Gene Symbol: RPL19
Description: ribosomal protein L19
Alias: L19, 60S ribosomal protein L19, large ribosomal subunit protein eL19
Species: human
Products:     RPL19

Top Publications

  1. Bee A, Ke Y, Forootan S, Lin K, Beesley C, Forrest S, et al. Ribosomal protein l19 is a prognostic marker for human prostate cancer. Clin Cancer Res. 2006;12:2061-5 pubmed
    ..benign (PNT2) and malignant (PC3M) human prostate cell lines identified the gene encoding ribosomal protein L19 (RPL19) to be overexpressed in the malignant cells...
  2. Kuroda K, Takenoyama M, Baba T, Shigematsu Y, Shiota H, Ichiki Y, et al. Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma. Cancer Sci. 2010;101:46-53 pubmed publisher
    ..gene was identified using the cDNA expression cloning technique, which encodes ribosomal protein L19 (RPL19). Finally, a 9 mer antigenic peptide was identified by means of construction of mini-genes...
  3. Chan Y, Lin A, McNally J, Peleg D, Meyuhas O, Wool I. The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein. J Biol Chem. 1987;262:1111-5 pubmed
    The covalent structure of rat ribosomal protein L19 was inferred from the sequence of nucleotides in a recombinant cDNA and confirmed from the sequence of amino acids in a portion of the protein...
  4. Henry J, Coggin D, King C. High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2. Cancer Res. 1993;53:1403-8 pubmed
    ..One complementary DNA was studied in detail. The mRNA encoding the ribosomal protein L19 (1.9 kilobases) was more abundant in breast cancer samples that express high levels of erbB-2 (P < 6 x 10(-7))...
  5. Jia Y, Shi L, Yun F, Liu X, Chen Y, Wang M, et al. Transcriptome sequencing profiles reveal lncRNAs may involve in breast cancer (ER/PR positive type) by interaction with RAS associated genes. Pathol Res Pract. 2019;: pubmed publisher
    ..7 and NEAT1, and the highest expressing mRNAs were RPL19, SCGB2A2, FTL and TMSB4 × ...
  6. Vitorino Carvalho A, Courousse N, Crochet S, Coustham V. Identification of Reference Genes for Quantitative Gene Expression Studies in Three Tissues of Japanese Quail. Genes (Basel). 2019;10: pubmed publisher
    ..we investigated 10 putative reference genes (ACTB, GAPDH, PGK1, RPS7, RPS8, RPL19, RPL32, SDHA, TBP and YWHAZ) in three different female and male quail tissues (..
  7. Petrova E, Gracias S, Beauclair G, Tangy F, Jouvenet N. Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen. Viruses. 2019;11: pubmed publisher
    ..silencing approaches, we validated the role of four candidates in YFV and WNV replication: ribosomal protein L19 (RPL19), ribosomal protein S3 (RPS3), DDOST and importin 9 (IPO9)...
  8. Chari R, Lonergan K, Pikor L, Coe B, Zhu C, Chan T, et al. A sequence-based approach to identify reference genes for gene expression analysis. BMC Med Genomics. 2010;3:32 pubmed publisher
    ..Our analyses found NDUFA1, RPL19, RAB5C, and RPS18 to occupy the top ranking positions among 15 suitable reference genes optimal for normalization ..
  9. Roura M, Catalá M, Soto Heras S, Hammami S, Izquierdo D, Fouladi Nashta A, et al. Linoleic (LA) and linolenic (ALA) acid concentrations in follicular fluid of prepubertal goats and their effect on oocyte in vitro maturation and embryo development. Reprod Fertil Dev. 2018;30:286-296 pubmed publisher
    ..to the IVM medium on embryo development, mitochondrial activity, ATP concentration and relative gene expression (RPL19, ribosomal protein L19; SLC2A1, facilitated glucose transporter 1; ATF4, activating transcription factor 4; GPX1, ..

More Information


  1. You Y, Xie M, Vasseur L, You M. Selecting and Validating Reference Genes for Quantitative Real-time PCR in <i>Plutella xylostella</i> (L.). Genome. 2018;: pubmed publisher
    ..lt;i>hsp90</i>, <i>ndpk</i>, <i>rpl13a</i>, <i>rpl18</i>, <i>rpl19</i>, <i>rpl32</i>, <i>rpl4</i>, <i>rpl8</i>, <i>rps13</i>, &..
  2. Broustas C, Harken A, Garty G, Amundson S. Identification of differentially expressed genes and pathways in mice exposed to mixed field neutron/photon radiation. BMC Genomics. 2018;19:504 pubmed publisher
    ..g. Eif2ak4, Eif3f), as well as 40S and 60S ribosomal subunits (e.g. Rsp19, Rpl19, Rpl27). Many of the differentially downregulated ribosomal genes (e.g...
  3. de Almeida Bizzo J, Alves L, Castro F, Garcia J, Goldenberg S, Cruz A. Characterization of the pattern of ribosomal protein L19 production during the lifecycle of Leishmania spp. Exp Parasitol. 2014;147:60-6 pubmed publisher
    ..showed that the transcript of a putative L19 ribosomal protein (RPL19) was most abundant at the amastigote stage...
  4. Bansal S, Gupta N, Sankhwar S, Rajender S. Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis. PLoS ONE. 2015;10:e0127007 pubmed publisher
    ..Some transcripts were specific to the normozoospermic group (up-regulated: CAPNS1, FAM153C, ARF1, CFL1, RPL19, USP22; down-regulated: ZNF90, SMNDC1, c14orf126, HNRNPK), while some were specific to the asthenozoospermic group ..
  5. Schulze F, Malhan D, El Khassawna T, Heiss C, Seckinger A, Hose D, et al. A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model. BMC Genomics. 2017;18:975 pubmed publisher
    ..RefFinder was used to rank the candidate genes. We identified B2M, GAPDH, RPL19 and YWHAZ as the best combination of reference genes for normalization of RT-qPCR results for transcriptional ..
  6. McIntosh C, Baird J, Zinser E, Woods D, Campbell E, Bowman A. Reference gene selection and RNA preservation protocol in the cat flea, Ctenocephalides felis, for gene expression studies. Parasitology. 2016;143:1532-42 pubmed publisher
    ..Glyceraldehyde 3 phosphate dehydrogenase (GAPDH), 60S ribosomal protein L19 (RPL19) and elongation factor-1α (Ef) were ranked highly in all stability comparisons, thus are ..
  7. Gütling H, Bionaz M, Sloboda D, Ehrlich L, Braun F, Gramzow A, et al. The importance of selecting the right internal control gene to study the effects of antenatal glucocorticoid administration in human placenta. Placenta. 2016;44:19-22 pubmed publisher
    ..The algorithms revealed that a reliable normalization was achieved using the geometrical mean of PPIA, RPL19, HMBS and SDHA...
  8. Tsubota S, Phillips A. Drosophila Enhancer of Rudimentary Homolog, ERH, Is a Binding Partner of RPS3, RPL19, and DDIT4, Suggesting a Mechanism for the Nuclear Localization of ERH. Mol Biol Int. 2016;2016:8371819 pubmed
    ..Through yeast two-hybrid screens, three new binding partners of ERH, RPS3, RPL19, and DDIT4, were identified. RPS3 was isolated from both human and Drosophila screens...
  9. Crookenden M, Walker C, Kuhn Sherlock B, Murray A, Dukkipati V, Heiser A, et al. Technical note: Evaluation of endogenous control gene expression in bovine neutrophils by reverse-transcription quantitative PCR using microfluidics gene expression arrays. J Dairy Sci. 2017;100:6763-6771 pubmed publisher
    ..The selected genes included ACTB, B2M, G6PD, GAPDH, GCH1, GOLGA5, OSBPL2, PGK1, RPL13A, RPL19, RPS9, SDHA, SMUG1, SNRPA, TBP, UXT, and YWHAZ...
  10. Lenart J, Kogut K, Salinska E. Lateralization of housekeeping genes in the brain of one-day old chicks. Gene Expr Patterns. 2017;25-26:85-91 pubmed publisher
    ..For memory process investigations using tasks in one-day old chicks the most effective reference genes for the left hemisphere were HMBS and SDHA, and for the right hemisphere the most effective was RPL19.
  11. Hong M, Kim H, Kim I. Ribosomal protein L19 overexpression activates the unfolded protein response and sensitizes MCF7 breast cancer cells to endoplasmic reticulum stress-induced cell death. Biochem Biophys Res Commun. 2014;450:673-8 pubmed publisher
    ..Overexpression of RPL19 sensitized MCF7 cells to endoplasmic reticulum stress-induced cell death...
  12. Davies B, Fried M. The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter region. Genomics. 1995;25:372-80 pubmed
    The intron-containing genes encoding rat and human ribosomal protein L19 (RPL19) have been cloned. The DNA sequences of the entire rat RPL19 gene and the 5' end of the human RPL19 gene have been determined...
  13. Bee A, Brewer D, Beesley C, Dodson A, Forootan S, Dickinson T, et al. siRNA knockdown of ribosomal protein gene RPL19 abrogates the aggressive phenotype of human prostate cancer. PLoS ONE. 2011;6:e22672 pubmed publisher
    We provide novel functional data that posttranscriptional silencing of gene RPL19 using RNAi not only abrogates the malignant phenotype of PC-3M prostate cancer cells but is selective with respect to transcription and translation of ..
  14. Albanese C, Suttapitugsakul S, Perati S, McGown L. A genome-inspired, reverse selection approach to aptamer discovery. Talanta. 2018;177:150-156 pubmed publisher
    ..of nucleolin by all three of the oligonucleotides in BT474 and MCF7 cells, and also of ribosomal protein L19 (RPL19) in BT474 cells...
  15. Czabanka M, Parmaksiz G, Bayerl S, Nieminen M, Trachsel E, Menssen H, et al. Microvascular biodistribution of L19-SIP in angiogenesis targeting strategies. Eur J Cancer. 2011;47:1276-84 pubmed publisher
    Various strategies using L19-mediated fibronectin targeting have become useful clinical tools in anti-tumour therapy and diagnostics...
  16. Lederer C, Torrisi A, Pantelidou M, Santama N, Cavallaro S. Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. BMC Genomics. 2007;8:26 pubmed
  17. Wagner K, Schulz P, Scholz A, Wiedenmann B, Menrad A. The targeted immunocytokine L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer. Clin Cancer Res. 2008;14:4951-60 pubmed publisher
    ..We therefore investigated the therapeutic efficacy of the targeted immunocytokine L19-Interleukin-2 (L19-IL2), consisting of the human single-chain Fv antibody L19, which is highly specific for the ..
  18. Deprez P, Sempoux C, De Saeger C, Rahier J, Mainguet P, Pauwels S, et al. Expression of cholecystokinin in the duodenum of patients with coeliac disease: respective role of atrophy and lymphocytic infiltration. Clin Sci (Lond). 2002;103:171-7 pubmed
    ..measured with a semi-quantitative reverse transcriptase-PCR method using specific CCK and ribosomal protein L19 (RPL19) primers. CCK tissue concentration and CCK mRNA were significantly reduced in patients with atrophic mucosa [12...
  19. Vanni S, Moda F, Zattoni M, Bistaffa E, De Cecco E, Rossi M, et al. Differential overexpression of SERPINA3 in human prion diseases. Sci Rep. 2017;7:15637 pubmed publisher
    ..Real Time-quantitative PCR was performed for SERPINA3 transcript, and ACTB, RPL19, GAPDH and B2M were used as reference genes...
  20. Kumabe T, Sohma Y, Yamamoto T. Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19. Nucleic Acids Res. 1992;20:2598 pubmed
  21. Feo S, Davies B, Fried M. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. Genomics. 1992;13:201-7 pubmed
    ..We have used this technique to identify the intron-containing PCR products of seven human rp genes (rpL19, rpL30, rpL35a, rpL36a, rpS6, rpS11, rpS17) and to map their chromosomal locations...