Genomes and Genes
Gene Symbol: RMI2
Description: RecQ mediated genome instability 2
Alias: BLAP18, C16orf75, recQ-mediated genome instability protein 2, BLM-associated protein of 18 kDa, RMI2, RecQ mediated genome instability 2, homolog
- Singh T, Saro D, Ali A, Zheng X, Du C, Killen M, et al. MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Mol Cell. 2010;37:879-86 pubmed publisher..These findings reveal critical roles of the MHF1-MHF2 dimer in DNA damage repair and genome maintenance through FANCM. ..
- Wang F, Yang Y, Singh T, Busygina V, Guo R, Wan K, et al. Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex. Structure. 2010;18:1159-70 pubmed publisher..BLM associates with topoisomerase (Topo) III?, RMI1, and RMI2 to form the BLM complex that is essential for genome stability...
- Hoadley K, Xue Y, Ling C, Takata M, Wang W, Keck J. Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome. Proc Natl Acad Sci U S A. 2012;109:4437-42 pubmed publisherThe RMI subcomplex (RMI1/RMI2) functions with the BLM helicase and topoisomerase III? in a complex called the "dissolvasome," which separates double-Holliday junction DNA structures that can arise during DNA repair...
- Pradhan A, Singh T, Ali A, Wahengbam K, Meetei A. Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III ?-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation. J Biol Chem. 2013;288:33500-8 pubmed publisher..BLM is a RecQ helicase component of the BLM-Topo III ?-RMI1-RMI2 (BTR) complex, which maintains chromosome stability at the spindle assembly checkpoint (SAC)...