ROR2

Summary

Gene Symbol: ROR2
Description: receptor tyrosine kinase like orphan receptor 2
Alias: BDB, BDB1, NTRKR2, tyrosine-protein kinase transmembrane receptor ROR2, neurotrophic tyrosine kinase receptor-related 2
Species: human
Products:     ROR2

Top Publications

  1. Masiakowski P, Carroll R. A novel family of cell surface receptors with tyrosine kinase-like domain. J Biol Chem. 1992;267:26181-90 pubmed
    ..These proteins, Ror1 and Ror2, share 58% overall amino acid identity and a structure indicative of cell surface molecules...
  2. Ali B, Jeffery S, Patel N, Tinworth L, Meguid N, Patton M, et al. Novel Robinow syndrome causing mutations in the proximal region of the frizzled-like domain of ROR2 are retained in the endoplasmic reticulum. Hum Genet. 2007;122:389-95 pubmed
    b>ROR2 is a member of the cell surface receptor tyrosine kinase (RTKs) family of proteins and is involved in the developmental morphogenesis of the skeletal, cardiovascular and genital systems...
  3. Schwarzer W, Witte F, Rajab A, Mundlos S, Stricker S. A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes. Hum Mol Genet. 2009;18:4013-21 pubmed publisher
    Mutations in ROR2 cause dominant brachydactyly type B (BDB1) or recessive Robinow syndrome (RRS), each characterized by a distinct combination of phenotypic features. We here report a novel nonsense mutation in ROR2 (c.1324C>T; p...
  4. van Bokhoven H, Celli J, Kayserili H, van Beusekom E, Balci S, Brussel W, et al. Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome. Nat Genet. 2000;25:423-6 pubmed
    ..9-cM interval. The gene ROR2, which encodes an orphan membrane-bound tyrosine kinase, maps to this region...
  5. Lu B, Wang Y, Wei X, Rong L, Wei D, Yan C, et al. Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma. Mol Med Rep. 2012;5:1033-6 pubmed publisher
    ..We investigated two potential markers, WNT-5a and ROR2, which are hypothesized to dysregulate WNT signaling pathways to promote tumorigenesis in other types of cancer...
  6. Liu Y, Ross J, Bodine P, Billiard J. Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. Mol Endocrinol. 2007;21:3050-61 pubmed
    b>Ror2 receptor plays a key role in bone formation, but its signaling pathway is not completely understood. We demonstrate that Ror2 homodimerizes at the cell surface, and that dimerization can be induced by a bivalent antibody...
  7. Oldridge M, Fortuna A, Maringa M, Propping P, Mansour S, Pollitt C, et al. Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B. Nat Genet. 2000;24:275-8 pubmed
    ..5 cM (refs 9,10). Here we describe mutations in ROR2, which encodes the orphan receptor tyrosine kinase ROR2 (ref. 11), in three unrelated families with BDB1...
  8. Afzal A, Rajab A, Fenske C, Oldridge M, Elanko N, Ternes Pereira E, et al. Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nat Genet. 2000;25:419-22 pubmed
    ..The recent identification of ROR2, encoding an orphan receptor tyrosine kinase, as the gene mutated in brachydactyly type B (BDB1; ref...
  9. Wright T, Brannon A, Gordan J, Mikels A, Mitchell C, Chen S, et al. Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma. Oncogene. 2009;28:2513-23 pubmed publisher
    ..Here, we report the identification of the RTK-like orphan receptor 2 (Ror2), a new tumor-associated kinase in RCC cell lines and primary tumors...

More Information

Publications87

  1. Afzal A, Jeffery S. One gene, two phenotypes: ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B. Hum Mutat. 2003;22:1-11 pubmed
    ..heterozygous mutations in ROR2 have recently been shown to give rise to autosomal dominant brachydactyly type B1 (BDB1). This condition is characterized by terminal deficiency of fingers and toes...
  2. Billiard J, Way D, Seestaller Wehr L, Moran R, Mangine A, Bodine P. The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells. Mol Endocrinol. 2005;19:90-101 pubmed
    b>Ror2 is an orphan receptor tyrosine kinase that plays crucial roles in developmental morphogenesis, particularly of the skeleton...
  3. Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis M, et al. Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol Biol. 2008;9:11 pubmed publisher
    ..Multiple receptors, including Fzds, Lrps, Ror2 and Ryk, are involved in Wnt signaling. Ror2 is a single-span transmembrane receptor-tyrosine kinase (RTK)...
  4. Yamagata K, Li X, Ikegaki S, Oneyama C, Okada M, Nishita M, et al. Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression. J Biol Chem. 2012;287:1588-99 pubmed publisher
    It has been shown that constitutively active Wnt5a-Ror2 signaling in osteosarcoma cell lines plays crucial roles in induced expression of matrix metalloproteinase-13 (MMP-13), required for their invasiveness; however, it remains largely ..
  5. Liu Y, Bhat R, Seestaller Wehr L, Fukayama S, Mangine A, Moran R, et al. The orphan receptor tyrosine kinase Ror2 promotes osteoblast differentiation and enhances ex vivo bone formation. Mol Endocrinol. 2007;21:376-87 pubmed
    b>Ror2 is a receptor tyrosine kinase, the expression of which increases during differentiation of pluripotent stem cells to osteoblasts and then declines as cells progress to osteocytes...
  6. Lara E, Calvanese V, Huidobro C, Fernandez A, Moncada Pazos A, Obaya A, et al. Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer. Mol Cancer. 2010;9:170 pubmed publisher
    ..Here we report that the receptor tyrosine kinase-like orphan receptor 2 (ROR2), a transmembrane receptor for Wnt factors that activates non-canonical pathways, is frequently repressed by ..
  7. Schwabe G, Tinschert S, Buschow C, Meinecke P, Wolff G, Gillessen Kaesbach G, et al. Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B. Am J Hum Genet. 2000;67:822-31 pubmed
    ..Recently, heterozygous mutations of the orphan receptor tyrosine kinase (TK) ROR2, located within a distinct segment directly after the TK domain, have been shown to be responsible for BDB...
  8. Akbarzadeh S, Wheldon L, Sweet S, Talma S, Mardakheh F, Heath J. The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src. PLoS ONE. 2008;3:e1873 pubmed publisher
    The transmembrane receptor 'ROR2' resembles members of the receptor tyrosine kinase family of signalling receptors in sequence but its' signal transduction mechanisms remain enigmatic...
  9. Patton M, Afzal A. Robinow syndrome. J Med Genet. 2002;39:305-10 pubmed
    ..The gene for the autosomal recessive form was identified as the ROR2 gene on chromosome 9q22. ROR2 is a receptor tyrosine kinase with orthologues in mouse and other species...
  10. O Connell M, Fiori J, Xu M, Carter A, Frank B, Camilli T, et al. The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene. 2010;29:34-44 pubmed publisher
    ..Here we show, for the first time, the importance of the orphan tyrosine kinase receptor, ROR2, in melanoma progression...
  11. Enomoto M, Hayakawa S, Itsukushima S, Ren D, Matsuo M, Tamada K, et al. Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling. Oncogene. 2009;28:3197-208 pubmed publisher
    The receptor tyrosine kinase Ror2 regulates cell migration by acting as a receptor or co-receptor for Wnt5a...
  12. Edris B, Espinosa I, Mühlenberg T, Mikels A, Lee C, Steigen S, et al. ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour. J Pathol. 2012;227:223-33 pubmed publisher
    ..An initial screen of gene expression data for 48 RTKs in 148 sarcomas showed that ROR2 was expressed in a subset of leiomyosarcoma (LMS), gastrointestinal stromal tumour (GIST) and desmoid-type ..
  13. Ford C, Qian Ma S, Quadir A, Ward R. The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis. Int J Cancer. 2013;133:779-87 pubmed publisher
    ..The recent discovery that the ROR2 receptor tyrosine kinase (RTK) is a novel Wnt receptor provides the potential to target the non-canonical Wnt ..
  14. Brunetti Pierri N, del Gaudio D, Peters H, Justino H, Ott C, Mundlos S, et al. Robinow syndrome: phenotypic variability in a family with a novel intragenic ROR2 mutation. Am J Med Genet A. 2008;146A:2804-9 pubmed publisher
    ..molecular findings of two sib pairs from the same extended family with Robinow syndrome due to a novel intragenic ROR2 deletion involving exons 6 and 7 that could not be detected by sequencing...
  15. O Connell M, Marchbank K, Webster M, Valiga A, Kaur A, Vultur A, et al. Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2. Cancer Discov. 2013;3:1378-93 pubmed publisher
    ..can be guided by changes in expression of receptors involved in the noncanonical Wnt5A signaling pathway, ROR1 and ROR2. ROR1 and ROR2 are inversely expressed in melanomas and negatively regulate each other...
  16. Morioka K, Tanikawa C, Ochi K, Daigo Y, Katagiri T, Kawano H, et al. Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Sci. 2009;100:1227-33 pubmed publisher
    ..by cDNA microarray analysis and found transactivation of receptor tyrosine kinase-like orphan receptor 2 (ROR2) expression in the majority of osteosarcoma samples...
  17. Ren D, Minami Y, Nishita M. Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition. Genes Cells. 2011;16:304-15 pubmed publisher
    ..Expression of Wnt5a, its receptor Ror2 and matrix metalloproteinase (MMP)-2 is induced in Snail/A431, but not in control A431 cells...
  18. Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, et al. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells. 2003;8:645-54 pubmed
    b>Ror2 is an orphan receptor, belonging to the Ror family of receptor tyrosine kinases. Although Ror2 has been shown to play crucial roles in developmental morphogenesis, the precise signalling events that Ror2 mediates remain elusive...
  19. Liu Y, Rubin B, Bodine P, Billiard J. Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase. J Cell Biochem. 2008;105:497-502 pubmed publisher
    ..More recently, both canonical and non-canonical Wnts were shown to bind the Ror2 receptor tyrosine kinase...
  20. Han F, Konkalmatt P, Chen J, Gildea J, Felder R, Jose P, et al. MiR-217 mediates the protective effects of the dopamine D2 receptor on fibrosis in human renal proximal tubule cells. Hypertension. 2015;65:1118-25 pubmed publisher
    ..In cells carrying D2R wild-type, Wnt5a treatment increased TGFβ1 while silencing Ror2, a Wnt5a receptor, decreased TGFβ1 and blunted the Wnt5a-induced increase in cells carrying D2R wild-type...
  21. Gröschel C, Aggarwal A, Tennakoon S, Höbaus J, Prinz Wohlgenannt M, Marian B, et al. Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells. J Steroid Biochem Mol Biol. 2016;155:224-30 pubmed publisher
    ..In healthy colon of mice fed with high vitamin D diet, the mRNA levels of Wnt5a and ROR2, that promote degradation of β-catenin, were upregulated whereas β-catenin and TCF4 protein expression were ..
  22. Baker L, Rosa G, Hao Z, Piazza A, Hoffman C, Binversie E, et al. Multivariate genome-wide association analysis identifies novel and relevant variants associated with anterior cruciate ligament rupture risk in the dog model. BMC Genet. 2018;19:39 pubmed publisher
    ..A locus on Chr1 associated with both ACLR and rTTW is located within ROR2, a gene important for cartilage and bone development...
  23. Lee S, Yi J, Bae W, Lee S, Cha H, Kim E. Thymosin Beta-4 Suppresses Osteoclastic Differentiation and Inflammatory Responses in Human Periodontal Ligament Cells. PLoS ONE. 2016;11:e0146708 pubmed publisher
    ..In addition, H2O2 up-regulated Wnt5a and its cell surface receptors, Frizzled and Ror2 in PDLCs...
  24. Lee M, Ratner N, Yutzey K. Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells. BMC Genomics. 2014;15:821 pubmed publisher
    ..detected for six binding regions in all tissue types, and Twist1-binding sequences associated with Chst11, Litaf, Ror2, and Spata5 also bound the potential Twist1 cofactor RREB1...
  25. Kim K, Hyun Y, Hewage S, Piao M, Kang K, Kang H, et al. 3-Bromo-4,5-dihydroxybenzaldehyde Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes. Mar Drugs. 2017;15: pubmed publisher
    A natural bromophenol found in seaweeds, 3-bromo-4,5-dihydroxybenzaldehyde (BDB), has been shown to possess antioxidant effects. This study aimed to investigate the mechanism by which BDB protects skin cells subjected to oxidative stress...
  26. Conte D, Garaffo G, Lo Iacono N, Mantero S, Piccolo S, Cordenonsi M, et al. The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand. Hum Mol Genet. 2016;25:740-54 pubmed publisher
    ..Wnt signaling, considering that Dwnt-5 is a target of distalless in Drosophila and the knockout of Wnt5, Ryk, Ror2 and Vangl2 in the mouse causes severe limb malformations...
  27. Henry C, Llamosas E, Daniels B, Coopes A, Tang K, Ford C. ROR1 and ROR2 play distinct and opposing roles in endometrial cancer. Gynecol Oncol. 2018;148:576-584 pubmed publisher
    In recent years, the Wnt signalling pathway and the ROR1 and ROR2 receptors have been implicated in a range of gynecological cancers...
  28. Uehara S, Udagawa N, Mukai H, Ishihara A, Maeda K, Yamashita T, et al. Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling. Sci Signal. 2017;10: pubmed publisher
    ..We delineated the pathway through which Wnt5a signaling through receptor tyrosine kinase-like orphan receptor 2 (Ror2) promoted the bone-resorbing activity of osteoclasts...
  29. Nishita M, Park S, Nishio T, Kamizaki K, Wang Z, Tamada K, et al. Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness. Sci Rep. 2017;7:1 pubmed publisher
    Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion...
  30. Wallkamm V, Rahm K, Schmoll J, Kaufmann L, Brinkmann E, Schunk J, et al. Regulation of distinct branches of the non-canonical Wnt-signaling network in Xenopus dorsal marginal zone explants. BMC Biol. 2016;14:55 pubmed publisher
    ..branches of this Wnt-signaling network, including the canonical Wnt/β-catenin and the non-canonical Wnt/PCP, Wnt/Ror2 and Wnt/Ca(2+) pathways, are assigned to distinct developmental processes and are triggered by certain ligand/..
  31. van Zuylen W, Ford C, Wong D, Rawlinson W. Human Cytomegalovirus Modulates Expression of Noncanonical Wnt Receptor ROR2 To Alter Trophoblast Migration. J Virol. 2016;90:1108-15 pubmed publisher
    ..Western blot and real-time PCR analyses show increased expression of noncanonical Wnt receptor ROR2 in CMV-infected trophoblasts...
  32. Kim T, Park J, Uhm J, Kim J, Joung B, Lee M, et al. Challenging Achievement of Bidirectional Block After Linear Ablation Affects the Rhythm Outcome in Patients With Persistent Atrial Fibrillation. J Am Heart Assoc. 2016;5: pubmed
    It is not clear whether bidirectional block (BDB) of linear ablations reduces atrial fibrillation (AF) recurrence after radiofrequency catheter ablation...
  33. Abdelhamed Z, Natarajan S, Wheway G, Inglehearn C, Toomes C, Johnson C, et al. The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway. Dis Model Mech. 2015;8:527-41 pubmed publisher
    ..developmental abnormalities in the Tmem67(tm1Dgen/H1) knockout mouse that closely resemble those seen in Wnt5a and Ror2 knockout mice...
  34. Ackers I, Szymanski C, Duckett K, Consitt L, Silver M, Malgor R. Blocking Wnt5a signaling decreases CD36 expression and foam cell formation in atherosclerosis. Cardiovasc Pathol. 2018;34:1-8 pubmed publisher
    ..receptors and noncanonical Wnt5a receptors [frizzled 5 (Fz5) and receptor tyrosine kinase-like orphan receptor 2 (Ror2)] in human atherosclerotic macrophages/foam cells...
  35. Habib R, Amin Ud Din M, Ahmad W. A nonsense mutation in the gene ROR2 underlying autosomal dominant brachydactyly type B. Clin Dysmorphol. 2013;22:47-50 pubmed publisher
    ..dominant condition characterized by terminal deficiency of the fingers and toes, results from mutations in the gene ROR2 encoding a receptor tyrosine kinase...
  36. Mei H, Lian S, Zhang S, Wang W, Mao Q, Wang H. High expression of ROR2 in cancer cell correlates with unfavorable prognosis in colorectal cancer. Biochem Biophys Res Commun. 2014;453:703-9 pubmed publisher
    The receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a transmembrane protein that belongs to a conserved family of tyrosine kinase receptors involved in several functional processes...
  37. Chen L, Zhao L, Ding M, Yang M, Yang W, Cui G, et al. Higher expression level of tyrosine kinase-like orphan receptor 2 and Wnt member 5a in papillary thyroid carcinoma is associated with poor prognosis. Oncol Lett. 2017;14:5966-5972 pubmed publisher
    The tyrosine kinase-like orphan receptor 2 (ROR2) has a wnt-mediated, pro-tumorigenic role in certain types of cancer...
  38. Kim Y, Hong M, Do I, Ha S, Lee D, Suh Y. Wnt5a, Ryk and Ror2 expression in glioblastoma subgroups. Pathol Res Pract. 2015;211:963-72 pubmed publisher
    ..We investigated the protein expression of Wnt5a, its receptors Ryk and Ror2, and the canonical Wnt pathway marker β-catenin in 186 cases of glioblastoma and its variants...
  39. Zhu A, Shen L, Xu L, Chen W, Huang Y. Wnt5a mediates chronic post-thoracotomy pain by regulating non-canonical pathways, nerve regeneration, and inflammation in rats. Cell Signal. 2018;44:51-61 pubmed publisher
    ..Increased protein levels of Wnt5a, transmembrane receptor Ror2, and activated non-canonical Wnt pathway members were found in the thoracic dorsal root ganglions from ..
  40. Roarty K, Pfefferle A, Creighton C, Perou C, Rosen J. Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression. Oncogene. 2017;36:5958-5968 pubmed publisher
    ..the topology of canonical Wnt β-catenin-dependent signaling activity and non-canonical β-catenin-independent Ror2-mediated Wnt signaling across subtypes and within tumor cell subpopulations in vivo...
  41. Wang L, Lu X, Smagghe G, Meng L, Wang J. Functional characterization of BdB1, a well-conserved carboxylesterase among tephritid fruit flies associated with malathion resistance in Bactrocera dorsalis (Hendel). Comp Biochem Physiol C Toxicol Pharmacol. 2017;200:1-8 pubmed publisher
    ..Here, we narrow this research gap by demonstrating a well-conserved esterase B1 gene, BdB1, mediates malathion resistance development via gene upregulation with the use of a laboratory selected malathion-..
  42. Aglan M, Amr K, Ismail S, Ashour A, Otaify G, Mehrez M, et al. Clinical and molecular characterization of seven Egyptian families with autosomal recessive robinow syndrome: Identification of four novel ROR2 gene mutations. Am J Med Genet A. 2015;167A:3054-61 pubmed publisher
    ..Autosomal recessive Robinow syndrome (ARRS) is caused by mutations in the ROR2 gene...
  43. Henry C, Emmanuel C, Lambie N, Loo C, Kan B, Kennedy C, et al. Distinct Patterns of Stromal and Tumor Expression of ROR1 and ROR2 in Histological Subtypes of Epithelial Ovarian Cancer. Transl Oncol. 2017;10:346-356 pubmed publisher
    The ROR1 and ROR2 receptor tyrosine kinases have both been implicated in ovarian cancer progression and have been shown to drive migration and invasion...
  44. Lyros O, Nie L, Moore T, Medda R, Otterson M, Behmaram B, et al. Dysregulation of WNT5A/ROR2 Signaling Characterizes the Progression of Barrett-Associated Esophageal Adenocarcinoma. Mol Cancer Res. 2016;14:647-59 pubmed publisher
    ..WNT5A is a noncanonical WNT, which mainly functions via the receptor tyrosine kinase-like orphan receptor 2 (ROR2), and has an unclear role in carcinogenesis...
  45. Bracuto V, Appiano M, Zheng Z, Wolters A, Yan Z, Ricciardi L, et al. Functional Characterization of a Syntaxin Involved in Tomato (Solanum lycopersicum) Resistance against Powdery Mildew. Front Plant Sci. 2017;8:1573 pubmed publisher
    Specific syntaxins, such as Arabidopsis AtPEN1 and its barley ortholog ROR2, play a major role in plant defense against powdery mildews...
  46. Kjaer K, Tiner M, Cingoz S, Karatosun V, Tommerup N, Mundlos S, et al. A novel subtype of distal symphalangism affecting only the 4th finger. Am J Med Genet A. 2009;149A:1571-3 pubmed publisher
  47. Ermakov S, Trofimov S, Malkin I, Livshits G. A significant association exists between receptor tyrosine kinase-like orphan receptor 2 gene variants and the OPG/RANKL ratio in human plasma. Osteoporos Int. 2012;23:1899-907 pubmed publisher
    There is a paucity of studies investigating association between ROR2 gene variants and osteoporosis and osteoarthritis-related phenotypes...
  48. Bacchelli C, Wilson L, Cook J, Winter R, Goodman F. ROR2 is mutated in hereditary brachydactyly with nail dysplasia, but not in Sorsby syndrome. Clin Genet. 2003;64:263-5 pubmed
  49. Bleckmann A, Conradi L, Menck K, Schmick N, Schubert A, Rietkötter E, et al. β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases. Clin Exp Metastasis. 2016;33:309-23 pubmed publisher
    ..02-4.69, p = 0.0391). This is in line with the in vitro results of the alternative WNT receptors ROR1 and ROR2, which foster invasion...
  50. Ermakov S, Malkin I, Keter M, Kobyliansky E, Livshits G. Family-based association study of ROR2 polymorphisms with an array of radiographic hand bone strength phenotypes. Osteoporos Int. 2007;18:1683-92 pubmed
    ..evidence of association of radiographic hand bone length (BL) and bone mineral density (BMD) with polymorphisms in ROR2 gene that plays important role in skeletal development...
  51. Pacheco I, Macleod R. CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia. Am J Physiol Gastrointest Liver Physiol. 2008;295:G748-59 pubmed publisher
    ..protein stimulation of CDX2 transcripts and protein and SI reporter were increased by overexpression of wild-type Ror2, a Wnt5a receptor, and reduced with siRNA against Ror2...
  52. Mazzotta S, Neves C, Bonner R, Bernardo A, Docherty K, Hoppler S. Distinctive Roles of Canonical and Noncanonical Wnt Signaling in Human Embryonic Cardiomyocyte Development. Stem Cell Reports. 2016;7:764-776 pubmed publisher
    ..WNT8A, via FZD7 and canonical signaling, regulate BRACHYURY expression and mesoderm induction; that WNT5A/5B, via ROR2 and noncanonical signaling, regulate MESP1 expression and cardiovascular development; and that later in development ..
  53. Arabzadeh S, Hossein G, Salehi Dulabi Z, Zarnani A. WNT5A-ROR2 is induced by inflammatory mediators and is involved in the migration of human ovarian cancer cell line SKOV-3. Cell Mol Biol Lett. 2016;21:9 pubmed publisher
    ..It is also highly expressed by ovarian cancer cells. ROR2, which is a member of the Ror-family of receptor tyrosine kinases, acts as a receptor or co-receptor for Wnt5A...
  54. Lu C, Wang X, Zhu H, Feng J, Ni S, Huang J. Over-expression of ROR2 and Wnt5a cooperatively correlates with unfavorable prognosis in patients with non-small cell lung cancer. Oncotarget. 2015;6:24912-21 pubmed publisher
    ..Tissue microarray-based immunohistochemical analysis was performed to determine the expression of ROR2 and Wnt5a in 219 patients...
  55. Artim S, Mendrola J, Lemmon M. Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family. Biochem J. 2012;448:213-20 pubmed publisher
    ..determined crystal structures of TKDs from TrkA (tropomyosin receptor kinase A, a nerve growth factor receptor) and Ror2 (receptor tyrosine kinase-like orphan receptor 2, an unconventional Wnt receptor)...
  56. Yu J, Chen L, Cui B, Widhopf G, Shen Z, Wu R, et al. Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation. J Clin Invest. 2016;126:585-98 pubmed
    ..Treatment of CLL cells with Wnt5a induced ROR1 to oligomerize with ROR2 and recruit guanine exchange factors (GEFs), which activated Rac1 and RhoA; siRNA-mediated silencing of either ROR1 ..
  57. Verma S, Das P. G-quadruplex structure at intron 2 of TFE3 and its role in Xp11.2 translocation and splicing. Biochim Biophys Acta Gen Subj. 2018;1862:630-636 pubmed publisher
    ..In our In silico study by QGRS mapper and non BdB web servers we found a Potential G-quadruplex forming Sequence (PQS) in the intron 2 of TFE3 gene...
  58. Paganoni S, Ferreira A. Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2. J Cell Sci. 2005;118:433-46 pubmed
    ..Here we report that the receptor tyrosine kinases Ror1 and Ror2 modulate the growth of neurites as well as their branching pattern in hippocampal neurons...
  59. Henry C, Quadir A, Hawkins N, Jary E, Llamosas E, Kumar D, et al. Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling. J Cancer Res Clin Oncol. 2015;141:243-54 pubmed publisher
    ..The recent discovery that the receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a novel Wnt receptor provides a potential new therapeutic and diagnostic target...
  60. Hasegawa D, Wada N, Yoshida S, Mitarai H, Arima M, Tomokiyo A, et al. Wnt5a suppresses osteoblastic differentiation of human periodontal ligament stem cell-like cells via Ror2/JNK signaling. J Cell Physiol. 2018;233:1752-1762 pubmed publisher
    ..analysis revealed that a Wnt5a-related receptor, receptor tyrosine kinase-like orphan receptor 2 (Ror2), was expressed in rat PDL tissue...
  61. Sakamoto T, Kawano S, Matsubara R, Goto Y, Jinno T, Maruse Y, et al. Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ?Np63?-mediated epithelial-mesenchymal transition. Oral Oncol. 2017;69:15-25 pubmed publisher
    ..Seven OSCC cell lines were used. Expression of ?Np63, Wnt5a, its receptor Ror2, and matrix metalloproteinases (MMPs) were analyzed by RT-PCR, real-time PCR, and western blotting, and gelatin ..
  62. Yuan Y, Niu C, Deng G, Li Z, Pan J, Zhao C, et al. The Wnt5a/Ror2 noncanonical signaling pathway inhibits canonical Wnt signaling in K562 cells. Int J Mol Med. 2011;27:63-9 pubmed publisher
    ..In particular, we focused on Ror2 functioning as a Wnt5a receptor to mediate noncanonical Wnt signaling, which inhibits canonical Wnt signaling in ..
  63. Yang C, Ji S, Li Y, Fu L, Jiang T, Meng F. Ror2, a Developmentally Regulated Kinase, Is Associated With Tumor Growth, Apoptosis, Migration, and Invasion in Renal Cell Carcinoma. Oncol Res. 2017;25:195-205 pubmed publisher
    ..In the present study, we investigated the receptor tyrosine kinase-like orphan receptor 2 (Ror2), a new tumor-associated kinase, in RCC primary tumors and cell lines...
  64. Henry C, Llamosas E, Knipprath Meszaros A, Schoetzau A, Obermann E, Fuenfschilling M, et al. Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion. Oncotarget. 2015;6:40310-26 pubmed publisher
    ..Here we investigated the role of two Wnt receptor tyrosine kinases (RTKs), ROR1 and ROR2, and their putative ligand, Wnt5a, in ovarian cancer...
  65. Huang J, Fan X, Wang X, Lu Y, Zhu H, Wang W, et al. High ROR2 expression in tumor cells and stroma is correlated with poor prognosis in pancreatic ductal adenocarcinoma. Sci Rep. 2015;5:12991 pubmed publisher
    RTK-like orphan receptor 2 (ROR2) is overexpressed in several cancers and has tumorigenic activity...
  66. Tamhankar P, Vasudevan L, Kondurkar S, Yashaswini K, Agarwalla S, Nair M, et al. Identification of novel ROR2 gene mutations in Indian children with Robinow syndrome. J Clin Res Pediatr Endocrinol. 2014;6:79-83 pubmed publisher
    ..Mutations in the ROR2 gene cause autosomal recessive RS (RRS) whereas mutations in WNT5A are responsible for the autosomal dominant (AD) ..
  67. Ma S, Henry C, Llamosas E, Higgins R, Daniels B, Hesson L, et al. Validation of specificity of antibodies for immunohistochemistry: the case of ROR2. Virchows Arch. 2017;470:99-108 pubmed publisher
    The Wnt signalling receptor receptor tyrosine kinase-like orphan receptor 2 (ROR2) is implicated in numerous human cancers...
  68. Saygin C, Wiechert A, Rao V, Alluri R, Connor E, Thiagarajan P, et al. CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors. J Exp Med. 2017;214:2715-2732 pubmed publisher
    ..CD55 regulated self-renewal and core pluripotency genes via ROR2/JNK signaling and in parallel cisplatin resistance via lymphocyte-specific protein tyrosine kinase (LCK) signaling, ..
  69. Takahashi D, Suzuki H, Kakei Y, Yamakoshi K, Minami Y, Komori T, et al. Expression of Ror2 associated with fibrosis of the submandibular gland. Cell Struct Funct. 2017;: pubmed publisher
    ..the SMG is ligated unilaterally to induce inflammation of the gland and examined the expression of Wnt5a, Ror1 and Ror2 genes, encoding Wnt5a ligand and its cognate receptors, which have been implicated in tissue damage or inflammatory ..
  70. Yuan Y, Call M, Yuan Y, Zhang Y, Fischesser K, Liu C, et al. Dexamethasone induces cross-linked actin networks in trabecular meshwork cells through noncanonical wnt signaling. Invest Ophthalmol Vis Sci. 2013;54:6502-9 pubmed publisher
    ..Lentivirus-based shRNA against noncanonical Wnt receptor (Ror2) was used to determine the role of noncanonical Wnt signaling in DEX-induced CLAN formation...
  71. Oldridge M, Temple I, Santos H, Gibbons R, Mustafa Z, Chapman K, et al. Brachydactyly type B: linkage to chromosome 9q22 and evidence for genetic heterogeneity. Am J Hum Genet. 1999;64:578-85 pubmed
    Brachydactyly type B (BDB), an autosomal dominant disorder, is the most severe of the brachydactylies and is characterized by hypoplasia or absence of the terminal portions of the index to little fingers, usually with absence of the ..
  72. Peng H, Nerreter T, Chang J, Qi J, Li X, Karunadharma P, et al. Mining Naïve Rabbit Antibody Repertoires by Phage Display for Monoclonal Antibodies of Therapeutic Utility. J Mol Biol. 2017;429:2954-2973 pubmed publisher
    ..Panels of rabbit mAbs selected from this library against two emerging cancer targets, ROR1 and ROR2, revealed high diversity, affinity, and specificity...
  73. Kang N, Han S, Kang H, Ko G, Yoon W, Kang H, et al. Anti-Inflammatory Effect of 3-Bromo-4,5-Dihydroxybenzaldehyde, a Component of Polysiphonia morrowii, In Vivo and In Vitro. Toxicol Res. 2017;33:325-332 pubmed publisher
    3-Bromo-4,5-dihydroxybenzaldehyde (BDB) is a natural bromophenol compound that is most commonly isolated from red algae...
  74. Rasmussen N, Wright T, Brooks S, Hacker K, Debebe Z, Sendor A, et al. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem. 2013;288:26301-10 pubmed publisher
    Expression of the receptor tyrosine kinase-like orphan receptor 2 (Ror2) has been identified in an increasing array of tumor types and is known to play a role as an important mediator of Wnt signaling cascades...
  75. Sun B, Ye X, Lin L, Shen M, Jiang T. Up-regulation of ROR2 is associated with unfavorable prognosis and tumor progression in cervical cancer. Int J Clin Exp Pathol. 2015;8:856-61 pubmed
    To investigate the clinical significance of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in cervical cancer...
  76. Wang B, Tang Z, Gong H, Zhu L, Liu X. Wnt5a promotes epithelial-to-mesenchymal transition and metastasis in non-small-cell lung cancer. Biosci Rep. 2017;37: pubmed publisher
    ..In NSCLC tissues, higher expression levels of Wnt5a and ROR2 were found, ?-Catenin was expressed exceptionally, and EMT was prompted...
  77. He L, Yang Z, Zhou J, Wang W. The clinical pathological significance of FRAT1 and ROR2 expression in cartilage tumors. Clin Transl Oncol. 2015;17:438-45 pubmed publisher
    ..This study investigated the protein expression and clinicopathological significance of ROR2 and FRAT1 in 59 chondrosarcomas and 33 osteochondromas...