Yuan J, Fu Y, Zhu R, Wang M, Chang H, et al. IL-22 promotes Fas expression in oligodendrocytes and inhibits FOXP3 expression in T cells by activating the NF-?B pathway in multiple sclerosis. Mol Immunol. 2017;82:84-93 pubmed publisher
    ..Tregs reversed the functions of IL-22. Taken together, these findings help to elucidate the mechanisms of IL-22 in MS development. ..
  45. Ro S, Hatton W, Koh S, Horowitz B. Molecular properties of small-conductance Ca2+-activated K+ channels expressed in murine colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2001;281:G964-73 pubmed
    ..Transient expression of mSK1, mSK2, and mSK3 in COS cells resulted in Ca2+-activated voltage-independent channels...
  46. Terazawa S, Nakajima H, Shingo M, Niwano T, Imokawa G. Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner. Exp Dermatol. 2012;21 Suppl 1:11-7 pubmed publisher
    ..Further, the MSK1 inhibitor H89 significantly down-regulated the increased secretion of PGE(2) and IL-8 in UVB-exposed human ..
  47. Ahn J, Lee J, Chin C, In S, Yang A, Park H, et al. MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression. Exp Mol Med. 2018;50:132 pubmed publisher
    Mitogen- and stress-activated kinase 1 (MSK1) is a chromatin kinase that facilitates activator-dependent transcription by altering chromatin structure through histone H3 phosphorylation...
  48. Kawaguchi M, Fujita J, Kokubu F, Huang S, Homma T, Matsukura S, et al. IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway. Am J Physiol Lung Cell Mol Physiol. 2009;296:L804-10 pubmed publisher
    ..Moreover, the effect of short interfering RNAs (siRNAs) targeting MSK1 and cAMP response element binding protein (CREB) on IL-17F-induced IL-11 expression was investigated...
  49. Lau P, Cheung P. Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing. Proc Natl Acad Sci U S A. 2011;108:2801-6 pubmed publisher
    ..regulatory functions of H3 phosphorylation, we developed an in vivo targeting approach and found that the H3 kinase MSK1 is a direct and potent transcriptional activator...
  50. Sabbattini P, Sjoberg M, Nikic S, Frangini A, Holmqvist P, Kunowska N, et al. An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation. Mol Biol Cell. 2014;25:904-15 pubmed publisher
    ..Deposition of H3K9me3/S10ph at silent genes is partially mediated by the mitogen- and stress-activated kinases (MSK1/2) and the Aurora B kinase...
  51. Cumming J, Debreczeni J, Edfeldt F, Evertsson E, Harrison M, Holdgate G, et al. Discovery and characterization of MAPK-activated protein kinase-2 prevention of activation inhibitors. J Med Chem. 2015;58:278-93 pubmed publisher
    ..inhibition of the activation by p38α of the downstream kinase MK2 in preference to an alternative substrate, MSK1. Enzyme kinetics, surface plasmon resonance (SPR), 2D protein NMR, and X-ray crystallography were used to determine ..
  52. Sharma A, Khan S, Sharda A, Reddy D, Gupta S. MKP1 phosphatase mediates G1-specific dephosphorylation of H3Serine10P in response to DNA damage. Mutat Res. 2015;778:71-9 pubmed publisher
    ..of H3S10P in response to IR-induced DNA damage is mediated by opposing activities of phosphatase, MKP1 and kinase, MSK1 of the MAP kinase pathway...
  53. Lee Sherick A, Eisenman K, Sather S, McGranahan A, Armistead P, McGary C, et al. Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia. Oncogene. 2013;32:5359-68 pubmed publisher
    ..observed activation of prosurvival and proliferative signaling pathways, including phosphorylation of ERK1/2, p38, MSK1, CREB, ATF1, AKT and STAT6...
  54. Bonito Oliva A, Södersten E, Spigolon G, Hu X, Hellysaz A, Falconi A, et al. Differential regulation of the phosphorylation of Trimethyl-lysine27 histone H3 at serine 28 in distinct populations of striatal projection neurons. Neuropharmacology. 2016;107:89-99 pubmed publisher
    ..In contrast, knockout of the mitogen- and stress activated kinase 1 (MSK1), which is implicated in the phosphorylation of histone H3, decreases the effect of amphetamine, but not that of ..
  55. Choi Y, Horning P, Aten S, Karelina K, Alzate Correa D, Arthur J, et al. Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus. ASN Neuro. 2017;9:1759091417726607 pubmed publisher
    ..signal-regulated kinase/MAPK pathway and the p38 MAPK pathway is Mitogen- and Stress-activated protein Kinase 1 (MSK1)...
  56. Iglesias Gato D, Wikström P, Tyanova S, Lavallee C, Thysell E, Carlsson J, et al. The Proteome of Primary Prostate Cancer. Eur Urol. 2016;69:942-52 pubmed publisher
    ..protein complex, subunit alpha (COPA, vesicle secretion), and mitogen- and stress-activated protein kinase 1 and 2 (MSK1/2, protein kinase) regulate the proliferation of PCa cells...
  57. Alghamdi T, Batchu S, Hadden M, Yerra V, Liu Y, Bowskill B, et al. Histone H3 Serine 10 Phosphorylation Facilitates Endothelial Activation in Diabetic Kidney Disease. Diabetes. 2018;67:2668-2681 pubmed publisher
    ..a pathway regulated by p38 mitogen-activated protein kinase, mitogen- and stress-activated protein kinases 1/2 (MSK1/2), and phosphorylation of H3Ser10, whereas MSK1/2 inhibition decreased H3Ser10 phosphorylation at the VCAM1 ..
  58. Södersten E, Feyder M, Lerdrup M, Gomes A, Kryh H, Spigolon G, et al. Dopamine signaling leads to loss of Polycomb repression and aberrant gene activation in experimental parkinsonism. PLoS Genet. 2014;10:e1004574 pubmed publisher
    ..histone mark specifically occurs in medium spiny neurons expressing dopamine D1 receptors and is dependent on Msk1 kinase activity and DARPP-32-mediated inhibition of protein phosphatase-1...
  59. Arthur J, Cohen P. MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells. FEBS Lett. 2000;482:44-8 pubmed
    Mouse embryonic stem (ES) cells homozygous for disruption of the MSK1 gene had no detectable MSK1 activity...
  60. Smerdová L, Šmerdová J, Kabátková M, Kohoutek J, Blažek D, Machala M, et al. Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway. Carcinogenesis. 2014;35:2534-43 pubmed publisher
    ..activation of the p38 mitogen-activated protein kinase (p38) and mitogen- and stress-activated protein kinase 1 (MSK1)...
  61. Dumka D, Puri P, Carayol N, Lumby C, Balachandran H, Schuster K, et al. Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib. Leuk Lymphoma. 2009;50:2017-29 pubmed publisher
    ..p38 Map kinase (MAPK) pathway is activated leading to increased upregulation of mixed lineage kinase 3, MKK3/6, MSK1, and Mapkapk2, upon treatment of BCR/ABL expressing cells with dasatinib, including cells expressing various ..
  62. Queisser N, Schupp N, Schwarz E, Hartmann C, MacKenzie G, Oteiza P. Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via redox-regulated mechanisms. Mol Carcinog. 2017;56:1868-1883 pubmed publisher
    ..ERK1/2 activation led to an increased phosphorylation of MSK1, p90RSK, and STAT3...
  63. Fu X, Fan X, Hu J, Zou H, Chen Z, Liu Q, et al. Overexpression of MSK1 is associated with tumor aggressiveness and poor prognosis in colorectal cancer. Dig Liver Dis. 2017;49:683-691 pubmed publisher
    Mitogen- and stress-activated protein kinase 1 (MSK1) has recently been implicated in cell proliferation and neoplastic transformation. However, the involvement of MSK1 in colorectal cancer (CRC) has not been addressed...
  64. Karelina K, Liu Y, Alzate Correa D, Wheaton K, Hoyt K, Arthur J, et al. Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis. Neuroscience. 2015;285:292-302 pubmed publisher
    ..Here, we investigated the role of mitogen and stress-activated protein kinases (MSK1/2) in the regulation of progenitor cell proliferation and neurogenesis after cerebral ischemia...
  65. Pu X, Storr S, Ahmad N, Rakha E, Green A, Ellis I, et al. High nuclear MSK1 is associated with longer survival in breast cancer patients. J Cancer Res Clin Oncol. 2018;144:509-517 pubmed publisher
    ..b>MSK1 and MSK2 are both nuclear serine/threonine protein kinases, with MSK1 being suggested to potentially play a role in ..
  66. Lee C, Kim T, Lee J, Oh S, Yoo J, Kwon H, et al. Extracellular signal-regulated kinase 1/2 signaling pathway is required for endometrial decidualization in mice and human. PLoS ONE. 2013;8:e75282 pubmed publisher
    ..decidualization marker genes, IGFBP1 and PRL as well as inhibited the induction of known ERK1/2 target genes; FOS, MSK1, STAT1, and STAT3...
  67. Kurita H, Schnekenburger M, Ovesen J, Xia Y, Puga A. The Ah receptor recruits IKK? to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation. Toxicol Sci. 2014;139:121-32 pubmed publisher
    ..protein kinases, we identified three kinases, I?B kinase ? (IKK?), mitogen and stress activated protein kinase 1 (MSK1), and mitogen and stress activated protein kinase 2 (MSK2), whose binding to the Cyp1a1 enhancer was significantly ..
  68. Choi M, Yoo N, An C, Lee S. Frameshift mutations in mammalian target of rapamycin pathway genes and their regional heterogeneity in sporadic colorectal cancers. Hum Pathol. 2015;46:753-60 pubmed publisher
    ..Through public database searching, we found that PIK3CB, insulin receptor substrate 1/2 (IRS1), RPS6, EIF4B, RPS6KA5, and PRKAA2 that were known as mTOR-related genes possessed mononucleotide repeats in DNA coding sequences that ..
  69. Culerrier R, Carraz M, Mann C, Djabali M. MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence. Mol Biol Cell. 2016;27:2726-34 pubmed publisher
    ..Here we show that the mitogen- and stress-activated kinase (MSK1) is up-regulated after RAF1 oncogenic stress and that the phosphorylated (activated) form of MSK1 is significantly ..
  70. Huante Mendoza A, Silva García O, Oviedo Boyso J, Hancock R, Baizabal Aguirre V. Peptide IDR-1002 Inhibits NF-?B Nuclear Translocation by Inhibition of I?B? Degradation and Activates p38/ERK1/2-MSK1-Dependent CREB Phosphorylation in Macrophages Stimulated with Lipopolysaccharide. Front Immunol. 2016;7:533 pubmed
    ..IDR-1002 also increased CREB phosphorylation at Ser133 via activation of the p38/ERK1/2-MSK1 signaling pathways without detectable expression of the cytokines IL-4, IL-10, and IL-13 involved is suppressing ..
  71. Gesser B, Rasmussen M, Raaby L, Rosada C, Johansen C, Kjellerup R, et al. Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression. Inflamm Res. 2011;60:643-53 pubmed publisher
    ..We studied the effect of DMF on the MIF-induced activation of the mitogen- and stress-activated kinase 1 (MSK1) and p90 kDa ribosomal S6 kinase (RSK1) signaling pathways which regulate the proliferation of human keratinocytes ..
  72. Aliabadi H, Maranchuk R, Kucharski C, Mahdipoor P, Hugh J, Uludag H. Effective response of doxorubicin-sensitive and -resistant breast cancer cells to combinational siRNA therapy. J Control Release. 2013;172:219-228 pubmed publisher
    ..Promising kinase siRNAs were co-delivered with anti-apoptotic Mcl-1 siRNA and Ribosomal Protein S6 Kinase (RPS6KA5) was found the most promising candidate for simultaneous silencing with Mcl-1...
  73. Wagley Y, Law P, Wei L, Loh H. Epigenetic Activation of μ-Opioid Receptor Gene via Increased Expression and Function of Mitogen- and Stress-Activated Protein Kinase 1. Mol Pharmacol. 2017;91:357-372 pubmed publisher
    ..involving mitogen-activated protein kinase (MAPK) activation and mitogen- and stress-activated protein kinase 1 (MSK1)-ranges of intracellular signaling pathways similar to those activated by opioid agonists...
  74. Wijenayake S, Luu B, Zhang J, Tessier S, Quintero Galvis J, Gaitán Espitia J, et al. Strategies of biochemical adaptation for hibernation in a South American marsupial Dromiciops gliroides: 1. Mitogen-activated protein kinases and the cell stress response. Comp Biochem Physiol B Biochem Mol Biol. 2018;224:12-18 pubmed publisher
    ..targets evaluated included key protein kinases in their activated phosphorylated forms (p-ERK/MAPK 1/2, p-MEK1, p-MSK1, p-p38, p-JNK) and related target proteins (p-CREB 2, p-ATF2, p-c-Jun and p-p53)...
  75. Niu J, Xue A, Chi Y, Xue J, Wang W, Zhao Z, et al. Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer. Oncogene. 2016;35:1302-1313 pubmed publisher
    ..STAT3 not only directly bound to MIR181A1 promoter to drive transcription but also facilitated the recruitment of MSK1 to the same region where MSK1 promoted a local active chromatin state by phosphorylating histone H3...
  76. Khan D, Healy S, He S, Lichtensztejn D, Klewes L, Sharma K, et al. Mitogen-induced distinct epialleles are phosphorylated at either H3S10 or H3S28, depending on H3K27 acetylation. Mol Biol Cell. 2017;28:817-824 pubmed publisher
    Stimulation of the MAPK pathway results in mitogen- and stress-activated protein kinase 1/2 (MSK1/2)-catalyzed phosphorylation of histone H3 at serine 10 or 28 and expression of immediate-early (IE) genes...
  77. Sinha P, Tesfaye D, Rings F, Hossien M, Hoelker M, Held E, et al. MicroRNA-130b is involved in bovine granulosa and cumulus cells function, oocyte maturation and blastocyst formation. J Ovarian Res. 2017;10:37 pubmed publisher
    ..The luciferase assay showed that SMAD5 and MSK1 genes were identified as the direct targets of miR-130b...
  78. Lang F, Bissinger R, Abed M, Artunc F. Eryptosis - the Neglected Cause of Anemia in End Stage Renal Disease. Kidney Blood Press Res. 2017;42:749-760 pubmed publisher
    ..AMP-activated kinase, p21-activated kinase 2, cGMP-dependent protein kinase, mitogen- and stress-activated kinase MSK1/2, and some illdefined tyrosine kinases...
  79. Lim C, Cao X. Serine phosphorylation and negative regulation of Stat3 by JNK. J Biol Chem. 1999;274:31055-61 pubmed
    ..The inhibitory effect was not observed for Stat1. Our results suggest that Stat3 is a target of JNK that may regulate Stat3 activity via both Ser-727 phosphorylation-dependent and -independent mechanisms. ..
  80. Tanoue T, Maeda R, Adachi M, Nishida E. Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions. EMBO J. 2001;20:466-79 pubmed
  81. Feyder M, Södersten E, Santini E, Vialou V, LaPlant Q, Watts E, et al. A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ∆FosB Expression. Biol Psychiatry. 2016;79:362-71 pubmed publisher
    ..We examined the involvement of mitogen- and stress-activated kinase 1 (MSK1), a downstream target of extracellular signal-regulated kinases 1 and 2, and an important regulator of ..
  82. Cheng M, Zhang Y, Cao C, Zhang W, Zhang Y, Shen Y. Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock. PLoS Biol. 2014;12:e1002026 pubmed publisher
    ..Here, we demonstrated that mitogen- and stress-activated protein kinase 1 (MSK1) specifically phosphorylates KDM3A at Ser264 (p-KDM3A), which is enriched in the regulatory regions of gene loci in ..
  83. Wiersma M, Bussiere M, Halsall J, Turan N, Slany R, Turner B, et al. Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes. Epigenetics Chromatin. 2016;9:52 pubmed
    ..KMT2A/MLL1 (both native and FLAG-tagged) and Msk1 (RPS6KA5) co-immunoprecipitated in various cell types...
  84. Toska K, Kleppe R, Armstrong C, Morrice N, Cohen P, Haavik J. Regulation of tyrosine hydroxylase by stress-activated protein kinases. J Neurochem. 2002;83:775-83 pubmed
    ..human tyrosine hydroxylase (hTH1) was found to be phosphorylated by mitogen and stress-activated protein kinase 1 (MSK1) at Ser40 and by p38 regulated/activated kinase (PRAK) on Ser19...
  85. Bouzas S, Marini M, Torres Zelada E, Buzzi A, Morales Vicente D, Strobl Mazzulla P. Epigenetic activation of Sox2 gene in the developing vertebrate neural plate. Mol Biol Cell. 2016;27:1921-7 pubmed publisher
    ..By using loss and gain of function, we find that Sox2 expression requires the activity of JmjD2A and the Msk1 kinase, which can respectively demethylate the repressive H3K9me3 mark and phosphorylate the activating H3S10 (..
  86. Gonzalez A, Hoffman J, Townsend J, Jajtner A, Boone C, Beyer K, et al. Intramuscular MAPK signaling following high volume and high intensity resistance exercise protocols in trained men. Eur J Appl Physiol. 2016;116:1663-70 pubmed publisher
    ..No significant differences over time were noted for phosphorylation of MEK1, ERK1/2, p38, MSK1, ATF2, p53, or c-Jun (p > 0.05)...
  87. Yu L, Ham K, Gao X, Castro L, Yan Y, Kissling G, et al. Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling. Cell Commun Signal. 2016;14:18 pubmed publisher
    ..evaluated if MAPKp44/42 could activate downstream effectors such as mitogen- and stress-activated protein kinase 1 (MSK1), which could then epigenetically modify histone H3 by phosphorylation following a low dose (1 ?g/ml) of genistein...
  88. McGuire V, Rosner D, Ananieva O, Ross E, Elcombe S, Naqvi S, et al. Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways. Mol Cell Biol. 2017;37: pubmed publisher
    ..here that macrophage expression of IFN-β is negatively regulated by mitogen- and stress-activated kinases 1 and 2 (MSK1/2). Lipopolysaccharide (LPS)-induced expression of IFN-β was elevated in both MSK1/2 knockout mice and macrophages...
  89. Haj M, Wijeweera A, Rudnizky S, Taunton J, Pnueli L, Melamed P. Mitogen- and stress-activated protein kinase 1 is required for gonadotropin-releasing hormone-mediated activation of gonadotropin α-subunit expression. J Biol Chem. 2017;292:20720-20731 pubmed publisher
    ..increased H3S28p and H3K27ac levels and also those of activated mitogen- and stress-activated protein kinase 1 (MSK1)...
  90. Dolled Filhart M, Camp R, Kowalski D, Smith B, Rimm D. Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis. Clin Cancer Res. 2003;9:594-600 pubmed
  91. Niwano T, Terazawa S, Nakajima H, Imokawa G. The stem cell factor-stimulated melanogenesis in human melanocytes can be abrogated by interrupting the phosphorylation of MSK1: evidence for involvement of the p38/MSK1/CREB/MITF axis. Arch Dermatol Res. 2018;310:187-196 pubmed publisher
    ..We show for the first time that treatment of NHMs with SCF activates the p38/mitogen and stress-activated kinase (MSK1) axis in a c-KIT dependent fashion...
  92. Lizcano J, Morrice N, Cohen P. Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem J. 2000;349:547-57 pubmed