RNPC3

Summary

Gene Symbol: RNPC3
Description: RNA-binding region (RNP1, RRM) containing 3
Alias: RBM40, RNP, RNA recognition protein, RNA-binding motif protein 40, RNA-binding protein 40, RNA-binding region-containing protein 3, U11/U12 small nuclear ribonucleoprotein 65 kDa protein, U11/U12 snRNP 65 kDa protein, U11/U12 snRNP 65K, U11/U12-65K
Species: human

Top Publications

  1. ncbi Should Graves' disease be considered a collagen disorder of the thyroid, skeletal muscle and connective tissue?
    J Kiljanski
    The Thyroid Eye Disease Research Laboratory, Allegheny Singer, Research Institute, Pittsburgh, USA
    Horm Metab Res 27:528-32. 1995
  2. ncbi Neonatal lupus erythematosus in an infant with Turner syndrome
    E Ruas
    Dermatology Clinic, Hospitais da Universidade de Coimbra, Portugal
    Pediatr Dermatol 13:298-302. 1996
  3. ncbi Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure
    W Forrester
    Department of Biochemistry, College of Agricultural and Life Sciences, Madison, Wisconsin 53706
    Genes Dev 6:1914-26. 1992
  4. ncbi Ultrastructural, cytochemical, and immunocytochemical study of nuclei and cytoskeleton of thyroid papillary carcinoma cells
    O M Echeverria
    Laboratory of Electron Microscopy, Faculty of Sciences, D F, Mexico
    Ultrastruct Pathol 22:185-97. 1998
  5. ncbi Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens
    Chao Jiang
    Division of Rheumatology and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 184:1085-91. 2010
  6. ncbi Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer
    Ahmed Al-Shukaili
    Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Muscat, Sultanate of Oman
    Saudi Med J 27:1873-7. 2006
  7. ncbi Molecular biological ontogenesis of the thymic reticulo-epithelial cell network during the organization of the cellular microenvironment
    B Bodey
    Department of Pathology, University of Southern California, Los Angeles, USA
    In Vivo 13:267-94. 1999
  8. ncbi [How can we diagnose and better understand inflammatory myopathies? The usefulness of auto-antibodies]
    Jean Sibilia
    CHU de Strasbourg, Hopital Hautepierre, Service de Rhumatologie, Laboratoire d Immunologie, 67098 Strasbourg Cedex, France
    Presse Med 39:1010-25. 2010
  9. ncbi Neonatal lupus erythematosus related to maternal leukocytoclastic vasculitis
    L Borrego
    Department of Dermatology, Hospital Insular, Las Palmas de Gran Canaria, Canary Islands, Spain
    Pediatr Dermatol 14:221-5. 1997
  10. ncbi Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation
    Donald D Raymond
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:11769-74. 2010

Research Grants

  1. Structure and Function in Catalytic RNP Assembly
    Mark Foster; Fiscal Year: 2009
  2. Immune Response to Small Nuclear Ribonucleoprotein Autoantigens
    Robert Hoffman; Fiscal Year: 2007
  3. The influenza A virus nucleoprotein: structure and function
    Yizhi Tao; Fiscal Year: 2009
  4. The influenza A virus nucleoprotein: structure and function
    YIZHI JANE contact TAO; Fiscal Year: 2010
  5. SPLICING OF MRNA PRECURSORS
    Michael R Green; Fiscal Year: 2010
  6. Small RNP Mediators of Gene Expression
    JOAN STEITZ; Fiscal Year: 2009
  7. Small RNP Mediators of Gene Expression
    Joan A Steitz; Fiscal Year: 2010
  8. Small RNP Mediators of Gene Expression
    JOAN STEITZ; Fiscal Year: 2007
  9. Structure and dynamics of the Tetrahymena telomerase ribonucleoprotein
    Michael D Stone; Fiscal Year: 2011
  10. Spinal muscular atrophy: a novel role of SMN in axonal ribonucleoprotein complexe
    Wilfried Rossoll; Fiscal Year: 2007

Detail Information

Publications144 found, 100 shown here

  1. ncbi Should Graves' disease be considered a collagen disorder of the thyroid, skeletal muscle and connective tissue?
    J Kiljanski
    The Thyroid Eye Disease Research Laboratory, Allegheny Singer, Research Institute, Pittsburgh, USA
    Horm Metab Res 27:528-32. 1995
    ..a fine speckled fluorescence, found in 45% of sera, consistent with reactivity against the Sm antigen or nuclear RNP. The finding of a high prevalence of ANA and, less often, anti-connective tissue antibodies in patients with ..
  2. ncbi Neonatal lupus erythematosus in an infant with Turner syndrome
    E Ruas
    Dermatology Clinic, Hospitais da Universidade de Coimbra, Portugal
    Pediatr Dermatol 13:298-302. 1996
    ..examinations revealed the presence of anti-Ro(SSA) and anti-La(SSB) antibodies, and absence of anti-Sm and anti-RNP antibodies. Karyotyping revealed Turner syndrome (TS) with 45,XO sex chromosome constitution...
  3. ncbi Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure
    W Forrester
    Department of Biochemistry, College of Agricultural and Life Sciences, Madison, Wisconsin 53706
    Genes Dev 6:1914-26. 1992
    ..We speculate that the perturbations in mRNA processing are the result of effects on the chromatin-nascent RNP-transcription complex or misregulation of a cell cycle component that modifies multiple mRNA-processing activities.
  4. ncbi Ultrastructural, cytochemical, and immunocytochemical study of nuclei and cytoskeleton of thyroid papillary carcinoma cells
    O M Echeverria
    Laboratory of Electron Microscopy, Faculty of Sciences, D F, Mexico
    Ultrastruct Pathol 22:185-97. 1998
    ..Some nucleoli were surrounded by a double fibrillar layer limiting a perinucleolar space occupied by RNP fibrogranular structures that differed from those of normal nuclei...
  5. ncbi Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens
    Chao Jiang
    Division of Rheumatology and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 184:1085-91. 2010
    ..Only sera from DR3 and DQ0604 mice immunoprecipitated A-ribonucleoprotein (RNP), SmB, and SmD...
  6. ncbi Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer
    Ahmed Al-Shukaili
    Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Muscat, Sultanate of Oman
    Saudi Med J 27:1873-7. 2006
    ..To investigate the prevalence of a group of different autoantibodies, in Omani patients with gastric cancer, and to examine whether their presence correlates with clinical course of the disease...
  7. ncbi Molecular biological ontogenesis of the thymic reticulo-epithelial cell network during the organization of the cellular microenvironment
    B Bodey
    Department of Pathology, University of Southern California, Los Angeles, USA
    In Vivo 13:267-94. 1999
    ..Their cytoplasm occasionally displays RNP granules, and is rich in non-histone proteins, fine phospholipid, lipid or cholesterin granules, and vacuoles ..
  8. ncbi [How can we diagnose and better understand inflammatory myopathies? The usefulness of auto-antibodies]
    Jean Sibilia
    CHU de Strasbourg, Hopital Hautepierre, Service de Rhumatologie, Laboratoire d Immunologie, 67098 Strasbourg Cedex, France
    Presse Med 39:1010-25. 2010
    ..These auto-antibodies are directed against nuclear or nucleolar auto-antigens: the anti-PM-Scl, anti-Ku, anti-RNP (U1 RNP and U2 RNP, U4/U6 RNP and U5 RNP), anti-Ro 52 kDa and more rarely, anti-Ro 60 kDa and anti-La...
  9. ncbi Neonatal lupus erythematosus related to maternal leukocytoclastic vasculitis
    L Borrego
    Department of Dermatology, Hospital Insular, Las Palmas de Gran Canaria, Canary Islands, Spain
    Pediatr Dermatol 14:221-5. 1997
    ..Affected infants have maternal, transplacentally acquired, autoantibodies to Ro/SSA, La/SSB, or U1-RNP antigens. Anti-Ro/SSA is the predominant autoantibody, present in about 95% of cases...
  10. ncbi Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation
    Donald D Raymond
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:11769-74. 2010
    ..The 1.93-A crystal structure of RVFV N and electron micrographs of ribonucleoprotein (RNP) reveal an encapsidated genome of substantially different organization than in other negative-sense RNA virus ..
  11. ncbi Investigating the specificity and stoichiometry of RNA binding by the nucleocapsid protein of Bunyamwera virus
    Bjorn Patrick Mohl
    Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS29JT, West Yorkshire, United Kingdom
    RNA 15:391-9. 2009
    ..along their entire lengths with the virus-encoded nucleocapsid (N) protein to form a ribonucleoprotein (RNP) complex...
  12. ncbi Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein
    M J Matunis
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia 19104 6148
    Mol Cell Biol 12:164-71. 1992
    At least 20 major proteins make up the ribonucleoprotein (RNP) complexes of heterogeneous nuclear RNA (hnRNA) in mammalian cells. Many of these proteins have distinct RNA-binding specificities...
  13. ncbi Crystal structure of protein Ph1481p in complex with protein Ph1877p of archaeal RNase P from Pyrococcus horikoshii OT3: implication of dimer formation of the holoenzyme
    Shin Kawano
    Laboratory of Biochemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812 8581, Japan
    J Mol Biol 357:583-91. 2006
    ..beta-sheet and five helices, which fold in a way that is topologically similar to the ribonucleoprotein (RNP) domain...
  14. ncbi Evolution of influenza A virus PB2 genes: implications for evolution of the ribonucleoprotein complex and origin of human influenza A virus
    O T Gorman
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38101 0318
    J Virol 64:4893-902. 1990
    ..The completion of evolutionary analyses of the PB1, PB2, PA and NP genes of the ribonucleoprotein (RNP) complex permits comparison of evolutionary pathways...
  15. ncbi [Low prevalence of anti-centromere antibodies in scleroderma in Morocco (about 272 cases)]
    B Admou
    Faculte de Medecine, Marrakech, Morocco
    Ann Biol Clin (Paris) 65:291-7. 2007
    ..assessment of autoantibodies prevalence during scleroderma within a Moroccan population by a retrospective survey...
  16. ncbi Neonatal lupus erythematosus: an unusual congenital presentation with cutaneous atrophy, erosions, alopecia, and pancytopenia
    E Crowley
    University of Illinois, College of Medicine, Urbana, USA
    Pediatr Dermatol 15:38-42. 1998
    ..Ro, La, and RNP antibodies were absent, and the diagnosis was made because of light microscopic and immunofluorescent findings...
  17. ncbi Clinical and serologic correlations and autoantibody clusters in systemic lupus erythematosus: a retrospective review of 917 patients in South China
    Xuhua Tang
    Department of Dermatology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    Medicine (Baltimore) 89:62-7. 2010
    ..with higher prevalence of malar rash/discoid rash, pericarditis, and leukopenia; anti-ribonucleoprotein (anti-RNP) with higher prevalence of Raynaud phenomenon and photosensitivity; anti-deoxyribonucleoprotein (anti-DNP) with ..
  18. ncbi Age-correlated changes in the lupus erythematosus antigens Ro, La, Sm and RNP of the thymus gland
    W E Muller
    Institut fur Physiologische Chemie, Universitat, Mainz, West Germany
    Compr Gerontol A 1:40-4. 1987
    The concentrations of the Sm, RNP, La and Ro antigens of thymus glands from rats were determined depending on the developmental stage of the animals. It was found that lupus antigens strongly decrease after birth...
  19. ncbi Development of recombinant nucleoprotein-based diagnostic systems for Lassa fever
    Masayuki Saijo
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama, Tokyo 208 0011, Japan
    Clin Vaccine Immunol 14:1182-9. 2007
    ..for the detection of LASV antibodies and LASV antigens, were developed using the recombinant nucleoprotein (rNP) of LASV (LASV-rNP). The LASV-rNP was expressed in a recombinant baculovirus system...
  20. ncbi Atypical autoantibodies in patients with primary Sjögren syndrome: clinical characteristics and follow-up of 82 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain
    Semin Arthritis Rheum 35:312-21. 2006
    ..To analyze the clinical characteristics, follow-up, and fulfillment of classification criteria for other systemic autoimmune diseases (SAD) in patients with primary Sjögren syndrome (SS) and atypical autoantibodies...
  21. ncbi The association of antinuclear antibodies with organ involvement and survival in systemic sclerosis
    R Hesselstrand
    Department of Rheumatology, Lund University Hospital, Lund, Sweden
    Rheumatology (Oxford) 42:534-40. 2003
    ..To study the frequency and specificity of antinuclear antibodies (ANA) and their association with internal organ involvement and survival in systemic sclerosis (SSc)...
  22. ncbi Anti-extractable nuclear antigens (ENA) antibodies in patients with chronic hepatitis C before and after treatment with interferon
    Katsuhisa Omagari
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Autoimmunity 36:269-73. 2003
    ..hepatitis C and 44 patients with non-hepatitis C virus (HCV) infected liver diseases were tested for anti-ENAs (U1 RNP, Sm, Ro/SS-A, La/SS-B and Scl-70) antibodies by enzyme-linked immunosorbent assay (ELISA)...
  23. ncbi [Resistance to the action of atrial natriuretic peptide and urodilatin in Heymann nephritis in vitro]
    J P Valentin
    Department of Medicine, San Francisco General Hospital, CA, USA
    Arch Mal Coeur Vaiss 87:1125-9. 1994
    ..glomeruli and inner medullary collecting duct (IMCD) cells in response to increasing concentration of ANP, and RNP (also called urodilatin). Results (fmol/mg prot/10 min) are means +/- SEM: [table: see text]...
  24. ncbi Infectious Bursal disease virus: ribonucleoprotein complexes of a double-stranded RNA virus
    Daniel Luque
    Department of Structure of Macromolecules, Centro Nacional de Biotecnologia CSIC, C Darwin No 3, Cantoblanco, E 28049 Madrid, Spain
    J Mol Biol 386:891-901. 2009
    ..dsRNA viruses nevertheless lack these ribonucleoprotein (RNP) complexes and are characterized by sharing an icosahedral T=2 core involved in the metabolism and insulation of ..
  25. ncbi High level expression of recombinant mumps nucleoprotein in Saccharomyces cerevisiae and its evaluation in mumps IgM serology
    Dhanraj Samuel
    Enteric, Respiratory and Neurological Virus Laboratory, Central Public Health Laboratory, London, United Kingdom
    J Med Virol 66:123-30. 2002
    ..for mumps serology a high-level yeast expression system was employed to produce recombinant mumps nucleoprotein (rNP). The rNP was purified by CsCl gradient centrifugation and yielded approximately 15 mg/l of yeast culture...
  26. ncbi A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen
    Eric L Greidinger
    Division of Rheumatology and Immunology, University of Miami, Miami, Florida 33136, USA
    Arthritis Rheum 54:661-9. 2006
    ..To test whether immunizing mice with autoantigens closely linked to mixed connective tissue disease (MCTD) could induce an MCTD-like clinical syndrome distinguishable from systemic lupus erythematosus (SLE)...
  27. ncbi Is antibody clustering predictive of clinical subsets and damage in systemic lupus erythematosus?
    C H To
    division of Rhumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 52:4003-10. 2005
    ..To examine autoantibody clusters and their associations with clinical features and organ damage accrual in patients with systemic lupus erythematosus (SLE)...
  28. ncbi Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex
    M Kiledjian
    Department of Cell, Developmental and Neurobiology, Rutgers University, Piscataway, New Jersey 08855, USA
    Mol Cell Biol 17:4870-6. 1997
    ..is an important regulatory component of gene expression and is significantly influenced by ribonucleoprotein (RNP) complexes which form on the mRNA...
  29. ncbi Determination of ANA specificity using multiplexed fluorescent microsphere immunoassay in patients with ANA positivity at high titres after infliximab treatment: preliminary results
    Paola Caramaschi
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Verona, Verona, Italy
    Rheumatol Int 27:649-54. 2007
    ..One patient affected by rheumatoid arthritis showed multiple ANA reactivities against SS-A, SS-B, RNP, Sm, Jo-1 and histones; one patient affected by ankylosing spondylitis resulted positive for the same ..
  30. ncbi Childhood-onset systemic lupus erythematosus: a comparative study of African Americans and Latin Americans
    A Gedalia
    Department of Pediatrics, LSU Medical Center, New Orleans 70112 2822, USA
    J Natl Med Assoc 91:497-501. 1999
    ..In addition, there was a higher frequency of anti-dsDNA, anti-Sm, anti-RNP, and anti-Ro positivity among African-Americans compared with Latin-American patients...
  31. ncbi Specific humoral reaction of hemorrhagic fever with renal syndrome (HFRS) patients in China to recombinant nucleocapsid proteins from European hantaviruses
    H R Xiong
    State Key Laboratory of Virology Institute of Medical Virology, School of Medicine, Wuhan University, 185 DongHu Road, Wuhan 430071, PR China
    Eur J Clin Microbiol Infect Dis 30:645-51. 2011
    ..The results showed that the sensitivity of rNPs against IgG was HTNV-rNP > DOBV-rNP > PUUV-rNP, while the sensitivity against IgA was DOBV-rNP > HTNV-rNP > PUUV-rNP...
  32. ncbi Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine:histone-arginine N-methyltransferase
    R Rajpurohit
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140
    J Biol Chem 269:1075-82. 1994
    ....
  33. ncbi Structural requirements for transport of preprocecropinA and related presecretory proteins into mammalian microsomes
    G Schlenstedt
    Zentrum Biochemie/Abt. Biochemie II, , Germany
    J Biol Chem 267:24328-32. 1992
    ..We investigated the role of the precursor structure with respect to competence for RNP-independent transport by constructing deletion mutants and hybrid proteins...
  34. ncbi C-reactive protein reacts with the U1 small nuclear ribonucleoprotein
    T W Du Clos
    Department of Medicine, VA Medical Center, Albuquerque, New Mexico 87108
    J Immunol 143:2553-9. 1989
    ..Double staining with anti-RNP serum and CRP produced very similar staining patterns...
  35. ncbi Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features
    Shyamasri Biswas
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States
    Biochemistry 50:2907-18. 2011
    Box C/D ribonucleoproteins (RNP) guide the 2'-O-methylation of targeted nucleotides in archaeal and eukaryotic rRNAs. The archaeal L7Ae and eukaryotic 15...
  36. ncbi An umbraviral protein, involved in long-distance RNA movement, binds viral RNA and forms unique, protective ribonucleoprotein complexes
    Michael Taliansky
    Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, United Kingdom
    J Virol 77:3031-40. 2003
    ..of the TMV CP [TMV(ORF3)], in infected cells it interacted with the TMV RNA to form filamentous ribonucleoprotein (RNP) particles that had elements of helical structure but were not as uniform as classical virions...
  37. ncbi Immune responses to small nuclear ribonucleoproteins: antigen-dependent distinct B cell epitope spreading patterns in mice immunized with recombinant polypeptides of small nuclear ribonucleoproteins
    Umesh S Deshmukh
    Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 168:5326-32. 2002
    ..Ab responses, we immunized A/J mice with recombinant Smith D (SmD), Smith B (SmB), and A ribonucleoprotein (A-RNP) with alum as adjuvant...
  38. ncbi Mapping RNA-protein interactions in ribonuclease P from Escherichia coli using electron paramagnetic resonance spectroscopy
    V Gopalan
    Department of Biology, Yale University, New Haven, Connecticut 06520, USA
    Biochemistry 38:1705-14. 1999
    Ribonuclease P (RNase P) is a catalytic ribonucleoprotein (RNP) essential for tRNA biosynthesis. In Escherichia coli, this RNP complex is composed of a catalytic RNA subunit, M1 RNA, and a protein cofactor, C5 protein...
  39. ncbi Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo
    B Dichtl
    EMBL, Gene Expression Programme, Heidelberg, Germany
    EMBO J 16:417-29. 1997
    RNase MRP is a ribonucleoprotein (RNP) particle which is involved in the processing of pre-rRNA at site A3 in internal transcribed spacer 1...
  40. ncbi pH-sensitive radical-containing-nanoparticle (RNP) for the L-band-EPR imaging of low pH circumstances
    Toru Yoshitomi
    Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, 305 8573, Ibaraki, Japan
    Bioconjug Chem 20:1792-8. 2009
    For the imaging of low pH circumstances in vivo, a pH-sensitive radical-containing-nanoparticle (RNP), which has an intense electron paramagnetic resonance (EPR) signal, was designed and developed using a self-assembling amphiphilic ..
  41. ncbi Maternal mixed connective tissue disease and offspring with chondrodysplasia punctata
    Steffan W Schulz
    Division of Rheumatology, Thomas Jefferson University Hospital, Philadelphia, PA, USA
    Semin Arthritis Rheum 39:410-6. 2010
    ....
  42. ncbi Projection from the cerebellar lateral nucleus to precerebellar nuclei in the mossy fiber pathway is glutamatergic: a study combining anterograde tracing with immunogold labeling in the rat
    C Schwarz
    Sektion fur Visuelle Sensomotorik, Neurologische Universitätsklinik Tübingen, Germany
    J Comp Neurol 381:320-34. 1997
    ..that of cerebellonuclear terminals in two other target structures, the parvocellular part of the nucleus ruber (RNp) and the ventromedial and ventrolateral thalamus (VM/VL)...
  43. ncbi Evidence for different contributions of archaea and bacteria to the ammonia-oxidizing potential of diverse Oregon soils
    Anne E Taylor
    Department of Crop and Soil Science, 3017 ALS, Oregon State University, Corvallis, OR 97331, USA
    Appl Environ Microbiol 76:7691-8. 2010
    ..inactivate ammonia monooxygenase, and upon the removal of acetylene, the recovery of nitrification potential (RNP) was monitored in the presence and absence of bacterial or eukaryotic protein synthesis inhibitors...
  44. ncbi Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity
    Benjamin R tenOever
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    J Virol 78:10636-49. 2004
    ..VSV is required to induce activation of the IKK-related kinases and provide evidence that ribonucleoprotein (RNP) complex of VSV generated intracellularly during virus replication can activate TBK1 and IKKepsilon activity...
  45. ncbi Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons
    Honglai Zhang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 26:8622-32. 2006
    ..In immortalized non-neuronal cell lines, SMN has been shown to form a ribonucleoprotein (RNP) complex with Gemin proteins, which is essential for the assembly of small nuclear RNPs (snRNPs)...
  46. ncbi Influence of clinical features, serum antinuclear antibodies, and lung function on survival of patients with systemic sclerosis
    S Jacobsen
    Department of Rheumatology, Hvidovre Hospital, Denmark
    J Rheumatol 28:2454-9. 2001
    ..To evaluate the independent contribution of several clinical and laboratory variables to the mortality of a cohort of Danish patients with systemic sclerosis (SSc)...
  47. ncbi RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts
    Jack D Keene
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Protoc 1:302-7. 2006
    ..which mRNAs associate, nor can they be used to elucidate the dynamic composition of RNAs in ribonucleoprotein (RNP) complexes in response to physiological stimuli...
  48. ncbi Development of the human parvocellular red nucleus. A morphological study
    Katsuyuki Yamaguchi
    Department of Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    Dev Neurosci 30:325-30. 2008
    Morphology of the human parvocellular red nucleus (RNp) was investigated in 14 fetuses aged from 12 to 39 weeks of gestation (WG). The brains were processed into celloidin-embedded serial sections...
  49. ncbi The autoregulatory translational control element of poly(A)-binding protein mRNA forms a heteromeric ribonucleoprotein complex
    Gopal P Patel
    Department of Molecular and Cellular Biology, University of Guelph Guelph, Ontario, Canada, N1G 2W1
    Nucleic Acids Res 33:7074-89. 2005
    ..Using a modified ribonucleoprotein (RNP) immunoprecipitation procedure we further show that indeed, both IMP1 and UNR bind to the ARS containing reporter ..
  50. ncbi A polypyrimidine tract binding protein, pumpkin RBP50, forms the basis of a phloem-mobile ribonucleoprotein complex
    Byung Kook Ham
    Department of Plant Biology, College of Biological Sciences, University of California, Davis, California 95616, USA
    Plant Cell 21:197-215. 2009
    RNA binding proteins (RBPs) are integral components of ribonucleoprotein (RNP) complexes and play a central role in RNA processing. In plants, some RBPs function in a non-cell-autonomous manner...
  51. ncbi [Study on the recombinant expression of Hantaan virus protein N and the establishment and application of rNP-IgM direct capture ELISA]
    Han ping Zhu
    Department of Medical Microbiology and Parasitology, College of Medicine, Zhejiang University, Hangzhou 310058, China
    Zhonghua Liu Xing Bing Xue Za Zhi 28:692-6. 2007
    ..NP) of hantavirus strain Z10 (HV-Z10), to construct its prokaryotic expression system as well as to establish a rNP-IgM direct capture ELISA based on HRP-labeled recombinant NP (rNP), in order to detect serum samples of patients ..
  52. ncbi Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction
    K B Elkon
    Hospital for Special Surgery, Cornell Medical Center, New York, NY 10021
    J Immunol 145:636-43. 1990
    SmB and SmB' are the major antigenic proteins contained within small nuclear RNP particles that are recognized by both human SLE and MRL mouse anti-Sm sera...
  53. ncbi Determination of protein-RNA interaction sites in the Cbf5-H/ACA guide RNA complex by mass spectrometric protein footprinting
    Daniel L Baker
    Department of Biochemistry and Molecular Biology, and Genetics, University of Georgia, Athens, Georgia 30602, USA
    Biochemistry 47:1500-10. 2008
    ..In eukaryotes and archaea, these modifications are carried out by H/ACA ribonucleoprotein (RNP) complexes, composed of an H/ACA guide RNA and four proteins, including the pseudouridine synthase, Cbf5...
  54. ncbi HLA class II phenotype controls diversification of the autoantibody response in primary Sjögren's syndrome (pSS)
    M Rischmueller
    Department of Immunology, Allergy and Arthritis, Flinders Medical Centre and Flinders University of South Australia
    Clin Exp Immunol 111:365-71. 1998
    ..explained by intermolecular spreading of autoimmunity toward different components of the La/Ro ribonucleoprotein (RNP)...
  55. ncbi Incorporation of argyrophilic proteins into the nucleolus-associated chromatin caused by exposure to actinomycin D
    S Sato
    Department of Biology, Faculty of Science, Ehime University, Japan
    Biol Cell 63:19-26. 1988
    ..is formed, detailed observations were carried out on thin sections following silver staining and ribonucleoprotein (RNP) preferential staining...
  56. ncbi In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen
    Kindra M Kelly Scumpia
    University of Florida College of Medicine, Gainesville, FL 32610 0221, USA
    Arthritis Rheum 56:3379-86. 2007
    ..This study was undertaken to examine whether U1 RNA possesses adjuvant activity in vivo...
  57. ncbi Evaluation of the BioPlex 2200 ANA screen for the detection of antinuclear antibodies and comparison with conventional methods
    Sophie Desplat-Jego
    Laboratoire d Immunologie, Hopital de la Conception, Marseille, France
    Ann N Y Acad Sci 1109:245-55. 2007
    ..detection of antibodies against the following antigens: dsDNA, chromatin, SSA-52 kDa, SSA-60 kDa, SSB, Sm, Sm/RNP, RNP-A, RNP-68 kDa, Scl70, centromere B, Jo-1, and P ribosomal proteins...
  58. ncbi Human G3BP1 interacts with beta-F1-ATPase mRNA and inhibits its translation
    Alvaro D Ortega
    Departamento de Biologia Molecular, Centro de Biología Molecular Severo Ochoa CBMSO, CSIC UAM, Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, ISCIII, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Cell Sci 123:2685-96. 2010
    ..the mitochondrial H(+)-ATP synthase subunit beta (ATP5B, beta-F1-ATPase) is localized in a large ribonucleoprotein (RNP) complex (beta-F1-RNP), which is subjected to stringent translational control during development and the cell cycle,..
  59. ncbi Isolation and characterization of a complementary DNA expressing human U1 small nuclear ribonucleoprotein C polypeptide
    K Yamamoto
    Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan
    J Immunol 140:311-7. 1988
    ..vector lambda gt11 after screening with a patient's serum containing a high titer of anti-ribonucleoprotein (RNP) antibodies...
  60. ncbi [Extrachromosomal structures containing small nuclear RNP and coilin in the late vitellogenic oocytes of hibernating grass frogs]
    A G Tsvetkov
    Institute of Cytology RAS, St Petersburg
    Tsitologiia 44:1037-45. 2002
    ..were also positively stained with antibodies against Sm-epitope and trimetylguanosine cap of small nuclear (sn) RNP. According to the results of in situ nucleic acid hybridization, the nucleoli contain U6 snRNA...
  61. ncbi Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein
    J Hepojoki
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    J Gen Virol 91:2341-50. 2010
    Here we characterize the interaction between the glycoproteins (Gn and Gc) and the ribonucleoprotein (RNP) of Puumala virus (PUUV; genus Hantavirus, family Bunyaviridae)...
  62. ncbi Multiple plant RNA binding proteins identified by PCR: expression of cDNAs encoding RNA binding proteins targeted to chloroplasts in Nicotiana plumbaginifolia
    M Mieszczak
    Friedrich Miescher Institut, Basel, Switzerland
    Mol Gen Genet 234:390-400. 1992
    ..90 amino acids with a characteristic ribonucleoprotein consensus sequence (RNP-CS). A PCR approach that is suitable for the characterization of RNP-CS-type proteins is described...
  63. ncbi Autoantibodies in systemic sclerosis
    Virginia D Steen
    Department of Medicine, Georgetown University, Washington, DC 2007, USA
    Semin Arthritis Rheum 35:35-42. 2005
    ..To describe the clinical, laboratory, and prognostic features associated with the scleroderma-specific autoantibodies...
  64. ncbi Seawi--a sea urchin piwi/argonaute family member is a component of MT-RNP complexes
    Alexis J Rodriguez
    Department of Biological Sciences, Rutgers University, 101 Warren Street, 135 Smith Hall, Newark, NJ 07102, USA
    RNA 11:646-56. 2005
    ..Seawi is a major component of microtubule-ribonucleoprotein (MT-RNP) complexes isolated from two different species of sea urchin, Strongylocentrotus purpuratus and Paracentrotus ..
  65. ncbi The role of defensins in the excitability of the peripheral vestibular system in the frog: evidence for the presence of communication between the immune and nervous systems
    G N Andrianov
    Laboratory of Physiology of Reception, Pavlov Institute of Physiology, Russian Academy of Sciences, nab Makarova 6, St Petersburg 199034, Russia
    Hear Res 230:1-8. 2007
    ..study investigated the electrophysiological effects of externally applied human and rabbit defensins (HNP-1 and RNP-1, correspondingly) on afferent neurotransmission in the frog semicircular canals (SCC)...
  66. ncbi GLD-2/RNP-8 cytoplasmic poly(A) polymerase is a broad-spectrum regulator of the oogenesis program
    Kyung Won Kim
    Department of Biochemistry and Howard Hughes Medical Institute, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 107:17445-50. 2010
    ..One GLD-2 partner, RNP-8, was previously shown to influence oocyte fate specification...
  67. ncbi Endothelial cell-binding activity of anti-U1-ribonucleoprotein antibodies in patients with connective tissue diseases
    M Okawa-Takatsuji
    Division of Clinical Immunology, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Clin Exp Immunol 126:345-54. 2001
    In order to elucidate the immunological properties of anti-U1-ribonucleoprotein (RNP) antibody, one of the autoantibodies detected in patients with connective tissue diseases (CTDs), we tested the endothelial cell-binding by anti-U1-RNP ..
  68. ncbi Differential localization of the two T. brucei poly(A) binding proteins to the nucleus and RNP granules suggests binding to distinct mRNA pools
    Susanne Kramer
    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 8:e54004. 2013
    ..Most striking are differences in localization to the four known types of inducible RNP granules. Moreover, only PABP2 but not PABP1 can accumulate in the nucleus...
  69. ncbi Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle
    Song Xue
    Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
    Mol Cell 39:939-49. 2010
    ..Here we report crystal structures of an archaeal box C/D RNP containing three core proteins (fibrillarin, Nop56/58, and L7Ae) and a half-mer box C/D guide RNA paired with a ..
  70. ncbi Assembly and disassembly of spliceosomes along a specific pre-messenger RNP fiber
    E Kiseleva
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    EMBO J 13:6052-61. 1994
    ..In the nucleoplasmic pre-mRNP particle only one end of the RNP fiber was labeled by Y 12, presumably the 3' end; the anti-hnRNP antibody decorated the entire RNP fiber...
  71. ncbi Antibody penetration of viable human cells. I. Increased penetration of human lymphocytes by anti-RNP IgG
    J Ma
    Centre for Immunology, St Vincent s Hospital, Sydney, NSW, Australia
    Clin Exp Immunol 84:83-91. 1991
    ..peripheral blood lymphocytes (PBMC) were incubated with FITC-conjugated IgG fractions from sera containing anti-RNP (anti-RNP IgG), Ro(SS-A), La(SS-B) and dsDNA antibodies and control sera for 24 h...
  72. ncbi Anti-viral immunity induced by recombinant nucleoprotein of influenza A virus. II. Protection from influenza infection and mechanism of protection
    J P Tite
    Department of Experimental Immunobiology, Wellcome Biotech, Langley Court, Beckenham, Kent, U K
    Immunology 71:202-7. 1990
    Protection against influenza A virus infection in mice immunized with recombinant nucleoprotein (rNP) was studied...
  73. ncbi Pulse labeling of small nuclear ribonucleoproteins in vivo reveals distinct patterns of antigen recognition by human autoimmune antibodies
    D E Fisher
    Proc Natl Acad Sci U S A 81:3185-9. 1984
    Antibodies directed against small nuclear ribonucleoprotein ( snRNP ) particles are found in the Sm and RNP autoimmune sera from numerous patients with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD)...
  74. ncbi Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro/SSA-positive patients in rabbit hearts
    S Garcia
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil
    J Clin Invest 93:718-24. 1994
    ..3 mg/ml of anti-Ro/SSA- (or anti-Ro/La-) positive IgG (nine sera), anti-ribonucleoprotein (RNP)-positive IgG (five sera), or IgG fractions from normal donors (five sera)...
  75. ncbi Stiffened yeast telomerase RNA supports RNP function in vitro and in vivo
    Kevin J Lebo
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    RNA 18:1666-78. 2012
    ..Although accessory subunits of the telomerase ribonucleoprotein (RNP) complex function even when their binding sites are relocated on the yeast telomerase RNA, the physical nature of ..
  76. ncbi Phleboviruses encapsidate their genomes by sequestering RNA bases
    Donald D Raymond
    Life Sciences Institute, Department of Biological Chemistry, Cell and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 109:19208-13. 2012
    ..segmented negative-sense RNA genomes that are sequestered by a nucleocapsid protein (N) to form ribonucleoprotein (RNP) complexes of irregular, asymmetric structure, previously uncharacterized at high resolution...
  77. ncbi 5S rRNA and accompanying proteins in gonads: powerful markers to identify sex and reproductive endocrine disruption in fish
    Oihane Diaz de Cerio
    Laboratory of Cell Biology and Histology, Department of Zoology and Animal Cell Biology, School of Science and Technology, University of the Basque Country, PO Box 644, E 48080, Bilbao, Basque Country
    Environ Sci Technol 46:7763-71. 2012
    ..transcriptionally by transcription factor IIIA (TFIIIA), which upon transcription, binds 5S rRNA, forming 7S RNP. 5S rRNA can be stockpiled also in the form of 42S RNP bound to 42sp43...
  78. ncbi Altered posttranslational modification on U1 small nuclear ribonucleoprotein 68k in systemic autoimmune diseases detected by 2D Western blot
    Kouhei Nagai
    Clinical Proteomics and Molecular Medicine, St Marianna University Graduate School of Medicine, Miyamae, Kawasaki, Kanagawa, Japan
    Electrophoresis 33:2028-35. 2012
    Anti-ribonucleoprotein (anti-RNP) antibodies are one of the representative autoantibodies detectable in patients with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD)...
  79. ncbi Dendritic mRNA targeting and translation
    Stefan Kindler
    University Medical Center Hamburg Eppendorf, Institute for Human Genetics, Martinistr 52, 20246 Hamburg, Germany
    Adv Exp Med Biol 970:285-305. 2012
    ..For this purpose, mRNAs are packaged into large ribonucleoprotein (RNP) particles containing an array of trans-acting RNA-binding proteins...
  80. ncbi Discrete subcellular partitioning of human retrotransposon RNAs despite a common mechanism of genome insertion
    John L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:1712-25. 2010
    ..genome evolution much about their biology is unknown, including the processes of forming their ribonucleoprotein (RNP) particles and transporting them about the cell...
  81. ncbi Ciliate telomerase RNA loop IV nucleotides promote hierarchical RNP assembly and holoenzyme stability
    Aaron R Robart
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720 3200, USA
    RNA 16:563-71. 2010
    ..binds telomerase reverse transcriptase (TERT) and reconstitutes full activity of the minimal recombinant TERT+TER RNP, even when physically separated from the template...
  82. ncbi Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence
    Chengjun Li
    Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53711, USA
    Proc Natl Acad Sci U S A 107:4687-92. 2010
    ..We found that the presence of Tok07 PB2 protein in the ribonucleoprotein (RNP) complex allowed efficient viral RNA transcription in a minigenome assay and that RNP activity played an essential ..
  83. ncbi Novel Staufen1 ribonucleoproteins prevent formation of stress granules but favour encapsidation of HIV-1 genomic RNA
    Levon G Abrahamyan
    HIV 1 RNA Trafficking Laboratory, Lady Davis Institute for Medical Research Sir Mortimer B Davis Jewish General Hospital, Montreal, QC, H3T 1E2, Canada
    J Cell Sci 123:369-83. 2010
    ..The host protein, Staufen1 interacts directly with Gag and is found in ribonucleoprotein (RNP) complexes containing vRNA, which provides evidence that Staufen1 plays a role in vRNA selection and encapsidation...
  84. ncbi Three new members of the RNP protein family in Xenopus
    P J Good
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Nucleic Acids Res 21:999-1006. 1993
    Many RNP proteins contain one or more copies of the RNA recognition motif (RRM) and are thought to be involved in cellular RNA metabolism...
  85. ncbi Cytoplasmic ribonucleoprotein (RNP) bodies and their relationship to GW/P bodies
    Joanna J Moser
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Int J Biochem Cell Biol 42:828-43. 2010
    ..have focused their attention on elucidating the components and functional relevance of this ribonucleoprotein (RNP)-containing cytoplasmic microdomain to cellular and molecular biology, developmental and pathological processes, ..
  86. ncbi Exclusion of mRNPs and ribosomal particles from a thin zone beneath the nuclear envelope revealed upon inhibition of transport
    Karin Kylberg
    Department of Cell and Molecular Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Exp Cell Res 316:1028-38. 2010
    We have studied the nucleocytoplasmic transport of a specific messenger RNP (mRNP) particle, named Balbiani ring (BR) granule, and ribosomal RNP (rRNP) particles in the salivary glands of the dipteran Chironomus tentans...
  87. ncbi Identification and characterisation of a novel human RNA-binding protein
    J Badolato
    Bone and Mineral Research Division, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, N S W, Australia
    Gene 166:323-7. 1995
    ..nuclear RNA (hnRNA) into a mature message occurs within a number of different nuclear ribonucleoprotein (RNP) complexes which bind to the hnRNA and provide the machinery for these modifying events...
  88. ncbi The management of humeral shaft fractures with associated radial nerve palsy: a review of 117 cases
    Marko Bumbasirevic
    Clinical Centre for Serbia, Institute for Orthopaedic Surgery and Traumatology, Visegradska 26, Belgrade, Serbia
    Arch Orthop Trauma Surg 130:519-22. 2010
    ..management and outcomes of 117 consecutive patients with humeral shaft fractures and associated radial nerve palsy (RNP) treated over a 20-year period (1986-2006)...
  89. ncbi The modern RNP world of eukaryotes
    Lesley J Collins
    Allan Wilson Center for Molecular Ecology and Evolution, Palmerston North, New Zealand
    J Hered 100:597-604. 2009
    ..large cohort of proteins that partner RNAs; thus, the modern RNA world of eukaryotes is really a ribonucleoprotein (RNP) world...
  90. ncbi RNA triphosphatase and guanylyl transferase activities are associated with the RNA polymerase protein L of rinderpest virus
    M Gopinath
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
    J Gen Virol 90:1748-56. 2009
    Rinderpest virus (RPV) large (L) protein is an integral part of the ribonucleoprotein (RNP) complex of the virus that is responsible for transcription and replication of the genome...
  91. ncbi Intermolecular protein-RNA interactions revealed by 2D 31P-15N magic angle spinning solid-state NMR spectroscopy
    Stefan Jehle
    Computational and Structural Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    J Am Chem Soc 132:3842-6. 2010
    The structural investigation of large RNP complexes by X-ray crystallography can be a difficult task due to the flexibility of the RNA and of the protein-RNA interfaces, which may hinder crystallization...
  92. ncbi Ribosomal versus non-ribosomal cellular antigens: factors determining efficiency of indirect presentation to CD4+ T cells
    Mary Philip
    Committee on Cancer Biology, and Department of Pathology, The University of Chicago, Chicago, IL, USA
    Immunology 130:494-503. 2010
    ..targeted in autoimmune disease is circumscribed, and certain cellular components such as ribonucleoprotein (RNP) complexes are often targeted...
  93. ncbi NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein
    P W Howe
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 13:3873-81. 1994
    The RNP domain is a very common motif found in hundreds of proteins, including many protein components of the RNA processing machinery...
  94. ncbi Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita
    Shuang Li
    Department of Biochemistry and Molecular Biology, College of Life Sciences, Beijing Normal University, Beijing, China
    EMBO J 30:5010-20. 2011
    ..We report the structure of the Shq1-specific domain alone and in complex with H/ACA RNP proteins Cbf5, Nop10 and Gar1...
  95. ncbi SMN in spinal muscular atrophy and snRNP biogenesis
    Tristan H Coady
    Department of Veterinary Pathobiology, Bond Life Sciences Center, University of Missouri, Columbia, MO, USA
    Wiley Interdiscip Rev RNA 2:546-64. 2011
    Ribonucleoprotein (RNP) complexes function in nearly every facet of cellular activity...
  96. ncbi Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis
    Takashi Tanaka
    Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 108:10579-84. 2011
    In the male germline in mammals, chromatoid bodies, a specialized assembly of cytoplasmic ribonucleoprotein (RNP), are structurally evident during meiosis and haploidgenesis, but their developmental origin and regulation remain elusive...
  97. ncbi Heterogeneous nuclear ribonucleoprotein hrp36 acts as an alternative splicing repressor in Litopenaeus vannamei Dscam
    Chung Wei Lee
    Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan
    Dev Comp Immunol 36:10-20. 2012
    ..two copies of the RNA recognition motif (RRM), a C-terminal glycine-rich domain (GRD), the highly degenerate RNP consensus sequences RNP-1 and RNP-2, and two RGG boxes...
  98. ncbi Functional importance of telomerase pseudoknot revealed by single-molecule analysis
    Mariana Mihalusova
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 108:20339-44. 2011
    Telomerase ribonucleoprotein (RNP) employs an RNA subunit to template the addition of telomeric repeats onto chromosome ends...
  99. ncbi Co-transcriptional architecture in a Y loop in Drosophila melanogaster
    Juliet L Redhouse
    Department of Physiology, Development and Neuroscience, University of Cambridge, UK
    Chromosoma 120:399-407. 2011
    ..By labelling ribonucleo-protein (RNP) components, the loop chromatin and nascent transcripts in Y loop C, we reveal a highly structured organisation of ..
  100. ncbi Translocation of a specific premessenger ribonucleoprotein particle through the nuclear pore studied with electron microscope tomography
    H Mehlin
    Department of Molecular Genetics, Karolinska Institutet, Stockholm, Sweden
    Cell 69:605-13. 1992
    A specific premessenger ribonucleoprotein (RNP) particle in the salivary glands of the dipteran Chironomus tentans was studied with electron microscope tomography during translocation from the cell nucleus to the cytoplasm...
  101. ncbi Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function
    D A Wassarman
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510 8024
    Mol Cell Biol 11:3432-45. 1991
    The human 7SK ribonucleoprotein (RNP) has been analyzed to determine its RNA secondary structure and protein constituents...

Research Grants93

  1. Structure and Function in Catalytic RNP Assembly
    Mark Foster; Fiscal Year: 2009
    ..and dynamic insights into how proteins modulate RNA structure and function in a catalytic ribonucleoprotein (RNP) complex...
  2. Immune Response to Small Nuclear Ribonucleoprotein Autoantigens
    Robert Hoffman; Fiscal Year: 2007
    ..Immunity to snRNP autoantigens, including the Smith (Sm) and the U1-70RD polypeptide of the ribonucleoprotein (RNP) antigen, appears to have a central role in these diseases...
  3. The influenza A virus nucleoprotein: structure and function
    Yizhi Tao; Fiscal Year: 2009
    ..eight segments of (-)RNA that are encapsidated in distinct double-helical structures called the ribonucleoprotein (RNP) complexes. The nucleoprotein (NP), the major protein component of RNPs, binds along genomic RNA at a 24nt interval...
  4. The influenza A virus nucleoprotein: structure and function
    YIZHI JANE contact TAO; Fiscal Year: 2010
    ..eight segments of (-)RNA that are encapsidated in distinct double-helical structures called the ribonucleoprotein (RNP) complexes. The nucleoprotein (NP), the major protein component of RNPs, binds along genomic RNA at a 24nt interval...
  5. SPLICING OF MRNA PRECURSORS
    Michael R Green; Fiscal Year: 2010
    ..Pre- mRNA splicing occurs in a ribonucleoprotein (RNP) complex called the spliceosome, which is composed of a large number of proteins and multiple U small nuclear RNP ..
  6. Small RNP Mediators of Gene Expression
    JOAN STEITZ; Fiscal Year: 2009
    ..These studies will illuminate a variety of human disease processes that can be traced to perturbations in small RNP biogenesis, functions and associations.
  7. Small RNP Mediators of Gene Expression
    Joan A Steitz; Fiscal Year: 2010
    ..These studies will illuminate a variety of human disease processes that can be traced to perturbations in small RNP biogenesis, functions and associations.
  8. Small RNP Mediators of Gene Expression
    JOAN STEITZ; Fiscal Year: 2007
    ..These studies will illuminate a variety of human disease processes that can be traced to perturbations in small RNP biogenesis, functions and associations.
  9. Structure and dynamics of the Tetrahymena telomerase ribonucleoprotein
    Michael D Stone; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The telomerase ribonucleoprotein (RNP) is required for maintaining telomeres, the specialized nucleoprotein structures that protect eukaryotic chromosome ends from aberrant processing and deleterious ..
  10. Spinal muscular atrophy: a novel role of SMN in axonal ribonucleoprotein complexe
    Wilfried Rossoll; Fiscal Year: 2007
    ..mainly on the essential role of SMN in the efficient assembly and remodeling of spliceosomal ribonucleoprotein (RNP) complexes in all cell types...
  11. MECHANISMS OF HEPADNAVIRUS ASSEMBLY AND REPLICATION
    Jianming Hu; Fiscal Year: 2003
    ..A critical early step in viral replication is the assembly of a ribonucleoprotein (RNP) complex comprised of the viral reverse transcriptase (RT) and pgRNA, which triggers both the assembly of ..
  12. Translational regulation of cellular morphogenesis in early Drosophila embryos
    Paul M Macdonald; Fiscal Year: 2010
    ..regulation and that dFMRP and TRAL function during the MZT within dynamic cytoplasmic ribonucleoprotein (RNP) bodies (MZT bodies)...
  13. Molecular Mechanisms of Rhabdovirus Entry
    Sean P J Whelan; Fiscal Year: 2010
    ..imaging approaches to probe the relationships between hemifusion, fusion pore formation and transfer of the RNP across a lipid bilayer in vitro...
  14. Structure and Function of Ribonucleoprotein Complexes Modulating HIV Replication
    Tariq M Rana; Fiscal Year: 2010
    ..P-TEFb is inactivated by sequestration into a large ribonucleoprotein (RNP) complex containing the small nuclear RNA, 7SK, and the Hexim1 protein...
  15. Structure and Function of Human Telomerase
    Juli Feigon; Fiscal Year: 2009
    ..3' half contains the elements essential for localization, processing, TR accumulation, and binding the H/ACA RNP proteins...
  16. Structure and Function of Human Telomerase
    JULI F FEIGON; Fiscal Year: 2010
    ..3'half contains the elements essential for localization, processing, TR accumulation, and binding the H/ACA RNP proteins...
  17. Assembly of the AI5-beta Group I Intron RNP
    Edward Turk; Fiscal Year: 2007
    This proposal will elucidate the mechanisms of ribonucleoprotein (RNP) biogenesis...
  18. Nuclear bodies and ribonucleoprotein biogenesis
    MICHAEL HEBERT; Fiscal Year: 2009
    ..body organization between different cell types is a manifestation of the most efficient nuclear configuration for RNP biogenesis...
  19. Nuclear bodies and ribonucleoprotein biogenesis
    Michael D Hebert; Fiscal Year: 2010
    ..body organization between different cell types is a manifestation of the most efficient nuclear configuration for RNP biogenesis...
  20. Structure and Function in Catalytic RNP Assembly
    Mark Foster; Fiscal Year: 2007
    ..and dynamic insights into how proteins modulate RNA structure and function in a catalytic ribonucleoprotein (RNP) complex...
  21. FUNCTION AND METABOLISM OF RNA
    Norman R Pace; Fiscal Year: 2010
    ..RNase P is an unusual enzyme in that it is a ribonucleoprotein (RNP) and its catalytic component is comprised of RNA instead of the usual protein...
  22. TELOMERASE RNP STRUCTURE/FUNCTION
    DOROTHY SHIPPEN; Fiscal Year: 2001
    ..The primary mechanism for synthesizing teleomeres is telomerase, an unusual ribonucleoprotein (RNP) with reverse transcriptase activity...
  23. REGULATION OF MITOCHONDRIAL BIOGENESIS IN YEAST
    RONALD BUTOW; Fiscal Year: 2007
    ..functions in group I intron splicing, and in particular, to resolve excised group I introns from ribonucleoprotein (RNP) splicing complexes. This model will be tested, including the notion that SUV3-1 is a compromised RNA helicase...
  24. STRUCTURE AND ASSEMBLY OF 30 S CENTRAL DOMAIN RNPS
    James Williamson; Fiscal Year: 2003
    ..hope to reveal the specific mechanism of central domain assembly, as well as about general principles of RNP assembly. The Specific Aims are: 1) Determine the structure of a 3-way junction subfragment of the S15 binding site...
  25. RNase P as a Model for Ribonucleoprotein Assembly
    STACY CHAMBERLIN; Fiscal Year: 2005
    Ribonucleoprotein (RNP) complexes are integral to cellular function and control of RNP assembly is an important cellular regulatory mechanism and an attractive therapeutic target...
  26. GROUP II INTRON RNA SPLICING AND MOBILITY
    Alan Lambowitz; Fiscal Year: 2002
    ..target-DNA primed reverse transcription mechanisms involving a novel intron-encoded DNA endonuclease, which is an RNP complex containing the intron- encoded protein and the excised intron RNA...
  27. Group II Intron Mobility and Gene Targeting
    Alan Lambowitz; Fiscal Year: 2006
    ..These introns use a novel mobility mechanism mediated by an RNP particle that is formed during RNA splicing and contains the intron-encoded reverse transcriptase and the excised ..
  28. HORMONAL REGULATION OF MESSENGER RNA STABILITY
    Daniel R Schoenberg; Fiscal Year: 2010
    ..This is the first step toward deciphering the 'RNP code'for PMR1-mRNA decay...
  29. Crystallizing Hepatitis B Virus Reverse Transcriptase
    Hwai Chen Guo; Fiscal Year: 2006
    ..A critical early step in HBV replication is the assembly of a specific ribonucleoprotein (RNP) complex between the viral reverse transcriptase (RT) and a specific RNA signal called Epsilon, located at the 5' ..
  30. IMMUNE MECHANISMS IN PRISTANE INDUCED LUPUS NEPHRITIS
    Westley Reeves; Fiscal Year: 2003
    ..This syndrome is characterized by disease-specific autoantibody production (anti-Sm, RNP, Su, ribosomal P, double stranded DNA), hypergammaglobulinemia, and severe immune complex-mediated ..
  31. SPLICING OF MRNA PRECURSORS
    Michael Green; Fiscal Year: 2007
    ..Pre-mRNA splicing occurs in a ribonucleoprotein (RNP) complex called the spliceosome, which is composed of a large number of proteins and multiple U small nuclear RNP ..
  32. POLYADENYLATION AND TRANSLATIONAL CONTROL
    Joel D Richter; Fiscal Year: 2010
    ..a cascade of events leads to CPEB phosphorylation, an event that expels PARN from the ribonucleoprotein (RNP) complex and allows Gld2-catalyzed default poly(A) tail growth...
  33. POLYADENYLATION AND TRANSLATIONAL CONTROL
    Joel Richter; Fiscal Year: 2009
    ..a cascade of events leads to CPEB phosphorylation, an event that expels PARN from the ribonucleoprotein (RNP) complex and allows Gld2-catalyzed default poly(A) tail growth...