ROS1

Summary

Gene Symbol: ROS1
Description: ROS proto-oncogene 1, receptor tyrosine kinase
Alias: MCF3, ROS, c-ros-1, proto-oncogene tyrosine-protein kinase ROS, ROS proto-oncogene 1 , receptor tyrosine kinase, c-ros oncogene 1 , receptor tyrosine kinase, proto-oncogene c-Ros-1, transmembrane tyrosine-specific protein kinase, v-ros avian UR2 sarcoma virus oncogene homolog 1
Species: human
Products:     ROS1

Top Publications

  1. Birchmeier C, O Neill K, Riggs M, Wigler M. Characterization of ROS1 cDNA from a human glioblastoma cell line. Proc Natl Acad Sci U S A. 1990;87:4799-803 pubmed
    We have isolated and characterized a human ROS1 cDNA from the glioblastoma cell line SW-1088. The cDNA, 8...
  2. Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012;18:378-81 pubmed publisher
    ..a screening for fusions of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1, receptor tyrosine kinase (ROS1) in 1,529 lung cancers and identified 44 ALK-fusion-positive and 13 ROS1-fusion-positive adenocarcinomas, including ..
  3. Yasuda H, de Figueiredo Pontes L, Kobayashi S, Costa D. Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer. J Thorac Oncol. 2012;7:1086-90 pubmed publisher
    ..that one of these multi-targeted tyrosine kinase inhibitors (TKIs) would have antiproliferative activity against ROS1 translocated non-small-cell lung cancer (NSCLC)...
  4. Bergethon K, Shaw A, Ou S, Katayama R, Lovly C, McDonald N, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol. 2012;30:863-70 pubmed publisher
    Chromosomal rearrangements involving the ROS1 receptor tyrosine kinase gene have recently been described in a subset of non-small-cell lung cancers (NSCLCs)...
  5. Rimkunas V, Crosby K, Li D, Hu Y, Kelly M, Gu T, et al. Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion. Clin Cancer Res. 2012;18:4449-57 pubmed publisher
    To deepen our understanding of mutant ROS1 expression, localization, and frequency in non-small cell lung cancer (NSCLC), we developed a highly specific and sensitive immunohistochemistry (IHC)-based assay that is useful for the detection ..
  6. Lee J, Lee S, Kang S, Do I, Lee S, Ha S, et al. Identification of ROS1 rearrangement in gastric adenocarcinoma. Cancer. 2013;119:1627-35 pubmed publisher
    ..One of these RTKs, c-ros oncogene 1, receptor tyrosine kinase (ROS1), has been identified as a driver mutation in NSCLC, because its inhibition by crizotinib, an anaplastic lymphoma ..
  7. Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007;131:1190-203 pubmed
    ..are generated and analyzed to identify known oncogenic kinases such as EGFR and c-Met as well as novel ALK and ROS fusion proteins...
  8. Oxnard G, Binder A, Janne P. New targetable oncogenes in non-small-cell lung cancer. J Clin Oncol. 2013;31:1097-104 pubmed publisher
    ..in recent years, including BRAF mutations, HER2 insertions, PIK3CA mutations, FGFR1 amplifications, DDR2 mutations, ROS1 rearrangements, and RET rearrangements...
  9. Birchmeier C, Sharma S, Wigler M. Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proc Natl Acad Sci U S A. 1987;84:9270-4 pubmed
    The human ROS1 gene, which possibly encodes a growth factor receptor, was found to be expressed in human tumor cell lines...

More Information

Publications126 found, 100 shown here

  1. Charest A, Wilker E, McLaughlin M, Lane K, Gowda R, Coven S, et al. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 2006;66:7473-81 pubmed
    ..In fact, ectopic expression of the orphan RTK ROS is a frequent event in human brain cancers, yet the pathologic significance of this expression remains undetermined...
  2. Sholl L, Sun H, Butaney M, Zhang C, Lee C, Janne P, et al. ROS1 immunohistochemistry for detection of ROS1-rearranged lung adenocarcinomas. Am J Surg Pathol. 2013;37:1441-9 pubmed publisher
    b>ROS1 gene rearrangements are reported in 1% to 2% of lung adenocarcinomas (ACAs) and are associated with response to the multitargeted tyrosine kinase inhibitor crizotinib...
  3. Birchmeier C, Birnbaum D, Waitches G, Fasano O, Wigler M. Characterization of an activated human ros gene. Mol Cell Biol. 1986;6:3109-16 pubmed
    A human oncogene, mcf3, previously detected by a combination of DNA-mediated gene transfer and a tumorigenicity assay, derives from a human homology of the avian v-ros oncogene...
  4. Charest A, Kheifets V, Park J, Lane K, McMahon K, Nutt C, et al. Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma. Proc Natl Acad Sci U S A. 2003;100:916-21 pubmed
    ..fusion of FIG, a gene coding for a Golgi apparatus-associated protein, to the kinase domain of the protooncogene c-ROS. The fused protein product FIG-ROS is a potent oncogene, and its transforming potential resides in its ability to ..
  5. Charest A, Lane K, McMahon K, Park J, Preisinger E, Conroy H, et al. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer. 2003;37:58-71 pubmed
    The transmembrane proto-oncogene receptor tyrosine kinase (RTK) ROS is an orphan receptor that is aberrantly expressed in neoplasms of the central nervous system...
  6. Gu T, Deng X, Huang F, Tucker M, Crosby K, Rimkunas V, et al. Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS ONE. 2011;6:e15640 pubmed publisher
    ..we employed immunoaffinity profiling coupled to mass spectrometry and identified DDR1, EPHA2, EGFR, and ROS tyrosine kinases, along with over 1,000 tyrosine phosphorylation sites from about 750 different proteins in primary ..
  7. Sonnenberg Riethmacher E, Walter B, Riethmacher D, Gödecke S, Birchmeier C. The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis. Genes Dev. 1996;10:1184-93 pubmed
    The c-ros gene was originally identified in mutant form as an oncogene. The proto-oncogene encodes a tyrosine kinase receptor that is expressed in a small number of epithelial cell types, including those of the epididymis...
  8. Davies K, Doebele R. Molecular pathways: ROS1 fusion proteins in cancer. Clin Cancer Res. 2013;19:4040-5 pubmed publisher
    ..b>ROS1 is a receptor tyrosine kinase that has recently been shown to undergo genetic rearrangements in a variety of human ..
  9. Xu H, Jiang W, Feng L, Liu Y, Wu P, Jiang J, et al. Dietary vitamin C deficiency depresses the growth, head kidney and spleen immunity and structural integrity by regulating NF-κB, TOR, Nrf2, apoptosis and MLCK signaling in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;52:111-38 pubmed publisher
    ..05), increased reactive oxygen species (ROS), malondialdehyde (MDA) and protein carbonyl contents (P < 0...
  10. Prasanth M, Sivamaruthi B, Chaiyasut C, Tencomnao T. A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy. Nutrients. 2019;11: pubmed publisher
    ..through absorption of energy by biomolecules, or indirectly, by increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS)...
  11. Tebay L, Robertson H, Durant S, Vitale S, Penning T, Dinkova Kostova A, et al. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic Biol Med. 2015;88:108-146 pubmed publisher
    ..It therefore plays a pivotal role in both intrinsic resistance and cellular adaptation to reactive oxygen species (ROS) and xenobiotics...
  12. Valero T. Mitochondrial biogenesis: pharmacological approaches. Curr Pharm Des. 2014;20:5507-9 pubmed
    ..Mitochondria, as the major ROS producer and the major antioxidant producer exert a crucial role within the cell mediating processes such as ..
  13. Singh D, Arya P, Sharma A, Dobhal M, Gupta R. Modulatory potential of α-amyrin against hepatic oxidative stress through antioxidant status in Wistar albino rats. J Ethnopharmacol. 2015;161:186-93 pubmed publisher
    ..mechanism related to its ability to block the P-450 mediated CCl4 bioactivation through selective inhibitors of ROS (reactive oxygen species) as antioxidants brought about significant inhibition of the formation of LPO suggesting ..
  14. Finley J. Cellular stress and AMPK links metformin and diverse compounds with accelerated emergence from anesthesia and potential recovery from disorders of consciousness. Med Hypotheses. 2019;124:42-52 pubmed publisher
    ..g. increases in calcium [Ca2+] and/or reactive oxygen species [ROS], etc.) increases lifespan and healthspan in several model organisms...
  15. Valko M, Jomova K, Rhodes C, Kuča K, Musílek K. Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Arch Toxicol. 2016;90:1-37 pubmed publisher
    ..The breakdown of metal ion homeostasis can lead to an uncontrolled formation of reactive oxygen species, ROS (via the Fenton reaction, which produces hydroxyl radicals), and reactive nitrogen species, RNS, which may cause ..
  16. Tian M, Liu F, Liu H, Zhang Q, Li L, Hou X, et al. Grape seed procyanidins extract attenuates Cisplatin-induced oxidative stress and testosterone synthase inhibition in rat testes. Syst Biol Reprod Med. 2018;64:246-259 pubmed publisher
    ..HSD3B1: 3β-hydroxysteroid dehydrogenase; CYP17A1: 17α-hydroxylase; HSD17B: 17β-hydroxysteroid dehydrogenase; ROS: reactive oxygen species; O2-: superoxide anion; H2O2: hydrogen peroxide; •OH: ..
  17. Panossian A, Seo E, Efferth T. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. Phytomedicine. 2018;50:257-284 pubmed publisher
    ..regulators FOS, FOXO6, SCX, STAT5A, ZFPM2, ZNF396, ZNF467, protein kinases MAPK10, MAPK13, MERTK, FLT1, PRKCH, ROS1, TTN), phosphatases PTPRD, PTPRR, peptidases, metabolic enzymes, a chaperone (HSPA6), and other proteins, all of ..
  18. Ansari R, Husain K, Rizvi S. Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter of Metabolism. Biomolecules. 2016;6: pubmed publisher
    ..mediated by cytochrome-P450 2E1 causes oxidative stress due to increased production of reactive oxygen species (ROS)...
  19. Zhong W, Qian K, Xiong J, Ma K, Wang A, Zou Y. Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-?B related signaling. Biomed Pharmacother. 2016;83:302-313 pubmed publisher
    ..involving 2E1 isoform of cytochrome P450/nuclear factor E2-related factor 2/reactive oxygen species (CYP2E/Nrf2/ROS) signaling pathway, as well as liver nitric oxide (NO) production in LPS-induced mice...
  20. Liu S, Feng L, Jiang W, Liu Y, Jiang J, Wu P, et al. Impact of exogenous lipase supplementation on growth, intestinal function, mucosal immune and physical barrier, and related signaling molecules mRNA expression of young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;55:88-105 pubmed publisher
    ..Moreover, optimal exogenous lipase supplementation significantly decreased reactive oxygen species (ROS), malondialdehyde (MDA) and protein carbonyl (PC) contents (P < 0...
  21. Elmallah M, Elkhadragy M, Al Olayan E, Abdel Moneim A. Protective Effect of Fragaria ananassa Crude Extract on Cadmium-Induced Lipid Peroxidation, Antioxidant Enzymes Suppression, and Apoptosis in Rat Testes. Int J Mol Sci. 2017;18: pubmed publisher
    ..Oxidative stress and elevated levels of reactive oxygen species (ROS) have recently been reported to be the main cause of cellular damage as a result of cadmium exposure...
  22. Guo Y, Jiang W, Wu P, Liu Y, Zhou X, Kuang S, et al. The decreased growth performance and impaired immune function and structural integrity by dietary iron deficiency or excess are associated with TOR, NF-?B, p38MAPK, Nrf2 and MLCK signaling in head kidney, spleen and skin of grass carp (Ctenopharyngod. Fish Shellfish Immunol. 2017;65:145-168 pubmed publisher
    ..light chain kinase (MLCK), and increased malondialdehyde (MDA), protein carbonyl (PC) and reactive oxygen species (ROS) contents in head kidney and spleen of young grass carp (P < 0...
  23. Cai H, Su S, Li Y, Zeng H, Zhu Z, Guo J, et al. Protective effects of Salvia miltiorrhiza on adenine-induced chronic renal failure by regulating the metabolic profiling and modulating the NADPH oxidase/ROS/ERK and TGF-?/Smad signaling pathways. J Ethnopharmacol. 2018;212:153-165 pubmed publisher
    ..The dichlorodihydrofluorescein diacetate (DCFH-DA) assay was used to determine the reactive oxygen species (ROS) and Western blot was applied to analyze the expression of pathogenesis-related proteins in different groups...
  24. Banerjee S, Aykin Burns N, Krager K, Shah S, Melnyk S, Hauer Jensen M, et al. Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2016;99:296-307 pubmed publisher
    Exposure of cells to ionizing radiation (IR) generates reactive oxygen species (ROS)...
  25. Pan F, Feng L, Jiang W, Jiang J, Wu P, Kuang S, et al. Methionine hydroxy analogue enhanced fish immunity via modulation of NF-?B, TOR, MLCK, MAPKs and Nrf2 signaling in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;56:208-228 pubmed publisher
    ..skin hemorrhage and lesion, LZ and ACP activities, IgM content, against malondialdehyde, protein carbonyl and ROS in the head kidney of young grass carp were 5.07, 5.21, 5.76, 5.90, 5.88, 5.80, 6.22, 5.68 and 6...
  26. Smallwood M, Nissim A, Knight A, Whiteman M, Haigh R, Winyard P. Oxidative stress in autoimmune rheumatic diseases. Free Radic Biol Med. 2018;125:3-14 pubmed publisher
    ..Oxidative stress occurs in many autoimmune diseases, along with the excess production of reactive oxygen species (ROS) and reactive nitrogen species (RNS)...
  27. Krishnaraj J, Kowshik J, Sebastian R, Raghavan S, Nagini S. Exposure to welding fumes activates DNA damage response and redox-sensitive transcription factor signalling in Sprague-Dawley rats. Toxicol Lett. 2017;274:8-19 pubmed publisher
    ..Reactive oxygen species (ROS) generation, 8-oxo-2'-deoxyguanosine (8-oxodG), xenobiotic-metabolizing enzymes (XMEs) and antioxidants were ..
  28. Ahamed M, Akhtar M, Alhadlaq H, Khan M, Alrokayan S. Comparative cytotoxic response of nickel ferrite nanoparticles in human liver HepG2 and breast MFC-7 cancer cells. Chemosphere. 2015;135:278-88 pubmed publisher
    ..oxidative stress, which was evident by the depletion of glutathione and the induction of reactive oxygen species (ROS) and lipid peroxidation. The mitochondrial membrane potential due to nickel ferrite NP exposure was also observed...
  29. Yin J, Wang A, Li W, Shi R, Jin H, Wei J. Sensitive biomarkers identification for differentiating Cd and Pb induced toxicity on zebrafish embryos. Environ Toxicol Pharmacol. 2017;56:340-349 pubmed publisher
    ..Significant increases in reactive oxygen species (ROS) production were observed in zebrafish exposed to Cd and Pb...
  30. Khapre R, Kondratova A, Susova O, Kondratov R. Circadian clock protein BMAL1 regulates cellular senescence in vivo. Cell Cycle. 2011;10:4162-9 pubmed publisher
    ..to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but ..
  31. Cheng C, Huang L, Chang Y, Hsieh C, Huang S, Hueng D. The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas. Oncotarget. 2016;7:41460-41472 pubmed publisher
    ..working mechanisms of ME2 in human GBM cell processes, including proliferation, cell cycle, invasion, migration, ROS, and ATP production. Our data demonstrated that ME2 was involved in GBM growth, invasion and migration...
  32. Baba Y, Higa J, Shimada B, Horiuchi K, Suhara T, Kobayashi M, et al. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2018;314:H659-H668 pubmed publisher
    ..2',7'-Dichlorodihydrofluorescein diacetate measurement of reactive oxygen species (ROS) production showed that erastin-induced ROS production was significantly lower in mTOR transgenic versus control ..
  33. Tseng C, Chang J, Wang J, Chang Y, Gordon M, Chao M. Protective Effects of N-Acetyl Cysteine against Diesel Exhaust Particles-Induced Intracellular ROS Generates Pro-Inflammatory Cytokines to Mediate the Vascular Permeability of Capillary-Like Endothelial Tubes. PLoS ONE. 2015;10:e0131911 pubmed publisher
    ..Previous studies using in vitro endothelial tubes as a simplified model of capillaries have found that DEP-induced ROS increase vascular permeability with rearrangement or internalization of adherens junctional VE-cadherin away from ..
  34. Thangavel S, Yoshitomi T, Sakharkar M, Nagasaki Y. Redox nanoparticle increases the chemotherapeutic efficiency of pioglitazone and suppresses its toxic side effects. Biomaterials. 2016;99:109-23 pubmed publisher
    ..nanoparticle, termed redox nanoparticle (RNP(N)) which is an effective scavenger of reactive oxygen species (ROS) as a drug carrier...
  35. Wheatley W, Kohan D. Role for reactive oxygen species in flow-stimulated inner medullary collecting duct endothelin-1 production. Am J Physiol Renal Physiol. 2017;313:F514-F521 pubmed publisher
    ..Since flow can alter nitric oxide (NO) and reactive oxygen species (ROS), both of which can affect collecting duct salt transport, we asked whether NO and/or ROS mediate flow-stimulated ..
  36. Dang L, Wang Y, Xue Y, He L, Li Y, Xiong J. Low-dose UVB irradiation prevents MMP2-induced skin hyperplasia by inhibiting inflammation and ROS. Oncol Rep. 2015;34:1478-86 pubmed publisher
    ..We found that the low-dose pre-radiated mouse skin tissue exhibited low skin inflammation, skin ROS production and consequently low skin epithelial hyperplasia after the medium-dose UV radiation compared with the no ..
  37. Cheng L, Li K, Yi N, Li X, Wang F, Xue B, et al. miRNA-141 attenuates UV-induced oxidative stress via activating Keap1-Nrf2 signaling in human retinal pigment epithelium cells and retinal ganglion cells. Oncotarget. 2017;8:13186-13194 pubmed publisher
    ..Further, UV-induced reactive oxygen species (ROS) production and cell death were significantly attenuated in miR-141-expressing RPEs and RGCs...
  38. Silihe K, Zingue S, Winter E, Awounfack C, Bishayee A, Desai N, et al. Ficus umbellata Vahl. (Moraceae) Stem Bark Extracts Exert Antitumor Activities In Vitro and In Vivo. Int J Mol Sci. 2017;18: pubmed publisher
    ..Cell cycle, apoptosis, cell migration/invasion, levels of reactive oxygen species (ROS), mitochondrial membrane potential (MMP), caspases activities as well as Bcl-2 and Bcl-xL protein content were ..
  39. Chen T, Zhang Y, Shang Y, Gu X, Zhu Y, Zhu L. NBD-BPEA regulates Zn2+- or Cu2+-induced Aβ40 aggregation and cytotoxicity. Food Chem Toxicol. 2018;119:260-267 pubmed publisher
    ..alleviate Zn2+- or Cu2+-Aβ40-induced neurotoxicity, suppress the intracellular ROS and protect against cell apoptosis...
  40. Wu J, Tsai H, Cheung W, Hsu C, Lin T. PPAR-γ Ameliorates Neuronal Apoptosis and Ischemic Brain Injury via Suppressing NF-κB-Driven p22phox Transcription. Mol Neurobiol. 2016;53:3626-3645 pubmed publisher
    ..NADPH oxidase (NOX) activation, a major driving force in ROS generation in the setting of reoxygenation/reperfusion, constitutes an important pathogenetic mechanism of ischemic ..
  41. Artini P, Casarosa E, Carletti E, Monteleone P, Di Noia A, Di Berardino O. In vitro effect of myo-inositol on sperm motility in normal and oligoasthenospermia patients undergoing in vitro fertilization. Gynecol Endocrinol. 2017;33:109-112 pubmed publisher
    ..abnormal seminal liquid specimens contain abnormal amounts of oxygen free radicals and reactive oxygen species (ROS), and that the use of antioxidant molecules both in vivo and in vitro leads to improvement of semen quality in ..
  42. Rogolino D, Cavazzoni A, Gatti A, Tegoni M, Pelosi G, Verdolino V, et al. Anti-proliferative effects of copper(II) complexes with hydroxyquinoline-thiosemicarbazone ligands. Eur J Med Chem. 2017;128:140-153 pubmed publisher
    ..This Cu(II) complex induced neither the production of reactive oxygen species (ROS) nor the accumulation of p53 protein, suggesting the lack of DNA damage.
  43. Yao Z, Wang A, Li Y, Cai Z, Lemaitre B, Zhang H. The dual oxidase gene BdDuox regulates the intestinal bacterial community homeostasis of Bactrocera dorsalis. ISME J. 2016;10:1037-50 pubmed publisher
    ..dysbiosis, in turn, stimulates an immune response by activating BdDuox and promoting reactive oxygen species (ROS) production that regulates the composition and structure of the gut bacterial community to normal status by ..
  44. González Garcinuño Á, Sánchez Álvarez J, Galán M, Martin Del Valle E. Understanding and optimizing the addition of phytohormones in the culture of microalgae for lipid production. Biotechnol Prog. 2016;32:1203-1211 pubmed publisher
    ..the microalgae in the presence of the phytohormones was due to a reduction in the level of reactive oxygen species (ROS) in the cells...
  45. Wang B, Zhou T, Nie C, Wan D, Zheng S. Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer. Biochem Biophys Res Commun. 2018;499:156-163 pubmed publisher
    ..the induction of apoptosis and autophagy were eliminated by the pretreatment of reactive oxygen species (ROS) scavenger N-acetyl-l-cysteine (NAC), suggesting that ROS played an important role in the regulation of BigV-..
  46. Tricarico P, de Oliveira França R, Pacor S, Ceglia V, Crovella S, Celsi F. HIV Protease Inhibitors Apoptotic Effect in SH-SY5Y Neuronal Cell Line. Cell Physiol Biochem. 2016;39:1463-70 pubmed publisher
    ..with MTT cell proliferation assay; mRNA expression of heme oxygenase (HemeOH) and reactive oxygen species (ROS) levels with 2',7'-dichlorofluorescin diacetate (H2DCFDA) in order to assess oxidative stress; apoptotic cell death ..
  47. Barlow J, Jensen V, Jastroch M, Affourtit C. Palmitate-induced impairment of glucose-stimulated insulin secretion precedes mitochondrial dysfunction in mouse pancreatic islets. Biochem J. 2016;473:487-96 pubmed publisher
    ..Equally, mitochondrial lipid oxidation and production of reactive oxygen species (ROS) do not contribute to increased basal insulin secretion...
  48. Wang Y, Chang J, Li X, Pathak R, Sridharan V, Jones T, et al. Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice. PLoS ONE. 2017;12:e0189466 pubmed publisher
    ..effects of 16O irradiation on HSCs coincided with an increased intracellular production of reactive oxygen species (ROS)...
  49. Chang J, Kuo H, Chang K, Kong Z. Apoptosis of Hepatocellular Carcinoma Cells Induced by Nanoencapsulated Polysaccharides Extracted from Antrodia Camphorata. PLoS ONE. 2015;10:e0136782 pubmed publisher
    ..ACE/CS and ACE/S could also increase reactive oxygen species (ROS) generation, induce Fas/APO-1 (apoptosis antigen 1) expression and elevate the proteolytic activities of caspase-3, ..
  50. Gao X, Zhu S, Xiang W, Huang K, Hu Y, Gu Y, et al. Prolonged hypothermia exposure diminishes neuroprotection for severe ischemic-hypoxic primary neurons. Cryobiology. 2016;72:141-7 pubmed publisher
    ..parts which are associated with mitochondrial apoptosis pathway: intracellular calcium, reactive oxygen species (ROS), and mitochondrial transmembrane potential (MTP)...
  51. Chu P, Han G, Ahsan A, Sun Z, Liu S, Zhang Z, et al. Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-?B pathway. Vascul Pharmacol. 2017;91:26-35 pubmed publisher
    ..Apoptotic-related proteins were evaluated by Western blotting. Reactive oxygen species (ROS) generation, intracellular calcium and mitochondrial membrane potential (MMP) were measured with fluorescent probes...
  52. Szuba A, Lorenc Plucińska G. Field proteomics of Populus alba grown in a heavily modified environment - An example of a tannery waste landfill. Sci Total Environ. 2018;610-611:1557-1571 pubmed publisher
    ..landfill-grown plants produced strong proteomic stress signals for protection against reactive oxygen species (ROS) and repair to ROS-damaged proteins and DNA as well as signals for protection of the photosynthetic apparatus...
  53. Badr G, Ramadan N, Abdel Tawab H, Ahmed S, Mahmoud M. Camel whey protein protects lymphocytes from apoptosis via the PI3K-AKT, NF-κB, ATF-3, and HSP-70 signaling pathways in heat-stressed male mice. Biochem Cell Biol. 2018;96:407-416 pubmed publisher
    ..The HS group exhibited elevated levels of reactive oxygen species (ROS) and pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, tumor necrosis factor-α) as well as a significant ..
  54. Eliyahu E, Rog I, Inbal D, Danon A. ACHT4-driven oxidation of APS1 attenuates starch synthesis under low light intensity in Arabidopsis plants. Proc Natl Acad Sci U S A. 2015;112:12876-81 pubmed publisher
    The regulatory mechanisms that use signals of low levels of reactive oxygen species (ROS) could be obscured by ROS produced under stress and thus are better investigated under homeostatic conditions...
  55. Feniouk B, Skulachev V. Cellular and Molecular Mechanisms of Action of Mitochondria-Targeted Antioxidants. Curr Aging Sci. 2017;10:41-48 pubmed
    ..A simple hypothesis that aging results from gradual accumulation of occasional damage inflicted by ROS to DNA, proteins and lipids is apparently insufficient...
  56. Nagaraj C, Haitchi H, Heinemann A, Howarth P, Olschewski A, Marsh L. Increased Expression of p22phox Mediates Airway Hyperresponsiveness in an Experimental Model of Asthma. Antioxid Redox Signal. 2017;27:1460-1472 pubmed publisher
    Chronic airway diseases such as asthma are associated with increased production of reactive oxygen species (ROS) and oxidative stress...
  57. Bazylko A, Borzym J, Parzonko A. Determination of in vitro antioxidant and UV-protecting activity of aqueous and ethanolic extracts from Galinsoga parviflora and Galinsoga quadriradiata herb. J Photochem Photobiol B. 2015;149:189-95 pubmed publisher
    ..extracts derived from the Galinsoga herb as potential photoprotectors, as the role of reactive oxygen species (ROS) has implicated in skin damage...
  58. Sareila O, Hagert C, Rantakari P, Poutanen M, Holmdahl R. Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes. PLoS ONE. 2015;10:e0141974 pubmed publisher
    ..Defects in NCF1 lead to lower production of reactive oxygen species (ROS) associated with autoimmune diseases in humans...
  59. Keshtzar E, Khodayar M, Javadipour M, Ghaffari M, Bolduc D, Rezaei M. Ellagic acid protects against arsenic toxicity in isolated rat mitochondria possibly through the maintaining of complex II. Hum Exp Toxicol. 2016;35:1060-72 pubmed publisher
    ..Reactive oxygen species (ROS) and mitochondrial membrane potential decline were assayed using dichlorofluorescein diacetate and rhodamine 123, ..
  60. Prow T, Sundh D, Lutty G. Nanoscale biosensor for detection of reactive oxygen species. Methods Mol Biol. 2013;1028:3-14 pubmed publisher
    Noninvasive detection of biological responses to reactive oxygen species (ROS) in vivo could shed light on mechanisms at work in diverse areas like developmental dynamics, therapeutic effectiveness, drug discovery, pathogenic processes, ..
  61. Wang T, Zhu M, He Z. Low-Molecular-Weight Fucoidan Attenuates Mitochondrial Dysfunction and Improves Neurological Outcome After Traumatic Brain Injury in Aged Mice: Involvement of Sirt3. Cell Mol Neurobiol. 2016;36:1257-1268 pubmed
    ..In addition, LMWF significantly suppressed protein carbonyl, lipid peroxidation, reactive oxygen species (ROS) generation, as well as mitochondrial dysfunction, which was evidenced by mitochondrial cytochrome c release and ..
  62. Silva L, Pessoa M, Alves S, Venugopal J, Cortes V, Santos H, et al. Differences of lipid membrane modulation and oxidative stress by digoxin and 21-benzylidene digoxin. Exp Cell Res. 2017;359:291-298 pubmed publisher
    ..As CTS may generate reactive oxygen species (ROS) which can affect plasma membrane fluidity and therefore Na,K-ATPase activity, several markers involved in ROS ..
  63. Caioli S, Candelotti E, Pedersen J, Saba L, Antonini A, Incerpi S, et al. Baicalein reverts L-valine-induced persistent sodium current up-modulation in primary cortical neurons. Biochim Biophys Acta. 2016;1862:566-575 pubmed publisher
    ..aim of this study was to analyze both whether high BCAA concentrations in neurons induce reactive oxygen species (ROS) production and whether, by performing electrophysiological recordings, the neuronal functional properties are ..
  64. Gandara A, Torres A, Bahia A, Oliveira P, Schama R. Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase. BMC Evol Biol. 2017;17:92 pubmed publisher
    NADPH oxidases (NOX) are ROS producing enzymes that perform essential roles in cell physiology, including cell signaling and antimicrobial defense. This gene family is present in most eukaryotes, suggesting a common ancestor...
  65. Ju S, Jo Y, Jeon Y, Pae H, Kang D, Lee H, et al. Phosphorylation of eIF2? suppresses cisplatin-induced p53 activation and apoptosis by attenuating oxidative stress via ATF4-mediated HO-1 expression in human renal proximal tubular cells. Int J Mol Med. 2017;40:1957-1964 pubmed publisher
    ..renal proximal tubular cells against cisplatin-induced apoptosis through inhibition of reactive oxygen species (ROS)?mediated p53 activation...
  66. Duan J, Kodali V, Gaffrey M, Guo J, Chu R, Camp D, et al. Quantitative Profiling of Protein S-Glutathionylation Reveals Redox-Dependent Regulation of Macrophage Function during Nanoparticle-Induced Oxidative Stress. ACS Nano. 2016;10:524-38 pubmed publisher
    ..which induce low, moderate, and high propensity, respectively, to stimulate cellular reactive oxygen species (ROS) and disrupt macrophage function...
  67. Zhang W, Song Z, Bao Y, Li W, Yang X, Wang Q, et al. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models. Biochem Pharmacol. 2016;105:66-79 pubmed publisher
    ..Furthermore, the ROS levels were elevated in the periplogenin-treated cells, NAC (an antioxidant) and Nec-1 could inhibit the ROS levels,..
  68. Kuroda A, Hegab A, Jingtao G, Yamashita S, Hizawa N, Sakamoto T, et al. Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung. Respir Res. 2017;18:69 pubmed publisher
    ..Aldh2 -/- tracheal and lung cells showed higher ROS levels and fewer functional mitochondria than those from WT mice...
  69. Song J, Kang J, Lin B, Li J, Zhu Y, Du J, et al. Mediating Role of TRPV1 Ion Channels in the Co-exposure to PM2.5 and Formaldehyde of Balb/c Mice Asthma Model. Sci Rep. 2017;7:11926 pubmed publisher
    ..5 or FA alone, the co-exposure showed a certain synergistic effect. Increased levels of ROS, inflammatory factors and total serum immunoglobulin E were concomitant with this deterioration...
  70. Xu Y, Li Y, Ma L, Xin G, Wei Z, Zeng Z, et al. d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions. Toxicol Lett. 2018;289:99-106 pubmed publisher
    ..we found that d-gal induced mitochondrial dysfunctions of LECs through increasing reactive oxygen species (ROS), reducing ATP synthesis and mitochondrial potential (MMP), enhancing the concentration of cytoplasm Ca2+..
  71. Kim J, Jung E, Moon S, Seo M. Protective effect of carbenoxolone on ER stress-induced cell death in hypothalamic neurons. Biochem Biophys Res Commun. 2015;468:793-9 pubmed publisher
    ..attenuated tunicamycin induced ER stress-mediated molecules such as spliced XBP1, ATF4, ATF6, CHOP, and ROS generation...
  72. Mytych J, Wos I, Solek P, Koziorowski M. Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes. Exp Cell Res. 2017;350:358-367 pubmed publisher
    ..co-culture model with LPS-activated and Dox-induced senescent THP-1 monocytes, we reported for the first time ROS-induced DNA damage, reduced metabolic activity, proliferation inhibition and cell cycle arrest followed by p16-, ..
  73. Hossain M, Elsayed A, Moore M, Dietz K. Redox and Reactive Oxygen Species Network in Acclimation for Salinity Tolerance in Sugar Beet. J Exp Bot. 2017;68:1283-1298 pubmed publisher
    ..to NaCl stress by maintaining its growth rate and adjusting its cellular redox and reactive oxygen species (ROS) network...
  74. Lee S, Cha H, Lee S, Kim H, Ku H, Kim S, et al. Idh2 deficiency accelerates renal dysfunction in aged mice. Biochem Biophys Res Commun. 2017;493:34-39 pubmed publisher
    ..that senescence is due to an accumulation of cellular oxidative damage, caused largely by reactive oxygen species (ROS) that are produced as by-products of normal metabolic processes in mitochondria...
  75. Jassinskaja M, Johansson E, Kristiansen T, Åkerstrand H, Sjöholm K, Hauri S, et al. Comprehensive Proteomic Characterization of Ontogenic Changes in Hematopoietic Stem and Progenitor Cells. Cell Rep. 2017;21:3285-3297 pubmed publisher
    ..characteristics include an arsenal of proteins linked to viral and bacterial defense, as well as protection against ROS-induced protein oxidation...
  76. Um J, Kim E, Lee W, Kang N, Han E, Oh J, et al. Protective Effects of An Enzymatic Hydrolysate from Octopus ocellatus Meat against Hydrogen Peroxide-Induced Oxidative Stress in Chang Liver Cells and Zebrafish Embryo. Adv Exp Med Biol. 2017;975 Pt 1:603-620 pubmed publisher
    ..OOMAH reduced the production of reactive oxygen species (ROS) in H2O2-treated hepatocytes without cytotoxicity...
  77. Singh R, Parihar P, Singh S, Mishra R, Singh V, Prasad S. Reactive oxygen species signaling and stomatal movement: Current updates and future perspectives. Redox Biol. 2017;11:213-218 pubmed publisher
    Reactive oxygen species (ROS), a by-product of aerobic metabolism were initially studied in context to their damaging effect but recent decades witnessed significant advancements in understanding the role of ROS as signaling molecules...
  78. Conley S, Abais Battad J, Yuan X, Zhang Q, Boini K, Li P. Contribution of guanine nucleotide exchange factor Vav2 to NLRP3 inflammasome activation in mouse podocytes during hyperhomocysteinemia. Free Radic Biol Med. 2017;106:236-244 pubmed publisher
    NADPH oxidase (NOX)-derived reactive oxygen species (ROS) have been demonstrated to mediate the activation of NOD-like receptor protein 3 (NLRP3) inflammasomes in podocytes in response to elevated levels of homocysteine (Hcys)...
  79. Ma Z, Yang Y, Di S, Feng X, Liu D, Jiang S, et al. Pterostilbene exerts anticancer activity on non-small-cell lung cancer via activating endoplasmic reticulum stress. Sci Rep. 2017;7:8091 pubmed publisher
    ..and adhesive abilities, downregulation of intracellular glutathione (GSH) level, enhanced reactive oxygen species (ROS) generation, Caspase 3 activity and mitochondrial membrane depolarization were observed in NSCLC cells treated with ..
  80. Li J, Zhang Y, Cai X, Xia Q, Chen J, Liao Y, et al. All-trans-retinal dimer formation alleviates the cytotoxicity of all-trans-retinal in human retinal pigment epithelial cells. Toxicology. 2016;371:41-48 pubmed publisher
    ..The latter could provoke intracellular reactive oxygen species (ROS) overproduction, increase the mRNA expression of several oxidative stress related genes (Nrf2, HO-1, and ?-GCSh), ..
  81. Fujii M, Otani E. Photochemical generation and decay kinetics of superoxide and hydrogen peroxide in the presence of standard humic and fulvic acids. Water Res. 2017;123:642-654 pubmed publisher
    Reactive oxygen species (ROS) such as superoxide (O2-) and hydrogen peroxide (H2O2) can be photochemically generated in aerobic waters containing natural organic matters (NOM) such as humic ..
  82. Bastow E, Bych K, Crack J, Le Brun N, Balk J. NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulphur proteins in Arabidopsis thaliana. Plant J. 2017;89:590-600 pubmed publisher
    ..The DNA glycosylase ROS1 was only partially decreased in activity and xanthine dehydrogenase not at all...
  83. Verma N, Tiku A. Significance and nature of bystander responses induced by various agents. Mutat Res. 2017;773:104-121 pubmed publisher
    ..The nature of bystander signal/s is not yet clear. However, there are evidences suggesting involvement of ROS, RNS, protein factors and even DNA molecules leading to the activation of a number of signaling pathways...
  84. Lewies A, Wentzel J, Miller H, du Plessis L. The antimicrobial peptide nisin Z induces selective toxicity and apoptotic cell death in cultured melanoma cells. Biochimie. 2018;144:28-40 pubmed publisher
    ..malignant cells present with altered energy metabolism which is associated with elevated reactive oxygen species (ROS) generation. This is also evident for melanoma, the leading cause of skin cancer related deaths...
  85. Angelova P, Barilani M, Lovejoy C, Dossena M, Vigano M, Seresini A, et al. Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation. Redox Biol. 2018;14:474-484 pubmed publisher
    ..Furthermore, mitochondrial dysfunction in PSP-MSCs led to a significant increase in mitochondrial ROS generation and oxidative stress, which resulted in decrease of major cellular antioxidant GSH...
  86. Meseguer S, Boix O, Navarro González C, Villarroya M, Boutoual R, Emperador S, et al. microRNA-mediated differential expression of TRMU, GTPBP3 and MTO1 in cell models of mitochondrial-DNA diseases. Sci Rep. 2017;7:6209 pubmed publisher
    ..expression of TRMU, GTPBP3 and MTO1 is regulated by different miRNAs, which are induced by retrograde signals like ROS and Ca2+ via different pathways...
  87. Huo T, Dong F, Deng J, Zhang Q, Ye W, Zhang W, et al. In vitro genotoxicity of asbestos substitutes induced by coupled stimulation of dissolved high-valence ions and oxide radicals. Environ Sci Pollut Res Int. 2018;25:22356-22367 pubmed publisher
    ..Accumulated mechanical and radical stimulation induced the intracellular reactive oxygen species (ROS) elevation, morphology change, and deviating trans-membrane ion flux...
  88. Song P, Wang Z, Zhang X, Fan J, Li Y, Chen Q, et al. The role of autophagy in asparaginase-induced immune suppression of macrophages. Cell Death Dis. 2017;8:e2721 pubmed publisher
    ..We reported here that asparaginase disturbed the function of macrophages including phagocytosis, proliferation, ROS and nitric oxide secretion, interleukin 6 (IL-6) and tumor necrosis factor ? (TNF-?) secretion, and major ..
  89. Andrienko T, Pasdois P, Pereira G, Ovens M, Halestrap A. The role of succinate and ROS in reperfusion injury - A critical appraisal. J Mol Cell Cardiol. 2017;110:1-14 pubmed publisher
    ..In addition, measurement of intracellular reactive oxygen species (ROS) during reperfusion using surface fluorescence and mitochondrial aconitase activity detected major increases in ROS ..
  90. Zai W, Chen W, Luan J, Fan J, Zhang X, Wu Z, et al. Dihydroquercetin ameliorated acetaminophen-induced hepatic cytotoxicity via activating JAK2/STAT3 pathway and autophagy. Appl Microbiol Biotechnol. 2018;102:1443-1453 pubmed publisher
    ..In addition, reactive oxygen species (ROS) accumulation and mitochondria dysfunction were also reversed by DHQ treatment...
  91. Pedone D, Moglianetti M, De Luca E, Bardi G, Pompa P. Platinum nanoparticles in nanobiomedicine. Chem Soc Rev. 2017;46:4951-4975 pubmed publisher
    ..candidates, showing remarkable catalytic activity, able to reduce the intracellular reactive oxygen species (ROS) levels and impair the downstream pathways leading to inflammation...
  92. Jalouli M, Mokas S, Turgeon C, Lamalice L, Richard D. Selective HIF-1 Regulation under Nonhypoxic Conditions by the p42/p44 MAP Kinase Inhibitor PD184161. Mol Pharmacol. 2017;92:510-518 pubmed publisher
    ..Finally, we show that PD184161 blocked mitochondrial ROS (mtROS) production and cellular ATP levels, at the same time enhancing ascorbate availability in AngII-treated VSMC...