RPL5

Summary

Gene Symbol: RPL5
Description: ribosomal protein L5
Alias: MSTP030, PPP1R135, uL18, 60S ribosomal protein L5, large ribosomal subunit protein uL18, protein phosphatase 1, regulatory subunit 135
Species: human
Products:     RPL5

Top Publications

  1. Pogue Geile K, Geiser J, Shu M, Miller C, Wool I, Meisler A, et al. Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein. Mol Cell Biol. 1991;11:3842-9 pubmed
    ..These results suggest that there is increased synthesis of ribosomes in colorectal tumors and that this increase is an early event in colon neoplasia. ..
  2. Dai M, Lu H. Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. J Biol Chem. 2004;279:44475-82 pubmed
    ..We propose that the MDM2-L5-L11-L23 complex functions to inhibit MDM2-mediated p53 ubiquitination and thus activates p53. ..
  3. Sun X, Dai M, Lu H. 5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction. J Biol Chem. 2007;282:8052-9 pubmed
    ..These results demonstrate that 5-FU treatment triggers a ribosomal stress response so that ribosomal proteins L5, L11, and L23 are released from ribosome to activate p53 by ablating the MDM2-p53 feedback circuit. ..
  4. Zhang Y, Wolf G, Bhat K, Jin A, Allio T, Burkhart W, et al. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol. 2003;23:8902-12 pubmed
    ..We suggest that L11 functions as a negative regulator of HDM2 and that there might exist in vivo an L11-HDM2-p53 pathway for monitoring ribosomal integrity. ..
  5. Steitz J, Berg C, Hendrick J, La Branche Chabot H, Metspalu A, Rinke J, et al. A 5S rRNA/L5 complex is a precursor to ribosome assembly in mammalian cells. J Cell Biol. 1988;106:545-56 pubmed
    ..Indirect immunofluorescence indicates that the L5/5S complex is concentrated in the nucleolus. L5 may therefore play a role in delivering 5S rRNA to the nucleolus for assembly into ribosomes. ..
  6. Dai M, Zeng S, Jin Y, Sun X, David L, Lu H. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol. 2004;24:7654-68 pubmed
    ..These results reveal that L23 is another regulator of the p53-MDM2 feedback regulation. ..
  7. Li M, Gu W. A critical role for noncoding 5S rRNA in regulating Mdmx stability. Mol Cell. 2011;43:1023-32 pubmed publisher
    ..These results provide insights into the differential effects on p53 and Mdmx by Mdm2 in vivo and reveal a critical role for noncoding 5S rRNA in modulating the p53-Mdmx axis. ..
  8. Bursac S, Brdovcak M, Pfannkuchen M, Orsolic I, Golomb L, Zhu Y, et al. Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proc Natl Acad Sci U S A. 2012;109:20467-72 pubmed publisher
    ..These findings may have important implications with respect to understanding the pathogenesis of diseases caused by impaired ribosome biogenesis...
  9. Dai M, Sun X, Lu H. Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2. Mol Cell Biol. 2008;28:4365-76 pubmed publisher
    ..These results suggest that a p53-dependent cell cycle checkpoint monitors changes of cellular NS levels via the impediment of MDM2 function. ..

More Information

Publications117 found, 100 shown here

  1. Horn H, Vousden K. Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway. Oncogene. 2008;27:5774-84 pubmed publisher
    ..We further showed that the ability of L11 to bind the 5S rRNA is important for the cooperation with L5, and a mutant L11, which cannot bind the 5S rRNA, cannot cooperate with L5 in inhibiting MDM2. ..
  2. . Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet. 2009;41:824-8 pubmed publisher
    ..We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3...
  3. Sun X, Wang Y, Xirodimas D, Dai M. Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation. J Biol Chem. 2010;285:25812-21 pubmed publisher
    ..These results demonstrate that NEDDylation of L11 plays a critical role in mediating p53 activation in response to perturbation of ribosomal biogenesis...
  4. Marechal V, Elenbaas B, Piette J, Nicolas J, Levine A. The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes. Mol Cell Biol. 1994;14:7414-20 pubmed
  5. Hafler D, Compston A, Sawcer S, Lander E, Daly M, De Jager P, et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med. 2007;357:851-62 pubmed
    ..94x10(-7)) and multiple SNPs in the HLA-DRA locus (P=8.94x10(-81)). Alleles of IL2RA and IL7RA and those in the HLA locus are identified as heritable risk factors for multiple sclerosis. ..
  6. Dissanayaka Mudiyanselage S, Qu J, Tian N, Jiang J, Wang Y. Potato Spindle Tuber Viroid RNA-Templated Transcription: Factors and Regulation. Viruses. 2018;10: pubmed publisher
    ..The expression of TFIIIA-7ZF, particularly the splicing event, is regulated by a ribosomal protein (RPL5)...
  7. Cao P, Yang A, Wang R, Xia X, Zhai Y, Li Y, et al. Germline Duplication of SNORA18L5 Increases Risk for HBV-related Hepatocellular Carcinoma by Altering Localization of Ribosomal Proteins and Decreasing Levels of p53. Gastroenterology. 2018;155:542-556 pubmed publisher
    ..ribosome biogenesis, increasing levels of mature 18S and 28S ribosomal RNAs and causing the ribosomal proteins RPL5 and RPL11 to stay in the nucleolus, which kept them from binding to MDM2...
  8. Nagahama M, Hara Y, Seki A, Yamazoe T, Kawate Y, Shinohara T, et al. NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal protein L5 through its nucleolar localization sequence. Mol Biol Cell. 2004;15:5712-23 pubmed
    ..The physiological implication of this interaction was suggested by the finding that a dominant negative NVL2 mutant inhibits ribosome biosynthesis, which is known to take place in the nucleolus. ..
  9. Calviño F, Kharde S, Ori A, Hendricks A, Wild K, Kressler D, et al. Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site. Nat Commun. 2015;6:6510 pubmed publisher
    During 60S biogenesis, mature 5S RNP consisting of 5S RNA, RpL5 and RpL11, assembles into a pre-60S particle, where docking relies on RpL11 interacting with helix 84 (H84) of the 25S RNA...
  10. Asano N, Kato K, Nakamura A, Komoda K, Tanaka I, Yao M. Structural and functional analysis of the Rpf2-Rrs1 complex in ribosome biogenesis. Nucleic Acids Res. 2015;43:4746-57 pubmed publisher
    ..These proteins are necessary for the recruitment of three ribosomal components (5S ribosomal RNA [rRNA], RpL5 and RpL11) to the 90S ribosome precursor and subsequent 27SB pre-rRNA processing...
  11. Liu S, Tackmann N, Yang J, Zhang Y. Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis. Oncogene. 2017;36:1374-1383 pubmed publisher
    ..In lymphoma, both p19ARF and ribosomal proteins RPL11 and RPL5 respond to c-MYC activation to induce p53...
  12. Jiang J, Smith H, Ren D, Dissanayaka S, Dawe A, Wang L, et al. Potato spindle tuber viroid modulates its replication through a direct interaction with a splicing regulator. J Virol. 2018;: pubmed publisher
    ..showing that potato spindle tuber viroid (PSTVd) interacts with a TFIIIA splicing regulator (ribosomal protein L5; RPL5) in vitro and in vivo PSTVd infection compromises the regulatory role of RPL5 over splicing of ..
  13. Baßler J, Paternoga H, Holdermann I, Thoms M, Granneman S, Barrio Garcia C, et al. A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. J Cell Biol. 2014;207:481-98 pubmed publisher
    ..We show that Rsa4 is connected to the central protuberance by binding to Rpl5 and to ribosomal RNA (rRNA) helix 89 of the nascent peptidyl transferase center (PTC) through Nsa2...
  14. Errichiello E, Vetro A, Mina T, Wischmeijer A, Berrino E, Carella M, et al. Whole exome sequencing in the differential diagnosis of Diamond-Blackfan anemia: Clinical and molecular study of three patients with novel RPL5 and mosaic RPS19 mutations. Blood Cells Mol Dis. 2017;64:38-44 pubmed publisher
    ..we unraveled the presence of pathogenic variants affecting genes already known to be involved in DBA pathogenesis (RPL5 and RPS19) in three patients with otherwise uncertain clinical diagnosis, and provided new insights on DBA genotype-..
  15. Delaporta P, Sofocleous C, Stiakaki E, Polychronopoulou S, Economou M, Kossiva L, et al. Clinical phenotype and genetic analysis of RPS19, RPL5, and RPL11 genes in Greek patients with Diamond Blackfan Anemia. Pediatr Blood Cancer. 2014;61:2249-55 pubmed publisher
    ..Clinical evaluation of patients and data collection was performed followed by the molecular analysis of RPS19, RPL5, and RPL11 genes. Mutation screening included PCR amplification, ECMA analysis, and direct sequencing...
  16. Nishimura K, Kumazawa T, Kuroda T, Katagiri N, Tsuchiya M, Goto N, et al. Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation. Cell Rep. 2015;10:1310-23 pubmed publisher
    The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation under ribotoxic stress...
  17. Wynn E, Christensen A. Are Synonymous Substitutions in Flowering Plant Mitochondria Neutral?. J Mol Evol. 2015;81:131-5 pubmed publisher
    ..Rps14 is co-transcribed with cob and rpl5 in most plant mitochondrial genomes, but in some genomes, rps14 has been duplicated to the nucleus leaving a ..
  18. Santiago E, Akamine P, Snider J, Wong V, Jessulat M, Deineko V, et al. Novel Interactome of Saccharomyces cerevisiae Myosin Type II Identified by a Modified Integrated Membrane Yeast Two-Hybrid (iMYTH) Screen. G3 (Bethesda). 2016;6:1469-74 pubmed publisher
    ..Eight proteins were confirmed by coprecipitation (Ape2, Bzz1, Fba1, Pdi1, Rpl5, Tah11, and Trx2) or mass spectrometry (AP-MS) (Abp1)...
  19. Wang R, Yoshida K, Toki T, Sawada T, Uechi T, Okuno Y, et al. Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia. Br J Haematol. 2015;168:854-64 pubmed publisher
    ..or large deletions in 11 ribosomal protein genes including RPS7, RPS10, RPS17, RPS19, RPS24, RPS26, RPS29, RPL5, RPL11, RPL26 and RPL35A as well as GATA1 in more than 50% of patients...
  20. Park J, Bae Y. Phosphorylation of ribosomal protein L5 by protein kinase CKII decreases its 5S rRNA binding activity. Biochem Biophys Res Commun. 1999;263:475-81 pubmed
    ..Based on our present results, we suggest that the phosphorylation of L5 by CKII is one of the mechanisms that regulates nucleolar targeting of 5S rRNA and/or ribosome assembly in the cell. ..
  21. Kusk M, Ahmed R, Thomsen B, Bendixen C, Issinger O, Boldyreff B. Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins. Mol Cell Biochem. 1999;191:51-8 pubmed
  22. Rojo Bartolomé I, Martínez Miguel L, Lafont A, Vílchez M, Asturiano J, Pérez L, et al. Molecular markers of oocyte differentiation in European eel during hormonally induced oogenesis. Comp Biochem Physiol A Mol Integr Physiol. 2017;211:17-25 pubmed publisher
    ..of genes related to 5S rRNA production (gtf3a), accumulation (gtf3a, 42sp43) and nucleocytoplasmic transport (rpl5, rpl11) and the 5S/18S rRNA index decreased (PV>EV>MV>LV>MN)...
  23. Rubio J, Stankovich J, Field J, Tubridy N, Marriott M, Chapman C, et al. Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians. Genes Immun. 2008;9:624-30 pubmed publisher
    ..001, IL2RA (rs2104286) P=0.033, RPL5 (rs6604026) P=0.041 and CD58 (rs12044852) P=0.042. There was no association (P=0...
  24. Li M, Rao M, Chen K, Zhou J, Song J. Selection of reference genes for gene expression studies in heart failure for left and right ventricles. Gene. 2017;620:30-35 pubmed publisher
    ..By using the qRT-PCR, the expression levels of ACTB, RAB7A, GAPDH, REEP5, RPL5, PSMB4 and VCP in eight heart failure and four normal heart samples were assessed...
  25. Arbiv O, Cuvelier G, Klaassen R, Fernandez C, Robitaille N, Steele M, et al. Molecular analysis and genotype-phenotype correlation of Diamond-Blackfan anemia. Clin Genet. 2017;: pubmed publisher
    ..Patients with RPS19 mutations had the fewest number of defects, while patients with RPL5 had the greatest number of birth defects.
  26. Keinan E, Abraham A, Cohen A, Alexandrov A, Mintz R, Cohen M, et al. High-Reynolds Microfluidic Sorting of Large Yeast Populations. Sci Rep. 2018;8:13739 pubmed publisher
    ..we demonstrate that protein quality control and expression of established yeast aging markers such as CalM, RPL5, and SAM1 may change after the very first replication events, rather than later in the aging process as previously ..
  27. Wang G, Zhao W, Yang Y, Yang G, Wei Z, Guo J. Identification of biomarkers of venous thromboembolism by bioinformatics analyses. Medicine (Baltimore). 2018;97:e0152 pubmed publisher
    ..family genes and NADH family-ubiquinol-cytochrome genes, were identified, such as ribosomal protein L9 (RPL9), RPL5, RPS20, RPL23, and tumor protein p53 (TP53)...
  28. Teng T, Mercer C, Hexley P, Thomas G, Fumagalli S. Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity. Mol Cell Biol. 2013;33:4660-71 pubmed publisher
    ..to insults that lead to cancer, including the binding and inhibition of Hdm2 by the 60S ribosomal proteins (RPs) RPL5 and RPL11...
  29. Yu W, Qiu Z, Gao N, Wang L, Cui H, Qian Y, et al. PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop. Nucleic Acids Res. 2011;39:2234-48 pubmed publisher
    ..Taken together, our results reveal that PAK1IP1 is a new nucleolar protein that is crucial for rRNA processing and plays a regulatory role in cell proliferation via the p53-MDM2 loop. ..
  30. Dong Z, Zhu C, Zhan Q, Jiang W. The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells. Oncotarget. 2017;8:13240-13252 pubmed publisher
    ..Perturbation of RRP15 induces nucleolar stress that activates RPL5/RPL11/5S rRNA (RP)-Mdm2-p53 axis checkpoint response and arrests cells at G1-G1/S in p53-proficient non-transformed ..
  31. He X, Xu Z. [Clinical features and pathogenic gene detection of Diamond-Blackfan anemia]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:171-175 pubmed
    ..In the other patient, gene screening showed a heterozygous mutation in RPL5 gene, c.740T>C (p. I247L), which had not been reported in literature, and there were no mutations in her parents...
  32. Pelava A, Schneider C, Watkins N. The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and disease. Biochem Soc Trans. 2016;44:1086-90 pubmed publisher
    ..The ribosomal assembly intermediate 5S RNP (ribonucleoprotein particle), containing RPL5, RPL11 and the 5S rRNA, accumulates when ribosome biogenesis is blocked...
  33. Massanella M, Singhania A, Beliakova Bethell N, Pier R, Lada S, White C, et al. Differential gene expression in HIV-infected individuals following ART. Antiviral Res. 2013;100:420-8 pubmed publisher
    ..g., ALOX12 and CYP2S1). Targets not confirmed by RT-qPCR (i.e., GSTM2 and RPL5) were significantly confirmed by droplet digital (ddPCR), which may represent a superior method when confirming ..
  34. Smetanina N, Mersiyanova I, Kurnikova M, Ovsyannikova G, Hachatryan L, Bobrynina V, et al. Clinical and genomic heterogeneity of Diamond Blackfan anemia in the Russian Federation. Pediatr Blood Cancer. 2015;62:1597-600 pubmed publisher
    ..patients and their first-degree relatives was sequenced for mutations in RPS19, RPS10, RPS24, RPS26, RPS7, RPS17, RPL5, RPL11, RPL35a, and GATA1...
  35. Perera D, Stankovich J, Butzkueven H, Taylor B, Foote S, Kilpatrick T, et al. Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus. J Neuroimmunol. 2009;211:105-9 pubmed publisher
    ..To dissect further the involvement of four recent identified MS susceptibility genes (KIAA0350, IL2RA, RPL5 and CD58) in disease pathogenesis, we genotyped 94 haplotype-tagging single nucleotide polymorphisms (SNPs) from ..
  36. Kharde S, Calviño F, Gumiero A, Wild K, Sinning I. The structure of Rpf2-Rrs1 explains its role in ribosome biogenesis. Nucleic Acids Res. 2015;43:7083-95 pubmed publisher
    ..The 5S RNP consisting of the 5S rRNA, RpL5 and RpL11 is recruited at an early stage, but has to rearrange during maturation of the pre-60S ribosomal subunit...
  37. Quarello P, Garelli E, Brusco A, Carando A, Mancini C, Pappi P, et al. High frequency of ribosomal protein gene deletions in Italian Diamond-Blackfan anemia patients detected by multiplex ligation-dependent probe amplification assay. Haematologica. 2012;97:1813-7 pubmed publisher
    ..to screen the six genes that are most frequently mutated in Diamond-Blackfan anemia patients: RPS17, RPS19, RPS26, RPL5, RPL11, and RPL35A. Using this assay we showed that deletions represent approximately 20% of all mutations...
  38. Ahamad J, Ojha S, Srivastava A, Bhattacharya A, Bhattacharya S. Post-transcriptional regulation of ribosomal protein genes during serum starvation in Entamoeba histolytica. Mol Biochem Parasitol. 2015;201:146-52 pubmed publisher
    ..we measured transcription of six selected RP genes from the small- and large-ribosomal subunits (RPS6, RPS3, RPS19, RPL5, RPL26, RPL30) representing the early-, mid-, and late-stages of ribosomal assembly...
  39. Steinberg Shemer O, Keel S, Dgany O, Walsh T, Noy Lotan S, Krasnov T, et al. Diamond Blackfan Anemia: A Nonclassical Patient With Diagnosis Assisted by Genomic Analysis. J Pediatr Hematol Oncol. 2016;38:e260-2 pubmed publisher
    ..was established by identification of a novel de novo mutation disrupting normal splicing of the ribosomal protein RPL5. The diagnosis of DBA was confirmed by elevated erythrocyte adenosine deaminase levels and an abnormal ribosomal ..
  40. Liao J, Zhou X, Gatignol A, Lu H. Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex. Oncogene. 2014;33:4916-23 pubmed publisher
    ..Here, we show that RPL5, co-operatively with RPL11, guides the RNA-induced silencing complex (RISC) to c-Myc mRNA and mediates the ..
  41. Hellwig B, Madjar K, Edlund K, Marchan R, Cadenas C, Heimes A, et al. Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy. PLoS ONE. 2016;11:e0167585 pubmed publisher
    ..Four of the ten late-type genes, the ribosome-related factors EIF4B, RPL5, RPL3, and the tumor angiogenesis modifier EPN3 were significantly associated with MFS in the late period also in a ..
  42. Oh W, Wu C, Kim S, Facchinetti V, Julien L, Finlan M, et al. mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 2010;29:3939-51 pubmed publisher
    ..Thus, mTORC2 can function cotranslationally by phosphorylating residues in nascent chains that are critical to attain proper conformation. Our findings reveal that mTOR links protein production with quality control. ..
  43. Goudarzi K, Lindström M. Role of ribosomal protein mutations in tumor development (Review). Int J Oncol. 2016;48:1313-24 pubmed publisher
    ..genes have for example been found in endometrial cancer (RPL22), T-cell acute lymphoblastic leukemia (RPL10, RPL5 and RPL11), chronic lymphocytic leukemia (RPS15), colorectal cancer (RPS20), and glioma (RPL5)...
  44. Wang R, Wei B, Wei J, Li Z, Tian Y, Du C. Caspase-related apoptosis genes in gliomas by RNA-seq and bioinformatics analysis. J Clin Neurosci. 2016;33:259-263 pubmed publisher
    ..which were significantly enriched in cellular components related functions (for example, TUBB2A, RPSA and RPL5); and metabolism related pathways (for example, PSMC3, KHSRP, RPL5 and RPSA)...
  45. Cai P, Mao X, Zhao J, Luo L. Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish. Biochem Biophys Res Commun. 2018;497:776-782 pubmed publisher
    ..Mutations in ribosome biogenesis protein Rps19, Rpl5, or Rpl11 can lead to hematopoietic defects in human, thus triggering the disease Diamond Blackfan anemia...
  46. Odintsova T, Müller E, Ivanov A, Egorov T, Bienert R, Vladimirov S, et al. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. J Protein Chem. 2003;22:249-58 pubmed
    ..For nine proteins (L3, L4, L5, L7A, L10, L14, L19, L31, and L40), the molecular masses could not be determined. Proteins P1 and protein L3-like were not identified by the methods applied. ..
  47. Sonoda M, Ishimura M, Ichimiya Y, Terashi E, Eguchi K, Sakai Y, et al. Atypical erythroblastosis in a patient with Diamond-Blackfan anemia who developed del(20q) myelodysplasia. Int J Hematol. 2018;108:228-231 pubmed publisher
    ..An anemic newborn was diagnosed with DBA due to RPL5 mutation (c.473_474del, p.K158SfsX26). Refractory anemia required regular transfusions and iron chelation therapy...
  48. Mobley C, Mumford P, Kephart W, Conover C, Beggs L, Balaez A, et al. Effects of testosterone treatment on markers of skeletal muscle ribosome biogenesis. Andrologia. 2016;48:967-977 pubmed publisher
    ..05). Finally, lower phospho-(Ser235/236)-to-total rps6 protein and lower rpl5 protein levels existed in ORX+TEST rats versus other treatments, suggesting that chronic TEST treatment may lower ..
  49. Wan Y, Zhang Q, Zhang Z, Song B, Wang X, Zhang Y, et al. Transcriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia. BMC Med Genomics. 2016;9:13 pubmed publisher
    ..Mutations in RPL5 are reported in approximately 9 ~ 21 % of DBA patients, which represents the most common pathological condition ..
  50. Fang Z, Cao B, Liao J, Deng J, Plummer K, Liao P, et al. SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer. elife. 2018;7: pubmed publisher
    ..Here, we identify SPIN1 (Spindlin 1) as a novel binding partner of human RPL5/uL18 that is important for this pathway...
  51. Choi J, Kim H, Kim K, Lee B, Lu W, An W. Selective requirement of H2B N-Terminal tail for p14ARF-induced chromatin silencing. Nucleic Acids Res. 2011;39:9167-80 pubmed publisher
    ..Our results thus reveal a hitherto unknown role of p14ARF in the regulation of chromatin transcription, as well as molecular mechanisms governing the repressive action of p14ARF. ..
  52. Hoppenbrouwers I, Aulchenko Y, Janssens A, Ramagopalan S, Broer L, Kayser M, et al. Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis. J Hum Genet. 2009;54:676-80 pubmed publisher
    ..Several of these risk genes, including CD58 and CLEC16A, are shared by different autoimmune diseases. Fine mapping studies will be needed to determine the functional contributions to distinct autoimmune phenotypes. ..
  53. Kim J, Cha J, Marshak D, Bae Y. Interaction of the beta subunit of casein kinase II with the ribosomal protein L5. Biochem Biophys Res Commun. 1996;226:180-6 pubmed
    ..The protein L5 may act as a regulator of the activity or subcellular localization of CKII. ..
  54. Madru C, Lebaron S, Blaud M, Delbos L, Pipoli J, Pasmant E, et al. Chaperoning 5S RNA assembly. Genes Dev. 2015;29:1432-46 pubmed publisher
    ..polymerase III and is assembled into the 5S ribonucleoprotein particle (RNP), containing ribosomal proteins Rpl5/uL18 and Rpl11/uL5, prior to its incorporation into preribosomes...
  55. Hofman I, van Duin M, de Bruyne E, Fancello L, Mulligan G, Geerdens E, et al. RPL5 on 1p22.1 is recurrently deleted in multiple myeloma and its expression is linked to bortezomib response. Leukemia. 2017;31:1706-1714 pubmed publisher
    ..1 encompassing two genes: ectopic viral integration site 5 (EVI5) and ribosomal protein L5 (RPL5). Low mRNA expression of EVI5 and RPL5 was associated with worse survival in diagnostic cases...
  56. Devlin J, Hannan K, Hein N, Cullinane C, Kusnadi E, Ng P, et al. Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma. Cancer Discov. 2016;6:59-70 pubmed publisher
    ..induced expression of the proapoptotic protein BMF that was independent of p53 and reduced expression of RPL11 and RPL5. Thus, targeting the network controlling the synthesis and function of ribosomes at multiple points provides a ..
  57. Nicolas E, Parisot P, Pinto Monteiro C, de Walque R, De Vleeschouwer C, Lafontaine D. Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress. Nat Commun. 2016;7:11390 pubmed publisher
    ..Remarkably, we find that uL5 (formerly RPL11) and uL18 (RPL5) are the strongest contributors to nucleolar integrity...
  58. Santos B, da Costa Diesel L, da Silva Meirelles L, Nardi N, Camassola M. Identification of suitable reference genes for quantitative gene expression analysis in rat adipose stromal cells induced to trilineage differentiation. Gene. 2016;594:211-219 pubmed publisher
    ..On the basis of a literature review, eight genes were selected: Actb, B2m, Hprt1, Ppia, Rplp0, Rpl13a, Rpl5, and Ywhaz...
  59. Pausch P, Singh U, Ahmed Y, Pillet B, Murat G, Altegoer F, et al. Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones. Nat Commun. 2015;6:7494 pubmed publisher
    ..Rrb1, Syo1, Sqt1 and Yar1) selectively enriched the mRNAs encoding their specific ribosomal protein clients (Rpl3, Rpl5, Rpl10 and Rps3)...
  60. Ge J, Apicella M, Mills J, Garçon L, French D, Weiss M, et al. Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia. PLoS ONE. 2015;10:e0134878 pubmed publisher
    ..We generated induced pluripotent stem cells from DBA patients carrying RPS19 or RPL5 mutations...
  61. Lindström M, Jin A, Deisenroth C, White Wolf G, Zhang Y. Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation. Mol Cell Biol. 2007;27:1056-68 pubmed
    ..Hence, the MDM2 central zinc finger plays a critical role in mediating MDM2's interaction with ribosomal proteins and its ability to degrade p53, and these roles are disrupted by human cancer-associated MDM2 mutations. ..
  62. Rudt F, Pieler T. Cytosolic import factor- and Ran-independent nuclear transport of ribosomal protein L5. Eur J Cell Biol. 2001;80:661-8 pubmed
    ..Thus, the presence of multiple NLSs in ribosomal protein L5 appears to allow for efficient nuclear transport via utilisation of multiple, mechanistically different import pathways. ..
  63. Quarello P, Garelli E, Carando A, Brusco A, Calabrese R, Dufour C, et al. Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations. Haematologica. 2010;95:206-13 pubmed publisher
    ..Two new genes (RPL5, RPL11), encoding for ribosomal proteins of the large subunit, have been reported to be involved in a considerable ..
  64. Jensen C, Stankovich J, van der Walt A, Bahlo M, Taylor B, van der Mei I, et al. Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients. PLoS ONE. 2010;5:e10003 pubmed publisher
    ..and replicated several single nucleotide polymorphism (SNP) susceptibility loci including CLEC16A, IL2RA, IL7R, RPL5, CD58, CD40 and chromosome 12q13-14 in addition to the well established allele HLA-DR15...
  65. Wu Z, Sloan D, Brown C, Rosenblueth M, Palmer J, Ong H. Mitochondrial Retroprocessing Promoted Functional Transfers of rpl5 to the Nucleus in Grasses. Mol Biol Evol. 2017;34:2340-2354 pubmed publisher
    ..the coexisting nuclear and mitochondrial gene copies that are established during these transfers, we have analyzed rpl5 genes from 90 grasses (Poaceae) and related monocots...
  66. Ogata K, Kurahashi A, Nishiyama C, Terao K. Presence of role of the 5SrRNA-L5 protein complex (5SRNP) in the threonyl- and histidyl-tRNA synthetase complex in rat liver cytosol. Biochim Biophys Acta. 1994;1218:388-400 pubmed
    ..This activity was inhibited by an antibody against protein L5, and the inhibition was reversed by addition of 5SRNP. These results indicate that 5SRNP plays a role as a positive effector of Thr-RS in the complex. ..
  67. Yu Y, Maggi L, Brady S, Apicelli A, Dai M, Lu H, et al. Nucleophosmin is essential for ribosomal protein L5 nuclear export. Mol Cell Biol. 2006;26:3798-809 pubmed
    ..Consistent with NPM's proposed role in ribosome biogenesis, we isolated ribosomal protein L5 (rpL5), a known chaperone for the 5S rRNA...
  68. Robledo S, Idol R, Crimmins D, Ladenson J, Mason P, Bessler M. The role of human ribosomal proteins in the maturation of rRNA and ribosome production. RNA. 2008;14:1918-29 pubmed publisher
    ..individual r-proteins of the small (RPS6, RPS7, RPS15, RPS16, RPS17, RPS19, RPS24, RPS25, RPS28) or large subunit (RPL5, RPL7, RPL11, RPL14, RPL26, RPL35a) and studied the effect on rRNA processing and ribosome production...
  69. Frigerio J, Dagorn J, Iovanna J. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. Biochim Biophys Acta. 1995;1262:64-8 pubmed
    ..No correlation could however be made between the level of expression and the severity of the disease. Yet, abnormal patterns with additional larger transcripts were observed in some patients for rpL5, rpL28 and rpS10.
  70. Jin Y, Wang S, Tai J, Zhang J, Chen F, Shi J, et al. [The difference expression and diagnostic value of RPL5 in papillary thyroid carcinoma of children and adults]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017;52:830-834 pubmed publisher
    b>Objective: To study the difference expression and diagnostic value of ribosomal protein L5 (RPL5) in papillary thyroid carcinoma (PTC) of children and adults...
  71. Turi Z, Senkyrikova M, Mistrik M, Bartek J, Moudry P. Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cells. Cell Cycle. 2017;:1-27 pubmed publisher
    ..of HEATR1 also caused disruption of nucleolar structure and activated the ribosomal biogenesis stress pathway - RPL5 / RPL11 dependent stabilization and activation of p53...
  72. Boldyreff B, Issinger O. A-Raf kinase is a new interacting partner of protein kinase CK2 beta subunit. FEBS Lett. 1997;403:197-9 pubmed
    ..At the site of CK2 beta, residue 175 and amino acids between residues 194 and 200 are likely to be involved in direct interaction. ..
  73. Frum R, Busby S, Ramamoorthy M, Deb S, Shabanowitz J, Hunt D, et al. HDM2-binding partners: interaction with translation elongation factor EF1alpha. J Proteome Res. 2007;6:1410-7 pubmed
    ..Because EF1alpha has been implicated in DNA replication and severing of microtubules, interaction of HDM2 with EF1alpha may signify a p53-independent cell growth regulatory role of HDM2. ..
  74. Jäkel S, Gorlich D. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO J. 1998;17:4491-502 pubmed
    ..The presence of distinct binding sites for rpL23a and the M9 import signal in transportin, and for rpL23a and importin alpha in importin beta might explain how a single receptor can recognize very different import signals. ..
  75. Ahn B, Kim T, Bae Y. Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins. Mol Cells. 2001;12:158-63 pubmed
    ..These results suggest that the binding sites of CKIIbeta for these target proteins are not located within a small linear sequence stretch, but rather are created by a three-dimensional structure. ..
  76. Fregoso O, Das S, Akerman M, Krainer A. Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence. Mol Cell. 2013;50:56-66 pubmed publisher
    ..Furthermore, they implicate the RPL5-MDM2 complex in OIS and demonstrate a link between spliceosomal and ribosomal components, functioning independently ..
  77. Jin A, Itahana K, O KEEFE K, Zhang Y. Inhibition of HDM2 and activation of p53 by ribosomal protein L23. Mol Cell Biol. 2004;24:7669-80 pubmed
  78. Cmejla R, Cmejlova J, Handrkova H, Petrak J, Petrtylova K, Mihal V, et al. Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond-Blackfan anemia. Hum Mutat. 2009;30:321-7 pubmed publisher
    ..Recently, mutations in RPL5, RPL11, and RPL35a of the large ribosomal subunit have also been reported in several DBA patients...
  79. Takagi M, Absalon M, McLure K, Kastan M. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell. 2005;123:49-63 pubmed
    ..These findings demonstrate the importance of increased translation of p53 in DNA-damage responses and suggest critical roles for RPL26 and nucleolin in affecting p53 induction. ..
  80. Zhou X, Hao Q, Zhang Q, Liao J, Ke J, Liao P, et al. Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition. Cell Death Differ. 2015;22:755-66 pubmed publisher
    ..Herein, we report that RPL5 and RPL11 can also enhance the transcriptional activity of a p53 homolog TAp73, but through a distinct mechanism...
  81. Cao B, Fang Z, Liao P, Zhou X, Xiong J, Zeng S, et al. Cancer-mutated ribosome protein L22 (RPL22/eL22) suppresses cancer cell survival by blocking p53-MDM2 circuit. Oncotarget. 2017;8:90651-90661 pubmed publisher
    ..Also, RPL22/eL22 formed a complex with MDM2/RPL5/uL18/RPL11/uL5 and synergized with RPL11/uL5 to activate p53...
  82. Lin E, Lin S, Lin A. The participation of 5S rRNA in the co-translational formation of a eukaryotic 5S ribonucleoprotein complex. Nucleic Acids Res. 2001;29:2510-6 pubmed
    ..This suggests that the 5S rRNP complex enhances nuclear transport of L5. We propose that 5S rRNA plays a chaperone-like role in folding of the nascent chain of L5 and directs L5 into a 5S rRNP complex for nuclear entry. ..
  83. Gilkes D, Chen L, Chen J. MDMX regulation of p53 response to ribosomal stress. EMBO J. 2006;25:5614-25 pubmed
    ..MDMX overexpression does not accelerate tumor growth but increases resistance to 5-FU treatment in vivo. Therefore, MDMX is an important regulator of p53 response to ribosomal stress and RNA-targeting chemotherapy agents. ..
  84. Sloan K, Bohnsack M, Watkins N. The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. Cell Rep. 2013;5:237-47 pubmed publisher
    ..defects result in p53 activation via repression of mouse double minute 2 (MDM2) homolog by the ribosomal proteins RPL5 and RPL11...
  85. Guerra B, Issinger O. p53 and the ribosomal protein L5 participate in high molecular mass complex formation with protein kinase CK2 in murine teratocarcinoma cell line F9 after serum stimulation and cisplatin treatment. FEBS Lett. 1998;434:115-20 pubmed
    ..This is the first evidence that, under physiological conditions, protein kinase CK2 does not exist solely as a heterotetramer, but predominantly in association with other proteins. ..
  86. Alcina A, Fernandez O, Gonzalez J, Catalá Rabasa A, Fedetz M, Ndagire D, et al. Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis. Eur J Hum Genet. 2010;18:827-31 pubmed publisher
    ..Twenty-one SNPs positively associated with MS were located at the GFI-EVI5-RPL5-FAM69A locus...
  87. Qu L, Nicoloso M, Michot B, Azum M, Caizergues Ferrer M, Renalier M, et al. U21, a novel small nucleolar RNA with a 13 nt. complementarity to 28S rRNA, is encoded in an intron of ribosomal protein L5 gene in chicken and mammals. Nucleic Acids Res. 1994;22:4073-81 pubmed
    ..Accordingly, this complementarity, which overlaps the complementarity of 28S rRNA to another snoRNA, U18, could reflect an important role of U21 snoRNA in the biogenesis of large ribosomal subunit. ..
  88. Bortoluzzi S, d Alessi F, Romualdi C, Danieli G. Differential expression of genes coding for ribosomal proteins in different human tissues. Bioinformatics. 2001;17:1152-7 pubmed
    ..bio.unipd.it/GETProfiles/). danieli@bio.unipd.it ..
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    ..disorders (GATA2, RUNX1), telomeropathies (TERC, TERT, RTEL1), ribosome disorders (SBDS, DNAJC21, RPL5), and DNA repair deficiency (LIG4) Many patients had an atypical presentation, and the mutated gene was ..
  90. Mingot J, Kostka S, Kraft R, Hartmann E, Gorlich D. Importin 13: a novel mediator of nuclear import and export. EMBO J. 2001;20:3685-94 pubmed
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    ..Our data demonstrate a unique c-Myb-Hep27-Mdm2-p53 mitochondria-to-nucleus signaling pathway that may have functional significance for ER-positive breast cancers. ..