RMI2

Summary

Gene Symbol: RMI2
Description: RecQ mediated genome instability 2
Alias: BLAP18, C16orf75, recQ-mediated genome instability protein 2, BLM-associated protein of 18 kDa, RMI2, RecQ mediated genome instability 2, homolog
Species: human
Products:     RMI2

Top Publications

  1. Xu D, Guo R, Sobeck A, Bachrati C, Yang J, Enomoto T, et al. RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes Dev. 2008;22:2843-55 pubmed publisher
    ..Here we report a novel component of the BLM complex, RMI2, which interacts with RMI1 through two oligonucleotide-binding (OB)-fold domains similar to those in RPA...
  2. Singh T, Ali A, Busygina V, Raynard S, Fan Q, Du C, et al. BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. Genes Dev. 2008;22:2856-68 pubmed publisher
    ..Here we report the isolation and characterization of a novel member of the BTB complex termed BLAP18/RMI2...
  3. Hoadley K, Xu D, Xue Y, Satyshur K, Wang W, Keck J. Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome. Structure. 2010;18:1149-58 pubmed publisher
    ..which also includes topoisomerase III? and the RMI (RecQ-mediated genome instability) subcomplex (RMI1 and RMI2). We describe the crystal structure of the RMI core complex, comprising RMI2 and the C-terminal OB domain of RMI1...
  4. Deans A, West S. FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia. Mol Cell. 2009;36:943-53 pubmed publisher
    ..Moreover, a common phenotype of BS and FA cells-an elevated frequency of sister chromatid exchanges-was due to a loss of interaction of the two complexes through FANCM. ..
  5. Hudson D, Amor D, Boys A, Butler K, Williams L, Zhang T, et al. Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome. PLoS Genet. 2016;12:e1006483 pubmed publisher
    ..Here we report the identification of a second gene, RMI2, that is deleted in affected siblings with Bloom-like features...
  6. Cooper J, Smyth D, Smiles A, Plagnol V, Walker N, Allen J, et al. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet. 2008;40:1399-401 pubmed publisher
    ..7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8)). ..
  7. Fransen K, Visschedijk M, van Sommeren S, Fu J, Franke L, Festen E, et al. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. Hum Mol Genet. 2010;19:3482-8 pubmed publisher
    ..UBE2L3 is also associated with other immune-mediated diseases. These results show that eQTL-based pre-selection for follow-up is a useful approach for identifying risk loci from a moderately sized GWAS. ..
  8. Ali A, Pradhan A, Singh T, Du C, Li J, Wahengbam K, et al. FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway. Blood. 2012;119:3285-94 pubmed publisher
    ..These findings reveal critical roles for FAAP20 in the FA-BRCA pathway of DNA damage repair and genome maintenance. ..
  9. Daley J, Chiba T, Xue X, Niu H, Sung P. Multifaceted role of the Topo IIIα-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection. Nucleic Acids Res. 2014;42:11083-91 pubmed publisher
    ..BLM exists in a complex with Topo IIIα, RMI1 and RMI2. Herein, we address the role of Topo IIIα and RMI1-RMI2 in resection using a reconstituted system with purified ..

More Information

Publications13

  1. Singh T, Saro D, Ali A, Zheng X, Du C, Killen M, et al. MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Mol Cell. 2010;37:879-86 pubmed publisher
    ..These findings reveal critical roles of the MHF1-MHF2 dimer in DNA damage repair and genome maintenance through FANCM. ..
  2. Wang F, Yang Y, Singh T, Busygina V, Guo R, Wan K, et al. Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex. Structure. 2010;18:1159-70 pubmed publisher
    ..BLM associates with topoisomerase (Topo) III?, RMI1, and RMI2 to form the BLM complex that is essential for genome stability...
  3. Hoadley K, Xue Y, Ling C, Takata M, Wang W, Keck J. Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome. Proc Natl Acad Sci U S A. 2012;109:4437-42 pubmed publisher
    The RMI subcomplex (RMI1/RMI2) functions with the BLM helicase and topoisomerase III? in a complex called the "dissolvasome," which separates double-Holliday junction DNA structures that can arise during DNA repair...
  4. Pradhan A, Singh T, Ali A, Wahengbam K, Meetei A. Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III ?-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation. J Biol Chem. 2013;288:33500-8 pubmed publisher
    ..BLM is a RecQ helicase component of the BLM-Topo III ?-RMI1-RMI2 (BTR) complex, which maintains chromosome stability at the spindle assembly checkpoint (SAC)...