Gene Symbol: RNF39
Description: ring finger protein 39
Alias: HZF, HZFW, LIRF, RING finger protein 39, LTP (long-term potentiation) induced RING finger protein, protein HZFw
Species: human
Products:     RNF39

Top Publications

  1. Kurata R, Nakaoka H, Tajima A, Hosomichi K, Shiina T, Meguro A, et al. TRIM39 and RNF39 are associated with Behçet's disease independently of HLA-B?51 and -A?26. Biochem Biophys Res Commun. 2010;401:533-7 pubmed publisher
    ..Our findings suggest that RNF39 and TRIM39 are involved in the etiology of BD.
  2. Tsuboi D, Kuroda K, Tanaka M, Namba T, Iizuka Y, Taya S, et al. Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity. Nat Neurosci. 2015;18:698-707 pubmed publisher
    ..to screen for DISC1 interactors and identified several RNA-binding proteins, such as hematopoietic zinc finger (HZF), that act as components of RNA-transporting granules...
  3. Weng L, Taylor K, Chen Y, Sopko G, Kelsey S, Bairey Merz C, et al. Genetic loci associated with nonobstructive coronary artery disease in Caucasian women. Physiol Genomics. 2016;48:12-20 pubmed publisher
    ..One genetic marker, single nucleotide polymorphism (SNP) rs2301753 on chromosome 6 in RNF39, achieved chip-wide significance for nonobstructive CAD (P < 9.5 × 10(-7))...
  4. Hidaka M, Caruana G, Stanford W, Sam M, Correll P, Bernstein A. Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells. Mech Dev. 2000;90:3-15 pubmed
    Using an expression gene trapping strategy, we have identified and characterized two novel hematopoietic genes, Hzf and Hhl...
  5. Mick E, McGough J, Deutsch C, Frazier J, Kennedy D, Goldberg R. Genome-wide association study of proneness to anger. PLoS ONE. 2014;9:e87257 pubmed publisher
    ..These results suggest that signaling pathways regulating intracellular calcium homeostasis, which are relevant to memory, learning, and neuronal survival, may in part underlie the expression of Angry Temperament. ..
  6. Morin A, Laviolette M, Pastinen T, Boulet L, Laprise C. Combining omics data to identify genes associated with allergic rhinitis. Clin Epigenetics. 2017;9:3 pubmed publisher
    ..05) including one with both allergic rhinitis with or without asthma (RNF39)...
  7. Maltby V, Lea R, Sanders K, White N, Benton M, Scott R, et al. Differential methylation at MHC in CD4+ T cells is associated with multiple sclerosis independently of HLA-DRB1. Clin Epigenetics. 2017;9:71 pubmed publisher
    ..In addition, we identified a large independent DMR at MHC, whereby 11 CpGs in RNF39 were hypermethylated in MS cases compared to controls (max. ?beta?=?0.19, P?=?2.1 × 10-4)...
  8. Coriton O, Lepourcelet M, Hampe A, Galibert F, Mosser J. Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes. Mamm Genome. 2000;11:1127-31 pubmed
    ..we identify 21 different mRNAs mainly expressed in testis, and characterize five different transcription units, HZFw, HZFc, HCGV, HTEX6, and HTEX4...
  9. Matsuo R, Asada A, Fujitani K, Inokuchi K. LIRF, a gene induced during hippocampal long-term potentiation as an immediate-early gene, encodes a novel RING finger protein. Biochem Biophys Res Commun. 2001;289:479-84 pubmed
    We describe here an LTP-induced gene, LIRF, which encodes a novel protein with RING finger and B30.2 domains in its N- and C-terminal portions, respectively...

More Information


  1. Van Manen D, Kootstra N, Boeser Nunnink B, Handulle M, van t Wout A, Schuitemaker H. Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection. AIDS. 2009;23:19-28 pubmed publisher
    ..SNPs) in the gene regions of HLA-C and HCP5 to be associated with viral load at set point and SNPs in the RNF39/ZNRD1 gene region to be associated with HIV-1 disease course...
  2. Limou S, Le Clerc S, Coulonges C, Carpentier W, Dina C, Delaneau O, et al. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). J Infect Dis. 2009;199:419-26 pubmed publisher
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection. ..
  3. Trachtenberg E, Bhattacharya T, Ladner M, Phair J, Erlich H, Wolinsky S. The HLA-B/-C haplotype block contains major determinants for host control of HIV. Genes Immun. 2009;10:673-7 pubmed publisher
    ..polymorphisms, which associated with either viral set point (HCP5 and 5' HLA-C) or with HIV disease progression (RNF39 and ZNRD1)...
  4. Orimo A, Yamagishi T, Tominaga N, Yamauchi Y, Hishinuma T, Okada K, et al. Molecular cloning of testis-abundant finger Protein/Ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC. Biochem Biophys Res Commun. 2000;276:45-51 pubmed
    ..2 proteins such as RFP, RFB30/HERF1, AFP, and HZF had been localized. These findings demonstrate that several RBCC-B30...
  5. Cree B, Rioux J, McCauley J, Gourraud P, Goyette P, McElroy J, et al. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. PLoS ONE. 2010;5:e11296 pubmed publisher
    ..A MHC Class I locus contributes to MS susceptibility independently of the HLA-DRB1*15:01 haplotype. ..
  6. Das S, Raj L, Zhao B, Kimura Y, Bernstein A, Aaronson S, et al. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell. 2007;130:624-37 pubmed
    ..We show here that hematopoietic zinc finger (Hzf), a zinc-finger-containing p53 target gene, modulates p53 transactivation functions in an autoregulatory feedback ..