Gene Symbol: RNF185
Description: ring finger protein 185
Alias: E3 ubiquitin-protein ligase RNF185, BSK65-MONO1, BSK65-MONO2, BSK65-PANC1, BSK65-PANC2, BSK65-TEST1, BSK65-TEST2, BSK65-TEST3, RING-type E3 ubiquitin transferase RNF185
Species: human
Products:     RNF185

Top Publications

  1. Qiu D, Wang Q, Wang Z, Chen J, Yan D, Zhou Y, et al. RNF185 modulates JWA ubiquitination and promotes gastric cancer metastasis. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1552-1561 pubmed publisher
    ..In the present study, we found that an E3 ubiquitin ligase, RNF185, directly interacted with JWA and promoted its ubiquitination at the K158 site, resulting in subsequent ..
  2. Hülsmann J, Kravic B, Weith M, Gstaiger M, Aebersold R, Collins B, et al. AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation. Mol Cell Proteomics. 2018;17:1295-1307 pubmed publisher
    ..a large detection range from abundant p97 cofactors to pathway-specific partners and individual ligases such as RNF185 and MUL1 that were trapped in p97-E578Q complexes...
  3. Tang F, Wang B, Li N, Wu Y, Jia J, Suo T, et al. RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. PLoS ONE. 2011;6:e24367 pubmed publisher
    ..Here we show that human RNF185 is a mitochondrial ubiquitin E3 ligase that regulates selective mitochondrial autophagy in cultured cells...
  4. El Khouri E, Le Pavec G, Toledano M, Delaunay Moisan A. RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR). J Biol Chem. 2013;288:31177-91 pubmed publisher
    ..b>RNF185 is a RING domain-containing polypeptide homologous to RNF5...
  5. Wang Q, Huang L, Hong Z, Lv Z, Mao Z, Tang Y, et al. The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response. PLoS Pathog. 2017;13:e1006264 pubmed publisher
    ..Here, we reported that the ER ubiquitin ligase RNF185 interacted with cGAS during HSV-1 infection...
  6. Zhou Y, Shang H, Zhang C, Liu Y, Zhao Y, Shuang F, et al. The E3 ligase RNF185 negatively regulates osteogenic differentiation by targeting Dvl2 for degradation. Biochem Biophys Res Commun. 2014;447:431-6 pubmed publisher
    ..b>RNF185 was identified as a candidate of endogenous suppressors of osteogenic specification in human mesenchymal stem ..