ROBO2

Summary

Gene Symbol: ROBO2
Description: roundabout guidance receptor 2
Alias: SAX3, roundabout homolog 2, roundabout, axon guidance receptor, homolog 2
Species: human
Products:     ROBO2

Top Publications

  1. Liu Z, Patel K, Schmidt H, Andrews W, Pini A, Sundaresan V. Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Mol Cell Neurosci. 2004;26:232-40 pubmed
    ..We have recently demonstrated that members of the Robo family (Robo1 and Robo2) interact homophilically and heterophilically, thereby functioning to promote neurite outgrowth...
  2. Mitra S, Mazumder Indra D, Mondal R, Basu P, Roy A, Roychoudhury S, et al. Inactivation of SLIT2-ROBO1/2 pathway in premalignant lesions of uterine cervix: clinical and prognostic significances. PLoS ONE. 2012;7:e38342 pubmed publisher
    ..In CIN, SLIT2 was deleted in 22% samples compared to 9% for ROBO1 and none for ROBO2, whereas comparable methylation was observed for both SLIT2 (30%) and ROBO1 (22%) followed by ROBO2 (9%)...
  3. Kidd T, Brose K, Mitchell K, Fetter R, Tessier Lavigne M, Goodman C, et al. Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell. 1998;92:205-15 pubmed
    ..Transgenic rescue experiments reveal that Robo can function in a cell-autonomous fashion. Robo appears to function as the gatekeeper controlling midline crossing. ..
  4. Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, et al. Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1019-27 pubmed publisher
    ..We further compared the mRNA expressions of ROBO1, ROBO2, ROBO3, and ROBO4 in the lymphocytes of 19 drug-naïve autistic patients and 20 age- and sex-matched controls...
  5. Barak R, Yom Tov G, Guez Haddad J, Gasri Plotnitsky L, Maimon R, Cohen Berkman M, et al. Structural Principles in Robo Activation and Auto-inhibition. Cell. 2019;: pubmed publisher
    ..Here, we report a 3.6 Å crystal structure of the intact human Robo2 ectodomain (domains D1-8)...
  6. Gołoś A, Jesionek Kupnicka D, Gil L, Braun M, Komarnicki M, Robak T, et al. The Expression of the SLIT-ROBO Family in Adult Patients with Acute Myeloid Leukemia. Arch Immunol Ther Exp (Warsz). 2019;: pubmed publisher
    ..The paraffin-embedded tissue blocks were subjected to immunohistochemistry for SLIT1, SLIT2, SLIT3, ROBO1, ROBO2, ROBO3, and ROBO4. Microvessel density (MVD) was evaluated by CD34 immunohistochemistry...
  7. Kim H, Choi Y, Lee Y, Park S, Baek J, Kim H, et al. SLIT3 regulates endochondral ossification by β-catenin suppression in chondrocytes. Biochem Biophys Res Commun. 2018;506:847-853 pubmed publisher
    ..ATDC5 cells expressed only ROBO2 among their 4 isotypes, and the Robo2 knock-down with its siRNA reversed the SLIT3-stimulated differentiated ..
  8. Gruner H, Kim M, Mastick G. Robo1 and 2 Repellent Receptors Cooperate to Guide Facial Neuron Cell Migration and Axon Projections in the Embryonic Mouse Hindbrain. Neuroscience. 2019;402:116-129 pubmed publisher
    ..Our goal in this study was to test the functions of the chemorepulsive receptors Robo1 and Robo2 in facial neuron migration and axon projection by analyzing genetically marked motor neurons in double-mutant ..
  9. Xu R, Qin N, Xu X, Sun X, Chen X, Zhao J. Implication of SLIT3-ROBO1/ROBO2 in granulosa cell proliferation, differentiation and follicle selection in the prehierarchical follicles of hen ovary. Cell Biol Int. 2018;42:1643-1657 pubmed publisher
    ..components of the SLIT/ROBO family, serves as a ligand that potentially interacts with the four receptors, ROBO1, ROBO2, ROBO3 and ROBO4...

More Information

Publications95

  1. Pinho A, Van Bulck M, Chantrill L, Arshi M, Sklyarova T, Herrmann D, et al. ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling. Nat Commun. 2018;9:5083 pubmed publisher
    ..Here we report that in pancreatitis and PDAC mouse models, epithelial Robo2 expression is lost while Robo1 expression becomes most prominent in the stroma...
  2. Guan T, Huang K, Liu Y, Hou S, Hu C, Li Y, et al. Aristolochic acid inhibits Slit2-induced migration and tube formation via inactivation of Robo1/Robo2-NCK1/NCK2 signaling pathway in human umbilical vein endothelial cells. Toxicol Lett. 2019;300:51-58 pubmed publisher
    Robo1/Robo2-NCK1/NCK2 signaling pathway controls endothelial cell sprouting and migration induced by Slit2 or VEGF, but whether it is involved in peritubular capillary (PTC) rarefaction of Aristolochic acid nephropathy (AAN) is unclear...
  3. Yang Y, Manning Fox J, Zhang K, MacDonald P, Johnson J. Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion. Proc Natl Acad Sci U S A. 2013;110:16480-5 pubmed publisher
    ..ROBO1 and ROBO2 receptors were detected in beta and alpha cells...
  4. Tayler T, Robichaux M, Garrity P. Compartmentalization of visual centers in the Drosophila brain requires Slit and Robo proteins. Development. 2004;131:5935-45 pubmed
    ..We find that loss of Slit or simultaneous knockdown of Robo, Robo2 and Robo3 causes distal cell neurons to invade the lamina, resulting in cell mixing across the lamina/lobula ..
  5. Escot S, Willnow D, Naumann H, Di Francescantonio S, Spagnoli F. Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. Nat Commun. 2018;9:5082 pubmed publisher
    ..We find that Robo1 and Robo2 are required for preserving pancreatic cell identity shortly after fate induction and, subsequently, for expansion ..
  6. Aberg K, Shabalin A, Chan R, Zhao M, Kumar G, van Grootheest G, et al. Convergence of evidence from a methylome-wide CpG-SNP association study and GWAS of major depressive disorder. Transl Psychiatry. 2018;8:162 pubmed publisher
    ..Overlapping loci included, e.g., ROBO2, ASIC2, and DCC...
  7. Li J, Ye Y, Zhang R, Zhang L, Hu X, Han D, et al. Robo1/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice. Sci Rep. 2015;5:9720 pubmed publisher
    ..We next showed that Robo1 and Robo2 are strongly expressed in ovarian granulosa cells...
  8. Zeng Z, Wu Y, Cao Y, Yuan Z, Zhang Y, Zhang D, et al. Slit2-Robo2 signaling modulates the fibrogenic activity and migration of hepatic stellate cells. Life Sci. 2018;203:39-47 pubmed publisher
    ..The up-regulation of the ligand Slit2 and membrane receptor Robo2 genes within this pathway was further validated in TAA-induced fibrotic livers...
  9. Harburg G, Compton J, Liu W, Iwai N, Zada S, Marlow R, et al. SLIT/ROBO2 signaling promotes mammary stem cell senescence by inhibiting Wnt signaling. Stem Cell Reports. 2014;3:385-93 pubmed publisher
    ..Here, we demonstrate that SLIT2 restricts stem cell renewal by signaling through ROBO2 in a subset of basal cells to negatively regulate WNT signaling...
  10. Kawano K, Gotoh H, Nomura T, Ono K. Birthdate-dependent heterogeneity of oculomotor neurons is involved in transmedian migration in the developing mouse midbrain. J Chem Neuroanat. 2018;94:32-38 pubmed publisher
    ..On the other hand, Robo2, a receptor of Sli2, is differentially expressed in subpopulations of rostral and caudal parts of the nIII: ..
  11. Hernández Miranda L, Cariboni A, Faux C, Ruhrberg C, Cho J, Cloutier J, et al. Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain. J Neurosci. 2011;31:6174-87 pubmed publisher
    ..Cortical interneurons also express Robo receptors, and we show here that in mice lacking Robo1, but not Robo2, these cells migrate aberrantly through the striatum...
  12. Chen X, Long F, Cai B, Chen X, Chen G. A novel relationship for schizophrenia, bipolar and major depressive disorder Part 3: Evidence from chromosome 3 high density association screen. J Comp Neurol. 2018;526:59-79 pubmed publisher
    ..SNPs were systematically revealed and outstanding susceptibility genes (CADPS, GRM7,KALRN, LSAMP, NLGN1, PRICKLE2, ROBO2) were identified...
  13. Kuwako K, Okano H. The LKB1-SIK Pathway Controls Dendrite Self-Avoidance in Purkinje Cells. Cell Rep. 2018;24:2808-2818.e4 pubmed publisher
    ..plays a pivotal role in the self-avoidance of Purkinje cell (PC) dendrites by ensuring dendritic localization of Robo2, a regulator of self-avoidance...
  14. Adams M, Gilbert J, Hinojosa Paiz J, Bowman F, Blum B. Endocrine cell type sorting and mature architecture in the islets of Langerhans require expression of Roundabout receptors in β cells. Sci Rep. 2018;8:10876 pubmed publisher
    ..Mice with whole-body deletion of Robo1 and conditional deletion of Robo2 either in all endocrine cells or selectively in β cells show complete loss of endocrine cell type sorting, ..
  15. Evans T, Santiago C, Arbeille E, Bashaw G. Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons. elife. 2015;4:e08407 pubmed publisher
    ..we describe a distinct mechanism to inhibit Robo1 repulsion and promote midline crossing, in which Roundabout2 (Robo2) binds to and prevents Robo1 signaling...
  16. Stine R, Greenspan L, Ramachandran K, MATUNIS E. Coordinate regulation of stem cell competition by Slit-Robo and JAK-STAT signaling in the Drosophila testis. PLoS Genet. 2014;10:e1004713 pubmed publisher
    ..The ligand Slit is expressed specifically in hub cells while its receptor, Roundabout 2 (Robo2), is required in CySCs in order for them to compete for occupancy in the niche...
  17. Mommersteeg M, Yeh M, Parnavelas J, Andrews W. Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves. Cardiovasc Res. 2015;106:55-66 pubmed publisher
    ..Expression of Robo1 and Robo2 receptors and their ligands, Slit2 and Slit3, was present in or adjacent to all cardiac cushions/valves...
  18. Ceber M, Mihmanli A, Kilic U, Sener U, Yuksek A, Durak M, et al. Changes in expression of Slit1 and its receptor Robo2 in trigeminal ganglion and inferior alveolar nerve following inferior alveolar nerve axotomy in adult rats: a pilot study. Int J Oral Maxillofac Surg. 2015;44:518-27 pubmed publisher
    The objective of this study was to analyze changes in expression pattern of Slit1 and Robo2, and to clarify the relationship between these changes and functional recovery of the axotomized inferior alveolar nerve (IAN) without repair ..
  19. Trifonov V, Pasqualucci L, Dalla Favera R, Rabadan R. MutComFocal: an integrative approach to identifying recurrent and focal genomic alterations in tumor samples. BMC Syst Biol. 2013;7:25 pubmed publisher
    ..In addition to recapitulating known alterations, MutComFocal identifies ARID1B, ROBO2 and MRS1 as candidate tumor suppressors and KLHL6, IL31 and LRP1 as putative oncogenes in DLBCL...
  20. Rama N, Dubrac A, Mathivet T, Ní Chárthaigh R, Genet G, Cristofaro B, et al. Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization. Nat Med. 2015;21:483-91 pubmed publisher
    ..various Slit and Robo proteins and found that Slit2 potently and selectively promoted angiogenesis via Robo1 and Robo2 in mouse postnatal retina and in a model of ocular neovascular disease...
  21. Wyatt C, Ebert A, Reimer M, Rasband K, Hardy M, Chien C, et al. Analysis of the astray/robo2 zebrafish mutant reveals that degenerating tracts do not provide strong guidance cues for regenerating optic axons. J Neurosci. 2010;30:13838-49 pubmed publisher
    During formation of the optic projection in astray/robo2 mutant zebrafish, optic axons exhibit rostrocaudal pathfinding errors, ectopic midline crossing and increased terminal arbor size...
  22. Zecca A, Dyballa S, Voltes A, Bradley R, Pujades C. The Order and Place of Neuronal Differentiation Establish the Topography of Sensory Projections and the Entry Points within the Hindbrain. J Neurosci. 2015;35:7475-86 pubmed publisher
    ..Neural crest cells and repulsive slit1/robo2 signals then guide axons from later-differentiating neurons toward the neural tube...
  23. Waddell N, Pajic M, Patch A, Chang D, Kassahn K, Bailey P, et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature. 2015;518:495-501 pubmed publisher
    ..were prevalent, affecting genes known to be important in pancreatic cancer (TP53, SMAD4, CDKN2A, ARID1A and ROBO2) and new candidate drivers of pancreatic carcinogenesis (KDM6A and PREX2)...
  24. Xu R, Qin N, Xu X, Sun X, Chen X, Zhao J. Inhibitory effect of SLIT2 on granulosa cell proliferation mediated by the CDC42-PAKs-ERK1/2 MAPK pathway in the prehierarchical follicles of the chicken ovary. Sci Rep. 2018;8:9168 pubmed publisher
    ..01). However, these inhibitory effects can be abolished by the siRNA-mediated knockdown of the ROBO1 and ROBO2 receptors...
  25. Delloye Bourgeois C, Jacquier A, Charoy C, Reynaud F, Nawabi H, Thoinet K, et al. PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments. Nat Neurosci. 2015;18:36-45 pubmed publisher
    ..Slit processing generates an N-terminal fragment (SlitN) that binds to Robo1 and Robo2 receptors and mediates Slit repulsive activity, as well as a C-terminal fragment (SlitC) with an unknown receptor ..
  26. Samelson B, Gore B, Whiting J, Nygren P, Purkey A, Colledge M, et al. A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors. J Biol Chem. 2015;290:14107-19 pubmed publisher
    ..screen for additional AKAP79/150 binding partners, we have identified the Roundabout axonal guidance receptor Robo2 and its ligands Slit2 and Slit3...
  27. Suzuki T, Hasegawa E, Nakai Y, Kaido M, Takayama R, Sato M. Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center. Cell Rep. 2016;15:499-509 pubmed publisher
    ..express the repellent ligand Slit, and the two layers that the neurons intercalate between express the receptors Robo2 and Robo3...
  28. Baker N. Mechanisms of cell competition emerging from Drosophila studies. Curr Opin Cell Biol. 2017;48:40-46 pubmed publisher
    ..pre-neoplastic tumors makes use of signals and receptors also used in patterning the nervous system including Slit/Robo2 and Sas/PTP10D to recognize and extrude clones of mutant cells, at least where local epithelial cyto-architecture ..
  29. Zhang Q, Zhang H, Zhang X, Zhao J, Ma Z, Zhao D, et al. srGAP3 promotes neurite outgrowth of dorsal root ganglion neurons by inactivating RAC1. Asian Pac J Trop Med. 2014;7:630-638 pubmed publisher
    ..In this study, expression of Slit1 was observed predominantly in the glia, while expression of Robo2 and srGAP3 was detected in sensory neurons of postnatal rat cultured dorsal root ganglion (DRG)...
  30. Bhattacharya R, Mukherjee N, Dasgupta H, Islam M, Alam N, Roy A, et al. Frequent alterations of SLIT2-ROBO1-CDC42 signalling pathway in breast cancer: clinicopathological correlation. J Genet. 2016;95:551-63 pubmed
    ..comprising of almost equal proportion of four subtypes were tested for molecular alterations of SLIT2, ROBO1, ROBO2 and CDC42, the key regulator genes of this pathway...
  31. Lee M, Yoon J, Song H, Lee B, Lam D, Yoon J, et al. Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity. Dev Biol. 2017;424:62-76 pubmed publisher
    ..of Tcf7l2-deficient TCAs were associated at least in part with downregulation of guidance receptors Robo1 and Robo2 expression...
  32. Wainwright E, Wilhelm D, Combes A, Little M, Koopman P. ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation. Dev Biol. 2015;404:88-102 pubmed publisher
    b>ROBO2 plays a key role in regulating ureteric bud (UB) formation in the embryo, with mutations in humans and mice leading to supernumerary kidneys...
  33. Chang J, Lan T, Li C, Ji X, Zheng L, Gou H, et al. Activation of Slit2-Robo1 signaling promotes liver fibrosis. J Hepatol. 2015;63:1413-20 pubmed publisher
    ..Liver fibrosis was induced in wild-type (WT), Slit2 transgenic (Slit2-Tg) and Robo1(+/-)Robo2(+/-) double heterozygotes (Robo1/2(+/-)) mice by carbon tetrachloride (CCl4)...
  34. Ordan E, Volk T. Cleaved Slit directs embryonic muscles. Fly (Austin). 2015;9:82-5 pubmed publisher
    ..b>Robo2, which is co-expressed with Slit by the tendon cells facilitates Slit cleavage...
  35. Clegg J, Li Z, Molinek M, Caballero I, Manuel M, Price D. Pax6 is required intrinsically by thalamic progenitors for the normal molecular patterning of thalamic neurons but not the growth and guidance of their axons. Neural Dev. 2015;10:26 pubmed publisher
    ..We found that thalamic neurons show reduced expression of the Slit receptor Robo2 in Pax6 (-/-) mutants, which might enhance the ability of their axons to enter the hypothalamus...
  36. Fan X, Yang H, Kumar S, Tumelty K, Pisarek Horowitz A, Rasouly H, et al. SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion. JCI Insight. 2016;1:e86934 pubmed publisher
    The repulsive guidance cue SLIT2 and its receptor ROBO2 are required for kidney development and podocyte foot process structure, but the SLIT2/ROBO2 signaling mechanism regulating podocyte function is not known...
  37. Tumelty K, Higginson Scott N, Fan X, Bajaj P, Knowlton K, Shamashkin M, et al. Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways. J Biol Chem. 2018;293:3039-3055 pubmed publisher
    ..However, direct cross-talk between the ROBO2-SLIT2 and BMP-Gremlin signaling pathways has not been established...
  38. Bjorke B, Shoja Taheri F, Kim M, Robinson G, Fontelonga T, Kim K, et al. Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling. Neural Dev. 2016;11:18 pubmed
    ..high levels of both Slit1 and 2, and that oculomotor neurons express the repellent Slit receptors Robo1 and Robo2. Therefore, Slit signals are in a position to influence the migration of oculomotor neurons...
  39. Li X, Yu Q, Zhou Q, Zhao X, Liu Z, Cui W, et al. BmRobo2/3 is required for axon guidance in the silkworm Bombyx mori. Gene. 2016;577:174-9 pubmed publisher
    ..However, the function of Robo in the silkworm, Bombyx mori, remained unknown. In this study, we cloned robo2/3 from B. mori (Bmrobo2/3), a homologue of robo2/3 in Tribolium castaneum...
  40. Carr L, Parkinson D, Dun X. Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system. PLoS ONE. 2017;12:e0172736 pubmed publisher
    ..While Slit1 and Robo2 are only expressed in peripheral axons and their cell bodies, Slit2, Slit3 and Robo1 are also expressed in ..
  41. Qin N, Fan X, Zhang Y, Xu X, Tyasi T, Jing Y, et al. New insights into implication of the SLIT/ROBO pathway in the prehierarchical follicle development of hen ovary. Poult Sci. 2015;94:2235-46 pubmed publisher
    ..the spatial and temporal expression of the SLIT ligand genes (SLIT1, SLIT2, and SLIT3) and their receptor ROBO1, ROBO2, ROBO3, and ROBO4 genes in various-sized prehierarchical follicles during hen ovary development and the effects of ..
  42. Dominici C, Rappeneau Q, Zelina P, Fouquet S, Chédotal A. Non-cell autonomous control of precerebellar neuron migration by Slit and Robo proteins. Development. 2018;145: pubmed publisher
    ..It has previously been shown that Slit chemorepellents and their receptors, Robo1 and Robo2, might control the migration of precerebellar neurons in a repulsive manner...
  43. Gore B, Miller S, Jo Y, Baird M, Hoon M, Sanford C, et al. Roundabout receptor 2 maintains inhibitory control of the adult midbrain. elife. 2017;6: pubmed publisher
    ..Here we find that the developmental axon guidance receptor Roundabout 2 (Robo2) is critical for the maintenance of inhibitory synapses in the adult ventral tegmental area (VTA), a brain region ..
  44. Jin X, Shin Y, Riew T, Choi J, Lee M. Increased Expression of Slit2 and its Robo Receptors During Astroglial Scar Formation After Transient Focal Cerebral Ischemia in Rats. Neurochem Res. 2016;41:3373-3385 pubmed
    ..of this study was to investigate the temporal changes and cellular localization of Slit2 and its receptors, Robo1, Robo2, and Robo4, in a rat transient focal ischemia model induced by middle cerebral artery occlusion...
  45. Elahi S, Homstad A, Vaidya H, Stout J, Hall G, Wu G, et al. Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux. Pediatr Nephrol. 2016;31:247-53 pubmed publisher
    ..PVUR (NFPVUR) for rare missense variants inTNXB and the tenascin C gene (TNC) after excluding mutations in ROBO2 and SOX17...
  46. Swadi R, Mather G, Pizer B, Losty P, See V, Moss D. Optimising the chick chorioallantoic membrane xenograft model of neuroblastoma for drug delivery. BMC Cancer. 2018;18:28 pubmed publisher
    ..2) reduction in cell proliferation using Ki67 staining and 3) changes in differentiation markers (STMN4 and ROBO2) and stem cell marker (KLF4). Results were compared to MLN8237, a classical Aurora Kinase A inhibitor...
  47. Guerrero Cazares H, Lavell E, Chen L, Schiapparelli P, Lara Velazquez M, Capilla Gonzalez V, et al. Brief Report: Robo1 Regulates the Migration of Human Subventricular Zone Neural Progenitor Cells During Development. Stem Cells. 2017;35:1860-1865 pubmed publisher
    ..We describe that Robo1 and Robo2 isoforms are expressed in the human fetal SVZ...
  48. Jaafar C, Omais S, Al Lafi S, El Jamal N, Noubani M, Skaf L, et al. Role of Rb during Neurogenesis and Axonal Guidance in the Developing Olfactory System. Front Mol Neurosci. 2016;9:81 pubmed publisher
    ..This deficiency correlates with deregulated expressions of two key chemo-repellant molecules, Robo2/Slit1 and Nrp2/Sema3F that control the formation of dorsal-ventral topographic map of OSNs connections with OB ..
  49. Ordan E, Volk T. A non-signaling role of Robo2 in tendons is essential for Slit processing and muscle patterning. Development. 2015;142:3512-8 pubmed publisher
    ..Here, we show that the Slit receptor Roundabout 2 (Robo2) plays a non-cell-autonomous role in directing muscles to their corresponding tendons...
  50. Leong W, Lim Z, Korzh V, Pietri T, Goh E. Methyl-CpG Binding Protein 2 (Mecp2) Regulates Sensory Function Through Sema5b and Robo2. Front Cell Neurosci. 2015;9:481 pubmed publisher
    ..These defects were demonstrated to be dependent on the expression of Sema5b and Robo2. The expression of both proteins together could better overcome the defects caused by Mecp2 deficiency as compared ..
  51. Nguyen Ba Charvet K, Brose K, Marillat V, Kidd T, Goodman C, Tessier Lavigne M, et al. Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. Neuron. 1999;22:463-73 pubmed
    ..Here, we extend these findings into higher brain centers by showing that Robo1 and Robo2, as well as Slit1 and Slit2, are often expressed in complementary patterns in the developing forebrain...
  52. Marillat V, Cases O, Nguyen Ba Charvet K, Tessier Lavigne M, Sotelo C, Chedotal A. Spatiotemporal expression patterns of slit and robo genes in the rat brain. J Comp Neurol. 2002;442:130-55 pubmed
    ..Three distinct slit genes (slit1, slit2, and slit3) and three distinct robo genes (robo1, robo2, rig-1) have been cloned in mammals...
  53. Gu F, Ma Y, Zhang J, Qin F, Fu L. Function of Slit/Robo signaling in breast cancer. Front Med. 2015;9:431-6 pubmed publisher
    ..This review includes recent studies on the functions of Slit/Robo signaling in breast cancer and its molecular mechanisms. ..
  54. Cordell H, Darlay R, Charoen P, Stewart A, Gullett A, Lambert H, et al. Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux. J Am Soc Nephrol. 2010;21:113-23 pubmed publisher
    ..We tested for but did not detect association with six candidate genes (AGTR2, HNF1B, PAX2, RET, ROBO2, and UPK3A)...
  55. Chen C, Tsai C, Chen C, Wu Y, Chen C. Human placental multipotent mesenchymal stromal cells modulate placenta angiogenesis through Slit2-Robo signaling. Cell Adh Migr. 2016;10:66-76 pubmed publisher
    ..Human umbilical vein endothelial cells do not express Robo2 and Robo3...
  56. Vaughen J, Igaki T. Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia. Dev Cell. 2016;39:683-695 pubmed publisher
    ..Thus, how JNK executed cell elimination remained elusive. Here, we show that repulsive Slit-Robo2-Ena signaling exerts an extrusive force downstream of JNK to eliminate scrib cells from epithelia by disrupting E-..
  57. Sokolowski M, Wasserman J, Wasserman D. Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters. Mol Psychiatry. 2010;15:10-1 pubmed publisher
  58. Chang Z, Dong L, Qin Y, Song M, Guo H, Zhu Q. Correlations between gastric cancer family history and ROBO2 and RASSF2A gene methylations. J Cancer Res Ther. 2016;12:597-600 pubmed publisher
    To explore the correlation between ROBO2 and RASSF2A gene methylations and gastric cancer family history. ROBO2 and RASSF2A gene methylations in gastric cancer tissues and peri.cancerous tissues were detected with methylation...
  59. Sasse S, Klämbt C. Repulsive Epithelial Cues Direct Glial Migration along the Nerve. Dev Cell. 2016;39:696-707 pubmed publisher
    ..strikingly, we found that glial cells require the expression of the repulsive guidance receptors PlexinA/B and Robo2 to prevent breaking away from the nerve...
  60. Yom Tov G, Barak R, Matalon O, Barda Saad M, Guez Haddad J, Opatowsky Y. Robo Ig4 Is a Dimerization Domain. J Mol Biol. 2017;429:3606-3616 pubmed publisher
    ..We have determined the crystal structure of the tandem Ig4-5 domains (D4-5) of human Robo2 and found that a hydrophobic surface on D4 mediates close homotypic contacts with a reciprocal D4...
  61. Yue Y, Grossmann B, Galetzka D, Zechner U, Haaf T. Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice. Genomics. 2006;88:772-778 pubmed publisher
    ..Here we describe novel isoform a of human ROBO2, which is initially strongly expressed in the fetal human brain but thereafter only weakly expressed in adult ..
  62. Hivert B, Liu Z, Chuang C, Doherty P, Sundaresan V. Robo1 and Robo2 are homophilic binding molecules that promote axonal growth. Mol Cell Neurosci. 2002;21:534-45 pubmed
    In the present study we show that following transfection in 3T3 cells, human Robo1 and Robo2 stimulate neurite outgrowth from Robo-positive neurons (retinal neurons and olfactory neurons), but have no effect on Robo-negative neurons (..
  63. Shi C, Uda Y, Dedic C, Azab E, Sun N, Hussein A, et al. Carbonic anhydrase III protects osteocytes from oxidative stress. FASEB J. 2018;32:440-452 pubmed publisher
    ..Aspn, Enpp2, Robo2, Nov, and Serpina3g were among the transcripts that were most significantly suppressed in high-Sost cells...
  64. Hwang D, Kohl S, Fan X, Vivante A, Chan S, Dworschak G, et al. Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract. Hum Genet. 2015;134:905-16 pubmed publisher
    ..SRGAP1 is a small GTPase-activating protein in the SLIT2-ROBO2 signaling pathway, which is essential for development of the metanephric kidney...
  65. James G, Key B, Beverdam A. The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system. Brain Struct Funct. 2014;219:861-74 pubmed publisher
    ..These defects were similar to the olfactory bulb phenotype in loss-of-ROBO2 function mice...
  66. Prescott J, Thompson D, Kraft P, Chanock S, Audley T, Brown J, et al. Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women. PLoS ONE. 2012;7:e37815 pubmed publisher
    ..Our results suggest that the small magnitude of difference in hormone levels associated with common genetic variants is likely insufficient to detectably contribute to breast cancer risk. ..
  67. Bertoli Avella A, Conte M, Punzo F, de Graaf B, Lama G, La Manna A, et al. ROBO2 gene variants are associated with familial vesicoureteral reflux. J Am Soc Nephrol. 2008;19:825-31 pubmed publisher
    The SLIT2 receptor ROBO2 plays a key role in the formation of the ureteric bud, and its inactivation in mice leads to supernumerary ureteric bud development, lack of ureter remodeling, and improper insertion of the ureters into the ..
  68. Xu F, Wu L, Chang C, He Q, Zhang Z, Liu L, et al. Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes. Nat Commun. 2015;6:8806 pubmed publisher
    The progressive mechanism underlying myelodysplastic syndrome remains unknown. Here we identify ROBO1 and ROBO2 as novel progression-related somatic mutations using whole-exome and targeted sequencing in 6 of 16 (37...
  69. Viding E, Hanscombe K, Curtis C, Davis O, Meaburn E, Plomin R. In search of genes associated with risk for psychopathic tendencies in children: a two-stage genome-wide association study of pooled DNA. J Child Psychol Psychiatry. 2010;51:780-8 pubmed publisher
    ..These SNPs include neurodevelopmental genes such as ROBO2. Although none of the SNPs reached genome-wide statistical significance we have generated a list of SNPs that are ..
  70. Choi Y, Yoo N, Lee S. Down-regulation of ROBO2 expression in prostate cancers. Pathol Oncol Res. 2014;20:517-9 pubmed publisher
    ..Axon guidance genes ROBO1 and ROBO2 are candidate tumor suppressor genes (TSG)...
  71. Patel K, Nash J, Itoh A, Liu Z, Sundaresan V, Pini A. Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons. Development. 2001;128:5031-7 pubmed
  72. Potkin S, Turner J, Guffanti G, Lakatos A, Fallon J, Nguyen D, et al. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophr Bull. 2009;35:96-108 pubmed publisher
    ..SNPs) each significant at P < 10(-6) for the interaction between the imaging QT and the diagnosis (ROBO1-ROBO2, TNIK, and CTXN3-SLC12A2). Three other genes had a significant SNP at <10(-6) (POU3F2, TRAF, and GPC1)...
  73. O Sullivan M, Punal V, Kerstein P, Brzezinski J, Glaser T, Wright K, et al. Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development. Glia. 2017;65:1697-1716 pubmed publisher
    ..Analysis of Robo1; Robo2 mutants, in which RGC axon guidance is disrupted, and Math5 (Atoh7) mutants, which lack RGCs, reveals that RGCs ..
  74. Teh D, Prasad A, Jiang W, Ariffin M, Khanna S, Belorkar A, et al. Transcriptome Analysis Reveals Neuroprotective aspects of Human Reactive Astrocytes induced by Interleukin 1?. Sci Rep. 2017;7:13988 pubmed publisher
    ..In addition, most genes regulating axonal inhibitory molecules, including ROBO1 and ROBO2 were downregulated...
  75. St Pourcain B, Cents R, Whitehouse A, Haworth C, Davis O, O Reilly P, et al. Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nat Commun. 2014;5:4831 pubmed publisher
    ..For the early phase, one single-nucleotide polymorphism (rs7642482) at 3p12.3 near ROBO2, encoding a conserved axon-binding receptor, reaches the genome-wide significance level (P=1...
  76. Lu W, van Eerde A, Fan X, Quintero Rivera F, Kulkarni S, Ferguson H, et al. Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. Am J Hum Genet. 2007;80:616-32 pubmed
    ..This translocation disrupts ROBO2, which encodes a transmembrane receptor for SLIT ligand, and produces dominant-negative ROBO2 proteins that ..
  77. Dadds M, Moul C, Cauchi A, Hawes D, Brennan J. Replication of a ROBO2 polymorphism associated with conduct problems but not psychopathic tendencies in children. Psychiatr Genet. 2013;23:251-4 pubmed publisher
    ..We replicated the finding that a polymorphism associated with the ROBO2 gene, which is involved in neurodevelopment, confers risk for the common emotionally reactive, impulsive aspects ..
  78. Je E, Gwak M, Oh H, Choi M, Choi Y, Lee S, et al. Frameshift mutations of axon guidance genes ROBO1 and ROBO2 in gastric and colorectal cancers with microsatellite instability. Pathology. 2013;45:645-50 pubmed publisher
    ..ROBO1 and ROBO2, crucial regulators of axon guidance, are considered potential tumour suppressor genes...
  79. Zu S, Bartik Z, Zhao S, Sillen U, Nordenskjold A. Mutations in the ROBO2 and SLIT2 genes are rare causes of familial vesico-ureteral reflux. Pediatr Nephrol. 2009;24:1501-8 pubmed publisher
    ..The SLIT2 protein and its receptor, ROBO2, have key functions in the formation of the ureteric bud...
  80. Kim M, Fontelonga T, Lee C, Barnum S, Mastick G. Motor axons are guided to exit points in the spinal cord by Slit and Netrin signals. Dev Biol. 2017;432:178-191 pubmed publisher
    ..secreted Slit proteins are major floor plate repellents, and motor neurons express two Slit receptors, Robo1 and Robo2. Using mutant mouse embryos at early stages of motor axon exit, we found that motor exit points shifted ventrally ..
  81. Grieshammer U, Le Ma -, Plump A, Wang F, Tessier Lavigne M, Martin G. SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell. 2004;6:709-17 pubmed
    ..Here we show that mouse mutants lacking either SLIT2 or its receptor ROBO2, molecules known primarily for their function in axon guidance and cell migration, develop supernumerary ureteric ..
  82. Dickinson R, Myers M, Duncan W. Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women. Endocrinology. 2008;149:5024-34 pubmed publisher
    ..In vertebrates three Slit (Slit1, Slit2, Slit3) and four Robo (Robo1, Robo2, Robo3/Rig-1, Robo4/Magic Robo) genes have been identified...
  83. Dobson M, Darlow J, Hunziker M, Green A, Barton D, Puri P. Heterozygous non-synonymous ROBO2 variants are unlikely to be sufficient to cause familial vesicoureteric reflux. Kidney Int. 2013;84:327-37 pubmed publisher
    b>ROBO2, the receptor of SLIT2, is one of many genes/proteins that regulate the outgrowth of the ureteric bud, which is the first step in the development of the metanephric urinary system...
  84. Mitsioni A, Siomou E, Bouba I, Petridi S, Siamopoulou A, Georgiou I. ROBO2 gene variants in children with primary nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia. Pediatr Res. 2016;80:72-6 pubmed publisher
    ..Sequence variations of the ROBO2 gene were investigated in children with nonsyndromic VUR or VUR-RHD...
  85. Brose K, Bland K, Wang K, Arnott D, Henzel W, Goodman C, et al. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell. 1999;96:795-806 pubmed
    ..These results support the hypothesis that Slit proteins have an evolutionarily conserved role in axon guidance as repulsive ligands for Robo receptors. ..
  86. Liu J, Sun L, Shen Q, Wu X, Xu H. New congenital anomalies of the kidney and urinary tract and outcomes in Robo2 mutant mice with the inserted piggyBac transposon. BMC Nephrol. 2016;17:98 pubmed publisher
    Disruption of ROBO2 in humans causes vesicoureteral reflux (VUR)/congenital anomalies of the kidney and urinary tract (CAKUT). PiggyBac (PB) is a DNA transposon, and its insertion often reduces-but does not eliminate-gene expression...