RPS6KA3

Summary

Gene Symbol: RPS6KA3
Description: ribosomal protein S6 kinase A3
Alias: CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2, ribosomal protein S6 kinase alpha-3, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, RSK-2, S6K-alpha-3, insulin-stimulated protein kinase 1, p90-RSK 3, ribosomal S6 kinase 2, ribosomal protein S6 kinase, 90kDa, polypeptide 3
Species: human
Products:     RPS6KA3

Top Publications

  1. Trivier E, De Cesare D, Jacquot S, Pannetier S, Zackai E, Young I, et al. Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Nature. 1996;384:567-70 pubmed
    ..Genetic linkage analysis mapped the CLS locus to an interval of 2-3 megabases at Xp22.2. The gene coding for Rsk-2, a member of the growth-factor-regulated protein kinases, maps within the candidate interval, and was tested as a ..
  2. Sassone Corsi P, Mizzen C, Cheung P, Crosio C, Monaco L, Jacquot S, et al. Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science. 1999;285:886-91 pubmed
    ..RSK-2 mutations in humans are linked to Coffin-Lowry syndrome (CLS)...
  3. Jensen C, Buch M, Krag T, Hemmings B, Gammeltoft S, Frodin M. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. J Biol Chem. 1999;274:27168-76 pubmed
    90-kDa ribosomal S6 kinase-2 (RSK2) belongs to a family of growth factor-activated serine/threonine kinases composed of two kinase domains connected by a regulatory linker region...
  4. Frodin M, Jensen C, Merienne K, Gammeltoft S. A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1. EMBO J. 2000;19:2924-34 pubmed
    The 90 kDa ribosomal S6 kinase-2 (RSK2) is a growth factor-stimulated protein kinase with two kinase domains...
  5. Xing J, Ginty D, Greenberg M. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science. 1996;273:959-63 pubmed
    ..and biochemical characterization of CREB kinase revealed that it is identical to a member of the pp90(RSK) family, RSK2. RSK2 was shown to mediate growth factor induction of CREB serine-133 phosphorylation both in vitro and in vivo...
  6. Doehn U, Hauge C, Frank S, Jensen C, Duda K, Nielsen J, et al. RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells. Mol Cell. 2009;35:511-22 pubmed publisher
    ..Many mechanisms by which ERK exerts this control remain elusive. We demonstrate that the ERK-activated kinase RSK is necessary to induce mesenchymal motility and invasive capacities in nontransformed epithelial and carcinoma ..
  7. Soloaga A, Thomson S, Wiggin G, Rampersaud N, Dyson M, Hazzalin C, et al. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J. 2003;22:2788-97 pubmed
    ..One study, based on Coffin- Lowry cells defective in RSK2, reported that RSK2 was the histone H3 kinase, while a second study, based on the efficiency of RSKs and MSKs as in ..
  8. Yang X, Matsuda K, Bialek P, Jacquot S, Masuoka H, Schinke T, et al. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 2004;117:387-98 pubmed
    ..The gene mutated in CLS, RSK2, encodes a growth factor-regulated kinase...
  9. Clark D, Errington T, Smith J, Frierson H, Weber M, Lannigan D. The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation. Cancer Res. 2005;65:3108-16 pubmed
    ..Increasing RSK isoform 2 (RSK2) levels in the human prostate cancer line, LNCaP, enhanced prostate-specific antigen (PSA) expression, an important ..

More Information

Publications103 found, 100 shown here

  1. Smith J, Poteet Smith C, Malarkey K, Sturgill T. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. J Biol Chem. 1999;274:2893-8 pubmed
    ..GST)-fusion proteins containing the carboxyl-terminal tails of three p90 ribosomal S6 kinase (RSK) isozymes (RSK1, RSK2, and RSK3) interacted with extracellular signal-regulated kinase (ERK) but not c-Jun-NH2-kinase (JNK) or p38 ..
  2. Guimiot F, Delezoide A, Hanauer A, Simonneau M. Expression of the RSK2 gene during early human development. Gene Expr Patterns. 2004;4:111-4 pubmed
    The 90 kDa ribosomal S6 serine/threonine kinase 2 gene (RSK2, U08316) has been recently identified as a disease-causing gene in an X-linked disorder, the Coffin-Lowry Syndrome (MIM 303600) characterized by severe mental retardation, ..
  3. Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, et al. p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J Clin Invest. 2010;120:1165-77 pubmed publisher
    ..Here, we report that p90 ribosomal S6 kinase 2 (RSK2) promotes human HNSCC cell invasion and metastasis...
  4. Zhu F, Zykova T, Peng C, Zhang J, Cho Y, Zheng D, et al. Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation. Cancer Res. 2011;71:393-403 pubmed publisher
    ..Herein, we found that ribosomal S6 kinase 2 (RSK2) directly phosphorylates histone H2AX at Ser139 and also at a newly discovered site, Ser16...
  5. Joel P, Smith J, Sturgill T, Fisher T, Blenis J, Lannigan D. pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Mol Cell Biol. 1998;18:1978-84 pubmed
    ..Taken together, our results strongly suggest that pp90rsk1 phosphorylates Ser-167 of the human ER in vivo and that Ser-167 aids in regulating the transcriptional activity of AF-1 in the ER. ..
  6. Jacquot S, Merienne K, De Cesare D, Pannetier S, Mandel J, Sassone Corsi P, et al. Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations. Am J Hum Genet. 1998;63:1631-40 pubmed
    ..By using a positional cloning approach, we have recently shown that mutations in the gene coding for the RSK2 serine-threonine protein kinase are responsible for this syndrome...
  7. Zeniou M, Ding T, Trivier E, Hanauer A. Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning. Hum Mol Genet. 2002;11:2929-40 pubmed
    ..The gene implicated in CLS encodes RSK2, a serine/threonine kinase acting in the Ras/MAPK signalling pathway...
  8. Kang S, Dong S, Guo A, Ruan H, Lonial S, Khoury H, et al. Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529. J Biol Chem. 2008;283:4652-7 pubmed
    The Ser/Thr kinase ribosomal S6 kinase 2 (RSK2) has been demonstrated to phosphorylate transcription factor CREB (cyclic AMP-responsive-binding protein) and histone H3 in response to mitogenic stimulation by epidermal growth factor (EGF)...
  9. Eisinger Mathason T, Andrade J, Groehler A, Clark D, Muratore Schroeder T, Pasic L, et al. Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival. Mol Cell. 2008;31:722-36 pubmed publisher
    ..We report an unanticipated link between stress granules and the serine/threonine kinase RSK2. In stressed breast cells, endogenous RSK2 colocalizes in granules with TIA-1 and poly(A)-binding protein 1, and ..
  10. Anjum R, Blenis J. The RSK family of kinases: emerging roles in cellular signalling. Nat Rev Mol Cell Biol. 2008;9:747-58 pubmed publisher
    The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases that regulate diverse cellular processes, such as cell growth, cell motility, cell survival and cell proliferation...
  11. Merienne K, Pannetier S, Harel Bellan A, Sassone Corsi P. Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities. Mol Cell Biol. 2001;21:7089-96 pubmed
    The protein kinase ribosomal S6 kinase 2 (RSK2) has been implicated in phosphorylation of transcription factor CREB and histone H3 in response to mitogenic stimulation by epidermal growth factor...
  12. Roux P, Richards S, Blenis J. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Mol Cell Biol. 2003;23:4796-804 pubmed
    ..Analysis of different RSK isoforms revealed that RSK1 and RSK2 readily dissociate from ERK1/2 following mitogen stimulation but that RSK3 remains associated with active ERK1/2...
  13. Kesler S, Simensen R, Voeller K, Abidi F, Stevenson R, Schwartz C, et al. Altered neurodevelopment associated with mutations of RSK2: a morphometric MRI study of Coffin-Lowry syndrome. Neurogenetics. 2007;8:143-7 pubmed
    Coffin-Lowry syndrome (CLS) is a rare form of X-linked mental retardation caused by mutations of the RSK2 gene, associated with cognitive impairment and skeletal malformations...
  14. Zhang Y, Cho Y, Petersen B, Bode A, Zhu F, Dong Z. Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3. J Biol Chem. 2003;278:12650-9 pubmed
    ..Furthermore, we provide evidence that RSK2-deficient cells were defective for UV-induced Ser(727) phosphorylation of STAT3, and the defect was restored after ..
  15. Vaidyanathan H, Ramos J. RSK2 activity is regulated by its interaction with PEA-15. J Biol Chem. 2003;278:32367-72 pubmed publisher
    ..One target substrate of ERK involved in regulating transcription is the p90 ribosomal S6 kinase (RSK) isozyme, RSK2. Here we demonstrate that a small death effector domain-containing protein called PEA-15 binds RSK2...
  16. Cohen M, Zhang C, Shokat K, Taunton J. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science. 2005;308:1318-21 pubmed
    ..inhibitor, designed to exploit both selectivity filters, potently and selectively inactivated RSK1 and RSK2 in mammalian cells...
  17. Poomakkoth N, Issa A, Abdulrahman N, Abdelaziz S, Mraiche F. p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer. J Transl Med. 2016;14:14 pubmed publisher
    ..p90 ribosomal S6 kinase (RSK), a serine threonine kinase that lies downstream of the Ras-MAPK (mitogen activated protein kinase) cascade, has ..
  18. Lin L, Jin Y, Hu K. Tissue-type plasminogen activator (tPA) promotes M1 macrophage survival through p90 ribosomal S6 kinase (RSK) and p38 mitogen-activated protein kinase (MAPK) pathway. J Biol Chem. 2015;290:7910-7 pubmed publisher
    ..tPA induced the phosphorylation of Erk1/2, p90 ribosomal S6 kinase (RSK), and p38 in a temporal order...
  19. Jung E, Cho J, Park D, Kim M, Park B, Lee S, et al. Vegetable peptones increase production of type I collagen in human fibroblasts by inducing the RSK-CCAAT/enhancer binding protein-β phosphorylation pathway. Nutr Res. 2015;35:127-35 pubmed publisher
  20. Cho Y. Molecular Targeting of ERKs/RSK2 Signaling in Cancers. Curr Pharm Des. 2017;23:4247-4258 pubmed publisher
    Accumulating studies have provided concrete evidence that p90 ribosomal S6 kinase 2 (RSK2) is a key signaling molecule involved in cell proliferation, transformation, and cancer development...
  21. Kuppusamy P, Nagalingam A, Muniraj N, Saxena N, Sharma D. Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice. Sci Rep. 2017;7:17943 pubmed publisher
    ..Further analyses revealed a key role of ERK leading to increased phosphorylation of p90-ribosomal S6 kinase (RSK) and a concomitant activation of ETS-like transcription factor-1(ELK1) and Death Receptor protein-5 (DR5) in HCC...
  22. Gillen J, Li W, Liang Q, Avey D, Wu J, Wu F, et al. A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses. J Virol. 2015;89:4918-31 pubmed publisher
    ..In addition to the previously identified extracellular regulated kinase (ERK) and p90 ribosomal S6 kinase (RSK) proteins, we found several other copurified proteins, including prominent ones of ∼38 kDa and ∼130 kDa...
  23. Im J, Kim B, Lee J, Park S, Ban H, Jung K, et al. DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells. Oncogene. 2018;37:1251-1262 pubmed publisher
    ..This effect was abolished by RSK2 overexpression...
  24. Liu F, Iqbal K, Grundke Iqbal I, Gong C. Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. FEBS Lett. 2002;530:209-14 pubmed
    ..These data suggest that aberrant glycosylation of tau in AD might be involved in neurofibrillary degeneration by promoting abnormal hyperphosphorylation by cdk5 and GSK-3beta. ..
  25. Yamaguchi T, Kinugasa Y, Shiomi A, Tomioka H, Kagawa H, Yamakawa Y. Robotic-assisted vs. conventional laparoscopic surgery for rectal cancer: short-term outcomes at a single center. Surg Today. 2016;46:957-62 pubmed publisher
    ..of RALS for rectal cancer by comparing its short-term outcomes with those of conventional laparoscopic surgery (CLS). Between April, 2010 and April, 2015, a total of 974 patients underwent proctectomy for rectal cancer...
  26. Gifford P, Gifford K. The Future of Myopia Control Contact Lenses. Optom Vis Sci. 2016;93:336-43 pubmed publisher
    ..Although contact lenses (CLs) are prescribed primarily for refractive correction, there is burgeoning use of particular modalities for slowing ..
  27. Hafeez S, Urooj M, Saleem S, Gillani Z, Shaheen S, Qazi M, et al. BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. PLoS ONE. 2016;11:e0145780 pubmed publisher
    ..Evidence for inhibition of ERK1/2 by deguelin and escape of BAD phosphorylation at serine 112 through ERK/RSK pathway has been further fortified by obtaining similar results by silencing ERK 1/2 each with specific siRNAs...
  28. Peyta L, Jarnouen K, Pinault M, Guimaraes C, Pais de Barros J, Chevalier S, et al. Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells. Biochim Biophys Acta. 2016;1857:443-53 pubmed publisher
    ..shCLS cells exhibited a 55% reduction in CLS gene and a 40% decrease in protein expression resulting in a 45% lower content in CL compared to control (shCTL) ..
  29. Islam M, Islam M, Samsuzzaman M, Faruque M, Misran N, Mansor M. A Miniaturized Antenna with Negative Index Metamaterial Based on Modified SRR and CLS Unit Cell for UWB Microwave Imaging Applications. Materials (Basel). 2015;8:392-407 pubmed publisher
    ..employing a negative index metamaterial with modified split-ring resonator (SRR) and capacitance-loaded strip (CLS) unit cells is presented for Ultra wideband (UWB) microwave imaging applications...
  30. Tejada M, Martinez Bouzas C, Garcia Ribes A, Larrucea S, Acquadro F, Cigudosa J, et al. A child with mild X-linked intellectual disability and a microduplication at Xp22.12 including RPS6KA3. Pediatrics. 2011;128:e1029-33 pubmed publisher
    ..This 1.05-megabase duplication encompasses 7 genes, RPS6KA3 being the only of these genes known to be related to ID...
  31. Zhao H, Martin T, Davies E, Ruge F, Yu H, Zhang Y, et al. The Clinical Implications of RSK1-3 in Human Breast Cancer. Anticancer Res. 2016;36:1267-74 pubmed
    ..mRNA expression of RSK2 was negatively correlated with grade, TNM staging, and survival rate...
  32. Ravichandran D, Praveenkumar P, Balaguru Rayappan J, Amirtharajan R. Chaos based crossover and mutation for securing DICOM image. Comput Biol Med. 2016;72:170-84 pubmed publisher
    ..decomposed images are then mutated by XOR operation with quantized chaotic sequences from Combined Logistic-Sine (CLS) system...
  33. Zhou F, Li M, Wei Y, Lin K, Lu Y, Shen J, et al. Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells. Oncotarget. 2016;7:84093-84117 pubmed publisher
    ..Mechanistically, downregulation of HERV-K blocked expression of tumor-associated genes that included Ras, p-RSK, and p-ERK. The major upstream regulators influenced by HERV-K knockdown were p53, TGF- β1, and MYC...
  34. Kitamata Wong B, Yuen T, Li W, Svitova T, Zhou Y, Lin M. Effects of Lens-Care Solutions on Hydrogel Lens Performance. Optom Vis Sci. 2017;94:1036-1046 pubmed publisher
    ..In vitro study was also performed to assess the effect of MPSs on CL surface properties. Acuvue 2 CLs were soaked in control solution, Clear Care (CC), or test solutions: PureMoist, Biotrue, RevitaLens (RL), or saline ..
  35. Terazawa S, Imokawa G. Signaling Cascades Activated by UVB in Human Melanocytes Lead to the Increased Expression of Melanocyte-receptors, Endothelin B Receptor and c-KIT¶. Photochem Photobiol. 2017;: pubmed publisher
    ..of MITF that leads to the up-regulation of melanocyte-specific proteins in UVB-exposed NHMs is mediated via activation of the p38/MSK1/CREB axis but not the ERK/RSK/CREB axis. This article is protected by copyright. All rights reserved.
  36. Gogl G, Biri Kovács B, Póti Á, Vadászi H, Szeder B, Bodor A, et al. Dynamic control of RSK complexes by phosphoswitch-based regulation. FEBS J. 2017;: pubmed publisher
    ..The CTT also contains a classical PDZ domain-binding motif which binds RSK substrates (e.g. MAGI-1)...
  37. Martínez Sernández V, Perteguer M, Hernandez Gonzalez A, Mezo M, González Warleta M, Orbegozo Medina R, et al. Comparison of recombinant cathepsins L1, L2, and L5 as ELISA targets for serodiagnosis of bovine and ovine fascioliasis. Parasitol Res. 2018;117:1521-1534 pubmed publisher
    ..However, although adult flukes produce three different clades of CLs (FhCL1, FhCL2, and FhCL5), to our knowledge, the diagnostic value of recombinant FhCL2 and FhCL5 has not yet been ..
  38. Willard F, Crouch M. MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit. Cell Signal. 2001;13:653-64 pubmed
    ..of the MAP kinase pathway including regulators (MEK1/2), substrates (90-kDa ribosomal S6 kinases (RSKs): RSK1, RSK2 and RSK3), and ERK itself...
  39. Chrestensen C, Sturgill T. Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase. J Biol Chem. 2002;277:27733-41 pubmed
    ..GST-RSK2-(aa373-740) was phosphorylated in the P-loop (Thr(577)) by MAPK, accompanied by increased phosphorylation on the ..
  40. Karijolich J, Zhao Y, Peterson B, Zhou Q, Glaunsinger B. Kaposi's sarcoma-associated herpesvirus ORF45 mediates transcriptional activation of the HIV-1 long terminal repeat via RSK2. J Virol. 2014;88:7024-35 pubmed publisher
    ..Of the three widely expressed RSK isoforms, RSK2 appears to be selectively involved in LTR stimulation by both KSHV ORF45 and HIV-1 Tat...
  41. Zhou Y, Yamada N, Tanaka T, Hori T, Yokoyama S, Hayakawa Y, et al. Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2. Nat Commun. 2015;6:7679 pubmed publisher
    ..We show that inflammatory cytokines promote RSK-, not Akt-, dependent phosphorylation of EphA2 at Ser-897...
  42. Zullo A, Dore D, DAIELLO L, Baier R, Gutman R, Gifford D, et al. National Trends in Treatment Initiation for Nursing Home Residents With Diabetes Mellitus, 2008 to 2010. J Am Med Dir Assoc. 2016;17:602-8 pubmed publisher
    ..4% of initiations in 2008 to 11.7% in 2010, an average decrease of 1% per quarter (95% CLs -1.5 to -0.5). Thiazolidinedione initiation decreased from 4.7% to 1.9%, an average decrease of 0...
  43. Hamaoka Y, Negishi M, Katoh H. EphA2 is a key effector of the MEK/ERK/RSK pathway regulating glioblastoma cell proliferation. Cell Signal. 2016;28:937-45 pubmed publisher
    ..The RSK inhibitor or RSK2-targeted shRNA also suppressed EGF-induced cell proliferation...
  44. Baumann C, Ullrich A, Torka R. GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance. Mol Oncol. 2017;11:1430-1447 pubmed publisher
    ..Self-sustaining cells are characterized by excessive GAS6 secretion and TAM-PDK-RSK-mTOR pathway activation...
  45. Zaal A, Nota B, Moore K, Dieker M, Van Ham S, ten Brinke A. TLR4 and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2, PI3K?, SGK1, and FOXO transcription factors. J Leukoc Biol. 2017;102:1035-1054 pubmed publisher
    ..box (FOX)O1 and FOXO3 and the signaling molecules serum- and glucocorticoid-inducible kinase (SGK1), ribosomal S6 kinase 2 (RSK2), and PI3K?...
  46. Khan T, Frey H. Comparison of real-world and certification emission rates for light duty gasoline vehicles. Sci Total Environ. 2018;622-623:790-800 pubmed publisher
    ..The purpose of this work is to compare regulatory limits (both CLs and emission standards) and the real-world emissions of LDGVs...
  47. Gawecka J, Young Robbins S, Sulzmaier F, Caliva M, Heikkila M, Matter M, et al. RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration. J Biol Chem. 2012;287:43424-37 pubmed publisher
    ..b>RSK2 functions downstream of Ras/Raf and promotes tumor cell motility and metastasis...
  48. Shi X, O Neill M, MacDonnell S, Brookes P, Yan C, Berk B. The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury. J Cardiovasc Pharmacol Ther. 2016;21:177-86 pubmed publisher
    During ischemia/reperfusion (I/R), ribosomal S6 kinase (RSK) activates Na(+)/H(+) exchanger 1 (NHE1) by phosphorylating NHE1 at serine 703 (pS703-NHE1), which promotes cardiomyocyte death and injury...
  49. Kim J, Lee K. Silkworm Thorn Stem Extract Targets RSK2 and Suppresses Solar UV-Induced Cyclooxygenase-2 Expression. Int J Mol Sci. 2015;16:25096-107 pubmed publisher
    ..SWE inhibited RSK2 activity, and pull-down assays using SWE-Sepharose beads revealed that SWE binds directly with RSK2 in an ATP-..
  50. Yang D, Lee K, Ko C, Moh S, Song J, Hur L, et al. Leucine-enkephalin promotes wound repair through the regulation of hemidesmosome dynamics and matrix metalloprotease. Peptides. 2016;76:57-64 pubmed publisher
    ..We show here that L-ENK induced activation of Erk, P90(RSK), and Elk-1 and promoted the disruption of hemidesmosomes and the expression of matrix metalloprotease (MMP)-2 and ..
  51. Braat M, van den Hoven A, van Doormaal P, Bruijnen R, Lam M, van den Bosch M. The Caudate Lobe: The Blind Spot in Radioembolization or an Overlooked Opportunity?. Cardiovasc Intervent Radiol. 2016;39:847-54 pubmed publisher
    ..In untreated CLs, significant hypertrophy was observed with a median volume increase of 33 % (p = 0.02)...
  52. Meyer Demott M, Jakobsen M, Wentzel Larsen T, Heir T. A controlled early group intervention study for unaccompanied minors: Can Expressive Arts alleviate symptoms of trauma and enhance life satisfaction?. Scand J Psychol. 2017;58:510-518 pubmed publisher
    ..post-traumatic stress symptoms (PTSS), general psychological distress (HSCL-25A), current life satisfaction (CLS) and expected life satisfaction (ELS)...
  53. Oh Y, Yue P, Zhou W, Balko J, Black E, Owonikoko T, et al. Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J Biol Chem. 2012;287:257-67 pubmed publisher
    ..Importantly, we have elucidated that Ras induces DR5 expression through co-activation of ERK/RSK and JNK signaling pathways and subsequent cooperative effects among the transcriptional factors CHOP, Elk1, and c-..
  54. Aris J, Alvers A, Ferraiuolo R, Fishwick L, Hanvivatpong A, Hu D, et al. Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast. Exp Gerontol. 2013;48:1107-19 pubmed publisher
    ..Here we examine the requirements for autophagy during extension of chronological life span (CLS) by calorie restriction (CR)...
  55. Reynolds A, Ou S. Generative Mechanisms in Early Childhood Interventions: A Confirmatory Research Framework for Prevention. Prev Sci. 2016;17:794-805 pubmed publisher
    ..preventive interventions for children from birth to age 5, including evidence from the Chicago Longitudinal Study (CLS), which investigates the impact of an established school-based early childhood intervention...
  56. Sulley A, Young G, Hunt C. Factors in the success of new contact lens wearers. Cont Lens Anterior Eye. 2017;40:15-24 pubmed publisher
    To determine the first-year retention rate for patients fitted with contact lenses (CLs) and identify factors associated with retention and dropout...
  57. Diec J, Naduvilath T, Tilia D, Papas E, Lazon de la Jara P. Discrimination of subjective responses between contact lenses with a novel questionnaire. Cont Lens Anterior Eye. 2017;40:367-381 pubmed publisher
    ..Two silicone-hydrogel CLs and a lens care solution (LCS) [Combinations A & B] were selected based on prior performance identifying best/..
  58. Zhao Y, Bjorbaek C, Moller D. Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases. J Biol Chem. 1996;271:29773-9 pubmed
    Each of the three known mammalian 90-kDa S6 kinase (pp90(rsk)) isoforms (RSK1, RSK2, and RSK3) was expressed in transfected cells and further characterized...
  59. Ihle M, Mai S, Siebert W. Treatment for acetabular dysplasia using the uncemented RM acetabular component - a 20 year follow-up. Hip Int. 2010;20:94-101 pubmed
    ..results of 93 consecutive uncemented THAs in 80 patients using the titanium-coated RM acetabular component and the CLS femoral component in a prospective study...
  60. Azimi A, Tuominen R, Costa Svedman F, Caramuta S, Pernemalm M, Frostvik Stolt M, et al. Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells. Cell Death Dis. 2017;8:e3029 pubmed publisher
    ..AKT and RSK, both reported to induce EPHA2 S897 phosphorylation, were also dephosphorylated after inhibition of CD13/ANPEP...
  61. Casciaro B, Dutta D, Loffredo M, Marcheggiani S, McDermott A, Willcox M, et al. Esculentin-1a derived peptides kill Pseudomonas aeruginosa biofilm on soft contact lenses and retain antibacterial activity upon immobilization to the lens surface. Biopolymers. 2017;: pubmed publisher
    ..Here, we have analyzed the activity of the peptides on P. aeruginosa biofilm formed on soft CLs. Microbiological assays and scanning electron microscopy analysis indicated that the peptides were able to disrupt ..
  62. Lagarde J, Uszczynska Ratajczak B, Carbonell S, Pérez Lluch S, Abad A, Davis C, et al. High-throughput annotation of full-length long noncoding RNAs with capture long-read sequencing. Nat Genet. 2017;: pubmed publisher
    ..To accelerate lncRNA annotation, the GENCODE consortium has developed RNA Capture Long Seq (CLS), which combines targeted RNA capture with third-generation long-read sequencing...
  63. Zheng Fischhöfer Q, Biernat J, Mandelkow E, Illenberger S, Godemann R, Mandelkow E. Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation. Eur J Biochem. 1998;252:542-52 pubmed
    ..Knowledge of the events and kinases generating the AT100 epitope in cells might allow us to study the degeneration of the cytoskeleton in Alzheimer's disease. ..
  64. Woods Y, Cohen P, Becker W, Jakes R, Goedert M, Wang X, et al. The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase. Biochem J. 2001;355:609-15 pubmed
    ..Phosphorylation of Thr(212) primes tau for phosphorylation by GSK3 at Ser(208) in vitro, suggesting a more general role for DYRK isoforms in priming phosphorylation of GSK3 substrates. ..
  65. Lehman J, Gomez Cambronero J. Molecular crosstalk between p70S6k and MAPK cell signaling pathways. Biochem Biophys Res Commun. 2002;293:463-9 pubmed
    ..Thus, a connection between these two kinases extends from the molecular level to cell migration, a key functionality in non-proliferative, mature phagocytes such as neutrophils. ..
  66. Sheffler D, Kroeze W, Garcia B, Deutch A, Hufeisen S, Leahy P, et al. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc Natl Acad Sci U S A. 2006;103:4717-22 pubmed
    ..We report here that genetic deletion of p90 ribosomal S6 kinase 2 (RSK2) potentiates GPCR signaling...
  67. Park Y, Nam H, Do M, Lee J. The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles. Exp Mol Med. 2016;48:e250 pubmed publisher
    RSK2, also known as RPS6KA3 (ribosomal protein S6 kinase, 90 kDa, polypeptide 3), is a downstream kinase of the mitogen-activated protein kinase (MAPK) pathway, which is important in regulating survival, transcription, growth and ..
  68. Whittaker R, Hothi H, Eskelinen A, Blunn G, Skinner J, Hart A. Variation in taper surface roughness for a single design effects the wear rate in total hip arthroplasty. J Orthop Res. 2017;35:1784-1792 pubmed publisher
    ..003) and the Skewness (Rsk, the asymmetry of the height distribution corresponding to the height or depth of surface features) (p?=?0.03)...
  69. Lin J, Spolski R, Leonard W. Critical role for Rsk2 in T-lymphocyte activation. Blood. 2008;111:525-33 pubmed
    ..report that interleukin 2 (IL-2) and IL-15, but not IL-7, rapidly activate the p90 ribosomal S6 kinases, Rsk1 and Rsk2, in human T lymphocytes...
  70. Kakugawa S, Shimojima M, Goto H, Horimoto T, Oshimori N, Neumann G, et al. Mitogen-activated protein kinase-activated kinase RSK2 plays a role in innate immune responses to influenza virus infection. J Virol. 2009;83:2510-7 pubmed publisher
    ..Here, we report that the ribosomal protein S6 kinase alpha 3 (RSK2), which is activated through the "classical" mitogen-activated protein kinase ..
  71. Jin L, Li D, Lee J, Elf S, Alesi G, Fan J, et al. p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms. Mol Cell Biol. 2013;33:2574-85 pubmed publisher
    How invasive and metastatic tumor cells evade anoikis induction remains unclear. We found that knockdown of RSK2 sensitizes diverse cancer cells to anoikis induction, which is mediated through phosphorylation targets including apoptosis ..
  72. Slaby S, Hanotel J, Marchand G, Lescuyer A, Bodart J, Leprêtre A, et al. Maturation of Xenopus laevis oocytes under cadmium and lead exposures: Cell biology investigations. Aquat Toxicol. 2017;193:105-110 pubmed publisher
    ..At last, cadmium exposures altered the MAPK pathway, regarding the activation of ERK2 and RSK, but also the activation and the activity of the MPF, by disturbing the state of phosphorylation of Cdc2 and ..
  73. Jacquot S, Merienne K, Pannetier S, Blumenfeld S, Schinzel A, Hanauer A. Germline mosaicism in Coffin-Lowry syndrome. Eur J Hum Genet. 1998;6:578-82 pubmed
    ..a Coffin-Lowry syndrome pedigree where the disorder is associated with a novel splice site mutation in the RSK2 gene, leading to in-phase skipping of exon 5...
  74. Louie D, Gloor K, Galasinski S, Resing K, Ahn N. Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry. Protein Sci. 2000;9:170-9 pubmed
    ..These results suggest that phosphorylation of HMG-14 and -7 interferes with nuclear localization mechanisms in a manner favoring release from nuclei. ..
  75. Peng C, Cho Y, Zhu F, Xu Y, Wen W, Ma W, et al. RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway. FASEB J. 2010;24:3490-9 pubmed publisher
    The ribosomal S6 kinase 2 (RSK2) is a well-known serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK) family of proteins. It is activated downstream of the MEK/ERKs cascade by mitogenic stimuli such as EGF or TPA...
  76. Mathew S, Nieves B, Sequeira S, Sambandamoorthy S, Pumiglia K, Larsen M, et al. Integrins promote cytokinesis through the RSK signaling axis. J Cell Sci. 2014;127:534-45 pubmed publisher
    ..Constitutively active RSK2 also restores cytokinesis inhibited by the mutant integrin...
  77. Galan J, Geraghty K, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, et al. Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3. Proc Natl Acad Sci U S A. 2014;111:E2918-27 pubmed publisher
    ..As such, this pathway is frequently deregulated in several types of cancer, including most cases of melanoma. RSK (p90 ribosomal S6 kinase) is a MAPK-activated protein kinase required for melanoma growth and proliferation, but ..
  78. Cho Y. RSK2 and its binding partners in cell proliferation, transformation and cancer development. Arch Pharm Res. 2017;40:291-303 pubmed publisher
    b>RSK2 is a serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK; RSKs) family, which regulates cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF), 12-O-..
  79. Camastra S, Vitali A, Anselmino M, Gastaldelli A, Bellini R, Berta R, et al. Muscle and adipose tissue morphology, insulin sensitivity and beta-cell function in diabetic and nondiabetic obese patients: effects of bariatric surgery. Sci Rep. 2017;7:9007 pubmed publisher
    ..GS, intracapillary neutrophils and higher intramyocellular fat, adipocyte area in VAT, crown-like structures (CLS) in VAT and SAT with rare structures (cyst-like) ~10-fold larger than CLS...
  80. Tanoue T, Maeda R, Adachi M, Nishida E. Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions. EMBO J. 2001;20:466-79 pubmed
  81. Yang T, Chow C. Elucidating protein: DNA complex by oligonucleotide DNA affinity purification. Methods Mol Biol. 2012;809:75-84 pubmed publisher
    ..with in-gel kinase assays to detect phosphotransferase activity, we were able to identify p90 ribosomal S6 kinase (RSK) and p70 S6 kinase (S6K) that are present in the NFAT:DNA complex...
  82. Daskalopoulou M, Rodger A, Phillips A, Sherr L, Elford J, McDonnell J, et al. Condomless sex in HIV-diagnosed men who have sex with men in the UK: prevalence, correlates, and implications for HIV transmission. Sex Transm Infect. 2017;93:590-598 pubmed publisher
    HIV transmission is ongoing among men who have sex with men (MSM) in the UK. Sex without a condom (condomless sex, CLS) is the main risk factor. We investigated the prevalence of and factors associated with types of CLS.
  83. Peng C, Zhu F, Wen W, Yao K, Li S, Zykova T, et al. Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway. J Biol Chem. 2012;287:25881-92 pubmed publisher
    ..Notably, we showed that EGF induces ribosomal S6 kinase 2 (RSK2) ubiquitination, and knocking down TRAF2 suppresses ubiquitination of RSK2 induced by EGF...
  84. No Y, He P, Yoo B, Yun C. Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2. Am J Physiol Cell Physiol. 2015;309:C14-21 pubmed publisher
    ..Additionally, we show that RSK2, but not RSK1, is responsible for NHE3 regulation...
  85. Kim J, Heo Y, Lee K. Osajin Inhibits Solar UV-Induced Cyclooxygenase-2 Expression Through Direct Inhibition of RSK2. J Cell Biochem. 2017;118:4080-4087 pubmed publisher
    ..Osajin inhibited transactivation of these transcription factors. We identified RSK2 as an inhibitory target of osajin by screening against 68 kinases related to inflammation...
  86. Hines K, Waalkes A, Penewit K, Holmes E, Salipante S, Werth B, et al. Characterization of the Mechanisms of Daptomycin Resistance among Gram-Positive Bacterial Pathogens by Multidimensional Lipidomics. mSphere. 2017;2: pubmed publisher
    ..strain pairs, such as reduced phosphatidylglycerols (PGs), while also revealing additional changes in cardiolipins (CLs), lysyl-PGs, and glycolipids. Whole-genome sequencing of the S. aureus and C...
  87. Zeniou M, Pannetier S, Fryns J, Hanauer A. Unusual splice-site mutations in the RSK2 gene and suggestion of genetic heterogeneity in Coffin-Lowry syndrome. Am J Hum Genet. 2002;70:1421-33 pubmed
    ..CLS is caused by mutations in a gene that is located in Xp22.2 and that encodes RSK2, a growth-factor-regulated protein kinase...
  88. Soulet F, Bailly K, Roga S, Lavigne A, Amalric F, Bouche G. Exogenously added fibroblast growth factor 2 (FGF-2) to NIH3T3 cells interacts with nuclear ribosomal S6 kinase 2 (RSK2) in a cell cycle-dependent manner. J Biol Chem. 2005;280:25604-10 pubmed
    ..FGF-2 added exogenously to NIH3T3 cells enters the nucleus and interacts with the nuclear active 90-kDa ribosomal S6 kinase 2 (RSK2) in a cell cycle-dependent manner...
  89. Vaghefi N, Kikkert J, Bolton M, Hanson L, Secor G, Nelson S, et al. Global genotype flow in Cercospora beticola populations confirmed through genotyping-by-sequencing. PLoS ONE. 2017;12:e0186488 pubmed publisher
    ..Cercospora beticola was confirmed as the species predominantly isolated from leaves with Cercospora leaf spot (CLS) symptoms. However, C. cf. flagellaris also was detected at a frequency of 3% in two table beet fields in New York...
  90. Miyazawa M, Subbaramaiah K, Bhardwaj P, Zhou X, Wang H, Falcone D, et al. Pioglitazone Inhibits Periprostatic White Adipose Tissue Inflammation in Obese Mice. Cancer Prev Res (Phila). 2018;11:215-226 pubmed publisher
    ..that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by crown-like structures (CLS) consisting of dead or dying adipocytes surrounded by macrophages, was associated with high-grade prostate cancer...
  91. Suzuki Y, Rahman M, Mitsuya H. Diverse transcriptional response of CD4+ T cells to stromal cell-derived factor SDF-1: cell survival promotion and priming effects of SDF-1 on CD4+ T cells. J Immunol. 2001;167:3064-73 pubmed
    ..SDF-1 also primed resting CD4(+) T cells for cytokine- and TCR-mediated stimuli. These data suggest that the SDF-1-mediated cell survival combined with its priming function would set T cells to respond to immunologic challenges. ..
  92. Hinsby A, Olsen J, Bennett K, Mann M. Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry. Mol Cell Proteomics. 2003;2:29-36 pubmed