Gene Symbol: RP105
Description: CD180 molecule
Alias: LY64, Ly78, RP105, CD180 antigen, lymphocyte antigen 64, lymphocyte antigen-64, radioprotective, 105kDa, radioprotective 105 kDa protein
Species: human
Products:     RP105

Top Publications

  1. Miyake K, Shimazu R, Kondo J, Niki T, Akashi S, Ogata H, et al. Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. J Immunol. 1998;161:1348-53 pubmed
    b>RP105 is a leucine-rich repeat molecule that is expressed on mouse B cells and transmits a growth-promoting signal. An anti-RP105 Ab precipitated additional molecules as well as RP105...
  2. Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, et al. RP105 is associated with MD-1 and transmits an activation signal in human B cells. Blood. 1998;92:2815-22 pubmed
    b>RP105 was originally discovered as a mouse B-cell surface molecule that transmits an activation signal. The signal leads to resistance against irradiation-induced apoptosis and massive B-cell proliferation...
  3. Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland N, Gilbert D, et al. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). Genomics. 1996;38:299-304 pubmed
    b>RP105 is a mouse B cell surface molecule that transmits a growth-promoting signal and is implicated in the life/death decision of B cells...
  4. Yang J, Zeng P, Yang J, Fan Z. The Role of RP105 in Cardiovascular Disease through Regulating TLR4 and PI3K Signaling Pathways. Curr Med Sci. 2019;39:185-189 pubmed publisher
    Raidoprotective 105 (RP105) was first discovered on the surface of mouse B cells and it has been demonstrated that RP105 can function as an inflammatory regulator in cardiovascular disease (CVD), such as myocardial ischemic reperfusion ..
  5. Zhang Z, La Placa D, Nguyen T, Kujawski M, Le K, Li L, et al. CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes. BMC Immunol. 2019;20:7 pubmed publisher
    ..Instead, the alternative LPS receptor RP105 is expressed and recruits MD1, CD14, Src, VAV1 and β-actin in response to LPS...
  6. Wu J, Sheng Y, Sui J, Weng X. [Characteristics of CD180 Expression and Its Diagnostic Value in B Cell Chronic Lymphoproliferative Disorders]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018;26:1811-1815 pubmed publisher
    ..Utilizing the multiparameter flow cytometry for defecting expression of CD180 and other immunological markers can more efficiently distinguish the subtypes of B-CLPD. ..
  7. Eriksen A, Berge T, Gustavsen M, Leikfoss I, Bos S, Spurkland A, et al. Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis. J Neuroimmunol. 2015;278:11-8 pubmed publisher
    ..When co-stimulated via the toll-like receptors (TLRs) TLR9 and RP105, MS B cells secreted less of the anti-inflammatory cytokine interleukin 10 (IL-10) compared to B cells from ..
  8. Dong G, Yao X, Yan F, Zhang H, Zhu Y, Yang Y, et al. Ligation of CD180 contributes to endotoxic shock by regulating the accumulation and immunosuppressive activity of myeloid-derived suppressor cells through STAT3. Biochim Biophys Acta Mol Basis Dis. 2019;1865:535-546 pubmed publisher
  9. Hu Y, Wei X, Liao Z, Gao Y, Liu X, Su J, et al. Transcriptome Analysis Provides Insights into the Markers of Resting and LPS-Activated Macrophages in Grass Carp (Ctenopharyngodon idella). Int J Mol Sci. 2018;19: pubmed publisher
    ..Transcriptome profiling reveals novel molecules associated with macrophages in C. Idella, which may represent a potential target for macrophages activation. ..

More Information


  1. Candel S, Sepulcre M, Espin Palazon R, Tyrkalska S, de Oliveira S, Meseguer J, et al. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish. Dev Comp Immunol. 2015;50:155-65 pubmed publisher
    ..Later, MD1 and RP105 were shown to form complexes that directly interact with the MD2-TLR4 complex, acting as physiological negative ..
  2. Wezel A, van der Velden D, Maassen J, Lagraauw H, De Vries M, Karper J, et al. RP105 deficiency attenuates early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner. Atherosclerosis. 2015;238:132-9 pubmed publisher
    ..RadioProtective 105 (RP105) is a structural homolog of TLR4 and an important regulator of TLR4 signaling, suggesting that RP105 may also be ..
  3. Yang Y, Yang J, Liu X, Ding J, Li S, Guo X, et al. Down-Regulation of miR-327 Alleviates Ischemia/Reperfusion-Induced Myocardial Damage by Targeting RP105. Cell Physiol Biochem. 2018;49:1049-1063 pubmed publisher
    ..Via TargetScan, we found RP105 is a possible target gene of miR-327; our previous studies have also confirmed that RP105 acted as a ..
  4. Pivovarova O, Jürchott K, Rudovich N, Hornemann S, Ye L, Möckel S, et al. Changes of Dietary Fat and Carbohydrate Content Alter Central and Peripheral Clock in Humans. J Clin Endocrinol Metab. 2015;100:2291-302 pubmed publisher
    ..Our results suggest that the modulation of the dietary fat and carbohydrate content alters the function of the central and peripheral circadian clocks in humans. ..
  5. Murofushi Y, Villena J, Morie K, Kanmani P, Tohno M, Shimazu T, et al. The toll-like receptor family protein RP105/MD1 complex is involved in the immunoregulatory effect of exopolysaccharides from Lactobacillus plantarum N14. Mol Immunol. 2015;64:63-75 pubmed publisher
    The radioprotective 105 (RP105)/MD1 complex is a member of the Toll-like receptor (TLR) family...
  6. Kunda P, Cavicchia J, Acosta C. Lipopolysaccharides and trophic factors regulate the LPS receptor complex in nodose and trigeminal neurons. Neuroscience. 2014;280:60-72 pubmed publisher
    ..pattern and regulation by LPS and trophic factors of TLR4/MD2/CD14 and radioprotective protein of 105kDa (RP105)/MD1 were determined in neonatal trigeminal and nodose mice neurons...
  7. Eriksen A, Torgersen M, Holm K, Abrahamsen G, Spurkland A, Moskaug J, et al. Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy. Autophagy. 2015;11:460-71 pubmed publisher
    ..We propose that the identified prominent role of autophagy in RA-mediated IgG-production in normal human B cells provides a novel mechanism whereby vitamin A exerts its important functions in the immune system. ..
  8. Hobeika E, Levit Zerdoun E, Anastasopoulou V, Pohlmeyer R, Altmeier S, Alsadeq A, et al. CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk. EMBO J. 2015;34:925-39 pubmed publisher
    ..Syk-negative B cells are defective in BCR, RP105 and CD38 signaling but still respond to an IL-4, anti-CD40, CpG or LPS stimulus...
  9. Louwe M, Karper J, de Vries M, Nossent A, Bastiaansen A, van der Hoorn J, et al. RP105 deficiency aggravates cardiac dysfunction after myocardial infarction in mice. Int J Cardiol. 2014;176:788-93 pubmed publisher
    ..b>RP105 (CD180) is a TLR4 homolog lacking the intracellular signaling domain that competitively inhibits TLR4-signaling...
  10. Weekes M, Antrobus R, Talbot S, Hör S, Simecek N, Smith D, et al. Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6. J Proteome Res. 2012;11:1475-84 pubmed publisher
    ..This study therefore identifies the extended LDL receptor family as an important new family of proteins whose cell surface expression is regulated by gp96. ..
  11. Brühl H, Cihak J, Talke Y, Rodriguez Gomez M, Hermann F, Goebel N, et al. B-cell inhibition by cross-linking CD79b is superior to B-cell depletion with anti-CD20 antibodies in treating murine collagen-induced arthritis. Eur J Immunol. 2015;45:705-15 pubmed publisher
    ..These findings may have important implications for treatment of B-cell-mediated autoimmune diseases. ..
  12. Mestrallet F, Sujobert P, Sarkozy C, Traverse Glehen A, Callet Bauchu E, Magaud J, et al. CD180 overexpression in follicular lymphoma is restricted to the lymph node compartment. Cytometry B Clin Cytom. 2016;90:433-9 pubmed publisher
    ..These FCM data confirm the usefulness of CD180 in the accurate diagnosis of LPDs and emphasize the need to interpret this marker according to the origin of the sample. © 2015 Clinical Cytometry Society. ..
  13. Indrevær R, Moskaug J, Paur I, Bøhn S, Jørgensen S, Blomhoff R, et al. IRF4 Is a Critical Gene in Retinoic Acid-Mediated Plasma Cell Formation and Is Deregulated in Common Variable Immunodeficiency-Derived B Cells. J Immunol. 2015;195:2601-11 pubmed publisher
    ..RA) promotes the formation of plasma cells upon stimulation of B cells via the innate immunity receptors TLR9 and RP105. Most often, differentiation of B cells involves the sequential events of class switch recombination and somatic ..
  14. Wezel A, De Vries M, Maassen J, Kip P, Peters E, Karper J, et al. Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response. Sci Rep. 2016;6:24248 pubmed publisher
    ..Here, we investigate the effects of the accessory molecule and TLR4 analogue RadioProtective 105 (RP105) on vein graft disease. RP105 deficiency resulted in a 90% increase in vein graft lesion area compared to controls...
  15. Kobo H, Bar Shira A, Dahary D, Gan Or Z, Mirelman A, Goldstein O, et al. Down-regulation of B cell-related genes in peripheral blood leukocytes of Parkinson's disease patients with and without GBA mutations. Mol Genet Metab. 2016;117:179-85 pubmed publisher
    ..These results further support the involvement of B cell-related genes in PD and correlate the level of reduced expression to disease duration. ..
  16. Xiong X, Liu Y, Mei Y, Peng J, Wang Z, Kong B, et al. Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling. Sci Rep. 2017;7:41857 pubmed publisher
    Myeloid differentiation 1 (MD-1), a secreted protein interacting with radioprotective 105 (RP105), plays an important role in Toll-like receptor 4 (TLR4) signalling pathway...
  17. Thomas Jennings R, Odkhuu E, Nakashima A, Morita N, Kobayashi T, Yamai I, et al. Inflammatory responses increase secretion of MD-1 protein. Int Immunol. 2016;28:503-512 pubmed
    Radioprotective 105 (RP105) is a type I transmembrane protein, which associates with a glycoprotein, MD-1. Monoclonal antibody (mAb)-mediated ligation of RP105/MD-1 robustly activates B cells...
  18. Ohyama K, Huy N, Yoshimi H, Kishikawa N, Nishizawa J, Roca Y, et al. Proteomic profile of circulating immune complexes in chronic Chagas disease. Parasite Immunol. 2016;38:609-17 pubmed publisher
    ..cruzi antigens (surface protease GP63, glucose-6-isomerase) and six human autoantigens (CD180 antigen, ceruloplasmin, fibrinogen beta chain, fibrinogen beta chain isoform 2 preprotein, isoform gamma-A of ..
  19. Ortiz Suarez M, Bond P. The Structural Basis for Lipid and Endotoxin Binding in RP105-MD-1, and Consequences for Regulation of Host Lipopolysaccharide Sensitivity. Structure. 2016;24:200-211 pubmed publisher
    MD-1 is a member of the MD-2-related lipid-recognition (ML) family, and associates with RP105, a cell-surface protein that resembles Toll-like receptor 4 (TLR4)...
  20. Carreras González A, Navasa N, Martín Ruiz I, Lavín J, Azkargorta M, Atondo E, et al. A multi-omic analysis reveals the regulatory role of CD180 during the response of macrophages to Borrelia burgdorferi. Emerg Microbes Infect. 2018;7:19 pubmed publisher
  21. Mayeur Rousse C, Guy J, Miguet L, Bouyer S, Geneviève F, Robillard N, et al. CD180 expression in B-cell lymphomas: A multicenter GEIL study. Cytometry B Clin Cytom. 2016;90:462-6 pubmed publisher
    ..Harmonization process is of great interest in order to evaluate new markers in multicentric studies and to set up decisional thresholds. © 2015 International Clinical Cytometry Society. ..
  22. Guo X, Jiang H, Yang J, Chen J, Yang J, Ding J, et al. Radioprotective 105 kDa protein attenuates ischemia/reperfusion-induced myocardial apoptosis and autophagy by inhibiting the activation of the TLR4/NF-?B signaling pathway in rats. Int J Mol Med. 2016;38:885-93 pubmed publisher
    ..Radioprotective 105 kDa protein (RP105) is a specific inhibitor of TLR4...
  23. Laiño J, Villena J, Kanmani P, Kitazawa H. Immunoregulatory Effects Triggered by Lactic Acid Bacteria Exopolysaccharides: New Insights into Molecular Interactions with Host Cells. Microorganisms. 2016;4: pubmed publisher
    ..We also reported that the radioprotective 105 (RP105)/MD1 complex, a member of the TLR family, is partially involved in the immunoregulatory effects of the EPS from ..
  24. Pan H, Zhang G, Zhang L, Wang W, Shang J, Wang X, et al. MD-1 deficiency attenuates dextran sodium sulfate (DSS)-induced colitis through modulating the function of colonic lamina propria dendritic cells. Mol Immunol. 2016;75:1-10 pubmed publisher
    ..1 (MD-1), also known as Lymphocyte Antigen 86 (Ly86), a secreted protein interacting with radioprotective 105 (RP105), plays an important role in Toll-like receptor 4 (TLR4) signaling pathway...
  25. Hong F, Mohammad Rachidi S, Lundgren D, Han D, Huang X, Zhao H, et al. Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90. PLoS ONE. 2017;12:e0169260 pubmed publisher
    ..Taken together, our study establishes gp96 as a critical chaperone to integrate innate immunity, Wnt signaling and organ development. ..
  26. Yu C, Micaroni M, Puyskens A, Schultz T, Yeo J, Stanley A, et al. RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection. J Immunol. 2015;195:3890-900 pubmed publisher
    ..We demonstrate that the p110δ catalytic subunit of PI3K acts as a downstream effector of the TLR family member RP105 (CD180) in promoting mycobacteria-induced cytokine production by macrophages...
  27. Matsushima N, Miyashita H, Enkhbayar P, Kretsinger R. Comparative Geometrical Analysis of Leucine-Rich Repeat Structures in the Nod-Like and Toll-Like Receptors in Vertebrate Innate Immunity. Biomolecules. 2015;5:1955-78 pubmed publisher
    ..In contrast, the TLR LRRs adopt either a left-handed helix or are nearly flat; RP105 and CD14 also adopt a left-handed helix...
  28. Kikuchi J, Kuroda Y, Koyama D, Osada N, Izumi T, Yasui H, et al. Myeloma Cells Are Activated in Bone Marrow Microenvironment by the CD180/MD-1 Complex, Which Senses Lipopolysaccharide. Cancer Res. 2018;78:1766-1778 pubmed publisher
    ..i>Cancer Res; 78(7); 1766-78. ©2018 AACR. ..
  29. Candel S, Tyrkalska S, García Moreno D, Meseguer J, Mulero V. Identification of Evolutionarily Conserved Md1 Splice Variants That Regulate Innate Immunity through Differential Induction of NF-кB. J Immunol. 2016;197:1379-88 pubmed publisher
    ..factor (MD)2/CD14 complex is responsible for the recognition of bacterial LPS, and it is known that the RP105/MD1 complex negatively regulates TLR4 signaling, the evolutionary history of LPS recognition remains enigmatic...
  30. Yang J, Guo X, Yang J, Ding J, Li S, Yang R, et al. RP105 Protects Against Apoptosis in Ischemia/Reperfusion-Induced Myocardial Damage in Rats by Suppressing TLR4-Mediated Signaling Pathways. Cell Physiol Biochem. 2015;36:2137-48 pubmed publisher
    ..Toll-like receptor 4 (TLR4) is a potent inducer of these apoptotic cascades. In contrast, the radioprotective 105 kDa protein (RP105) is a specific negative regulator of TLR4 signaling pathways...
  31. Li X, Yang J, Yang J, Dong W, Li S, Wu H, et al. RP105 protects against myocardial ischemia-reperfusion injury via suppressing TLR4 signaling pathways in rat model. Exp Mol Pathol. 2016;100:281-6 pubmed publisher
    ..b>Radioprotective 105 kDa protein (RP105) is a regulator of Toll-like receptor 4 (TLR4), an inflammatory factor whose functions have ..
  32. Polson A, Calemine Fenaux J, Chan P, Chang W, Christensen E, Clark S, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res. 2009;69:2358-64 pubmed publisher
    ..Thus, our data suggest that ADCs with cleavable linkers work on a broad range of targets, and for specific targets, ADCs with uncleavable linkers provide a promising opportunity to improve the therapeutic window for ADCs in humans. ..
  33. Valori M, Jansson L, Kiviharju A, Ellonen P, Rajala H, Awad S, et al. A novel class of somatic mutations in blood detected preferentially in CD8+ cells. Clin Immunol. 2017;175:75-81 pubmed publisher
    ..Whether some of this class of mutations plays a role in disease is currently unclear, but these results define an interesting hitherto unknown research target for future studies. ..
  34. Yeh T, O Connor G, Petteruti P, Dulak A, Hattersley M, Barrett J, et al. Identification of CCR2 and CD180 as Robust Pharmacodynamic Tumor and Blood Biomarkers for Clinical Use with BRD4/BET Inhibitors. Clin Cancer Res. 2017;23:1025-1035 pubmed publisher
    ..MYC mRNA is useful as a hematologic tumor-based biomarker but suboptimal as a whole blood biomarker. Utility of HEXIM1 mRNA may be limited to higher concentrations. Clin Cancer Res; 23(4); 1025-35. ©2017 AACR. ..
  35. Okamoto N, Mizote K, Honda H, Saeki A, Watanabe Y, Yamaguchi Miyamoto T, et al. Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex. J Biol Chem. 2017;292:15378-15394 pubmed publisher
    ..Biacore analysis revealed that FNC-RED binds to murine TLR4/MD-2 but not murine radioprotective 105 (RP105)/myeloid differentiation factor-1 (MD-1), another LPS sensor...
  36. Bezhaeva T, Wong C, De Vries M, van der Veer E, van Alem C, Que I, et al. Deficiency of TLR4 homologue RP105 aggravates outward remodeling in a murine model of arteriovenous fistula failure. Sci Rep. 2017;7:10269 pubmed publisher
    ..b>RP105 is a critical physiologic regulator of TLR4 signaling in numerous cell types...
  37. Gordiienko I, Shlapatska L, Kholodniuk V, Sklyarenko L, Gluzman D, Clark E, et al. The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling. PLoS ONE. 2017;12:e0185940 pubmed publisher
  38. Longtine M, Cvitic S, Colvin B, Chen B, Desoye G, Nelson D. Calcitriol regulates immune genes CD14 and CD180 to modulate LPS responses in human trophoblasts. Reproduction. 2017;154:735-744 pubmed publisher
    ..Notably, we found an inverse effect of calcitriol on expression of CD14 and CD180/RP105, proteins that differentially regulate toll-like receptor 4-mediated immune responses...
  39. Giordano D, Draves K, Young L, Roe K, Bryan M, Dresch C, et al. Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization. PLoS Pathog. 2017;13:e1006743 pubmed publisher
    ..Thus, the immature B cells present in BAFFR-/- and not ?MT mice contribute to protective antiviral immunity. A CD180-based vaccine may promote immunity in immunocompromised individuals...
  40. You M, Dong G, Li F, Ma F, Ren J, Xu Y, et al. Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells. Cell Mol Immunol. 2017;14:192-202 pubmed publisher
    ..Our data provide molecular insight into the mechanism of IFN-α signaling activation in SLE B cells and a potential therapeutic approach for SLE treatment. ..
  41. Eriksen A, Indrevær R, Holm K, Landskron J, Blomhoff H. TLR9-signaling is required for turning retinoic acid into a potent stimulator of RP105 (CD180)-mediated proliferation and IgG synthesis in human memory B cells. Cell Immunol. 2012;279:87-95 pubmed publisher
    ..Here we explore the impact of all-trans retinoic acid (RA) on B cell responses mediated via the TLR homolog RP105 (CD180)...
  42. Yoon S, Hong M, Wilson I. An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1. Nat Struct Mol Biol. 2011;18:1028-35 pubmed publisher
    b>RP105-MD-1 modulates the TLR4-MD-2-mediated, innate immune response against bacterial lipopolysaccharide (LPS). The crystal structure of the bovine 1:1 RP105-MD-1 complex bound to a putative endogenous lipid at 2...
  43. Antosz H, Sajewicz J, Marzec Kotarska B, Kocki J, Dmoszynska A. Different expression of CD180, CD284 and CD14 receptors on the CD19+ subpopulation of normal and B-CLL lymphocytes. Folia Histochem Cytobiol. 2009;47:593-8 pubmed publisher
    ..Variations observed in expression of both normal and leukemic receptors may be due to their different sensitivity to antigenic stimulation. ..
  44. Yamazaki K, Yamazaki T, Taki S, Miyake K, Hayashi T, Ochs H, et al. Potentiation of TLR9 responses for human naïve B-cell growth through RP105 signaling. Clin Immunol. 2010;135:125-36 pubmed publisher
    ..We explored the effects of RP105 (CD180) on CpG DNA-activated naïve and memory B cells from normal controls and patients with common variable ..
  45. Divanovic S, Trompette A, Atabani S, Madan R, Golenbock D, Visintin A, et al. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat Immunol. 2005;6:571-8 pubmed
    ..Such responses demand tight regulation. RP105 is a TLR homolog thought to be mostly B cell specific, lacking a signaling domain...
  46. Gordiienko I, Shlapatska L, Kholodniuk V, Kovalevska L, Ivanivskaya T, Sidorenko S. CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells. Exp Oncol. 2017;39:291-298 pubmed
    ..Analysis of TFs expression profile revealed upregulated SPIB mRNA level and downregulated PU.1 in CLL cells. CD150 and CD180 receptors may modulate transcriptional program in CLL cells by regulating the TFs expression levels. ..
  47. Ogata H, Su I, Miyake K, Nagai Y, Akashi S, Mecklenbrauker I, et al. The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J Exp Med. 2000;192:23-9 pubmed
    ..Here, we demonstrate that the responses of B cells to LPS are also regulated by another TLR protein, RP105, which is predominantly expressed on mature B cells in mice and humans...
  48. Tsertsvadze T, Mitskevich N, Bilanishvili A, Girdaladze D, Porakishvili N. PHAGOCYTOSIS AND EXPRESSION OF FCg-RECEPTORS AND CD180 ON MONOCYTES IN CHRONIC LYMPHOCYTIC LEUKEMIA. Georgian Med News. 2017;:88-93 pubmed
    ..Our data indicates that the decreased functional status of monocytes in CLL might contribute to the diminished efficacy of therapeutic antibodies as well as to the immunodeficiency, characteristic for these patients...
  49. Schultz T, Blumenthal A. The RP105/MD-1 complex: molecular signaling mechanisms and pathophysiological implications. J Leukoc Biol. 2017;101:183-192 pubmed publisher
  50. Tsertsvadze T, Mitskevich N, Ghirdaladze D, Porakishvili N. Correlation of the expression of CD32 and CD180 receptors on CLL cells and MEC1 cell line. Georgian Med News. 2015;:56-9 pubmed
    ..Since MEC1 cells are derived from a CLL patient with mutated IGVH genes (M-CLL) negative correlation between CD180 and CD32 expression on cycling MEC1 cells could be limited to M-CLL. ..
  51. Ohto U, Miyake K, Shimizu T. Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family. J Mol Biol. 2011;413:815-25 pubmed publisher
    The Toll-like receptor (TLR) 4/MD-2 heterodimer senses lipopolysaccharide (LPS). RP105 (radioprotective 105 kDa), a TLR-related molecule, is similar to TLR4 in that the extracellular leucine-rich repeats associate with MD-1, the MD-2-..
  52. Sun Y, Guo Q, Liu D, Zhang M, Shu R. In vivo expression of Toll-like receptor 2, Toll-like receptor 4, CSF2 and LY64 in Chinese chronic periodontitis patients. Oral Dis. 2010;16:343-50 pubmed publisher
    ..Colony stimulating factor 2 (CSF2) is a cytokine that may prevent endotoxin tolerance, and LY64 has the ability to interfere with the recognition of bacteria via TLR4...
  53. Honda Y, Yamagiwa S, Matsuda Y, Takamura M, Ichida T, Aoyagi Y. Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis. J Hepatol. 2007;47:404-11 pubmed
    ..Of significance, the surface expression of RP105, which has recently been shown to be involved in negative regulation of TLR4 signaling, on PBC monocytes was ..
  54. Egli N, Zajonz A, Burger M, Schweighoffer T. Human CD180 Transmits Signals via the PIM-1L Kinase. PLoS ONE. 2015;10:e0142741 pubmed publisher
    ..Pharmacological inhibition of PIM-1 should therefore provide novel therapeutic options in diseases that respond to innate immune stimulation with subsequently increased B cell activity, such as lupus erythematosus or myasthenia gravis. ..
  55. Tsertsvadze T, Mitskevich N, Ghirdaladze D, Porakishvili N. Aberrant expression of Fcγ-receptors and Toll like receptor CD180 on monocytes from patients with chronic lymphocytic leukaemia. Georgian Med News. 2015;:35-8 pubmed
    ..In addition, aberrant expression of CD64 would negatively affect the efficiency of antibody-mediated immunotherapies. ..
  56. Woodward E, Kolesnik T, Nicholson S, Prele C, Hart P. The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10, RP105 or the kinase activity of RIPK2. Cytokine. 2012;58:415-23 pubmed publisher
    ..of IL-10 mRNA and protein and mRNA for receptor-interacting serine-threonine kinase 2 (RIPK2), the TLR homolog, RP105, and c-Maf, a transcription factor required for IL-10 gene expression...