RPS6

Summary

Gene Symbol: RPS6
Description: ribosomal protein S6
Alias: 40S ribosomal protein S6, phosphoprotein NP33, small ribosomal subunit protein eS6
Species: human
Products:     RPS6

Top Publications

  1. Villacé P, Marion R, Ortin J. The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. Nucleic Acids Res. 2004;32:2411-20 pubmed
    ..These results support the notion that the hStaufen-containing granules are structures essential in the localization and regulated translation of human mRNAs in vivo...
  2. Suber T, Nikolli I, O Brien M, Londino J, Zhao J, Chen K, et al. FBXO17 promotes cell proliferation through activation of Akt in lung adenocarcinoma cells. Respir Res. 2018;19:206 pubmed publisher
    ..Ectopically expressed FBXO17 also increased ERK1/2 kinase activation and increased phosphorylation of RPS6, a downstream target of mTOR...
  3. Xu L, Chen Y, Dutra Clarke M, Mayakonda A, Hazawa M, Savinoff S, et al. BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A. 2017;114:3981-3986 pubmed publisher
    ..protein/extracellular signal-regulated kinase kinase-extracellular signal-regulated kinase) and S6K-RPS6 (ribosomal protein S6 kinase-ribosomal protein S6) axes...
  4. Wu Y, Bi Y, Tan Z, Xie L, Xu H, Fan H, et al. Tanshinone I inhibits vascular smooth muscle cell proliferation by targeting insulin-like growth factor-1 receptor/phosphatidylinositol-3-kinase signaling pathway. Eur J Pharmacol. 2019;853:93-102 pubmed publisher
    ..glycogen synthase kinase-3 beta (GSK3β), mammalian target of rapamycin (mTOR), 70S6K, and ribosomal protein S6 (RPS6)...
  5. Fittschen M, Lastres Becker I, Halbach M, Damrath E, Gispert S, Azizov M, et al. Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate. Neurogenetics. 2015;16:181-92 pubmed publisher
    ..Quantitative immunoblots substantiated the increased abundance of NOP10, RPS3, RPS6, RPS10, RPS18, GNB2L1 in SDS protein fractions, and of PABPC1...
  6. Tessier S, Zhang J, Biggar K, Wu C, Pifferi F, Perret M, et al. Regulation of the PI3K/AKT Pathway and Fuel Utilization During Primate Torpor in the Gray Mouse Lemur, Microcebus murinus. Genomics Proteomics Bioinformatics. 2015;13:91-102 pubmed publisher
    ..an increase in phospho-glycogen synthase kinase 3α (GSK3α) and decrease in phospho-ribosomal protein S6 (RPS6) in the heart, and a decrease in phospho-mammalian target of rapamycin (mTOR) in the kidney...
  7. Jeong W, Seo H, Sung Y, Ka H, Song G, Kim J. Lysophosphatidic Acid (LPA) Receptor 3-Mediated LPA Signal Transduction Pathways: A Possible Relationship with Early Development of Peri-Implantation Porcine Conceptus. Biol Reprod. 2016;94:104 pubmed publisher
    ..signal-regulated kinase 1/2 (ERK1/2), ribosomal protein S6 kinase 90 kDa (P90RSK), ribosomal protein S6 (RPS6), and P38 in pTr cells...
  8. Sun J, Mao L, Yang H, Ren D. Critical role for the Tsc1-mTORC1 pathway in ?-cell mass in Pdx1-deficient mice. J Endocrinol. 2018;238:151-163 pubmed publisher
    ..cells increases phosphorylation of initiation factor 4E-binding protein 1 (4E-BP1) phosphorylation and 40S ribosomal protein S6, two downstream targets of mTORC1 indicating that Tsc1 mediates mTORC1 downregulation induced by Pdx1 ..
  9. Bermudez Silva F, Romero Zerbo S, Haissaguerre M, Ruz Maldonado I, Lhamyani S, El Bekay R, et al. The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice. Dis Model Mech. 2016;9:51-61 pubmed publisher
    ..1 µM while increasing phosphorylation of p70S6K1 and ribosomal protein S6 (rpS6) within the islets...

More Information

Publications136 found, 100 shown here

  1. Kang H, Kumar D, Liao G, Lichti Kaiser K, Gerrish K, Liao X, et al. GLIS3 is indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation. J Clin Invest. 2017;127:4326-4337 pubmed publisher
    ..cells was due to the inhibition of TSH-mediated activation of the mTOR complex 1/ribosomal protein S6 (mTORC1/RPS6) pathway as well as the reduced expression of several cell division-related genes regulated directly by GLIS3...
  2. Shives K, Massey A, May N, Morrison T, Beckham J. 4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression. Viruses. 2016;8: pubmed
    ..We also show that the canonical signals of mTORC1 activation including ribosomal protein s6 (rpS6) and S6K phosphorylation are not required for WNV growth in these same conditions...
  3. Zeng N, Prodhan U, D Souza R, Ramzan F, Mitchell S, Sharma P, et al. Regulation of Amino Acid Transporters and Sensors in Response to a High protein Diet: A Randomized Controlled Trial in Elderly Men. J Nutr Health Aging. 2019;23:354-363 pubmed publisher
    ..Instead, total ribosomal protein S6 (RPS6) was upregulated with 2RDA...
  4. Houddane A, Bultot L, Novellasdemunt L, Johanns M, Gueuning M, Vertommen D, et al. Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes. Cell Signal. 2017;34:23-37 pubmed publisher
    ..of the translation factors eukaryotic initiation factor-4E-binding protein-1 (4E-BP1) and ribosomal protein S6 (rpS6)...
  5. Muller Delp J, Hotta K, Chen B, Behnke B, Maraj J, Delp M, et al. Effects of age and exercise training on coronary microvascular smooth muscle phenotype and function. J Appl Physiol (1985). 2017;:jap.00459.2017 pubmed publisher
    ..from aged rats; whereas expression of phospho-histone H3 and of the synthetic protein, ribosomal protein S6 (rpS6), were increased...
  6. Logan S, Wu C, Storey K. The squirrel with the lagging eIF2: Global suppression of protein synthesis during torpor. Comp Biochem Physiol A Mol Integr Physiol. 2018;227:161-171 pubmed publisher
    ..Translation resumes during interbout arousal when p-p70 S6K, p-rpS6, and p-4EBP levels returned to control values or above...
  7. Yi Y, You K, Bae E, Kwak S, Seong Y, Bae I. Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6. Int J Oncol. 2015;47:122-32 pubmed publisher
    ..In addition, SU11274/gefitinib combination synergistically reduced the level of ribosomal protein S6 (RPS6) in MSL subtype TNBC cells...
  8. Wang W, Zheng K, Gong X, Xu J, Huang J, Lin D, et al. The rice TCD11 encoding plastid ribosomal protein S6 is essential for chloroplast development at low temperature. Plant Sci. 2017;259:1-11 pubmed publisher
    ..and molecular complementation showed that TCD11 encodes the ribosomal small subunit protein S6 in chloroplasts (RPS6). TCD11 was abundantly expressed in leaves, suggesting its different expressions in tissues...
  9. Koren S, Hamm M, Meier S, Weiss B, Nation G, Chishti E, et al. Tau drives translational selectivity by interacting with ribosomal proteins. Acta Neuropathol. 2019;137:571-583 pubmed publisher
    ..extended these results to human brains and found that tau pathologically interacts with ribosomal protein S6 (rpS6 or S6), a crucial regulator of translation...
  10. Hashimoto M, Sato T, Muroyama Y, Fujimura L, Hatano M, Saito T. Nepro is localized in the nucleolus and essential for preimplantation development in mice. Dev Growth Differ. 2015;57:529-38 pubmed publisher
    ..Furthermore, at the morula stage, whereas 18S rRNA and ribosomal protein S6 (rpS6), which are components of the ribosome, were distributed to the cytoplasm in WT embryos, they were mainly localized ..
  11. Xiao H, Wang H, Silva E, Thompson J, Guillou A, Yates J, et al. The Pallbearer E3 ligase promotes actin remodeling via RAC in efferocytosis by degrading the ribosomal protein S6. Dev Cell. 2015;32:19-30 pubmed publisher
    ..Here we show that the F-box protein PALL interacts with phosphorylated ribosomal protein S6 (RpS6) to promote its ubiquitylation and proteasomal degradation...
  12. Mas S, Gassó P, Boloc D, Rodriguez N, Mármol F, Sánchez J, et al. Network analysis of gene expression in mice provides new evidence of involvement of the mTOR pathway in antipsychotic-induced extrapyramidal symptoms. Pharmacogenomics J. 2016;16:293-300 pubmed publisher
    ..Moreover, we also showed differences in the phosphorylation pattern of the ribosomal protein S6 (rpS6), which is a major downstream effector of mTOR...
  13. Wilkins S, Islam M, Gannon J, Markolovic S, Hopkinson R, Ge W, et al. JMJD5 is a human arginyl C-3 hydroxylase. Nat Commun. 2018;9:1180 pubmed publisher
    ..from human regulator of chromosome condensation domain-containing protein 1 (RCCD1) and ribosomal protein S6 (RPS6)...
  14. Astone M, Pizzi M, Peron M, Domenichini A, Guzzardo V, Töchterle S, et al. A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish. PLoS ONE. 2015;10:e0145178 pubmed publisher
    ..Interestingly, among ia2 deleted genes we identified the presence of the 40S ribosomal protein S6 gene that may be one of the possible drivers for the MPNSTs in ia2 mutants...
  15. Xu T, Cardoso F, Pineda A, Trevisi E, Shen X, Rosa F, et al. Grain challenge affects systemic and hepatic molecular biomarkers of inflammation, stress, and metabolic responses to a greater extent in Holstein than Jersey cows. J Dairy Sci. 2017;100:9153-9162 pubmed publisher
    ..Expression of phosphorylated p70S6K1, RPS6, and 4EBP1 proteins, as well as total mechanistic target of rapamycin (mTOR) protein, decreased in Holsteins fed ..
  16. Mazumder A, Sharma P, Patial V, Singh D. Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation. J Ethnopharmacol. 2017;204:8-17 pubmed publisher
    ..GBbf treatment attenuated ribosomal S6 and pS6 proteins, and hippocampal mTOR, Rps6 and Rps6kb1 mRNA levels...
  17. Nakanishi R, Hirayama Y, Tanaka M, Maeshige N, Kondo H, Ishihara A, et al. Nucleoprotein supplementation enhances the recovery of rat soleus mass with reloading after hindlimb unloading-induced atrophy via myonuclei accretion and increased protein synthesis. Nutr Res. 2016;36:1335-1344 pubmed publisher
    ..the HUR + NP group had larger soleus muscles and fiber cross-sectional areas, higher levels of phosphorylated rpS6, and higher numbers of myonuclei and myogenin-positive cells...
  18. Lager S, Jansson T, Powell T. Differential regulation of placental amino acid transport by saturated and unsaturated fatty acids. Am J Physiol Cell Physiol. 2014;307:C738-44 pubmed publisher
    ..In contrast, OA increased amino acid transport and phosphorylation of ERK, mTOR, S6 kinase 1, and rpS6. The combination of DHA with OA increased amino acid transport and rpS6 phosphorylation...
  19. Rapanelli M, Frick L, Pogorelov V, Ota K, Abbasi E, Ohtsu H, et al. Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome. Eur Neuropsychopharmacol. 2014;24:1896-906 pubmed publisher
    ..find dephosphorylation of Akt and its target GSK3β and activation of the MAPK signaling cascade and its target rpS6; these are characteristic of the effects of DA on D2- and D1-expressing striatal neurons, respectively...
  20. Urtishak K, Wang L, Culjkovic Kraljacic B, Davenport J, Porazzi P, Vincent T, et al. Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia. Oncogene. 2019;38:2241-2262 pubmed publisher
    ..and/or translation of the corresponding mRNAs, as well as reduced phosphorylation of the p-AKT1, p-EIF4EBP1, p-RPS6 and p-EIF4E signaling proteins...
  21. Dai W, Wang Q, Zhao F, Liu J, Liu H. Understanding the regulatory mechanisms of milk production using integrative transcriptomic and proteomic analyses: improving inefficient utilization of crop by-products as forage in dairy industry. BMC Genomics. 2018;19:403 pubmed publisher
    ..HMGCS1), less amino acid/protein transport (SLC38A2, SLC7A8, RAB5a, VPS18), reduced protein translation (RPS6, RPS12, RPS16, RPS19, RPS20, RPS27), more proteasome- (PSMC2, PSMC6, PSMD14, PSMA2, PSMA3) and ubiquitin-mediated ..
  22. Rapanelli M, Frick L, Pogorelov V, Ohtsu H, Bito H, Pittenger C. Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders. Transl Psychiatry. 2017;7:e1013 pubmed publisher
    ..This was associated with elevations in phosphorylation of rpS6, a sensitive marker of neural activity, in the dorsal striatum...
  23. Hansji H, Leung E, Baguley B, Finlay G, Cameron Smith D, Figueiredo V, et al. ZFAS1: a long noncoding RNA associated with ribosomes in breast cancer cells. Biol Direct. 2016;11:62 pubmed
    ..ZFAS1 knockdown significantly reduced RPS6 phosphorylation...
  24. Um S, Sticker Jantscheff M, Chau G, Vintersten K, Mueller M, Gangloff Y, et al. S6K1 controls pancreatic ? cell size independently of intrauterine growth restriction. J Clin Invest. 2015;125:2736-47 pubmed publisher
    ..of S6K1 in ? cells of S6K1-/- mice restored embryonic ? cell size, insulin levels, glucose tolerance, and RPS6 phosphorylation, without rescuing IUGR...
  25. Ramani M, Kumar R, Halloran B, Lal C, Ambalavanan N, McMahon L. Supraphysiological Levels of Oxygen Exposure During the Neonatal Period Impairs Signaling Pathways Required for Learning and Memory. Sci Rep. 2018;8:9914 pubmed publisher
    ..Hyperoxia decreased hippocampal mGLU7, TrkB, AKT, ERK2, mTORC1, RPS6, and EIF4E and increased ?3, ?5, and ?2 subunits of GABAA receptor and PTEN proteins, although changes ..
  26. Mazumder A, Patial V, Singh D. Mycophenolate mofetil contributes to downregulation of the hippocampal interleukin type 2 and 1β mediated PI3K/AKT/mTOR pathway hyperactivation and attenuates neurobehavioral comorbidities in a rat model of temporal lobe epilepsy. Brain Behav Immun. 2019;75:84-93 pubmed publisher
    ..Furthermore, the hippocampal mRNA level of IL-1β, IL-2, PI3K, AKT, HIF-1α, RAPTOR, mTOR, Rps6kb1 and Rps6 was found to be decreased in MMF treated animals...
  27. Wu X, Dou Y, Yang Y, Bian D, Luo J, Tong B, et al. Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway. Biochem Pharmacol. 2015;96:323-36 pubmed publisher
    ..pathway in T cells as demonstrated by down-regulated phosphorylation of the downstream target genes p70S6K and RPS6, and it functioned independent of two well-known upstream kinases PI3K/AKT and ERK...
  28. Jeong W, Kim J, Bazer F, Song G. Proliferation-stimulating effect of colony stimulating factor 2 on porcine trophectoderm cells is mediated by activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase. PLoS ONE. 2014;9:e88731 pubmed publisher
    ..CSF2 in pTr cell culture medium at 20 ng/ml significantly induced phosphorylation of AKT1, ERK1/2, MTOR, p70RSK and RPS6 protein, but not STAT3 protein...
  29. Kim H, Banerjee N, Ivanov I, Pfent C, Prudhomme K, Bisson W, et al. Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. Mol Nutr Food Res. 2016;60:1912-23 pubmed publisher
    ..Pomegranate decreased p70S6K and RPS6, as well as Rps6ka2, Map2k2, and Mapk1 mRNA...
  30. Li C, Fang F, Chen Y, Liu T, Chan T, Yu S, et al. Overexpressed Fatty Acid Synthase in Gastrointestinal Stromal Tumors: Targeting a Progression-Associated Metabolic Driver Enhances the Antitumor Effect of Imatinib. Clin Cancer Res. 2017;23:4908-4918 pubmed publisher
    ..induced LC3-II and myristoylated AKT-suppressible activity of caspases 3 and 7, attenuated the PI3K/AKT/mTOR/RPS6/4E-BP1 pathway activation, and exhibited dose-dependent therapeutic additivism with imatinib...
  31. Steiner J, Bardgett M, Wolfgang L, Lang C, Stocker S. Glucocorticoids attenuate the central sympathoexcitatory actions of insulin. J Neurophysiol. 2014;112:2597-604 pubmed publisher
    ..Western blot analysis indicates insulin produced similar activation of Akt Ser(473) and rpS6 Ser(240/244) in the ventral hypothalamus of control and dexamethasone-treated rats...
  32. Liu X, Müller F, Wayne A, Pastan I. Protein Kinase Inhibitor H89 Enhances the Activity of Pseudomonas Exotoxin A-Based Immunotoxins. Mol Cancer Ther. 2016;15:1053-62 pubmed publisher
    ..kinase A; it was partially recapitulated by inhibition of S6K1, which led to inactivation of its downstream targets rpS6 and GSK3β, resulting in a fall in MCL1 levels...
  33. Miller W, Ravi S, Martin T, Kimball S, Dennis M. Activation of the Stress Response Kinase JNK (c-Jun N-terminal Kinase) Attenuates Insulin Action in Retina through a p70S6K1-dependent Mechanism. J Biol Chem. 2017;292:1591-1602 pubmed publisher
    ..mutations in the autoinhibitory domain and was more sensitive to inhibition of the kinase as compared with rpS6. Notably, rictor and IRS-1 phosphorylation by p70S6K1 attenuate insulin action through a negative feedback pathway...
  34. Della Sala G, Putignano E, Chelini G, Melani R, Calcagno E, Michele Ratto G, et al. Dendritic Spine Instability in a Mouse Model of CDKL5 Disorder Is Rescued by Insulin-like Growth Factor 1. Biol Psychiatry. 2016;80:302-311 pubmed publisher
    ..Exogenous administration of IGF-1 rescued defective rpS6 phosphorylation, spine density, and PSD-95 expression...
  35. Pogue Geile K, Geiser J, Shu M, Miller C, Wool I, Meisler A, et al. Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein. Mol Cell Biol. 1991;11:3842-9 pubmed
    ..These results suggest that there is increased synthesis of ribosomes in colorectal tumors and that this increase is an early event in colon neoplasia. ..
  36. Fragiadakis G, Baca Q, Gherardini P, Ganio E, Gaudilliere D, Tingle M, et al. Mapping the Fetomaternal Peripheral Immune System at Term Pregnancy. J Immunol. 2016;197:4482-4492 pubmed
    ..tone that are unique to a mother and her offspring, including increased ERK1/2, MAPK-activated protein kinase 2, rpS6, and CREB phosphorylation in fetal Tbet+CD4+ T cells, CD8+ T cells, B cells, and ..
  37. Chen W, Dittmer D. Ribosomal protein S6 interacts with the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Virol. 2011;85:9495-505 pubmed publisher
    ..Here, we show that ribosomal protein S6 (RPS6) interacts with LANA. This interaction is mediated by the N-terminal domain of LANA and does not require DNA or RNA...
  38. Salmond R, Brownlie R, Meyuhas O, Zamoyska R. Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation. J Immunol. 2015;195:4615-22 pubmed publisher
    ..Ribosomal protein S6 (rpS6) is an essential component of the ribosome and is inducibly phosphorylated following mTOR activation in eukaryotic ..
  39. Juli G, Gismondi A, Monteleone V, Caldarola S, Iadevaia V, Aspesi A, et al. Depletion of ribosomal protein S19 causes a reduction of rRNA synthesis. Sci Rep. 2016;6:35026 pubmed publisher
    ..A similar effect is observed upon depletion of RPS6 or RPL11...
  40. Gopinath S. Inhibition of Stat3 signaling ameliorates atrophy of the soleus muscles in mice lacking the vitamin D receptor. Skelet Muscle. 2017;7:2 pubmed publisher
    ..mammalian target of rapamycin (mTOR) signaling components, ribosomal S6 kinase (p70S6K) and ribosomal S6 protein (rpS6), that regulate protein synthesis and cell size, respectively...
  41. Puighermanal E, Biever A, Pascoli V, Melser S, Pratlong M, Cutando L, et al. Ribosomal Protein S6 Phosphorylation Is Involved in Novelty-Induced Locomotion, Synaptic Plasticity and mRNA Translation. Front Mol Neurosci. 2017;10:419 pubmed publisher
    The phosphorylation of the ribosomal protein S6 (rpS6) is widely used to track neuronal activity...
  42. Kido K, Sato K, Makanae Y, Ato S, Hayashi T, Fujita S. Herbal supplement Kamishimotsuto augments resistance exercise-induced mTORC1 signaling in rat skeletal muscle. Nutrition. 2016;32:108-13 pubmed publisher
    ..muscle protein synthesis (MPS) and by western blotting analysis to assess the phosphorylation of p70S6K (Thr389), rpS6 (Ser240/244), and Akt (Ser473 and Thr308)...
  43. Chuang Y, Yang J, Yang D, Lin T, Liou C, Chen S. Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury. Int J Mol Sci. 2015;16:26406-16 pubmed publisher
    ..In addition, sestrin2 may also regulate ribosomal protein S6 (RpS6), a molecule important for protein synthesis, through the effect of mammalian target of rapamycin (mTOR) complex ..
  44. Li S, Loor J, Liu H, Liu L, Hosseini A, Zhao W, et al. Optimal ratios of essential amino acids stimulate β-casein synthesis via activation of the mammalian target of rapamycin signaling pathway in MAC-T cells and bovine mammary tissue explants. J Dairy Sci. 2017;100:6676-6688 pubmed publisher
    ..The OPAA had no effect on the mTOR phosphorylation status but increased the phosphorylation of S6K1 and RPS6. When the MTE were treated with rapamycin in the presence of OPAA, the expression of β-casein was markedly ..
  45. Fyfe J, Bishop D, Bartlett J, Hanson E, Anderson M, Garnham A, et al. Enhanced skeletal muscle ribosome biogenesis, yet attenuated mTORC1 and ribosome biogenesis-related signalling, following short-term concurrent versus single-mode resistance training. Sci Rep. 2018;8:560 pubmed publisher
    ..However, during the final training session, RT further increased both mTORC1 (p70S6K1 and rps6 phosphorylation) and 45S pre-rRNA transcription-related signalling (TIF-1A and UBF phosphorylation) versus ..
  46. Xu H, Shen L, Chen X, Ding Y, He J, Zhu J, et al. mTOR/P70S6K promotes spermatogonia proliferation and spermatogenesis in Sprague Dawley rats. Reprod Biomed Online. 2016;32:207-17 pubmed publisher
    ..was positively related with spermatogenesis by detecting mTOR expression and the expression of its target p70s6k, rps6 and 4e-bp1 at different developmental stages...
  47. Piva A, Gerace E, Di Chio M, Osanni L, Padovani L, Caffino L, et al. The metaplastic effects of NMDA receptors blockade on reactivation of instrumental memories in rats. Neurobiol Learn Mem. 2018;154:87-96 pubmed publisher
    ..24?h and 7?d after reactivation) or ex-vivo assessment of transcription factor Zif268 and ribosomal protein rpS6 phosphorylation in nucleus accumbens (NAc) and amygdala (Amy)...
  48. Rosner M, Schipany K, Hengstschlager M. Phosphorylation of nuclear and cytoplasmic pools of ribosomal protein S6 during cell cycle progression. Amino Acids. 2013;44:1233-40 pubmed publisher
    Of all known ribosomal proteins, the 40S ribosomal protein S6 is by far the most extensively studied. Still, little is known about some basic aspects of S6 regulation including its cell cycle-related expression and localization...
  49. Jaramillo M, Ammar D, Quispe R, Guzmán F, Margis R, Nazari E, et al. Identification and evaluation of reference genes for expression studies by RT-qPCR during embryonic development of the emerging model organism, Macrobrachium olfersii. Gene. 2017;598:97-106 pubmed publisher
    ..Thus, the aim of this study was to evaluate the expression stability of six genes (?-act, GAPDH, EF-1?, RpL8, RpS6, AK) in embryos and in adult tissues (cerebral ganglia, muscle and hepatopancreas) of M. olfersii...
  50. Corrick K, Stec M, Merritt E, Windham S, Thomas S, Cross J, et al. Serum from human burn victims impairs myogenesis and protein synthesis in primary myoblasts. Front Physiol. 2015;6:184 pubmed publisher
    ..assessed via caspase-3 and ubiquitin levels), but reduced anabolic signaling [p-p70S6k (Ser421/Thr424), -30%; p-rpS6 (Ser240/244), ≈-50%] and impaired protein synthesis (-24%) (P < 0.05)...
  51. Gonzalez A, Hoffman J, Townsend J, Jajtner A, Boone C, Beyer K, et al. Intramuscular anabolic signaling and endocrine response following high volume and high intensity resistance exercise protocols in trained men. Physiol Rep. 2015;3: pubmed publisher
    ..Phosphorylation status of all other signaling proteins including mTOR, p70S6k, and RPS6 were not significantly different between trials...
  52. Chen B, Tan Z, Gao J, Wu W, Liu L, Jin W, et al. Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer. J Exp Clin Cancer Res. 2015;34:126 pubmed publisher
    Ribosomal protein S6 (rpS6), a component of the 40S ribosomal subunit, is involved in multiple cellular bioactivities. However, its clinicopathological significance in non-small cell lung cancer (NSCLC) is poorly understood...
  53. Lee D, Kuo H, Chen C, Hsu J, Chou C, Wei Y, et al. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell. 2007;130:440-55 pubmed
    ..Our findings identify a pathway that is critical for inflammation-mediated tumor angiogenesis and may provide a target for clinical intervention in human cancer. ..
  54. Lagares Tena L, García Monclús S, López Alemany R, Almacellas Rabaiget O, Huertas Martínez J, Sáinz Jaspeado M, et al. Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway. Oncotarget. 2016;7:56889-56903 pubmed publisher
    ..Analysis of the phosphorylation profile of CAV1-silenced cells showed a decrease of p-ribosomal protein S6 (RPS6). RPS6 can be phosphorylated by p90 ribosomal S6 kinases (RSK) proteins...
  55. Campos Parra A, Padua Bracho A, Pedroza Torres A, Figueroa González G, Fernandez Retana J, Millan Catalan O, et al. Comprehensive transcriptome analysis identifies pathways with therapeutic potential in locally advanced cervical cancer. Gynecol Oncol. 2016;143:406-413 pubmed publisher
    ..the overexpression of the relevant genes of each pathway, such as NOTCH1, JAK2, STAM1, SOS1, ADAM17, PSEN1, NCSTN, RPS6, STK11/LKB1 and MLTS8/GBL in LACC compared with normal cervical tissue epithelia...
  56. Garami A, Zwartkruis F, Nobukuni T, Joaquin M, Roccio M, Stocker H, et al. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell. 2003;11:1457-66 pubmed
    ..Finally, coexpression of a human TSC2 cDNA harboring a disease-associated point mutation in the GAP domain, failed to stimulate Rheb GTPase activity or block Rheb activation of S6K1. ..
  57. Jeong W, Lee J, Bazer F, Song G, Kim J. Fibroblast growth factor 4-induced migration of porcine trophectoderm cells is mediated via the AKT cell signaling pathway. Mol Cell Endocrinol. 2016;419:208-16 pubmed publisher
    ..9-fold at 20 ng/ml FGF4. Within 30 min after treatment with 20 ng/ml FGF4, the abundances of p-AKT, p-P90RSK and p-RPS6 proteins increased 2.1-, 5.2- and 3.2-fold, respectively, and then returned to basal levels by 120 min...
  58. Meyuhas O. Ribosomal Protein S6 Phosphorylation: Four Decades of Research. Int Rev Cell Mol Biol. 2015;320:41-73 pubmed publisher
    The phosphorylation of ribosomal protein S6 (rpS6) has been described for the first time about four decades ago...
  59. Marques N, Sese M, Cánovas V, Valente F, Bermudo R, de Torres I, et al. Regulation of protein translation and c-Jun expression by prostate tumor overexpressed 1. Oncogene. 2014;33:1124-34 pubmed publisher
    ..These results unveil new functions of PTOV1 in the regulation of protein translation and in the progression of prostate cancer to an invasive and metastatic disease. ..
  60. Volovelsky O, Cohen G, Kenig A, Wasserman G, Dreazen A, Meyuhas O, et al. Phosphorylation of Ribosomal Protein S6 Mediates Mammalian Target of Rapamycin Complex 1-Induced Parathyroid Cell Proliferation in Secondary Hyperparathyroidism. J Am Soc Nephrol. 2016;27:1091-101 pubmed publisher
    ..by either chronic hypocalcemia or uremia, which was measured by increased phosphorylation of ribosomal protein S6 (rpS6), a downstream target of the mTOR pathway. This activation correlated with increased parathyroid cell proliferation...
  61. Yerlikaya S, Meusburger M, Kumari R, Huber A, Anrather D, Costanzo M, et al. TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae. Mol Biol Cell. 2016;27:397-409 pubmed publisher
    ..Revisiting this enigma in Saccharomyces cerevisiae, we found that the regulation of Rps6 phosphorylation on Ser-232 and Ser-233 is mediated by both TOR complex 1 (TORC1) and TORC2...
  62. Mobley C, Hornberger T, Fox C, Healy J, Ferguson B, Lowery R, et al. Effects of oral phosphatidic acid feeding with or without whey protein on muscle protein synthesis and anabolic signaling in rodent skeletal muscle. J Int Soc Sports Nutr. 2015;12:32 pubmed publisher
    ..PA, WPC and PA + WPC resulted in a significant elevation in the phosphorylation of mTOR (Ser2481) and rps6 (Ser235/236) (p < 0...
  63. Dungan C, Williamson D. Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis. Biochem Biophys Res Commun. 2017;482:1067-1072 pubmed publisher
    ..activation (IRS-1 Y1222, MEK1/2 S217/221, ERK1/2 T202/Y204), REDD1, and mTOR signaling activation (S6K1 T389, rpS6 S240/244) were examined in skeletal muscle collected before and after a 10 min insulin treatment...
  64. Remy I, Michnick S. Visualization of biochemical networks in living cells. Proc Natl Acad Sci U S A. 2001;98:7678-83 pubmed
    ..Our results demonstrate the feasibility of using this strategy in efforts of genomewide functional annotation. ..
  65. Glover E, Oates B, Tang J, Moore D, Tarnopolsky M, Phillips S. Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men. Am J Physiol Regul Integr Comp Physiol. 2008;295:R604-10 pubmed publisher
    ..the phosphorylation of Akt and the downstream 70 kDa S6 protein kinase (p70S6K1, Thr389) and ribosomal protein S6 (rpS6, Ser235/236, Ser240/244; all P<0.05)...
  66. Bursac S, Brdovcak M, Pfannkuchen M, Orsolic I, Golomb L, Zhu Y, et al. Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proc Natl Acad Sci U S A. 2012;109:20467-72 pubmed publisher
    ..These findings may have important implications with respect to understanding the pathogenesis of diseases caused by impaired ribosome biogenesis...
  67. Xu J, Chen J, Dong Z, Meyuhas O, Chen J. Phosphorylation of ribosomal protein S6 mediates compensatory renal hypertrophy. Kidney Int. 2015;87:543-56 pubmed publisher
    ..Here we generated congenic ribosomal protein S6 (rpS6) knock-in mice expressing nonphosphorylatable rpS6 and found that uninephrectomy-induced renal hypertrophy was ..
  68. Esnault S, Kelly E, Shen Z, Johansson M, Malter J, Jarjour N. IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils. J Immunol. 2015;195:2529-39 pubmed publisher
    ..that, unlike GM-CSF or IL-5, IL-3 triggers prolonged signaling through activation of ribosomal protein S6 (RPS6) and the upstream kinase 90-kDa ribosomal S6 kinase (p90S6K)...
  69. Le Sage V, Cinti A, Valiente Echeverría F, Mouland A. Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation. Virol J. 2015;12:138 pubmed publisher
    ..hits identified in the BioID screen were validated by immunoprecipation and confirmed the interaction of DDX17 and RPS6 with HIV-1 Gag...
  70. Kearney A, Fan Y, Giri U, Saigal B, Gandhi V, Heymach J, et al. 8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition. PLoS ONE. 2015;10:e0135962 pubmed publisher
    ..measured by AMPK and ACC phosphorylation, and subsequently caused dephosphorylation of p70S6K and ribosomal protein RPS6 in the sensitive cell lines...
  71. Nihonmatsu I, Ohkawa N, Saitoh Y, Inokuchi K. Targeting of ribosomal protein S6 to dendritic spines by in vivo high frequency stimulation to induce long-term potentiation in the dentate gyrus. Biol Open. 2015;4:1387-94 pubmed publisher
    ..One regulator of translational processes is ribosomal protein S6 (rpS6), a component of the small 40S ribosomal subunit...
  72. Szabo A, Fekete T, Koncz G, Kumar B, Pazmandi K, Foldvari Z, et al. RIG-I inhibits the MAPK-dependent proliferation of BRAF mutant melanoma cells via MKP-1. Cell Signal. 2016;28:335-347 pubmed publisher
    ..first study showing that RIG-I activation results in MKP-1-mediated inhibition of cell proliferation via controlling the p38-HSP27, c-Jun and rpS6 pathways thus identifying RIG-I and MKP-1 as novel and promising therapeutical targets.
  73. Winkelmann D, Kahan L. Immunochemical accessibility of ribosomal protein S4 in the 30 S ribosome. The interaction of S4 with S5 and S12. J Mol Biol. 1983;165:357-74 pubmed
    ..The effect of S5 and S12 on S4 accessibility is consistent with data from a variety of other approaches, suggesting that these proteins form a structural and functional domain in the small ribosomal subunit. ..
  74. Kim T, Jang C, Kim H, Lee J, Ahn B, Kim J. Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation. Mol Biol Cell. 2006;17:824-33 pubmed
    ..Furthermore, ribosomal protein S6 (rpS6) also interacted with Hsp90 and exhibited a similar effect upon treatment with Hsp90 inhibitors...
  75. Lekmine F, Sassano A, Uddin S, Smith J, Majchrzak B, Brachmann S, et al. Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp Cell Res. 2004;295:173-82 pubmed
  76. Ohji G, Hidayat S, Nakashima A, Tokunaga C, Oshiro N, Yoshino K, et al. Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin. J Biochem. 2006;139:129-35 pubmed
    ..The protein kinase activity of S6K as well as the phosphorylation of the substrate, 40S ribosomal protein S6, were lowered in the geldanamycin-treated cells...
  77. Kappeler K, Zhang J, Dinh T, Strom J, Chen Q. Histone deacetylase 6 associates with ribosomes and regulates de novo protein translation during arsenite stress. Toxicol Sci. 2012;127:246-55 pubmed publisher
    ..These data demonstrate that HDAC6 was recruited to ribosomes, physically interacted with ribosomal proteins, and regulated de novo protein translation in keratinocytes responding to arsenite stress. ..
  78. Li S, Kong Y, Si L, Chi Z, Cui C, Sheng X, et al. Phosphorylation of mTOR and S6RP predicts the efficacy of everolimus in patients with metastatic renal cell carcinoma. BMC Cancer. 2014;14:376 pubmed publisher
    ..levels of phosphorylated AKT, mTOR, eukaryotic initiation factor 4E (eIF4E) binding protein-1 (4EBP1) and 40S ribosomal protein S6 (S6RP) by immunohistochemistry...
  79. Martorelli D, Muraro E, Mastorci K, Dal Col J, Faè D, Furlan C, et al. A natural HIV p17 protein variant up-regulates the LMP-1 EBV oncoprotein and promotes the growth of EBV-infected B-lymphocytes: implications for EBV-driven lymphomagenesis in the HIV setting. Int J Cancer. 2015;137:1374-85 pubmed publisher
  80. Holz M, Ballif B, Gygi S, Blenis J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell. 2005;123:569-80 pubmed
    ..Thus, the eIF3 preinitiation complex acts as a scaffold to coordinate a dynamic sequence of events in response to stimuli that promote efficient protein synthesis. ..
  81. Fujita K, Ito H, Nakano S, Kinoshita Y, Wate R, Kusaka H. Immunohistochemical identification of messenger RNA-related proteins in basophilic inclusions of adult-onset atypical motor neuron disease. Acta Neuropathol. 2008;116:439-45 pubmed publisher
    ..Moreover, the BIs were not immunopositive for TDP-43. Our results imply that translation attenuation could be involved in the processes of BI formation in this disorder. ..
  82. Calvisi D, Wang C, Ho C, Ladu S, Lee S, Mattu S, et al. Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology. 2011;140:1071-83 pubmed publisher
    ..De novo lipogenesis has pathogenic and prognostic significance for HCC. Inhibitors of lipogenic signaling, including those that inhibit the AKT pathway, might be useful as therapeutics for patients with liver cancer. ..
  83. Lu X, Ma J, Chu J, Shao Q, Zhang Y, Lu G, et al. MiR-129-5p Sensitizes the Response of Her-2 Positive Breast Cancer to Trastuzumab by Reducing Rps6. Cell Physiol Biochem. 2017;44:2346-2356 pubmed publisher
    ..predict target genes of miR-129-5p, and luciferase assays were carried out to confirm the binding of miR-129-5p and rpS6. MiR-129-5p, which was downregulated and predicted to target rpS6 in trastuzumab-resistant breast cancer cells, ..
  84. Hutchinson J, Shanware N, Chang H, Tibbetts R. Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. J Biol Chem. 2011;286:8688-96 pubmed publisher
    Ribosomal protein S6 (rpS6) is a critical component of the 40 S ribosomal subunit that mediates translation initiation at the 5'-m(7)GpppG cap of mRNA...
  85. Hager M, Haufe H, Alinger B, Kolbitsch C. pS6 Expression in normal renal parenchyma, primary renal cell carcinomas and their metastases. Pathol Oncol Res. 2012;18:277-83 pubmed publisher
    ..In approximately one-third of the cases pS6 overexpression was found exclusively in metastases, which is interesting with regard to the association between high pS6 expression and sensitivity to mTOR inhibitor therapy. ..
  86. Cuppens T, Annibali D, Coosemans A, Trovik J, ter Haar N, Colas E, et al. Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas-an ENITEC Group Initiative. Clin Cancer Res. 2017;23:1274-1285 pubmed publisher
    ..i>Clin Cancer Res; 23(5); 1274-85. ©2017 AACR. ..
  87. Ilina E, Armento A, Sanchez L, Reichlmeir M, Braun Y, Penski C, et al. Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux. Oncotarget. 2017;8:67567-67591 pubmed publisher
    ..we show that sCPE activates mTORC1 signaling in glioma cells detectable by phosphorylation of its downstream target RPS6. Additionally, sCPE diminishes glioma cell migration associated with a negative regulation of Rac1 signaling via ..
  88. Pata I, Hoth S, Kruppa J, Metspalu A. The human ribosomal protein S6 gene: isolation, primary structure and location in chromosome 9. Gene. 1993;127:275-6 pubmed
  89. Schl fli P, Tr ger J, Eckhardt K, Borter E, Spielmann P, Wenger R. Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN. FEBS J. 2011;278:1757-68 pubmed publisher
  90. Boulay K, Ghram M, Viranaicken W, Trépanier V, Mollet S, Fréchina C, et al. Cell cycle-dependent regulation of the RNA-binding protein Staufen1. Nucleic Acids Res. 2014;42:7867-83 pubmed publisher
    ..Our results point out for the first time to the possibility that Stau1 participates in a mechanism of post-transcriptional regulation of gene expression that is linked to cell cycle progression in cancer cells. ..
  91. Fischer D, Manfredsson F, Kemp C, Cole Strauss A, Lipton J, Duffy M, et al. Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal ?-Synuclein Overexpression. Sci Rep. 2017;7:16356 pubmed publisher
    ..syn overexpression increased phosphorylation of ribosomal protein S6 (p-rpS6) in SNpc neurons, a readout of trkB activation...
  92. Robledo S, Idol R, Crimmins D, Ladenson J, Mason P, Bessler M. The role of human ribosomal proteins in the maturation of rRNA and ribosome production. RNA. 2008;14:1918-29 pubmed publisher
    ..We depleted HeLa cells using siRNA for several individual r-proteins of the small (RPS6, RPS7, RPS15, RPS16, RPS17, RPS19, RPS24, RPS25, RPS28) or large subunit (RPL5, RPL7, RPL11, RPL14, RPL26, RPL35a) ..