Gene Symbol: RPK118
Description: ribosomal protein S6 kinase C1
Alias: RPK118, RSKL1, S6K-delta-1, S6PKh1, humS6PKh1, ribosomal protein S6 kinase delta-1, 52 kDa ribosomal protein S6 kinase, SPHK1-binding protein, ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein, ribosomal protein S6 kinase, 52kDa, polypeptide 1
Bleeker F, Lamba S, Zanon C, Molenaar R, Hulsebos T, Troost D, et al
. Mutational profiling of kinases in glioblastoma. BMC Cancer. 2014;14:718 pubmed publisher
..Other therapies should be investigated, targeting early events in gliomagenesis that involve both kinases and non-kinases. ..
Zhang Y, Wester L, He J, Geiger T, Moerkens M, Siddappa R, et al
. IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer. Oncogene. 2018;37:1869-1884 pubmed publisher
..Targeting PIXα/β entirely mimics the effect of PAK2 silencing on antiestrogen re-sensitization. These data indicate PAK2/PIX as an effector pathway in IGF1R-mediated antiestrogen resistance. ..
Zhang H, Yu L, Mao N, Fu Q, Tu Q, Gao J, et al
. Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1. Genomics. 1999;61:314-8 pubmed
Hayashi S, Okada T, Igarashi N, Fujita T, Jahangeer S, Nakamura S. Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein. J Biol Chem. 2002;277:33319-24 pubmed
..Here we have cloned a novel sphingosine kinase-1 (SPHK1)-binding protein, RPK118, by yeast two-hybrid screening...
Leparc G, Mitra R. Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human. Nucleic Acids Res. 2007;35:3192-202 pubmed
..Overall, PASE was able to uncover 59 novel alternative cassette exons in C. elegans and humans through a genome-wide ab initio prediction method that enriches for exons involved in signaling. ..
Liu L, Yang C, Yuan J, Chen X, Xu J, Wei Y, et al
. RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains. Mol Cells. 2005;19:39-45 pubmed
b>RPK118 is a sphingosine kinase-1-binding protein that has been implicated in sphingosine 1 phosphate-mediated signaling...