RNASE2

Summary

Gene Symbol: RNASE2
Description: ribonuclease A family member 2
Alias: EDN, RAF3, RNS2, non-secretory ribonuclease, RNase 2, RNase UpI-2, eosinophil-derived neurotoxin, ribonuclease 2, ribonuclease A F3, ribonuclease US, ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
Species: human
Products:     RNASE2

Top Publications

  1. Yang D, Chen Q, Su S, Zhang P, Kurosaka K, Caspi R, et al. Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J Exp Med. 2008;205:79-90 pubmed publisher
    Eosinophil-derived neurotoxin (EDN) is an eosinophil granule-derived secretory protein with ribonuclease and antiviral activity. We have previously shown that EDN can induce the migration and maturation of dendritic cells (DCs)...
  2. Gleich G, Loegering D, Bell M, Checkel J, Ackerman S, McKean D. Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease. Proc Natl Acad Sci U S A. 1986;83:3146-50 pubmed
    Eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) were isolated from lysates of human eosinophil granules by gel filtration and ion exchange chromatography on heparin-Sepharose...
  3. Sur S, Glitz D, Kita H, Kujawa S, Peterson E, Weiler D, et al. Localization of eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophilic leukocytes. J Leukoc Biol. 1998;63:715-22 pubmed
    Eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) are generally regarded as eosinophil-specific proteins. We tested whether EDN and ECP are present in mature neutrophils...
  4. Zhang J, Rosenberg H. Sequence variation at two eosinophil-associated ribonuclease loci in humans. Genetics. 2000;156:1949-58 pubmed
    ..Here we present sequences of 2417 nucleotides at the two EAR loci, the eosinophil-derived neurotoxin (EDN, RNase 2) and eosinophil cationic protein (ECP, RNase 3), from >50 human individuals...
  5. Yang D, Rosenberg H, Chen Q, Dyer K, Kurosaka K, Oppenheim J. Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells. Blood. 2003;102:3396-403 pubmed
    ..EDN was not chemotactic for leukocytes other than DCs. Mouse eosinophil-associated RNase 2 (mEAR2), one of a cluster of divergent orthologs of human EDN, was also chemotactic for human as well as mouse ..
  6. Hamann K, Ten R, Loegering D, Jenkins R, Heise M, Schad C, et al. Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily. Genomics. 1990;7:535-46 pubmed
    ..Alignment of EDN (RNS2) and ECP (RNS3) gene sequences demonstrated remarkable nucleotide similarities in noncoding sequences, introns, and ..
  7. Kim Y, Kumaraswami V, Choi E, Mu J, Follmann D, Zimmerman P, et al. Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia. Am J Trop Med Hyg. 2005;73:125-30 pubmed
    Because eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) are critical in the pathogenesis of tropical pulmonary eosinophilia (TPE), we analyzed genetic polymorphisms of both in 181 individuals from southern India ..
  8. Yang D, Chen Q, Rosenberg H, Rybak S, Newton D, Wang Z, et al. Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation. J Immunol. 2004;173:6134-42 pubmed
    ..Eosinophil granules contain an antimicrobial protein known as eosinophil-derived neurotoxin (EDN), which belongs to the RNase A superfamily. EDN has antiviral and chemotactic activities in vitro...
  9. Goto T, Morioka J, Inamura H, Yano M, Kodaira K, Igarashi Y, et al. Urinary eosinophil-derived neurotoxin concentrations in patients with atopic dermatitis: a useful clinical marker for disease activity. Allergol Int. 2007;56:433-8 pubmed
    It has been reported that measurements of eosinophil-derived neurotoxin (EDN) may be useful for identifying eosinophil activities in allergic diseases including atopic dermatitis...

More Information

Publications147 found, 100 shown here

  1. Kobayashi T, Soma T, Noguchi T, Nakagome K, Nakamoto H, Kita H, et al. ATP drives eosinophil effector responses through P2 purinergic receptors. Allergol Int. 2015;64 Suppl:S30-6 pubmed publisher
    ..membrane, adhesion to rh-ICAM-1, superoxide generation, and degranulation of eosinophil-derived neurotoxin (EDN). oATP and anti-P2Y2 significantly reduced these eosinophil responses...
  2. Davalieva K, Kiprijanovska S, Maleva Kostovska I, Stavridis S, Stankov O, Komina S, et al. Comparative Proteomics Analysis of Urine Reveals Down-Regulation of Acute Phase Response Signaling and LXR/RXR Activation Pathways in Prostate Cancer. Proteomes. 2017;6: pubmed publisher
    ..tumor suppressors, and multifunctional proteins with highly confirmed involvement in PCa, while 9 (AZU1, IGHG1, RNASE2, PZP, REG1A, AMY1A, AMY2A, ACTG2, COL18A1) have been associated with different cancers, but not with PCa so far, ..
  3. Li H, Fan L, Zhu S, Shin M, Lu F, Qu J, et al. Epilation induces hair and skin pigmentation through an EDN3/EDNRB-dependent regenerative response of melanocyte stem cells. Sci Rep. 2017;7:7272 pubmed publisher
    ..The findings suggest that EDN/EDNRB signaling may serve as a potential therapeutic target to promote repigmentation in hypopigmentation disorders. ..
  4. McIntyre N, Solari E, Grimm R, E Lerro L, E Gonzales J, Mundy P. A Comprehensive Examination of Reading Heterogeneity in Students with High Functioning Autism: Distinct Reading Profiles and Their Relation to Autism Symptom Severity. J Autism Dev Disord. 2017;47:1086-1101 pubmed publisher
    ..Autism diagnostic observation schedule, 2nd edn, Western Psychological Services, Torrance, CA, 2012), analyses were conducted to determine if significant ..
  5. Ta L, Gosa L, Nathanson D. Biosafety and Biohazards: Understanding Biosafety Levels and Meeting Safety Requirements of a Biobank. Methods Mol Biol. 2019;1897:213-225 pubmed publisher
    ..the Center of Disease Control and Prevention (CDC) (Biosafety in microbiological and biomedical laboratories, 5th edn. HHS publication no. (CDC) 21-1112. https://www.cdc.gov/biosafety/publications/bmbl5/bmbl.pdf ...
  6. Jiang L, Sun B, Zheng C, Yang G. The antitumour effects of eudesmin on lung cancer by inducing apoptosis via mitochondria-mediated pathway in the tumour cells. Pharm Biol. 2017;55:2259-2263 pubmed publisher
    ..Eudesmin (EDN) is a type of limonoid which also possesses various activities...
  7. Lu H, Xie R, Lin R, Zhang C, Xiao X, Li L, et al. Vitamin D-deficiency induces eosinophil spontaneous activation. Cell Immunol. 2017;322:56-63 pubmed publisher
    ..including major basic protein (MBP), Eo peroxidase (EPX), Eo cationic protein (ECP) and Eo-derived neurotoxin (EDN), were assessed in the culture supernatant and in EoL-1 cells...
  8. Tan M, Reich J, Hart L, Thuma P, Grigorenko E. Examining the specific effects of context on adaptive behavior and achievement in a rural African community: six case studies from rural areas of Southern province, Zambia. J Autism Dev Disord. 2014;44:271-82 pubmed publisher
    ..The Vineland-II (Sparrow et al. in Vineland Adaptive Behavior Scales, Second edn. AGS Publishing, Circle Pines, MN, 2005) was translated into Chitonga and adapted to the setting of rural Southern ..
  9. Aydin A, Vural P, Dogru Abbasoglu S, Cil E. The endothelin 1 and endothelin receptor A gene polymorphisms increase the risk of developing papillary thyroid cancer. Mol Biol Rep. 2019;46:199-205 pubmed publisher
    The endothelin (EDN) axis (EDN1 and EDN1 receptor A, EDNRA) is involved in cellular growth, differentiation, invasiveness, and tumor progression in several cancers...
  10. Levin A, Gui H, Hernandez Pacheco N, Yang M, Xiao S, Yang J, et al. Integrative approach identifies corticosteroid response variant in diverse populations with asthma. J Allergy Clin Immunol. 2018;: pubmed publisher
    ..023, P = .029, and P = .041). RNA sequencing analysis found the rs3827907 C-allele to be associated with lower RNASE2 expression (P = 6.10 × 10-4)...
  11. Ugur K, Acar M, Ozol D, Dagli E, Oznur M, Köşüş A, et al. Gene Expression Profiles of Tumor Necrosis Factor-α and Endothelin-1 in Obstructive Sleep Apnea. ORL J Otorhinolaryngol Relat Spec. 2019;81:16-23 pubmed publisher
    ..to observe the relationship between the gene expression profiles of tumor necrosis factor (TNF)-α and endothelin (EDN)-1 and obstructive sleep apnea (OSA)...
  12. Zhang Q, Guo J, Zhu H, Zhong Y, Pan T, Yin H, et al. Endovascular Denervation: A New Approach for Cancer Pain Relief?. J Vasc Interv Radiol. 2018;29:1639-1644 pubmed publisher
    To evaluate the effects of endovascular denervation (EDN) on abdominal cancer pain relief. From April 2017 to February 2018, 7 cancer patients (2 males and 5 females) were enrolled in this study...
  13. Páez Osuna F, Bojórquez Leyva H, Bergés Tiznado M, Rubio Hernández O, Fierro Sañudo J, Ramírez Rochín J, et al. Heavy metals in waters and suspended sediments affected by a mine tailing spill in the upper San Lorenzo River, Northwestern México. Bull Environ Contam Toxicol. 2015;94:583-8 pubmed publisher
    ..L(-1)) and were less than the upper limits established by UNEP (Water quality for ecosystem and human health, 2nd edn. United Nations Environment Programme Global Environment Monitoring System/Water Programme, Burlington, 2008), EPA (..
  14. Chebib N, Archer F, Bobet Erny A, Leroux C, Cottin V. Dysregulation of the endothelin pathway in lymphangioleiomyomatosis with no direct effect on cell proliferation and migration. Sci Rep. 2018;8:14698 pubmed publisher
    ..We evidenced EDN pathway dysregulation based on EDN1, EDNRA, EDNRB and ARRB1 mRNA expression in LAM-derived primary cells...
  15. Magaki S, Hojat S, Wei B, So A, Yong W. An Introduction to the Performance of Immunohistochemistry. Methods Mol Biol. 2019;1897:289-298 pubmed publisher
    ..In: Dabbs DJ (ed) Diagnostic immunohistochemistry: theranostic and genomic applications, 3rd edn. Saunders, Philadelphia, 2010; Shi SR, Key ME, Kalra KL...
  16. Peterson K, Cobell W, Clayton F, Krishnamurthy C, Ying J, Pease L, et al. Extracellular Eosinophil Granule Protein Deposition in Ringed Esophagus with Sparse Eosinophils. Dig Dis Sci. 2015;60:2646-53 pubmed publisher
    ..were analyzed for eosinophil granule proteins, major basic protein 1 (eMBP1) and eosinophil-derived neurotoxin (EDN), by indirect immunofluorescence...
  17. Loktionov A, Chhaya V, Bandaletova T, Poullis A. Inflammatory bowel disease detection and monitoring by measuring biomarkers in non-invasively collected colorectal mucus. J Gastroenterol Hepatol. 2017;32:992-1002 pubmed publisher
    ..Calprotectin, eosinophil-derived neurotoxin (EDN), and protein S100A12 were measured in colorectal mucus self-collected following defecation by 58 patients with IBD ..
  18. Rooney P, Eagle M, Kearney J. Validation of cold chain shipping environment for transport of allografts as part of a human tissue bank returns policy. Cell Tissue Bank. 2015;16:553-8 pubmed publisher
    ..at -20 °C or lower" (Guidelines for the Blood Transfusion Services in the United Kingdom, 8th Edn. 2013)...
  19. Sircar M, Rosales I, Selig M, Xu D, Zsengellér Z, Stillman I, et al. Complement 7 Is Up-Regulated in Human Early Diabetic Kidney Disease. Am J Pathol. 2018;188:2147-2154 pubmed publisher
    ..Currently, there is no way to detect early diabetic nephropathy (EDN)...
  20. Park P, Lee T, Cho E. Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes. J Invest Dermatol. 2015;135:551-559 pubmed publisher
    ..In addition to melanogenesis-related genes, the expression of neurokinin 1 receptor, endothelin 1 (EDN1), and EDN receptor type B (EDNRB) also increased at both the messenger RNA and protein levels...
  21. Peterlin B, Rosso A, Nair S, Young W, Schwartzman R. Migraine may be a risk factor for the development of complex regional pain syndrome. Cephalalgia. 2010;30:214-23 pubmed publisher
    ..Headache diagnoses were made using International Classification of Headache Disorders, 2nd edn criteria. Migraine and pain characteristics were compared in those with migraine with those without...
  22. Chen L, Xiao J, Kuroda J, Ago T, Sadoshima J, Cohen R, et al. Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines. Biochim Biophys Acta. 2014;1842:2489-99 pubmed
    ..Mouse lines overexpressing human Nox4 wild type (EWT) or its dominant negative form P437H (EDN) specifically in the endothelium were used. Non-transgenic littermate mice (NTg) were used as controls...
  23. Takeo M, Lee W, Rabbani P, Sun Q, Hu H, Lim C, et al. EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling. Cell Rep. 2016;15:1291-302 pubmed publisher
    ..Here, we demonstrate that the Edn/EdnrB signaling pathway can interact with other signaling pathways to elicit distinct stem cell functions during ..
  24. Korzekwa A, Bodek G, Bukowska J, Blitek A, Skarzynski D. Characterization of bovine immortalized luteal endothelial cells: action of cytokines on production and content of arachidonic acid metabolites. Reprod Biol Endocrinol. 2011;9:27 pubmed publisher
    ..and interferon gamma (IFNgamma) on cell viability, leukotrienes (LTs) and PG synthases, and endothelin-1 (EDN-1) mRNA, protein expression and their secretion in bovine immortalized luteal endothelial (EnCL-1) cells...
  25. Yamada K, Barker T, Dyer K, Rice T, Percopo C, Garcia Crespo K, et al. Eosinophil-associated ribonuclease 11 is a macrophage chemoattractant. J Biol Chem. 2015;290:8863-75 pubmed publisher
    ..However, in contrast to RNase 2/EDN and mEar 2, which have been characterized as selective chemoattractants for CD11c(+) dendritic cells, mEar 11 ..
  26. Milne S, McDonald J, Kayrouz N. Determinants of developmental progress in pre-schoolers referred for neuro-developmental diagnosis. J Paediatr Child Health. 2016;: pubmed publisher
    ..They were assessed with the Bayley Scales of Infant and Toddler Development (3rd edn) before 3.5?years and the Griffiths Mental Development Scales before school entry...
  27. Winberg A, Nagaeva O, Nagaev I, Lundell C, Arencibia I, Mincheva Nilsson L, et al. Dynamics of cytokine mRNA expression and fecal biomarkers in school-children undergoing a double-blind placebo-controlled food challenge series. Cytokine. 2016;88:259-266 pubmed publisher
    ..Fecal calprotectin and eosinophil-derived neurotoxin (EDN) were also analyzed in children with suspected food allergy before and after the challenge series...
  28. Evgeni E, Lymberopoulos G, Touloupidis S, Asimakopoulos B. Sperm nuclear DNA fragmentation and its association with semen quality in Greek men. Andrologia. 2015;47:1166-74 pubmed publisher
    ..n = 485), according to the WHO 2010 (WHO Laboratory Manual for the Examination and Processing of Human Semen, 5th edn. World Health Organization), reference limits...
  29. Knezović N, Memić M, Mabić M, Huremović J, Mikulić I. Correlation between water hardness and cardiovascular diseases in Mostar city, Bosnia and Herzegovina. J Water Health. 2014;12:817-23 pubmed publisher
    ..testing of physical and chemical parameters of water were made using standardized methods: Standard Methods 19th edn, 1995 (APHA, AWWA & WEF, Washington, DC), and ISO 7888:1985, ISO 10523:1998...
  30. Oczkowicz G, Caban A, Budziński G, Suszka Switek A, Dolinska B, Czech E, et al. Endothelial Nitric Oxide Synthase and Endothelin-1 Expression in the Early Post-Porcine Kidney Autotransplantation Period. Transplant Proc. 2016;48:1833-5 pubmed publisher
    The aim of this study was the assessment of endothelial nitric oxide synthase (eNOS) and endothelin-1 (EDN-1) expression in porcine kidneys on the 14th and 30th days after the autotransplantation procedure...
  31. Fomin V, Richard P, Hoque M, Li C, Gu Z, Fissore O Leary M, et al. The C9ORF72 Gene, Implicated in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, Encodes a Protein That Functions in Control of Endothelin and Glutamate Signaling. Mol Cell Biol. 2018;38: pubmed publisher
    ..Unexpectedly, RNA analysis revealed changes in expression of many genes, including genes involved in endothelin (EDN) signaling and immune system pathways and multiple glutamate cycling genes (e.g...
  32. Kim C, Callaway Z, Park J, Nishimori H, Ogino T, Nagao M, et al. Montelukast Reduces Serum Levels of Eosinophil-Derived Neurotoxin in Preschool Asthma. Allergy Asthma Immunol Res. 2018;10:686-697 pubmed publisher
    ..We investigate a potentially useful relatively non-invasive biomarker, eosinophil-derived neurotoxin (EDN), to predict favorable responses to budesonide or montelukast, common treatment for children with asthma...
  33. Raboisson D, Caubet C, Tasca C, De Marchi L, Ferraton J, Gannac S, et al. Effect of acute and chronic excesses of dietary nitrogen on blood neutrophil functions in cattle. J Dairy Sci. 2014;97:7575-85 pubmed publisher
    Excess dietary nitrogen (EDN) is commonly expected in dairy herds, but no data are available regarding its consequences on cattle immunity. In this study neutrophil functions were assessed during EDN in steers...
  34. Azizi M, Seidi S, Rouhollahi A. A novel N,N'-bis(acetylacetone)ethylenediimine functionalized silica-core shell magnetic nanosorbent for manetic dispersive solid phase extraction of copper in cereal and water samples. Food Chem. 2018;249:30-37 pubmed publisher
    ..In this study, N,N'-bis (acetyl acetone) ethylenediimine (Fe3O4@SiO2-EDN) was synthesized and applied for dispersive solid phase extraction of copper in water and cereal samples followed ..
  35. Kessler R, Borges G, Sampson N, Miller M, Nock M. The association between smoking and subsequent suicide-related outcomes in the National Comorbidity Survey panel sample. Mol Psychiatry. 2009;14:1132-42 pubmed publisher
    ..and potential mediators (respondent history of Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, revised mental-substance disorders)...
  36. Lodin K, Lekander M, Syk J, Alving K, Andréasson A. Associations between self-rated health, sickness behaviour and inflammatory markers in primary care patients with allergic asthma: a longitudinal study. NPJ Prim Care Respir Med. 2017;27:67 pubmed publisher
    ..of immunoglobulin E (IgE), serum eosinophilic cationic protein (S-ECP), plasma eosinophil-derived neurotoxin (P-EDN) and fraction of exhaled nitric oxide (FENO)...
  37. Pham T, Damera G, Newbold P, Ranade K. Reductions in eosinophil biomarkers by benralizumab in patients with asthma. Respir Med. 2016;111:21-9 pubmed publisher
    ..Blood eosinophils, IL-5, eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), eotaxin/chemokine (C-C motif) 11 (CCL11), eotaxin-2/CCL24, tumor necrosis ..
  38. Carlson M, Venge P, Lampinen M. C3b-induced eosinophil degranulation involves PI3-kinases and is inhibited by protein kinase C activity. APMIS. 2011;119:119-26 pubmed publisher
    ..if selective release of eosinophil cationic protein (ECP), eosinophil protein X/eosinophil derived-neurotoxin (EPX/EDN) and eosinophil peroxidase (EPO) could be due to the involvement of different signal transduction pathways...
  39. Kosior Jarecka E, Wróbel Dudzińska D, Łukasik U, Aung T, Khor C, Kocki J, et al. Plasma endothelin-1 and single nucleotide polymorphisms of endothelin-1 and endothelin type A receptor genes as risk factors for normal tension glaucoma. Mol Vis. 2016;22:1256-1266 pubmed
    ..To analyze the frequency of polymorphic variants of the endothelin EDN gene (K198N) and the endothelin receptor type A gene EDN RA (C1222T, C70G, G231A), DNA was isolated from ..
  40. Makiya M, Herrick J, Khoury P, Prussin C, Nutman T, Klion A. Development of a suspension array assay in multiplex for the simultaneous measurement of serum levels of four eosinophil granule proteins. J Immunol Methods. 2014;411:11-22 pubmed publisher
    The concentrations of major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil derived neurotoxin (EDN) and eosinophil peroxidase (EPO) have been associated with eosinophilic disease severity...
  41. Moideen K, Kumar N, Nair D, Banurekha V, Bethunaickan R, Babu S. Heightened Systemic Levels of Neutrophil and Eosinophil Granular Proteins in Pulmonary Tuberculosis and Reversal following Treatment. Infect Immun. 2018;86: pubmed publisher
    ..myeloperoxidase (MPO), neutrophil elastase, proteinase 3, major basic protein (MBP), eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), and eosinophil peroxidase (EPX) in these individuals...
  42. Yamamoto Y, Kohka M, Kobayashi Y, Woclawek Potocka I, Okuda K. Endothelin as a local regulating factor in the bovine oviduct. Reprod Fertil Dev. 2016;28:673-81 pubmed publisher
    Endothelin (EDN) is a possible regulating factor of oviductal motility, which is important for the transport of gametes and embryo...
  43. Gadke D, McKinney C, Oliveros A. Autism Spectrum Disorder Symptoms and Comorbidity in Emerging Adults. Child Psychiatry Hum Dev. 2016;47:194-201 pubmed publisher
    ..use of psychological testing for treatment planning and outcomes assessment: volume 3: instruments for adults, 3rd edn. Lawrence Erlbaum Associates, Mahwah, pp 115-152, 2004)...
  44. Mortuaire G, Gengler I, Balden M, Capron M, Lefevre G. Impact of allergy on phenotypic and endotypic profiles of nasal polyposis. Eur Ann Otorhinolaryngol Head Neck Dis. 2018;135:159-162 pubmed publisher
    ..Inflammatory endotypes were determined on biomarker analysis (IgE, IgA, IL-5, IL-9, ECP, EDN) in blood and nasal secretions. Eosinophil counts were obtained in blood, nasal secretions and polyps...
  45. Kawaguchi R, Osuka K, Aoyama M, Miyachi S, Takayasu M. Expressions of Eotaxin-3, Interleukin-5 and Eosinophil-Derived Neurotoxin in Chronic Subdural Hematoma Fluids. J Neurotrauma. 2018;: pubmed publisher
    ..Ecalectin, eotaxin-3, interleukin-5 (IL-5) and eosinophil-derived neurotoxin (EDN) concentrations were measured using ELISA kits...
  46. Kamel G, Hoyos T, Rochard L, Dougherty M, Kong Y, Tse W, et al. Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis. Dev Biol. 2013;381:423-33 pubmed publisher
    ..In addition, expression of wnt9a and frzb was also absent in the edn-/- mutant...
  47. Martínez Barquero V, de Marco G, Martínez Hervas S, Rentero P, Galan Chilet I, Blesa S, et al. Polymorphisms in endothelin system genes, arsenic levels and obesity risk. PLoS ONE. 2015;10:e0118471 pubmed publisher
    Obesity has been linked to morbidity and mortality through increased risk for many chronic diseases. Endothelin (EDN) system has been related to endothelial function but it can be involved in lipid metabolism regulation: Receptor type A (..
  48. Grant B, Goldstein R, Chou S, Huang B, Stinson F, Dawson D, et al. Sociodemographic and psychopathologic predictors of first incidence of DSM-IV substance use, mood and anxiety disorders: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. Mol Psychiatry. 2009;14:1051-66 pubmed publisher
    ..and psychopathologic predictors of first incidence of Diagnostic and Statistical Manual of Mental Disorders, 4th edn (DSM-IV) substance, mood and anxiety disorders using the Wave 2 National Epidemiologic Survey on Alcohol and ..
  49. Kim S, Sohn I, Do I, Jang J, Kim S, Jung I, et al. Transcriptome analysis of CD133-positive stem cells and prognostic value of survivin in colorectal cancer. Cancer Genomics Proteomics. 2014;11:259-66 pubmed
    ..We found that in CD133(+) cells, 17 genes (RNASE2, PRB2, IL4, MGC27382, CLEC4C, SALL3, GIMAP1, ISG15, LOC728875, ZIK1, ICAM2, CCDC7, CDYL2, LRRC2, ZEB1, OSTF1 and ..
  50. Moulton E, Bradbury K, Barton M, Fein D. Factor Analysis of the Childhood Autism Rating Scale in a Sample of Two Year Olds with an Autism Spectrum Disorder. J Autism Dev Disord. 2016;: pubmed
    ..with DSM-IV-TR (American Psychiatric Association in Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Publishing, Washington, 2000) diagnoses of AD or PDD-NOS...
  51. Nakajima S. Complicated grief: recent developments in diagnostic criteria and treatment. Philos Trans R Soc Lond B Biol Sci. 2018;373: pubmed publisher
    ..DSM-5 (2013 Diagnostic and statistical manual of mental disorders, 5th edn) proposed 'persistent complex bereavement disorder' as a psychiatric disorder; it is similar to CG in that it is a ..
  52. Atkinson C, Martineau P, Khan R, Field J, Fisher D, Davies N, et al. Cleaving the Halqeh-ye-nur diamonds: a dynamic fracture analysis. Philos Trans A Math Phys Eng Sci. 2015;373: pubmed publisher
    ..1971 Contemp. Phys. 12, 1-31 (doi:10.1080/00107517108205103); Field JE. 1979 Properties of diamond, 1st edn, Academic Press; Wilks EM. 1958 Phil. Mag. 3, 1074-1080 (doi:10.1080/14786435808237036))...
  53. de Oliveira P, de Oliveira Lopes D, do Vale Coelho I, Pereira M. Cytotoxic Activities of Eosinophil Cationic Protein and Eosinophil-derived Neurotoxin: In Silico Analysis. Cancer Genomics Proteomics. 2015;12:397-402 pubmed
    Eosinophil cationic protein (ECP) and eosinophil derived-neurotoxin (EDN) are homologous ribonuclease (RNAse) A family proteins...
  54. Muehlhausen M, Janoske U, Oertel H. Implicit Partitioned Cardiovascular Fluid-Structure Interaction of the Heart Cycle Using Non-newtonian Fluid Properties and Orthotropic Material Behavior. Cardiovasc Eng Technol. 2015;6:8-18 pubmed publisher
    ..which incorporates blood rheology and the circulatory system (Oertel, Prandtl-Essentials of Fluid Mechanics, 3rd edn, Springer Science + Business Media, 2010; Oertel et al...
  55. Kumari B, Prabhakar A, Sahu A, Chatterjee T, Tyagi T, Gupta N, et al. Endothelin-1 Gene Polymorphism and Its Level Predict the Risk of Venous Thromboembolism in Male Indian Population. Clin Appl Thromb Hemost. 2017;23:429-437 pubmed publisher
    ..We studied 133 patients with VTE and 164 healthy controls. Endothelin (EDN) G8002A, EDN T1370G, EDN 3A/4A, eNOSG894T, angiotensin-converting enzyme I/D, vascular endothelial growth factor ..
  56. Uchimizu H, Matsuwaki Y, Kato M, Otori N, Kojima H. Eosinophil-derived neurotoxin, elastase, and cytokine profile in effusion from eosinophilic otitis media. Allergol Int. 2015;64 Suppl:S18-23 pubmed publisher
    ..Eosinophil-derived neurotoxin (EDN) and elastase were measured by ELISA...
  57. Hwang Y, Lee H, Lee Y, Cho H. Cell wall-associated ROOT HAIR SPECIFIC 10, a proline-rich receptor-like kinase, is a negative modulator of Arabidopsis root hair growth. J Exp Bot. 2016;67:2007-22 pubmed publisher
    ..A yeast two-hybrid screening identified an RNase (RNS2) as a putative downstream target of RHS10...
  58. Binz N, Rakoczy E, Ali Rahman I, Vagaja N, Lai C. Biomarkers for Diabetic Retinopathy - Could Endothelin 2 Be Part of the Answer?. PLoS ONE. 2016;11:e0160442 pubmed publisher
    ..Endothelin (Edn) dysregulation has been implicated in a number of pathophysiologies, including diabetes and diabetes-related ..
  59. Kim M, Yoo J, Kim J, Park J, Han E, Jang W, et al. Association of FLG single nucleotide variations with clinical phenotypes of atopic dermatitis. PLoS ONE. 2017;12:e0190077 pubmed publisher
    ..Serologic parameters such as serum eosinophil cationic protein (ECP) and eosinophil derived neurotoxin (EDN) were measured. A total of seventy-three SNVs and 4 LOF mutations were successfully genotyped...
  60. Geng R, Liu H, Wang W. Differential Expression of Six Rnase2 and Three Rnase3 Paralogs Identified in Blunt Snout Bream in Response to Aeromonas hydrophila Infection. Genes (Basel). 2018;9: pubmed publisher
    ..In this study, we identified multiple copies of Rnase2 (six) and Rnase3 (three) in the M. amblycephala genome...
  61. Abdel Rahman M, Hashad I, Abou Aisha K, Abdel Maksoud S, Gad M. Assessment of the link between endothelin K198n Snp, endothelin concentration and acute myocardial infarction in Egyptians. Clin Exp Pharmacol Physiol. 2017;44:132-134 pubmed publisher
    The aim of the current study was to assess the link between EDN K198N SNP, ET-1 serum concentration and acute myocardial infarction (AMI) in Egyptians...
  62. Ye B, Skates S, Mok S, Horick N, Rosenberg H, Vitonis A, et al. Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine. Clin Cancer Res. 2006;12:432-41 pubmed
    ..than in benign conditions and controls was identified and subsequently defined as eosinophil-derived neurotoxin (EDN). A glycosylated form of EDN was specifically elevated in ovarian cancer patients...
  63. Gon Y, Ito R, Hattori T, Hiranuma H, Kumasawa F, Kozu Y, et al. Serum eosinophil-derived neurotoxin: correlation with persistent airflow limitation in adults with house-dust mite allergic asthma. Allergy Asthma Proc. 2015;36:e113-20 pubmed publisher
    The serum level of eosinophil-derived neurotoxin (EDN), a protein present in eosinophil granules, correlates with the severity of childhood asthma...
  64. Chatzileontiadou D, Parmenopoulou V, Manta S, Kantsadi A, Kylindri P, Griniezaki M, et al. Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin. Bioorg Chem. 2015;63:152-65 pubmed publisher
    b>Eosinophil derived neurotoxin (EDN) is an eosinophil secretion protein and a member of the Ribonuclease A (RNase A) superfamily involved in the immune response system and inflammatory disorders...
  65. Abbas A, Moseley D, Kassam Z, Kim S, Cho C. Volumetric-modulated arc therapy for the treatment of a large planning target volume in thoracic esophageal cancer. J Appl Clin Med Phys. 2013;14:4269 pubmed publisher
    ..Thirteen patients, stage T2-T3 N0-N1 (TNM AJCC 7th edn.), PTV volume median 395 cc (range 281-601 cc), median age 69 years (range 53 to 85), were treated from July 2010 ..
  66. Noguchi T, Nakagome K, Kobayashi T, Ueda Y, Soma T, Nakamoto H, et al. Effect of beta2-adrenergic agonists on eosinophil adhesion, superoxide anion generation, and degranulation. Allergol Int. 2015;64 Suppl:S46-53 pubmed publisher
    ..Eosinophil-derived neurotoxin (EDN) release was evaluated by ELISA as a marker of degranulation...
  67. Kim C, Callaway Z, Park J, Kwon E. Utility of serum eosinophil-derived neurotoxin (EDN) measurement by ELISA in young children with asthma. Allergol Int. 2017;66:70-74 pubmed publisher
    This study was done to compare the efficacy of a recently developed eosinophil-derived neurotoxin (EDN) ELISA kit ("BioTracer™ K® EDN ELISA Kit") to a commercially available EDN ELISA kit ("MBL EDN ELISA Kit") and ..
  68. Sultana B, Yaqoob S, Zafar Z, Bhatti H. Escalation of liver malfunctioning: A step toward Herbal Awareness. J Ethnopharmacol. 2018;216:104-119 pubmed publisher
    ..K, Churchill Livingstone, London, UK; Herbal Drugs and Phytopharmaceuticals, Wichtl M Medpharm Press, Stuttgart 3rd edn; Pharmacology and Applications of Chinese Materia Medica Vols 1 and 2, Chang H-M and But P P-H World Scientific, ..
  69. Agache I, Strasser D, Klenk A, Agache C, Farine H, Ciobanu C, et al. Serum IL-5 and IL-13 consistently serve as the best predictors for the blood eosinophilia phenotype in adult asthmatics. Allergy. 2016;71:1192-202 pubmed publisher
    ..A robust relationship was observed between blood eosinophilia and IL-5, IL-13, and eosinophil-derived neurotoxin (EDN), which stayed consistent after 6 weeks...
  70. Min S, Nylund C, Baker T, Ally M, Reinhardt B, Chen Y, et al. Longitudinal Evaluation of Noninvasive Biomarkers for Eosinophilic Esophagitis. J Clin Gastroenterol. 2017;51:127-135 pubmed publisher
    ..obtained, as well as, serum analysis of absolute eosinophil count (AEC), eotaxin-3, eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP) and interleukin-5...
  71. Gagne D, Narayanan C, Bafna K, Charest L, Agarwal P, Doucet N. Sequence-specific backbone resonance assignments and microsecond timescale molecular dynamics simulation of human eosinophil-derived neurotoxin. Biomol NMR Assign. 2017;11:143-149 pubmed publisher
    ..The functional homologs eosinophil-derived neurotoxin (EDN, or RNase 2) and eosinophil cationic protein (ECP, or RNase 3) are known to be expressed and secreted by eosinophils in ..
  72. Giusti D, Gatouillat G, Le Jan S, Plee J, Bernard P, Antonicelli F, et al. Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome. Sci Rep. 2017;7:4833 pubmed publisher
    ..However, the release of Major Basic Protein (MBP), Eosinophil Derived Neurotoxin (EDN), and Eosinophil Cationic Protein (ECP) upon eosinophil activation has still not been evaluated ..
  73. Comperat E, Varinot J. Immunochemical and molecular assessment of urothelial neoplasms and aspects of the 2016 World Health Organization classification. Histopathology. 2016;69:717-726 pubmed publisher
    The new World Health Organization classification of tumours of the urinary system and male genital organs (4th edn) has several changes from previous versions, and was published in January 2016...
  74. Attery A, Batra J. Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic, antibacterial and antiparasitic activities. Int J Biol Macromol. 2017;94:445-450 pubmed publisher
    ..contain two ribonucleases belonging to the RNase A family, eosinophil cationic protein (ECP) and eosinophil derived neurotoxin (EDN)...
  75. Rosenberg H. Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense. Int J Mol Sci. 2015;16:15442-55 pubmed publisher
    The eosinophil-derived neurotoxin (EDN/RNase2) and its divergent orthologs, the mouse eosinophil-associated RNases (mEars), are prominent secretory proteins of eosinophilic leukocytes and are all members of the larger family of RNase A-..
  76. Russignan A, Spina C, Tamassia N, Cassaro A, Rigo A, Bagnato A, et al. Endothelin-1 receptor blockade as new possible therapeutic approach in multiple myeloma. Br J Haematol. 2017;178:781-793 pubmed publisher
    ..The endothelin-1 (EDN1) axis, consisting of EDN1 acting through EDN-receptor A (EDNRA) and B (EDNRB), was previously shown to be overexpressed in several tumours, including MM...
  77. Engemann H, Hendriks H, Hickmann M, Soroli E, Vincent C. How language impacts memory of motion events in English and French. Cogn Process. 2015;16 Suppl 1:209-13 pubmed publisher
    ..MANNER and PATH of motion (Talmy in Toward a cognitive semantics: typology and process in concept structuring, 2nd edn, vol 2. MIT Press, Cambridge, 2000)...
  78. Jeon Y, Min T, Yang H, Pyun B. A Double-Blind, Randomized, Crossover Study to Compare the Effectiveness of Montelukast on Atopic Dermatitis in Korean Children. Allergy Asthma Immunol Res. 2016;8:305-11 pubmed publisher
    ..The SCORing atopic dermatitis (SCORAD) index, urinary leukotriene E? (LTE?), and eosinophil-derived neurotoxin (EDN) were assessed at every visit. Forty-three patients (21 males) completed the study...
  79. Hu L, Wang X, Jiang X, Xu L, Pan H. In vivo and in vitro study of osteogenic potency of endothelin-1 on bone marrow-derived mesenchymal stem cells. Exp Cell Res. 2017;357:25-32 pubmed publisher
    ..Endothelin-1?EDN-1?is produced by vascular endothelial cells which plays an important role during bone development...
  80. Chawes B, Bønnelykke K, Bisgaard H. Elevated eosinophil protein X in urine from healthy neonates precedes development of atopy in the first 6 years of life. Am J Respir Crit Care Med. 2011;184:656-61 pubmed publisher
    ..These findings suggest activation of eosinophil granulocytes early in life before development of atopy-related symptoms. ..
  81. Singla D, Kumbakumba E, Aboud F. Effects of a parenting intervention to address maternal psychological wellbeing and child development and growth in rural Uganda: a community-based, cluster randomised trial. Lancet Glob Health. 2015;3:e458-e469 pubmed publisher
    ..were cognitive and receptive language development, as measured with the Bayley Scales of Infant Development, 3rd edn. Secondary outcomes included self-reported maternal depressive symptoms, using the Center for Epidemiologic Studies ..
  82. Wei H, Pareek T, Liu Q, Letterio J. A unique tolerizing dendritic cell phenotype induced by the synthetic triterpenoid CDDO-DFPA (RTA-408) is protective against EAE. Sci Rep. 2017;7:9886 pubmed publisher
    ..CDDO-DFPA (RTA-408) results in the induction of HO-1, TGF-β, and IL-10, as well as the repression of NF-κB, EDN-1 and pro-inflammatory cytokines IL-6, IL-12, and TNFα...
  83. Plager D, Davis M, Andrews A, Coenen M, George T, Gleich G, et al. Eosinophil ribonucleases and their cutaneous lesion-forming activity. J Immunol. 2009;183:4013-20 pubmed publisher
    ..We injected eosinophil cationic protein (ECP or RNase 3), eosinophil-derived neurotoxin (EDN or RNase 2), eosinophil peroxidase (EPO), and major basic protein-1 (MBP1) intradermally into guinea pig and rabbit skin...
  84. Valenza F, Coppola S, Froio S, Ruggeri G, Fumagalli J, Villa A, et al. A standardized model of brain death, donor treatment, and lung transplantation for studies on organ preservation and reconditioning. Intensive Care Med Exp. 2014;2:12 pubmed publisher
    ..chemokine CXC motif ligand-10 (CXCL-10), interleukin-8 (IL-8)), and endothelial activation markers (endothelin-1 (EDN-1), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), selectin-E (SELE)) was ..
  85. Pham D, Ban G, Kim S, Shin Y, Ye Y, Chwae Y, et al. Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma. Clin Exp Allergy. 2017;47:57-70 pubmed publisher
    ..by investigating the activation and release of eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN)...
  86. Tagashira H, Miyamoto A, Kitamura S, Tsubata M, Yamaguchi K, Takagaki K, et al. UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Maritime Pine Bark Extract through a Direct Inactivation of MSK1. PLoS ONE. 2015;10:e0128678 pubmed publisher
    ..between keratinocytes and melanocytes are crucial for regulating epidermal pigmentation, the endothelin (EDN)-endothelin B-receptor (EDNRB) interaction is one of the key linkages...
  87. Floyd B, Mugume Y, Morriss S, MacIntosh G, Bassham D. Localization of RNS2 ribonuclease to the vacuole is required for its role in cellular homeostasis. Planta. 2017;245:779-792 pubmed publisher
    Localization of the RNase RNS2 to the vacuole via a C-terminal targeting signal is essential for its function in rRNA degradation and homeostasis...
  88. Roca M, Rodriguez Varela A, Donat E, Cano F, Hervás D, Armisen A, et al. Fecal Calprotectin and Eosinophil-derived Neurotoxin in Healthy Children Between 0 and 12 Years. J Pediatr Gastroenterol Nutr. 2017;65:394-398 pubmed publisher
    ..The proposed nomograms and reference values for fCP and fEDN are aimed at facilitating the applicability of biomarkers for both neutrophil- and eosinophil-mediated intestinal inflammation in children in clinical practice. ..
  89. Kao C, Cheng S, Wu M, Chien S, Lu H, Hsu Y, et al. Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure. BMC Nephrol. 2017;18:291 pubmed publisher
    ..The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis...
  90. Hamann K, Barker R, Loegering D, Pease L, Gleich G. Sequence of human eosinophil-derived neurotoxin cDNA: identity of deduced amino acid sequence with human nonsecretory ribonucleases. Gene. 1989;83:161-7 pubmed
    Several clones of human eosinophil-derived neurotoxin (EDN) cDNA have been isolated from a lambda gt10 cDNA library prepared from mRNA derived from noninduced HL-60 cells...
  91. Wagner L, Christensen C, Dunn D, Spangrude G, Georgelas A, Kelley L, et al. EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression. Blood. 2007;109:5191-8 pubmed
    ..RNA silencing of EGO results in decreased major basic protein (MBP) and eosinophil derived neurotoxin (EDN) mRNA expression in developing CD34(+) hematopoietic progenitors in vitro and in a CD34(+) cell ..
  92. Mastrianni D, Eddy R, Rosenberg H, Corrette S, Shows T, Tenen D, et al. Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to. Genomics. 1992;13:240-2 pubmed