Gene Symbol: RNF14
Description: ring finger protein 14
Alias: ARA54, HFB30, HRIHFB2038, TRIAD2, E3 ubiquitin-protein ligase RNF14, androgen receptor associated protein 54
Species: human
Products:     RNF14

Top Publications

  1. Horzmann K, Reidenbach L, Thanki D, Winchester A, Qualizza B, Ryan G, et al. Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures. J Proteomics. 2018;186:71-82 pubmed publisher
    ..of cytochrome P450 family 17 subfamily A member 1 (cyp17a1), glyoxalase I (glo1), ring finger protein 14 (rnf14), salt inducible kinase 2 (sik2), tetratricopeptide domain 3 (ttc3), and tumor protein D52 like 1 (tpd52l1) at ..
  2. Wang X, Wei W, Wang W, Zhao X, Guo H, Fang D. RING finger proteins are involved in the progression of barrett esophagus to esophageal adenocarcinoma: a preliminary study. Gut Liver. 2014;8:487-94 pubmed publisher
    ..4-fold higher, respectively, than that in NE, and the expression of RNF24, RNF130, RNF141, RNF139, RNF11, RNF14, and RNF159 was upregulated more than 2-fold compared with NE...
  3. Yang Z, Chang Y, Miyamoto H, Ni J, Niu Y, Chen Z, et al. Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth. Mol Endocrinol. 2007;21:343-58 pubmed
    ..Here we describe transgelin as the first ARA54-associated negative modulator for AR...
  4. Wu B, Piloto S, Zeng W, Hoverter N, Schilling T, Waterman M. Ring Finger Protein 14 is a new regulator of TCF/?-catenin-mediated transcription and colon cancer cell survival. EMBO Rep. 2013;14:347-55 pubmed publisher
    ..Here we discover Ring Finger Protein 14 (RNF14) as a new binding partner for all TCF/LEF transcription factors...
  5. Ting H, Bao B, Hsu C, Lee Y. Androgen-receptor coregulators mediate the suppressive effect of androgen signals on vitamin D receptor activity. Endocrine. 2005;26:1-9 pubmed
    ..Among the AR coregulators we tested, ARA54, ARA70, supervillin, and gelsolin were found to enhance VDR transactivation...
  6. He B, Wilson E. Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs. Mol Cell Biol. 2003;23:2135-50 pubmed
    ..The data suggest a model whereby coactivator recruitment to the receptor AF2 surface is initiated by complementary charge interactions that reflect a reversal of the acidic activation domain-coactivator interaction model. ..
  7. Miyamoto H, Rahman M, Takatera H, Kang H, Yeh S, Chang H, et al. A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth. J Biol Chem. 2002;277:4609-17 pubmed
    ..AR) regulates target genes via a mechanism involving coregulators such as androgen receptor-associated 54 (ARA54)...
  8. Kikuchi H, Uchida C, Hattori T, Isobe T, Hiramatsu Y, Kitagawa K, et al. ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells. Carcinogenesis. 2007;28:1752-8 pubmed
    ..b>ARA54 is an androgen receptor (AR) co-activator that enhances AR-dependent transcriptional activation...
  9. Kang H, Yeh S, Fujimoto N, Chang C. Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. J Biol Chem. 1999;274:8570-6 pubmed
    ..screening followed by mammalian cell analyses, we identified a novel ligand-dependent AR-associated protein, ARA54, which consists of 474 amino acids with a molecular mass of 54 kDa...

More Information


  1. Long D, Wang P, Sun Y, Chen R, Wu Y. Neuropathy Target Esterase Is Degraded by the Ubiquitin-Proteasome Pathway with ARA54 as the Ubiquitin Ligase. Biochemistry. 2015;54:7385-92 pubmed publisher
    ..Here we further reveal that androgen receptor-associated protein 54 (ARA54) regulated the ubiquitin-proteasome degradation of NTE...
  2. Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M. Selection system for genes encoding nuclear-targeted proteins. Nat Biotechnol. 1998;16:1338-42 pubmed
    ..We propose that NTT is an efficient method for isolating cDNAs that encode nuclear targeted proteins that can be applied to the retrieval of novel nuclear proteins and to annotate gene function. ..
  3. Lin D, Fang H, Ma A, Huang Y, Pu Y, Jenster G, et al. Negative modulation of androgen receptor transcriptional activity by Daxx. Mol Cell Biol. 2004;24:10529-41 pubmed
    ..Together, these findings not only provide a novel role of Daxx in controlling AR transactivation activity but also uncover the mechanism underlying sumoylation-dependent transcriptional repression of the AR. ..
  4. Mestayer C, Blanchere M, Jaubert F, Dufour B, Mowszowicz I. Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines. Prostate. 2003;56:192-200 pubmed
    ..AR and coactivators ARA54, ARA55, ARA70, and SRC1 RNA were analyzed by RT-PCR in normal and tumoral tissues of the same prostate, in ..
  5. He B, Minges J, Lee L, Wilson E. The FXXLF motif mediates androgen receptor-specific interactions with coregulators. J Biol Chem. 2002;277:10226-35 pubmed
    ..Here we show that FXXLF motifs are present in previously reported AR coactivators ARA70/RFG, ARA55/Hic-5, and ARA54, which account for their selection in yeast two-hybrid screens...
  6. Laganiere J, Deblois G, Giguere V. Functional genomics identifies a mechanism for estrogen activation of the retinoic acid receptor alpha1 gene in breast cancer cells. Mol Endocrinol. 2005;19:1584-92 pubmed
  7. Pick E, Lau O, Tsuge T, Menon S, Tong Y, Dohmae N, et al. Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. Mol Cell Biol. 2007;27:4708-19 pubmed
    ..Overexpression of DET1 inhibits UV-induced CDT1 degradation in cultured cells. These findings demonstrate that the conserved DET1 complex modulates Cul4A functions by a novel mechanism. ..
  8. Ueda T, Mawji N, Bruchovsky N, Sadar M. Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. J Biol Chem. 2002;277:38087-94 pubmed
    ..7) Ligand-independent activation of the AR did not occur by a mechanism of overexpression of either solely wild-type SRC-1 or mutant SRC-1 that mimics its phosphorylated form. ..
  9. Xu K, Shimelis H, Linn D, Jiang R, Yang X, Sun F, et al. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Cancer Cell. 2009;15:270-82 pubmed publisher
    ..Our data suggest that RNF6-induced ubiquitination may regulate AR transcriptional activity and specificity through modulating cofactor recruitment. ..
  10. Ito K, Adachi S, Iwakami R, Yasuda H, Muto Y, Seki N, et al. N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. Eur J Biochem. 2001;268:2725-32 pubmed
    ..we performed yeast two-hybrid screening for protein(s) interacting with UBE2E2, and two RING-finger proteins, ARA54 and RNF8, were identified...
  11. Wang J, Zhang W, Ji W, Liu X, Ouyang G, Xiao W. The von hippel-lindau protein suppresses androgen receptor activity. Mol Endocrinol. 2014;28:239-48 pubmed publisher
    ..Our data reveal a novel function of pVHL in the regulation of AR transcription activity, which may expand the scope of pVHL in tumor suppression and provide mechanistic insight into prostate cancer initiation and progression. ..
  12. Ambivero C, Cilenti L, Main S, Zervos A. Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP. Cell Signal. 2014;26:2921-9 pubmed publisher
    ..In addition, the interaction of GABARAP with Mulan-Ube2E3 supports the role of Mulan as an important regulator of mitophagy and provides a plausible mechanism for its function in this process. ..
  13. Ueki N, Seki N, Yano K, Masuho Y, Saito T, Muramatsu M. Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif. Biochim Biophys Acta. 1999;1445:232-6 pubmed
    A human cDNA, HFB30, encoding a novel protein that contains a RING finger (C3HC4-type zinc finger) motif was isolated. This cDNA clone consists of 3056 nucleotides and encodes an open reading frame of a 474 amino acid protein...
  14. Yang Z, Chang Y, Miyamoto H, Yeh S, Yao J, di Sant agnese P, et al. Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54. Endocrinology. 2007;148:1340-9 pubmed
    ..heterogeneous nuclear ribonucleoprotein (hnRNP) A1 as an associated negative modulator for the AR coregulator ARA54. hnRNP A1 selectively suppressed ARA54-enhanced wild-type and mutant AR transactivation via interruption of AR-..
  15. Lan K, Hseh C, Lu S, Chang S, Shyr C, Chen Y, et al. Expression of androgen receptor co-regulators in the testes of men with azoospermia. Fertil Steril. 2008;89:1397-405 pubmed
    ..However, the levels of expression of ARA54 mRNA were significantly lower and ARA55 mRNA was significantly higher in specimens from men with nonobstructive ..