RPL11

Summary

Gene Symbol: RPL11
Description: ribosomal protein L11
Alias: DBA7, GIG34, L11, uL5, 60S ribosomal protein L11, CLL-associated antigen KW-12, cell growth-inhibiting protein 34, large ribosomal subunit protein uL5
Species: human
Products:     RPL11

Top Publications

  1. Dai M, Lu H. Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. J Biol Chem. 2004;279:44475-82 pubmed
    The oncoprotein MDM2 associates with ribosomal proteins L5, L11, and L23. Both L11 and L23 have been shown to activate p53 by inhibiting MDM2-mediated p53 suppression. Here we have shown that L5 also activates p53...
  2. Dai M, Shi D, Jin Y, Sun X, Zhang Y, Grossman S, et al. Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism. J Biol Chem. 2006;281:24304-13 pubmed
    ..The ribosomal proteins L5, L11, and L23 can block this loop by inhibiting MDM2-mediated p53 ubiquitination and degradation in response to ..
  3. Horn H, Vousden K. Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway. Oncogene. 2008;27:5774-84 pubmed publisher
    ..These include the alternate reading frame (ARF) proteins and the ribosomal proteins L5 and L11. We found that when overexpressed alone, L11 is much less potent in inhibiting MDM2 than p14(ARF)...
  4. Cmejla R, Cmejlova J, Handrkova H, Petrak J, Petrtylova K, Mihal V, et al. Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond-Blackfan anemia. Hum Mutat. 2009;30:321-7 pubmed publisher
    ..Recently, mutations in RPL5, RPL11, and RPL35a of the large ribosomal subunit have also been reported in several DBA patients...
  5. Jin A, Itahana K, O KEEFE K, Zhang Y. Inhibition of HDM2 and activation of p53 by ribosomal protein L23. Mol Cell Biol. 2004;24:7669-80 pubmed
    ..The interaction involves the central acidic domain of HDM2 and an N-terminal domain of L23. L23 and L11, another HDM2-interacting ribosomal protein, can simultaneously yet distinctly interact with HDM2 together to form ..
  6. Challagundla K, Sun X, Zhang X, Devine T, Zhang Q, Sears R, et al. Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. Mol Cell Biol. 2011;31:4007-21 pubmed publisher
    ..Here, we show that ribosomal protein L11 regulates c-myc mRNA turnover...
  7. Mahata B, Sundqvist A, Xirodimas D. Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner. Oncogene. 2012;31:3060-71 pubmed publisher
    ..We show that the RPL11 is rapidly but transiently recruited at promoter sites of p53-regulated genes upon nucleolar stress induced by ..
  8. Bursac S, Brdovcak M, Pfannkuchen M, Orsolic I, Golomb L, Zhu Y, et al. Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proc Natl Acad Sci U S A. 2012;109:20467-72 pubmed publisher
    ..The ability of ribosomal proteins L5, L11, L23, L26, or S7 to bind Mdm2 and inhibit its ubiquitin ligase activity has been suggested as a critical step in ..
  9. Bhat K, Itahana K, Jin A, Zhang Y. Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation. EMBO J. 2004;23:2402-12 pubmed
    The ribosomal protein L11 binds to and suppresses the E3 ligase function of HDM2, thus activating p53. Despite being abundant as a component of the 60S large ribosomal subunit, L11 does not induce p53 under normal growth conditions...

More Information

Publications109 found, 100 shown here

  1. Dai M, Sun X, Lu H. Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2. Mol Cell Biol. 2008;28:4365-76 pubmed publisher
    ..These effects require the ribosomal proteins L5 and L11, since the depletion of NS enhanced their interactions with MDM2 and the knockdown of L5 or L11 abrogated the NS ..
  2. Fumagalli S, Di Cara A, Neb Gulati A, Natt F, Schwemberger S, Hall J, et al. Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction. Nat Cell Biol. 2009;11:501-8 pubmed publisher
    ..of biogenesis of 40S ribosomes had no effect on nucleolar integrity, although p53 induction was mediated by rpL11, leading to the finding that the cell selectively upregulates the translation of mRNAs with a polypyrimidine tract ..
  3. Gazda H, Sheen M, Vlachos A, Choesmel V, O Donohue M, Schneider H, et al. Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. Am J Hum Genet. 2008;83:769-80 pubmed publisher
    ..Here, we report the second known mutation in RPS17 and probable pathogenic mutations in three more RP genes, RPL5, RPL11, and RPS7...
  4. Dai M, Arnold H, Sun X, Sears R, Lu H. Inhibition of c-Myc activity by ribosomal protein L11. EMBO J. 2007;26:3332-45 pubmed
    ..Hence, c-Myc activity and ribosomal biogenesis must be regulated in cells. Here, we show that ribosomal protein L11, a component of the large subunit of the ribosome, controls c-Myc function through a negative feedback mechanism...
  5. Hölzel M, Orban M, Hochstatter J, Rohrmoser M, Harasim T, Malamoussi A, et al. Defects in 18 S or 28 S rRNA processing activate the p53 pathway. J Biol Chem. 2010;285:6364-70 pubmed publisher
    ..Interestingly, accumulation of p53 after hUTP18 knock down required the ribosomal protein L11. Therefore, cells survey the maturation of the small and large ribosomal subunits by separate molecular routes, ..
  6. Sun X, Wang Y, Xirodimas D, Dai M. Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation. J Biol Chem. 2010;285:25812-21 pubmed publisher
    ..Multiple ribosomal proteins, including L5, L11, L23, and S7, have been shown to bind to and inhibit MDM2, leading to p53 activation...
  7. Dai M, Challagundla K, Sun X, Palam L, Zeng S, Wek R, et al. Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF. J Biol Chem. 2012;287:17120-9 pubmed publisher
    The ARF tumor suppressor protein activates p53 in response to oncogenic stress, whereas ribosomal protein L11 induces p53 following ribosomal stress...
  8. Zhang Y, Wolf G, Bhat K, Jin A, Allio T, Burkhart W, et al. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol. 2003;23:8902-12 pubmed
    ..Here we report that the human homologue of MDM2, HDM2, binds to ribosomal protein L11. L11 binds a central region in HDM2 that is distinct from the ARF binding site...
  9. Chen D, Zhang Z, Li M, Wang W, Li Y, Rayburn E, et al. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene. 2007;26:5029-37 pubmed
    ..The identification of S7 as a novel MDM2-interacting partner contributes to elucidation of the complex regulation of the MDM2-p53 interaction and has implications in cancer prevention and therapy. ..
  10. Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, et al. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med. 2011;17:944-51 pubmed publisher
    ..Pict1-deficient cells accumulated p53, owing to impaired Mdm2 function. Pict1 binds Rpl11, and Rpl11 is released from nucleoli in the absence of Pict1...
  11. Sun X, Dai M, Lu H. 5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction. J Biol Chem. 2007;282:8052-9 pubmed
    ..5-FU treatment increased the fraction of ribosome-free L5, L11, and L23 ribosomal proteins and their interaction with MDM2, leading to p53 activation and G1/S arrest...
  12. Xirodimas D, Sundqvist A, Nakamura A, Shen L, Botting C, Hay R. Ribosomal proteins are targets for the NEDD8 pathway. EMBO Rep. 2008;9:280-6 pubmed publisher
    ..We further show that the lack of NEDDylation in cells causes ribosomal protein instability. Our studies identify a novel and specific role of the NEDD8 pathway in protecting a subset of ribosomal proteins from destabilization. ..
  13. Lohrum M, Ludwig R, Kubbutat M, Hanlon M, Vousden K. Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell. 2003;3:577-87 pubmed
    ..In this report, we show that the ribosomal protein L11 can interact with HDM2 and inhibit HDM2 function, thus leading to the stabilization and activation of p53...
  14. Sundqvist A, Liu G, Mirsaliotis A, Xirodimas D. Regulation of nucleolar signalling to p53 through NEDDylation of L11. EMBO Rep. 2009;10:1132-9 pubmed publisher
    ..Here, we identify NEDD8 as a crucial regulator of L11 RP signalling to p53...
  15. Quarello P, Garelli E, Carando A, Brusco A, Calabrese R, Dufour C, et al. Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations. Haematologica. 2010;95:206-13 pubmed publisher
    ..Two new genes (RPL5, RPL11), encoding for ribosomal proteins of the large subunit, have been reported to be involved in a considerable ..
  16. Dai M, Zeng S, Jin Y, Sun X, David L, Lu H. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol. 2004;24:7654-68 pubmed
    ..These results reveal that L23 is another regulator of the p53-MDM2 feedback regulation. ..
  17. Gilkes D, Chen L, Chen J. MDMX regulation of p53 response to ribosomal stress. EMBO J. 2006;25:5614-25 pubmed
    ..MDMX overexpression does not accelerate tumor growth but increases resistance to 5-FU treatment in vivo. Therefore, MDMX is an important regulator of p53 response to ribosomal stress and RNA-targeting chemotherapy agents. ..
  18. Sloan K, Bohnsack M, Watkins N. The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. Cell Rep. 2013;5:237-47 pubmed publisher
    ..result in p53 activation via repression of mouse double minute 2 (MDM2) homolog by the ribosomal proteins RPL5 and RPL11. Here, we report that RPL5 and RPL11 regulate p53 from the context of a ribosomal subcomplex, the 5S ..
  19. Zhang Q, Zhou X, Wu R, Mosley A, Zeng S, Xing Z, et al. The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress. elife. 2014;3: pubmed publisher
    ..genetic alteration that disrupts ribosomal biogenesis, and mediated by several ribosomal proteins (RPs), such as RPL11 and RPL5, which inhibit MDM2 and activate p53...
  20. Dong Z, Zhu C, Zhan Q, Jiang W. The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells. Oncotarget. 2017;8:13240-13252 pubmed publisher
    ..Perturbation of RRP15 induces nucleolar stress that activates RPL5/RPL11/5S rRNA (RP)-Mdm2-p53 axis checkpoint response and arrests cells at G1-G1/S in p53-proficient non-transformed RPE1 ..
  21. Nishimura K, Kumazawa T, Kuroda T, Katagiri N, Tsuchiya M, Goto N, et al. Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation. Cell Rep. 2015;10:1310-23 pubmed publisher
    The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation under ribotoxic stress...
  22. Calviño F, Kharde S, Ori A, Hendricks A, Wild K, Kressler D, et al. Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site. Nat Commun. 2015;6:6510 pubmed publisher
    During 60S biogenesis, mature 5S RNP consisting of 5S RNA, RpL5 and RpL11, assembles into a pre-60S particle, where docking relies on RpL11 interacting with helix 84 (H84) of the 25S RNA...
  23. Waku T, Nakajima Y, Yokoyama W, Nomura N, Kako K, Kobayashi A, et al. NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner. J Cell Sci. 2016;129:2382-93 pubmed publisher
    ..NML also contributes to 60S ribosomal subunit formation. Intriguingly, NML depletion increases 60S ribosomal protein L11 (RPL11) levels in the ribosome-free fraction and protein levels of p53 through an RPL11-MDM2 complex, ..
  24. Liu S, Tackmann N, Yang J, Zhang Y. Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis. Oncogene. 2017;36:1374-1383 pubmed publisher
    ..In lymphoma, both p19ARF and ribosomal proteins RPL11 and RPL5 respond to c-MYC activation to induce p53...
  25. Uchi R, Kogo R, Kawahara K, Sudo T, Yokobori T, Eguchi H, et al. PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression. Br J Cancer. 2013;109:2199-206 pubmed publisher
    ..known as GLTSCR2) is a novel regulator of the MDM2-TP53 pathway via its interaction with the ribosomal protein RPL11 in the nucleolus. However, the clinical significance of PICT1 in gastric cancer remains unknown...
  26. Pan W, Tsai H, Wang S, Hsiao M, Wu P, Tsai M. The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression. RNA Biol. 2015;12:255-67 pubmed publisher
    ..NIFK inhibits cell proliferation through a reversible p53-dependent G1 arrest, possibly by induction of the RPL5/RPL11-mediated nucleolar stress. Mechanistically it is the consequence of impaired maturation of 28S and 5...
  27. Asano N, Kato K, Nakamura A, Komoda K, Tanaka I, Yao M. Structural and functional analysis of the Rpf2-Rrs1 complex in ribosome biogenesis. Nucleic Acids Res. 2015;43:4746-57 pubmed publisher
    ..These proteins are necessary for the recruitment of three ribosomal components (5S ribosomal RNA [rRNA], RpL5 and RpL11) to the 90S ribosome precursor and subsequent 27SB pre-rRNA processing...
  28. Swindell W, Remmer H, Sarkar M, Xing X, Barnes D, Wolterink L, et al. Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance. Genome Med. 2015;7:86 pubmed publisher
    ..translation proteins were elevated within lesions, without a corresponding shift in mRNA expression (RPL3, RPS8, RPL11)...
  29. Watanabe S, Fujiyama H, Takafuji T, Kayama K, Matsumoto M, Nakayama K, et al. GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system. J Cell Sci. 2018;131: pubmed publisher
    ..GRWD1 acts as a tumor-promoting factor by downregulating p53 (also known as TP53) via the RPL11-MDM2-p53 axis...
  30. Jung J, Liao J, Zhang Q, Zeng S, Nguyen D, Hao Q, et al. Inauhzin(c) inactivates c-Myc independently of p53. Cancer Biol Ther. 2015;16:412-9 pubmed publisher
    ..was impaired by disrupting the targeting of c-Myc mRNA by miRNAs via knockdown of ribosomal protein (RP) L5, RPL11, or Ago2, a subunit of RISC complex, indicating that INZ(c) targets c-Myc via miRNA pathways...
  31. Castle C, Cassimere E, Denicourt C. LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis. Mol Biol Cell. 2012;23:716-28 pubmed publisher
    ..Taken together, our data identify a novel mammalian complex required for 60S ribosomal subunit synthesis, providing further insight into the intricate, yet poorly described, process of ribosome biogenesis in higher eukaryotes. ..
  32. Morgado Palacin L, Varetti G, Llanos S, Gómez López G, Martinez D, Serrano M. Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis. Cell Rep. 2015;13:712-722 pubmed publisher
    ..is characterized by anemia and cancer susceptibility and is caused by mutations in ribosomal genes, including RPL11. Here, we report that Rpl11-heterozygous mouse embryos are not viable and that Rpl11 homozygous deletion in adult ..
  33. Liu S, Kim T, Franklin D, Zhang Y. Protection against High-Fat-Diet-Induced Obesity in MDM2C305F Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure. Cell Rep. 2017;18:1005-1018 pubmed publisher
    The RPL11-MDM2 interaction constitutes a p53 signaling pathway activated by deregulated ribosomal biosynthesis in response to stress...
  34. Wang Y, DiMario P. Loss of Drosophila nucleostemin 2 (NS2) blocks nucleolar release of the 60S subunit leading to ribosome stress. Chromosoma. 2017;126:375-388 pubmed publisher
    ..depletion of NS2 in midgut cells blocked the release of the 60S subunit as detected by the accumulation of GFP-RpL11 within nucleoli, and this likely led to the general loss of 60S subunits as shown by immunoblot analyses of RpL23a ..
  35. Cao P, Yang A, Wang R, Xia X, Zhai Y, Li Y, et al. Germline Duplication of SNORA18L5 Increases Risk for HBV-related Hepatocellular Carcinoma by Altering Localization of Ribosomal Proteins and Decreasing Levels of p53. Gastroenterology. 2018;155:542-556 pubmed publisher
    ..biogenesis, increasing levels of mature 18S and 28S ribosomal RNAs and causing the ribosomal proteins RPL5 and RPL11 to stay in the nucleolus, which kept them from binding to MDM2...
  36. Deisenroth C, Thorner A, Enomoto T, Perou C, Zhang Y. Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. Mol Cell Biol. 2010;30:3981-93 pubmed publisher
    ..Our data demonstrate a unique c-Myb-Hep27-Mdm2-p53 mitochondria-to-nucleus signaling pathway that may have functional significance for ER-positive breast cancers. ..
  37. Zhou X, Hao Q, Zhang Q, Liao J, Ke J, Liao P, et al. Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition. Cell Death Differ. 2015;22:755-66 pubmed publisher
    ..Herein, we report that RPL5 and RPL11 can also enhance the transcriptional activity of a p53 homolog TAp73, but through a distinct mechanism...
  38. Juli G, Gismondi A, Monteleone V, Caldarola S, Iadevaia V, Aspesi A, et al. Depletion of ribosomal protein S19 causes a reduction of rRNA synthesis. Sci Rep. 2016;6:35026 pubmed publisher
    ..A similar effect is observed upon depletion of RPS6 or RPL11. The deficiency of RPS19 does not alter the stability of rRNA, but instead leads to an inhibition of RNA ..
  39. Meng X, Tackmann N, Liu S, Yang J, Dong J, Wu C, et al. RPL23 Links Oncogenic RAS Signaling to p53-Mediated Tumor Suppression. Cancer Res. 2016;76:5030-9 pubmed publisher
    ..pathway is a broad antioncogenic mechanism, we crossed mice bearing an MDM2(C305F) mutation, which disrupts RPL11 binding to MDM2, with mice expressing an oncogenic Hras(G12V) transgene...
  40. Zhang Z, Jia H, Zhang Q, Wan Y, Song B, Jia Q, et al. Transcriptome analysis of Rpl11-deficient zebrafish model of Diamond-Blackfan Anemia. Genom Data. 2014;2:173-5 pubmed publisher
    To comprehensively reflect the roles of Rpl11 on the transcriptome of zebrafish model of Diamond-Blackfan Anemia (DBA), we performed whole-genome transcriptome sequencing on the Illumina Hi-Seq 2000 sequencing platform...
  41. Pelava A, Schneider C, Watkins N. The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and disease. Biochem Soc Trans. 2016;44:1086-90 pubmed publisher
    ..The ribosomal assembly intermediate 5S RNP (ribonucleoprotein particle), containing RPL5, RPL11 and the 5S rRNA, accumulates when ribosome biogenesis is blocked...
  42. Graphodatsky A, Vorobieva N, Filipenko M, Voronina E, Frengen E, Prydz H. Assignment of the L11 ribosomal protein gene (RPL11) to human chromosome 1p36.1-->p35 by in situ hybridization. Cytogenet Cell Genet. 1999;84:97-8 pubmed
  43. Madru C, Lebaron S, Blaud M, Delbos L, Pipoli J, Pasmant E, et al. Chaperoning 5S RNA assembly. Genes Dev. 2015;29:1432-46 pubmed publisher
    ..III and is assembled into the 5S ribonucleoprotein particle (RNP), containing ribosomal proteins Rpl5/uL18 and Rpl11/uL5, prior to its incorporation into preribosomes...
  44. Chakraborty A, Uechi T, Higa S, Torihara H, Kenmochi N. Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response. PLoS ONE. 2009;4:e4152 pubmed publisher
    ..the effects of the deletion of L11 and its physiological relevance to p53 activity, we knocked down the rpl11 gene in zebrafish and analyzed the p53 response...
  45. Cao B, Fang Z, Liao P, Zhou X, Xiong J, Zeng S, et al. Cancer-mutated ribosome protein L22 (RPL22/eL22) suppresses cancer cell survival by blocking p53-MDM2 circuit. Oncotarget. 2017;8:90651-90661 pubmed publisher
    ..Also, RPL22/eL22 formed a complex with MDM2/RPL5/uL18/RPL11/uL5 and synergized with RPL11/uL5 to activate p53...
  46. Fang Z, Cao B, Liao J, Deng J, Plummer K, Liao P, et al. SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer. elife. 2018;7: pubmed publisher
    ..SPIN1 deficiency increases ribosome-free uL18 and uL5 (human RPL11), which are required for SPIN1 depletion-induced p53 activation...
  47. Huang Z, Bian G, Xi Z, Xie X. Genes important for survival or reproduction in Varroa destructor identified by RNAi. Insect Sci. 2019;26:68-75 pubmed publisher
    ..Double-stranded RNA (dsRNA) of six candidate genes (Da, Pros26S, RpL8, RpL11, RpP0 and RpS13) were synthesized and each injected into Varroa mites, then mite survival and reproduction were ..
  48. Devlin J, Hannan K, Hein N, Cullinane C, Kusnadi E, Ng P, et al. Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma. Cancer Discov. 2016;6:59-70 pubmed publisher
    ..induced expression of the proapoptotic protein BMF that was independent of p53 and reduced expression of RPL11 and RPL5...
  49. Nicolas E, Parisot P, Pinto Monteiro C, de Walque R, De Vleeschouwer C, Lafontaine D. Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress. Nat Commun. 2016;7:11390 pubmed publisher
    ..Remarkably, we find that uL5 (formerly RPL11) and uL18 (RPL5) are the strongest contributors to nucleolar integrity...
  50. Fancello L, Kampen K, Hofman I, Verbeeck J, De Keersmaecker K. The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types. Oncotarget. 2017;8:14462-14478 pubmed publisher
    ..number data of respectively 4926 and 7322 samples from 16 cancer types and identified six altered genes (RPL5, RPL11, RPL23A, RPS5, RPS20 and RPSA)...
  51. Sabharwal A, Sharma D, Vellarikkal S, Jayarajan R, Verma A, Senthivel V, et al. Organellar transcriptome sequencing reveals mitochondrial localization of nuclear encoded transcripts. Mitochondrion. 2019;46:59-68 pubmed publisher
    ..We experimentally demonstrated that the transcript encoding the nuclear encoded ribosomal protein 11 (Rpl11) localizes to the mitochondria...
  52. Neben C, Tuzon C, Mao X, Lay F, Merrill A. FGFR2 mutations in bent bone dysplasia syndrome activate nucleolar stress and perturb cell fate determination. Hum Mol Genet. 2017;26:3253-3270 pubmed publisher
    ..rDNA induced by the BBDS mutations direct nucleolar disorganization, alter ribosome biogenesis, and activate the Rpl11-Mdm2-p53 nucleolar stress response pathway...
  53. Herrero Ã, Planelló R, Morcillo G. The ribosome biogenesis pathway as an early target of benzyl butyl phthalate (BBP) toxicity in Chironomus riparius larvae. Chemosphere. 2016;144:1874-84 pubmed publisher
    ..internal transcribed spacer 2, ITS2) and variations in the expression profile of ribosomal protein genes (rpL4, rpL11, and rpL13) after acute 24-h and 48-h exposures to a wide range of BBP doses...
  54. Dai M, Sun X, Lu H. Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression. J Biol Chem. 2010;285:12587-94 pubmed publisher
    ..We previously found that ribosomal protein L11 inhibits c-Myc activity by blocking the recruitment of its co-activator transformation/transcription domain-..
  55. Mazzoleni M, Figuet S, Martin Laffon J, Mininno M, Gilgen A, Leroux M, et al. Dual Targeting of the Protein Methyltransferase PrmA Contributes to Both Chloroplastic and Mitochondrial Ribosomal Protein L11 Methylation in Arabidopsis. Plant Cell Physiol. 2015;56:1697-710 pubmed publisher
    ..The bacterial protein methyltransferase PrmA catalyzes the trimethylation of ribosomal protein L11 (RPL11) at three distinct sites. The role of these modifications is still unknown...
  56. Wandrey F, Montellese C, Koos K, Badertscher L, Bammert L, Cook A, et al. The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology. Mol Cell Biol. 2015;35:3491-503 pubmed publisher
    ..by induction of the cyclin-dependent kinase inhibitor p21/CIP1, which can be counteracted by depletion of RPL11. Together, these data indicate that NF45 and NF90 are novel higher-eukaryote-specific factors required for the ..
  57. Mishin V, Filipenko M, Muravlev A, Karpova G, Mertvetsov N. [Cloning and determination of the primary structure of DNA complementary to the mRNA of human ribosomal protein L11]. Bioorg Khim. 1995;21:158-60 pubmed
    A polymerase chain reaction strategy was employed to isolate cDNA encoding L11 human ribosomal protein...
  58. He X, Li Y, Dai M, Sun X. Ribosomal protein L4 is a novel regulator of the MDM2-p53 loop. Oncotarget. 2016;7:16217-26 pubmed publisher
    ..Interestingly, overexpression of RPL4 promotes the binding of MDM2 to RPL5 and RPL11 and forms a complex with RPL5, RPL11 and MDM2 in cells...
  59. Voronina E, Kolokol tsova T, Slyn ko N, Nechaev E, Filipenko M. [Transcription factor YY1 participates in activation transcription of the human ribosomal protein L11 gene]. Mol Biol (Mosk). 2008;42:110-6 pubmed
    ..Changes in the rpL11 levels might be implicated in cell cycle control and carcinogenesis...
  60. Goudarzi K, Lindström M. Role of ribosomal protein mutations in tumor development (Review). Int J Oncol. 2016;48:1313-24 pubmed publisher
    ..have for example been found in endometrial cancer (RPL22), T-cell acute lymphoblastic leukemia (RPL10, RPL5 and RPL11), chronic lymphocytic leukemia (RPS15), colorectal cancer (RPS20), and glioma (RPL5)...
  61. Cai P, Mao X, Zhao J, Luo L. Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish. Biochem Biophys Res Commun. 2018;497:776-782 pubmed publisher
    ..Mutations in ribosome biogenesis protein Rps19, Rpl5, or Rpl11 can lead to hematopoietic defects in human, thus triggering the disease Diamond Blackfan anemia...
  62. Wang H, Chen T, Weng C, Yang C, Tang M. Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells. Oncotarget. 2016;7:80450-80464 pubmed publisher
    ..It enhances the binding of ribosomal protein RPL11 to MDM2 and reduces the binding of p53 and E2F-1 to MDM2 resulting in stabilization/activation of p53 in A549 ..
  63. Ichimura T, Yoshida K, Okuno Y, Yujiri T, Nagai K, Nishi M, et al. Diagnostic challenge of Diamond-Blackfan anemia in mothers and children by whole-exome sequencing. Int J Hematol. 2017;105:515-520 pubmed publisher
    ..This mother had a frame-shift mutation of RPL11 (exon 3, c.58_59del). Her infant showed transient neonatal anemia, but had no mutations of RP genes...
  64. Koldamova R, Lefterov I, DiSabella M, Almonte C, Watkins S, Lazo J. Human bleomycin hydrolase binds ribosomal proteins. Biochemistry. 1999;38:7111-7 pubmed
    ..Using a yeast two-hybrid system, we found hBH bound to human homologues of rat ribosomal proteins L11 and L29...
  65. Konno Y, Toki T, Tandai S, Xu G, Wang R, Terui K, et al. Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia. Haematologica. 2010;95:1293-9 pubmed publisher
    ..probands) for mutations in the six known genes associated with Diamond-Blackfan anemia: RPS19, RPS24, RPS17, RPL5, RPL11, and RPL35A. RPS14 was also examined due to its implied involvement in 5q- syndrome...
  66. Liu Y, Zhang B, Kuang H, Korakavi G, Lu L, Yu X. Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader. J Biol Chem. 2016;291:13679-88 pubmed publisher
    ..Instead, ZNF618 regulates UHRF2 chromatin localization. Collectively, our study suggests that ZNF618 is a key protein that regulates UHRF2 function as a specific 5hmC reader in vivo. ..
  67. Carlston C, Afify Z, Palumbos J, Bagley H, Barbagelata C, Wooderchak Donahue W, et al. Variable expressivity and incomplete penetrance in a large family with non-classical Diamond-Blackfan anemia associated with ribosomal protein L11 splicing variant. Am J Med Genet A. 2017;173:2622-2627 pubmed publisher
    ..Diamond-Blackfan anemia-7 (DBA7), caused by heterozygous mutations in ribosomal protein L11 (RPL11), accounts for approximately 5% of DBA...
  68. Pereboom T, Bondt A, Pallaki P, Klasson T, Goos Y, Essers P, et al. Translation of branched-chain aminotransferase-1 transcripts is impaired in cells haploinsufficient for ribosomal protein genes. Exp Hematol. 2014;42:394-403.e4 pubmed publisher
    ..cell lines derived from DBA patients carrying various haploinsufficient mutations in either RPS19 or RPL11. Different spectrums of changes were observed depending on the mutant gene, with large differences found in RPS19 ..
  69. López Mateo I, Arruabarrena Aristorena A, Artaza Irigaray C, López J, Calvo E, Belandia B. HEY1 functions are regulated by its phosphorylation at Ser-68. Biosci Rep. 2016;36: pubmed publisher
    ..HEY1 interacts physically with at least one of the ribosomal proteins, RPL11, and both proteins cooperate in the inhibition of MDM2-mediated p53 degradation resulting in a synergistic ..
  70. Odintsova T, Müller E, Ivanov A, Egorov T, Bienert R, Vladimirov S, et al. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. J Protein Chem. 2003;22:249-58 pubmed
    ..Eleven (proteins L7, L10A, L11, L12, L13A, L23, L23A, L27A, L28, L29, and P0) resulted in mass changes that are consistent with N-terminal loss of ..
  71. Llanos S, Serrano M. Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway. Cell Cycle. 2010;9:4005-12 pubmed
    ..which is followed by the binding and inhibition of MDM2 by a different subset of ribosomal proteins that includes L11. Here, we report that depletion of L37 leads to cell cycle arrest in a L11- and p53-dependent manner...
  72. Cui D, Li L, Lou H, Sun H, Ngai S, Shao G, et al. The ribosomal protein S26 regulates p53 activity in response to DNA damage. Oncogene. 2014;33:2225-35 pubmed publisher
    ..In this study we found knockdown of RPS26 induced p53 stabilization and activation via a RPL11-dependent mechanism, resulting in p53-dependent cell growth inhibition...
  73. Chen H, Han L, Tsai H, Wang Z, Wu Y, Duo Y, et al. PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. Oncotarget. 2016;7:83241-83257 pubmed publisher
    ..Furthermore, both phosphorylation and degradation of PICT-1 released RPL11 from the nucleolus to the nucleoplasm, increased binding of RPL11 to MDM2, and promoted p53 accumulation and ..
  74. Kummalue T, Inoue T, Miura Y, Narusawa M, Inoue H, Komatsu N, et al. Ribosomal protein L11- and retinol dehydrogenase 11-induced erythroid proliferation without erythropoietin in UT-7/Epo erythroleukemic cells. Exp Hematol. 2015;43:414-423.e1 pubmed publisher
    ..Lentivirally transduced UT-7/Epo erythroleukemic cells expressing ribosomal protein L11 (RPL11) or retinol dehydrogenase 11 (RDH11) could proliferate in the absence of erythropoietin, and their cell-cycle ..
  75. Zhao W, Zhou C, Li X, Zhang Y, Fan L, Pelletier J, et al. The von Hippel-Lindau protein pVHL inhibits ribosome biogenesis and protein synthesis. J Biol Chem. 2013;288:16588-97 pubmed publisher
    ..Our findings unravel a novel function of pVHL and provide insight into the regulation of ribosome biogenesis by the tumor suppressor pVHL. ..
  76. YOON J, Ling A, Isik M, Lee D, Steinbaugh M, Sack L, et al. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A. 2014;111:3781-6 pubmed publisher
    ..GLTSCR2 controls cellular proliferation and metabolism via the transcription factor Myc, and is induced by mitochondrial stress, suggesting it may constitute a significant component of the mitochondrial signaling pathway. ..
  77. Slomnicki L, CHUNG D, Parker A, Hermann T, Boyd N, Hetman M. Ribosomal stress and Tp53-mediated neuronal apoptosis in response to capsid protein of the Zika virus. Sci Rep. 2017;7:16652 pubmed publisher
    ..manipulations targeting the ribosomal stress effector Tp53 or knockdown of the ribosomal stress mediator RPL11. Finally, capsid protein of Dengue virus, but not West Nile virus, induced ribosomal stress and apoptosis...
  78. Chakraborty A, Uechi T, Nakajima Y, Gazda H, O Donohue M, Gleizes P, et al. Cross talk between TP53 and c-Myc in the pathophysiology of Diamond-Blackfan anemia: Evidence from RPL11-deficient in vivo and in vitro models. Biochem Biophys Res Commun. 2018;495:1839-1845 pubmed publisher
    ..Interestingly, RPL11 also controls the transcriptional activity of c-Myc, an oncoprotein that positively regulates ribosome biogenesis...
  79. Yu W, Qiu Z, Gao N, Wang L, Cui H, Qian Y, et al. PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop. Nucleic Acids Res. 2011;39:2234-48 pubmed publisher
    ..Deficiency of PAK1IP1 increased free ribosomal protein L5 and L11 which were required for PAK1IP1 depletion-induced p53 activation...
  80. Ebina M, Tsuruta F, Katoh M, Kigoshi Y, Someya A, Chiba T. Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification. PLoS ONE. 2013;8:e65285 pubmed publisher
    ..that modification by a ubiquitin-like molecule, Nedd8, regulates subnuclear localization of ribosomal protein L11. Most of L11 is normally localized and neddylated in nucleolus...
  81. Teng T, Mercer C, Hexley P, Thomas G, Fumagalli S. Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity. Mol Cell Biol. 2013;33:4660-71 pubmed publisher
    ..that lead to cancer, including the binding and inhibition of Hdm2 by the 60S ribosomal proteins (RPs) RPL5 and RPL11. This same mechanism appears to be activated upon impaired ribosome biogenesis, a risk factor for cancer ..
  82. Liao J, Zhou X, Gatignol A, Lu H. Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex. Oncogene. 2014;33:4916-23 pubmed publisher
    ..Here, we show that RPL5, co-operatively with RPL11, guides the RNA-induced silencing complex (RISC) to c-Myc mRNA and mediates the degradation of the mRNA, ..
  83. Narla A, Yuan D, Kazerounian S, LaVasseur C, Ulirsch J, Narla J, et al. A novel pathogenic mutation in RPL11 identified in a patient diagnosed with diamond Blackfan anemia as a young adult. Blood Cells Mol Dis. 2016;61:46-7 pubmed publisher
  84. Donati G, Bertoni S, Brighenti E, Vici M, Trere D, Volarevic S, et al. The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells. Oncogene. 2011;30:3274-88 pubmed publisher
  85. Wang X, Ren Y, Wang Z, Xiong X, Han S, Pan W, et al. Down-regulation of 5S rRNA by miR-150 and miR-383 enhances c-Myc-rpL11 interaction and inhibits proliferation of esophageal squamous carcinoma cells. FEBS Lett. 2015;589:3989-97 pubmed publisher
    ..Moreover, 5S rRNA silencing by miR-150 and miR-383 might intensify rpL11-c-Myc interaction, which attenuated role of c-Myc as an oncogenic transcriptional factor and dysregulation of ..
  86. Tsoi H, Lam K, Dong Y, Zhang X, Lee C, Zhang J, et al. Pre-45s rRNA promotes colon cancer and is associated with poor survival of CRC patients. Oncogene. 2017;36:6109-6118 pubmed publisher
    ..cell-cycle transition by stabilizing p53 through inducing murine double minute 2 (MDM2) and ribosomal protein L11 (RpL11) interaction...
  87. Bernardi R, Scaglioni P, Bergmann S, Horn H, Vousden K, Pandolfi P. PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat Cell Biol. 2004;6:665-72 pubmed
    ..Furthermore, we demonstrate that PML physically associates with the nucleolar protein L11, and that L11 knockdown impairs the ability of PML to localize to nucleoli after DNA damage...
  88. Frum R, Busby S, Ramamoorthy M, Deb S, Shabanowitz J, Hunt D, et al. HDM2-binding partners: interaction with translation elongation factor EF1alpha. J Proteome Res. 2007;6:1410-7 pubmed
    ..with EF1alpha, suggesting that the interaction is independent of its other ribosomal interacting proteins L5, L11, and L23. Overexpression of HDM2 did not affect translation...
  89. Yamashita A, Izumi N, Kashima I, Ohnishi T, Saari B, Katsuhata Y, et al. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev. 2009;23:1091-105 pubmed publisher
  90. Moniz H, Gastou M, Leblanc T, Hurtaud C, Crétien A, Lecluse Y, et al. Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro. Cell Death Dis. 2012;3:e356 pubmed publisher
    ..understanding of DBA pathogenesis, we studied CD34? cells from peripheral blood of DBA patients carrying RPL11 and RPS19 ribosomal gene mutations and determined their ability to undergo erythroid differentiation in vitro...
  91. Robledo S, Idol R, Crimmins D, Ladenson J, Mason P, Bessler M. The role of human ribosomal proteins in the maturation of rRNA and ribosome production. RNA. 2008;14:1918-29 pubmed publisher
    ..of the small (RPS6, RPS7, RPS15, RPS16, RPS17, RPS19, RPS24, RPS25, RPS28) or large subunit (RPL5, RPL7, RPL11, RPL14, RPL26, RPL35a) and studied the effect on rRNA processing and ribosome production...
  92. Turi Z, Senkyrikova M, Mistrik M, Bartek J, Moudry P. Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cells. Cell Cycle. 2017;:1-27 pubmed publisher
    ..also caused disruption of nucleolar structure and activated the ribosomal biogenesis stress pathway - RPL5 / RPL11 dependent stabilization and activation of p53...